Evidence for Androgen‐Dependent Phosphodiesterase Activity in Rat Seminal Vesicle and Epididymis

Name: Work Video:
Duration: 3 min 30 s
Description: This paper deals with findings implying the existence of an androgen-dependent phosphodiesterase (PDE) activity in accessory sexual glands (seminal vesicle and epididymis) of the rat. It is suggested that the PDE activity is not a prerequisite for, but merely a modulator of the overall androgenic response.
O. Djøseland; Jan O. Gordeladze; S. Hôglo; Johan Halse; H. N. Haugen
{'id': 'https://openalex.org/W1969178778', 'doi': 'https://doi.org/10.1111/j.1365-2605.1980.tb00125.x', 'title': 'Evidence for Androgen‐Dependent Phosphodiesterase Activity in Rat Seminal Vesicle and Epididymis', 'display_name': 'Evidence for Androgen‐Dependent Phosphodiesterase Activity in Rat Seminal Vesicle and Epididymis', 'publication_year': 1980, 'publication_date': '1980-12-01', 'ids': {'openalex': 'https://openalex.org/W1969178778', 'doi': 'https://doi.org/10.1111/j.1365-2605.1980.tb00125.x', 'mag': '1969178778', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/6254891'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1365-2605.1980.tb00125.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2605.1980.tb00125.x', 'source': {'id': 'https://openalex.org/S90729755', 'display_name': 'Andrology', 'issn_l': '2047-2919', 'issn': ['2047-2919', '2047-2927'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2605.1980.tb00125.x', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5111600631', 'display_name': 'O. Djøseland', 'orcid': None}, 'institutions': [], 'countries': ['NO'], 'is_corresponding': False, 'raw_author_name': 'O. Djøseland', 'raw_affiliation_strings': ['Laboratory of Endocrinology (Med. Dept. B) and Institute of Pathology, Rikshospitalet, Oslo, Norway.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Endocrinology (Med. Dept. B) and Institute of Pathology, Rikshospitalet, Oslo, Norway.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061480987', 'display_name': 'Jan O. Gordeladze', 'orcid': None}, 'institutions': [], 'countries': ['NO'], 'is_corresponding': False, 'raw_author_name': 'J. O. Gordeladze', 'raw_affiliation_strings': ['Laboratory of Endocrinology (Med. Dept. B) and Institute of Pathology, Rikshospitalet, Oslo, Norway.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Endocrinology (Med. Dept. B) and Institute of Pathology, Rikshospitalet, Oslo, Norway.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053022704', 'display_name': 'S. Hôglo', 'orcid': None}, 'institutions': [], 'countries': ['NO'], 'is_corresponding': False, 'raw_author_name': 'S. Hoglo', 'raw_affiliation_strings': ['Laboratory of Endocrinology (Med. Dept. B) and Institute of Pathology, Rikshospitalet, Oslo, Norway.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Endocrinology (Med. Dept. B) and Institute of Pathology, Rikshospitalet, Oslo, Norway.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020174799', 'display_name': 'Johan Halse', 'orcid': None}, 'institutions': [], 'countries': ['NO'], 'is_corresponding': False, 'raw_author_name': 'J. I. Halse', 'raw_affiliation_strings': ['Laboratory of Endocrinology (Med. Dept. B) and Institute of Pathology, Rikshospitalet, Oslo, Norway.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Endocrinology (Med. Dept. B) and Institute of Pathology, Rikshospitalet, Oslo, Norway.', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5113637070', 'display_name': 'H. N. Haugen', 'orcid': None}, 'institutions': [], 'countries': ['NO'], 'is_corresponding': False, 'raw_author_name': 'H. N. Haugen', 'raw_affiliation_strings': ['Laboratory of Endocrinology (Med. Dept. B) and Institute of Pathology, Rikshospitalet, Oslo, Norway.'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Endocrinology (Med. Dept. B) and Institute of Pathology, Rikshospitalet, Oslo, Norway.', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 11, 'citation_normalized_percentile': {'value': 0.689861, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 82, 'max': 83}, 'biblio': {'volume': '3', 'issue': '1-6', 'first_page': '363', 'last_page': '366'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11146', 'display_name': 'Hormonal and reproductive studies', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11146', 'display_name': 'Hormonal and reproductive studies', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10459', 'display_name': 'Sexual function and dysfunction studies', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/2738', 'display_name': 'Psychiatry and Mental health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10279', 'display_name': 'Urinary Bladder and Prostate Research', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/2748', 'display_name': 'Urology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2781254305', 'wikidata': 'https://www.wikidata.org/wiki/Q1973610', 