Publication Information

{'id': 'https://openalex.org/W1969771853', 'doi': 'https://doi.org/10.1074/jbc.m313061200', 'title': 'Squalestatin Cures Prion-infected Neurons and Protects Against Prion Neurotoxicity', 'display_name': 'Squalestatin Cures Prion-infected Neurons and Protects Against Prion Neurotoxicity', 'publication_year': 2004, 'publication_date': '2004-04-01', 'ids': {'openalex': 'https://openalex.org/W1969771853', 'doi': 'https://doi.org/10.1074/jbc.m313061200', 'mag': '1969771853', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/14754889'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m313061200', 'pdf_url': 'http://www.jbc.org/article/S0021925819638949/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925819638949/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5060254479', 'display_name': 'Clive Bate', 'orcid': 'https://orcid.org/0000-0002-1378-0005'}, 'institutions': [{'id': 'https://openalex.org/I7882870', 'display_name': 'University of Glasgow', 'ror': 'https://ror.org/00vtgdb53', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I7882870']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Clive Bate', 'raw_affiliation_strings': ['Institute of Comparative Medicine, Department of Veterinary Pathology, University of Glasgow Veterinary School, Bearsden Road, Glasgow G61 1QH, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Institute of Comparative Medicine, Department of Veterinary Pathology, University of Glasgow Veterinary School, Bearsden Road, Glasgow G61 1QH, United Kingdom', 'institution_ids': ['https://openalex.org/I7882870']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020722865', 'display_name': 'Mario Salmona', 'orcid': 'https://orcid.org/0000-0002-9098-9873'}, 'institutions': [{'id': 'https://openalex.org/I19630809', 'display_name': 'Mario Negri Institute for Pharmacological Research', 'ror': 'https://ror.org/05aspc753', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I19630809', 'https://openalex.org/I4210110338', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Mario Salmona', 'raw_affiliation_strings': ['Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milano, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milano, Italy', 'institution_ids': ['https://openalex.org/I19630809']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065883261', 'display_name': 'Luisa Diomede', 'orcid': 'https://orcid.org/0000-0002-2258-0531'}, 'institutions': [{'id': 'https://openalex.org/I19630809', 'display_name': 'Mario Negri Institute for Pharmacological Research', 'ror': 'https://ror.org/05aspc753', 'country_code': 'IT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I19630809', 'https://openalex.org/I4210110338', 'https://openalex.org/I4210153126']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Luisa Diomede', 'raw_affiliation_strings': ['Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milano, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157 Milano, Italy', 'institution_ids': ['https://openalex.org/I19630809']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5045174960', 'display_name': 'Steven Williams', 'orcid': 'https://orcid.org/0000-0003-4299-1941'}, 'institutions': [{'id': 'https://openalex.org/I133836048', 'display_name': 'Royal Veterinary College', 'ror': 'https://ror.org/01wka8n18', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I133836048']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Alun Williams', 'raw_affiliation_strings': ['Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Herts AL9 7TA, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology and Infectious Diseases, Royal Veterinary College, Hawkshead Lane, North Mymms, Herts AL9 7TA, United Kingdom', 'institution_ids': ['https://openalex.org/I133836048']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 4.277, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 131, 'citation_normalized_percentile': {'value': 0.932763, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '279', 'issue': '15', 'first_page': '14983', 'last_page': '14990'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11335', 'display_name': 'Prion Diseases and Protein Misfolding', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11335', 'display_name': 'Prion Diseases and Protein Misfolding', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13481', 'display_name': 'Neurological diseases and metabolism', 'score': 0.9963, 'subfield': {'id': 'https://openalex.org/subfields/2808', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12610', 'display_name': 'RNA regulation and disease', 'score': 0.9842, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/neurotoxicity', 'display_name': 'Neurotoxicity', 'score': 0.5459151}, {'id': 'https://openalex.org/keywords/lipid-raft', 'display_name': 'Lipid raft', 'score': 0.52491295}, {'id': 'https://openalex.org/keywords/squalene', 'display_name': 'Squalene', 'score': 0.4358544}], 'concepts': [{'id': 'https://openalex.org/C2776925932', 'wikidata': 'https://www.wikidata.org/wiki/Q1755122', 'display_name': 'Neurodegeneration', 'level': 3, 'score': 0.7700765}, {'id': 'https://openalex.org/C53345823', 'wikidata': 'https://www.wikidata.org/wiki/Q5531554', 'display_name': 'Gene isoform', 'level': 3, 'score': 0.676937}, {'id': 'https://openalex.org/C2776735649', 'wikidata': 'https://www.wikidata.org/wiki/Q170102', 'display_name': 'Scrapie', 'level': 4, 'score': 0.5750612}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5659677}, {'id': 'https://openalex.org/C2779830541', 'wikidata': 'https://www.wikidata.org/wiki/Q1622829', 'display_name': 'Microglia', 'level': 3, 'score': 0.55440164}, {'id': 'https://openalex.org/C2779491297', 'wikidata': 'https://www.wikidata.org/wiki/Q3338704', 'display_name': 'Neurotoxicity', 'level': 3, 'score': 0.5459151}, {'id': 'https://openalex.org/C79266657', 'wikidata': 'https://www.wikidata.org/wiki/Q424178', 'display_name': 'Lipid raft', 'level': 3, 'score': 0.52491295}, {'id': 'https://openalex.org/C3019804061', 'wikidata': 'https://www.wikidata.org/wiki/Q14881255', 'display_name': 'Prion protein', 'level': 3, 'score': 0.48497963}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.45947522}, {'id': 'https://openalex.org/C2778163477', 'wikidata': 'https://www.wikidata.org/wiki/Q43656', 'display_name': 'Cholesterol', 'level': 2, 'score': 0.45484057}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.4381233}, {'id': 'https://openalex.org/C2776703722', 'wikidata': 'https://www.wikidata.org/wiki/Q407560', 'display_name': 'Squalene', 'level': 2, 'score': 0.4358544}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3136425}, {'id': 'https://openalex.org/C29730261', 'wikidata': 'https://www.wikidata.org/wiki/Q274160', 'display_name': 'Toxicity', 'level': 2, 'score': 0.15784231}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.14600646}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.1229558}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.11226112}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.07911876}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.07597214}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D019086', 'descriptor_name': 'Bridged Bicyclo Compounds, Heterocyclic', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018621', 'descriptor_name': 'PrPC Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D018620', 'descriptor_name': 'PrPSc Proteins', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D011328', 'descriptor_name': 'Prions', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014233', 