Leukocyte Infiltration, Neuronal Degeneration, and Neurite Outgrowth after Ablation of Scar-Forming, Reactive Astrocytes in Adult Transgenic Mice

Name: Work Video:
Duration: 3 min 30 s
Toby G. Bush; Narman Puvanachandra; Catherine H. Horner; Anabella Polito; Thor Ostenfeld; Clive N. Svendsen; Lennart Mucke; Martin H. Johnson; Michael V. Sofroniew
{'id': 'https://openalex.org/W1969619562', 'doi': 'https://doi.org/10.1016/s0896-6273(00)80781-3', 'title': 'Leukocyte Infiltration, Neuronal Degeneration, and Neurite Outgrowth after Ablation of Scar-Forming, Reactive Astrocytes in Adult Transgenic Mice', 'display_name': 'Leukocyte Infiltration, Neuronal Degeneration, and Neurite Outgrowth after Ablation of Scar-Forming, Reactive Astrocytes in Adult Transgenic Mice', 'publication_year': 1999, 'publication_date': '1999-06-01', 'ids': {'openalex': 'https://openalex.org/W1969619562', 'doi': 'https://doi.org/10.1016/s0896-6273(00)80781-3', 'mag': '1969619562', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10399936'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0896-6273(00)80781-3', 'pdf_url': 'https://www.cell.com/article/S0896627300807813/pdf', 'source': {'id': 'https://openalex.org/S45757444', 'display_name': 'Neuron', 'issn_l': '0896-6273', 'issn': ['0896-6273', '1097-4199'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310315673', 'https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Cell Press', 'Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.cell.com/article/S0896627300807813/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5068842573', 'display_name': 'Toby G. Bush', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I90344618', 'display_name': 'Medical Research Council', 'ror': 'https://ror.org/03x94j517', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}, {'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Toby G Bush', 'raw_affiliation_strings': ['Department of Anatomy, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, United Kingdom', 'Medical Research Council Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Medical Research Council Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, United Kingdom', 'institution_ids': ['https://openalex.org/I90344618', 'https://openalex.org/I241749']}, {'raw_affiliation_string': 'Department of Anatomy, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, United Kingdom', 'institution_ids': ['https://openalex.org/I241749']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007685500', 'display_name': 'Narman Puvanachandra', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I90344618', 'display_name': 'Medical Research Council', 'ror': 'https://ror.org/03x94j517', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}, {'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Narman Puvanachandra', 'raw_affiliation_strings': ['Department of Anatomy, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, United Kingdom', 'Medical Research Council Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Medical Research Council Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, United Kingdom', 'institution_ids': ['https://openalex.org/I90344618', 'https://openalex.org/I241749']}, {'raw_affiliation_string': 'Department of Anatomy, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, United Kingdom', 'institution_ids': ['https://openalex.org/I241749']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050358550', 'display_name': 'Catherine H. Horner', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I90344618', 'display_name': 'Medical Research Council', 'ror': 'https://ror.org/03x94j517', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}, {'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Catherine H Horner', 'raw_affiliation_strings': ['Department of Anatomy, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, United Kingdom', 'Medical Research Council Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Medical Research Council Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, United Kingdom', 'institution_ids': ['https://openalex.org/I90344618', 'https://openalex.org/I241749']}, {'raw_affiliation_string': 'Department of Anatomy, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, United Kingdom', 'institution_ids': ['https://openalex.org/I241749']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023590061', 'display_name': 'Anabella Polito', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I90344618', 'display_name': 'Medical Research Council', 'ror': 'https://ror.org/03x94j517', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}, {'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Anabella Polito', 'raw_affiliation_strings': ['Department of Anatomy, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, United Kingdom', 'Medical Research Council Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Medical Research Council Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, United Kingdom', 'institution_ids': ['https://openalex.org/I90344618', 'https://openalex.org/I241749']}, {'raw_affiliation_string': 'Department of Anatomy, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, United