A New Peptidic Ligand and Its Receptor Regulating Adrenal Function in Rats

Name: Work Video:
Duration: 3 min 30 s
Shoji Fukusumi; Hiromi Yoshida; Ryo Fujii; Minoru Maruyama; Hidetoshi Komatsu; Yugo Habata; Yasushi Shintani; Shuji Hinuma; Masahiko Fujino
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4248], 'human': [12, 158, 338, 392, 688, 1234, 1303, 1351, 1461, 1560, 1591, 1714, 1758, 1851, 2314, 2903, 3042, 3115, 3157, 3404, 3613, 3872, 4052], 'genome': [13, 159, 1235, 2904, 3411], 'data': [14, 160, 1236, 1325, 2905, 4283, 4475], 'base': [15, 161, 1237, 2906], 'and': [16, 42, 62, 86, 98, 134, 162, 188, 208, 232, 244, 280, 299, 363, 452, 732, 981, 1052, 1064, 1071, 1153, 1211, 1238, 1264, 1271, 1314, 1322, 1373, 1408, 1429, 1466, 1493, 1506, 1532, 1544, 1555, 1607, 1637, 1652, 1674, 1681, 1706, 1723, 1726, 1738, 1811, 1903, 1914, 2013, 2021, 2059, 2170, 2360, 2401, 2414, 2420, 2478, 2484, 2490, 2493, 2536, 2546, 2583, 2598, 2638, 2652, 2669, 2673, 2683, 2774, 2791, 2808, 2820, 2930, 2940, 3065, 3212, 3417, 3463, 3482, 3500, 3526, 3536, 3567, 3628, 3675, 3878, 3896, 3997, 3999, 4040, 4054, 4089, 4097, 4186, 4243, 4317, 4405, 4410, 4506], 'identified': [17, 163, 349, 1040, 1240, 1261, 3266], 'new': [19, 165, 387, 1150, 1228], 'gene': [20, 166, 1231, 1906, 1910, 3678, 4155], 'encoding': [21, 167], 'preproprotein': [23, 169, 3089, 3615], 'that': [24, 64, 132, 170, 210, 278, 754, 798, 1057, 1072, 1284, 1700, 3045, 3130, 3143, 3163, 3178, 3263, 3377, 3400, 3533, 3578, 3736, 3855, 4128, 4148, 4172, 4187, 4245, 4320, 4348, 4380, 4440, 4495], 'could': [25, 171, 3893, 3981, 4276], 'generate': [26, 172, 4314], 'peptide.': [28, 55, 174, 201, 3107], 'This': [29, 175, 1383, 2333, 2786, 3681], 'peptide': [30, 176, 675, 678, 703, 759, 791, 884, 925, 1051, 1152, 1230, 1263, 2743, 2899, 2915, 2944, 3050, 3146, 3173, 3268, 3391, 3563, 3594, 3665, 3799, 3815, 3849, 3861, 4206, 4217, 4266, 4300, 4325, 4386, 4438], 'consisted': [31, 177], 'of': [32, 84, 124, 129, 178, 230, 270, 275, 307, 309, 367, 375, 390, 402, 411, 413, 449, 709, 718, 1035, 1049, 1060, 1080, 1148, 1258, 1298, 1343, 1368, 1376, 1420, 1459, 1509, 1549, 1582, 1601, 1610, 1661, 1744, 1756, 1767, 1911, 1956, 1964, 1970, 1976, 1999, 2114, 2312, 2353, 2372, 2388, 2398, 2418, 2428, 2511, 2517, 2531, 2636, 2701, 2735, 2759, 2764, 2812, 2886, 2896, 2947, 3056, 3083, 3169, 3179, 3204, 3208, 3241, 3247, 3284, 3496, 3552, 3600, 3611, 3688, 3739, 3752, 3777, 3783, 3794, 3803, 3813, 3834, 3839, 3844, 3859, 3987, 4038, 4121, 4138, 4164, 4203, 4215, 4264, 4298, 4309, 4384, 4402, 4435, 4441, 4459], '43': [33, 179], 'amino': [34, 180, 3080, 3094, 3166, 3205, 3475, 3493, 3503, 3538, 3597], 'acid': [35, 41, 181, 187, 2001, 3081, 3095, 3167, 3206, 3476, 3494, 3504, 3539, 3598, 4501, 4510], 'residues': [36, 182, 3096], 'starting': [37, 183], 'from': [38, 184, 446, 711, 1291, 1350, 1479, 1536, 1541, 1589, 1736, 2411, 2580, 2594, 2768, 3151, 3403, 3466, 3479, 3606, 3685, 3826, 3917, 4180, 4229, 4279], 'N-terminal': [39, 185, 3099, 3133, 4486, 4497], 'pyroglutamic': [40, 186, 2321, 4272, 4509], 'ending': [43, 189], 'at': [44, 190, 573, 1386, 1396, 1402, 1409, 1621, 1631, 1638, 1646, 1653, 1662, 1668, 1675, 1686, 2037, 2362, 2502, 2522, 2540, 2547, 3097, 3119, 3131, 4082, 4102, 4109, 4132, 4143], 'C-terminal': [45, 191, 3121, 3153, 3165, 3216, 3608, 3620, 3631, 4119, 4288, 4295, 4327], 'arginine-phenylalanine-amide.': [46, 192], 'therefore': [48, 194, 444, 3576], 'named': [49, 195], 'it': [50, 196, 4149, 4196, 4236, 4246], 'QRFP': [51, 85, 102, 125, 133, 197, 231, 248, 271, 279, 1299, 1304, 1472, 1497, 1534, 1751, 1759, 2315, 2378, 2400, 2419, 2488, 2597, 2637, 3186, 3579, 3614, 3873, 3988, 4122, 4182, 4310], 'after': [52, 198, 2730], 'pyroglutamylated': [53, 199, 673], 'arginine-phenylalanine-amide': [54, 200, 321, 570, 674, 676], 'subsequently': [57, 203, 1239, 1485, 4025], 'its': [60, 87, 111, 135, 206, 233, 257, 281, 1154, 1241, 1265, 1431, 1708, 2338, 3200, 3461, 3822, 4230], 'receptor': [61, 88, 112, 136, 207, 234, 258, 282, 312, 672, 1155, 1242, 1266, 3523, 3529, 3564, 3635], 'found': [63, 209, 727, 753, 1225, 3040, 3112, 3252, 3376, 3420, 4244], 'Chinese': [65, 211, 681, 1745], 'hamster': [66, 212, 325, 682], 'ovary': [67, 213, 683], 'cells': [68, 214, 475, 1815, 1889, 1921, 1931, 2058, 2062, 2120, 2169, 2173, 2344, 2355, 3294, 3379, 3671, 3877, 3902, 4049, 4185], 'expressing': [69, 215, 476, 2063, 2166, 2345, 3295, 3380, 3673, 3903, 4051], 'an': [70, 216, 1435, 1683, 1768, 2431, 2927, 3048, 3144, 3561, 3596, 3667, 3747, 4496], 'receptor,': [74, 220], 'AQ27,': [75, 221, 3384], 'specifically': [76, 222, 3387], 'responded': [77, 223, 3388], 'to': [78, 224, 352, 399, 463, 1078, 1215, 1287, 1523, 1557, 2029, 2381, 2391, 2513, 2603, 2681, 2909, 3102, 3192, 3292, 3389, 3421, 3424, 3506, 3559, 3625, 3666, 3788, 3817, 3828, 3911, 4005, 4066, 4081, 4160, 4223, 4267, 4313, 4356, 4424, 4427, 4508], 'QRFP.': [79, 225, 3213], 'analyzed': [81, 227, 2425, 4235], 'tissue': [82, 228, 1273], 'distributions': [83, 229], 'mRNAs': [89, 235, 2403, 2422, 2640], 'in': [90, 99, 107, 117, 141, 236, 245, 253, 263, 287, 297, 336, 360, 364, 474, 561, 766, 1069, 1277, 1295, 1330, 1336, 1569, 1575, 1772, 1967, 2018, 2053, 2118, 2222, 2715, 2816, 2901, 3113, 3155, 3253, 3487, 3617, 3749, 3780, 3875, 3887, 3905, 4045, 4061, 4076, 4091, 4207, 4218, 4335, 4465], 'rats': [91, 237, 2563, 2661, 2712, 2813], 'quantitative': [93, 239], 'reverse': [94, 240, 679, 1307], 'transcription-polymerase': [95, 241], 'chain': [96, 242], 'reaction': [97, 243, 1332, 1571, 1685, 