'descriptor_name': 'Tricarboxylic Acids', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000831', 'descriptor_name': 'Animals, Newborn', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019086', 'descriptor_name': 'Bridged Bicyclo Compounds, Heterocyclic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002784', 'descriptor_name': 'Cholesterol', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002784', 'descriptor_name': 'Cholesterol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003902', 'descriptor_name': 'Detergents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D003902', 'descriptor_name': 'Detergents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015232', 'descriptor_name': 'Dinoprostone', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015232', 'descriptor_name': 'Dinoprostone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004797', 'descriptor_name': 'Enzyme-Linked Immunosorbent Assay', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015850', 'descriptor_name': 'Interleukin-6', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015850', 'descriptor_name': 'Interleukin-6', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D021962', 'descriptor_name': 'Membrane Microdomains', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D021962', 'descriptor_name': 'Membrane Microdomains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008798', 'descriptor_name': 'Mevalonic Acid', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D008798', 'descriptor_name': 'Mevalonic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017628', 'descriptor_name': 'Microglia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017628', 'descriptor_name': 'Microglia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009447', 'descriptor_name': 'Neuroblastoma', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009447', 'descriptor_name': 'Neuroblastoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017830', 'descriptor_name': 'Octoxynol', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D017830', 'descriptor_name': 'Octoxynol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018621', 'descriptor_name': 'PrPC Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018620', 'descriptor_name': 'PrPSc Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011328', 'descriptor_name': 'Prions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014233', 'descriptor_name': 'Tricarboxylic Acids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m313061200', 'pdf_url': 'http://www.jbc.org/article/S0021925819638949/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://researchonline.rvc.ac.uk/id/eprint/1037/', 'pdf_url': 'https://rvc-repository.worktribe.com/preview/1722634/The%20Journal%20of%20Pathology%20-%202024%20-%20Jahangir%20-%20Image___based%20multiplex%20immune%20profiling%20of%20cancer%20tissues%20%20translational.pdf', 'source': {'id': 'https://openalex.org/S4306402069', 'display_name': 'RVC Research Online (Royal Veterinary College)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I133836048', 'host_organization_name': 'Royal Veterinary College', 'host_organization_lineage': ['https://openalex.org/I133836048'], 'host_organization_lineage_names': ['Royal Veterinary College'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.openaccessrepository.it/record/95159', 'pdf_url': 'https://www.openaccessrepository.it/record/95159/files/fulltext.pdf', 'source': {'id': 'https://openalex.org/S4306402478', 'display_name': 'INFM-OAR (INFN Catania)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210116497', 'host_organization_name': 'Istituto Nazionale di Fisica Nucleare, Sezione di Catania', 'host_organization_lineage': ['https://openalex.org/I4210116497'], 'host_organization_lineage_names': ['Istituto Nazionale di Fisica Nucleare, Sezione di Catania'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/14754889', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m313061200', 'pdf_url': 'http://www.jbc.org/article/S0021925819638949/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 54, 'referenced_works': ['https://openalex.org/W1533604120', 'https://openalex.org/W1561650220', 'https://openalex.org/W1586450452', 'https://openalex.org/W1611096381', 'https://openalex.org/W1646206347', 'https://openalex.org/W1819048918', 'https://openalex.org/W1965583284', 'https://openalex.org/W1972047666', 'https://openalex.org/W1972409470', 'https://openalex.org/W1975096886', 'https://openalex.org/W1975109489', 'https://openalex.org/W1979643175', 'https://openalex.org/W1984814063', 'https://openalex.org/W1985246693', 'https://openalex.org/W1989693627', 'https://openalex.org/W1990394752', 'https://openalex.org/W1992380356', 'https://openalex.org/W1992804077', 'https://openalex.org/W1994142447', 'https://openalex.org/W1998038512', 'https://openalex.org/W2001312162', 'https://openalex.org/W2002346340', 'https://openalex.org/W2006259119', 'https://openalex.org/W2010238780', 'https://openalex.org/W2013679718', 'https://openalex.org/W2013902668', 'https://openalex.org/W2016878695', 'https://openalex.org/W2022295948', 'https://openalex.org/W2022392367', 'https://openalex.org/W2026534774', 'https://openalex.org/W2027785700', 'https://openalex.org/W2028156020', 'https://openalex.org/W2042978244', 'https://openalex.org/W2043943109', 'https://openalex.org/W2052201373', 'https://openalex.org/W2064502163', 'https://openalex.org/W2065193233', 'https://openalex.org/W2068418997', 'https://openalex.org/W2071212117', 'https://openalex.org/W2081852339', 'https://openalex.org/W2089731024', 'https://openalex.org/W2090081205', 'https://openalex.org/W2102522362', 'https://openalex.org/W2103823881', 'https://openalex.org/W2110885272', 'https://openalex.org/W2111426823', 'https://openalex.org/W2121936687', 'https://openalex.org/W2124342403', 'https://openalex.org/W2125149319', 'https://openalex.org/W2144822024', 'https://openalex.org/W2147987476', 'https://openalex.org/W2160176970', 'https://openalex.org/W2161821089', 'https://openalex.org/W2168526937'], 'related_works': ['https://openalex.org/W4394269915', 'https://openalex.org/W4299131034', 'https://openalex.org/W3038794698', 'https://openalex.org/W2300054455', 'https://openalex.org/W22092127', 'https://openalex.org/W2108835608', 'https://openalex.org/W2022473302', 'https://openalex.org/W1992537259', 'https://openalex.org/W1860663863', 'https://openalex.org/W1486964495'], 'abstract_inverted_index': {'A': [0, 190, 906, 3137, 3199], 'key': [1, 191], 'feature': [2, 192, 1254], 'of': [3, 9, 23, 44, 50, 74, 82, 93, 122, 137, 145, 182, 193, 199, 213, 234, 240, 264, 272, 283, 312, 327, 335, 372, 410, 412, 416, 448, 535, 590, 602, 692, 700, 796, 815, 853, 858, 904, 1061, 1084, 1087, 1093, 1168, 1173, 1184, 1224, 1237, 1245, 1255, 1292, 1339, 1382, 1390, 1515, 1525, 1561, 1656, 1683, 1732, 1748, 1800, 1806, 1831, 1966, 1994, 2035, 2079, 2087, 2099, 2213, 2226, 2302, 2339, 2348, 2353, 2380, 2591, 2605, 2641, 2653, 2745, 2790, 2807, 2820, 2879, 2890, 2895, 2974, 3004, 3013, 3043, 3084, 3117, 3147, 3270, 3314, 3351, 3418, 3530, 3539, 3577, 3587, 3595, 3646, 3653, 3705, 3780, 3792, 3800, 3866, 3870, 3877, 3921, 3937, 3981, 4021, 4044, 4080, 4100, 4129, 4136, 4149, 4158, 4165, 4181, 4184, 4189, 4220, 4249, 4258, 4267, 4276, 4281, 4290, 4296, 4305, 4311, 4320, 4325, 4334, 4347, 4371, 4389, 4418, 4436, 4454, 4459], 'prion': [4, 13, 132, 163, 194, 203, 322, 353, 603, 1256, 1304, 1738, 1750, 2660, 2901, 3087, 3150, 3259, 3278], 'diseases': [5, 195, 404, 604, 1257, 1739], 'is': [6, 25, 157, 