Morphometry of nucleoli and expression of nucleolin analyzed by laser scanning cytometry in mitogenically stimulated lymphocytes

Name: Work Video:
Duration: 3 min 30 s
Wojciech Gorczyca; Piotr Smolewski; Jerzy Grabarek; Barbara Ardelt; Masamichi Ita; Myron R. Melamed; Zbigniew Darżynkiewicz
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138, 159, 226, 256, 260, 285, 289, 323, 344, 421, 431, 444, 455, 475, 479, 502, 511, 521, 533, 548, 573, 582, 584, 614, 633, 661, 679, 689, 709, 711, 718, 728, 739, 751, 764, 789, 798, 819, 842, 855, 875, 897, 917, 919, 942, 948, 954, 975, 979, 1023, 1033, 1089, 1103, 1108, 1156, 1160, 1167, 1179, 1185, 1207, 1215, 1301, 1304, 1311, 1357, 1369, 1376, 1380, 1390, 1399, 1419, 1426, 1511, 1523, 1610, 1736, 1747, 1777, 1839, 1854, 1867, 1892, 1895, 1905, 1910, 1924, 1929, 1943, 1957, 2009, 2036, 2044, 2055, 2064, 2107, 2112, 2128, 2149, 2175, 2178, 2212, 2215, 2220, 2246, 2259, 2267, 2274, 2316, 2324, 2363, 2373, 2423, 2426, 2435, 2453, 2458, 2474, 2476, 2516, 2531, 2552, 2558, 2616, 2630, 2633, 2660, 2686, 2692, 2710, 2716, 2727, 2738, 2748, 2772, 2796, 2808, 2826, 2840, 2852, 2861, 2891, 2907, 2923, 2931, 2954, 2975, 2987, 3001, 3011, 3033, 3046, 3089, 3093, 3108, 3178, 3183, 3189, 3193, 3198, 3244, 3275, 3334, 3341, 3363, 3395, 3401, 3403, 3414, 3421, 3465, 3517, 3539, 3556, 3600, 3618, 3623, 3625, 3653, 3668, 3673, 3716, 3718, 3726, 3745, 3749, 3753, 3777, 3783, 3810, 3818, 3840, 3848, 3857, 3866, 3876, 3889, 3900, 3918, 3927, 3959, 3997, 4016, 4026, 4047, 4108, 4116, 4125, 4143, 4153, 4187, 4245, 4259, 4267, 4280, 4321, 4356, 4371, 4435, 4442, 4471, 4476, 4492, 4502, 4509], 'nucleoli': [11, 529, 564, 574, 680, 692, 920, 1104, 1432, 1930, 2065, 2268, 2739, 2779, 2841, 2855, 2924, 2955, 3018, 3090, 3158, 3184, 3194, 3245, 3325, 3351, 3377, 3405, 3422, 4090], 'and': [12, 140, 325, 419, 423, 435, 442, 461, 488, 495, 530, 542, 551, 558, 579, 590, 603, 650, 670, 672, 685, 734, 793, 807, 816, 839, 846, 853, 865, 869, 881, 914, 923, 933, 951, 1019, 1055, 1091, 1101, 1136, 1183, 1189, 1195, 1199, 1246, 1259, 1284, 1293, 1296, 1362, 1383, 1393, 1414, 1421, 1431, 1435, 1463, 1495, 1513, 1534, 1542, 1552, 1594, 1622, 1660, 1710, 1795, 1801, 1873, 1883, 1933, 1941, 1961, 1967, 1983, 1994, 2004, 2026, 2066, 2074, 2084, 2103, 2110, 2135, 2146, 2153, 2202, 2222, 2224, 2299, 2308, 2366, 2438, 2525, 2561, 2574, 2594, 2650, 2672, 2745, 2805, 2813, 2836, 2888, 2925, 2947, 2956, 3019, 3041, 3091, 3118, 3152, 3187, 3195, 3204, 3213, 3225, 3285, 3293, 3309, 3339, 3360, 3441, 3448, 3506, 3512, 3534, 3565, 3568, 3576, 3609, 3855, 4089, 4098, 4139, 4240, 4263, 4276, 4317, 4325, 4348, 4388, 4399, 4488], 'expression': [13, 532, 583, 717, 1214, 1258, 1428, 2452, 2475, 2490, 2685, 2709, 2851, 2928, 2958, 3092, 3667, 3717, 3725, 3856, 3917], 'nucleolin': [15, 537, 1148, 1257, 1684, 1944, 2619, 2684, 2711, 2828, 2927, 2957, 2988, 3012, 3034, 3048], 'analyzed': [16, 1884, 3135], 'by': [17, 53, 82, 111, 131, 150, 171, 207, 238, 267, 296, 316, 335, 356, 392, 760, 1041, 1277, 1318, 1328, 1433, 1439, 1537, 1547, 1557, 1572, 1601, 1769, 1775, 1808, 2058, 2079, 2105, 2141, 2244, 2281, 2568, 2607, 2646, 2821, 2959, 3207, 3247, 3291, 3298, 3328, 3331, 3337, 3423, 3583, 3803, 4082, 4135, 4172, 4323, 4339], 'laser': [18, 523, 1079, 1794], 'scanning': [19, 524, 1080], 'cytometry': [20, 1093], 'in': [21, 539, 587, 595, 720, 731, 779, 824, 850, 861, 877, 888, 903, 962, 966, 985, 991, 1007, 1020, 1059, 1099, 1176, 1218, 1227, 1256, 1345, 1387, 1403, 1429, 1458, 1528, 1550, 1575, 1607, 1625, 1633, 1640, 1654, 1662, 1674, 1700, 1708, 1744, 1756, 1764, 1953, 1959, 2072, 2123, 2180, 2187, 2239, 2261, 2337, 2341, 2348, 2443, 2471, 2480, 2507, 2511, 2537, 2543, 2548, 2556, 2675, 2683, 2752, 2778, 2850, 2854, 2876, 2885, 2889, 2917, 2921, 2926, 3054, 3096, 3105, 3136, 3174, 3202, 3211, 3221, 3346, 3353, 3366, 3384, 3389, 3439, 3445, 3450, 3459, 3488, 3500, 3527, 3531, 3549, 3670, 3714, 3723, 3728, 3742, 3751, 3773, 3781, 3808, 3812, 3845, 3873, 3916, 3939, 3955, 3968, 3982, 4007, 4023, 4035, 4054, 4076, 4156, 4213, 4292, 4359, 4408, 4415, 4439, 4464, 4482, 4506], 'mitogenically': [22, 556, 986], 'stimulated': [23, 987, 1536, 2019, 2190, 2309, 2459, 2579, 2941, 3113, 3280, 4056], 'lymphocytes': [24, 554, 989, 1109, 1526, 1535, 1965, 1968, 2216, 2329, 2340, 2350, 2460, 2563, 2571, 2575, 2641, 2934, 2940, 3109, 3125, 3147, 3540, 3660, 3708, 3906, 4484], 'Wojciech': [25, 27, 210, 212], 'Gorczyca,': [26, 211], 'Gorczyca': [28, 213], 'Brander': [29, 59, 88, 117, 180, 214, 244, 273, 302, 365], 'Cancer': [30, 60, 89, 118, 181, 191, 215, 245, 274, 303, 366, 376], 'Research': [31, 61, 90, 119, 182, 192, 216, 246, 275, 304, 367, 377], 'Institute,': [32, 62, 91, 120, 183, 217, 247, 276, 305, 368], 'New': [33, 38, 43, 48, 63, 68, 92, 97, 121, 126, 161, 166, 184, 189, 218, 223, 228, 233, 248, 253, 277, 282, 306, 311, 346, 351, 369, 374], 'York': [34, 39, 44, 64, 69, 93, 98, 122, 162, 185, 219, 224, 229, 249, 254, 278, 283, 307, 347, 370], 'Medical': [35, 45, 65, 73, 94, 123, 163, 186, 220, 230, 250, 