Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1969190878', 'doi': 'https://doi.org/10.1124/jpet.102.046847', 'title': 'Contribution of Organic Anion Transporters to the Renal Uptake of Anionic Compounds and Nucleoside Derivatives in Rat', 'display_name': 'Contribution of Organic Anion Transporters to the Renal Uptake of Anionic Compounds and Nucleoside Derivatives in Rat', 'publication_year': 2003, 'publication_date': '2003-03-26', 'ids': {'openalex': 'https://openalex.org/W1969190878', 'doi': 'https://doi.org/10.1124/jpet.102.046847', 'mag': '1969190878', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12660303'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1124/jpet.102.046847', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S102125482', 'display_name': 'Journal of Pharmacology and Experimental Therapeutics', 'issn_l': '0022-3565', 'issn': ['0022-3565', '1521-0103'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316283', 'host_organization_name': 'American Society for Pharmacology and Experimental Therapeutics', 'host_organization_lineage': ['https://openalex.org/P4310316283'], 'host_organization_lineage_names': ['American Society for Pharmacology and Experimental Therapeutics'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5103503773', 'display_name': 'Maki Hasegawa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I74801974', 'display_name': 'The University of Tokyo', 'ror': 'https://ror.org/057zh3y96', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I74801974']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Maki Hasegawa', 'raw_affiliation_strings': ['Graduate School of Pharmaceutical Sciences, University of Tokyo, 7‐3‐1 Hongo, Bunkyo‐ku, Tokyo, 113‐0033, Japan'], 'affiliations': [{'raw_affiliation_string': 'Graduate School of Pharmaceutical Sciences, University of Tokyo, 7‐3‐1 Hongo, Bunkyo‐ku, Tokyo, 113‐0033, Japan', 'institution_ids': ['https://openalex.org/I74801974']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061014418', 'display_name': 'Hiroyuki Kusuhara', 'orcid': 'https://orcid.org/0000-0002-3641-8746'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Hiroyuki Kusuhara', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112719354', 'display_name': 'Hitoshi Endou', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Hitoshi Endou', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5027984186', 'display_name': 'Yuichi Sugiyama', 'orcid': 'https://orcid.org/0000-0002-8452-8835'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yuichi Sugiyama', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 4.899, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 100, 'citation_normalized_percentile': {'value': 0.999911, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '305', 'issue': '3', 'first_page': '1087', 'last_page': '1097'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11027', 'display_name': 'Metabolism and Genetic Disorders', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/1308', 'display_name': 'Clinical Biochemistry'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11465', 'display_name': 'Drug-Induced Hepatotoxicity and Protection', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/estrone-sulfate', 'display_name': 'Estrone sulfate', 'score': 0.80872536}, {'id': 'https://openalex.org/keywords/organic-anion', 'display_name': 'Organic anion', 'score': 0.6556872}, {'id': 'https://openalex.org/keywords/nucleoside-transporter', 'display_name': 'Nucleoside transporter', 'score': 0.43290862}], 'concepts': [{'id': 'https://openalex.org/C2779149875', 'wikidata': 'https://www.wikidata.org/wiki/Q5401864', 'display_name': 'Estrone sulfate', 'level': 4, 'score': 0.80872536}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.7502041}, {'id': 'https://openalex.org/C121421483', 'wikidata': 'https://www.wikidata.org/wiki/Q43457632', 'display_name': 'Organic anion', 'level': 3, 'score': 0.6556872}, {'id': 'https://openalex.org/C2778656385', 'wikidata': 'https://www.wikidata.org/wiki/Q414986', 'display_name': 'Estrone', 'level': 3, 'score': 0.6339889}, {'id': 'https://openalex.org/C123584848', 'wikidata': 'https://www.wikidata.org/wiki/Q18034026', 'display_name': 'Organic anion transporter 1', 'level': 4, 'score': 0.519812}, {'id': 