2510], 'situ': [100, 246, 1278], 'hybridization.': [101, 247, 1279], 'mRNA': [103, 113, 249, 259, 2489], 'was': [104, 114, 250, 260, 706, 1328, 1384, 1475, 1567, 1619, 1761, 1805, 1855, 1944, 1984, 2008, 2121, 2323, 2379, 2395, 2500, 2641, 2694, 2744, 2766, 2783, 2787, 3123, 3134, 3683, 3850, 3995, 4003, 4010, 4024, 4043, 4141, 4175, 4190, 4221, 4290], 'highly': [105, 115, 251, 261], 'expressed': [106, 116, 252, 262, 3870], 'the': [108, 118, 127, 142, 254, 264, 273, 288, 293, 305, 337, 343, 365, 373, 383, 391, 403, 409, 447, 707, 722, 729, 767, 1047, 1081, 1146, 1226, 1255, 1292, 1318, 1344, 1381, 1457, 1460, 1525, 1583, 1615, 1713, 1757, 1764, 1773, 1850, 1859, 1899, 1919, 1929, 1957, 1962, 1968, 2019, 2030, 2038, 2370, 2382, 2386, 2392, 2509, 2515, 2529, 2554, 2573, 2581, 2604, 2690, 2697, 2726, 2731, 2742, 2747, 2752, 2756, 2760, 2772, 2817, 2897, 2902, 2948, 3014, 3054, 3057, 3098, 3104, 3114, 3120, 3126, 3132, 3152, 3156, 3164, 3170, 3248, 3381, 3510, 3545, 3607, 3612, 3686, 3737, 3750, 3753, 3775, 3781, 3792, 3798, 3801, 3810, 3841, 3845, 3860, 3871, 3888, 3906, 3913, 3918, 3984, 4000, 4006, 4062, 4105, 4118, 4136, 4153, 4181, 4201, 4204, 4213, 4216, 4262, 4265, 4280, 4287, 4294, 4299, 4302, 4321, 4336, 4381, 4403, 4414, 4428, 4436, 4442, 4454, 4472, 4479, 4485], 'hypothalamus,': [109, 255, 1546], 'whereas': [110, 256], 'adrenal': [119, 144, 265, 290, 1293, 2584, 2803], 'gland.': [120, 145, 266, 291], 'The': [121, 267, 698, 1565, 1617, 1800, 2112, 2350, 2474, 2710, 2728, 3074, 3117, 3474, 3990, 4022, 4306, 4395], 'intravenous': [122, 268, 2757], 'administration': [123, 269], 'caused': [126, 272], 'release': [128, 274], 'aldosterone,': [130, 276], 'suggesting': [131, 277], 'have': [137, 283, 303, 345, 456, 725, 793, 1038, 1055, 1065, 1223, 3279], 'regulatory': [139, 285, 388], 'function': [140, 286, 1286, 3271], 'rat': [143, 289, 1471, 1480, 1496, 1526, 1725, 1737, 2412, 2487, 2496, 2596, 2703, 2770, 3462], 'In': [292, 787, 1218, 1280, 1519, 1895, 2307, 2556, 3087, 3159, 4117, 4152], 'last': [294], 'decade,': [295], 'advances': [296], 'cDNA': [298, 1305, 1348, 1359, 1462, 1473, 1491, 1498, 1510, 1515, 1527, 1535, 1562, 1587, 1594, 1715, 1729, 1760, 1853, 3484, 3874, 4307], 'genomic': [300, 3043], 'DNA': [301, 1370, 1439, 2534], 'sequencing': [302], 'revealed': [304], 'existence': [306], 'hundreds': [308], '(GPCR)': [313], '1The': [314], 'abbreviations': [315], 'used': [316, 1891, 2688, 3925], 'are:': [317], 'GPCRG': [318], 'receptorQRFPpyroglutamylated': [320], 'peptideRF-amidearginine-phenylalanine-amideRFRPRFamide-related': [322], 'peptideRTreverse': [323], 'transcriptionCHOChinese': [324], 'ovaryFLIPRfluorometric': [326], 'imaging': [327, 685, 2234], 'plate': [328, 686, 2235], 'readerHEKhuman': [329], 'embryonic': [330, 689], 'kidneyMALDI-TOFmatrix-assisted-laser': [331], 'desorption/ionization': [332, 692, 1979], 'time-of-flightACTHadrenocorticotropic': [333], 'hormoneTAMRA5-carboxytetramethylrhodamineFAM5-carboxyfluorescein.': [334], 'genes': [335, 760, 792], 'genome.': [339], 'Those': [340], 'which': [342, 3513, 4079], 'not': [346, 2336, 2348, 3188, 3393, 3807, 3831, 4191, 4277, 4286, 4340, 4477], 'yet': [347], 'been': [348, 726, 752, 796, 1039, 3419, 3557, 4345], 'are': [350, 397, 733, 1075, 3219, 3485, 3515, 3622], 'referred': [351], 'as': [353, 395, 1818, 1892, 1961, 2070, 2123, 2176, 2248, 2437, 2826, 2926, 2935, 2950, 3256, 3272, 3426, 3542, 3582, 3774, 3800, 4210, 4488], 'GPCRs.': [355], 'GPCRs': [356, 380, 396, 415, 468, 478, 1245, 3287, 3297, 3511, 3740], 'play': [357], 'pivotal': [358], 'roles': [359], 'cell-to-cell': [361], 'communication': [362], 'regulation': [366], 'cell': [368, 2164], 'functions.': [369], 'For': [370], 'this': [371, 557, 1259, 1490, 3037, 3264, 3605, 3663, 3814, 4255, 4385], 'reason,': [372], 'identification': [374, 410, 1048, 1147], 'endogenous': [376], 'will': [381, 416], 'open': [382], 'door': [384], 'clarifying': [386], 'mechanisms': [389], 'body.': [393], 'Furthermore,': [394], 'considered': [398], 'be': [400, 1216, 2042, 3149, 3422, 3560, 3818, 4224, 4268, 4425], 'some': [401], 'most': [404], 'important': [405, 445], 'drug': [406], 'target': [407], 'molecules,': [408], 'provide': [417], 'opportunities': [418], 'developing': [420], 'novel': [421, 3398], 'drugs': [422], '(1Hinuma': [423], 'S.': [424, 480, 490, 533, 535, 578, 588, 617, 621, 815, 862, 886, 896, 928, 932, 988, 998, 1016, 1120, 1181, 1778, 1822, 1866, 2074, 2084, 2127, 2131, 2139, 2186, 2194, 2198, 2286, 2445, 2451, 2620, 2864, 2988, 3023, 3299, 3309, 3352, 3354, 3649, 3695, 3937, 3951], 'Onda': [425, 505, 540, 603, 650, 911, 961, 1019, 1787, 1831, 1875, 2099, 2199, 2452, 3324, 3359, 3958], 'H.': [426, 498, 506, 541, 596, 604, 651, 904, 912, 962, 990, 1020, 1784, 1788, 1828, 1832, 1872, 1876, 2092, 2100, 2133, 2190, 2200, 2453, 2618, 3021, 3317, 3325, 3360, 3639, 3941, 3959], 'Fujino': [427, 507, 542, 605, 658, 913, 969, 1023, 2101, 2142, 2203, 2456, 3326, 3361, 3966], 'M.': [428, 488, 500, 508, 521, 543, 586, 598, 606, 627, 645, 655, 659, 894, 906, 914, 938, 956, 966, 970, 1008, 1012, 1024, 1165, 1171, 1183, 1780, 1824, 1868, 2082, 2094, 2102, 2137, 2143, 2180, 2204, 2443, 2457, 2612, 3307, 3319, 3327, 3340, 3362, 3643, 3705, 3947, 3957, 3963, 3967], 'J.': [429, 809, 867, 1125, 1175, 1185, 1191, 2135, 2205, 2291, 2458, 2869, 2993], 'Mol.': [430], 'Med.': [431], '1999;': [432, 779, 3028], '77:': [433], '495-504Crossref': [434], 'PubMed': [435, 513, 551, 611, 745, 782, 878, 919, 1029, 1136, 1202, 1795, 1839, 1883, 2107, 2151, 2216, 2302, 2469, 2630, 