258, 279, 308, 348, 371], 'College,': [36, 46, 66, 95, 124, 164, 187, 221, 231, 251, 280, 309, 349, 372], 'Valhalla,': [37, 47, 67, 96, 125, 165, 188, 222, 232, 252, 281, 310, 350, 373], 'Department': [40, 70, 99, 137, 158, 225, 255, 284, 322, 343], 'Pathology,': [42, 101, 160, 227, 286, 345], 'YorkSearch': [49, 127, 167, 234, 312, 352], 'for': [50, 79, 108, 128, 147, 168, 204, 235, 264, 293, 313, 332, 353, 389, 492, 971, 1067, 1396, 1486, 1539, 1597, 1642, 1657, 1666, 1725, 1758, 1902, 1974, 2022, 2193, 2289, 2582, 2589, 2760, 2944, 3116, 3146, 3283, 3546, 3605, 3794, 4059, 4181, 4289, 4306, 4392], 'more': [51, 80, 109, 129, 148, 169, 205, 236, 265, 294, 314, 333, 354, 390, 960, 2031, 2046, 2345, 3712, 4208], 'papers': [52, 81, 110, 130, 149, 170, 206, 237, 266, 295, 315, 334, 355, 391], 'this': [54, 83, 112, 132, 151, 172, 208, 239, 268, 297, 317, 336, 357, 393, 456, 931, 1626, 2390, 2407, 3270, 3451, 3928, 4148, 4182, 4223, 4357, 4466], 'authorPiotr': [55, 240], 'Smolewski,': [56, 241], 'Piotr': [57, 242], 'Smolewski': [58, 243], 'Hematology,': [72, 257], 'University': [74, 259], 'Lodz,': [76, 77, 261, 262], 'PolandSearch': [78, 107, 263, 292], 'authorJerzy': [84, 269], 'Grabarek,': [85, 270], 'Jerzy': [86, 271], 'Grabarek': [87, 272], 'Pomeranian': [102, 287], 'School': [103, 288], 'Medicine,': [105, 290], 'Szczecin,': [106, 291], 'authorBarbara': [113, 298], 'Ardelt,': [114, 299], 'Barbara': [115, 300], 'Ardelt': [116, 301], 'authorMasamichi': [133, 318], 'Ita,': [134, 319], 'Masamichi': [135, 320], 'Ita': [136, 321], 'Oral': [139, 324], 'Maxillofacial': [141, 326], 'Surgery,': [142, 327], 'Yamaguchi': [143, 328], 'University,': [144, 329], 'Ube,': [145, 330], 'JapanSearch': [146, 331], 'authorMyron': [152, 337], 'R.': [153, 156, 338, 341], 'Melamed,': [154, 339], 'Myron': [155, 340], 'Melamed': [157, 342], 'authorZbigniew': [173, 358], 'Darzynkiewicz,': [174, 359], 'Corresponding': [175, 360], 'Author': [176, 361], 'Zbigniew': [177, 362], 'Darzynkiewicz': [178, 363], '[email protected]': [179, 364], 'YorkBrander': [190, 375], 'Institute': [193, 378], 'at': [194, 379, 559, 706, 1366, 1385, 1410, 1643, 1647, 1697, 1722, 1761, 2048, 2143, 2232, 2313, 2865, 3303, 4192, 4202, 4430], 'NYMC,': [195, 380], '19': [196, 381], 'Bradhurst': [197, 382], 'Ave.,': [198, 383], 'Suite': [199, 384], '2400,': [200, 385], 'Hawthorne,': [201, 386], 'NY': [202, 387], '10532Search': [203, 388], 'author': [209, 394], 'First': [395], 'published:': [396], '31': [397], 'October': [398], '2001': [399, 831], 'https://doi.org/10.1002/1097-0320(20011101)45:3<206::AID-CYTO1164>3.0.CO;2-9Citations:': [400], '11AboutSectionsPDF': [401], 'ToolsRequest': [402], 'permissionExport': [403], 'citationAdd': [404], 'to': [405, 427, 450, 516, 527, 597, 600, 621, 693, 742, 774, 785, 800, 812, 929, 996, 1095, 1121, 1134, 1211, 1235, 1251, 1289, 1424, 1822, 1850, 1936, 2061, 2114, 2263, 2396, 2465, 2714, 2764, 2952, 2982, 3060, 3079, 3240, 3253, 3296, 3357, 3398, 3456, 3496, 3707, 3768, 3842, 3909, 3934, 3963, 3991, 4071, 4127, 4141, 4232, 4255, 4261, 4264, 4298, 4331, 4423, 4426, 4451, 4511], 'favoritesTrack': [406], 'citation': [407], 'ShareShare': [408], 'Give': [409], 'accessShare': [410, 413], 'full': [411], 'text': [412], 'full-text': 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2830, 2886, 3027, 3051, 3190, 3196, 3475, 3860, 3880, 3922, 3940, 3971, 3983, 4002, 4017, 4036, 4158, 4410], 'product': [482, 978, 3437], '(rRNA),': [483], 'correlate': [484, 543, 934, 1051, 1279, 3241], 'cell-proliferative': [486, 1016, 1053], 'status': [487, 788], 'are': [489, 754, 858, 874, 885, 908, 958, 1126, 1516, 2441, 2644, 3644], 'useful': [490, 909], 'markers': [491, 1300], 'tumor': [493, 794, 944, 1024], 'diagnosis': [494], 'prognosis.': [496, 795], 'However,': [497, 2334], 'there': [498, 2869], 'is': [499, 735, 836, 847, 982, 1011, 1171, 2070, 2121, 2447, 3219, 3434, 3443, 3468, 3633, 3695, 3949, 4066, 4184, 4217, 4296, 4380, 4462, 4480, 4485, 4495], 'paucity': [501], 'methods': [503, 916, 925], 'that': [504, 710, 822, 1037, 1085, 1125, 1272, 2226, 2249, 2450, 2506, 2535, 2696, 2715, 2801, 3068, 3345, 3406, 3482, 3698, 4044, 4064, 4079, 4132, 4185, 4226, 4461], 'can': [505, 809, 1038, 1286], 'quantitatively': [506], 'probe': [507], 'nucleolus.': [508, 2333, 3381], 'The': [509, 571, 796, 834, 946, 1145, 1204, 1269, 1335, 1636, 1921, 2053, 2119, 2209, 2271, 2294, 2409, 2664, 2689, 2770, 2785, 2902, 3479, 3498, 3720, 3838, 3886, 3911, 3937, 3970, 4020, 4062, 4095, 4177, 4437], 'aim': [510], 'present': [513, 1074], 'study': [514, 813, 1122, 1627], 'was': [515, 627, 683, 695, 1162, 1232, 1243, 1613, 1773, 1806, 1833, 1848, 1997, 2087, 2157, 2228, 2242, 2279, 2344, 2394, 2412, 2461, 2478, 2519, 2597, 2605, 2611, 2621, 2755, 2819, 2832, 2856, 2870, 2896, 2969, 3003, 3103, 3144, 3371, 3425, 3581, 3603, 3711, 3739, 3756, 3891, 3915, 3930, 3943, 3975, 4004, 4052, 4189, 4197, 4207, 4285, 4412], 'utilize': [517], 'morphometric': [519, 1205], 'capacity': [520], 'cytometer': [525, 1081, 2162], '(LSC)': [526], 'analyze': [528, 2765], 