Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1969445695', 'doi': 'https://doi.org/10.1016/j.aquatox.2011.08.022', 'title': 'In vitro inhibition of cytochrome P450-mediated reactions by gemfibrozil, erythromycin, ciprofloxacin and fluoxetine in fish liver microsomes', 'display_name': 'In vitro inhibition of cytochrome P450-mediated reactions by gemfibrozil, erythromycin, ciprofloxacin and fluoxetine in fish liver microsomes', 'publication_year': 2011, 'publication_date': '2011-09-23', 'ids': {'openalex': 'https://openalex.org/W1969445695', 'doi': 'https://doi.org/10.1016/j.aquatox.2011.08.022', 'mag': '1969445695', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22000335'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.aquatox.2011.08.022', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S183233548', 'display_name': 'Aquatic Toxicology', 'issn_l': '0166-445X', 'issn': ['0166-445X', '1879-1514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101941624', 'display_name': 'Emily M. Smith', 'orcid': 'https://orcid.org/0000-0002-5668-2456'}, 'institutions': [{'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Emily M. Smith', 'raw_affiliation_strings': ['Dept. of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1.'], 'affiliations': [{'raw_affiliation_string': 'Dept. of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1.', 'institution_ids': ['https://openalex.org/I98251732']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047630619', 'display_name': 'Fathima I. Iftikar', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Fathima I. Iftikar', 'raw_affiliation_strings': ['Dept. of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1.'], 'affiliations': [{'raw_affiliation_string': 'Dept. of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1.', 'institution_ids': ['https://openalex.org/I98251732']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023385627', 'display_name': 'Sarah Higgins', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Sarah Higgins', 'raw_affiliation_strings': ['Dept. of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1.'], 'affiliations': [{'raw_affiliation_string': 'Dept. of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1.', 'institution_ids': ['https://openalex.org/I98251732']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064391332', 'display_name': 'Anam Irshad', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Anam Irshad', 'raw_affiliation_strings': ['Dept. of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1.'], 'affiliations': [{'raw_affiliation_string': 'Dept. of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1.', 'institution_ids': ['https://openalex.org/I98251732']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085876066', 'display_name': 'Racquel Jandoc', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Racquel Jandoc', 'raw_affiliation_strings': ['Dept. of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1.'], 'affiliations': [{'raw_affiliation_string': 'Dept. of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1.', 'institution_ids': ['https://openalex.org/I98251732']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100376664', 'display_name': 'Matthew Lee', 'orcid': 'https://orcid.org/0000-0003-1824-8525'}, 'institutions': [{'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Matthew Lee', 'raw_affiliation_strings': ['Dept. of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1.'], 'affiliations': [{'raw_affiliation_string': 'Dept. of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1.', 'institution_ids': ['https://openalex.org/I98251732']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5016758271', 'display_name': 'Joanna Y. Wilson', 'orcid': 'https://orcid.org/0000-0003-4245-1304'}, 'institutions': [{'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Joanna Y. Wilson', 'raw_affiliation_strings': ['Dept. of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1.'], 'affiliations': [{'raw_affiliation_string': 'Dept. of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada L8S 4K1.', 'institution_ids': ['https://openalex.org/I98251732']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3460, 'currency': 'USD', 'value_usd': 3460, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.937, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 66, 'citation_normalized_percentile': {'value': 0.899651, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '109', 'issue': None, 'first_page': '259', 'last_page': '266'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10419', 'display_name': 'Pharmaceutical and Antibiotic Environmental Impacts', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2310', 'display_name': 'Pollution'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10419', 'display_name': 'Pharmaceutical and Antibiotic Environmental Impacts', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2310', 'display_name': 'Pollution'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10375', 'display_name': 'Pharmacogenetics and Drug Metabolism', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11036', 'display_name': 'Antibiotics Pharmacokinetics and Efficacy', 'score': 0.9944, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/gemfibrozil', 'display_name': 'Gemfibrozil', 'score': 0.8603068}, {'id': 'https://openalex.org/keywords/microsoma', 'display_name': 'Microsoma', 'score': 0.5105775}], 'concepts': [{'id': 'https://openalex.org/C2778670441', 'wikidata': 'https://www.wikidata.org/wiki/Q384295', 'display_name': 'Gemfibrozil', 'level': 3, 'score': 0.8603068}, {'id': 'https://openalex.org/C526171541', 'wikidata': 'https://www.wikidata.org/wiki/Q407693', 'display_name': 'Cytochrome P450', 'level': 3, 'score': 0.6968834}, {'id': 'https://openalex.org/C87644729', 'wikidata': 'https://www.wikidata.org/wiki/Q547502', 'display_name': 'Microsome', 'level': 3, 'score': 0.6843077}, {'id': 'https://openalex.org/C2780206985', 'wikidata': 'https://www.wikidata.org/wiki/Q213511', 'display_name': 'Erythromycin', 'level': 3, 'score': 0.6453626}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.5995838}, {'id': 'https://openalex.org/C2778512257', 