Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1969213969', 'doi': 'https://doi.org/10.1038/sj.leu.2402447', 'title': 'Development of gene therapy for hematopoietic stem cells using lentiviral vectors', 'display_name': 'Development of gene therapy for hematopoietic stem cells using lentiviral vectors', 'publication_year': 2002, 'publication_date': '2002-04-01', 'ids': {'openalex': 'https://openalex.org/W1969213969', 'doi': 'https://doi.org/10.1038/sj.leu.2402447', 'mag': '1969213969', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11960333'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/sj.leu.2402447', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S149476849', 'display_name': 'Leukemia', 'issn_l': '0887-6924', 'issn': ['0887-6924', '1476-5551'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1038/sj.leu.2402447', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5054051519', 'display_name': 'Niels-Bjarne Woods', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I187531555', 'display_name': 'Lund University', 'ror': 'https://ror.org/012a77v79', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I187531555']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'N-B Woods', 'raw_affiliation_strings': ['Molecular Medicine and Gene Therapy, Lund University Hospital, Lund, Sweden.'], 'affiliations': [{'raw_affiliation_string': 'Molecular Medicine and Gene Therapy, Lund University Hospital, Lund, Sweden.', 'institution_ids': ['https://openalex.org/I187531555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5035744613', 'display_name': 'Andreas Ooka', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I187531555', 'display_name': 'Lund University', 'ror': 'https://ror.org/012a77v79', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I187531555']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'A Ooka', 'raw_affiliation_strings': ['Molecular Medicine and Gene Therapy, Lund University Hospital, Lund, Sweden.'], 'affiliations': [{'raw_affiliation_string': 'Molecular Medicine and Gene Therapy, Lund University Hospital, Lund, Sweden.', 'institution_ids': ['https://openalex.org/I187531555']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5103149289', 'display_name': 'Stefan Karlsson', 'orcid': 'https://orcid.org/0000-0002-2353-2531'}, 'institutions': [{'id': 'https://openalex.org/I187531555', 'display_name': 'Lund University', 'ror': 'https://ror.org/012a77v79', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I187531555']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'S Karlsson', 'raw_affiliation_strings': ['Molecular Medicine and Gene Therapy, Lund University Hospital, Lund, Sweden.'], 'affiliations': [{'raw_affiliation_string': 'Molecular Medicine and Gene Therapy, Lund University Hospital, Lund, Sweden.', 'institution_ids': ['https://openalex.org/I187531555']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3890, 'currency': 'EUR', 'value_usd': 4790, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.765, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 41, 'citation_normalized_percentile': {'value': 0.617362, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '16', 'issue': '4', 'first_page': '563', 'last_page': '569'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10613', 'display_name': 'Gene Therapy Techniques and Applications', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10613', 'display_name': 'Gene Therapy Techniques and Applications', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10878', 'display_name': 'Clustered Regularly Interspaced Short Palindromic Repeats and CRISPR-associated proteins', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10725', 'display_name': 'Mechanisms and Applications of RNA Interference', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lentiviral-vector', 'display_name': 'Lentiviral Vector', 'score': 0.588006}, {'id': 'https://openalex.org/keywords/gene-therapy', 'display_name': 'Gene Therapy', 'score': 0.519549}, {'id': 