Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1969542161', 'doi': 'https://doi.org/10.1084/jem.184.2.519', 'title': 'Regulation of pre-T cell receptor (pT alpha-TCR beta) gene expression during human thymic development.', 'display_name': 'Regulation of pre-T cell receptor (pT alpha-TCR beta) gene expression during human thymic development.', 'publication_year': 1996, 'publication_date': '1996-08-01', 'ids': {'openalex': 'https://openalex.org/W1969542161', 'doi': 'https://doi.org/10.1084/jem.184.2.519', 'mag': '1969542161', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/8760805', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2192728'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1084/jem.184.2.519', 'pdf_url': 'https://rupress.org/jem/article-pdf/184/2/519/1108726/519.pdf', 'source': {'id': 'https://openalex.org/S22947807', 'display_name': 'The Journal of Experimental Medicine', 'issn_l': '0022-1007', 'issn': ['0022-1007', '1540-9538'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://rupress.org/jem/article-pdf/184/2/519/1108726/519.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5010713127', 'display_name': 'Almudena R. Ramiro', 'orcid': 'https://orcid.org/0000-0002-7539-3844'}, 'institutions': [{'id': 'https://openalex.org/I134820265', 'display_name': 'Consejo Superior de Investigaciones Científicas', 'ror': 'https://ror.org/02gfc7t72', 'country_code': 'ES', 'type': 'government', 'lineage': ['https://openalex.org/I134820265']}, {'id': 'https://openalex.org/I4210146061', 'display_name': 'Centro de Biología Molecular Severo Ochoa', 'ror': 'https://ror.org/03v9e8t09', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210146061']}, {'id': 'https://openalex.org/I63634437', 'display_name': 'Universidad Autónoma de Madrid', 'ror': 'https://ror.org/01cby8j38', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I63634437']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'A R Ramiro', 'raw_affiliation_strings': ['Centro de Biología Molecular Severo Ochoa, CSIC: Consejo Superior de Investigaciones Cientificas, Facultad de Biología, Universidad Autónoma de Madrid Cantoblanco, Madrid, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Centro de Biología Molecular Severo Ochoa, CSIC: Consejo Superior de Investigaciones Cientificas, Facultad de Biología, Universidad Autónoma de Madrid Cantoblanco, Madrid, Spain.', 'institution_ids': ['https://openalex.org/I134820265', 'https://openalex.org/I4210146061', 'https://openalex.org/I63634437']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013647267', 'display_name': 'César Trigueros', 'orcid': 'https://orcid.org/0000-0001-8378-1663'}, 'institutions': [{'id': 'https://openalex.org/I4210146061', 'display_name': 'Centro de Biología Molecular Severo Ochoa', 'ror': 'https://ror.org/03v9e8t09', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210146061']}, {'id': 'https://openalex.org/I63634437', 'display_name': 'Universidad Autónoma de Madrid', 'ror': 'https://ror.org/01cby8j38', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I63634437']}, {'id': 'https://openalex.org/I134820265', 'display_name': 'Consejo Superior de Investigaciones Científicas', 'ror': 'https://ror.org/02gfc7t72', 'country_code': 'ES', 'type': 'government', 'lineage': ['https://openalex.org/I134820265']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'C Trigueros', 'raw_affiliation_strings': ['Centro de Biología Molecular Severo Ochoa, CSIC: Consejo Superior de Investigaciones Cientificas, Facultad de Biología, Universidad Autónoma de Madrid Cantoblanco, Madrid, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Centro de Biología Molecular Severo Ochoa, CSIC: Consejo Superior de Investigaciones Cientificas, Facultad de Biología, Universidad Autónoma de Madrid Cantoblanco, Madrid, Spain.', 'institution_ids': ['https://openalex.org/I4210146061', 'https://openalex.org/I63634437', 