2880, 3004, 3031, 3332, 3370, 3454, 3656, 3711, 3729, 3974, 4369], 'Scopus': [436, 514, 552, 612, 666, 746, 783, 823, 879, 920, 977, 1030, 1137, 1203, 1796, 1840, 1884, 2108, 2152, 2217, 2303, 2470, 2631, 2881, 3005, 3032, 3333, 3371, 3455, 3657, 3712, 3730, 3975, 4370], '(54)': [437], 'Google': [438, 516, 554, 614, 668, 748, 785, 825, 881, 922, 979, 1032, 1139, 1205, 1798, 1842, 1886, 2110, 2154, 2219, 2305, 2472, 2633, 2883, 3007, 3034, 3335, 3373, 3457, 3659, 3714, 3732, 3977, 4372], 'Scholar).': [439, 555, 669, 749, 786, 1033, 1140, 1206, 1799, 1843, 1887, 2111, 2155, 2220, 2306, 2473, 2634, 2884, 3008, 3035, 3374, 3458, 3574, 3660, 3733, 4373], 'Orphan': [440], 'GPCR': [441, 565, 1043, 2051, 3399], 'research': [442], 'is': [443, 799, 2922, 3396, 3534, 4124, 4351, 4492, 4503], 'aspects': [448], 'both': [450, 4157, 4445], 'basic': [451], 'applied': [453, 4004, 4065], 'science.': [454], 'previously': [457, 1249, 1820, 2072, 2125, 2250, 2608, 2828, 2952, 3251, 3280], 'established': [458, 1250, 2060, 4347], 'widely': [460], 'applicable': [461], 'method': [462, 558, 2606, 3687, 3760], 'identify': [464], 'through': [469, 1041, 1276, 2771, 4027], 'monitoring': [470], 'specific': [471, 3895], 'signal': [472, 2943, 3106], 'transductions': [473], '(2Hinuma': [479, 577, 885, 2073, 3298], 'Habata': [481, 522, 579, 642, 887, 953, 2075, 2195, 2448, 3300, 3341, 3640, 3938], 'Y.': [482, 486, 494, 523, 531, 580, 584, 592, 619, 625, 635, 641, 643, 657, 888, 892, 900, 930, 936, 946, 952, 954, 968, 986, 996, 1000, 1002, 1004, 1157, 1786, 1830, 1874, 2076, 2080, 2088, 2184, 2192, 2196, 2447, 2449, 3301, 3305, 3313, 3342, 3350, 3641, 3645, 3693, 3939, 3945, 3955, 3965], 'Fujii': [483, 524, 581, 628, 889, 939, 2077, 2187, 3302, 3343, 3948], 'R.': [484, 525, 582, 629, 811, 890, 940, 2078, 2188, 2441, 3303, 3344, 3436, 3703, 3949], 'Kawamata': [485, 530, 583, 640, 891, 951, 2079, 2183, 2446, 3304, 3349, 3644, 3944], 'Hosoya': [487, 520, 585, 626, 893, 937, 1779, 1823, 1867, 2081, 2442, 3306, 3339, 3642, 3946], 'Fukusumi': [489, 532, 587, 620, 895, 931, 2083, 2193, 2444, 3308, 3351], 'Kitada': [491, 536, 589, 646, 897, 957, 1013, 2085, 2128, 2621, 3310, 3355, 3646, 3952], 'C.': [492, 537, 590, 647, 772, 898, 958, 1014, 2086, 2129, 2622, 3311, 3356, 3647, 3953], 'Masuo': [493, 591, 899, 2087, 3312], 'Asano': [495, 593, 901, 2089, 3314], 'T.': [496, 502, 527, 539, 594, 600, 631, 637, 639, 649, 902, 908, 942, 948, 950, 960, 984, 1006, 1010, 1018, 2090, 2096, 2182, 2616, 3315, 3321, 3346, 3358, 3432, 3442], 'Matsumoto': [497, 595, 624, 903, 935, 989, 2091, 2617, 3316], 'Sekiguchi': [499, 597, 905, 2093, 3318], 'Kurokawa': [501, 538, 599, 648, 907, 959, 1017, 2095, 3320, 3357], 'Nishimura': [503, 601, 652, 909, 963, 1021, 2097, 2201, 2454, 3322, 3960], 'O.': [504, 602, 653, 910, 964, 1022, 2098, 2202, 2455, 3323, 3440, 3961], 'Nature.': [509, 607, 915, 1025, 2103, 3328], '1998;': [510, 548, 608, 916, 2104, 3329, 3367], '393:': [511, 609, 917, 2105, 3330], '272-276Crossref': [512, 610, 918, 2106, 3331], '(541)': [515, 613, 921, 2109, 3334], 'Scholar,': [517, 615, 826, 3336, 3715], '3Tatemoto': [518, 3337], 'K.': [519, 633, 774, 944, 994, 1782, 1826, 1870, 2141, 2610, 2614, 2624, 3338], 'Kakegawa': [526, 3345], 'Zou': [528, 3347], 'M.X.': [529, 3348], 'Hinuma': [534, 2138, 2197, 2450, 2619, 3353, 3648, 3950], 'Biochem.': [544, 2144, 3363, 3707, 3725], 'Biophys.': [545, 1790, 1834, 1878, 2145, 3364, 3651, 3969], 'Res.': [546, 778, 2146, 3365], 'Commun.': [547, 2147, 3366], '251:': [549, 3368], '471-476Crossref': [550, 3369], '(1363)': [553, 3372], 'Through': [556], 'we': [559, 1054, 1222, 1253, 1282, 1310, 1529, 1719, 3039, 3060, 3141, 3161, 3261, 3401, 3590, 3790, 3853, 3869, 3892, 3909, 3924, 4146, 4170, 4234, 4260, 4275, 4292, 4318], 'succeeded': [560], 'identifying': [562], 'various': [563, 1721, 2050, 3285], 'including': [567, 1267], 'peptides': [568, 720, 736, 765, 1062, 1074, 3197, 3211, 3250, 3291, 3632, 4355, 4379], 'with': [569, 704, 721, 1434, 1467, 1499, 1696, 1730, 1849, 1922, 1934, 1946, 1996, 2010, 2025, 2049, 2231, 2325, 2358, 2569, 2588, 2643, 2667, 2739, 2778, 3013, 3068, 3079, 3215, 3520, 3595, 3669, 3742, 3797, 3821, 3983, 4012, 4033, 4047, 4114, 4257, 4326, 4358, 4377], '(RFamide)': [571], 'structure': [572, 724, 3218, 4202, 4263, 4297, 4350, 4487], 'their': [574, 1036, 1208, 1268, 2415, 2821, 3467, 3759, 4359], 'C': [575], 'termini': [576], '4Hinuma': [616], 'Shintani': [618, 929, 985, 2191, 3954], 'Iijima': [622, 933, 3942], 'N.': [623, 934, 1167, 3943], 'Watanabe': [630, 941, 1005], 'Kikuchi': [632, 943], 'Terao': [634, 945, 995], 'Yano': [636, 947], 'Yamamoto': [638, 949], 'Asada': [644, 955, 1007], 'Tanaka': [654, 965, 1783, 1827, 1871, 3962], 'Ibata': [656, 967, 3964], 'Nat.': [660, 971], 'Cell': [661, 972], 'Biol.': [662, 868, 973, 1126, 1192, 2206, 2292, 2459, 2870, 2994], '2000;': [663, 870, 974, 1128, 2208, 2294, 2461, 2872, 2996, 3708], '10:': [664, 975], '703-708Crossref': [665, 976], '(508)': [667, 978], 'RFamide-related': [677, 924], 'transcription': [680, 1308, 3751], 'fluorometric': [684, 2233], 'reader': [687, 2236], 'kidney': [690], 'matrix-assisted-laser': [691], 'time-of-flight': [693, 1980], 'adrenocorticotropic': [694], 'hormone': [695, 1289], '5-carboxytetramethylrhodamine': [696], '5-carboxyfluorescein.': [697], 'first': [699], 'report': [700, 1254], 'on': [701, 1046, 1317, 1456, 1489, 1712, 2002, 2342, 2679, 3137, 3409, 3900], 'RFamide': [705, 735, 758, 790, 1061, 1073, 1151, 1229, 1262, 2889, 2898, 2914, 3049, 3145, 3172, 3196, 3201, 3210, 3217, 