'wikidata': 'https://www.wikidata.org/wiki/Q256602', 'display_name': 'Ciprofloxacin', 'level': 3, 'score': 0.51671124}, {'id': 'https://openalex.org/C2776524530', 'wikidata': 'https://www.wikidata.org/wiki/Q4119721', 'display_name': 'Microsoma', 'level': 4, 'score': 0.5105775}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.49890566}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.49885964}, {'id': 'https://openalex.org/C2776134451', 'wikidata': 'https://www.wikidata.org/wiki/Q422244', 'display_name': 'Fluoxetine', 'level': 4, 'score': 0.47263545}, {'id': 'https://openalex.org/C2909208804', 'wikidata': 'https://www.wikidata.org/wiki/Q127282', 'display_name': 'Fish <Actinopterygii>', 'level': 2, 'score': 0.44087544}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3114193}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.26028627}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.23336479}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.18719754}, {'id': 'https://openalex.org/C505870484', 'wikidata': 'https://www.wikidata.org/wiki/Q180538', 'display_name': 'Fishery', 'level': 1, 'score': 0.14429036}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.07536888}, {'id': 'https://openalex.org/C2778163477', 'wikidata': 'https://www.wikidata.org/wiki/Q43656', 'display_name': 'Cholesterol', 'level': 2, 'score': 0.071689874}, {'id': 'https://openalex.org/C2775864247', 'wikidata': 'https://www.wikidata.org/wiki/Q167934', 'display_name': 'Serotonin', 'level': 3, 'score': 0.060952395}], 'mesh': [{'descriptor_ui': 'D008862', 'descriptor_name': 'Microsomes, Liver', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D017686', 'descriptor_name': 'Oncorhynchus mykiss', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D014874', 'descriptor_name': 'Water Pollutants, Chemical', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002939', 'descriptor_name': 'Ciprofloxacin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002939', 'descriptor_name': 'Ciprofloxacin', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D003577', 'descriptor_name': 'Cytochrome P-450 Enzyme System', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D003577', 'descriptor_name': 'Cytochrome P-450 Enzyme System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004789', 'descriptor_name': 'Enzyme Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004917', 'descriptor_name': 'Erythromycin', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D004917', 'descriptor_name': 'Erythromycin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029941', 'descriptor_name': 'Fish Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D029941', 'descriptor_name': 'Fish Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005473', 'descriptor_name': 'Fluoxetine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005473', 'descriptor_name': 'Fluoxetine', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D015248', 'descriptor_name': 'Gemfibrozil', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015248', 'descriptor_name': 'Gemfibrozil', 'qualifier_ui': 'Q000633', 'qualifier_name': 'toxicity', 'is_major_topic': False}, {'descriptor_ui': 'D008862', 'descriptor_name': 'Microsomes, Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008862', 'descriptor_name': 'Microsomes, Liver', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D017686', 'descriptor_name': 'Oncorhynchus mykiss', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014874', 'descriptor_name': 'Water Pollutants, Chemical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015027', 'descriptor_name': 'Zebrafish', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.aquatox.2011.08.022', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S183233548', 'display_name': 'Aquatic Toxicology', 'issn_l': '0166-445X', 'issn': ['0166-445X', '1879-1514'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22000335', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/14', 'display_name': 'Life below water', 'score': 0.66}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 41, 'referenced_works': ['https://openalex.org/W146498581', 'https://openalex.org/W1605114492', 'https://openalex.org/W1934270266', 'https://openalex.org/W1951469402', 'https://openalex.org/W1957877535', 'https://openalex.org/W1964522544', 'https://openalex.org/W1972816241', 'https://openalex.org/W1974135197', 'https://openalex.org/W1976567887', 'https://openalex.org/W1979610724', 'https://openalex.org/W1986805574', 'https://openalex.org/W1992568187', 'https://openalex.org/W1999289347', 'https://openalex.org/W2009649574', 'https://openalex.org/W2023887872', 'https://openalex.org/W2029445153', 'https://openalex.org/W2029593210', 'https://openalex.org/W2036214382', 'https://openalex.org/W2036582121', 'https://openalex.org/W2037766564', 'https://openalex.org/W2045041505', 'https://openalex.org/W2045371772', 'https://openalex.org/W2045654730', 'https://openalex.org/W2049246694', 'https://openalex.org/W2050511211', 'https://openalex.org/W2053322034', 'https://openalex.org/W2062920994', 'https://openalex.org/W2065568958', 'https://openalex.org/W2067694848', 'https://openalex.org/W2075180687', 'https://openalex.org/W2087413883', 'https://openalex.org/W2091036864', 'https://openalex.org/W2094482270', 'https://openalex.org/W2096565553', 'https://openalex.org/W2126277206', 'https://openalex.org/W2136613655', 'https://openalex.org/W2142366726', 'https://openalex.org/W2151745588', 'https://openalex.org/W2160284634', 'https://openalex.org/W2168484164', 'https://openalex.org/W2341486613'], 'related_works': ['https://openalex.org/W4290117842', 'https://openalex.org/W2997529312', 'https://openalex.org/W294468125', 'https://openalex.org/W2764973524', 'https://openalex.org/W2409961224', 'https://openalex.org/W2394926941', 'https://openalex.org/W2275312961', 'https://openalex.org/W2129682075', 'https://openalex.org/W2061611908', 'https://openalex.org/W2028468709'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1969445695', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 10}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-16T05:21:35.716355', 'created_date': '2016-06-24'}