'https://openalex.org/keywords/hematopoietic-stem-cell', 'display_name': 'Hematopoietic stem cell', 'score': 0.43126908}, {'id': 'https://openalex.org/keywords/transduction', 'display_name': 'Transduction (biophysics)', 'score': 0.4301401}], 'concepts': [{'id': 'https://openalex.org/C111599444', 'wikidata': 'https://www.wikidata.org/wiki/Q213901', 'display_name': 'Genetic enhancement', 'level': 3, 'score': 0.8511722}, {'id': 'https://openalex.org/C32470452', 'wikidata': 'https://www.wikidata.org/wiki/Q2298489', 'display_name': 'Viral vector', 'level': 4, 'score': 0.7011053}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.6919388}, {'id': 'https://openalex.org/C109159458', 'wikidata': 'https://www.wikidata.org/wiki/Q919283', 'display_name': 'Haematopoiesis', 'level': 3, 'score': 0.67476624}, {'id': 'https://openalex.org/C102230213', 'wikidata': 'https://www.wikidata.org/wiki/Q430117', 'display_name': 'Transgene', 'level': 3, 'score': 0.66763496}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6096456}, {'id': 'https://openalex.org/C43953973', 'wikidata': 'https://www.wikidata.org/wiki/Q7917858', 'display_name': 'Vectors in gene therapy', 'level': 5, 'score': 0.5638238}, {'id': 'https://openalex.org/C92087593', 'wikidata': 'https://www.wikidata.org/wiki/Q427389', 'display_name': 'Vector (molecular biology)', 'level': 4, 'score': 0.51684386}, {'id': 'https://openalex.org/C135983454', 'wikidata': 'https://www.wikidata.org/wiki/Q2790163', 'display_name': 'Gene delivery', 'level': 4, 'score': 0.51267326}, {'id': 'https://openalex.org/C2778086970', 'wikidata': 'https://www.wikidata.org/wiki/Q514525', 'display_name': 'Hematopoietic stem cell', 'level': 4, 'score': 0.43126908}, {'id': 'https://openalex.org/C15152581', 'wikidata': 'https://www.wikidata.org/wiki/Q7833966', 'display_name': 'Transduction (biophysics)', 'level': 2, 'score': 0.4301401}, {'id': 'https://openalex.org/C2779690655', 'wikidata': 'https://www.wikidata.org/wiki/Q374232', 'display_name': 'Lentivirus', 'level': 4, 'score': 0.4233968}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.371467}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.3334778}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.2699608}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.22926787}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.19746152}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.12140441}, {'id': 'https://openalex.org/C40767141', 'wikidata': 'https://www.wikidata.org/wiki/Q285697', 'display_name': 'Recombinant DNA', 'level': 3, 'score': 0.07728654}, {'id': 'https://openalex.org/C2780727368', 'wikidata': 'https://www.wikidata.org/wiki/Q1928978', 'display_name': 'Viral disease', 'level': 3, 'score': 0.04951331}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D015316', 'descriptor_name': 'Genetic Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D006412', 'descriptor_name': 'Hematopoietic Stem Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016086', 'descriptor_name': 'Lentivirus', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D007938', 'descriptor_name': 'Leukemia', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005822', 'descriptor_name': 'Genetic Vectors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006412', 'descriptor_name': 'Hematopoietic Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016086', 'descriptor_name': 'Lentivirus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007938', 'descriptor_name': 'Leukemia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007938', 'descriptor_name': 'Leukemia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/sj.leu.2402447', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S149476849', 'display_name': 'Leukemia', 'issn_l': '0887-6924', 'issn': ['0887-6924', '1476-5551'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://lup.lub.lu.se/record/465036', 'pdf_url': 'https://lup.lub.lu.se/search/files/5484981/1692947.pdf', 'source': {'id': 'https://openalex.org/S4306400536', 'display_name': 