'measure': [531, 801, 1823, 1937, 3030, 3843], 'protein': [536, 803, 1153, 3861, 3929, 4196, 4221, 4346, 4358], '(NCL)': [538, 1857], 'individual': [540, 1219, 3017, 3335], 'cells': [541, 618, 664, 746, 759, 902, 964, 1295, 1336, 1446, 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4155], 'immunocytochemically': [567, 1146, 2555, 3780], 'using': [568, 1885, 2089, 2757, 2961, 3249, 3310], 'NCL': [569, 634, 641, 690, 719, 765, 1170, 1216, 1427, 1958, 2007, 2179, 2227, 2325, 2427, 2454, 2477, 2489, 2517, 2534, 2553, 2590, 2749, 2809, 2853, 2877, 2892, 3094, 3162, 3199, 3409, 3442, 3669, 3727, 3750, 3778, 3811, 3862, 3998, 4027, 4048, 4154, 4188, 4206, 4216, 4248, 4260, 4295, 4308, 4322, 4372, 4406], 'Ab.': [570], 'frequency': [572, 1100, 1928, 2725, 2737, 3088, 3651, 3832], 'per': [575, 635, 642, 681, 700, 1222, 1931, 2740, 2829, 2894, 3023, 3050, 3185, 3307, 4014], 'nucleus,': [576, 701, 1862, 1932, 2524, 2741], 'area,': [578, 2638, 3941, 4030], 'level': [581, 632, 699, 763, 2473, 3163, 3388, 3809, 3926, 4152, 4164, 4407], 'NCL,': [585, 2045], 'separately': [586, 1217], 'nuclear': [589, 1913, 2637, 2652, 2804, 4385], 'compartments,': [592], 'estimated': [594, 3201, 3604, 3628], 'relation': [596], 'G0': [599, 620, 712, 741, 758, 1133, 2697, 3080, 3495, 3700, 3905, 3935, 3990, 4231, 4422, 4450, 4483, 4510], 'G1': [601, 622, 743, 1135, 4142, 4424, 4452], 'transition': [602, 1131, 3493, 3908, 3988, 4229, 4420], 'cell': [605, 733, 1002, 1117, 1130, 1143, 1229, 1274, 1282, 1305, 1406, 2049, 2318, 2387, 2483, 3519, 3523, 3611, 3704, 3987, 4087, 4302, 4313], 'cycle': [606, 753, 3595], 'progression.': [607], 'Results': [608, 2422], 'During': [609, 656, 3985, 4147], 'first': [611, 1828, 3289, 3895, 4499], '24': [612, 1645, 1975, 2290, 2794, 3896, 4060, 4106, 4193, 4500], 'h': [613, 660, 1416, 1544, 1646, 1976, 1981, 1985, 2024, 2028, 2291, 2584, 2795, 2860, 2906, 2949, 3064, 3287, 3548, 3766, 3796, 3800, 3817, 3897, 4107, 4113, 4194, 4204, 4434, 4501], 'stimulation,': [615, 662, 4109, 4504], 'when': [616, 663, 772, 871, 3349, 3903, 4234], 'underwent': [619, 3826, 3907, 4249], 'transition,': [623, 744], 'RNA': [625, 1005, 1196, 1436, 2076, 2085, 2102, 3433, 3461, 3467, 3489, 3501, 3533, 3575, 4273, 4473, 4479, 4493], 'content': [626, 953, 974, 1242, 1437, 2086, 2724, 3188, 3462, 3490, 3502, 3536, 3593, 3643, 3650, 3831, 4470], 'increased': [628, 638, 644, 648, 653, 684, 2811, 4005, 4053], 'nearly': [629, 654, 2822, 2834, 2847, 3122, 3485], '8-fold,': [630, 639], 'nucleus': [636, 682, 845, 1223, 3186, 4169], 'also': [637, 1233, 1244, 1297, 2229, 2405, 2734, 2897, 3665, 4381], 'nucleolus': [643, 806, 835, 950, 1872, 2336, 2539, 3948, 4051, 4065, 4254, 4398], '12-fold,': [645, 2814], 'nucleolear': [646], 'area': [647, 652, 1940, 2653, 2674, 2818, 2831, 2887, 2895, 3956, 4037], '3-fold,': [649, 2823], 'NCL/nucleolar': [651], '4-fold.': [655], 'subsequent': [658], '24–48': [659, 2859, 2900, 4112], 'progressing': [666, 747, 4241], 'through': [667, 748, 1141, 4131, 4242, 4270], 'S,': [668, 3505, 3608, 4128], 'G2,': [669, 4137], 'M': [671], 'reentering': [673], 'next': [675, 4105, 4145], 'cycle,': [676, 2319, 4247], 'number': [678, 1904, 2063, 2839, 3022, 3182, 3243], 'massive': [687], 'translocation': [688, 804, 4251, 4386, 4395], 'from': [691, 757, 1132, 1320, 1448, 1501, 1630, 1858, 1870, 1948, 1969, 2011, 2283, 2296, 2351, 2576, 2718, 2989, 3038, 3110, 3148, 3223, 3231, 3277, 3494, 3834, 3989, 4230, 4252, 4421, 4449], 'nucleoplasm': [694, 808, 2214, 2260, 2275, 3368], 'observed;': [696], 'its': [697, 955, 3446, 4163, 4290, 4333, 4384], 'overall': [698, 762], 'however,': [702, 2864, 3141, 3942, 4069], 'still': [703], 'remained': [704], 'high,': [705], '6-fold': [707, 2848], 'above': [708], 'cells.': [713, 883, 2467, 3656, 3747, 3814, 3936], 'Conclusions': [714], 'While': [715, 2389, 3215], 'high': [716, 761, 2647, 2703], 'compartment': [723, 4003, 4159, 4411], 'correlates': [724, 1014], 'rate': [727, 3888, 4441, 4491], 'rRNA': [729, 4262, 4362, 4364, 4443], 'accumulation': [730, 4291], 'sensitive': [737, 3616], 'marker': [738, 1166], 'remainder': [750, 4244], 'better': [755], 'distinguished': [756], 'within': [766, 1912, 2455, 3920, 4000, 4049, 4166, 4200], 'nucleus.': [768, 2626, 2993, 4319], 'Such': [769], 'an': [770, 1083, 1889, 3964], 'analysis,': [771, 1253], 'applied': [773], 'tumors,': [775, 890], 'may': [776, 4092, 4351, 4389, 4402, 4457], 'be': [777, 810, 1039, 1263, 1287, 2504, 3134, 4072, 4093, 4390], 'helpful': [778, 4463], 'obtaining': [780], 'quantitative': [782, 1299], 'parameters': [783, 3057, 3881], 'related': [784], 'kinetic': [787], 'tumor-cell': [791], 'population': [792], 'capability': [797], 'LSC': [799, 1208, 1278, 1770, 1780, 1896, 1925, 2761, 3002, 3292, 3316, 3329, 3338, 3424, 3841], 'between': [805, 879, 1291, 2858, 2899, 2904, 3087, 3181, 3369, 3503, 4111, 4300, 4311, 4396, 4445], 'used': [811, 928, 1163, 1288, 2060], 'function': [815], 'regulatory': [817], 'mechanisms': [818], 'other': [820, 3359, 3404], 'proteins': [821, 1036, 1063, 4269], 'reside': [823], 