Hey1 Basic Helix-Loop-Helix Protein Plays an Important Role in Mediating BMP9-induced Osteogenic Differentiation of Mesenchymal Progenitor Cells

Name: Work Video:
Duration: 3 min 30 s
Katie A. Sharff; Wenxin Song; Xiaoji Luo; Ni Tang; Jinyong Luo; Jin Chen; Yang Bi; Bai‐Cheng He; Jiayi Huang; Xinmin Li; Wei Jiang; Gaohui Zhu; Yuxi Su; Yun He; Jikun Shen; Yi Wang; Liang Chen; Guowei Zuo; Bo Liu; Xiaochuan Pan; Russell R. Reid; Hue H. Luu; Rex C. Haydon; Tong‐Chuan He
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[8, 224, 584], 'progenitor': [9, 225], 'that': [11, 24, 41, 64, 89, 107, 170, 196, 227, 240, 257, 280, 305, 323, 386, 412, 1023, 1124, 1458, 1649, 1775, 1826, 1880, 1940, 1951, 1969, 2475, 2573, 3788, 3911, 4191, 4459, 4492, 4511, 4551, 4631], 'can': [12, 228], 'differentiate': [13, 229, 1784], 'into': [14, 230, 2063, 2569, 2598, 2781, 3739, 3946, 4293], 'osteogenic,': [15, 231], 'chondrogenic,': [16, 232], 'adipogenic,': [17, 233], 'and': [18, 36, 53, 62, 130, 133, 148, 159, 234, 252, 269, 278, 346, 349, 364, 375, 579, 778, 842, 846, 890, 978, 1021, 1040, 1294, 1313, 1377, 1380, 1388, 1454, 1657, 1885, 1891, 1912, 1925, 1942, 1950, 1983, 1985, 1995, 2003, 2073, 2088, 2122, 2176, 2224, 2249, 2263, 2269, 2446, 2470, 2543, 2562, 2584, 2608, 2648, 2658, 2787, 2833, 3015, 3018, 3154, 3305, 3322, 3379, 3449, 3691, 3702, 3710, 3728, 3768, 3815, 3903, 3919, 3932, 3944, 3950, 3984, 4019, 4022, 4033, 4047, 4050, 4189, 4208, 4327, 4453, 4475, 4482, 4484, 4531, 4533, 4542, 4558, 4565, 4571], 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'siRNA,': [477, 526], 'small': [478, 527, 538], 'interference': [479, 528], 'RNA;': [480, 529], 'AdGFP,': [481, 530, 3717], 'adenovirus': [482, 531, 2951, 3095, 4525], 'expressing': [483, 532, 2836, 2952, 3012, 3096, 4526], 'only': [484, 533, 2953], 'GFP.5The': [485], 'GFP.': [534], 'represent': [535], 'very': [537], 'fraction': [539], 'total': [542, 2196, 2235, 3292, 4534], 'population': [543], 'nucleated': [545], '(1Pittenger': [550, 586], 'M.F.': [551, 587], 'Mackay': [552, 588], 'A.M.': [553, 589], 'Beck': [554, 590], 'S.C.': [555, 591], 'Jaiswal': [556, 592], 'R.K.': [557, 593], 'Douglas': [558, 594], 'R.': [559, 595, 1405, 1800, 2499, 4149], 'Mosca': [560, 596], 'J.D.': [561, 597], 'Moorman': [562, 598], 'M.A.': [563, 599], 'Simonetti': [564, 600], 'D.W.': [565, 601], 'Craig': [566, 602], 'S.': [567, 603, 735, 2507, 2924, 2939, 3035, 3050], 'Marshak': [568, 604], 'D.R.': [569, 605], 'Science.': [570, 606, 617, 643, 872, 916, 1410, 2980], '1999;': [571, 607, 1676, 1755, 2998], '284:': [572, 608, 835], '143-147Crossref': [573, 609], 'PubMed': [574, 610, 621, 647, 667, 698, 726, 760, 793, 823, 837, 863, 876, 907, 920, 932, 965, 990, 1001, 1116, 1162, 1193, 1235, 1275, 1336, 1358, 1414, 1450, 1495, 1573, 1612, 1679, 1726, 1758, 1817, 1860, 2054, 2314, 2356, 2396, 2433, 2519, 2712, 2771, 2916, 2944, 2984, 3006, 3055, 3089, 3146, 3207, 3247, 3284, 3532, 3563, 3605, 3645, 3682, 3855, 4095, 4284, 4357, 4399, 4439], 'Scopus': [575, 611, 622, 648, 668, 699, 727, 761, 794, 824, 838, 864, 877, 908, 921, 933, 966, 991, 1002, 1077, 1117, 1163, 1194, 1236, 1276, 1359, 1415, 1496, 1534, 1574, 1613, 1680, 1727, 1759, 1818, 1861, 2055, 2315, 2357, 2397, 2434, 2520, 2713, 2772, 2877, 2917, 2945, 2985, 3007, 3056, 3090, 3147, 3208, 3248, 3285, 3493, 3533, 3564, 3606, 3646, 3683, 3856, 4096, 4161, 4245, 4285, 4358, 4400, 4440], '(17841)': [576, 612], 'Google': [577, 613, 624, 635, 650, 670, 701, 729, 745, 763, 796, 826, 840, 866, 879, 910, 923, 935, 968, 993, 1004, 1079, 1119, 1165, 1196, 1238, 1278, 1337, 1361, 1417, 1451, 1498, 1536, 1576, 1615, 1682, 1729, 1761, 1820, 1863, 2057, 2317, 2359, 2399, 2436, 2522, 2715, 2774, 2879, 2919, 2947, 2987, 3009, 3058, 3092, 3149, 3210, 3250, 3287, 3495, 3535, 3566, 3608, 3648, 3685, 3858, 4098, 4163, 4247, 4287, 4360, 4402, 4442], 'Scholar)': [578, 841], 'adherent': [581], 'multipotent': [582], 'Scholar,': [614, 625, 636, 651, 671, 730, 746, 827, 867, 911, 924, 936, 994, 1080, 1166, 1197, 1239, 1338, 1499, 1537, 1577, 2318, 2360, 2400, 2880, 2920, 2988, 3059, 3211, 3251, 3496, 3536, 3567, 3609, 3649, 4099, 4248, 4361, 4403], '2Prockop': [615], 'D.J.': [616], '1997;': [618], '276:': [619], '71-74Crossref': [620], '(4115)': [623], '3Aubin': [626], 'J.E.': [627], 'J.': [628, 