196, 215, 347, 457, 576, 597, 703, 819, 900, 1251, 1676, 3563, 3590, 3656, 4228], 'the': [7, 10, 21, 32, 35, 41, 48, 118, 143, 180, 197, 200, 211, 222, 225, 231, 238, 308, 333, 370, 408, 422, 449, 515, 587, 600, 687, 698, 851, 856, 909, 1059, 1085, 1161, 1166, 1182, 1222, 1233, 1243, 1249, 1274, 1336, 1365, 1374, 1388, 1423, 1502, 1513, 1559, 1564, 1654, 1798, 1811, 1925, 1964, 1969, 1990, 2053, 2085, 2097, 2100, 2120, 2172, 2307, 2318, 2346, 2351, 2376, 2589, 2603, 2651, 2673, 2698, 2743, 2788, 2893, 2923, 2972, 3000, 3033, 3057, 3085, 3118, 3148, 3205, 3268, 3331, 3558, 3571, 3703, 3774, 3814, 3864, 3875, 3919, 3992, 4077, 4097, 4107, 4147, 4156, 4163, 4178, 4229, 4345, 4415, 4457], 'conversion': [8, 198], 'normal,': [11, 201], 'cellular': [12, 202, 595, 690, 3540, 3993], 'protein': [14, 204, 419, 3088, 3151, 3665, 3766, 3776], '(PrPC)': [15, 205, 420], 'into': [16, 206, 459, 2847], 'β-sheet-rich': [17, 207], 'disease-related': [18, 208, 413], 'isoforms': [19, 209, 414], '(PrPSc),': [20, 210], 'deposition': [22, 212, 409, 1280], 'which': [24, 139, 214, 329, 575, 1278, 1505, 1675, 1887, 3028], 'thought': [26, 216, 577], 'to': [27, 29, 117, 217, 219, 307, 512, 578, 580, 849, 979, 1282, 1286, 1494, 1602, 1658, 1685, 2017, 2107, 2231, 2294, 2322, 2574, 2587, 2601, 2669, 2677, 2688, 2735, 2748, 2758, 2769, 2853, 2957, 2993, 3037, 3081, 3144, 3266, 3407, 3447, 3458, 3468, 3526, 3557, 3642, 3695, 3730, 3941], 'lead': [28, 218, 579], 'neurodegeneration.': [30, 220], 'In': [31, 108, 221, 298, 1160, 1364, 1595, 2045, 2752, 4154], 'present': [33, 223, 1162, 1366, 1386, 3276], 'study,': [34, 224], 'squalene': [36, 226, 1174, 3871], 'synthase': [37, 227, 1175, 3872], 'inhibitor': [38, 228, 903, 1172, 3869], 'squalestatin': [39, 66, 77, 94, 114, 229, 256, 267, 284, 304, 1801, 1967, 1995, 2005, 2022, 2349, 2636, 2644, 2779, 2869, 2875, 2886, 2975, 3007, 3016, 3698, 3930, 3952, 3982, 4012, 4061, 4101, 4122, 4166, 4204, 4348, 4396, 4443], 'reduced': [40, 230, 867, 3928, 3940, 4055], 'cholesterol': [42, 232, 797, 844, 913, 1047, 1097, 1178, 1516, 2009, 2012, 2015, 2649, 2881, 3021, 3663, 3754, 3878, 3994, 4016, 4042, 4078, 4160, 4185, 4193], 'content': [43, 233, 3666, 4043, 4079, 4148, 4248, 4266, 4280, 4295, 4310, 4324, 4370, 4417], 'cells': [45, 63, 235, 253, 863, 869, 1301, 1818, 1825, 1840, 1877, 1914, 1974, 1977, 2049, 2071, 2074, 2102, 2112, 2321, 2359, 2387, 2737, 2741, 2859, 2980, 3045, 3049, 3062, 3265, 3285, 3390, 3547, 3677, 3707, 3829, 3925, 3947, 3997, 4031, 4046, 4082, 4089, 4114, 4198, 4234, 4250, 4268, 4282, 4297, 4312, 4326, 4336, 4373, 4391, 4420, 4438], 'and': [46, 59, 102, 178, 236, 249, 292, 368, 397, 451, 510, 583, 585, 689, 798, 840, 970, 1231, 1235, 1422, 1451, 1740, 1815, 1843, 1846, 1862, 1871, 1891, 1910, 1929, 1933, 1943, 1959, 2037, 2066, 2105, 2119, 2145, 2149, 2171, 2223, 2372, 2421, 2441, 2469, 2490, 2496, 2502, 2509, 2518, 2527, 2582, 2645, 2686, 2692, 2767, 2802, 2836, 2851, 2912, 2952, 2991, 3017, 3113, 3132, 3305, 3309, 3330, 3373, 3413, 3433, 3464, 3489, 3510, 3520, 3573, 3636, 3660, 3664, 3692, 3717, 3752, 3788, 3834, 3955, 3967, 4004, 4087, 4192], 'prevented': [47, 237], 'accumulation': [49, 239, 1244, 1560, 3920], 'PrPSc': [51, 176, 241, 366, 464, 505, 536, 859, 1247, 1279, 1340, 1384, 1562, 1842, 1890], 'in': [52, 79, 152, 162, 174, 179, 242, 269, 342, 352, 364, 369, 401, 455, 463, 508, 540, 694, 705, 860, 912, 1039, 1226, 1239, 1248, 1387, 1563, 1600, 1667, 1672, 1734, 1752, 1849, 1896, 1946, 1985, 1989, 2052, 2084, 2116, 2128, 2177, 2184, 2210, 2258, 2341, 2362, 2375, 2397, 2460, 2475, 2514, 2631, 2672, 2742, 2825, 2908, 2988, 2999, 3010, 3032, 3122, 3194, 3277, 3288, 3353, 3370, 3375, 3395, 3420, 3430, 3435, 3545, 3570, 3598, 3604, 3679, 3688, 3821, 3916, 3923, 3931, 3945, 3962, 3968, 3991, 3999, 4048, 4084, 4091, 4112, 4140, 4151, 4207, 4339, 4413, 4461], 'three': [53, 243, 1227, 2471, 3368, 3428, 4241], 'prion-infected': [54, 244, 861, 1228, 1636, 1816, 4354], 'cell': [55, 245, 1229, 1921, 2109, 2816, 3771, 4356], 'lines': [56, 246, 4357], '(ScN2a,': [57, 247], 'SMB,': [58, 248], 'ScGT1': [60, 250, 1913, 1976, 3264, 4360, 4411, 4419, 4437], 'cells).': [61, 251], 'ScN2a': [62, 252, 2048, 2736, 2979, 3039, 3044, 3676, 3828, 3912, 3924, 3946, 3996, 4030, 4045, 4081, 4088, 4113, 4197], 'treated': [64, 112, 254, 302, 871, 1660, 2328, 2596, 2739, 2775, 3443, 3948, 4005, 4115, 4200, 4363, 4374, 4392, 4421, 4439], 'with': [65, 76, 113, 149, 159, 186, 255, 266, 303, 339, 349, 376, 407, 872, 1302, 1332, 1392, 1531, 1558, 1635, 1661, 1949, 2032, 2062, 2151, 2165, 2270, 2366, 2500, 2516, 2597, 2776, 2830, 2866, 2872, 2883, 3311, 3326, 3453, 3714, 3949, 4009, 4058, 4119, 4126, 4133, 4177, 4201, 4209, 4364, 4375, 4393, 4410, 4422, 4440], 'were': [67, 95, 97, 103, 257, 285, 287, 293, 870, 1828, 1847, 1894, 1934, 1944, 1978, 2029, 2050, 2092, 2103, 2113, 2218, 2239, 2252, 2314, 2327, 2360, 2388, 2473, 2481, 2512, 2543, 2595, 2626, 2667, 2684, 2707, 2756, 2773, 2800, 2840, 2860, 2906, 2962, 2981, 2997, 3030, 3063, 3127, 3261, 3286, 3359, 3391, 3425, 3445, 3487, 3515, 3522, 3602, 3631, 3638, 3667, 3708, 3727, 3802, 3939, 4199, 4222, 4408], 'also': [68, 258, 1057, 1511, 1888, 2315, 2963, 3182], 'protected': [69, 259], 'against': [70, 260], 'microglia-mediated': [71, 261, 2977], 'killing.': [72, 262], 'Treatment': [73, 263], 'neurons': [75, 111, 265, 301, 539, 695, 1637, 1659, 1684, 2542, 3216], 'resulted': [78, 268], 'a': [80, 125, 150, 168, 270, 315, 340, 358, 417, 446, 460, 500, 573, 901, 1170, 1252, 1379, 1383, 1452, 1668, 1729, 1803, 1829, 2185, 2234, 2242, 2289, 2427, 2476, 2503, 2639, 2659, 2781, 2795, 2899, 3011, 3023, 3114, 3123, 3186, 3195, 3336, 3349, 3364, 3408, 3416, 3448, 3459, 3527, 3574, 3581, 3605, 3643, 3932, 3989, 4340, 4376, 4423], 'redistribution': [81, 271], 'PrPC': [83, 273, 456, 596, 693, 702, 1238, 2324], 'away': [84, 274], 'from': [85, 275, 1335, 1373, 1744, 2275, 2317, 2545, 2709, 3204, 3263, 3280, 3387, 3474, 3495, 4237], 'Triton': [86, 276, 2342, 2431, 4462], 'X-100': [87, 277, 2343, 4463], 'insoluble': [88, 278, 2121, 2456], 'lipid': [89, 279, 706, 817], 'rafts.': [90, 280], 'These': [91, 165, 281, 355, 403, 1726, 1839], 'effects': [92, 282, 1086, 1095, 1167, 1514, 3782, 4346], 'dose-dependent,': [96, 286], 'evident': [98, 288], 'at': [99, 289, 1980, 2159, 2196, 2203, 2284, 2298, 2392, 2451, 2464, 2483, 2762, 2842, 2949, 2965, 2983, 3320, 3382, 3438, 3517, 3633, 3813], 'nanomolar': [100, 290], 'concentrations,': [101, 291], 'partially': [104, 130, 294, 320, 4161], 'reversed': [105, 141, 295, 331, 4162], 'by': [106, 142, 296, 332, 1277, 1298, 1504, 1924, 1936, 2081, 2248, 2268, 2288, 2306, 2955, 3129, 3134, 3363, 3393, 3475, 3503, 3524, 3548, 3640, 3710, 3929, 3988, 4056, 4104], 'cholesterol.': [107, 297, 3978, 4217], 'addition,': [109, 299], 'uninfected': [110, 300, 2355], 'became': [115, 305], 'resistant': [116, 306, 511], 'otherwise': [119, 309], 'toxic': [120, 310], 'effect': [121, 136, 311, 326, 1799, 1965, 2347, 2973, 3865, 3959, 3980, 4099, 4164], 'PrP': [123, 313, 518, 1376, 1603, 1664, 1686, 2477, 2808, 3068, 3207, 3358, 3365, 3424, 3441, 3460, 3533, 3832], 'peptides,': [124, 314, 2896], 'synthetic': [126, 316, 1380, 1453, 3200], 'miniprion': [127, 317, 1454, 3201], '(sPrP106)': [128, 318, 1455, 3202], 'or': [129, 319, 382, 708, 1005, 1331, 1632, 1663, 1819, 1975, 1992, 2013, 2019, 2072, 2378, 2425, 2638, 2658, 2738, 2780, 2810, 2871, 2882, 2898, 3002, 3009, 3675, 3687, 4124, 4132, 4206, 4213, 4359], 'purified': [131, 321, 3133, 3258], 'preparations.': [133, 323], 'The': [134, 