Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1969505923', 'doi': 'https://doi.org/10.1042/bj20030107', 'title': 'cGMP-dependent protein kinase protects cGMP from hydrolysis by phosphodiesterase-5', 'display_name': 'cGMP-dependent protein kinase protects cGMP from hydrolysis by phosphodiesterase-5', 'publication_year': 2003, 'publication_date': '2003-06-01', 'ids': {'openalex': 'https://openalex.org/W1969505923', 'doi': 'https://doi.org/10.1042/bj20030107', 'mag': '1969505923', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12617722', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1223414'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1042/bj20030107', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S44425019', 'display_name': 'Biochemical Journal', 'issn_l': '0264-6021', 'issn': ['0264-6021', '1470-8728'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc1223414?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5005406149', 'display_name': 'Jun Kotera', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jun KOTERA', 'raw_affiliation_strings': ['Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232-0615, U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232-0615, U.S.A.', 'institution_ids': ['https://openalex.org/I200719446']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030710434', 'display_name': 'Kennard Grimes', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kennard A. GRIMES', 'raw_affiliation_strings': ['Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232-0615, U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232-0615, U.S.A.', 'institution_ids': ['https://openalex.org/I200719446']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012382947', 'display_name': 'Jackie D. Corbin', 'orcid': 'https://orcid.org/0000-0003-0122-4324'}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jackie D. CORBIN', 'raw_affiliation_strings': ['Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232-0615, U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232-0615, U.S.A.', 'institution_ids': ['https://openalex.org/I200719446']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5034675601', 'display_name': 'Sharron H. Francis', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200719446', 'display_name': 'Vanderbilt University', 'ror': 'https://ror.org/02vm5rt34', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I200719446']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sharron H. FRANCIS', 'raw_affiliation_strings': ['Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232-0615, U.S.A.'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232-0615, U.S.A.', 'institution_ids': ['https://openalex.org/I200719446']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.747, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 37, 'citation_normalized_percentile': {'value': 0.760772, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '372', 'issue': '2', 'first_page': '419', 'last_page': '426'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12434', 'display_name': 'Molecular Regulation and Clinical Applications of PDEs', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12434', 'display_name': 'Molecular Regulation and Clinical Applications of PDEs', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10155', 'display_name': 'Role of Nitric Oxide in Health and Disease', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12251', 'display_name': 'Catalytic C-H Amination Reactions', 'score': 0.9905, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/phosphodiesterase-3', 'display_name': 'Phosphodiesterase 3', 'score': 0.87005687}, {'id': 'https://openalex.org/keywords/pde10a', 'display_name': 'PDE10A', 'score': 0.73271435}, {'id': 'https://openalex.org/keywords/cgmp-dependent-protein-kinase', 'display_name': 'cGMP-dependent protein kinase', 'score': 0.71378535}, {'id': 'https://openalex.org/keywords/zaprinast', 'display_name': 'Zaprinast', 'score': 0.6830678}, {'id': 'https://openalex.org/keywords/camp-signaling', 'display_name': 'cAMP Signaling', 'score': 0.43561}], 'concepts': [{'id': 'https://openalex.org/C150109051', 'wikidata': 'https://www.wikidata.org/wiki/Q3630494', 'display_name': 'Autophosphorylation', 'level': 4, 'score': 0.8950697}, {'id': 'https://openalex.org/C58141971', 'wikidata': 'https://www.wikidata.org/wiki/Q906688', 'display_name': 'Phosphodiesterase 3', 'level': 4, 'score': 0.87005687}, {'id': 'https://openalex.org/C62826618', 'wikidata': 'https://www.wikidata.org/wiki/Q424304', 'display_name': 'Phosphodiesterase', 'level': 3, 'score': 0.78213704}, {'id': 