681, 692, 738, 753, 786, 829, 853, 897, 938, 1069, 1098, 1145, 1156, 1187, 1217, 1224, 1257, 1264, 1347, 1478, 1489, 1526, 1555, 1579, 1589, 1720, 1810, 1849, 2048, 2308, 2338, 2345, 2378, 2385, 2508, 2688, 2696, 2747, 2755, 2869, 2898, 2929, 3040, 3061, 3071, 3122, 3130, 3189, 3196, 3229, 3236, 3485, 3514, 3557, 3587, 3594, 3627, 3634, 4077, 4109, 4113, 4125, 4145, 4237, 4266, 4340, 4351, 4381, 4388, 4421, 4428], 'Cell.': [629, 754, 854, 898, 1188, 1721, 2049, 2309, 2428, 2997, 3279, 3558, 3677, 3850], 'Biochem.': [630, 787, 1189, 2310, 3559], 'supplemental.': [631], '1998;': [632, 2941, 2981, 3052], '31:': [633], '73-82Crossref': [634], '4Ducy': [637], 'P.': [638, 1062, 1102, 1519, 1559, 2862, 2902, 3478, 3518, 4081, 4230, 4270], 'Schinke': [639], 'T.': [640, 1587, 1593, 1715, 4147], 'Karsenty': [641, 2504], 'G.': [642, 1597, 1601, 2505], '2000;': [644, 1350, 1411, 2511], '289:': [645, 1412], '1501-1504Crossref': [646], '(892)': [649], '5Caplan': [652], 'A.I.': [653, 712], 'Bruder': [654, 713], 'S.P.': [655, 714], 'Trends': [656, 715], 'Mol.': [657, 716, 755, 1602, 2427, 3278, 3676, 3849], 'Med.': [658, 717, 756], '2001;': [659, 718], '7:': [660, 719], '259-264Abstract': [661, 720], 'Full': [662, 664, 721, 723, 858, 860, 902, 904, 1230, 1232, 1270, 1272, 1353, 1355, 1607, 1609, 1855, 1857, 2351, 2353, 2391, 2393, 2514, 2516, 3001, 3003, 3202, 3204, 3242, 3244, 3600, 3602, 3640, 3642, 4394, 4396, 4434, 4436], 'Text': [663, 665, 722, 724, 859, 861, 903, 905, 1231, 1233, 1271, 1273, 1354, 1356, 1608, 1610, 1856, 1858, 2352, 2354, 2392, 2394, 2515, 2517, 3002, 3004, 3203, 3205, 3243, 3245, 3601, 3603, 3641, 3643, 4395, 4397, 4435, 4437], 'PDF': [666, 725, 862, 906, 1234, 1274, 1357, 1611, 1859, 2355, 2395, 2518, 3005, 3206, 3246, 3604, 3644, 4398, 4438], '(947)': [669, 728], '6Luu': [672], 'H.H.': [673, 948, 1056, 1096, 1137, 1180, 1211, 1255, 1470, 1513, 1553, 2301, 2332, 2376, 2406, 2682, 2741, 2856, 2896, 3075, 3116, 3183, 3227, 3257, 3472, 3512, 3550, 3581, 3625, 3655, 3828, 4075, 4153, 4224, 4264, 4332, 4375, 4419], 'Song': [674, 749, 1138, 1471, 2411, 2679, 2738, 3068, 3113, 3262, 3660, 3833, 4102, 4333], 'W.X.': [675, 1139, 1472, 2412, 2680, 2739, 3069, 3114, 3263, 3661, 3834, 4103, 4334], 'Luo': [676, 680, 949, 1097, 1140, 1144, 1202, 1216, 1256, 1473, 1477, 1554, 2323, 2337, 2377, 2409, 2415, 2683, 2687, 2742, 2746, 2897, 3064, 3117, 3121, 3174, 3188, 3228, 3260, 3266, 3513, 3572, 3586, 3626, 3658, 3664, 3831, 3837, 4076, 4104, 4108, 4110, 4265, 4335, 4339, 4366, 4380, 4420], 'X.': [677, 1141, 1174, 1215, 1253, 1474, 2295, 2336, 2374, 2416, 2418, 2684, 2743, 3065, 3118, 3187, 3225, 3267, 3269, 3544, 3585, 3623, 3665, 3667, 3838, 3840, 4111, 4143, 4336, 4379, 4417], 'Manning': [678, 1142, 1475, 4337], 'D.': [679, 748, 1143, 1476, 1585, 1599, 1844, 1846, 2501, 4338], 'Deng': [682, 1146, 1479, 2689, 2748, 3062, 3123, 4341], 'Z.L.': [683, 1147, 1480, 2690, 2749, 3063, 3124, 4342], 'Sharff': [684, 1148, 1481, 2697, 2756, 3072, 3131, 4343], 'K.A.': [685, 1149, 1482, 2698, 2757, 3073, 3132, 4344], 'Montag': [686, 1089, 1150, 1218, 1258, 1483, 1546, 2339, 2379, 2421, 2889, 3190, 3230, 3272, 3505, 3588, 3628, 3670, 3843, 4068, 4257, 4345, 4382, 4422], 'A.G.': [687, 1090, 1151, 1219, 1259, 1484, 1547, 2340, 2380, 2422, 2890, 3191, 3231, 3273, 3506, 3589, 3629, 3671, 3844, 4069, 4258, 4346, 4383, 4423], 'Haydon': [688, 955, 1049, 1107, 1152, 1183, 1220, 1260, 1485, 1506, 1564, 2304, 2341, 2381, 2423, 2703, 2762, 2849, 2907, 3076, 3137, 3192, 3232, 3274, 3465, 3523, 3553, 3590, 3630, 3672, 3845, 4086, 4150, 4217, 4275, 4347, 4384, 4424], 'R.C.': [689, 956, 1050, 1108, 1153, 1184, 1221, 1261, 1486, 1507, 1565, 2305, 2342, 2382, 2424, 2704, 2763, 2850, 2908, 3077, 3138, 3193, 3233, 3275, 3466, 3524, 3554, 3591, 3631, 3673, 3846, 4087, 4218, 4276, 4348, 4385, 4425], 'He': [690, 957, 1067, 1109, 1154, 1185, 1222, 1262, 1487, 1524, 1566, 2306, 2343, 2383, 2425, 2705, 2764, 2867, 2909, 3082, 3139, 3194, 3234, 3276, 3483, 3525, 3555, 3592, 3632, 3674, 3847, 4088, 4116, 4130, 4154, 4235, 4277, 4349, 4386, 4426], 'T.C.': [691, 958, 1068, 1110, 1155, 1186, 1223, 1263, 1488, 1525, 1567, 2307, 2344, 2384, 2426, 2706, 2765, 2868, 2910, 2922, 2962, 2990, 3033, 3083, 3140, 3195, 3235, 3277, 3484, 3526, 3556, 3593, 3633, 3675, 3848, 4089, 4155, 4236, 4278, 4350, 