3249, 3267, 3562, 3618, 4296, 4315, 4328, 4349, 4354, 4481], 'isolation': [708], 'FMRFamide': [710], 'bivalve': [712], 'mollusks.': [713], 'Since': [714, 4135, 4212], 'then,': [715], 'number': [717, 3415], 'bioactive': [719], 'same': [723, 1227, 2818], 'throughout': [728], 'animal': [730], 'kingdom': [731], 'called': [734], '(5Price': [737], 'D.A.': [738, 852, 1110, 2276, 2854, 2978], 'Greenberg': [739], 'M.J.': [740], 'Science.': [741], '1977;': [742], '197:': [743], '670-671Crossref': [744], '(920)': [747], 'It': [750, 4343, 4491], 'has': [751, 1143, 3418, 3556, 4344], 'more': [755, 3881], 'than': [756, 4226, 4439], '20': [757, 1406], 'encode': [761], 'over': [762, 2519], '50': [763, 2503], 'distinctive': [764], 'nematode': [768], 'Caenorhabditis': [769], 'elegans': [770], '(6Li': [771], 'Kim': [773], 'Nelson': [775], 'L.S.': [776], 'Brain': [777], '848:': [780], '26-34Crossref': [781], '(181)': [784, 3731], 'mammals,': [788], 'four': [789], 'so': [794, 3765], 'far': [795], 'identified,': [797], 'neuropeptide': [800, 1082, 3225, 3228, 3531], 'FF': [801], '(7Perry': [802], 'S.J.': [803], 'Yi-Kung': [804], 'H.E.': [805], 'Cronk': [806], 'D.': [807, 1163], 'Bagust': [808], 'Sharma': [810], 'Walker': [812], 'R.J.': [813], 'Wilson': [814, 861, 1119, 2285, 2863, 2987], 'Burke': [816], 'J.F.': [817, 3444], 'FEBS': [818], 'Lett.': [819, 2626], '1997;': [820, 2148], '409:': [821], '420-430Crossref': [822], '(197)': [824], '8Elshourbagy': [827], 'N.A.': [828, 840, 1086, 1098, 2252, 2264, 2830, 2842, 2954, 2966], 'Ames': [829, 1087, 2253, 2831, 2955], 'R.S.': [830, 1088, 2254, 2832, 2956], 'Fitzgerald': [831, 1089, 2255, 2833, 2957], 'L.R.': [832, 1090, 2256, 2834, 2958], 'Foley': [833, 1091, 2257, 2835, 2959], 'J.J.': [834, 1092, 2258, 2836, 2960], 'Chambers': [835, 1093, 2259, 2837, 2961], 'J.K.': [836, 1094, 2260, 2838, 2962], 'Szekeres': [837, 1095, 2261, 2839, 2963], 'P.G.': [838, 1096, 2262, 2840, 2964], 'Evans': [839, 1097, 2263, 2841, 2965, 3443], 'Schmidt': [841, 1099, 2265, 2843, 2967], 'D.B.': [842, 1100, 2266, 2844, 2968], 'Buckley': [843, 1101, 2267, 2845, 2969], 'P.T.': [844, 1102, 2268, 2846, 2970], 'Dytko': [845, 1103, 2269, 2847, 2971], 'G.M.': [846, 1104, 2270, 2848, 2972], 'Murdock': [847, 1105, 2271, 2849, 2973], 'P.R.': [848, 1106, 2272, 2850, 2974], 'Milligan': [849, 1107, 2273, 2851, 2975], 'G.': [850, 1108, 1169, 2274, 2852, 2976], 'Groarke': [851, 1109, 2275, 2853, 2977], 'Tan': [853, 1111, 2277, 2855, 2979], 'K.B.': [854, 1112, 2278, 2856, 2980], 'Shabon': [855, 1113, 2279, 2857, 2981], 'U.': [856, 1114, 2280, 2858, 2982], 'Nuthulaganti': [857, 1115, 2281, 2859, 2983], 'P.': [858, 1116, 1177, 2282, 2860, 2984], 'Wang': [859, 1117, 1178, 1180, 2283, 2861, 2985], 'D.Y.': [860, 1118, 2284, 2862, 2986], 'Bergsma': [863, 1121, 2287, 2865, 2989], 'D.J.': [864, 1122, 2288, 2866, 2990, 4362], 'Sarau': [865, 1123, 2289, 2867, 2991], 'H.M.': [866, 1124, 2290, 2868, 2992], 'Chem.': [869, 1127, 1193, 2207, 2293, 2460, 2871, 2995], '275:': [871, 1129, 2209, 2295, 2462, 2873, 2997, 3452], '25965-25971Abstract': [872, 1130, 2296, 2874, 2998], 'Full': [873, 875, 1131, 1133, 1197, 1199, 2211, 2213, 2297, 2299, 2464, 2466, 2875, 2877, 2999, 3001], 'Text': [874, 876, 1132, 1134, 1198, 1200, 2212, 2214, 2298, 2300, 2465, 2467, 2876, 2878, 3000, 3002], 'PDF': [877, 1135, 1201, 2215, 2301, 2468, 2879, 3003], '(237)': [880, 1138, 2304, 2882, 3006], 'Scholar),': [882, 923, 980], 'prolactin-releasing': [883, 1050, 3222], '(RFRP)': [926], '(4Hinuma': [927], 'metastin': [982], '(9Ohtaki': [983], 'Honda': [987], 'Hori': [991], 'A.': [992, 3569, 3701], 'Kanehashi': [993], 'Kumano': [997], 'Takatsu': [999], 'Masuda': [1001], 'Ishibashi': [1003], 'Yamada': [1009], 'Suenaga': [1011, 3956], 'Usuki': [1015], '2001;': [1026, 3451, 3971], '411:': [1027], '613-617Crossref': [1028], '(1195)': [1031], 'All': [1034], 'research.': [1044], 'Based': [1045, 1711, 3136], 'RFRP,': [1053], 'proposed': [1056], 'variety': [1059], 'exist': [1063], 'physiological': [1066], 'functions': [1067], 'even': [1068, 3629], 'mammals': [1070, 3254], 'evolutionally': [1076], 'related': [1077], 'members': [1079, 2895], 'Y': [1083], 'family': [1084, 2900], '(8Elshourbagy': [1085, 2251, 2829, 2953], 'Another': [1141], 'group': [1142], 'recently': [1144, 3427], 'reported': [1145, 2951, 3428], '(10Jiang': [1156], 'Luo': [1158], 'L.': [1159, 1179], 'Gustafson': [1160], 'E.L.': [1161], 'Yadav': [1162], 'Laverty': [1164], 'Murgolo': [1166], 'Vassileva': [1168], 'Zeng': [1170], 'Laz': [1172], 'T.M.': [1173], 'Behan': [1174], 'Qiu': [1176], 'Bayne': [1182], 'Greene': [1184], 'Monsma': [1186], 'Jr.,': [1187, 4512], 'F.': [1188], 'Zhang': [1189], 'F.L.': [1190], '2003;': [1194, 2627, 3653], '278:': [1195], '27652-27657Abstract': [1196], '(148)': [1204], 'However,': [1207, 3185, 3809], 'precise': [1209, 1272], 'molecular': [1210, 1256, 4250], 'functional': [1212], 'characterizations': [1213], 'remain': [1214], 'elucidated.': [1217], 'our': [1219, 1248, 3768], 'present': [1220], 'research,': [1221], 'independently': [1224], 'among': [1243, 3125], 'by': [1246, 1306, 1380, 1393, 1477, 1504, 1563, 1614, 1628, 1734, 1857, 2227, 2330, 2404, 2426, 2798, 2924, 2931, 3072, 3288, 3472, 3544, 3767, 4237, 4301], 'applying': [1247], 'method.': [1251], 'Here': [1252], 'characterization': [1257], 'newly': [1260, 3265], 'binding': [1269, 2243, 3636], 'properties': [1270], 'distribution': [1274], 'determined': [1275, 1430, 1707, 2122, 2797, 3543, 4200, 4293, 4484], 'addition,': [1281, 3160], 'demonstrate': [1283], 'they': [1285, 2719], 