'these': [825, 924, 1168, 1273, 2115, 2773, 3320, 3376, 3626, 3835, 3879], 'compartments.': [826], 'Cytometry': [827, 2081], '45:206–213,': [828], '2001.': [829], '©': [830], 'Wiley-Liss,': [832], 'Inc.': [833, 1505], 'structural': [838], 'functional': [840, 4354], 'suborganelle': [841], "cell's": [844], 'primarily': [848], 'involved': [849, 3444], 'synthesis': [852, 3447, 4444], 'processing': [854, 1182, 3449], 'rRNA.': [856], 'Nucleoli': [857, 884], 'distinctly': [859, 2383], 'visible': [860], 'routine': [862], 'hematoxylin-eosin': [863], 'preparations,': [864], 'number,': [867, 3852], 'size,': [868], 'shape,': [870], 'carefully': [872], 'analyzed,': [873], 'help': [876], 'differentiating': [878], 'malignant': [880, 893, 938], 'benign': [882, 940], 'very': [886, 2321, 2378, 2845, 3354, 4486], 'pronounced': [887, 961, 2047, 2912, 3913], 'some': [889, 2338, 2402], 'such': [891, 1844, 3130, 3236, 3390], 'as': [892, 1164, 1224, 1226, 1298, 1332, 1401, 1461, 1812, 2184, 2186, 2485, 2540, 2542, 2937, 2939, 3209, 3315, 3378, 3629, 3635, 3681, 3683, 3924, 4011, 4013], 'melanoma,': [894], 'clear-cell': [895], 'carcinoma': [896], 'kidney,': [899], 'or': [900, 939, 1488, 2416, 3169, 3553, 3788, 3798, 4366, 4432], 'Reed-Sternberg': [901], "Hodgkin's": [904], 'lymphoma,': [905], 'where': [906, 4084], 'they': [907, 3513], 'diagnostic': [910], 'markers.': [911], 'Several': [912], 'objective': [913], 'semiquantitative': [915], 'analysis': [918, 1425, 2691, 2953, 3588], 'developed,': [922], 'been': [927, 4329], 'characterize': [930], 'organelle': [932], 'trait': [941], '(1-6).': [945], 'size': [947, 1102, 2365, 2743, 3853], 'several': [956, 1034, 1087, 2358, 3846], 'constituents': [957, 1159], 'much': [959, 2872], 'proliferating': [963, 988], 'than': [965, 990, 2347, 3164, 3330, 3979], 'quiescent': [968, 3904], 'counterparts.': [969], 'Thus,': [970, 4305], 'example,': [972, 4307], 'rRNA,': [976, 1012], 'nucleolus,': [981, 3129], 'many-fold': [983, 2462, 4413], 'higher': [984, 2463, 2673, 4414], 'resting': [993], 'cells,': [994, 3663, 3701, 3785, 3822, 3825, 4086], 'prior': [995], 'stimulation': [998, 1107, 2782, 2797, 2909, 2930, 3472, 3538, 3865, 3877], '(7).': [999, 2118], 'In': [1000, 1072, 1826, 1875, 2015, 2994, 3411], 'many': [1001, 3821], 'systems,': [1003], 'cellular': [1004, 1240, 1824, 3460, 3466, 3532, 3591, 4478], 'content,': [1006, 2566], 'which': [1008, 1863, 2303, 2360, 2655, 2979, 3005, 3392, 3731, 3763, 4031], 'over': [1009, 1859, 2521, 2623, 2880, 2990, 3965], '90%': [1010, 3464, 4475], 'strongly': [1013, 1050, 1280], 'kinetics': [1017], '(8),': [1018], 'variety': [1022], 'types,': [1025], 'prognosis': [1028], '(9).': [1029], 'Also,': [1030], 'amount': [1032], 'visualized': [1040], 'silver': [1042], 'staining': [1043, 2033, 2393], '(e.g.,': [1044], 'organizer': [1046], 'regions': [1047], 'proteins,': [1048], 'AgNORs)': [1049], 'activity': [1054, 1202, 4335], 'prognostic': [1057], 'value': [1058], 'oncology': [1060], '(10-16).': [1061], 'AgNORs': [1062], 'provide': [1064, 4458], 'machinery': [1066], 'ribosomal': [1068, 4268], 'gene': [1069], 'transcription': [1070], '(17).': [1071], 'study,': [1075], 'we': [1076, 3664], 'adapted': [1077], '(LSC),': [1082], 'instrument': [1084, 3374], 'combines': [1086], 'advantages': [1088], 'flow': [1090, 1440, 3584], 'image': [1092, 3343], '(18-22),': [1094], 'reveal': [1096, 2775], 'changes': [1098, 1124, 1255, 2777, 2788, 2903, 3458, 3476, 3844, 4100], 'during': [1105, 1464, 2780, 2929, 3470, 3492, 3521, 3537, 3676, 3684, 3758, 3863, 3893, 4103, 4497], 'mitogenic': [1106, 3471, 3864], 'polyvalent': [1112], 'mitogen': [1113], 'phytohemagglutinin': [1114, 1381], '(PHA).': [1115], 'This': [1116, 2098, 2241, 2754, 4118], 'model': [1118], 'allowed': [1119, 1209, 1934, 2980, 3006, 3393], 'us': [1120, 1210, 1935, 2981], 'associated': [1127, 4382], 'further': [1139], 'progression': [1140, 4130], 'cycle.': [1144, 3524, 4146], '(NCL),': [1149], 'previously': [1150], 'denoted': [1151], 'C23': [1152], '(23-28),': [1154], 'one': [1155], 'key': [1158, 3859], 'AgNORs,': [1161], 'organelles.': [1169], 'multifunctional': [1173], 'protein,': [1174], 'implicated': [1175], 'organization': [1178], 'chromatin,': [1181], 'packaging': [1184], 'pre-rRNA,': [1186], 'rDNA': [1187], 'transcription,': [1188, 4365], 'ribosome': [1190, 4367], 'assembly.': [1191], 'It': [1192, 1231, 2446, 2502, 3694], 'possesses': [1193], 'DNA': [1194, 1241, 1474, 1996, 2083, 2104, 2152, 2565, 2596, 2723, 3535, 3592, 3642, 3649, 3687, 3830], 'helicase': [1197, 4334], 'activities': [1198], 'DNA-dependent': [1200], 'ATP-ase': [1201], '(29-31).': [1203, 4369], 'capabilities': [1206, 4355], 'estimate': [1212, 1236, 2062, 3026, 3043], 'both': [1221, 2305, 2532, 4006], 'well': [1225, 2185, 2541, 2938, 3682, 4012], 'cytoplasm.': [1230, 2421], 'possible': [1234, 1849], 'area.': [1238, 3052], 'Because': [1239, 4215], 'measured': [1245, 1276, 1774, 1807, 2088, 2158, 2567, 2606, 2729, 2735, 3056, 3095, 3290, 3582, 3655, 3666, 3802, 4165], 'data': [1248, 1270, 1880, 2509, 3480], 'subjected': [1250, 