4387, 4427], 'Orthop.': [693, 1157, 1490, 4352], 'Res.': [694, 1158, 1491, 1813, 4353], '2007;': [695, 1159, 1492, 2709, 2768, 3086, 3143, 4354], '25:': [696, 1160, 1493, 4355], '665-677Crossref': [697, 1161, 1494, 4356], '(442)': [700, 1164, 1497, 4359], 'Scholar).': [702, 797, 880, 969, 1005, 1120, 1279, 1362, 1418, 1616, 1864, 2058, 2437, 2523, 2716, 2775, 2948, 3010, 3093, 3150, 3288, 3686, 3859, 4164, 4288, 4443], 'Although': [703, 1419, 1738], 'primarily': [704], 'located': [705], 'within': [706, 2152], 'compartment': [710], '(5Caplan': [711], '7Friedenstein': [731], 'A.J.': [732, 1323, 1437, 2041], 'Piatetzky': [733], 'II,': [734], 'Petrakova': [736], 'K.V.': [737], 'Embryol.': [739], 'Exp.': [740], 'Morphol.': [741], '1966;': [742], '16:': [743], '381-390PubMed': [744], '8Baksh': [747], 'L.': [750, 831, 869, 913, 1054, 1511, 1717, 2854, 2970, 3470, 4139, 4222], 'Tuan': [751], 'R.S.': [752, 1331, 1344, 1407, 1445], '2004;': [757, 790, 1113, 1227, 1267, 1570, 1814, 1852, 2051, 2348, 2388, 2913, 3199, 3239, 3529, 3597, 3637, 4092, 4281, 4391, 4431], '8:': [758], '301-316Crossref': [759], '(896)': [762], 'Scholar),': [764, 1452, 1683, 1730, 1762, 1821], 'have': [766, 883, 1007, 1456], 'been': [767, 884, 1365], 'isolated': [768, 2025, 2199], 'from': [769, 1288, 1990, 2014, 2026], 'periosteum,': [770], 'trabecular': [771], 'bone,': [772], 'adipose': [773], 'tissue,': [774], 'synovium,': [775], 'skeletal': [776, 977], 'muscle,': [777], 'deciduous': [779], 'teeth': [780], '(9Barry': [781], 'F.P.': [782], 'Murphy': [783], 'J.M.': [784, 1798], 'Int.': [785], 'Cell': [788, 1981, 3688], 'Biol.': [789, 833, 1225, 1265, 1348, 1850, 2346, 2386, 2429, 2509, 3197, 3237, 3280, 3595, 3635, 3678, 3851, 4389, 4429], '36:': [791], '568-584Crossref': [792], '(1415)': [795], 'As': [798], 'members': [799], 'transforming': [802], 'growth': [803], 'factor-β': [804], 'superfamily,': [805], 'cell': [813, 844, 1735, 2164, 2785], 'biology': [814], '(10Varga': [815], 'A.C.': [816], 'Wrana': [817, 870, 914], 'J.L.': [818, 871, 915, 2043], 'Oncogene.': [819], '2005;': [820, 834, 962], '24:': [821], '5713-5721Crossref': [822], '(167)': [825], '11Zhang': [828], 'Li': [830, 953, 1105, 1173, 1214, 1252, 1562, 1588, 1590, 2294, 2335, 2373, 2417, 2905, 3186, 3224, 3268, 3521, 3543, 3584, 3622, 3666, 3839, 4084, 4273, 4378, 4416], 'Dev.': [832, 928, 986, 1675, 1754, 4158], '1-11Crossref': [836], '(175)': [839], 'regulate': [843, 887, 1127], 'proliferation': [845, 1319], 'during': [848, 981], 'development': [849, 982], '(12Shi': [850, 894], 'Y.': [851, 895, 944, 954, 1052, 1088, 1106, 1168, 1199, 1251, 1509, 1545, 1563, 1719, 2289, 2320, 2372, 2852, 2888, 2906, 3171, 3223, 3468, 3504, 3522, 3538, 3569, 3621, 4067, 4085, 4115, 4123, 4127, 4131, 4137, 4220, 4256, 4274, 4363, 4415], 'Massague': [852, 896], '2003;': [855, 899, 998, 1074, 1190, 1531, 1723, 2311, 2874, 3490, 3560, 4242], '113:': [856, 900], '685-700Abstract': [857, 901], '(4764)': [865, 909], '13Attisano': [868, 912], '2002;': [873, 917, 1604], '296:': [874, 918], '1646-1647Crossref': [875, 919], '(1123)': [878, 922], 'Several': [881], 'subsequent': [891], 'formation': [893, 1379], '14Hogan': [925], 'B.L.': [926, 984, 1792], 'Genes': [927, 985], '1996;': [929, 987], '10:': [930, 988], '1580-1594Crossref': [931, 989], '(1718)': [934, 992], '15Luo': [937], 'Sun': [939, 1083, 1175, 1540, 2296, 2883, 3499, 3545, 4062, 4251], 'M.H.': [940, 1084, 1176, 1541, 2297, 2884, 3500, 3546, 4063, 4252], 'Kang': [941, 1169, 1200, 1242, 2290, 2321, 2363, 2403, 2677, 2736, 3111, 3172, 3214, 3254, 3539, 3570, 3612, 3652, 3825, 4364, 4406], 'Q.': [942, 950, 1082, 1170, 1201, 1203, 1241, 1243, 1539, 2291, 2322, 2324, 2362, 2364, 2404, 2410, 2676, 2678, 2735, 2737, 2882, 3110, 3112, 3173, 3175, 3213, 3215, 3255, 3261, 3498, 3540, 3571, 3573, 3611, 3613, 3653, 3659, 3826, 3832, 4061, 4101, 4105, 4250, 4365, 4367, 4405, 4407], 'Peng': [943, 1051, 1087, 1250, 1508, 1544, 2371, 2851, 2887, 3222, 3467, 3503, 3620, 4066, 4219, 4255, 4414], 'Jiang': [945, 1045, 1093, 1177, 1204, 1246, 1502, 1550, 2298, 2325, 2367, 2413, 2691, 2750, 2845, 2893, 3125, 3176, 3218, 3264, 3461, 3509, 3547, 3574, 3616, 3662, 3835, 4072, 4120, 4213, 4261, 4368, 4410], 'W.': [946, 1046, 1094, 1178, 1205, 1207, 1245, 1247, 1503, 1551, 1807, 2299, 2326, 2328, 2366, 2368, 