'regulate': [1288], 'secretion': [1290], 'gland': [1294, 2804], 'rats.': [1296], 'Cloning': [1297, 1548], 'cDNA—To': [1300], 'isolate': [1301, 1558], '(RT)-PCR,': [1309], 'designed': [1311, 1552], 'primers': [1312, 1453, 1487, 1553, 1722], '(5′-ATGGTAAGGCCTTACCCCCTGATCTAC-3′': [1313], '5′-CAAATCCTTCCAAGGCGTCCTGGCCCT-3′)': [1315], 'based': [1316, 1488, 3408], 'Celera': [1319, 1323], 'Discovery': [1320], 'Systems': [1321], 'Genomics-associated': [1324], 'base.': [1326], 'PCR': [1327, 1418, 1566, 1735, 2499, 2520], 'performed': [1329, 1568, 1985, 2009, 2501, 2788], 'mixture': [1333, 1572, 1605, 1618], '(25': [1334, 1573, 2685], 'μl': [1335, 1375, 1574, 1609, 2734, 2763], 'total)': [1337, 1576], 'containing': [1338, 1424, 1577, 4018], '0.2': [1340, 1579, 1596, 4013], 'μm': [1341, 1580, 2376], 'concentration': [1342, 1581], 'primers,': [1345, 1469, 1584], 'template': [1347, 1586, 2600], 'synthesized': [1349, 1455, 1486, 1588, 1720, 2593, 3591], 'brain': [1352, 1481, 1543, 1593, 1740, 3405, 3469], 'poly(A)+': [1353, 1482, 1537, 3406, 3470], 'RNA': [1354, 1538, 2407, 2591, 3407, 3471], '(Clontech)': [1355], 'using': [1356, 1441, 1512, 1986, 2160, 2331, 2430, 2648, 2907, 3929, 4468], 'Marathon': [1358, 1514], 'amplification': [1360, 1508, 1516, 2516], 'kit': [1361, 1446, 1517, 1951], '(Clontech),': [1362, 1372, 1595, 1606], '0.1': [1363], 'mm': [1364, 1597], 'dNTPs,': [1365, 1598], '1.25': [1366, 1599], 'units': [1367, 1600], 'KlenTaq': [1369], 'polymerase': [1371, 1604], '2.5': [1374, 1608], 'buffer': [1378, 1612], 'provided': [1379, 1613, 2666], 'manufacturer.': [1382, 1616], 'conducted': [1385, 2175, 2246, 2642, 4011], '94': [1387], '°C': [1388, 1398, 1404, 1411, 1623, 1633, 1640, 1648, 1655, 1664, 1670, 1677, 1688, 2504, 2524, 2542, 2549], '2': [1390, 1603, 2526, 4090, 4098, 4140, 4189], 'min': [1391, 1626, 2507, 2527], 'followed': [1392, 1627, 2923], '40': [1394, 2538], 'cycles': [1395, 1630, 1645, 1660, 2539], '98': [1397], '10': [1400, 2506, 2733], 's,': [1401, 1407, 1667, 1673], '63': [1403], '72': [1410, 1639], '60': [1413], 's.': [1414], 'obtained': [1416, 1693, 2017], 'product': [1419, 1695, 4178], 'about': [1421, 1697], '300': [1422], 'bp': [1423, 1699], 'full': [1426, 1501, 1703, 1731, 3069, 3864], 'coding': [1427, 1502, 1704, 1732, 1754, 1861, 3070], 'region': [1428, 1503, 1705, 1755, 1766, 1862, 4120], 'nucleotide': [1432, 1709], 'sequence': [1433, 1445, 1463, 1716, 2435, 2945, 3044, 3139, 3168, 4308], 'ABI': [1436, 2432], 'Prism': [1437, 2433], '377': [1438], 'sequencer': [1440], 'dideoxyterminator': [1443], 'cycle': [1444], '(PE': [1447, 1990], 'Biosystems,': [1448], 'Foster': [1449], 'City,': [1450], 'CA).': [1451], 'Various': [1452], 'were': [1454, 1816, 1890, 1916, 1932, 1959, 1994, 2016, 2068, 2174, 2229, 2245, 2356, 2409, 2423, 2480, 2567, 2586, 2665, 2713, 2720, 2796, 2814, 2824, 3011, 3100, 3111, 3772, 3885, 4064, 4074, 4408, 4452], 'basis': [1458, 3055], 'thus': [1464, 1717], 'obtained,': [1465, 1718], 'these': [1468, 2033, 3138, 4168], 'fragment': [1474], 'isolated': [1476, 1495, 1530, 1724, 3061, 3075, 3402, 3460], 'RT-PCR': [1478, 2429], 'RNA.': [1483], 'sequence,': [1492, 3090], 'then': [1494, 1812], '5′-': [1505], '3′-rapid': [1507], 'ends': [1511], '(Clontech).': [1518], 'manner': [1521], 'similar': [1522], 'obtaining': [1524], 'fragment,': [1528], 'mouse': [1531, 1542, 1727, 1739, 3066, 3464, 3483], 'bovine': [1533, 1545], 'fractions': [1539, 2352, 2394, 2408, 4060], 'prepared': [1540, 2069, 2410, 2579], 'respectively.': [1547, 1742, 4412], 'AQ27': [1550, 1561, 1728, 1852, 1860, 1900, 2167, 2346, 2402, 2421, 2497, 2599, 2639, 3395, 3517, 3674, 3786, 3795, 3904, 3916, 4053], 'cDNAs—We': [1551], '(5′-TGTCAGCATGCAGGCGCTTAACATTACCCCGGAGCAG-3′': [1554], '5′-GACTAGTTTAATGCCCACTGTCTAAAGGAGAATTCTC-3′)': [1556], 'RT-PCR.': [1564, 3073, 3473], 'fetal': [1592], 'Advantage': [1602], 'heated': [1620], '95': [1622, 1632, 1647, 1663, 2523, 2541], '1': [1625, 2375, 4088, 4096, 4174, 4209, 4220, 4227], '5': [1629, 1644], '30': [1635, 1650, 1659, 1666, 1672, 3535], 's': [1636, 1651, 2545, 2552], '4': [1642, 1657, 1679, 1938], 'min,': [1643, 1658, 1680], '70': [1654], '68': [1669, 1687], '66': [1676], 'finally': [1682], 'extension': [1684], '3': [1690, 2723], 'min.': [1691, 2367], '1600': [1698], 'contained': [1701, 4150], 'sequence.': [1710], 'regions': [1733, 3071], 'cDNA,': [1741], 'Preparation': [1743], 'Hamster': [1746], 'Ovary': [1747], '(CHO)': [1748], 'Cells': [1749], 'Expressing': [1750], 'cDNA—The': [1752], 'entire': [1753], 'cloned': [1762], 'into': [1763, 1807, 1863, 1918, 2055, 2696, 2746], 'downstream': [1765], 'SR': [1769], 'α': [1770], 'promoter': [1771], 'expression': [1774, 1802, 1847, 1897, 1901, 2047, 2416], 'vector': [1775, 1803, 1848, 1902], 'pAKKO-111H': [1776, 1864, 2054], '(11Hinuma': [1777, 1821, 1865], 'Ogi': [1781, 1825, 1869], 'Nagai': [1785, 1829, 1873], 'Biochim.': [1789, 1833, 1877, 3650, 3968], 'Acta.': [1791, 1835, 1879, 3652, 3970], '1994;': [1792, 1836, 1880, 4366], '1219:': [1793, 1837, 1881], '251-259Crossref': [1794, 1838, 1882], '(36)': [1797, 1841, 1885], 'resultant': [1801], 'plasmid': [1804], 'transfected': [1806, 1930, 2046], 'dhfr–': [1808, 2056], 'CHO': [1809, 1814, 2057, 2061, 2119, 2163, 2172, 2343, 3293, 3378, 3876, 4184], 'cells,': [1810], 'dhfr+': [1813], 'selected': [1817], 'described': [1819, 2071, 2124, 2177, 2249, 2438, 2607, 2827], 'Reporter': [1844], 'Gene': [1845, 3449], 'Assays—An': [1846], '(pAKKO-hAQ27)': [1854], 'constructed': [1856], 'inserting': [1858], 'HEK293': [1888, 3670, 3901, 4048], 