324, 592, 813, 1290, 2124, 2179, 2191, 2206, 2455, 2856, 3041, 3402, 3484, 3584, 3650, 3935, 3979, 4041, 4218, 4368], 'protective': [135, 325, 4098], 'squalestatin,': [138, 328, 1169, 3867, 4190], 'was': [140, 330, 866, 2040, 2126, 2163, 2175, 2182, 2194, 2208, 2229, 2266, 2305, 2336, 2447, 2458, 2572, 2695, 2733, 2823, 2917, 2947, 3046, 3181, 3185, 3209, 3324, 3333, 3346, 3404, 3543, 3755, 3768, 3783, 3811, 3926, 3960, 3986, 4053, 4072, 4102, 4110, 4172, 4362, 4384, 4431], 'addition': [144, 334, 1655, 2652, 2789, 2894, 4157], 'water-soluble': [146, 336, 2014, 2648, 2880, 3020, 4130, 4159, 4216], 'cholesterol,': [147, 337, 4131], 'correlated': [148, 338], 'reduction': [151, 341, 1671], 'prostaglandin': [153, 343, 1520], 'E2': [154, 344], 'production': [155, 345, 699, 914, 1060, 1179, 1183, 1223, 1522, 2039, 3876, 3985, 4169, 4196], 'that': [156, 346, 391, 503, 594, 686, 792, 842, 1082, 1176, 1679, 1809, 2075, 2332, 3273, 3827, 3873, 3975, 4257, 4275, 4289, 4304, 4319, 4333, 4388, 4414, 4435], 'associated': [158, 185, 348, 375, 406, 1530], 'neuronal': [160, 188, 350, 378, 581, 1283, 1293, 1300, 1519, 1526, 1533, 1673, 1735, 1920, 2670, 2693, 2740, 2750], 'injury': [161, 351], 'disease.': [164, 354], 'studies': [166, 356, 1080, 1747, 2754, 3070, 3212, 3824, 4465], 'indicate': [167, 357], 'pivotal': [169, 359], 'role': [170, 360, 1731], 'for': [171, 361, 599, 1054, 1501, 1882, 2156, 2200, 2220, 2281, 2628, 2784, 2804, 2862, 3022, 3053, 3211, 3317, 3580, 3699, 3722, 4006, 4116], 'cholesterol-sensitive': [172, 362, 1497], 'processes': [173, 363, 1291, 1503], 'controlling': [175, 365], 'formation,': [177, 367, 1971], 'activation': [181, 371, 1555], 'signaling': [183, 373], 'pathways': [184, 374], 'PrP-induced': [187, 377, 1532], 'death.': [189, 379], 'Prion': [380, 2811, 3255], 'diseases,': [381], 'Transmissible': [383], 'Spongiform': [384], 'Encephalopathies': [385], '(TSEs),': [386], 'are': [387, 405, 974, 1091, 1499, 1528, 1915], 'fatal': [388], 'neurodegenerative': [389], 'disorders': [390], 'include': [392], 'Kuru,': [393], 'Creutzfeldt-Jakob': [394], 'disease': [395, 1008, 1751], '(CJD),': [396], 'Gerstman-Straussler-Scheinker': [398], '(GSS)': [399], 'syndrome': [400], 'man.': [402, 1040], 'aggregates': [411, 534], '(PrPSc)': [415], 'host-encoded': [418], 'within': [421], 'central': [423], 'nervous': [424], 'system': [425], '(1Williams': [426, 1755], 'A.': [427, 474, 491, 635, 637, 663, 667, 675, 771, 780, 875, 879, 936, 961, 1134, 1188, 1544, 1616, 1643, 1705, 1756, 1774, 2558, 2721, 2933, 2935, 3620, 3846, 3880], 'Lucassen': [428, 1757], 'P.J.': [429, 1758], 'Ritchie': [430, 1759], 'D.': [431, 476, 881, 887, 985, 1102, 1403, 1618, 1622, 1760, 2612, 2931, 3162], 'Bruce': [432, 1761], 'M.': [433, 468, 472, 545, 608, 620, 643, 665, 757, 877, 930, 1104, 1108, 1112, 1200, 1319, 1350, 1437, 1463, 1477, 1540, 1567, 1614, 1762, 1833, 3099, 3224, 3238, 3479, 3892], 'Exp.': [434, 1140, 1763], 'Neurol.': [435, 996, 1764], '1997;': [436, 805, 1765], '144:': [437, 1766], '433-438Crossref': [438, 1767], 'PubMed': [439, 495, 528, 568, 627, 653, 680, 784, 808, 835, 894, 965, 1000, 1019, 1034, 1074, 1120, 1216, 1269, 1326, 1359, 1417, 1446, 1489, 1549, 1590, 1627, 1648, 1699, 1721, 1768, 1790, 2563, 2620, 2726, 3108, 3176, 3250, 3625, 3749, 3858, 3908], 'Scopus': [440, 496, 529, 569, 628, 654, 681, 785, 809, 836, 895, 966, 1001, 1020, 1035, 1075, 1121, 1270, 1327, 1360, 1418, 1447, 1490, 1550, 1591, 1628, 1649, 1700, 1722, 1769, 1791, 2564, 2727, 3109, 3177, 3251, 3626], '(188)': [441, 1770], 'Google': [442, 498, 531, 571, 630, 656, 683, 787, 811, 838, 897, 968, 1003, 1022, 1037, 1077, 1123, 1144, 1158, 1217, 1272, 1329, 1362, 1420, 1449, 1492, 1552, 1593, 1630, 1651, 1702, 1724, 1771, 1793, 2566, 2621, 2729, 2943, 3111, 3179, 3253, 3628, 3750, 3859, 3909], 'Scholar).': [443, 532, 812, 898, 1078, 1159, 1363, 1553, 1594, 1652, 1725, 1794, 2567, 2622, 2730, 2944, 3254, 3629, 3860], 'During': [444], 'disease,': [445], 'portion': [447], 'α-helix': [450], 'random': [452], 'coil': [453], 'structure': [454], 'refolded': [458], 'β-pleated': [461], 'sheet': [462], '(2Pan': [465], 'K.M.': [466, 1067], 'Baldwin': [467], 'Nguyen': [469], 'J.': [470, 549, 829, 888, 918, 924, 928, 948, 952, 954, 1068, 1132, 1152, 1207, 1321, 1399, 1413, 1478, 1571, 2276, 2615, 3158, 3172, 3239, 3477, 3497, 3735, 3740, 3853, 3899], 'Gasset': [471], 'Serban': [473, 1402, 3161], 'Groth': [475], 'Mehlhorn': [477], 'I.': [478, 1713, 1782], 'Huang': [479], 'Z.': [480], 'Fletterick': [481], 'R.J.': [482, 1206, 3898], 'Cohen': [483], 'F.E.': [484], 'Proc.': [485, 774, 955], 'Natl.': [486, 775, 956], 'Acad.': [487, 776, 957], 'Sci.': [488, 777, 958], 'U.': [489, 778, 959, 991], 'S.': [490, 659, 661, 671, 759, 779, 940, 960, 983, 1538, 1542, 1610, 1641, 2556, 2719, 3618], '1993;': [492, 647, 1323, 1356, 1443, 3105], '90:': [493], '10962-10966Crossref': [494], '(2084)': [497], 'Scholar),': [499, 572, 788, 839, 1273, 1450, 3751, 3910], 'conformational': [501], 'change': [502], 'renders': [504], 'poorly': [506], 'soluble': [507], 'water': [509, 2118, 2501, 3354, 3372], 'protease': [513], 'digestion,': [514], 'resultant': [516], 'protease-resistant': [517, 1337, 3831], 'being': [519], 'designated': [520], 'PrPres': [521, 1225, 1822, 1932, 1970, 2038, 2265, 3819, 3922, 3938, 3984, 4108, 4150, 4168, 4195, 4221, 4323, 4350, 4369, 4382, 4416, 4429], '(3Prusiner': [522], 'S.B.': [523, 618, 773, 885, 1405, 3164, 3852], 'Science.': [524], '1982;': [525], '216:': [526], '136-144Crossref': [527], '(4124)': [530], 'Consequently,': [533], 'accumulate': [537], 'around': [538], 'affected': [541], 'brain': [542, 3282], 'areas': [543], '(4Jeffrey': [544, 1566], 'Halliday': [546, 1568], 'W.G.': [547, 1569], 'Bell': [548, 1570], 'Johnston': [550, 1572], 'A.R.': [551, 557, 1573, 1579], 'MacLeod': [552, 1574], 'N.K.': [553, 1575], 'Ingham': [554, 1576], 'C.': [555, 622, 645, 673, 926, 989, 1536, 1577, 1639, 1711, 1780, 2554, 2717, 3616], 'Sayers': [556, 1578], 'Brown': [558, 1580, 1706, 1775], 'D.A.': [559, 1581, 3838], 'Fraser': [560, 1582], 'J.R.': [561, 1583], 'Neuropathol.': [562, 1584], 'Appl.': [563, 1585], 'Neurobiol.': [564, 1586], '2000;': [565, 1587], '26:': [566, 1017, 1588], '41-54Crossref': [567, 1589], '(228)': [570, 1592], 'process': [574], 'dysfunction': [582], 'death,': [584], 'subsequently': [586, 2774], 'clinical': [588, 976], 'symptoms': [589], 'infection.': [591], 'observation': [593], 'essential': [598], 'development': [601], '(5Bueler': [605], 'H.': [606, 612, 633, 761, 932, 1309], 'Fischer': [607, 664], 'Lang': [609], 'Y.': [610, 669], 'Bluethmann': [611], 'Lipp': [613], 'H.P.': [614], 'DeArmond': [615, 764], 'S.J.': [616, 765], 'Prusiner': [617, 772, 884, 1404, 3163, 3851], 'Aguet': [619, 642], 'Weissmann': [621, 644, 672], 'Nature.': [623, 676, 804, 1355, 1442, 1695, 3104], '1992;': [624, 1210, 3902], '356:': [625], '577-582Crossref': [626], '(1441)': [629], 'Scholar,': [631, 657, 1023, 1124, 1145, 1703, 1772], '6Bueler': [632], 'Aguzzi': [634, 674], 'Sailer': [636, 666], 'Greiner': [638], 'R.A.': [639, 1012], 'Autenried': [640], 'P.': [641, 1110, 2929, 3478], 'Cell.': [646, 1069], '73:': [648], '1339-1347Abstract': [649], 'Full': [650, 1213, 1484, 1486, 3245, 3247, 3746, 3905], 'Text': [651, 1214, 1485, 1487, 3246, 3248, 3747, 3906], 'PDF': [652, 1215, 1488, 3249, 3748, 3907], '(1814)': [655], '7Brandner': [658], 'Isenmann': [660], 'Raeber': [662], 'Kobayashi': [668], 'Marino': [670], '1996;': [677, 781, 1696], '379:': [678], '339-343Crossref': [679], '(721)': [682], 'Scholar)': [684, 