2402, 2414, 2692, 2751, 2846, 2894, 3126, 3177, 3179, 3217, 3219, 3253, 3265, 3462, 3510, 3548, 3575, 3577, 3615, 3617, 3651, 3663, 3824, 3836, 4073, 4121, 4214, 4262, 4369, 4371, 4409, 4411], 'Luu': [947, 1055, 1095, 1179, 1210, 1254, 1512, 1552, 2300, 2331, 2375, 2405, 2681, 2740, 2855, 2895, 3074, 3115, 3182, 3226, 3256, 3471, 3511, 3549, 3580, 3624, 3654, 3827, 4074, 4152, 4223, 4263, 4374, 4418], 'Park': [951, 1065, 1103, 1181, 1212, 1248, 1522, 1560, 2302, 2333, 2369, 2407, 2865, 2903, 3184, 3220, 3258, 3481, 3519, 3551, 3582, 3618, 3656, 3829, 4082, 4118, 4233, 4271, 4376, 4412], 'J.Y.': [952, 1066, 1104, 1182, 1523, 1561, 2303, 2866, 2904, 3482, 3520, 3552, 4083, 4234, 4272], 'Curr.': [959], 'Gene.': [960], 'Ther.': [961, 1112, 1569, 1603, 2912, 3528, 4091, 4280], '5:': [963], '167-179Crossref': [964], '(90)': [967], 'Genetic': [970], 'disruptions': [971], 'result': [974], 'various': [976], 'extraskeletal': [979], 'abnormalities': [980], '(14Hogan': [983], '16Zhao': [995], 'G.Q.': [996], 'Genesis.': [997], '35:': [999], '43-56Crossref': [1000], '(303)': [1003], 'recently': [1008, 2671, 2730, 3105, 4179], 'comprehensive': [1011], 'activity': [1016, 1431, 3423], '14': [1018, 4194], 'human': [1019, 1315, 1422], 'BMP9': [1024, 1280, 1304, 1316, 1363, 1423, 1461, 1934, 2837, 4196, 4317, 4469, 4506, 4516, 4527, 4623, 4643], 'promoting': [1032], '(17Cheng': [1043, 2843, 3459, 4211], 'H.': [1044, 1086, 1172, 1501, 1543, 1591, 1595, 2293, 2420, 2694, 2753, 2844, 2886, 2968, 3128, 3271, 3460, 3502, 3542, 3669, 3842, 4065, 4133, 4212, 4254], 'Phillips': [1047, 1504, 2847, 3463, 4215], 'F.M.': [1048, 1325, 1439, 1505, 2848, 3464, 4216], 'Zhou': [1053, 1510, 2853, 2923, 3034, 3469, 4221], 'An': [1057, 1514, 2685, 2744, 2857, 2949, 3119, 3473, 4225], 'N.': [1058, 1515, 1842, 2686, 2700, 2745, 2759, 2858, 3067, 3120, 3134, 3474, 4107, 4226], 'Breyer': [1059, 1516, 2859, 3475, 4227], 'B.': [1060, 1403, 1517, 1581, 1671, 1750, 2860, 2933, 2977, 2994, 3044, 3081, 3476, 4228], 'Vanichakarn': [1061, 1101, 1518, 1558, 2861, 2901, 3477, 3517, 4080, 4229, 4269], 'Szatkowski': [1063, 1099, 1520, 1556, 2863, 2899, 3479, 3515, 4078, 4231, 4267], 'J.P.': [1064, 1100, 1521, 1557, 2864, 2900, 3480, 3516, 4079, 4232, 4268], 'Bone': [1070, 1527, 1811, 2870, 3486, 4238], 'Joint': [1071, 1528, 2871, 3487, 4239], 'Surg.': [1072, 1529, 2872, 3488, 4240], 'Am.': [1073, 1530, 2873, 3489, 4241], '85A:': [1075, 1532, 2875, 3491, 4243], '1544-1552Crossref': [1076, 1533, 2876, 3492, 4244], '(803)': [1078, 1535, 2878, 3494, 4246], '18Kang': [1081, 1538, 2881, 3497, 4249], 'Cheng': [1085, 1171, 1542, 2292, 2885, 3501, 3541, 4064, 4253], 'Deyrup': [1091, 1548, 2891, 3507, 4070, 4259], 'A.T.': [1092, 1549, 2892, 3508, 4071, 4260], 'Gene': [1111, 1568, 2707, 2766, 2911, 3141, 3527, 4090, 4279], '11:': [1114, 1571, 2914, 3530, 4093, 4282], '1312-1320Crossref': [1115, 1572, 2915, 3531, 4094, 4283], '(497)': [1118, 1575, 2918, 3534, 4097, 4286], 'also': [1122, 2574], 'distinct': [1129], 'set': [1130, 2530], '(6Luu': [1136, 1469, 4331], '19Peng': [1167, 3537], '90:': [1191, 2312, 3561], '1149-1165Crossref': [1192, 2313, 3562], '(164)': [1195, 2316, 3565], '20Peng': [1198, 2319, 3568, 4362], 'Si': [1206, 1244, 2327, 2365, 3178, 3216, 3576, 3614, 4370, 4408], 'Liu': [1208, 2329, 3180, 3578, 4372], 'B.A.': [1209, 2330, 3181, 3579, 4373], 'J.K.': [1213, 1249, 1409, 2334, 2370, 2408, 3185, 3221, 3259, 3583, 3619, 3657, 3830, 4119, 4377, 4413], 'Chem.': [1226, 1266, 1349, 1851, 2347, 2387, 2510, 3198, 3238, 3596, 3636, 4390, 4430], '279:': [1228, 1268, 1853, 2349, 2389, 3200, 3240, 3598, 3638, 4392, 4432], '32941-32949Abstract': [1229, 2350, 3201, 3599, 4393], '(184)': [1237, 2358, 3209, 3607, 4401], '21Luo': [1240, 2361, 3212, 3610, 4404], '55958-55968Abstract': [1269, 2390, 3241, 3639, 4433], '(269)': [1277, 2398, 3249, 3647, 4441], '(also': [1281, 1651], 'known': [1282, 1652, 1836, 2261], 'as': [1283, 1653, 2032, 2134, 2186, 2285, 2605, 2629, 2808, 2840, 2958, 3030, 3168, 3324, 3397, 3433, 3456, 3820, 3988, 4057, 4596], 'GDF2)': [1284], 'originally': [1286], 'fetal': [1289, 2107, 2173, 2221], 'liver': [1291], 'cDNA': [1292, 3298, 3314], 'libraries': [1293], 'relatively': [1297], 'uncharacterized': [1298], 'member': [1299], 'BMP': [1302], 'family.': [1303], 'highly': [1306, 1463], 