'host': [1893, 1920], 'cells.': [1894], 'transient': [1896], 'assays,': [1898], 'reporter': [1905, 3677, 4056, 4154, 4337], '(i.e.': [1907, 2316, 2806, 2916, 3051, 3174, 3181, 4086], 'fusion': [1909], 'cAMP-responsive': [1912, 3754], 'element': [1913, 3755], 'luciferase)': [1915], 'co-transfected': [1917], 'LipofectAMINE': [1923], '2000': [1924], '(Invitrogen).': [1925], 'After': [1926, 1940, 2384], 'culture': [1927, 3889, 3907, 3919, 3991], 'overnight,': [1928], 'incubated': [1933, 2361], 'test': [1935], 'samples': [1936, 1958], 'h.': [1939], 'incubation,': [1941], 'luciferase': [1942, 1965, 3778, 3804, 4165], 'activity': [1943, 1966, 2341, 3637, 3779, 3805, 3812, 3843, 3899, 4334, 4391], 'measured': [1945, 2230, 2825], 'PicaGene': [1948], 'LT': [1949], '2.0': [1950, 3017], '(Toyo': [1952], 'Ink).': [1953], 'Agonistic': [1954], 'activities': [1955, 4073], 'detected': [1960, 3773, 3791, 4075], 'increase': [1963, 3748, 3776, 3802], 'presence': [1969, 3782], 'forskolin': [1971], '(2': [1972], 'μm).': [1973], 'Structual': [1974], 'Analysis': [1975], 'QRFP—Matrix-assisted': [1977], 'laser': [1978], '(MALDI-TOF)': [1981], 'mass': [1982, 2035, 4239, 4281, 4420, 4434, 4463, 4473], 'spectrometry': [1983, 4240, 4464], 'Voyager-DE': [1988], 'PRO': [1989], 'Applied': [1991], 'Biosystems).': [1992], 'Samples': [1993], 'mixed': [1995, 2357], 'matrix': [1998], 'α-cyano-4-hydroxycinnamic': [2000], 'MALDI': [2004], 'target.': [2005], 'External': [2006], 'calibration': [2007], 'ACTH': [2011], '(7–38)': [2012], 'insulin.': [2014], 'Data': [2015], 'linear': [2020, 4036, 4466], 'delayed': [2022, 4460], 'extraction': [2023, 4461], 'mode': [2024, 4467], 'positive': [2026], 'polarity.': [2027], 'According': [2028], 'manufacturer,': [2031], 'under': [2032, 2675, 2704], 'conditions': [2034], 'accuracy': [2036], '0.05%': [2039], 'level': [2040], 'can': [2041], 'achieved.': [2043], 'cAMP': [2044, 2116, 2339], 'Assays—We': [2045], 'vectors': [2048], 'cDNAs': [2052, 2601, 3067, 3076], 'each': [2064, 2702, 2769, 3088, 3507, 4041], 'GPCR.': [2065, 3277], 'Synthetic': [2066], 'QRFPs': [2067, 2228], 'suppression': [2113], 'forskolin-induced': [2115], 'production': [2117], '(12Fukusumi': [2126], 'Takekawa': [2130], 'Kizawa': [2132], 'Sakamoto': [2134], 'Miyamoto': [2136], 'Kitano': [2140], '232:': [2149], '157-163Crossref': [2150], '(145)': [2153], 'Ca2+Mobilization': [2156], 'Assays—Ca2+': [2157], 'mobilization': [2158], 'assays': [2159, 2244, 4046, 4063], 'stable': [2162], 'line': [2165], '(CHO-hAQ27)': [2168], 'mock': [2171], 'elsewhere': [2178, 2439], '(13Hosoya': [2179], 'Moriya': [2181], 'Ohkubo': [2185], 'Matsui': [2189], '29528-29532Abstract': [2210], '(109)': [2218], 'Changes': [2221], 'intracellular': [2223], 'Ca2+': [2224], 'concentrations': [2225, 2795, 2823], 'induced': [2226], '(FLIPR;': [2237], 'Amersham': [2238, 2328], 'Biosciences).': [2239], 'Receptor': [2240, 3243], 'Binding': [2241], 'Assays—Receptor': [2242], 'principally': [2247], 'brief,': [2308], 'tyrosine': [2310], 'residue': [2311, 4127, 4289, 4502], 'synthetic': [2313, 3290, 3848, 4322, 4378], '<EDEGSEATGFLPAAGEKTSGPLGNLAEELNGYSRKKGGFSFRFamide,': [2317], 'where': [2318, 2718, 2920], '<E': [2319], 'indicates': [2320, 4271], 'acid)': [2322], 'radioiodinated': [2324], 'Na125I': [2326], '(IMS-30,': [2327], 'Biosciences)': [2329], 'lactoperoxidase.': [2332], 'labeling': [2334], 'did': [2335, 3187, 4476], 'affect': [2337], 'production-inhibitory': [2340], '(data': [2347, 3392, 3806, 3830, 4339], 'shown).': [2349, 3394, 3808, 3832, 4341], 'membrane': [2351, 2393], 'CHO-hAQ27': [2354], '[125I-Tyr32]QRFP': [2359, 2389], 'room': [2363], 'temperature': [2364, 2684], '90': [2366], 'To': [2368, 2800, 3587, 3866, 3921], 'determine': [2369, 4278], 'amount': [2371], 'nonspecific': [2373], 'binding,': [2374], 'unlabeled': [2377], 'added': [2380], 'mixture.': [2383], 'filtration,': [2385], 'radioactivity': [2387], 'bound': [2390], 'determined.': [2396], 'Quantification': [2397], 'Rat': [2399], 'RT-PCR—': [2405], 'Poly(A)+': [2406], 'tissues,': [2413], 'levels': [2417, 4163], 'quantitatively': [2424], 'means': [2427], '7700': [2434], 'detector': [2436], '(14Fujii': [2440], '21068-21074Abstract': [2463], '(190)': [2471], 'following': [2475, 4303], 'primer': [2476], 'sets': [2477, 2811], 'probes': [2479, 2592], 'used:': [2481], '5′-AGCACACTGGCTTCCGTCTAG-3′,': [2482], '5′-CGCTGGCCTTCTCTGAGTCA-3′,': [2483], '5′(FAM)-AGGCAGGACAGTGGCAGTGAAGCC-(TAMRA)3′': [2485], '5′-CGGAAGCCTGGGAATTCTG-3′,': [2491], '5′-ATGTGTCTCCTTTGGTTTCTTCCA-3′,': [2492], '5′(FAM)-AGCAAAGTTATCTCGACCACAGCGTCCA-(TAMRA)3′': [2494], 'mRNA.': [2498], 'uracil-N-glycosylase': [2512], 'prevent': [2514], 'carried': [2518], 'products,': [2521], 'activation': [2530, 3738, 3793], 'AmplyTaq': [2532], 'Gold': [2533], 'polymerase,': [2535], '15': [2544], '57': [2548], '80': [2551], 'amplification.': [2555], 'Situ': [2557], 'Hybridization—Under': [2558], 'pentobarbital': [2559, 2706], 'anesthesia,': [2560], 'male': [2561], 'Wistar': [2562, 2660], '(8–9': [2564, 2662], 'weeks': [2565, 2663], 'old)': [2566, 2664], 'perfused': [2568], '4%': [2570], 'paraformaldehyde': [2571], 'via': [2572, 2751], 'left': [2574], 'cardiac': [2575], 'ventricle.': [2576], 'Frozen': [2577], 'sections': [2578], 'brains': [2582], 'glands': [2585], 'hybridized': [2587], 'digoxigenin-labeled': [2589], 'antisense': [2590], 'full-length': [2595], 'according': [2602], 'floating': [2605], '(15Fujiwara': [2609], 'Maruyama': [2611], 'Usui': [2613], 'Sakai': [2615], 'Inoue': [2623], 'Neurosci.': [2625], '338:': [2628], '127-130Crossref': [2629], '(13)': [2632], 