'https://openalex.org/I134820265']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026988185', 'display_name': 'Carlos Márquez', 'orcid': 'https://orcid.org/0000-0002-8166-8605'}, 'institutions': [{'id': 'https://openalex.org/I4210146061', 'display_name': 'Centro de Biología Molecular Severo Ochoa', 'ror': 'https://ror.org/03v9e8t09', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210146061']}, {'id': 'https://openalex.org/I63634437', 'display_name': 'Universidad Autónoma de Madrid', 'ror': 'https://ror.org/01cby8j38', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I63634437']}, {'id': 'https://openalex.org/I134820265', 'display_name': 'Consejo Superior de Investigaciones Científicas', 'ror': 'https://ror.org/02gfc7t72', 'country_code': 'ES', 'type': 'government', 'lineage': ['https://openalex.org/I134820265']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'C Márquez', 'raw_affiliation_strings': ['Centro de Biología Molecular Severo Ochoa, CSIC: Consejo Superior de Investigaciones Cientificas, Facultad de Biología, Universidad Autónoma de Madrid Cantoblanco, Madrid, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Centro de Biología Molecular Severo Ochoa, CSIC: Consejo Superior de Investigaciones Cientificas, Facultad de Biología, Universidad Autónoma de Madrid Cantoblanco, Madrid, Spain.', 'institution_ids': ['https://openalex.org/I4210146061', 'https://openalex.org/I63634437', 'https://openalex.org/I134820265']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112527847', 'display_name': 'J L San Millán', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210146061', 'display_name': 'Centro de Biología Molecular Severo Ochoa', 'ror': 'https://ror.org/03v9e8t09', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210146061']}, {'id': 'https://openalex.org/I63634437', 'display_name': 'Universidad Autónoma de Madrid', 'ror': 'https://ror.org/01cby8j38', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I63634437']}, {'id': 'https://openalex.org/I134820265', 'display_name': 'Consejo Superior de Investigaciones Científicas', 'ror': 'https://ror.org/02gfc7t72', 'country_code': 'ES', 'type': 'government', 'lineage': ['https://openalex.org/I134820265']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'J L San Millán', 'raw_affiliation_strings': ['Centro de Biología Molecular Severo Ochoa, CSIC: Consejo Superior de Investigaciones Cientificas, Facultad de Biología, Universidad Autónoma de Madrid Cantoblanco, Madrid, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Centro de Biología Molecular Severo Ochoa, CSIC: Consejo Superior de Investigaciones Cientificas, Facultad de Biología, Universidad Autónoma de Madrid Cantoblanco, Madrid, Spain.', 'institution_ids': ['https://openalex.org/I4210146061', 'https://openalex.org/I63634437', 'https://openalex.org/I134820265']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5083181264', 'display_name': 'Marı́a L. Toribio', 'orcid': 'https://orcid.org/0000-0002-8637-0373'}, 'institutions': [{'id': 'https://openalex.org/I63634437', 'display_name': 'Universidad Autónoma de Madrid', 'ror': 'https://ror.org/01cby8j38', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I63634437']}, {'id': 'https://openalex.org/I134820265', 'display_name': 'Consejo Superior de Investigaciones Científicas', 'ror': 'https://ror.org/02gfc7t72', 'country_code': 'ES', 'type': 'government', 'lineage': ['https://openalex.org/I134820265']}, {'id': 'https://openalex.org/I4210146061', 'display_name': 'Centro de Biología Molecular Severo Ochoa', 'ror': 'https://ror.org/03v9e8t09', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I4210146061']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'M L Toribio', 'raw_affiliation_strings': ['Centro de Biología Molecular Severo Ochoa, CSIC: Consejo Superior de Investigaciones Cientificas, Facultad de Biología, Universidad Autónoma de Madrid Cantoblanco, Madrid, Spain.'], 'affiliations': [{'raw_affiliation_string': 'Centro de