'expressed': [1307, 1460, 2264], 'developing': [1310], 'liver,': [1312], 'recombinant': [1314, 1421, 2610, 2789], 'stimulates': [1317], 'hepatocyte': [1318], '(22Song': [1320, 1434], 'J.J.': [1321, 1435], 'Celeste': [1322, 1436], 'Kong': [1324, 1438], 'Jirtle': [1326, 1440], 'R.L.': [1327, 1441], 'Rosen': [1328, 1442], 'V.': [1329, 1443], 'Thies': [1330, 1343, 1406, 1444], 'Endocrinology.': [1332, 1446], '1995;': [1333, 1447], '136:': [1334, 1448], '4293-4297Crossref': [1335, 1449], '23Miller': [1339], 'A.F.': [1340], 'Harvey': [1341], 'S.A.': [1342], 'Olson': [1345], 'M.S.': [1346], '275:': [1351, 2512], '17937-17945Abstract': [1352], '(132)': [1360], 'has': [1364, 3912], 'synergistic': [1371], 'factor': [1372, 1661], 'for': [1373, 2124, 2246, 2480, 2525, 2666, 2724, 3405, 3725, 3730, 3765, 3774, 3782, 4010], 'hematopoietic': [1374], 'progenitor-cell': [1375], 'generation': [1376], 'colony': [1378], 'induction': [1387], 'maintenance': [1389], 'neuronal': [1392], 'cholinergic': [1393], 'phenotype': [1394], 'central': [1397], 'nervous': [1398], 'system': [1399, 2674, 2733, 3108], '(24Lopez-Coviella': [1400], 'I.': [1401], 'Berse': [1402], 'Krauss': [1404], 'Blusztajn': [1408], '313-316Crossref': [1413], '(199)': [1416], 'exert': [1428], 'little': [1429], 'osteoinductive': [1430, 4203], 'others': [1455], 'exogenously': [1459], 'capable': [1464], 'inducing': [1466], '17Cheng': [1500], '25Jane': [1578], 'Dunford': [1580], 'Kron': [1582], 'A.': [1583, 1669, 1748, 1796, 2940, 3051], 'Pittman': [1584], 'Sasaki': [1586], 'Alden': [1592], 'Dayoub': [1594], 'Hankins': [1596], 'Kallmes': [1598], 'Helm': [1600], '6:': [1605], '464Abstract': [1606], '(81)': [1614], 'However,': [1617], 'molecular': [1619, 4295], 'mechanism': [1620, 1635], 'behind': [1621], 'BMP9-regulated': [1622, 1637], 'MSC': [1623, 1979, 2557, 4187], 'remains': [1625], 'elucidated.': [1628], 'In': [1629], 'this': [1630, 2149, 2635, 2816], 'study,': [1631], 'investigated': [1633], 'underlying': [1636], 'lineage-specific': [1639], 'Through': [1643], 'analysis,': [1646], 'Hesr1,': [1654], 'HRT1,': [1655], 'CHF2,': [1656], 'HERP2),': [1658], 'transcription': [1660, 1703, 3302], 'HERP': [1664, 1698], '(26Leimeister': [1666, 1745], 'C.': [1667, 1746, 2038, 2966], 'Externbrink': [1668, 1747], 'Klamt': [1670, 1749], 'Gessler': [1672, 1751], 'M.': [1673, 1752, 1848], 'Mech.': [1674, 1753], '85:': [1677, 1756], '173-177Crossref': [1678, 1757], '(210)': [1681, 1760], 'response': [1694, 1932, 4504], 'BMP9.': [1696], 'The': [1697, 2115, 2239, 2267, 2438, 2483, 2581, 2593, 2622, 2717, 2801, 2810, 3094, 3311, 3327, 3367, 3875], 'factors': [1704], 'Notch': [1711], 'pathway': [1713], '(27Iso': [1714], 'Kedes': [1716], 'Hamamori': [1718], 'Physiol.': [1722, 2050], '194:': [1724], '237-255Crossref': [1725], '(1012)': [1728], 'which': [1731], 'implicated': [1733], 'fate': [1736], 'decision.': [1737], 'somitogenesis': [1744], 'unclear.': [1771], 'One': [1772], 'study': [1773, 1824, 2150], 'specifically': [1778], 'BMP2': [1781], 'when': [1782], '(28de': [1788], 'Jong': [1789], 'D.S.': [1790], 'Vaes': [1791], 'Dechering': [1793], 'K.J.': [1794], 'Feijen': [1795], 'Hendriks': [1797], 'Wehrens': [1799], 'Mummery': [1801], 'C.L.': [1802], 'van': [1803, 2039], 'Zoelen': [1804], 'E.J.': [1805], 'Olijve': [1806], 'Steegenga': [1808], 'W.T.': [1809], 'Miner': [1812], '19:': [1815], '947-958Crossref': [1816], '(78)': [1819], 'whereas': [1822, 2451], 'another': [1823], 'showed': [1825], 'inhibited': [1828], 'maturation': [1830], 'via': [1831], 'interaction': [1832], 'regulator': [1837], '(29Zamurovic': [1841], 'Cappellen': [1843], 'Rohner': [1845], 'Susa': [1847], '37704-37715Abstract': [1854], '(196)': [1862], 'sought': [1866], 'determine': [1868, 3968], 'functional': [1870], 'BMP-9': [1889], 'reduced': [1905], 'overexpression': [1916], 'increased': [1919, 4562], 'vitro,': [1924], 'enhanced': [1926], 'mineralization': [1927], 'further': [1938, 2444, 3317, 3380, 4291], 'provides': [1956, 3926], 'partial': [1958], 'rescue': [1959], 'phenotype.': [1964], 'results': [1967, 4629], 'mediating': [1977], 'Culture': [1982], 'Chemicals—HEK293': [1984], 'C3H10T1/2': [1986, 2211, 2616, 2795, 3706, 3799, 4313, 4322, 4519], 'lines': [1987], 'obtained': [1989], 'ATCC': [1992], '(Manassas,': [1993], 'VA)': [1994], 'maintained': [1996, 