'https://openalex.org/C79418042', 'wikidata': 'https://www.wikidata.org/wiki/Q5864325', 'display_name': 'PDE10A', 'level': 4, 'score': 0.73271435}, {'id': 'https://openalex.org/C199217515', 'wikidata': 'https://www.wikidata.org/wiki/Q24720987', 'display_name': 'cGMP-dependent protein kinase', 'level': 5, 'score': 0.71378535}, {'id': 'https://openalex.org/C2776846068', 'wikidata': 'https://www.wikidata.org/wiki/Q6592076', 'display_name': 'Zaprinast', 'level': 4, 'score': 0.6830678}, {'id': 'https://openalex.org/C97029542', 'wikidata': 'https://www.wikidata.org/wiki/Q281417', 'display_name': 'Protein kinase A', 'level': 3, 'score': 0.5843309}, {'id': 'https://openalex.org/C74534348', 'wikidata': 'https://www.wikidata.org/wiki/Q410798', 'display_name': 'cGMP-specific phosphodiesterase type 5', 'level': 3, 'score': 0.5163111}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5065099}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.4348925}, {'id': 'https://openalex.org/C184235292', 'wikidata': 'https://www.wikidata.org/wiki/Q421851', 'display_name': 'Kinase', 'level': 2, 'score': 0.3650052}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3078884}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.24079567}, {'id': 'https://openalex.org/C2776768464', 'wikidata': 'https://www.wikidata.org/wiki/Q191521', 'display_name': 'Sildenafil', 'level': 2, 'score': 0.09090865}, {'id': 'https://openalex.org/C90934575', 'wikidata': 'https://www.wikidata.org/wiki/Q6593810', 'display_name': 'Mitogen-activated protein kinase kinase', 'level': 4, 'score': 0.08833301}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.07736325}], 'mesh': [{'descriptor_ui': 'D006152', 'descriptor_name': 'Cyclic GMP', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D017869', 'descriptor_name': 'Cyclic GMP-Dependent Protein Kinases', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D010727', 'descriptor_name': 'Phosphoric Diester Hydrolases', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D015106', 'descriptor_name': "3',5'-Cyclic-GMP Phosphodiesterases", 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000494', 'descriptor_name': 'Allosteric Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001665', 'descriptor_name': 'Binding Sites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002417', 'descriptor_name': 'Cattle', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006152', 'descriptor_name': 'Cyclic GMP', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D062965', 'descriptor_name': 'Cyclic GMP-Dependent Protein Kinase Type I', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017869', 'descriptor_name': 'Cyclic GMP-Dependent Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054706', 'descriptor_name': 'Cyclic Nucleotide Phosphodiesterases, Type 5', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018076', 'descriptor_name': 'DNA, Complementary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018076', 'descriptor_name': 'DNA, Complementary', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019281', 'descriptor_name': 'Dimerization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006868', 'descriptor_name': 'Hydrolysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016297', 'descriptor_name': 'Mutagenesis, Site-Directed', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010727', 'descriptor_name': 'Phosphoric Diester Hydrolases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011994', 'descriptor_name': 'Recombinant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1042/bj20030107', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S44425019', 'display_name': 'Biochemical Journal', 'issn_l': '0264-6021', 'issn': ['0264-6021', '1470-8728'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311608', 'host_organization_name': 'Portland Press', 'host_organization_lineage': ['https://openalex.org/P4310311715', 'https://openalex.org/P4310311608'], 'host_organization_lineage_names': ['Biochemical Society', 'Portland Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1223414', 'pdf_url': 'https://europepmc.org/articles/pmc1223414?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223414', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12617722', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1223414', 'pdf_url': 'https://europepmc.org/articles/pmc1223414?