Biología Molecular Severo Ochoa, CSIC: Consejo Superior de Investigaciones Cientificas, Facultad de Biología, Universidad Autónoma de Madrid Cantoblanco, Madrid, Spain.', 'institution_ids': ['https://openalex.org/I63634437', 'https://openalex.org/I134820265', 'https://openalex.org/I4210146061']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 6.107, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 72, 'citation_normalized_percentile': {'value': 0.863865, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '184', 'issue': '2', 'first_page': '519', 'last_page': '530'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12856', 'display_name': 'Transgenic Plants and Applications', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12856', 'display_name': 'Transgenic Plants and Applications', 'score': 0.9968, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11491', 'display_name': 'CAR-T cell therapy research', 'score': 0.9943, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11016', 'display_name': 'Monoclonal and Polyclonal Antibodies Research', 'score': 0.9929, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/thymocyte', 'display_name': 'Thymocyte', 'score': 0.73382497}, {'id': 'https://openalex.org/keywords/beta', 'display_name': 'BETA (programming language)', 'score': 0.53718746}, {'id': 'https://openalex.org/keywords/alpha', 'display_name': 'Alpha (finance)', 'score': 0.41955855}], 'concepts': [{'id': 'https://openalex.org/C19317047', 'wikidata': 'https://www.wikidata.org/wiki/Q412037', 'display_name': 'T-cell receptor', 'level': 4, 'score': 0.9074353}, {'id': 'https://openalex.org/C167672396', 'wikidata': 'https://www.wikidata.org/wiki/Q417800', 'display_name': 'CD8', 'level': 3, 'score': 0.75811434}, {'id': 'https://openalex.org/C2778954852', 'wikidata': 'https://www.wikidata.org/wiki/Q7799635', 'display_name': 'Thymocyte', 'level': 4, 'score': 0.73382497}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6447884}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.5600447}, {'id': 'https://openalex.org/C2776174256', 'wikidata': 'https://www.wikidata.org/wiki/Q830842', 'display_name': 'BETA (programming language)', 'level': 2, 'score': 0.53718746}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.4229473}, {'id': 'https://openalex.org/C64943373', 'wikidata': 'https://www.wikidata.org/wiki/Q2651003', 'display_name': 'Alpha (finance)', 'level': 4, 'score': 0.41955855}, {'id': 'https://openalex.org/C2992881475', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T lymphocyte', 'level': 3, 'score': 0.41343692}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.35013384}, {'id': 'https://openalex.org/C147483822', 'wikidata': 'https://www.wikidata.org/wiki/Q103537', 'display_name': 'Antigen', 'level': 2, 'score': 0.26147583}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.24284792}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.12388918}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.073830515}, {'id': 'https://openalex.org/C49453240', 'wikidata': 'https://www.wikidata.org/wiki/Q1592163', 'display_name': 'Construct validity', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C159110408', 'wikidata': 'https://www.wikidata.org/wiki/Q121176', 'display_name': 'Nursing', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C2775944032', 'wikidata': 'https://www.wikidata.org/wiki/Q22907659', 'display_name': 'Patient satisfaction', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C199360897', 'wikidata': 'https://www.wikidata.org/wiki/Q9143', 'display_name': 'Programming language', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D015332', 'descriptor_name': 'Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D015333', 'descriptor_name': 'Gene Rearrangement, beta-Chain T-Cell Antigen Receptor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D018398', 'descriptor_name': 'Homeodomain Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D016693', 