2214], 'complete': [1998, 2168], "Dulbecco's": [1999, 2101], 'modified': [2000, 2102], "Eagle's": [2001, 2103], 'medium': [2002, 2005, 2104, 2169, 2217], 'basal': [2004, 2216, 4578], 'Eagle,': [2006], 'respectively.': [2007], 'Unless': [2008], 'indicated,': [2009], 'all': [2010, 2465, 2481], 'chemicals': [2011], 'purchased': [2013], 'Sigma': [2015], 'or': [2016, 2188, 2228, 3718, 3723, 3795, 3805, 3864, 4318, 4528, 4593], 'Fisher': [2017], 'Scientific.': [2018], 'Isolation': [2019, 2155], 'Mouse': [2021, 2655], 'Embryo': [2022], 'Fibroblasts—MEFs': [2023], 'post': [2027], 'coitus': [2028], 'day': [2029, 4584], '13.5': [2030], 'mice,': [2031], 'described': [2034, 2287, 2842, 3031, 3169, 3458, 3822, 4059], '(30Lengner': [2035], 'C.J.': [2036], 'Lepper': [2037], 'Wijnen': [2040], 'Stein': [2042, 2044], 'G.S.': [2045], 'Lian': [2046], 'J.B.': [2047], '200:': [2052], '327-333Crossref': [2053], '(67)': [2056], 'Each': [2059], 'dissected': [2062], '10-ml': [2064], 'sterile': [2065], 'phosphate-buffered': [2066], 'saline,': [2067], 'voided': [2068], 'internal': [2071], 'organs,': [2072], 'sheared': [2074], '18-gauge': [2077], 'syringe': [2078], 'presence': [2081, 3876], '1': [2083, 2089], 'ml': [2084], '0.25%': [2086], 'trypsin': [2087], 'mm': [2090], 'EDTA.': [2091], 'After': [2092], '15-min': [2093], 'incubation': [2094], 'gentle': [2096], 'shaking': [2097], '37': [2099, 2128], '°C,': [2100], '10%': [2106, 4030], 'calf': [2108, 2174, 2222], 'serum': [2109, 2175, 2223], 'added': [2111], 'inactivate': [2113], 'trypsin.': [2114], 'plated': [2118], 'on': [2119, 3387], '100-mm': [2120], 'dishes': [2121], 'incubated': [2123], '24': [2125], 'h': [2126, 2232, 3809], '°C.': [2129], 'Adherent': [2130], 'MEF': [2135, 3784], 'cells.': [2136], 'Aliquots': [2137], 'kept': [2139], 'liquid': [2142], 'nitrogen': [2143], 'tank.': [2144], 'All': [2145, 3151, 3408], 'MEFs': [2146, 3790], 'five': [2153], 'passages.': [2154], 'Total': [2157], 'RNA—Subconfluent': [2158], 'seeded': [2161], '75-cm2': [2163], 'culture': [2165], 'flasks': [2166], 'supplemented': [2170], '0.5%': [2172, 2220], 'infected': [2177, 2225, 3714, 3792, 3802, 4522], 'predetermined': [2180], 'optimal': [2181], 'titer': [2182], 'adenoviruses,': [2184], 'such': [2185], 'AdBMP9': [2187, 2227], 'AdGFP.': [2189, 2229], 'At': [2190, 2230, 3757, 3807], 'time': [2193], 'after': [2194, 2233, 3760, 3810, 4545, 4580], 'infection,': [2195, 2234, 3811], 'RNA': [2197, 2236, 2242, 3293, 4535], 'using': [2200, 2277, 2490, 2669, 2728, 3026, 3103, 3337, 3360, 3885], 'TRIzol': [2201], 'reagents': [2202], '(Invitrogen),': [2203], 'according': [2204], "manufacturer's": [2207], 'instructions.': [2208], 'Microarray': [2209], 'Analysis—Subconfluent': [2210, 3798], 'Eagle': [2218], 'containing': [2219], '30': [2231, 3808, 4471], 'isolated.': [2238], 'fully': [2240], 'samples': [2243, 2466, 3409, 4009], 'preparation': [2248], 'subjected': [2250, 3816, 3904], 'hybridizations': [2252], 'Affymetrix': [2254, 2278], 'chips': [2257], '430A': [2258], '(containing': [2259], '∼22,000': [2260, 4310], 'genes': [2262, 2460, 2474, 2528, 4311, 4461, 4472, 4502], 'sequence': [2265, 3880], 'tags).': [2266], 'acquisition': [2268], 'initial': [2270], 'quantitation': [2271], 'array': [2273], 'images': [2274], 'performed': [2276, 4304], 'MAS': [2279], '5.0': [2280], 'default': [2283], 'parameters': [2284], '(19Peng': [2288], '31Si': [2401, 3252, 3650], 'Yin': [2419, 2693, 2752, 3127, 3270, 3668, 3841, 4132], '2006;': [2430, 3281, 3679, 3852], '26:': [2431, 3282, 3680, 3853], '2955-2964Crossref': [2432, 3283, 3681, 3854], '(236)': [2435, 3286, 3684, 3857], 'acquired': [2439, 3943], 'microarray': [2440], 'raw': [2441], 'data': [2442, 3941], 'filtered': [2445], 'normalized': [2447, 3411], 'remove': [2449], 'noise,': [2450], 'retaining': [2452], 'true': [2453], 'biological': [2454], 'information': [2455], 'filtering': [2457], 'out': [2458, 2488, 3167, 3359, 3404, 4056], 'signal': [2462, 2540], 'intensity': [2463, 2468, 2541], '<100': [2467], 'units,': [2469, 2542], 'removing': [2472], 'received': [2476], '"absent"': [2478], 'call': [2479], 'hybridizations.': [2482], 'clustering': [2484], 'carried': [2487, 3166, 3358, 3403, 4055], 'DNA-Chip': [2492], 'Analyzer': [2493], '(dChip)': [2494], 'software': [2495], '(51McLarren': [2496], 'K.W.': [2497, 2931, 