'Lund University Publications (Lund University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I187531555', 'host_organization_name': 'Lund University', 'host_organization_lineage': ['https://openalex.org/I187531555'], 'host_organization_lineage_names': ['Lund University'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://portal.research.lu.se/files/5484981/1692947.pdf', 'pdf_url': 'https://portal.research.lu.se/files/5484981/1692947.pdf', 'source': {'id': 'https://openalex.org/S4306400536', 'display_name': 'Lund University Publications (Lund University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I187531555', 'host_organization_name': 'Lund University', 'host_organization_lineage': ['https://openalex.org/I187531555'], 'host_organization_lineage_names': ['Lund University'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11960333', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/sj.leu.2402447', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S149476849', 'display_name': 'Leukemia', 'issn_l': '0887-6924', 'issn': ['0887-6924', '1476-5551'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 344, 'referenced_works': ['https://openalex.org/W1042356266', 'https://openalex.org/W108816917', 'https://openalex.org/W112079687', 'https://openalex.org/W126044765', 'https://openalex.org/W127246327', 'https://openalex.org/W1277925548', 'https://openalex.org/W135317861', 'https://openalex.org/W1483929886', 'https://openalex.org/W1484778901', 'https://openalex.org/W1485241032', 'https://openalex.org/W1487837935', 'https://openalex.org/W1494707213', 'https://openalex.org/W1495020242', 'https://openalex.org/W1504115723', 'https://openalex.org/W1511525349', 'https://openalex.org/W1512478116', 'https://openalex.org/W1514456452', 'https://openalex.org/W1542326554', 'https://openalex.org/W1544190956', 'https://openalex.org/W1551102474', 'https://openalex.org/W1560247773', 'https://openalex.org/W1563402441', 'https://openalex.org/W1563666839', 'https://openalex.org/W1566969252', 'https://openalex.org/W1579215839', 'https://openalex.org/W1582643093', 'https://openalex.org/W1583089733', 'https://openalex.org/W1587940136', 'https://openalex.org/W1589194933', 'https://openalex.org/W1591189766', 'https://openalex.org/W1594848307', 'https://openalex.org/W1596473475', 'https://openalex.org/W1602106002', 'https://openalex.org/W1606535746', 'https://openalex.org/W1608762409', 'https://openalex.org/W1631250427', 'https://openalex.org/W1691610911', 'https://openalex.org/W1750539994', 'https://openalex.org/W1759752688', 'https://openalex.org/W1769569140', 'https://openalex.org/W177057739', 'https://openalex.org/W1786249782', 'https://openalex.org/W1789346125', 'https://openalex.org/W180715220', 'https://openalex.org/W1816761971', 'https://openalex.org/W1818877461', 'https://openalex.org/W1835972708', 'https://openalex.org/W1844096607', 'https://openalex.org/W1852665292', 'https://openalex.org/W1865496775', 'https://openalex.org/W1900762885', 'https://openalex.org/W1908410208', 'https://openalex.org/W1909729402', 'https://openalex.org/W1925667723', 'https://openalex.org/W1953437662', 'https://openalex.org/W1953643054', 'https://openalex.org/W1966482743', 'https://openalex.org/W1969219224', 'https://openalex.org/W1971384581', 'https://openalex.org/W1976430696', 'https://openalex.org/W1976661899', 'https://openalex.org/W1977708103', 'https://openalex.org/W1978477460', 'https://openalex.org/W1981088384', 'https://openalex.org/W1981441452', 'https://openalex.org/W1981916489', 'https://openalex.org/W1982537658', 'https://openalex.org/W1982765182', 'https://openalex.org/W1984800697', 'https://openalex.org/W1985128235', 'https://openalex.org/W1985313226', 'https://openalex.org/W1987483457', 'https://openalex.org/W1988614032', 'https://openalex.org/W1988858610', 'https://openalex.org/W1990888754', 'https://openalex.org/W1991555921', 'https://openalex.org/W1991664409', 'https://openalex.org/W1991851022', 'https://openalex.org/W1992525863', 