'Visualization': [2635], 'alkaline': [2644], 'phosphatase-conjugated': [2645], 'anti-digoxigenin': [2646], 'antibody': [2647, 3932], '4-nitroblue': [2649], 'tetrazolium': [2650], 'chloride': [2651], '5-bromo-4-chloro-3-indolyl': [2653], 'phosphate.': [2654], 'Assays': [2655], 'Plasma': [2657, 2793], 'Hormone': [2658], 'Concentrations—Male': [2659], 'food': [2668], 'water': [2670], 'ad': [2671], 'libitum': [2672], 'kept': [2674, 2721], 'controlled': [2676], 'lighting': [2677], '(lights': [2678], '8:00': [2680], '20:00)': [2682], '°C)': [2686], 'until': [2687], 'experiments.': [2691, 2727], 'A': [2692], 'cannula': [2693], 'inserted': [2695, 2753], 'right': [2698, 2748], 'jugular': [2699, 2749], 'vein': [2700, 2750], 'sodium': [2705], 'anesthesia': [2707], '(50': [2708], 'mg/kg).': [2709], 'cannula-implanted': [2711], 'housed': [2714], 'individual': [2716], 'cages': [2717], 'days': [2724], 'before': [2725], 'day': [2729], 'implantation,': [2732], 'phosphate-buffered': [2736], 'saline': [2737], 'either': [2738], 'or': [2740, 2918, 2933, 3092, 3498, 4285, 4499], 'without': [2741], 'injected': [2745], 'cannula.': [2754], 'Before': [2755], 'injection': [2758], 'peptide,': [2761], '400': [2762], 'blood': [2765], 'withdrawn': [2767], 'cannula,': [2773], '0.01': [2775], 'm': [2776, 4014, 4020], 'EDTA': [2777], 'aprotinin': [2779], '(300': [2780], 'kallikrein-inactivating': [2781], 'units/ml)': [2782], 'immediately': [2784], 'added.': [2785], 'between': [2789], '13:00': [2790], '17:00.': [2792], 'aldosterone': [2794], 'radioimmunoassay.': [2799], 'analyze': [2801], 'other': [2802, 2810, 3193, 4258], 'hormones': [2805], 'corticosterone': [2807], 'testosterone),': [2809], 'treated': [2815, 3796], 'manner,': [2819], 'plasma': [2822], 'Identification': [2885, 3240], 'Novel': [2888], 'Peptide': [2890], 'Gene—We': [2891], 'unknown': [2894], 'queries': [2908], 'detect': [2910, 3894], 'repetitive': [2911], 'patterns': [2912, 2949], 'generating': [2913], 'RFGR': [2917, 3109, 3609], 'RFGK': [2919], 'RF': [2921], 'amide': [2928], 'donor': [2929], 'R': [2932], 'K': [2934], 'proteolytic': [2937], 'cleavage': [2938], 'site)': [2939], 'secretory': [2942, 3105], 'upstream': [2946], 'Signal': [3009], 'sequences': [3010, 3058, 3207, 3477], 'predicted': [3012, 3142, 3171, 3558, 4480], 'SignalP': [3015], 'Version': [3016], 'software': [3018], 'program': [3019], '(16Nielsen': [3020], 'Brunak': [3022], 'Heijne': [3024], 'V.G.': [3025], 'Protein': [3026], 'Eng.': [3027], '12:': [3029], '3-9Crossref': [3030], '(536)': [3033], 'By': [3036], 'search,': [3038], 'possibly': [3046], 'encoded': [3047, 3077], 'QRFP).': [3052], 'On': [3053], 'detected,': [3059], 'human,': [3062, 3480], 'bovine,': [3063], 'rat,': [3064, 3481], 'preproproteins': [3078], 'lengths': [3082, 3495], '124–136': [3084], '(Fig.': [3085, 3183, 4241], '1).': [3086], '17': [3091], '18': [3093], 'thought': [3101, 3854], 'comprise': [3103], 'Two': [3108], 'motifs': [3110, 4312], 'preproprotein.': [3116, 3158], 'motif': [3118, 3154, 3610], 'side': [3122], 'conserved': [3124], 'different': [3127], 'species,': [3128], 'but': [3129, 3386, 4331], 'not.': [3135], 'analyses,': [3140], '(QRFP)': [3147], 'would': [3148, 3269, 3862], 'produced': [3150, 4247], 'noticed': [3162], 'GGFSFRF-amide)': [3175], 'quite': [3176], 'resembled': [3177], 'Met-enkephalinamide': [3180, 3390], 'YGGFMRFamide)': [3182], '2).': [3184], 'show': [3189, 3863], 'apparent': [3190], 'homology': [3191, 3519], 'known': [3194, 3209, 4494], 'mammalian': [3195], 'except': [3198], 'structure.Fig.': [3202], '2Comparison': [3203], 'Residues': [3214], 'boxed.': [3220], 'PrRP,': [3221], 'peptide;': [3223], 'NPFF,': [3224], 'FF;': [3226], 'NPAF,': [3227], 'AF;': [3229], 'MetEnk-amide,': [3230], 'Met-enkephalinamide.View': [3231], 'Large': [3232], 'Image': [3233], 'Figure': [3234], 'ViewerDownload': [3235], 'Hi-res': [3236], 'image': [3237], 'Download': [3238], '(PPT)': [3239], 'QRFP—As': [3245, 3840], 'all': [3246], 'act': [3255, 3581], 'certain': [3259], 'GPCRs,': [3260], 'presumed': [3262], 'also': [3270], 'ligand': [3274, 3584], 'exposing': [3289], 'GPCR,': [3383], 'weakly': [3385], 'public': [3410], 'information': [3412], '(GenBank™': [3413], 'accession': [3414], 'AQ270411),': [3416], 'identical': [3423], 'GPR103': [3425, 3555], '(17Lee': [3429], 'D.K.': [3430], 'Nguyen': [3431], 'Lynch': [3433], 'K.R.': [3434], 'Cheng': [3435], 'Vanti': [3437], 'W.B.': [3438], 'Arkhitko': [3439], 'Lewis': [3441], 'George': [3445], 'S.R.': [3446], "O'Dowd": [3447], 'B.F.': [3448], '(Amst.).': [3450], '83-91Crossref': [3453], '(166)': [3456], 'counterparts': [3465], 'respective': [3468], 'deduced': [3478], 'aligned': [3486], 'Supplemental': [3488], 'Fig.': [3489, 4092], '1.': [3490, 4116], 'These': [3491], 'had': [3492, 4311], '431': [3497], '433': [3499], 'showed': [3501, 3518, 4197, 4329, 4387], '84–96%': [3502], 'identity': [3505], 'other.': [3508], 'Among': [3509], 'known,': [3516], 'OT7T022': [3521], '(the': [3522, 3528], 'RFRP)': [3525], 'HLWAR77': [3527], 'FF),': [3532], '32%': [3537], 'identity,': [3540], 'respectively,': [3541], 'Gapped': [3546], 'Blast': [3547], 'program.': [3548], 'As': [3549, 3785, 3891], 'result': [3551], 'phylogenic': [3553], 'analysis,': [3554], '(18Joost,': [3565], 'P.,': [3566], 'Methner,': [3568], '(2002)': [3570], 'Genome': [3571], 'Biol.,': [3572], 'http://genomebiology.com/2002/3/11/RESEARCH/0063,Google': [3573], 'inferred': [3577], 'might': [3580], 'AQ27.': [3586], 'examine': [3588], 'this,': [3589, 3868], 'short': [3593, 