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Responsible consumption and production', 'id': 'https://metadata.un.org/sdg/12', 'score': 0.44}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 44, 'referenced_works': ['https://openalex.org/W141492169', 'https://openalex.org/W1440698795', 'https://openalex.org/W1518970589', 'https://openalex.org/W1524509448', 'https://openalex.org/W1540498597', 'https://openalex.org/W1550626564', 'https://openalex.org/W1560688999', 'https://openalex.org/W1566330131', 'https://openalex.org/W1589398776', 'https://openalex.org/W1589511629', 'https://openalex.org/W1967215398', 'https://openalex.org/W1968017178', 'https://openalex.org/W1969505923', 'https://openalex.org/W1970467732', 'https://openalex.org/W1976752102', 'https://openalex.org/W1981528113', 'https://openalex.org/W1993557397', 'https://openalex.org/W1998143238', 'https://openalex.org/W2015135418', 'https://openalex.org/W2029382982', 'https://openalex.org/W2035348154', 'https://openalex.org/W2041172195', 'https://openalex.org/W2041816586', 'https://openalex.org/W2045150258', 'https://openalex.org/W2047891873', 'https://openalex.org/W2049472065', 'https://openalex.org/W2051852292', 'https://openalex.org/W2058189467', 'https://openalex.org/W2058278329', 'https://openalex.org/W2068117750', 'https://openalex.org/W2085220858', 'https://openalex.org/W2085230960', 'https://openalex.org/W2121486402', 'https://openalex.org/W2128635872', 'https://openalex.org/W2134184057', 'https://openalex.org/W2152187474', 'https://openalex.org/W2258411363', 'https://openalex.org/W2401432192', 'https://openalex.org/W2468444334', 'https://openalex.org/W324436745', 'https://openalex.org/W4249550281', 'https://openalex.org/W4250059425', 'https://openalex.org/W4293247451', 'https://openalex.org/W84724570'], 'related_works': ['https://openalex.org/W2172022460', 'https://openalex.org/W2118969839', 'https://openalex.org/W2091551026', 'https://openalex.org/W2083980443', 'https://openalex.org/W2081040687', 'https://openalex.org/W2030632713', 'https://openalex.org/W2015050915', 'https://openalex.org/W1980514211', 'https://openalex.org/W1969505923', 'https://openalex.org/W1560688999'], 'abstract_inverted_index': {'The': [0, 168], 'physiological': [1, 80], 'effects': [2, 44, 139], 'of': [3, 11, 28, 35, 45, 52, 72, 82, 108, 130, 143, 146, 155, 166, 178, 190], 'cGMP': [4, 29, 53, 66, 98, 103, 156, 172, 191, 205], 'are': [5], 'largely': [6], 'determined': [7], 'by': [8, 55, 113, 120, 157, 184, 192], 'the': [9, 26, 36, 40, 43, 50, 56, 79], 'activities': [10], 'intracellular': [12], 'receptors,': [13], 'including': [14], 'cGMP-dependent': [15], 'protein': [16], 'kinase': [17], '(PKG)': [18], 'and': [19, 25, 136, 186], 'cGMP-binding': [20, 134, 176], 'cyclic': [21], 'nucleotide': [22], 'phosphodiesterases': [23], '(PDEs),': [24], 'distribution': [27], 'among': [30], 'these': [31], 'receptors': [32], 'dictates': [33], 'activity': [34], 'signalling': [37], 'pathway.': [38], 'In': [39], 'present': [41], 'study,': [42], 'PKG-Iα': [46, 63, 114], 'or': [47, 195], 'PKG-Iβ': [48, 147], 'on': [49, 140, 152], 'rate': [51], 'hydrolysis': [54, 67, 104, 142, 154, 183], 'isolated': [57], 'PDE5': [58, 141, 153, 185], 'catalytic': [59], 'domain': [60], 'were': [61], 'examined.': [62], 'strongly': [64], 'inhibited': [65, 102], 'with': [68, 105, 123, 160], 'an': [69, 106], 'IC50': [70, 107], 'value': [71], '217': [73], 'nM,': [74], 'which': [75, 93], 'is': [76, 180], 'similar': [77], 'to': [78, 174, 203], 'concentration': [81], 'PKG': [83, 179], 'in': [84], 'pig': [85], 'coronary': [86], 'artery': [87], 'reported': [88], 'previously.': [89], 'By': [90], 'contrast,': [91], 'PKG-Iβ,': [92, 121], 'has': [94], 'lower': [95], 'affinity': [96], 'for': [97, 127], 'than': [99, 118], 'does': [100], 'PKG-Iα,': [101], 'approx.': [109], '1': [110], 'μM.': [111], 'Inhibition': [112], 'was': [115], 'more': [116], 'effective': [117], 'that': [119, 171, 187], 'consistent': [122], 'their': [124, 133, 137], 'relative': [125], 'affinities': [126, 135], 'cGMP.': [128, 144], 'Autophosphorylation': [129, 145], 'PKGs': [131, 197], 'increased': [132, 148], 'inhibitory': [138, 150], 'its': [149], 'potency': [151], '10-fold': [158], 'compared': [159], 'a': [161, 200], '2-fold': [162], 'increase': [163], 'upon': [164], 'autophosphorylation': [165], 'PKG-Iα.': [167], 'results': [169], 'indicate': [170], 'bound': [173], 'allosteric': [175], 'sites': [177], 'protected': [181], 'from': [182], 'persistent': [188], 'protection': [189], 'either': [193], 'non-phosphorylated': [194], 'autophosphorylated': [196], 'may': [198], 'be': [199], 'positive-feedback': [201], 'control': [202], 'sustain': [204], 'signalling.': [206]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1969505923', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-08-15T03:43:53.214069', 'created_date': '2016-06-24'}