'https://openalex.org/W1993702378', 'https://openalex.org/W1995004137', 'https://openalex.org/W1995303015', 'https://openalex.org/W1995365460', 'https://openalex.org/W1997170085', 'https://openalex.org/W1997874790', 'https://openalex.org/W2000284725', 'https://openalex.org/W2000925826', 'https://openalex.org/W2001243226', 'https://openalex.org/W2001855651', 'https://openalex.org/W2002097645', 'https://openalex.org/W2003868334', 'https://openalex.org/W2006351633', 'https://openalex.org/W2006402322', 'https://openalex.org/W2006448209', 'https://openalex.org/W2006519535', 'https://openalex.org/W2006765654', 'https://openalex.org/W2007743725', 'https://openalex.org/W2008512248', 'https://openalex.org/W2009761723', 'https://openalex.org/W2010056602', 'https://openalex.org/W2010319708', 'https://openalex.org/W2010863271', 'https://openalex.org/W2011767474', 'https://openalex.org/W2013908437', 'https://openalex.org/W2016191371', 'https://openalex.org/W2017032718', 'https://openalex.org/W2018357983', 'https://openalex.org/W2020115934', 'https://openalex.org/W2021444597', 'https://openalex.org/W2021550815', 'https://openalex.org/W2021923391', 'https://openalex.org/W2022989605', 'https://openalex.org/W2023691501', 'https://openalex.org/W2024577717', 'https://openalex.org/W2024886013', 'https://openalex.org/W2025101131', 'https://openalex.org/W2025690693', 'https://openalex.org/W2025799190', 'https://openalex.org/W2026473142', 'https://openalex.org/W2026773700', 'https://openalex.org/W2027122999', 'https://openalex.org/W2027321452', 'https://openalex.org/W2027927113', 'https://openalex.org/W2028196271', 'https://openalex.org/W2028418295', 'https://openalex.org/W2030220702', 'https://openalex.org/W2031215518', 'https://openalex.org/W2032579724', 'https://openalex.org/W2032594449', 'https://openalex.org/W2033217413', 'https://openalex.org/W2033653831', 'https://openalex.org/W2035444138', 'https://openalex.org/W2035760584', 'https://openalex.org/W2035970395', 'https://openalex.org/W2036300762', 'https://openalex.org/W2037174767', 'https://openalex.org/W2037585283', 'https://openalex.org/W2039028257', 'https://openalex.org/W2039939454', 'https://openalex.org/W2040770363', 'https://openalex.org/W2040827928', 'https://openalex.org/W2041232976', 'https://openalex.org/W2041695960', 'https://openalex.org/W2042021736', 'https://openalex.org/W2043173210', 'https://openalex.org/W2044569441', 'https://openalex.org/W2045899482', 'https://openalex.org/W2046992485', 'https://openalex.org/W2047028501', 'https://openalex.org/W2047227694', 'https://openalex.org/W2048574196', 'https://openalex.org/W2050423350', 'https://openalex.org/W2052150955', 'https://openalex.org/W2052337124', 'https://openalex.org/W205272249', 'https://openalex.org/W2054031422', 'https://openalex.org/W2054131802', 'https://openalex.org/W2056359927', 'https://openalex.org/W2058092842', 'https://openalex.org/W2058875293', 'https://openalex.org/W2059003079', 'https://openalex.org/W2059365987', 'https://openalex.org/W2059969433', 'https://openalex.org/W2063486944', 'https://openalex.org/W2064496329', 'https://openalex.org/W2065409713', 'https://openalex.org/W2065786458', 'https://openalex.org/W2066554543', 'https://openalex.org/W2066772650', 'https://openalex.org/W2067379696', 'https://openalex.org/W2067576243', 'https://openalex.org/W2069519855', 'https://openalex.org/W2071460884', 'https://openalex.org/W2073905027', 'https://openalex.org/W2075436180', 'https://openalex.org/W2075932312', 'https://openalex.org/W2076088666', 'https://openalex.org/W2076355219', 'https://openalex.org/W2076770967', 'https://openalex.org/W2077127071', 'https://openalex.org/W2077649301', 'https://openalex.org/W2077697398', 'https://openalex.org/W2080366675', 'https://openalex.org/W2080589169', 'https://openalex.org/W2083150665', 'https://openalex.org/W2083458978', 'https://openalex.org/W2083459784', 'https://openalex.org/W2083632015', 'https://openalex.org/W2084627994', 'https://openalex.org/W2085579435', 'https://openalex.org/W2086943348', 