1423, 2951, 3295], 'multivariate': [1252], 'morphometry': [1261, 2922], 'could': [1262, 3132], 'correlated': [1264], 'cell-cycle': [1267], 'position.': [1268], 'indicate': [1271], 'proliferation,': [1283], 'therefore': [1285, 2526], 'discriminate': [1290], 'noncycling': [1292], 'cycling': [1294, 4428, 4455], 'proliferative': [1302], 'potential': [1303], 'populations.': [1306], 'MATERIALS': [1307], 'AND': [1308], 'METHODS': [1309], 'Stimulation': [1310], 'Lymphocytes': [1312, 3543], 'peripheral': [1314], 'blood': [1315], 'lymphocytes,': [1316, 2310, 2440, 2698, 3151, 3729, 3867], 'obtained': [1317, 1500, 1629], 'venipuncture': [1319], 'healthy': [1321], 'volunteers': [1322], 'informed': [1324], 'consent,': [1325], 'isolated': [1327], 'density': [1329, 1368, 4046], 'gradient': [1330], 'centrifugation,': [1331, 1548], 'described': [1333, 1402, 1813, 2122, 3210, 3259, 3630], '(32).': [1334], 'washed': [1338, 1653], 'twice': [1339], 'phosphate-buffered': [1341], 'saline': [1342], '(PBS),': [1343], 'resuspended': [1344], 'RPMI-1640': [1346], 'medium': [1347, 1460, 1531], 'supplemented': [1348], '10%': [1350], 'fetal': [1351], 'bovine': [1352], 'serum': [1353], '(FBS),': [1354], '100': [1355, 1359, 1748], 'U/ml': [1356], 'penicillin,': [1358], 'μg/ml': [1360, 1735, 1749], 'streptomycin,': [1361], '2': [1363, 1487, 3795], 'mM': [1364], 'L-glutamine': [1365], '106': [1370], 'cells/ml,': [1371], 'treated': [1372, 1470, 1971, 2286, 3789, 4073], '10': [1374], 'μl': [1375], 'standard': [1378], 'solution': [1379], 'M,': [1382], 'incubated': [1384, 1679, 1711], '37.5°C': [1386], 'mixture': [1389], '95%': [1391], 'air': [1392], '5%': [1394], 'CO2': [1395], 'periods': [1398], 'time,': [1400, 2802, 4149], 'Results.': [1404], 'Parallel': [1405], 'samples': [1407, 1631], 'collected': [1409, 1869], '0,': [1411], '24,': [1412, 1540, 2945], '48,': [1413, 1541, 2946], '72': [1415, 1543, 1984, 2027, 2583, 2948, 3119, 3286, 4433], 'after': [1417, 2791, 3764, 3898, 4114], 'administration': [1418, 3899, 4115], 'PHA,': [1420, 1498, 3901], 'nuclei': [1430, 2457, 2557, 3672, 3752, 3782], 'LSC,': [1434, 2059, 2960, 3208, 3248], 'measurement': [1438, 2425], 'cytometry.': [1441, 3585], 'promyelocytic': [1443], 'leukemic': [1444, 3662], 'HL-60': [1445, 1514, 3674, 3703, 3746, 3754, 3784], '(obtained': [1447], 'American': [1450], 'Type': [1451], 'Culture': [1452], 'Collection,': [1453], 'Rockville,': [1454], 'MD)': [1455], 'cultured': [1457, 3545], 'above,': [1462, 3260], 'exponential': [1466, 3678], 'growth': [1467, 3679], 'phase': [1468, 2499, 3680], '150': [1472, 3791], 'nM': [1473, 3792], 'topoisomerase': [1475, 3688], 'I': [1476, 3689], 'inhibitor': [1477, 3690], 'camptothecin': [1478], '(CPT;': [1479], 'Sigma': [1480], 'Chemical': [1481, 1753], 'Co.,': [1482], 'St.': [1483], 'Louis,': [1484], 'MO)': [1485], '4': [1489, 3083, 3765, 3799, 3816], 'h.': [1490, 2195, 2901, 3120, 4061], 'All': [1491], 'tissue': [1492], 'culture': [1493, 1530, 2013, 2578, 3233], 'media': [1494], 'reagents,': [1496], 'Gibco/BRL': [1502], 'Life': [1503], 'Technologies,': [1504], '(Grand': [1506], 'Island,': [1507], 'NY).': [1508], 'Other': [1509], 'details': [1510], 'lymphocyte': [1512, 2781, 2908, 4503], 'culturing': [1515], 'provided': [1517], 'elsewhere': [1518, 2125, 3631], '(21,': [1519], '32).': [1520], 'Immunocytochemical': [1521], 'Detection': [1522], 'Nucleolin': [1524], 'Control': [1525], '(suspended': [1527], 'without': [1532], 'PHA)': [1533], 'PHA': [1538, 1973, 2021, 2192, 2288, 2581, 2943, 3115, 3227, 3282, 4058], 'sedimented': [1546], 'rinsed': [1549, 1707], 'PBS,': [1551, 1675, 1757], 'deposited': [1553], 'on': [1554, 1669, 1836, 2385, 2613, 2701, 2972, 3009, 3590, 4373, 4377], 'glass': [1555], 'slides': [1556, 1637, 1705], 'cytocentrifugation': [1558], '(Shandon,': [1559], 'Inc.,': [1560, 1691], 'Pittsburgh,': [1561], 'PA;': [1562], '1,000': [1563], 'rpm,': [1564], '6': [1565], 'min,': [1566, 1599], 'room': [1567, 1723, 1762], 'temperature).': [1568], 'Slides': [1569], 'fixed': [1571, 1632], 'immersing': [1573], 'them': [1574, 3370], 'Coplin': [1577], 'jar': [1578], 'filled': [1579], 'fixative:': [1581], 'three': [1582, 3157], 'fixative': [1584], 'protocols': [1585], 'tested:': [1587], '80%': [1588, 1602], 'ethanol': [1589], '(−20°C),': [1590, 1593], '100%': [1591], 'methanol': [1592], 'formaldehyde': [1595], '(4%)': [1596], '15': [1598], 'followed': [1600, 4134], 'ethanol.': [1603, 1635], 'No': [1604], 'significant': [1605, 2371], 'differences': [1606, 3499, 4438], 'detection': [1609, 3263], 'antibody': [1612, 1715], 'noticed': [1614, 4102], 'fixatives.': [1617], 'For': [1618], 'consistency,': [1619], 'results': [1621, 2771], 'illustrations': [1623], 'presented': [1624, 2071, 2510], 'cold': [1634], 'kept': [1639], 'alcohol': [1641], 'least': [1644, 3304], '−20°C.': [1648], 'After': [1649, 3815], 'fixation,': [1650], 'specimens': [1651, 2248, 3274], 'PBS': [1655, 1709], '(twice': [1656], '5': [1658, 1667, 1734], 'min)': [1659], 'immersed': [1661], '0.1%': [1663], 'Triton': [1664], 'X-100': [1665], 'min': [1668, 