969, 1004, 1038, 1218, 1330, 1421, 1493, 1631, 3112, 3180], 'suggests': [685], 'density': [688, 2946], 'location': [691], 'may': [696, 3274], 'influence': [697, 850], 'PrPSc.': [701, 854], 'found': [704], 'rafts': [707, 818], 'caveolae-like': [709, 717], 'domains': [710], '(CLDs)': [711], '1The': [712], 'abbreviations': [713], 'used': [714, 978, 1369, 2093, 3064, 3210], 'are:': [715], 'CLD,': [716], 'domains;': [718], 'FCS,': [719, 1958], 'fetal': [720, 1867], 'calf': [721, 1868], 'serum;': [722], 'PMSF,': [723], 'phenylmethylsulfonyl': [724], 'fluoride;': [725], 'IL,': [726], 'interleukin;': [727], 'GFP,': [728], 'green': [729], 'fluorescent': [730], 'protein;': [731], 'MTT,': [732], '3-[4,5': [733, 2699], 'dimethylthiazol-2yl]-2,5-diphenyltetrazolium': [734], 'bromide;': [735], 'Me2SO,': [736], 'dimethyl': [737], 'sulfoxide;': [738], 'HMG-coA,': [739], '3-hydroxy-3-methylglutaryl-co-enzyme': [740, 905], 'A;': [741], 'PG,': [742], 'prostaglandin;': [743], 'mAb,': [744], 'monoclonal': [745], 'antibody;': [746], 'ELISA,': [747], 'enzyme-linked': [748, 2187], 'immunosorbent': [749, 2188], 'assay;': [750], 'HPLC,': [751], 'high': [752, 794], 'performance': [753], 'liquid': [754], 'chromatography.': [755], '(8Vey': [756], 'Pilkuhn': [758], 'Wille': [760], 'Nixon': [762], 'R.': [763, 938, 1010, 1346, 1433, 1461, 3095, 3222], 'Smart': [766], 'E.J.': [767], 'Anderson': [768, 827], 'R.G.': [769, 828], 'Taraboulos': [770, 3845], '93:': [782], '14945-14949Crossref': [783], '(489)': [786], 'specialized': [789], 'membrane': [790, 2245], 'compartments': [791], 'contain': [793, 3830], 'levels': [795, 845, 1234, 1524, 2961, 3542, 3944], 'sphingomyelin': [799], '(9Simons': [800], 'K.': [801, 950, 994], 'Ikonen': [802], 'E.': [803, 934, 942, 1348, 1435, 3097], '387:': [806], '569-572Crossref': [807], '(8157)': [810], 'formation': [814, 852, 857, 4109], 'these': [816], 'cholesterol-dependent': [820], '(10Rothberg': [821], 'K.G.': [822], 'Ying': [823], 'Y.S.': [824, 1136], 'Kamen': [825], 'B.A.': [826], 'Cell': [830, 889, 2821, 2915], 'Biol.': [831, 890, 1116, 1208, 1479, 3240, 3741, 3900], '1990;': [832], '111:': [833], '2931-2938Crossref': [834], '(454)': [837], 'drugs': [841], 'affect': [843, 4146], 'have': [846, 1295], 'been': [847, 1296, 2077, 3051], 'shown': [848, 3915], 'Thus,': [855, 1795], 'neuroblastoma': [862, 1817, 1824, 2358, 2814, 3061, 3073, 4355], '(ScN2a': [864, 1826], 'cells)': [865, 1827, 2091, 4361], 'when': [868, 1633], 'lovastatin': [873], '(11Taraboulos': [874], 'Scott': [876, 3839], 'Semenov': [878], 'Avrahami': [880], 'Laszlo': [882], 'L.': [883, 1100, 1130, 1147, 1467, 1471, 3228, 3232], 'Avraham': [886], '1995;': [891], '129:': [892], '121-132Crossref': [893], '(518)': [896], 'Lovastatin': [899], 'competitive': [902], '(HMG-CoA)': [907], 'reductase,': [908], 'rate-limiting': [910], 'step': [911], '(12Alberts': [915], 'A.W.': [916], 'Chen': [917], 'Kuron': [919], 'G.': [920, 944, 1342, 1429, 1465, 1473, 3091, 3226, 3234], 'Hunt': [921], 'V.': [922, 1457, 3218], 'Huff': [923], 'Hoffman': [925], 'Rothrock': [927], 'Lopez': [929], 'Joshua': [931], 'Harris': [933], 'Patchett': [935], 'Monaghan': [937], 'Currie': [939], 'Stapley': [941], 'Albers-Schonberg': [943], 'Hensens': [945], 'O.': [946, 1352, 1401, 1439, 3101, 3160], 'Hirshfield': [947], 'Hoogsteen': [949], 'Liesch': [951], 'Springer': [953], '1980;': [962], '77:': [963], '3957-3961Crossref': [964], '(1465)': [967], 'HMG-CoA': [971, 1043, 1088], 'reductase': [972, 1044, 1089], 'inhibitors': [973, 1045, 1090], 'useful': [975], 'tools': [977], 'treat': [980], 'hypercholesterolemia': [981], '(13Locatelli': [982], 'Lutjohann': [984], 'Schmidt': [986, 1691], 'H.H.': [987], 'Otto': [988], 'Beisiegel': [990], 'von': [992], 'Bergmann': [993], 'Arch.': [995, 1137], '2002;': [997, 1155, 1481, 1546, 3242], '59:': [998], '213-216Crossref': [999], '(151)': [1002], 'ischemic': [1006], 'heart': [1007], '(14Chilton': [1009], "O'Rourke": [1011], 'Curr.': [1013], 'Probl.': [1014], 'Cardiol.': [1015], '2001;': [1016, 1031, 1117, 1645, 2560, 2723, 3622], '734-764Crossref': [1018], '(7)': [1021], '15Jones': [1024], 'S.P.': [1025], 'Lefer': [1026], 'D.J.': [1027], 'Acta': [1028], 'Physiol.': [1029, 1070, 1153], 'Scand.': [1030], '173:': [1032], '139-143Crossref': [1033], '(45)': [1036], 'However,': [1041], 'although': [1042, 4170], 'reduce': [1046, 2602, 3267], 'levels,': [1048], 'they': [1049, 1056], 'exhibit': [1050], 'many': [1051, 1083], 'other': [1052, 2753, 4353], 'effects,': [1053], 'example,': [1055], 'inhibit': [1058], 'isoprenoid': [1062], 'precursors': [1063], '(16Maltese': [1064], 'W.A.': [1065], 'Sheridan': [1066], '1987;': [1071], '133:': [1072], '471-481Crossref': [1073], '(98)': [1076], 'Recent': [1079], 'suggest': [1081, 1728], 'independent': [1092], 'their': [1094, 2510], 'on': [1096, 1221, 1232, 1518, 1681, 1802, 1968, 2233, 2350, 2390, 2976, 3213, 3406, 3565, 3669, 3770, 3911, 3983, 4167, 4194, 4349, 4456], 'metabolism': [1098], '(17Diomede': [1099], 'Albani': [1101], 'Sottocorno': [1103], 'Donati': [1105], 'M.B.': [1106, 3737], 'Bianchi': [1107], 'Fruscella': [1109], 'Salmona': [1111, 1349, 1436, 1476, 1613, 3098, 3237], 'Arterioscler.': [1113], 'Thromb.': [1114], 'Vasc.': [1115], '21:': [1118], '1327-1332Crossref': [1119], '(211)': [1122], '18Danesh': [1125], 'F.R.': [1126], 'Anel': [1127], 'R.L.': [1128], 'Zeng': [1129], 'Lomasney': [1131], 'Sahai': [1133], 'Kanwar': [1135], 'Immunol.': [1138], 'Ther.': [1139], '2003;': [1141], '51:': [1142, 2941], '139-148PubMed': [1143], '19Kalinowski': [1146], 'Dobrucki': [1148], 'I.T.': [1149], 'Malinski': [1150], 'T.': [1151, 1459, 3220], 'Pharmacol.': [1154, 1322], '53:': [1156], '585-595PubMed': [1157], 'study': [1163, 1367], 'we': [1164, 1368, 1796, 3862], 'investigated': [1165, 1797, 3863], 'specific': [1171], 'inhibits': [1177, 3874], 'without': [1180], 'affecting': [1181], 'non-sterol': [1185], 'products': [1186], '(20Baxter': [1187, 3879], 'Fitzgerald': [1189, 3881], 'B.J.': [1190, 3882], 'Hutson': [1191, 3883], 'J.L.': [1192, 3884], 'McCarthy': [1193, 3885], 'A.D.': [1194, 3886], 'Motteram': [1195, 3887], 'J.M.': [1196, 1313, 1606, 3842, 3888], 'Ross': [1197, 3889], 'B.C.': [1198, 3890], 'Sapra': [1199, 3891], 'Snowden': [1201, 3893], 'M.A.': [1202, 3894], 'Watson': [1203, 3895], 'N.S.': [1204, 3896], 'Williams': [1205, 1543, 1615, 1642, 2557, 2720, 3619, 3897], 'Chem.': [1209, 1480, 3241, 3742, 3901], '267:': [1211, 3903], '11705-11708Abstract': [1212, 3904], '(Fig.': [1219, 3953], '1),': [1220], 'lines,': [1230], 'distribution': [1236, 2352], 'non-infected': [1240, 2319, 3066, 3388], 'cells.': [1241, 2751, 2959, 3040, 3913, 4153], 'Although': [1242], 'aggregated': [1246], 'CNS': [1250, 1565], 'distinguishing': [1253], '(21Bruce': [1258], 'M.E.': [1259], 'McBride': [1260], 'P.A.': [1261], 'Farquhar': [1262], 'C.F.': [1263], 'Neurosci.': [1264, 2616], 'Lett.': [1265], '1989;': [1266], '102:': [1267], '1-6Crossref': [1268], '(245)': [1271], 'precise': [1275], 'mechanisms': [1276], 'leads': [1281], 'damage': [1284], 'remain': [1285], 'be': [1287, 3275], 'fully': [1288, 4174], 'determined.': [1289], 'loss': [1294, 1736], 'examined': [1297, 1512], 'incubating': [1299], 'either': [1303, 2398, 2865, 3680], 'preparations': [1305, 3279, 3386], '(22Müller': [1306], 'W.E.': [1307], 'Ushijima': [1308], 'Schroder': [1310], 'H.C.': [1311], 'Forrest': [1312], 'Schatton': [1314], 'W.F.': [1315], 'Rytik': [1316], 'P.G.': [1317], 'Heffner-Lauc': [1318], 'Eur.': [1320], '246:': [1324], '261-267Crossref': [1325], '(157)': [1328], 