'descriptor_name': 'Receptors, Antigen, T-Cell, alpha-beta', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D016176', 'descriptor_name': 'T-Lymphocyte Subsets', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D013950', 'descriptor_name': 'Thymus Gland', 'qualifier_ui': 'Q000254', 'qualifier_name': 'growth & development', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002453', 'descriptor_name': 'Cell Cycle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017931', 'descriptor_name': 'DNA Primers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017931', 'descriptor_name': 'DNA Primers', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D018507', 'descriptor_name': 'Gene Expression Regulation, Developmental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008562', 'descriptor_name': 'Membrane Glycoproteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011506', 'descriptor_name': 'Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016693', 'descriptor_name': 'Receptors, Antigen, T-Cell, alpha-beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017386', 'descriptor_name': 'Sequence Homology, Amino Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016176', 'descriptor_name': 'T-Lymphocyte Subsets', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013950', 'descriptor_name': 'Thymus Gland', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D013950', 'descriptor_name': 'Thymus Gland', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013950', 'descriptor_name': 'Thymus Gland', 'qualifier_ui': 'Q000196', 'qualifier_name': 'embryology', 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1084/jem.184.2.519', 'pdf_url': 'https://rupress.org/jem/article-pdf/184/2/519/1108726/519.pdf', 'source': {'id': 'https://openalex.org/S22947807', 'display_name': 'The Journal of Experimental Medicine', 'issn_l': '0022-1007', 'issn': ['0022-1007', '1540-9538'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2192728', 'pdf_url': 'https://europepmc.org/articles/pmc2192728?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-sa', 'license_id': 'https://openalex.org/licenses/cc-by-nc-sa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192728', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/8760805', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1084/jem.184.2.519', 'pdf_url': 'https://rupress.org/jem/article-pdf/184/2/519/1108726/519.pdf', 'source': {'id': 'https://openalex.org/S22947807', 'display_name': 'The Journal of Experimental Medicine', 'issn_l': '0022-1007', 'issn': ['0022-1007', '1540-9538'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315676', 'host_organization_name': 'Rockefeller University Press', 'host_organization_lineage': ['https://openalex.org/P4310315676'], 'host_organization_lineage_names': ['Rockefeller University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 42, 'referenced_works': ['https://openalex.org/W1479717491', 'https://openalex.org/W1505667323', 'https://openalex.org/W1559842180', 'https://openalex.org/W1668774261', 'https://openalex.org/W1907498397', 'https://openalex.org/W1969783034', 'https://openalex.org/W1972686839', 'https://openalex.org/W1977546470', 'https://openalex.org/W1978686705', 'https://openalex.org/W1981335441', 'https://openalex.org/W1984853452', 'https://openalex.org/W1989875191', 'https://openalex.org/W1996822762', 'https://openalex.org/W2007909970', 'https://openalex.org/W2008262149', 'https://openalex.org/W2025336339', 'https://openalex.org/W2025346006', 'https://openalex.org/W2037928475', 'https://openalex.org/W2040735196', 'https://openalex.org/W2050990545', 'https://openalex.org/W2052948419', 'https://openalex.org/W2065108994', 'https://openalex.org/W2065576780', 'https://openalex.org/W2068384448', 'https://openalex.org/W2068903461', 'https://openalex.org/W2071291138', 'https://openalex.org/W2071743575', 'https://openalex.org/W2076593960', 'https://openalex.org/W2078957773', 