'https://openalex.org/W2087427344', 'https://openalex.org/W2087508782', 'https://openalex.org/W2087809591', 'https://openalex.org/W2088171363', 'https://openalex.org/W2088438660', 'https://openalex.org/W2088561765', 'https://openalex.org/W2088583545', 'https://openalex.org/W2088820141', 'https://openalex.org/W2088851522', 'https://openalex.org/W2089710389', 'https://openalex.org/W2089894429', 'https://openalex.org/W2090429649', 'https://openalex.org/W2091757239', 'https://openalex.org/W2091987058', 'https://openalex.org/W2092787088', 'https://openalex.org/W2092890208', 'https://openalex.org/W2093416195', 'https://openalex.org/W2093721962', 'https://openalex.org/W2094479420', 'https://openalex.org/W2094834583', 'https://openalex.org/W2095083924', 'https://openalex.org/W2095535774', 'https://openalex.org/W2097413546', 'https://openalex.org/W2097606337', 'https://openalex.org/W2099675490', 'https://openalex.org/W2101369849', 'https://openalex.org/W2101939132', 'https://openalex.org/W2103410475', 'https://openalex.org/W2105007068', 'https://openalex.org/W2105929705', 'https://openalex.org/W2107278930', 'https://openalex.org/W2107428059', 'https://openalex.org/W2108886905', 'https://openalex.org/W2108931314', 'https://openalex.org/W2111021707', 'https://openalex.org/W2111055181', 'https://openalex.org/W2111444354', 'https://openalex.org/W2111566256', 'https://openalex.org/W2112041130', 'https://openalex.org/W2112481981', 'https://openalex.org/W2113623006', 'https://openalex.org/W2116695601', 'https://openalex.org/W2117098951', 'https://openalex.org/W2118944608', 'https://openalex.org/W2119704135', 'https://openalex.org/W2123911636', 'https://openalex.org/W2124026319', 'https://openalex.org/W2126189632', 'https://openalex.org/W2126464081', 'https://openalex.org/W2127829230', 'https://openalex.org/W2127901039', 'https://openalex.org/W2127926409', 'https://openalex.org/W2129321368', 'https://openalex.org/W2129476172', 'https://openalex.org/W2129851949', 'https://openalex.org/W2131292600', 'https://openalex.org/W2133155245', 'https://openalex.org/W2135107819', 'https://openalex.org/W2137118785', 'https://openalex.org/W2138403036', 'https://openalex.org/W2138442302', 'https://openalex.org/W2140136203', 'https://openalex.org/W2141210116', 'https://openalex.org/W2141837666', 'https://openalex.org/W2142918729', 'https://openalex.org/W2143729842', 'https://openalex.org/W2147654197', 'https://openalex.org/W2148902400', 'https://openalex.org/W2150922307', 'https://openalex.org/W2151292912', 'https://openalex.org/W2151827426', 'https://openalex.org/W2152204052', 'https://openalex.org/W2152505403', 'https://openalex.org/W2153729880', 'https://openalex.org/W2154461811', 'https://openalex.org/W2154853638', 'https://openalex.org/W2155547021', 'https://openalex.org/W2157924800', 'https://openalex.org/W2158335485', 'https://openalex.org/W2160329764', 'https://openalex.org/W2160587796', 'https://openalex.org/W2160641725', 'https://openalex.org/W2161191369', 'https://openalex.org/W2161718684', 'https://openalex.org/W2161778049', 'https://openalex.org/W2167523976', 'https://openalex.org/W2167732166', 'https://openalex.org/W2167963503', 'https://openalex.org/W2168520668', 'https://openalex.org/W2169584423', 'https://openalex.org/W2170560537', 'https://openalex.org/W2171725368', 'https://openalex.org/W2172294715', 'https://openalex.org/W2176829771', 'https://openalex.org/W2177457327', 'https://openalex.org/W2197012898', 'https://openalex.org/W2233621416', 'https://openalex.org/W2243781553', 'https://openalex.org/W2256785527', 'https://openalex.org/W2262982217', 'https://openalex.org/W2267126247', 'https://openalex.org/W2273971600', 'https://openalex.org/W2285916053', 'https://openalex.org/W2286726801', 'https://openalex.org/W2289043455', 'https://openalex.org/W2290643742', 'https://openalex.org/W2312653119', 'https://openalex.org/W2316253913', 'https://openalex.org/W2318360825', 'https://openalex.org/W2322025889', 'https://openalex.org/W2323132531', 'https://openalex.org/W2329509243', 