'peptides': [1333, 1371, 1604, 1665, 1687, 2654, 3076, 3461], 'derived': [1334, 1372, 3203], 'core': [1338], '(23Forloni': [1341, 1428, 3090], 'Angeretti': [1343, 1430, 1468, 3092, 3229], 'N.': [1344, 1431, 1469, 3093, 3230], 'Chiesa': [1345, 1432, 1460, 3094, 3221], 'Monzani': [1347, 1434, 3096], 'Bugiani': [1351, 1400, 1438, 3100, 3159], 'Tagliavini': [1353, 1440, 1474, 1611, 3102, 3235], 'F.': [1354, 1395, 1397, 1441, 1475, 1612, 3103, 3154, 3156, 3236], '362:': [1357, 1444, 3106], '543-546Crossref': [1358, 1445, 3107], '(896)': [1361, 1448, 3110], 'two': [1370, 3789, 4352], 'human': [1375, 2813, 3072, 3086, 3149], 'protein,': [1377, 4023], 'HuPrP(82–146),': [1378], 'equivalent': [1381], 'fragment': [1385], 'brains': [1389], 'patients': [1391], 'GSS': [1393], '(24Tagliavini': [1394, 3153], 'Prelli': [1396, 3155], 'Ghiso': [1398, 3157], 'Farlow': [1406, 3165], 'M.R.': [1407, 2937, 3166, 3840], 'Ghetti': [1408, 3167], 'B.': [1409, 1411, 1692, 3168, 3170], 'Frangione': [1410, 3169], 'EMBO': [1412, 3171], '1991;': [1414, 2940, 3173], '10:': [1415, 1625, 3174], '513-519Crossref': [1416, 3175], '(171)': [1419, 3178], 'truncated,': [1424], 'neurotoxic': [1425], 'version': [1426], 'HuPrP-(106–126)': [1427], '(25Bonetto': [1456, 3217], 'Massignan': [1458, 3219], 'Morbin': [1462, 3223], 'Mazzoleni': [1464, 3225], 'Diomede': [1466, 3227], 'Colombo': [1470, 3231], 'Forloni': [1472, 3233], '277:': [1482, 3243], '31327-31334Abstract': [1483, 3244], '(33)': [1491, 3252], 'investigate': [1495, 2971, 4095], 'if': [1496], 'microdomains': [1498], 'required': [1500], 'prions': [1506, 1662], 'kill': [1507], 'infected': [1508, 1923, 3281], 'neurons.': [1509, 1821, 2679], 'We': [1510], 'manipulation': [1517], '(PG)E2': [1521], 'since': [1523], 'PGE2': [1527, 2960, 3537, 3541, 3569, 3579], 'closely': [1529], 'death': [1534], '(26Bate': [1535], 'Rutherford': [1537], 'Gravenor': [1539], 'Reid': [1541, 1640, 2555, 2718, 3617], 'Neuroreport.': [1545, 1623, 1644, 2559, 2722, 3621], '13:': [1547], '1933-1938Crossref': [1548], '(30)': [1551], 'Microglial': [1554], 'frequently': [1556], 'co-localizes': [1557], 'vitro,': [1596], 'microglia': [1597, 1657, 1733, 1814, 2607, 2666, 2676, 2732, 2747, 2755, 3029, 3036, 3601], 'secrete': [1598], 'cytokines': [1599], 'response': [1601], '(27Peyrin': [1605], 'Lasmezas': [1607], 'C.I.': [1608], 'Haik': [1609], 'Richie': [1617], 'Deslys': [1619], 'J.P.': [1620], 'Dormont': [1621], '1999;': [1624], '723-729Crossref': [1626], '(113)': [1629], 'incubated': [1634], '(28Bate': [1638, 2553, 2716, 3615], '12:': [1646, 2561, 2724, 3623], '2589-2594Crossref': [1647, 2562, 2725, 3624], '(43)': [1650, 2565, 2728, 3627], 'Moreover,': [1653], 'results': [1666, 2953, 3521, 3637, 4407], 'significant': [1669, 1730, 4074], 'further': [1670, 2609, 2796, 3024], 'survival,': [1674], 'greater': [1677], 'than': [1678, 4027, 4256, 4274, 4288, 4303, 4318, 4332, 4387, 4434], 'seen': [1680], 'exposure': [1682, 3694], 'only': [1688], '(29Brown': [1689], 'D.R.': [1690, 1707, 1776, 3844], 'Kretzschmar': [1693, 1714, 1783], 'H.A.': [1694, 1715, 1784], '380:': [1697], '345-347Crossref': [1698], '(499)': [1701], '30Giese': [1704, 1773], 'Groschup': [1708, 1777], 'M.H.': [1709, 1778], 'Feldmann': [1710, 1779], 'Haist': [1712, 1781], 'Brain': [1716, 1785], 'Pathol.': [1717, 1786], '1998;': [1718, 1787], '8:': [1719, 1788], '449-457Crossref': [1720, 1789], '(207)': [1723, 1792], 'observations': [1727], 'during': [1737], 'support': [1741], 'interpretations': [1742], 'drawn': [1743], 'time': [1745, 2967], 'course': [1746], 'experimental': [1749], 'rodent': [1753], 'models': [1754], 'second': [1804, 2192], 'model': [1805], 'prion-induced': [1807], 'neurodegeneration': [1808], 'involves': [1810], 'interaction': [1812], 'between': [1813, 3567, 4076], 'PrP-damaged': [1820], 'Production—Scrapie-infected': [1823], 'gift': [1830, 2274, 3473], 'Dr.': [1832, 1937, 3476], 'Rogers': [1834], '(University': [1835], 'College,': [1836], 'Dublin,': [1837], 'Ireland).': [1838], 'produce': [1841, 1889], 'infectious': [1844, 1892, 3835], 'agent,': [1845, 1893], 'grown': [1848, 1895, 1945, 2031, 2051, 2824, 3678, 3998, 4047, 4083, 4090], 'Hams': [1850, 3681, 3969], 'F12': [1851, 3682, 3970], 'medium': [1852, 1899, 2056, 2571, 2828, 3683, 3966, 3971, 4000, 4086], 'containing': [1853, 1900, 2132, 2261, 2403, 2429, 2576, 2633, 3077, 3140, 3189, 3292, 3357, 3398, 3423, 3600, 3684, 3972, 4001], '2': [1854, 1903, 1950, 2063, 2367, 2569, 2579, 2831, 3954], 'mm': [1855, 1904, 1951, 2064, 2134, 2137, 2140, 2167, 2368, 2405, 2410, 2413, 2423, 2434, 2437, 2443, 2580, 2832, 3294, 3297, 3300, 3328, 3400], 'glutamine,': [1856, 1905, 1952, 2369, 2833], 'standard': [1857, 1901, 1960, 2370, 2504, 2834, 3528, 3644], 'antibiotics': [1858, 2835], '(100': [1859], 'units/ml': [1860], 'penicillin': [1861], '100': [1863, 2003, 2020, 2136, 2381, 2409, 2634, 2642, 2777, 2873, 2884, 3005, 3014, 3296, 3383, 3439, 3696, 3950, 4010, 4059, 4120, 4182, 4202, 4365, 4394, 4441], 'μg/ml': [1864, 2008, 2153, 2647, 2878, 3019, 3313, 4128, 4183, 4215], 'streptomycin),': [1865], '2%': [1866, 1911, 2373, 2837, 3685, 3973, 4002, 4092], 'serum': [1869], '(FCS)': [1870], '200': [1872, 1906, 1953], 'nm': [1873, 1907, 1954, 2004, 2021, 2382, 2635, 2643, 2778, 2868, 2874, 2885, 3006, 3015, 3697, 3951, 4011, 4060, 4121, 4203, 4366, 4395, 4442], 'retinoic': [1874, 1908, 1955], 'acid.': [1875], 'SMB': [1876, 1973, 2073, 4372, 4390], '(TSE': [1878], 'Resource': [1879], 'Centre,': [1880], 'Institute': [1881], 'Animal': [1883], 'Health,': [1884], 'Compton,': [1885], 'UK),': [1886, 2002], 'RPMI': [1897, 2363, 2826], '1640': [1898, 2364, 2827], 'antibiotics,': [1902, 2371], 'acid,': [1909, 1956], 'FCS.': [1912, 2838, 4093], 'an': [1916, 2129, 2400, 3289, 3504, 3511, 3550, 3758, 3868], 'immortalized': [1917], 'murine': [1918, 2356, 3206, 3214, 3532, 3648], 'hypothalamic': [1919], 'line': [1922, 2817], 'scrapie': [1926], 'Chandler': [1927], 'strain': [1928], 'persistently': [1930], 'express': [1931], 'supplied': [1935, 2497], 'Sylvain': [1938], 'Lehmann': [1939], '(CNRS-IGH,': [1940], 'Montpellier,': [1941], 'France)': [1942, 2280], 'optimem': [1947], 'supplemented': [1948, 2061, 2365, 2829], '5%': [1957, 3815], 'antibiotics.': [1961], 'To': [1962, 4094, 4343], 'measure': [1963], 'ScN2a,': [1972], 'plated': [1979, 2841, 2982], '1': [1981, 2157, 2282, 2393, 2465, 2488, 2675, 2746, 2763, 2984, 3035, 3318, 3670], '×': [1982, 2198, 2394, 2453, 2466, 2764, 2844, 2985, 3671, 3720, 4232], '105': [1983, 2765, 2986], 'cells/well': [1984, 2766, 2846, 2987], '6-well': [1986], 'microtiter': [1987, 2849], 'plates': [1988, 2761, 2850, 2990], 'presence': [1991, 2086, 2377, 3001], 'absence': [1993, 2379, 3003], 'alone': [1996, 2637, 2870, 4123, 4205], '(0–100': [1997], 'nm)': [1998], '(GlaxoSmithKline,': [1999], 'Stevenage,': [2000], 'Herts,': [2001], 'plus': [2006, 2023, 2876, 2887], '1–100': [2007, 2646, 2877, 3018, 4127, 4214], '(either': [2010], 'free': [2011], 'complexed': [2016], 'methyl-β-cyclodextrin)(Sigma),': [2018], '500': [2024, 2888, 4134, 4210], 'μm': [2025, 2584, 2889, 4135, 4211], 'mevalonate': [2026, 4143, 4212], '(Sigma).': [2027], 'Cells': [2028, 2326, 2839, 2996], 'then': [2030], 'daily': [2033], 'changes': [2034], 'media': [2036, 2632], 'evaluated': [2041, 4111], 'after': [2042, 2449, 3027, 3048, 3693], '8': [2043], 'days.': [2044], 'some': [2046], 'studies,': [2047], 'serum-free': [2054, 3689, 4085], 'neurobasal': [2055], '(NBM)': [2057], '(Invitrogen,': [2058], 'Paisley,': [2059], 'UK)': [2060, 3611], 'glutamine': [2065, 