Kingdom', 'institution_ids': ['https://openalex.org/I241749']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026040566', 'display_name': 'Thor Ostenfeld', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I90344618', 'display_name': 'Medical Research Council', 'ror': 'https://ror.org/03x94j517', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}, {'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Thor Ostenfeld', 'raw_affiliation_strings': ['Medical Research Council Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Medical Research Council Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, United Kingdom', 'institution_ids': ['https://openalex.org/I90344618', 'https://openalex.org/I241749']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076105306', 'display_name': 'Clive N. Svendsen', 'orcid': 'https://orcid.org/0000-0001-8696-3446'}, 'institutions': [{'id': 'https://openalex.org/I90344618', 'display_name': 'Medical Research Council', 'ror': 'https://ror.org/03x94j517', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}, {'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Clive N Svendsen', 'raw_affiliation_strings': ['Medical Research Council Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Medical Research Council Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, United Kingdom', 'institution_ids': ['https://openalex.org/I90344618', 'https://openalex.org/I241749']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065986296', 'display_name': 'Lennart Mucke', 'orcid': 'https://orcid.org/0000-0001-6256-9559'}, 'institutions': [{'id': 'https://openalex.org/I1321430492', 'display_name': 'Gladstone Institutes', 'ror': 'https://ror.org/038321296', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1321430492']}, {'id': 'https://openalex.org/I180670191', 'display_name': 'University of California, San Francisco', 'ror': 'https://ror.org/043mz5j54', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I180670191']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lennart Mucke', 'raw_affiliation_strings': ['The Gladstone Molecular Neurobiology Program and Department of Neurology, University of California, San Francisco, San Francisco, California 94141, USA'], 'affiliations': [{'raw_affiliation_string': 'The Gladstone Molecular Neurobiology Program and Department of Neurology, University of California, San Francisco, San Francisco, California 94141, USA', 'institution_ids': ['https://openalex.org/I1321430492', 'https://openalex.org/I180670191']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040901685', 'display_name': 'Martin H. Johnson', 'orcid': 'https://orcid.org/0000-0002-5906-5883'}, 'institutions': [{'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Martin H Johnson', 'raw_affiliation_strings': ['Department of Anatomy, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Department of Anatomy, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, United Kingdom', 'institution_ids': ['https://openalex.org/I241749']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5011858801', 'display_name': 'Michael V. Sofroniew', 'orcid': 'https://orcid.org/0000-0001-6075-0178'}, 'institutions': [{'id': 'https://openalex.org/I90344618', 'display_name': 'Medical Research Council', 'ror': 'https://ror.org/03x94j517', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I90344618']}, {'id': 'https://openalex.org/I241749', 'display_name': 'University of Cambridge', 'ror': 'https://ror.org/013meh722', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I241749']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'Michael V Sofroniew', 'raw_affiliation_strings': ['Department of Anatomy, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, United Kingdom', 'Medical Research Council Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, United Kingdom'], 'affiliations': [{'raw_affiliation_string': 'Medical Research Council Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, United Kingdom', 'institution_ids': ['https://openalex.org/I90344618', 'https://openalex.org/I241749']}, {'raw_affiliation_string': 'Department of Anatomy, University of Cambridge, Forvie Site, Robinson Way, Cambridge CB2 2PY, United Kingdom', 'institution_ids': ['https://openalex.org/I241749']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5011858801'], 'corresponding_institution_ids': ['https://openalex.org/I90344618', 'https://openalex.org/I241749'], 'apc_list': {'value': 9080, 'currency': 'USD', 'value_usd': 9080, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 4.749, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 1071, 'citation_normalized_percentile': {'value': 0.960208, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '23', 'issue': '2', 'first_page': '297', 'last_page': '308'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10608', 'display_name': 'Neurogenesis and neuroplasticity mechanisms', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/2806', 'display_name': 'Developmental Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10608', 'display_name': 'Neurogenesis and neuroplasticity mechanisms', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/2806', 