'https://openalex.org/C2780091579', 'wikidata': 'https://www.wikidata.org/wiki/Q9377', 'display_name': 'Kidney', 'level': 2, 'score': 0.48069268}, {'id': 'https://openalex.org/C2776543447', 'wikidata': 'https://www.wikidata.org/wiki/Q28734', 'display_name': 'Nucleoside', 'level': 2, 'score': 0.44564688}, {'id': 'https://openalex.org/C149011108', 'wikidata': 'https://www.wikidata.org/wiki/Q652985', 'display_name': 'Transporter', 'level': 3, 'score': 0.44026667}, {'id': 'https://openalex.org/C2780549722', 'wikidata': 'https://www.wikidata.org/wiki/Q7068260', 'display_name': 'Nucleoside transporter', 'level': 4, 'score': 0.43290862}, {'id': 'https://openalex.org/C189613389', 'wikidata': 'https://www.wikidata.org/wiki/Q70479817', 'display_name': 'Organic cation transport proteins', 'level': 4, 'score': 0.4101572}, {'id': 'https://openalex.org/C71240020', 'wikidata': 'https://www.wikidata.org/wiki/Q186011', 'display_name': 'Stereochemistry', 'level': 1, 'score': 0.39753568}, {'id': 'https://openalex.org/C155647269', 'wikidata': 'https://www.wikidata.org/wiki/Q243455', 'display_name': 'Medicinal chemistry', 'level': 1, 'score': 0.34974265}, {'id': 'https://openalex.org/C145148216', 'wikidata': 'https://www.wikidata.org/wiki/Q36496', 'display_name': 'Ion', 'level': 2, 'score': 0.32886907}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2400783}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.13466975}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.104331315}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000838', 'descriptor_name': 'Anions', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009705', 'descriptor_name': 'Nucleosides', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D027361', 'descriptor_name': 'Organic Anion Transporters', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000838', 'descriptor_name': 'Anions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000838', 'descriptor_name': 'Anions', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D001692', 'descriptor_name': 'Biological Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018076', 'descriptor_name': 'DNA, Complementary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018076', 'descriptor_name': 'DNA, Complementary', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D066298', 'descriptor_name': 'In Vitro Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009705', 'descriptor_name': 'Nucleosides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009705', 'descriptor_name': 'Nucleosides', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D027362', 'descriptor_name': 'Organic Anion Transport Protein 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D027362', 'descriptor_name': 'Organic Anion Transport Protein 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D027361', 'descriptor_name': 'Organic Anion Transporters', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029362', 'descriptor_name': 'Organic Anion Transporters, Sodium-Independent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D029362', 'descriptor_name': 'Organic Anion Transporters, Sodium-Independent', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1124/jpet.102.046847', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S102125482', 'display_name': 'Journal of Pharmacology and Experimental Therapeutics', 'issn_l': '0022-3565', 'issn': ['0022-3565', '1521-0103'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316283', 'host_organization_name': 'American Society for Pharmacology and Experimental Therapeutics', 'host_organization_lineage': ['https://openalex.org/P4310316283'], 'host_organization_lineage_names': ['American Society for Pharmacology and Experimental Therapeutics'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12660303', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.42, 'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 35, 'referenced_works': ['https://openalex.org/W1568250830', 'https://openalex.org/W1893930590', 'https://openalex.org/W1924731409', 'https://openalex.org/W1995297514', 'https://openalex.org/W1996402420', 'https://openalex.org/W2015089407', 'https://openalex.org/W2018424786', 'https://openalex.org/W2033670502', 'https://openalex.org/W2045795758', 'https://openalex.org/W2048541050', 