2581], 'B27': [2067, 2577], 'components.': [2068], 'Non-infected': [2069], 'N2a': [2070, 2320, 2357, 3060, 3389], 'had': [2076, 3050, 3825], '"cured"': [2078], 'infectivity': [2080], 'serial': [2082], 'passages': [2083], 'pentosan': [2088], 'polysulphate': [2089], '(PS': [2090], 'as': [2094, 2329, 2550, 2713, 3065, 3184, 3612, 3795, 3804, 4224], 'controls.': [2095, 3067], 'At': [2096, 3702], 'end': [2098, 3704], 'treatment,': [2101], 'detached': [2104, 3709], 'counted': [2106], 'establish': [2108], 'numbers.': [2110], 'Washed': [2111, 3284], 'first': [2114, 2180], 'lysed': [2115, 2389], 'distilled': [2117, 3371, 3431], 'pellet': [2122, 2125, 2207, 2457], 'collected.': [2123], 'suspended': [2127, 3287], 'extraction': [2130, 2401, 2461, 3290, 3396], 'buffer': [2131, 2215, 2402, 2428, 2462, 3291, 3397], '10': [2133, 2139, 2152, 2404, 2412, 2436, 2678, 2749, 2791, 3038, 3293, 3299, 3312, 3723], 'Tris-HCl,': [2135, 2406, 2438, 3295], 'NaCl,': [2138, 2411, 2435, 3298], 'EDTA,': [2141, 2414, 3301], '0.5%': [2142, 2146, 2415, 2418, 3302, 3306], 'Nonidet': [2143, 2416, 3303], 'P-40,': [2144, 2417], 'sodium': [2147, 2419, 3307], 'deoxycholate': [2148, 3308], 'digested': [2150, 3310], 'proteinase': [2154, 2333, 3315], 'K': [2155, 2334, 3316], 'h': [2158, 2202, 2283, 2297, 2630, 2786, 2798, 2864, 2920, 3026, 3055, 3319, 4008, 4118], '37': [2160, 3321], '°C.': [2161, 2205, 3322], 'Digestion': [2162, 3323], 'stopped': [2164, 3325], '5': [2166, 2221, 2422, 2442, 2583, 2598, 3327, 3399], 'phenylmethanesulfonyl': [2168], 'fluoride': [2169], '(PMSF)': [2170], 'remaining': [2173], 'supernatant': [2174, 3332, 3403], 'split': [2176], 'two.': [2178], 'sample': [2181, 2193, 2228, 3572], 'tested': [2183, 2474, 2803, 3362], 'PrP-specific': [2186], 'assay': [2189, 3562, 3589, 3655, 3760], '(ELISA).': [2190], 'centrifuged': [2195], '50,000': [2197], 'g': [2199, 3721], '4': [2201, 2204, 2681], 'dissolved': [2209, 2459], '50': [2211, 4398, 4445], 'μl': [2212, 2225], 'Laemmli': [2214], '(Bio-Rad).': [2216], 'Samples': [2217, 3486], 'boiled': [2219], 'min': [2222], '20': [2224, 3591, 3657], 'each': [2227], 'subjected': [2230], 'electrophoresis': [2232], '15%': [2235], 'polyacrylamide': [2236], 'gel.': [2237], 'Proteins': [2238], 'transferred': [2240], 'onto': [2241, 3335], 'Hybond-P': [2243], 'PVDF': [2244], '(Amersham': [2246, 2311, 3554], 'Biosciences)': [2247, 3555], 'semi-dry': [2249], 'blotting.': [2250], 'Membranes': [2251], 'blocked': [2253], 'using': [2254, 2697, 2922, 3056, 3071, 3491, 3549, 3757, 3773, 3786], '10%': [2255], 'milk': [2256], 'powder': [2257], 'Tris-buffered': [2259], 'saline': [2260, 3381, 3437], '0.2%': [2262], 'Tween': [2263], '20.': [2264], 'detected': [2267], 'incubation': [2269], 'mab': [2271], 'SAF83': [2272, 3493], '(a': [2273, 3472], 'Grassi,': [2277], 'CEA,': [2278], 'Saclay,': [2279, 3500], 'room': [2285, 2299], 'temperature,': [2286], 'followed': [2287, 3502], 'secondary': [2290], 'anti-mouse': [2291, 3505], 'IgG': [2292], 'conjugated': [2293, 3467], 'peroxidase': [2295], '(1': [2296], 'temperature).': [2300], 'Detection': [2301], 'bound': [2303], 'antibody': [2304], 'enhanced': [2308], 'chemiluminescence': [2309], 'kit': [2310, 3553, 3761], 'Biosciences).': [2312], 'Lysates': [2313], 'made': [2316, 2907], 'evaluate': [2323], 'content.': [2325], 'above': [2330], 'except': [2331], 'digestion': [2335], 'excluded.': [2337], 'Solubility': [2338, 4458], 'PrPc': [2340, 4460], '—To': [2344], 'determine': [2345], 'PrPC,': [2354], 'maintained': [2361], 'FCS': [2374, 3686, 3974, 4003], 'squalestatin.': [2383, 4367], 'After': [2384, 2568, 2662, 2680, 2794], '3': [2385, 2629, 2664, 2785, 2843, 2863], 'days': [2386], 'ice': [2391], '107': [2395, 2467, 3672, 4233], 'cells/ml': [2396], '(a)': [2399, 2463], 'pH': [2407, 2439, 3378], '7.8,': [2408, 2440], 'deoxycholate,': [2420], 'PMSF': [2424, 3329], '(b)': [2426], '1%': [2430], 'X-100,': [2432], '150': [2433], 'PMSF.': [2444, 3401], 'Soluble': [2445], 'material': [2446, 3345], 'collected': [2448, 2801], 'centrifugation': [2450], '10,000': [2452], 'g.': [2454], 'cells/ml,': [2468], 'all': [2470, 3807], 'supernatants': [2472, 2799], 'ELISA.': [2478], 'Animals—129/Ola': [2479], 'mice': [2480, 2549, 2712], 'housed': [2482], 'constant': [2484], 'temperature': [2485], '(21': [2486], '±': [2487, 2494, 4018, 4025, 4033, 4051, 4063, 4235, 4245, 4261, 4263, 4293, 4308, 4380, 4427], '°C)': [2489], 'relative': [2491], 'humidity': [2492], '(60': [2493], '10%)': [2495], 'ad': [2498], 'libitum': [2499], 'diet.': [2505], 'Procedures': [2506], 'involving': [2507], 'animals': [2508], 'care': [2511], 'conducted': [2513], 'accordance': [2515], 'national': [2517], 'international': [2519], 'regulations': [2520], '(Animals': [2521], '(Scientific': [2522], 'Procedures)': [2523], 'Act,': [2524], '1986,': [2525], 'UK,': [2526], 'EEC': [2528], 'Council': [2529], 'Directive': [2530], '86609,': [2531], 'OJ': [2532], 'L358,': [2533], '1,': [2534], '12': [2535], 'December': [2536], '1987).': [2537], 'Primary': [2538], 'Neuronal': [2539], 'Cultures—Primary': [2540], 'cortical': [2541, 3215], 'prepared': [2544, 2708], 'embryonic': [2546], 'day': [2547], '15.5': [2548], 'previously': [2551, 2714, 3613], 'described': [2552, 2715, 3614], 'days,': [2570, 2682], 'changed': [2573], 'NBM': [2575, 3965, 4049], 'components,': [2578], 'cytosine': [2585], 'arabinoside': [2586], 'prevent': [2588], 'proliferation': [2590], 'astroglia.': [2592], 'Mature': [2593], 'cultures': [2594, 2625, 2671, 2683, 2706, 3599], 'mml-leucine': [2599], 'methylester': [2600], 'number': [2604, 3269], 'contaminating': [2606], 'before': [2608, 2650, 2787, 2892, 3691], 'use': [2610], '(31Giulian': [2611], 'Baker': [2613], 'T.J.': [2614], '1986;': [2617], '6:': [2618], '2163-2178Crossref': [2619], 'For': [2623, 3806], 'experiments,': [2624], 'preincubated': [2627], 'mixture': [2640, 3012], '(HuPrP-(82–146),': [2655], 'HuPrP-(106–126),': [2656], 'sPrP106,': [2657], 'extract.': [2661, 2902], 'another': [2663], 'h,': [2665], 'added': [2668, 2734, 2757, 3031, 3446], 'ratio': [2674, 2744, 3034], 'shaken': [2685], 'washed': [2687, 3367, 3427, 3712], 'remove': [2689], 'non-adherent': [2690], 'microglia,': [2691], 'viability': [2694, 2916], 'determined': [2696, 2918, 2964, 3544, 3668, 3756, 3769, 4223], 'dimethylthiazol-2yl]-2,5': [2700], 'diphenyltetrazolium': [2701], 'bromide': [2702], '(MTT)': [2703], 'method.': [2704, 3059], 'Microglia—Microglia': [2705], 'newborn': [2710], '129/Ola': [2711], 'Isolated': [2731], '96-well': [2759, 2848], 'flat-bottomed': [2760], 'allowed': [2768, 2852, 2992], 'adhere': [2770, 2854, 2994], 'overnight.': [2771, 2855, 2995], 'Microglia': [2772], 'vehicle': [2782, 4377, 4424], 'control': [2783, 3187, 4378, 4425], 'ng/ml': [2792], 'lipopolysaccharide.': [2793], '24': [2797, 2919, 3025, 3054, 4007, 4117], 'IL-6.': [2805, 3649], 'Neurotoxicity': [2806], 'Peptides': [2809], 'Preparations—The': [2812], 'SH-SY5Y': [2815, 3546, 3673], '(European': [2818], 'Collection': [2819], 'Cultures)': [2822], '104': [2845], 'following': [2857], 'day,': [2858], 'pretreated': [2861], '0–100': [2867], 'mevalonate,': [2891, 4191], 'sPrP106': [2897], 'diluted': [2900, 2913, 3454], 'Squalestatin': [2903, 3817, 4455], 'stock': [2904], 'solutions': [2905], 'di-methyl': [2909], 'sulfoxide': [2910], '(Me2SO)': [2911], 'appropriately.': [2914], 'later': [2921], 'MTT': [2924, 3058], 'method': [2925], '(32Vistica': [2926], 'D.T.': [2927, 3850], 'Skehan': [2928], 'Scudiero': [2930], 'Monks': [2932], 'Pittman': [2934], 'Boyd': [2936], 'Cancer': [2938], 