'display_name': 'Developmental Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12061', 'display_name': 'Axon Guidance and Neuronal Signaling', 'score': 0.9965, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10483', 'display_name': 'Nerve injury and regeneration', 'score': 0.9958, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/neurite', 'display_name': 'Neurite', 'score': 0.7943543}, {'id': 'https://openalex.org/keywords/infiltration', 'display_name': 'Infiltration (HVAC)', 'score': 0.71638775}, {'id': 'https://openalex.org/keywords/glial-scar', 'display_name': 'Glial scar', 'score': 0.4544322}, {'id': 'https://openalex.org/keywords/degeneration', 'display_name': 'Degeneration (medical)', 'score': 0.41989}, {'id': 'https://openalex.org/keywords/neuronal-degeneration', 'display_name': 'Neuronal Degeneration', 'score': 0.41428363}], 'concepts': [{'id': 'https://openalex.org/C113246987', 'wikidata': 'https://www.wikidata.org/wiki/Q1534415', 'display_name': 'Neurite', 'level': 3, 'score': 0.7943543}, {'id': 'https://openalex.org/C153400128', 'wikidata': 'https://www.wikidata.org/wiki/Q3150731', 'display_name': 'Infiltration (HVAC)', 'level': 2, 'score': 0.71638775}, {'id': 'https://openalex.org/C141035611', 'wikidata': 'https://www.wikidata.org/wiki/Q5532934', 'display_name': 'Genetically modified mouse', 'level': 4, 'score': 0.6959403}, {'id': 'https://openalex.org/C2777542381', 'wikidata': 'https://www.wikidata.org/wiki/Q502961', 'display_name': 'Astrocyte', 'level': 3, 'score': 0.46280593}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.45615283}, {'id': 'https://openalex.org/C2777594495', 'wikidata': 'https://www.wikidata.org/wiki/Q5569540', 'display_name': 'Glial scar', 'level': 4, 'score': 0.4544322}, {'id': 'https://openalex.org/C169760540', 'wikidata': 'https://www.wikidata.org/wiki/Q207011', 'display_name': 'Neuroscience', 'level': 1, 'score': 0.45347056}, {'id': 'https://openalex.org/C102230213', 'wikidata': 'https://www.wikidata.org/wiki/Q430117', 'display_name': 'Transgene', 'level': 3, 'score': 0.43775895}, {'id': 'https://openalex.org/C2779354088', 'wikidata': 'https://www.wikidata.org/wiki/Q15467261', 'display_name': 'Degeneration (medical)', 'level': 2, 'score': 0.41989}, {'id': 'https://openalex.org/C2992208609', 'wikidata': 'https://www.wikidata.org/wiki/Q1755122', 'display_name': 'Neuronal degeneration', 'level': 3, 'score': 0.41428363}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3812421}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3300373}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.21391693}, {'id': 'https://openalex.org/C529278444', 'wikidata': 'https://www.wikidata.org/wiki/Q47273', 'display_name': 'Central nervous system', 'level': 2, 'score': 0.13796756}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.08318463}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.051306546}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.05052343}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C97355855', 'wikidata': 'https://www.wikidata.org/wiki/Q11473', 'display_name': 'Thermodynamics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001253', 'descriptor_name': 'Astrocytes', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D001930', 'descriptor_name': 'Brain Injuries', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D007962', 'descriptor_name': 'Leukocytes', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D009410', 'descriptor_name': 'Nerve Degeneration', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D016501', 'descriptor_name': 'Neurites', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D014951', 'descriptor_name': 'Wounds, Stab', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001253', 'descriptor_name': 'Astrocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001253', 'descriptor_name': 'Astrocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001812', 'descriptor_name': 'Blood-Brain Barrier', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001930', 'descriptor_name': 'Brain Injuries', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002452', 'descriptor_name': 'Cell Count', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015774', 'descriptor_name': 'Ganciclovir', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015774', 'descriptor_name': 'Ganciclovir', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005786', 'descriptor_name': 'Gene Expression Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005904', 'descriptor_name': 'Glial Fibrillary Acidic Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005904', 'descriptor_name': 'Glial Fibrillary Acidic Protein', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D005904', 'descriptor_name': 'Glial Fibrillary Acidic Protein', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D006624', 'descriptor_name': 'Hippocampus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006624', 'descriptor_name': 'Hippocampus', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D006651', 'descriptor_name': 'Histocytochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007962', 'descriptor_name': 'Leukocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007962', 