1760], 'ice.': [1670], 'Following': [1671], 'wash': [1673], 'anti-nucleolar': [1682], 'antibody,': [1683], '(catalog': [1685], 'no.': [1686], 'sc-8031,': [1687], 'Santa': [1688, 1692], 'Cruz': [1689], 'Biotechnology,': [1690], 'Cruz,': [1693], 'CA),': [1694, 1719], 'diluted': [1695, 1720], '1:20': [1696, 1721], '4°C': [1698], 'overnight': [1699], 'humidified': [1702], 'chamber.': [1703], 'Then': [1704], 'FITC-conjugated': [1713], 'anti-mouse': [1714], '(DAKO': [1716], 'Corp.,': [1717, 1782], 'Carpinteria,': [1718], 'temperature': [1724, 1763], '30': [1726, 1759], 'min.': [1727], 'Finally,': [1728], 'counterstained': [1732, 1998, 2252, 2598], 'propidium': [1737], 'iodide': [1738], '(PI;': [1739], 'Molecular': [1740, 2096], 'Probes,': [1741], 'Eugene,': [1742], 'OR)': [1743], 'presence': [1746, 3554], 'RNase': [1750, 3615], 'A': [1751, 2468, 2676, 2844, 2883], '(Sigma': [1752], 'Co.),': [1754], 'dissolved': [1755], 'dark.': [1766], 'Fluorescence': [1767], 'Measurement': [1768, 2078], 'Cellular': [1771, 2082, 2603, 3648, 3829], 'fluorescence': [1772, 1805, 1838, 1868, 1909, 2008, 2139, 2411, 2434, 2604, 2615, 2635, 2974, 3267, 3365, 3602, 3621], 'use': [1776], 'multiparameter': [1779], '(CompuCyte': [1781], 'Cambridge,': [1783], 'MA)': [1784], '(18-22).': [1785], 'Cells': [1786, 3558, 3639], 'illuminated': [1788], '488-nm-wavelength': [1791], 'argon': [1792], 'ion': [1793], 'green': [1796, 1855, 1906, 2130, 2381, 2985, 3364, 3569], '(530': [1797, 2131], '±': [1798, 2132], '20': [1799, 2133], 'nm),': [1800], 'red': [1802, 1837, 2136, 2614, 2634, 2669, 2705, 2973, 3567, 3601, 3620], '(>610': [1803], 'nm)': [1804, 2134, 2138], 'separate': [1810], 'photomultipliers,': [1811], '(20-22).': [1814], 'Two': [1815], 'strategies': [1817], 'used,': [1819, 3004], 'often': [1820, 2362], 'sequentially,': [1821], 'fluorescence.': [1825, 3410], 'approach,': [1829, 1878], 'integration': [1831, 2967], 'contour': [1832, 2610, 2968], 'set': [1834, 2612, 2970], 'based': [1835, 2700, 2971, 3008, 3589], 'PI': [1840, 2433, 2600, 2976], '(nuclear': [1841, 2977], 'outline).': [1842], 'With': [1843], 'setting': [1846], 'integrate': [1851, 2067, 2983], 'intensity': [1853, 1942, 2515, 3010, 3032, 3362, 3599, 3622], 'immunofluorescence': [1856, 1945, 2258, 2518, 2620, 2747, 2878, 2893, 2986, 3035, 3049, 3197, 4028], 'whole': [1861, 2523, 2625, 2881, 2992, 4168], 'represented': [1864], 'sum': [1866, 2530], 'nucleoplasm.': [1874, 2038, 2240, 2545, 4214, 4257, 4400], 'second': [1877, 2996], 'acquired': [1882], '"FISH': [1887, 1922], 'application,"': [1888], 'integral': [1890], 'part': [1891], 'WinCyte': [1893, 1900], 'software': [1894, 2759, 3000], '(18,': [1897], '19).': [1898], 'Briefly,': [1899], 'searched': [1901], 'probes': [1907, 3257], '(green': [1908, 2591], 'NCL)': [1911], 'boundaries': [1914], '(red': [1915, 2601], 'fluorescence,': [1916, 2069, 2382, 2592, 3570], 'DNA;': [1917], 'see': [1918], 'Fig.': [1919], '1E,F).': [1920, 2769], 'application"': [1923], 'revealed': [1926, 3344], 'integrated': [1946, 2520, 2622, 2879, 3036, 3047], 'only': [1947, 2751, 3037, 3944, 4171], 'nucleoli.': [1950, 2753, 3097, 3171, 4294], 'Figure': [1951, 2169, 2444, 2512, 2546, 2915, 3082, 3172, 3525, 3771], '1Open': [1952], 'figure': [1954, 2549, 2918, 3175, 3528, 3774], 'viewerPowerPoint': [1955, 2550, 2919, 3176, 3529, 3775], 'Localization': [1956], 'nonstimulated': [1960, 2182, 2197, 2306, 2353, 2437, 2466, 2560, 2640, 2719, 3124, 3203], 'PHA-stimulated': [1962, 2301, 2342, 2439, 2562, 2687, 2693, 3150, 3205], 'lymphocytes.': [1963, 2688, 2932, 3081], 'Nonstimulated': [1964, 2570, 2933], '(A)': [1966, 3552, 3787], 'cultures': [1970, 2285, 2343, 2720, 3112, 3279], '(B,': [1977, 2731], 'E,': [1978], 'F),': [1979], '48': [1980, 2023, 3117, 3284, 3547, 4203, 4431], '(C),': [1982, 3801], '(D)': [1986, 2029], 'stained': [1988, 3562], 'anti-NCL': [1990, 2277], 'Ab': [1991, 2278], '(FITC': [1992], 'fluorescence),': [1993], 'PI.': [2000], 'Note': [2001, 2680, 3805], 'strong': [2002, 2379, 2391], 'weak': [2005], 'nucleoplasmic': [2006], '24-h': [2012, 3149, 3232], '(B).': [2014, 2721], 'contrast,': [2016], '(C)': [2025], 'show': [2030, 2041, 3234, 3481], 'intense': [2032], '(yellow': [2034], 'hue)': [2035], 'Mitotic': [2039], 'cytoplasmic': [2042, 2380, 2392, 2410], 'localization': [2043, 4186], 'peripheries': [2050], '(C,': [2051, 2585], 'D).': [2052], 'principle': [2054], 'FISH': [2056, 2766, 2999, 3256], 'contouring': [2057, 3386, 3402, 3416], 'E': [2073], 'F.': [2075], 'Content': [2077], 'Flow': [2080], 'metachromatic': [2091], 'fluorochrome': [2092], 'acridine': [2093], 'orange': [2094], '(AO;': [2095], 'Probes).': [2097], 'dye': [2099], 'differentially': [2100], 'stains': [2101], 'virtue': [2106], 'affinities': [2109], 'modes': [2111], 'binding': [2113], 'nucleic': [2116], 'acids': [2117], 'method': [2120], 'detail': [2124], '(33).': [2126], 'Intensity': [2127], '(>640': [2137], 'induced': [2140], 'excitation': [2142], '488': [2144], 'nm,': [2145], 'representing': [2147, 3571], 'interaction': [2148], 'AO': [2150, 3564, 