3630, 3664, 3985], 'length': [3599], '7': [3601], '(GGFSFRFamide).': [3602, 3989], 'derived': [3604, 4179], 'because,': [3616], 'peptides,': [3619, 4316], 'portions': [3621], 'essential': [3623, 4352], 'sites': [3624], 'bind': [3626], 'receptors,': [3627], 'frequently': [3633], 'retain': [3634], '(19Yoshida': [3638], '1593:': [3654], '151-157Crossref': [3655], '(147)': [3658], 'subjected': [3662], 'assay': [3668, 3682, 4338], 'transiently': [3672, 4050], '(cAMP-responsive': [3679], 'element-luciferase).': [3680], 'modified': [3684, 3758], 'Chen': [3689], 'et': [3690], 'al.': [3691], '(20Durocher': [3692], 'Perret': [3694], 'Thibaudeau': [3696], 'E.': [3697], 'Gaumond': [3698], 'M.H.': [3699], 'Kamen': [3700], 'Stocco': [3702], 'Abramovitz': [3704], 'Anal.': [3706, 3724], '284:': [3709], '316-326Crossref': [3710], '(96)': [3713], '21Chen': [3716], 'W.': [3717], 'Shields': [3718], 'T.S.': [3719], 'Stork': [3720], 'P.J.': [3721], 'Cone': [3722], 'R.D.': [3723], '1995;': [3726], '226:': [3727], '349-354Crossref': [3728], 'They': [3734], 'demonstrated': [3735], 'coupled': [3741, 3787], 'Gs': [3743], 'and/or': [3744], 'Gq': [3745, 3763, 3770], 'causes': [3746], 'promoter.': [3756], 'detecting': [3762], 'signals': [3764, 3771], 'that,': [3766], 'technique,': [3769], 'forskolin.': [3784], 'Gq,': [3789], 'agonistic': [3811, 3842, 4333, 4390], 'appeared': [3816, 4159], 'very': [3819], 'weak': [3820, 4330], 'effective': [3823, 3882], 'dose': [3824], 'ranging': [3825], '10–5': [3827], '10–6m': [3829], 'Determination': [3833], 'Fully': [3836], 'Active': [3837], 'Form': [3838], '7-amino': [3846, 4323], 'acid-long': [3847, 4324], 'considerably': [3851], 'weak,': [3852], 'longer': [3857], 'form': [3858, 3986, 4383, 4407], 'activity.': [3865, 4166, 4198], 'ascertain': [3867], 'examined': [3879, 4044], 'whether': [3880, 4284], 'secreted': [3886], 'supernatant.': [3890, 3920], 'strong': [3897], 'stimulatory': [3898], 'supernatant,': [3908], 'decided': [3910], 'purify': [3912], 'do': [3922], 'so,': [3923], 'affinity': [3926, 4007], 'column': [3927, 4032, 4070], 'chromatography': [3928], 'monoclonal': [3931], '(1F3)': [3933], 'RFRP-1': [3935], '(22Fukusumi': [3936], 'Yoshida': [3940], '1540:': [3972], '221-232Crossref': [3973], '(155)': [3976], 'Scholar)': [3978], 'because': [3979], '1F3': [3980], 'cross-react': [3982], 'supernatant': [3992, 4002], '(2.4': [3993], 'L)': [3994], 'boiled': [3996], 'centrifuged,': [3998], 'resulting': [4001], 'chromatography.': [4008, 4071], 'Elution': [4009], 'glycine-HCl': [4015], '(pH': [4016], '2.2)': [4017], '0.5': [4019], 'NaCl.': [4021], 'eluate': [4023], 'fractionated': [4026], 'Vydac': [4029], 'C18': [4030], '218TP5415': [4031], '20–35%': [4035], 'gradient': [4037], 'CH3CN,': [4039], 'fraction': [4042], 'gene.': [4057], 'Finally': [4058], 'active': [4059], 'μRPC': [4067], 'C2/C18': [4068], 'SC2.1/10': [4069], 'AQ27-stimulatory': [4072], 'eluted': [4077], 'fractions,': [4078], 'corresponded': [4080], 'least': [4083], 'two': [4084], 'peaks': [4085, 4087, 4095, 4101, 4158], '3A).': [4093], 'Although': [4094, 4274, 4413], 'matched': [4099, 4112], 'absorbance': [4100, 4107, 4131, 4137, 4231], '215': [4103], 'nm,': [4104, 4145], 'main': [4106], 'peak': [4108, 4115, 4139, 4173, 4188, 4208, 4219, 4232], '280': [4110, 4133, 4144], 'nm': [4111], 'only': [4113], 'there': [4123], 'Tyr': [4126], 'should': [4129], 'give': [4130], 'nm.': [4134], 'faint': [4142], 'believe': [4147], 'impurities.': [4151], 'assay,': [4156], 'reach': [4161], 'plateau': [4162], 'Considering': [4167, 4254], 'results,': [4169], 'concluded': [4171, 4261], 'major': [4177, 4193], 'cDNA-transfected': [4183], 'peak,': [4194], 'although': [4195], 'purified': [4205], 'follows.': [4211, 4489], 'quantity': [4214], 'calculated': [4222, 4399, 4432, 4449], 'less': [4225], 'pmol': [4228], 'height,': [4233], 'MALDI-TOF': [4238], '3B)': [4242], 'protonated': [4249], 'ion': [4251], '(m/z': [4252, 4421], '4505.7).': [4253], 'together': [4256], 'evidence,': [4259], '<EDEGSEATGFLPAAGEKTSGPLGNLAEELNGYSRKKGGFSFRFamide': [4269], '(<E': [4270], 'acid).': [4273], 'spectrometric': [4282, 4474], 'amidated,': [4291], 'reasoning.': [4304], '(i)': [4305, 4490], 'knew': [4319], 'significant': [4332], '(ii)': [4342], 'well': [4346, 4493], 'interact': [4357], '(23Mekler': [4361], 'Enzyme': [4363], 'Microb.': [4364], 'Technol.': [4365], '16:': [4367], '450-456Crossref': [4368], '(195)': [4371], '(iii)': [4374], 'confirmed': [4376], 'nonamidated': [4382, 4406, 4437], 'drastically': [4388], 'reduced': [4389], '(Table': [4392], 'I).': [4393], '(iv)': [4394], 'M': [4396, 4415, 4429, 4446], '+': [4397, 4416, 4430, 4447], 'H+': [4398, 4417, 4431, 4448], 'average': [4400, 4419, 4433, 4450], 'masses': [4401, 4451], 'amidated': [4404, 4443], '4504.9': [4409], '4505.9,': [4411], 'observed': [4418], '4505.7)': [4422], 'seemed': [4423], 'closer': [4426], 'form,': [4444], 'within': [4453], 'allowable': [4455], 'error': [4456], 'limit': [4457], '(0.05%)': [4458], 'MALDITOF': [4462], 'external': [4469], 'calibration.': [4470], 'Therefore,': [4471], 'contradict': [4478], 'structure.': [4482], 'glutamine': [4498], 'glutamic': [4500], 'easily': [4504], 'circularized': [4505], 'converted': [4507], '(24Busby': [4511], 'W.H.': [4513], 'Quackenbus': [4514]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1969441974', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 18}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2024-12-09T23:34:29.385254', 'created_date': '2016-06-24'}
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