'https://openalex.org/W2334894007', 'https://openalex.org/W2338577546', 'https://openalex.org/W2345071827', 'https://openalex.org/W2396764557', 'https://openalex.org/W2397353661', 'https://openalex.org/W2398721998', 'https://openalex.org/W2398771789', 'https://openalex.org/W2399105930', 'https://openalex.org/W2404225983', 'https://openalex.org/W2406608326', 'https://openalex.org/W2406800959', 'https://openalex.org/W2409316477', 'https://openalex.org/W2410840537', 'https://openalex.org/W2410884944', 'https://openalex.org/W2411873532', 'https://openalex.org/W2413806342', 'https://openalex.org/W2415850224', 'https://openalex.org/W2416289241', 'https://openalex.org/W2416535366', 'https://openalex.org/W2417522937', 'https://openalex.org/W2418036621', 'https://openalex.org/W2418471265', 'https://openalex.org/W2418956613', 'https://openalex.org/W2419296400', 'https://openalex.org/W2424735538', 'https://openalex.org/W2772971838', 'https://openalex.org/W30942374', 'https://openalex.org/W3151452517', 'https://openalex.org/W349963634', 'https://openalex.org/W4234159707', 'https://openalex.org/W4234658179', 'https://openalex.org/W4249296576', 'https://openalex.org/W4285719527', 'https://openalex.org/W46861897', 'https://openalex.org/W49920453', 'https://openalex.org/W53701705', 'https://openalex.org/W58217582', 'https://openalex.org/W621243529', 'https://openalex.org/W75372324', 'https://openalex.org/W79768257', 'https://openalex.org/W98258303'], 'related_works': ['https://openalex.org/W4212764400', 'https://openalex.org/W3024900260', 'https://openalex.org/W2966233672', 'https://openalex.org/W2383745058', 'https://openalex.org/W2163096595', 'https://openalex.org/W2151894264', 'https://openalex.org/W2071332814', 'https://openalex.org/W2041371840', 'https://openalex.org/W2016149094', 'https://openalex.org/W1968839384'], 'abstract_inverted_index': {'Lentiviral': [0, 21], 'vectors': [1, 22, 49, 70, 73, 82, 121, 130, 149], 'are': [2, 43], 'promising': [3, 26], 'tools': [4, 29], 'for': [5, 30, 48, 168], 'the': [6, 114, 117, 145, 161], 'development': [7], 'of': [8, 92, 116, 126, 147, 163], 'gene': [9, 27, 139, 173], 'therapy': [10, 140, 174], 'since': [11, 34], 'they': [12], 'can': [13, 59, 74, 88, 100, 132, 151], 'transduce': [14, 76], 'both': [15], 'quiescent': [16, 41], 'and': [17, 42, 71, 95, 131, 160], 'dividing': [18, 52], 'target': [19, 36, 46], 'cells.': [20, 80], 'may': [23], 'be': [24, 40, 101, 135], 'particularly': [25], 'delivery': [28], 'hematopoietic': [31, 55, 78], 'stem': [32, 56, 79], 'cells': [33, 37, 47, 57, 105, 167], 'these': [35], 'tend': [38], 'to': [39, 112], 'therefore': [44, 133], 'difficult': [45], 'that': [50, 58, 83, 150], 'require': [51], 'targets.': [53], 'Human': [54], 'repopulate': [60], 'NOD/SCID': [61], 'mice': [62], 'have': [63, 122], 'been': [64], 'efficiently': [65], 'transduced': [66], 'using': [67, 108], 'HIV-1-based': [68], 'lentiviral': [69, 120, 148], 'similar': [72, 124], 'also': [75], 'murine': [77], 'HIV-1': [81], 'contain': [84], 'strong': [85], 'general': [86], 'promoters': [87], 'generate': [89], 'high': [90, 97, 158], 'levels': [91, 99, 159], 'transgene': [93, 156], 'expression': [94, 98, 115], 'very': [96], 'generated': [102], 'in': [103, 106, 137, 171], 'erythroid': [104], 'vivo': [107], 'β-globin': [109], 'regulatory': [110], 'sequences': [111], 'control': [113], 'transgene.': [118], 'Current': [119], 'a': [123], 'level': [125], 'biosafety': [127], 'as': [128], 'oncoretroviral': [129], 'theoretically': [134], 'used': [136], 'clinical': [138, 172], 'protocols.': [141], 'Future': [142], 'challenges': [143], 'include': [144], 'generation': [146, 162], 'express': [152], 'more': [153], 'than': [154], 'one': [155], 'at': [157], 'safe': [164], 'permanent': [165], 'packaging': [166], 'practical': [169], 'use': [170], 'trials.': [175]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1969213969', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-08-31T14:39:26.792575', 'created_date': '2016-06-24'}