3572], 'RNA,': [2154], 'respectively': [2155, 3578], '(7),': [2156], 'FACScan': [2161], '(Becton': [2163], 'Dickinson,': [2164], 'San': [2165], 'Jose,': [2166], 'CA).': [2167], 'RESULTS': [2168], '1': [2170], 'illustrates': [2171, 3084], 'typical': [2173], 'pattern': [2174], 'intracellular': [2176], 'distribution': [2177], '24–72': [2194], 'Most': [2196, 2327], 'showed': [2199, 2257, 2320, 2377], 'single,': [2201], 'occasionally': [2203], 'two': [2204, 2962, 3170, 3299, 4272], 'small': [2205, 2328, 2339, 2651], 'expressing': [2207], 'NCL.': [2208, 3191, 3719, 3984], 'yellowish': [2210], 'hue': [2211], 'reflects': [2217], 'colocalization': [2219], 'FITC': [2221], 'PI,': [2223], 'indicates': [2225], 'expressed,': [2230], 'although': [2231], 'lower': [2234, 2873, 3161], 'density,': [2235], 'outside': [2236, 4210], 'confirmed': [2243], 'microscopy': [2245, 3297], 'not': [2251, 2495, 3133, 3735, 3740], 'PI;': [2254, 2617], 'addition': [2262], 'stronger': [2265], 'labeling': [2266], '(not': [2269], 'shown).': [2270], 'strongest': [2272], 'stainability': [2273], 'demonstrated': [2280], '(Fig.': [2292, 2400, 2500, 2768, 2783, 2913, 3477, 3692, 3709, 3884, 4038, 4175], '1B).': [2293], '48-h': [2298, 3224], '72-h': [2300, 3226], 'cultures,': [2302, 3228], 'contained': [2304], '(G0)': [2307], 'latter': [2312], 'phases': [2315], 'diverse': [2322], 'patterns': [2323], 'expression.': [2326], 'had': [2330, 2357, 3126, 3159, 3407], 'single': [2332, 3128, 3168, 3380], 'prominent': [2346], 'cultures.': [2354, 3836], 'Larger': [2355], 'large': [2364], 'irregular': [2367], 'shape.': [2368], 'Interestingly,': [2369, 2863], 'percentage': [2372], 'large-size': [2374], '(>30%)': [2376], 'localized': [2384, 2750, 3999, 4198], 'periphery.': [2388], 'common': [2395], 'all': [2397, 3123, 3518, 3878, 4091], 'mitotic': [2398], '1B,C),': [2401], 'interphase': [2403], 'displayed': [2406], 'pattern.': [2408], 'either': [2413], 'irregular,': [2414], '"patchy,"': [2415], 'relatively': [2417, 3510, 4219], 'uniform': [2418, 3713], 'throughout': [2419], 'immunofluorescence,': [2428], 'combined': [2429], 'DNA-associated': [2432], 'shown': [2442, 4330], '2.': [2445], 'quite': [2448, 3696], 'evident': [2449, 3697], 'compared': [2464, 3427, 3706, 3933, 4425], 'well-defined': [2469], 'threshold': [2470, 2493, 3387, 3417, 3722], 'apparent': [2479, 2898, 3220, 3741], 'G0/1': [2482], 'population,': [2484, 3705], 'did': [2494, 3734], 'enter': [2496, 3736], 'S': [2498, 3737, 4239], '2D).': [2501], 'should': [2503], 'stressed': [2505], '2,': [2513], 'represents': [2528, 3072], 'resides': [2536], '2Open': [2547], 'Expression': [2551, 3748, 3776], 'versus': [2564, 2636, 4453], 'LSC.': [2569, 2608, 3804], '(A,': [2572], 'B)': [2573], 'D)': [2586, 2732], 'immunostained': [2588], 'FITC),': [2593], 'fluorescence).': [2602], 'Threshold': [2609], 'hence,': [2618], 'On': [2627], 'bivariate': [2628], 'distributions': [2629], 'maximal': [2631, 2648, 2670, 2704, 3887, 4490], 'pixels': [2632, 2671], '(G0': [2642], 'cells)': [2643], 'characterized': [2645], 'pixel': [2649], 'values,': [2654], 'reflect': [2656], 'condensed': [2658], 'chromatin': [2662, 4360], '(48).': [2663, 2679], 'few': [2665], 'low': [2668], 'represent': [2677], 'monocytes': [2678], 'marked': [2681, 2776], 'increase': [2682, 3076, 3383, 3487, 3890, 3914, 3938, 3954, 3967, 3981, 4022, 4034, 4494], 'paint-a-gate': [2690], 'shows': [2695], 'selected': [2699], 'pixels,': [2706], 'minimal': [2708], '(D),': [2712], 'similar': [2713], 'Insets:': [2722, 3647, 3828], 'histograms': [2726, 3652, 3833], 'We': [2733, 3238, 3453], '(area),': [2744, 3854], 'accomplished': [2756], 'originally': [2762], 'designed': [2763, 3252], '(18)': [2767, 3258], 'measurements': [2774], '3).': [2784, 2914, 3885, 4176], 'most': [2786, 3912, 4096, 4178, 4286], 'dramatic': [2787], 'observed': [2790, 3104, 3145, 3892, 4021, 4394], 'initial': [2793], 'PHA.': [2799, 3542, 3557, 4117], 'At': [2800], 'contents': [2807], '8-': [2812], 'respectively,': [2815], 'larger': [2820], 'ratio': [2825, 2890, 3045, 4025], 'elevated': [2833, 3931], '4-fold,': [2835], 'mean': [2838, 3598], 'almost': [2842, 4161], 'doubled.': [2843], 'dramatic,': [2846], 'decrease': [2849, 2875, 2884, 3807], 'seen': [2857, 4496], 'stimulation.': [2862, 4436], 'same': [2867, 3273, 3312], '(<25%)': [2874], 'nuclei.': [2882], '48–72': [2905], 'less': [2911, 3978], '3Open': [2916], 'Changes': [2920, 3053, 3530], '(0': [2935, 3063], 'h)': [2936], 'approaches.': [2964], 'First,': [2965], 'outline),': [2978], 'run,': [2997], 'us,': [3007], 'immunofluorescence;': [3013], 'to:': [3014], '1)': [3015], 'detect': [3016], 'count': [3020, 3254, 3420], 'nucleus;': [3024], '2)': [3025], 'area;': [3028], '3)': [3029], 'nucleoli;': [3040], '4)': [3042], 'normalized': [3059], 'untreated': [3061, 3786], '=': [3065], '1.0),': [3066], 'so': [3067], 'ordinate': [3070], 'scale': [3071], 'relative': [3074, 3995], 'n-fold': [3075], 'respect': [3078], 'relationship': [3086], 'As': [3098, 3871], 'expected,': [3099, 3872], 'positive': [3101, 3217], 'correlation': [3102, 