'Res.': [2939], '2515-2520PubMed': [2942], 'Optical': [2945], 'measured': [2948, 3047], '595': [2950], 'nm,': [2951, 3519, 3635], 'calculated': [2954, 3523, 3639], 'reference': [2956, 3525, 3641], 'untreated': [2958, 4029, 4259, 4277, 4291, 4306, 4321, 4335], 'this': [2966, 3588, 3654], 'point.': [2968], 'Microglia-mediated': [2969], 'Toxicity—To': [2970], 'toxicity,': [2978], '24-well': [2989], 'cultured': [2998], 'alone,': [3008], 'survival': [3042], 'co-cultured': [3052], 'Peptides—For': [3069], '(SH-SY5Y)': [3074], 'cells,': [3075, 3674, 4412], 'amino': [3078, 3120, 3141, 3190], 'acids': [3079, 3121, 3142], 'corresponding': [3080, 3143], 'residues': [3082, 3145, 3192], '106–126': [3083], '(HuPrP-(106–126))': [3089], 'peptide': [3115, 3139, 3188], 'consisting': [3116], 'same': [3119], 'scrambled': [3124, 3196], 'order': [3125], '(HuPrP-(106–126scrambled))': [3126], 'synthesized': [3128], 'solid-phase': [3130], 'chemistry': [3131], 'reverse-phase': [3135], 'HPLC.': [3136], 'longer': [3138], '82–146': [3146, 3193], '(HuPrP-(82–146))': [3152], 'used,': [3183], 'acid': [3191], 'sequence': [3197, 3208], '(HuPrP-(82–146scrambled)).': [3198], 'Extract': [3256], 'Preparations—Partially': [3257], 'extracts': [3260], 'obtained': [3262], 'potential': [3271], 'contaminants': [3272], 'material.': [3283], 'P-40': [3304], 'loaded': [3334, 3405], 'prewashed': [3337, 3409], 'C18': [3338, 3410], 'Sep-Pak': [3339, 3411], 'column': [3340, 3412], '(Waters,': [3341], 'Elstree,': [3342], 'UK).': [3343], 'Bound': [3344], 'eluted': [3347, 3414], 'under': [3348, 3415], 'gradient': [3350, 3417], 'n-propanol': [3352, 3419], '(5–100%),': [3355], 'fractions': [3356], 'pooled': [3360], '(samples': [3361], 'ELISA),': [3366], 'times': [3369, 3429, 4242], 'resuspended': [3374, 3434], '0.01': [3376], 'm': [3377], '7.4': [3379], 'phosphate-buffered': [3380, 3436, 3715], 'ng/ml.': [3384, 3440], 'Control': [3385], 'produced': [3392], 'lysis': [3394], 'water.': [3421], 'Fractions': [3422], 'pooled,': [3426], 'water,': [3432], 'ELISA—Briefly,': [3442], 'lysates': [3444, 3772], 'Nunc': [3449], 'Maxisorb': [3450], 'Immunoplates': [3451], 'precoated': [3452], 'rabbit': [3455], 'antiserum': [3456], 'raised': [3457], '(ovine': [3462], 'PrP-(27–52)': [3463], 'ovine': [3465], 'PrP-(100–111))': [3466], 'keyhole': [3469], 'limpet': [3470], 'hemocyanin': [3471], 'Langeveld,': [3480], 'Pepscan': [3481], 'Systems,': [3482, 3609], 'Lelystad,': [3483], 'Netherlands).': [3485], 'applied': [3488], 'visualized': [3490], 'mAb': [3492], '(gift': [3494], 'Prof.': [3496], 'Grassi': [3498], '(CEA,': [3499], 'France),': [3501], 'IgG-alkaline': [3506], 'phosphatase': [3507], 'conjugate': [3508], '(Sigma)': [3509], 'appropriate': [3512], 'indicator.': [3513], 'Plates': [3514, 3630], 'read': [3516, 3632], '450': [3518, 3634], 'curve': [3529, 3645], 'recombinant': [3531, 3647], '(Prionics,': [3534], 'Zurich,': [3535], 'Switzerland).': [3536], 'Assay—Analysis': [3538], 'enzyme': [3551], 'immunoassay': [3552], 'according': [3556, 3729], "manufacturer's": [3559], 'instructions.': [3560], 'This': [3561, 3958], 'based': [3564], 'competition': [3566], 'unlabeled': [3568], 'fixed': [3575], 'amount': [3576], 'labeled': [3578], 'PGE2-specific': [3582], 'antibody.': [3583], 'detection': [3585, 3651], 'limit': [3586, 3652], 'pg/ml.': [3592, 3658], 'IL-6': [3593], 'ELISA—Levels': [3594], 'interleukin': [3596], '(IL)-6': [3597], 'assayed': [3603], 'sandwich': [3606], 'ELISA': [3607], '(R&D': [3608], 'Abingdon,': [3610], 'Cholesterol': [3659], 'Protein': [3661], 'Content—Cellular': [3662], 'NBM,': [3690], '3–24': [3700], 'h.': [3701], 'incubation,': [3706], 'trypsinization,': [3711], 'twice': [3713], 'saline,': [3716], 'pelleted': [3718], '(550': [3719], 'min).': [3724], 'Total': [3725], 'lipids': [3726], 'extracted': [3728], 'Folch': [3731], 'et': [3732], 'al.': [3733], '(33Folch': [3734], 'Lees': [3736], 'Sloane-Stanley': [3738], 'G.H.': [3739], '1957;': [3743], '226:': [3744], '497-509Abstract': [3745], 'total': [3753], 'enzymatic': [3759], '(Roche': [3762], 'Applied': [3763], 'Science).': [3764], 'Cellular': [3765], 'concentration': [3767], 'Bio-Rad': [3775], 'assay.': [3777], 'Statistical': [3778], 'Analysis—Comparison': [3779], 'treatment': [3781, 4057], 'carried': [3784], 'out': [3785], 'one': [3787], 'way': [3790], 'analysis': [3791], 'variance': [3793], 'techniques': [3794], 'appropriate.': [3796], 'Post': [3797], 'hoc': [3798], 'comparisons': [3799], 'means': [3801], 'performed': [3803], 'necessary.': [3805], 'statistical': [3808], 'tests': [3809], 'significance': [3810], 'set': [3812], 'level.': [3816], 'Reduces': [3818], 'Formation': [3820], 'Prion-infected': [3822], 'Cells—Previous': [3823], 'indicated': [3826], '(PrPres)': [3833], 'agent': [3836], '(34Butler': [3837], 'Bockman': [3841], 'Borchelt': [3843], 'Hsiao': [3847], 'K.K.': [3848], 'Kingsbury': [3849], 'Virol.': [3854], '1988;': [3855], '62:': [3856], '1558-1564Crossref': [3857], 'Here,': [3861], 'As': [3914, 4138], 'Fig.': [3917], '2,': [3918], 'significantly': [3927, 4014, 4251, 4269, 4283, 4298, 4313, 4327, 4385, 4432], 'dose-dependent': [3933], 'manner.': [3934], 'amounts': [3936, 4219], 'below': [3942], 'detectable': [3943], 'Table': [3956, 4141], 'I).': [3957], 'observed': [3961, 4409], 'both': [3963], 'lipid-depleted': [3964], 'contained': [3976, 4013], 'extracellular': [3977], 'accompanied': [3987], 'decrease': [3990], 'levels.': [3995], 'less': [4015, 4252, 4270, 4284, 4299, 4314, 4328], '(0.262': [4017], '0.040': [4019], 'μg': [4020], 'cholesterol/mg': [4022], 'mean': [4024, 4230], 'S.D.)': [4026], 'did': [4028, 4144], '(0.509': [4032], '0.041,': [4034], 'n': [4035, 4065, 4400, 4447], '=': [4036, 4066, 4401, 4448], '6,': [4037, 4067], 'p': [4038, 4068, 4403, 4450], '<': [4039, 4069, 4254, 4272, 4286, 4301, 4316, 4330, 4404, 4451], '0.05).': [4040, 4070, 4405, 4452], '(0.484': [4050], '0.033)': [4052], 'greatly': [4054], '(0.181': [4062], '0.025,': [4064], 'There': [4071], 'no': [4073], 'difference': [4075], 'whether': [4096], 'mediated': [4103], 'sterol': [4105], 'derivatives,': [4106], 'combined': [4125], 'mevalonate.': [4137], 'reported': [4139], 'I,': [4142], 'not': [4145, 4173], 'squalestatin-treated': [4152], 'contrast,': [4155], 'it': [4171], 'restored': [4175], 'even': [4176], 'higher': [4179, 4386, 4433], 'dose': [4180], '(Table': [4186], 'I).Table': [4187], 'IEffects': [4188], 'combination': [4208], 'described.': [4225], 'Each': [4226], 'value': [4227], 'PrPres/1': [4231], 'S.D.': [4236], 'triplicate': [4238], 'experiments': [4239], 'repeated': [4240], '(9': [4243], 'observations).SqualestatinMevalonateCholesterolPrPresnmμmμg/mlpg/ml0001830': [4244], '14510000<': [4246], '50aPrPres': [4247, 4265, 4279], '(p': [4253, 4271, 4285, 4300, 4315, 4329], '0.01)': [4255, 4273, 4287, 4302, 4317, 4331], 'cells050001844': [4260], '147001001867': [4262], '1931005000<': [4264], 'cells10001<': [4278], 'cells10001092': [4292], '75aPrPres': [4294], 'cells10001001033': [4307], '166aPrPres': [4309], 'cellsa': [4322], 'Open': [4337], 'table': [4338], 'new': [4341], 'tab': [4342], 'confirm': [4344], 'production,': [4351], '(SMB': [4358], '(7,405': [4379], '512': [4381], 'pg/ml)': [4383, 4430], '(<': [4397, 4444], 'pg/ml,': [4399, 4446], '8,': [4402, 4449], 'Similar': [4406], '(10,014': [4426], '845': [4428], 'Effect': [4453], '—Previous': [4464], 'showe': [4466]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1969771853', 'counts_by_year': [{'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-10T15:34:46.012030', 'created_date': '2016-06-24'}