'https://openalex.org/W2080809922', 'https://openalex.org/W2082919075', 'https://openalex.org/W2113334969', 'https://openalex.org/W2127393421', 'https://openalex.org/W2130207623', 'https://openalex.org/W2142778960', 'https://openalex.org/W2144264664', 'https://openalex.org/W2154029983', 'https://openalex.org/W2164488073', 'https://openalex.org/W2171240903', 'https://openalex.org/W232671765', 'https://openalex.org/W258316223', 'https://openalex.org/W2915190566'], 'related_works': ['https://openalex.org/W4248907925', 'https://openalex.org/W2418652933', 'https://openalex.org/W2188518547', 'https://openalex.org/W2143713452', 'https://openalex.org/W2093020311', 'https://openalex.org/W2083725451', 'https://openalex.org/W2078049856', 'https://openalex.org/W2016112814', 'https://openalex.org/W1605244573', 'https://openalex.org/W1569501086'], 'abstract_inverted_index': {'In': [0, 128], 'murine': [1], 'T': [2, 11], 'cell': [3, 12], 'development,': [4], 'early': [5], 'thymocytes': [6, 75, 93, 225], 'that': [7, 55, 94, 183, 214], 'productively': [8], 'rearrange': [9], 'the': [10, 62, 77, 136, 145, 161, 164, 215, 233, 240], 'receptor': [13], '(TCR)': [14], 'beta': [15, 35, 59, 67, 103, 117, 132, 238], 'locus': [16], 'are': [17], 'selected': [18], 'to': [19, 44, 157, 170, 221], 'continue': [20], 'maturation,': [21], 'before': [22], 'TCR': [23, 34, 58, 66, 78, 90, 102, 110, 116, 124, 131, 138, 151, 194, 218, 222, 237, 251], 'alpha': [24, 167, 186], 'expression,': [25], 'by': [26], 'means': [27], 'of': [28, 40, 64, 89, 177, 206, 236, 246, 250], 'a': [29, 86, 130, 227], 'pre-TCR': [30], 'alpha-': [31], '(pT': [32], 'alpha-)': [33], 'heterodimer': [36, 140], '(pre-TCR).': [37], 'The': [38], 'aim': [39], 'this': [41], 'study': [42], 'was': [43, 106, 119, 141], 'identify': [45, 158], 'equivalent': [46], 'stages': [47, 176, 205], 'in': [48, 72, 85, 98, 109, 121, 190, 201], 'human': [49, 165, 247], 'thymocyte': [50, 178], 'development.': [51, 179, 207], 'We': [52], 'show': [53, 182], 'here': [54], 'variable-diversity-joining': [56], 'region': [57], 'rearrangement': [60], 'and': [61, 82, 159, 169, 192, 203, 243], 'expression': [63, 105, 173, 235], 'full-length': [65], 'transcripts': [68], 'have': [69], 'been': [70], 'initiated': [71], 'some': [73], 'immature': [74], 'at': [76, 174, 231], 'alpha/beta-': [79, 91, 111, 125, 152, 195, 219, 223], 'CD4+CD8-': [80, 112, 191, 220], 'stage,': [81], 'become': [83], 'common': [84], 'downstream': [87], 'subset': [88], 'CD4+CD8+': [92, 126, 153, 193, 224], 'is': [95, 199], 'highly': [96], 'enriched': [97], 'large': [99], 'cycling': [100], 'cells.': [101], 'chain': [104, 118], 'hardly': [107], 'detected': [108], 'thymocytes,': [113, 196, 248], 'whereas': [114, 197], 'cytoplasmic': [115], 'found': [120], 'virtually': [122], 'all': [123], 'blasts.': [127], 'addition,': [129], 'complex': [133], 'distinct': [134], 'from': [135, 144, 150, 217], 'mature': [137], 'alpha/beta': [139], 'immunoprecipitated': [142], 'only': [143, 189], 'latter': [146], 'subset.': [147], 'cDNA': [148], 'derived': [149], 'blasts': [154], 'allowed': [155], 'us': [156], 'clone': [160], 'gene': [162], 'encoding': [163], 'pT': [166, 185], 'chain,': [168], 'examine': [171], 'its': [172], 'different': [175], 'Our': [180], 'results': [181], 'high': [184], 'transcription': [187], 'occurs': [188], 'it': [198], 'weaker': [200], 'earlier': [202], 'later': [204], 'Based': [208], 'on': [209], 'these': [210], 'results,': [211], 'we': [212], 'propose': [213], 'transition': [216], 'represents': [226], 'critical': [228], 'developmental': [229], 'stage': [230], 'which': [232], 'successful': [234], 'promotes': [239], 'clonal': [241], 'expansion': [242], 'further': [244], 'maturation': [245], 'independent': [249], 'alpha.': [252]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1969542161', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-14T07:56:20.598206', 'created_date': '2016-06-24'}