2979, 2996, 3042, 3079], 'Lo': [2498], 'Grbavec': [2500], 'Thirunavukkarasu': [2502], 'K.': [2503], 'Stifani': [2506], '530-538Abstract': [2513], '(151)': [2521], 'Thresholds': [2524], 'selecting': [2526], 'significant': [2527], 'relative': [2533], 'difference': [2534, 2538, 2546], '>2-fold,': [2535], 'absolute': [2537], '>100': [2539], 'statistical': [2545], 'p': [2548, 4454], '<': [2549, 4455], '0.05': [2550], '(supplemental': [2551, 2663, 3330], 'Table': [2552, 2664, 3331, 4486], 'S1).': [2553, 4487], 'Establishment': [2554], 'Stable': [2556], 'Lines': [2558], 'Expressing': [2559, 2829], 'Hey1—We': [2560, 2656], 'PCR-amplified': [2561, 2585, 3152], 'cloned': [2563], 'coding': [2567, 2586], 'region': [2568], 'retroviral': [2571, 2600, 2783], 'vector': [2572, 2595, 2604], 'conferred': [2575], 'resistance': [2576], 'blasticidin,': [2578], 'designated': [2579, 2628, 2807], 'RV-Hey1.': [2580], 'cloning': [2582, 3155], 'regions': [2583, 2587], 'verified': [2589, 2638, 2819, 3158, 3374], 'DNA': [2591, 3160, 3363], 'sequencing.': [2592, 3161], 'RV-Hey1': [2594], 'transfected': [2597, 2780], 'packaging': [2601], 'line': [2602, 2636, 2817], '(empty': [2603], 'control),': [2607], 'retrovirus': [2611, 2790], 'infect': [2615, 2794], 'followed': [2618, 2797, 3781], 'blasticidin': [2620, 2799], 'selection.': [2621, 2800], 'resultant': [2623, 2802], 'stable': [2624, 2803], 'pooled': [2625, 2804], 'clones': [2626, 2805], 'C3H10-Hey1.': [2630], 'Overexpression': [2631], 'qPCR.': [2640, 2821], 'Construction': [2641, 2647, 2822], 'details': [2642, 2823], 'available': [2644, 2825], 'upon': [2645, 2826, 4468], 'request.': [2646, 2827], 'Validation': [2649], 'siRNA': [2651, 2660, 3099], 'Expression': [2652], 'Vectors': [2653], 'Targeting': [2654], 'constructed': [2657], 'validated': [2659], 'sites': [2662, 2720, 3771], 'S2)': [2665, 3332], 'developed': [2672, 2731, 3106], 'pSOS': [2673, 2732], '(32Luo': [2675, 2734, 3109], 'Chen': [2695, 2754, 3070, 3129, 4112, 4138], 'Tang': [2699, 2758, 3066, 3133, 4106, 4122], 'Bennett': [2701, 2760, 3135], 'E.': [2702, 2761, 3136], '(Amst.).': [2708, 2767, 3142], '395:': [2710, 2769, 3144], '160-169Crossref': [2711, 2770, 3145], '(83)': [2714, 2773, 3148], 'selected': [2718], 'first': [2722, 3312], 'screened': [2723], 'their': [2725], 'efficiency': [2727], 'These': [2776, 3999], 'vectors,': [2777], 'RV-sim-Hey1,': [2778], 'packing': [2784], 'line,': [2786, 3708], 'C3H10-Hey1KD.': [2809], 'Adenoviruses': [2828, 3011], 'BMP9,': [2830, 4557], 'simHey1—Recombinant': [2834], 'adenoviruses': [2835], 'generated': [2839, 3021, 3102], '33He': [2921], 'da': [2925, 2971, 3036], 'Costa': [2926, 2972, 3037], 'L.T.': [2927, 2973, 3038], 'Yu': [2928, 3039], 'Kinzler': [2930, 2978, 2995, 3041, 3078], 'Vogelstein': [2932, 2976, 2993, 3043, 3080], 'Proc.': [2934, 3045], 'Natl.': [2935, 3046], 'Acad.': [2936, 3047], 'Sci.': [2937, 3048], 'U.': [2938, 3049], '95:': [2942, 3053], '2509-2514Crossref': [2943, 3054], '(3235)': [2946, 3057], 'analogous': [2950], 'GFP': [2954, 4320, 4529], '(AdGFP)': [2955], 'control': [2960, 3707, 3865], '(34He': [2961], 'Sparks': [2963], 'A.B.': [2964], 'Rago': [2965], 'Hermeking': [2967], 'Zawel': [2969], 'Morin': [2974], 'P.J.': [2975], '281:': [2982], '1509-1512Crossref': [2983], '(4058)': [2986], '35He': [2989], 'Chan': [2991], 'T.A.': [2992], '99:': [2999], '335-345Abstract': [3000], '(1031)': [3008], '(AdHey1': [3017], 'AdRunx2)': [3019], 'same': [3024], 'fashion': [3025], 'AdEasy': [3028], 'technology': [3029], '(33He': [3032], '36Luo': [3060], 'Nat.': [3084], 'Protoc.': [3085], '2:': [3087], '1236-1247Crossref': [3088], '(675)': [3091], '(Ad-simHey1)': [3100], 'pSES': [3107], 'fragments': [3153], 'junctions': [3156], 'qPCR': [3162, 3164, 3325, 3328, 3355, 3371], 'Analysis—The': [3163], '(20Peng': [3170], 'Ten': [3289], 'micrograms': [3290], 'generate': [3297], 'templates': [3299], 'reverse': [3301, 3308], 'hexamer': [3304], 'Superscript': [3306], 'II': [3307], 'transcriptase': [3309], '(Invitrogen).': [3310], 'strand': [3313], 'products': [3315, 3386], 'diluted': [3318], '5-': [3319], '10-fold': [3321, 4566], 'templates.': [3326], 'primers': [3329, 3889], '18-mers,': [3334], 'designed': [3335], 'Primer3': [3339], 'program,': [3340], 'frodo.wi.mit.edu/cgi-bin/primer3/primer3_www.cgi,': [3341], 