3143, 3180, 3218], 'case': [3107, 3744], 'Since': [3121], 'correlations': [3131], '0-h': [3138], 'samples.': [3139], 'Surprisingly,': [3140], 'no': [3142, 3235], 'actually': [3153], '4Open': [3173], 'Analysis': [3177], 'Number': [3192], 'Methods.': [3214], 'correlation.': [3237], 'attempted': [3239], 'strategy': [3251], '"by': [3264], 'eye"': [3265], 'under': [3266], 'microscopy.': [3268, 3332], 'Towards': [3269], 'end,': [3271], 'then': [3294, 3560], 'individuals,': [3300], 'each': [3301, 3358, 3624], 'counting': [3302], '500': [3305], 'specimen': [3308], 'optical': [3313], 'magnification': [3314], '(40×': [3317], 'objective).': [3318], 'Under': [3319], 'conditions,': [3321], 'approximately': [3322, 4173], '50%': [3323], 'fewer': [3324], 'Relocation': [3333], 'examination': [3340], 'instances': [3348], 'close': [3355], 'proximity': [3356], 'substantial,': [3372], 'contoured': [3375], 'An': [3382], 'situations,': [3391], 'separation': [3394], 'led': [3397, 3767], 'loss': [3400], 'weaker': [3408], 'consequence,': [3412], 'regardless': [3413], 'setting,': [3418], 'underestimated': [3426], 'visual': [3430], 'examination.': [3431], 'Ribosomal': [3432], 'main': [3436], 'synthesized': [3438], 'organelle.': [3452], 'attempted,': [3454], 'therefore,': [3455, 3993], 'compare': [3457, 3658], '(over': [3463, 4474], 'rRNA)': [3469, 4481], '5).': [3478], 'greatest,': [3484], '8-fold': [3486, 3966], 'occurs': [3491], 'G1.': [3497, 3910], 'G1,': [3504, 3607, 3992, 4233], 'G2/M': [3507, 3610], 'minor,': [3511], 'reflected': [3514], 'doubling': [3516], 'components': [3520], '5Open': [3526], 'absence': [3551], '(B)': [3555, 3797], 'interactions': [3573], 'DNA,': [3577], '(7,': [3579], '33),': [3580], 'By': [3586], 'gating': [3587], '(cell': [3594], 'position),': [3596], 'G0,': [3606], 'subpopulations.': [3612], 'C:': [3613], 'Mean': [3614], 'component': [3617], 'subpopulations,': [3627], '(33),': [3632], 'plotted': [3634], 'bar': [3637], 'graph.': [3638], 'fractional': [3641], 'apoptotic': [3645], '(Ap).': [3646], 'To': [3657], 'normal': [3659], 'treatment': [3685, 3760, 3820], 'CPT': [3691, 3793], '6).': [3693], 'lacking': [3699], '2D),': [3710], 'terms': [3715, 4009], 'characteristic': [3721], 'phase,': [3738, 4133], 'reduced': [3757], 'CPT,': [3762], 'apoptosis.': [3770, 3827], '6Open': [3772], 'CPT-treated': [3813], 'predominantly': [3823, 4199], 'S-phase': [3824], 'DISCUSSION': [3837], 'adaptation': [3839], 'yielded': [3868], 'interesting': [3869, 4099], 'findings.': [3870], 'course': [3875, 4508], 'upregulated': [3883], 'i.e.,': [3902, 4505], 'CLN': [3919], 'compartment,': [3923], '12-fold': [3932], '3-fold.': [3945], 'Assuming': [3946], 'sphere,': [3951, 4068], '3-fold': [3953], '(projected': [3957], 'section': [3958], 'equator)': [3961], 'translates': [3962], 'volume.': [3969], 'volume': [3972, 4018], 'increase,': [3973], 'thus,': [3974], 'about': [3976], '30%': [3977, 4174], 'absolute': [4008], '(12-fold),': [4010], 'unit': [4015], '(∼30%).': [4019], '/nucleolar': [4029], 'exceeded': [4032], '3),': [4039], 'additionally': [4040], 'supports': [4041], 'contention': [4043], 'assumption': [4063], 'has': [4070, 4328], 'cautiously,': [4074], 'especially': [4075], 'preparations': [4078], 'made': [4081], 'cytocentrifugation,': [4083], 'nuclei,': [4088], 'flattened.': [4094], 'unexpected': [4097], 'namely': [4110], 'interval': [4120], 'coincided': [4121], 'entrance': [4124], 'traverse': [4136], 'division,': [4138], 'reentrance': [4140], 'while': [4150, 4191, 4337], 'dropped': [4160], '6-fold,': [4162], 'decreased': [4170], 'plausible': [4179], 'explanation': [4180], 'disparity': [4183], 'altered:': [4190], 'abundant': [4209], 'stable': [4220], '(29-31),': [4222], 'observation': [4224], 'suggests': [4225], 'following': [4227], 'entering': [4238], 'Binding': [4258], 'subset': [4266], 'recognition': [4274], 'motifs': [4275], 'glycine-rich': [4278], 'domain': [4279], 'carboxyl-terminal': [4282], 'region': [4283], '(34-36)': [4284], 'likely': [4287], 'responsible': [4288, 4391], 'known': [4297], 'shuttle': [4299], 'compartments': [4303], '(30).': [4304], 'transfers': [4309], 'signals': [4310], 'surface,': [4314], 'cytoplasm,': [4316], 'Phosphorylation': [4320, 4370], 'CKII': [4324], 'cdc2': [4326, 4341, 4378], 'kinase': [4327, 4350], 'regulate': [4332, 4352], '(37),': [4336], 'phosphorylation': [4338], 'CKII,': [4340], 'kinase,': [4342, 4347], 'PKC-N,': [4343], 'cyclic': [4344], 'AMP-dependent': [4345], 'ecto-protein': [4349], 'organization,': [4361], 'packaging,': [4363], 'assembly': [4368], 'sites,': [4375, 4379], 'particularly': [4376], '(38-40),': [4387], 'One': [4401], 'ask': [4403], 'why': [4404], 'undergoing': [4418], 'traversing': [4448], 'clue': [4460], 'explaining': [4465], 'observation.': [4467], 'Namely,': [4468], 'total': [4472, 4477], 'low,': [4487], 'G': [4512]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1969296663', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-08T23:47:53.569978', 'created_date': '2016-06-24'}
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