'descriptor_name': 'Leukocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009410', 'descriptor_name': 'Nerve Degeneration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016501', 'descriptor_name': 'Neurites', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016501', 'descriptor_name': 'Neurites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018139', 'descriptor_name': 'Simplexvirus', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018139', 'descriptor_name': 'Simplexvirus', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D018139', 'descriptor_name': 'Simplexvirus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013937', 'descriptor_name': 'Thymidine Kinase', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D013937', 'descriptor_name': 'Thymidine Kinase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D013937', 'descriptor_name': 'Thymidine Kinase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014951', 'descriptor_name': 'Wounds, Stab', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0896-6273(00)80781-3', 'pdf_url': 'https://www.cell.com/article/S0896627300807813/pdf', 'source': {'id': 'https://openalex.org/S45757444', 'display_name': 'Neuron', 'issn_l': '0896-6273', 'issn': ['0896-6273', '1097-4199'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310315673', 'https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Cell Press', 'Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10399936', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/s0896-6273(00)80781-3', 'pdf_url': 'https://www.cell.com/article/S0896627300807813/pdf', 'source': {'id': 'https://openalex.org/S45757444', 'display_name': 'Neuron', 'issn_l': '0896-6273', 'issn': ['0896-6273', '1097-4199'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315673', 'host_organization_name': 'Cell Press', 'host_organization_lineage': ['https://openalex.org/P4310315673', 'https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Cell Press', 'Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 57, 'referenced_works': ['https://openalex.org/W1508738567', 'https://openalex.org/W1558441296', 'https://openalex.org/W1571970387', 'https://openalex.org/W1586855301', 'https://openalex.org/W1593655973', 'https://openalex.org/W1635850624', 'https://openalex.org/W1880770180', 'https://openalex.org/W1898526558', 'https://openalex.org/W1965733793', 'https://openalex.org/W1966756004', 'https://openalex.org/W1968143827', 'https://openalex.org/W1971054448', 'https://openalex.org/W1973558008', 'https://openalex.org/W1976623136', 'https://openalex.org/W1987831613', 'https://openalex.org/W1989197038', 'https://openalex.org/W1994185969', 'https://openalex.org/W2002751737', 'https://openalex.org/W2005648670', 'https://openalex.org/W2006289803', 'https://openalex.org/W2010654244', 'https://openalex.org/W2022225676', 'https://openalex.org/W2027024295', 'https://openalex.org/W2029905908', 'https://openalex.org/W2032123628', 'https://openalex.org/W2034038906', 'https://openalex.org/W2034507194', 'https://openalex.org/W2038280189', 'https://openalex.org/W2038774790', 'https://openalex.org/W2044175751', 'https://openalex.org/W2049884771', 'https://openalex.org/W2051393924', 'https://openalex.org/W2061021155', 'https://openalex.org/W2062392962', 'https://openalex.org/W2069739793', 'https://openalex.org/W2070784200', 'https://openalex.org/W2071369096', 'https://openalex.org/W2071490280', 'https://openalex.org/W2076996133', 'https://openalex.org/W2081959205', 'https://openalex.org/W2087666006', 'https://openalex.org/W2087916050', 'https://openalex.org/W2099675490', 'https://openalex.org/W2105056821', 'https://openalex.org/W2110681397', 'https://openalex.org/W2118309500', 'https://openalex.org/W2118513878', 'https://openalex.org/W2127338217', 'https://openalex.org/W2128744963', 'https://openalex.org/W2139155172', 'https://openalex.org/W2146548756', 'https://openalex.org/W2152353759', 'https://openalex.org/W2328115233', 'https://openalex.org/W2415198084', 'https://openalex.org/W2419412515', 'https://openalex.org/W310193716', 'https://openalex.org/W3215981791'], 'related_works': ['https://openalex.org/W4399020513', 'https://openalex.org/W4313198403', 'https://openalex.org/W3208076795', 'https://openalex.org/W3038756284', 'https://openalex.org/W2381638252', 'https://openalex.org/W2078014172', 'https://openalex.org/W2014463750', 'https://openalex.org/W1983216462', 'https://openalex.org/W1966242116', 'https://openalex.org/W179580088'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1969619562', 'counts_by_year': [{'year': 2024, 'cited_by_count': 39}, {'year': 2023, 'cited_by_count': 44}, {'year': 2022, 'cited_by_count': 49}, {'year': 2021, 'cited_by_count': 52}, {'year': 2020, 'cited_by_count': 59}, {'year': 2019, 'cited_by_count': 46}, {'year': 2018, 'cited_by_count': 62}, {'year': 2017, 'cited_by_count': 49}, {'year': 2016, 'cited_by_count': 58}, {'year': 2015, 'cited_by_count': 67}, {'year': 2014, 'cited_by_count': 64}, {'year': 2013, 'cited_by_count': 56}, {'year': 2012, 'cited_by_count': 57}], 'updated_date': '2024-12-29T00:11:34.273298', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