'amplify': [3343], '3′-end': [3345], '(∼120': [3346], 'bp)': [3347], 'interest.': [3352], 'SYBR': [3353], 'Green-based': [3354], 'Opticon': [3362], 'Engine': [3364], '(MJ': [3365], 'Research).': [3366], 'specificity': [3368], 'each': [3370, 3406, 3935, 3938, 3960, 3973, 3995, 4011], 'reaction': [3372], 'melting': [3376], 'curve': [3377], 'confirmed': [3381], 'resolving': [3383], 'PCR': [3385, 3884], '1.5%': [3388], 'agarose': [3389], 'gels.': [3390], 'pUC19,': [3391], '5-fold': [3392], 'serially': [3393], 'diluted,': [3394], 'standard.': [3399], 'Duplicate': [3400], 'reactions': [3401], 'sample.': [3407], 'level': [3415, 4561], 'glyceraldehyde-3-phosphate': [3417], 'dehydrogenase.': [3418], 'Measurement': [3419], 'ALP': [3421, 4601], 'Activity—ALP': [3422], 'assessed': [3425], 'colorimetric': [3428], 'assay': [3429, 3439], '(using': [3430, 3440], 'p-nitrophenyl': [3431], 'phosphate': [3432, 3448], 'substrate)': [3435], 'and/or': [3436], 'histochemical': [3437], 'staining': [3438], 'mixture': [3442], '0.1': [3444], 'mg/ml': [3445, 3451], 'napthol': [3446], 'AS-MX': [3447], '0.6': [3450], 'Fast': [3452], 'Blue': [3453, 4024, 4052], 'BB': [3454], 'salt)': [3455], 'Stem': [3687, 4156], 'Implantation—The': [3689], 'use': [3690], 'care': [3692], 'animals': [3694, 3762], 'approved': [3696], 'Institutional': [3699], 'Animal': [3700], 'Care': [3701], 'Use': [3703], 'Committee.': [3704], 'Subconfluent': [3705], 'C3H10-Hey1,': [3709], 'C3H10-Hey1KD': [3711], 'AdBMP9,': [3716, 3721], 'co-infected': [3719], 'AdRunx2,': [3722], 'AdHey1': [3724], '15': [3726], 'h,': [3727], 'collected': [3729, 4537], 'subcutaneous': [3731], 'injection': [3732, 4013], '(5': [3733], '×': [3734], '106': [3735], 'per': [3737, 3749], 'injection)': [3738], 'flanks': [3741], 'athymic': [3743], 'nude': [3744], '(nu/nu)': [3745], 'mice': [3746], '(four': [3747], 'injections': [3748], 'group,': [3750], '4-': [3751], '6-week-old,': [3753], 'male,': [3754], 'Harlan': [3755], 'Sprague-Dawley).': [3756], '6': [3758], 'weeks': [3759], 'implantation,': [3761], 'sacrificed': [3764, 3900], 'MicroCT': [3766, 3896, 3909, 3940], 'imaging,': [3767], 'implantation': [3770, 3785], 'retrieved': [3773], 'histologic': [3775], 'evaluation.': [3776], 'A': [3777, 4481], 'similar': [3778], 'procedure': [3779], 'experiments,': [3786], 'except': [3787], 'Ad-simHey1': [3794], 'AdHey1.': [3796], 'ChIP': [3797, 3818, 4647], 'AdGFP': [3804], 'AdBMP9.': [3806], 'cross-linked': [3814], '(31Si': [3823], 'Smad4': [3860], 'antibody,': [3861, 3863], 'Smad1/5/8': [3862], 'IgG': [3866], 'pull': [3870], 'down': [3871], 'protein-DNA': [3873], 'complexes.': [3874], 'promoter': [3879, 3894], 'detected': [3882], 'three': [3886], 'pairs': [3887], 'corresponding': [3890], 'region.': [3895], 'Imaging': [3897], 'Analysis—Animals': [3898], 'end-points': [3902], 'high': [3907, 3921, 4450], 'performance': [3908], 'imager': [3910], 'spatial': [3914], 'resolution': [3915], '10-50': [3917], 'μm': [3918], 'contrast': [3922], 'resolution.': [3923], 'This': [3924, 4488], 'unit': [3925], 'measurements': [3928], 'regarding': [3929], 'number': [3931, 4007], 'volume': [3933, 3958, 3985], 'mass': [3936, 3952], 'animal.': [3939], 'reconstructed': [3945], 'three-dimensional': 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[4126], 'Zhu': [4128], 'G.H.': [4129], 'Hu': [4134], 'Z.': [4135], 'Wang': [4136], 'Zuo': [4140], 'G.W.': [4141], 'Pan': [4142], 'Shen': [4144], 'Vokes': [4146], 'Reid': [4148], 'H.C.': [4151], 'Cells': [4157], '2008;': [4159], 'https://doi.org/10.1089/scd.2008.0130Crossref': [4160], '(302)': [4162], 'Is': [4166], 'Among': [4167], 'Most': [4169], 'Significantly': [4170], 'Up-regulated': [4171], 'Targets': [4172], 'Osteogenic': [4175], 'Differentiation': [4176], 'MSCs—We': [4178], 'evaluated': [4180], 'BMPs,': [4195], 'gain': [4290], 'insight': [4292], 'basis': [4296], 'MSCs,': [4302, 4518], 'profiling': [4307], 'stimulated': [4315], 'control.': [4321], 'commonly': [4325], 'well': [4328, 4604], 'Using': [4444, 4547], 'dChip': [4446, 4489], 'under': [4448], 'stringency': [4451], '(>2.0-fold': [4452], '0.05),': [4456], 'found': [4458], '40': [4460], 'regulated': [4465], 'stimulation;': [4470], '10': [4476], 'down-regulated': [4478], '(Fig.': [4479, 4507, 4609], '1,': [4480, 4539, 4569], 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