'https://openalex.org/W2048565038', 'https://openalex.org/W2052888437', 'https://openalex.org/W2067650742', 'https://openalex.org/W2071878521', 'https://openalex.org/W2073650307', 'https://openalex.org/W2081750550', 'https://openalex.org/W2082188851', 'https://openalex.org/W2085047894', 'https://openalex.org/W2087526401', 'https://openalex.org/W2088234543', 'https://openalex.org/W2096169020', 'https://openalex.org/W2117979933', 'https://openalex.org/W2127884314', 'https://openalex.org/W2135290874', 'https://openalex.org/W2152702915', 'https://openalex.org/W2160034626', 'https://openalex.org/W2165506335', 'https://openalex.org/W2165860016', 'https://openalex.org/W2169744965', 'https://openalex.org/W2274797767', 'https://openalex.org/W2298286985', 'https://openalex.org/W2318236485', 'https://openalex.org/W2322497786', 'https://openalex.org/W2341436151', 'https://openalex.org/W2463754992'], 'related_works': ['https://openalex.org/W3194807765', 'https://openalex.org/W3165966743', 'https://openalex.org/W2495021492', 'https://openalex.org/W2354121351', 'https://openalex.org/W2152416112', 'https://openalex.org/W2107260421', 'https://openalex.org/W2052888437', 'https://openalex.org/W1997277904', 'https://openalex.org/W1993418630', 'https://openalex.org/W1990524769'], 'abstract_inverted_index': {'Our': [0], 'previous': [1], 'kinetic': [2], 'analyses': [3], 'have': [4], 'shown': [5], 'that': [6, 151, 208], 'rat': [7], 'organic': [8, 38], 'anion': [9], 'transporter': [10], '1': [11], '(rOat1;': [12], '<i>Slc22a6</i>)': [13], 'and': [14, 25, 40, 51, 54, 79, 110, 136, 154, 160, 173, 199, 201, 220, 225, 229, 240], 'rOat3': [15, 196, 202, 230], '(<i>Slc22a8</i>)': [16], 'are': [17], 'responsible': [18], 'for': [19, 195, 217], 'the': [20, 34, 47, 65, 118, 131, 155, 184, 209, 221, 235], 'renal': [21, 35, 210, 236], 'uptake': [22, 36, 48, 66, 90, 144, 169, 211, 222, 237], 'of': [23, 37, 58, 64, 67, 91, 134, 142, 152, 158, 166, 170, 179, 187, 212, 223, 238], '<i>p</i>-aminohippurate': [24], 'pravastatin,': [26], 'respectively.': [27, 204], 'In': [28], 'this': [29], 'study,': [30], 'their': [31, 188], 'contribution': [32], 'to': [33, 164, 193], 'anions': [39], 'nucleoside': [41], 'derivatives': [42], 'was': [43, 148], 'examined': [44], 'by': [45, 49, 145, 175, 218, 227], 'investigating': [46], 'rOat1-': [50], 'rOat3-expressing': [52, 86], 'cells': [53, 87], 'kidney': [55, 124, 146, 176], 'slices.': [56], 'Transfection': [57], 'rOat1': [59, 200, 219], 'resulted': [60], 'in': [61, 123, 126, 234], 'an': [62], 'increase': [63], 'temocaprilat': [68, 92, 239], '(<i>K</i><sub>m</sub>': [69, 93, 99], '=': [70, 76, 83, 94, 100, 107, 114], '0.56': [71], 'μM),': [72, 78, 96, 102, 109], '2,4-dichlorophenoxyacetate': [73], '(2,4-D;': [74], '<i>K</i><sub>m</sub>': [75, 82, 106, 113, 141, 185], '10': [77], '3′-azido-3′-deoxythymidine': [80], '(AZT;': [81], '43': [84], 'μM).': [85, 116], 'showed': [88], 'significant': [89], '1.4': [95], 'estrone': [97, 171, 241], 'sulfate': [98, 104, 172], '5.3': [101], 'dehydroepiandrosterone': [103], '(DHEAS;': [105], '12': [108], 'benzylpenicillin': [111], '(PCG;': [112], '85': [115], 'All': [117], 'test': [119], 'compounds': [120], 'were': [121, 138, 162], 'accumulated': [122], 'slices': [125, 147, 177], 'a': [127], 'carrier-mediated': [128], 'manner,': [129], 'although': [130], 'saturable': [132, 181], 'components': [133, 190], 'AZT': [135], 'acyclovir': [137], 'small.': [139], 'The': [140, 168], '2,4-D': [143, 213], 'comparable': [149], 'with': [150, 183], 'rOat1,': [153], 'corresponding': [156], 'values': [157, 186], 'DHEAS': [159, 226], 'PCG': [161, 224], 'similar': [163, 192], 'those': [165, 194], 'rOat3.': [167], 'temocapilat': [174], 'consisted': [178], 'two': [180], 'components,': [182], 'high-affinity': [189], 'being': [191], '(estrone': [197], 'sulfate),': [198], '(temocaprilat),': [203], 'These': [205], 'results': [206], 'suggest': [207], 'is': [214, 231], 'mainly': [215], 'accounted': [216], 'rOat3,': [228], 'partly': [232], 'involved': [233], 'sulfate.': [242]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1969190878', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 3}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 8}], 'updated_date': '2024-12-08T17:48:55.574636', 'created_date': '2016-06-24'}