'display_name': 'Epididymis', 'level': 3, 'score': 0.92473865}, {'id': 'https://openalex.org/C2781171107', 'wikidata': 'https://www.wikidata.org/wiki/Q217259', 'display_name': 'Seminal vesicle', 'level': 4, 'score': 0.8261356}, {'id': 'https://openalex.org/C62826618', 'wikidata': 'https://www.wikidata.org/wiki/Q424304', 'display_name': 'Phosphodiesterase', 'level': 3, 'score': 0.7385225}, {'id': 'https://openalex.org/C2777911890', 'wikidata': 'https://www.wikidata.org/wiki/Q62614', 'display_name': 'Androgen', 'level': 3, 'score': 0.6534542}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.6018781}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5788588}, {'id': 'https://openalex.org/C130316041', 'wikidata': 'https://www.wikidata.org/wiki/Q189206', 'display_name': 'Vesicle', 'level': 3, 'score': 0.51476526}, {'id': 'https://openalex.org/C74534348', 'wikidata': 'https://www.wikidata.org/wiki/Q410798', 'display_name': 'cGMP-specific phosphodiesterase type 5', 'level': 3, 'score': 0.506441}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.42041904}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3968237}, {'id': 'https://openalex.org/C2781087480', 'wikidata': 'https://www.wikidata.org/wiki/Q17145', 'display_name': 'Sperm', 'level': 2, 'score': 0.35297614}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.34913868}, {'id': 'https://openalex.org/C16685009', 'wikidata': 'https://www.wikidata.org/wiki/Q335057', 'display_name': 'Andrology', 'level': 1, 'score': 0.29315683}, {'id': 'https://openalex.org/C2776235491', 'wikidata': 'https://www.wikidata.org/wiki/Q9625', 'display_name': 'Prostate', 'level': 3, 'score': 0.20882249}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.15651941}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.13202736}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.09519449}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0903137}, {'id': 'https://openalex.org/C2779929075', 'wikidata': 'https://www.wikidata.org/wiki/Q184674', 'display_name': 'Erectile dysfunction', 'level': 2, 'score': 0.078167975}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D015105', 'descriptor_name': "3',5'-Cyclic-AMP Phosphodiesterases", 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000242', 'descriptor_name': 'Cyclic AMP', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D004822', 'descriptor_name': 'Epididymis', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D012669', 'descriptor_name': 'Seminal Vesicles', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D015105', 'descriptor_name': "3',5'-Cyclic-AMP Phosphodiesterases", 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002369', 'descriptor_name': 'Castration', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000242', 'descriptor_name': 'Cyclic AMP', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004822', 'descriptor_name': 'Epididymis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009929', 'descriptor_name': 'Organ Size', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011494', 'descriptor_name': 'Protein Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011494', 'descriptor_name': 'Protein Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012669', 'descriptor_name': 'Seminal Vesicles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013739', 'descriptor_name': 'Testosterone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013739', 'descriptor_name': 'Testosterone', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1365-2605.1980.tb00125.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2605.1980.tb00125.x', 'source': {'id': 'https://openalex.org/S90729755', 'display_name': 'Andrology', 'issn_l': '2047-2919', 'issn': ['2047-2919', '2047-2927'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/6254891', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1111/j.1365-2605.1980.tb00125.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2605.1980.tb00125.x', 'source': {'id': 'https://openalex.org/S90729755', 'display_name': 'Andrology', 'issn_l': '2047-2919', 'issn': ['2047-2919', '2047-2927'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 2, 'referenced_works': ['https://openalex.org/W2027047679', 'https://openalex.org/W326742038'], 'related_works': ['https://openalex.org/W30600230', 'https://openalex.org/W2356054385', 'https://openalex.org/W2162729369', 'https://openalex.org/W2099917543', 'https://openalex.org/W2083241041', 'https://openalex.org/W2062107025', 'https://openalex.org/W2059414198', 'https://openalex.org/W1969178778', 'https://openalex.org/W1499923287', 'https://openalex.org/W1418556627'], 'abstract_inverted_index': {'This': [0], 'paper': [1], 'deals': [2], 'with': [3], 'findings': [4], 'implying': [5], 'the': [6, 23, 29, 42], 'existence': [7], 'of': [8, 22, 41], 'an': [9], 'androgen-dependent': [10], 'phosphodiesterase': [11], '(PDE)': [12], 'activity': [13, 31], 'in': [14], 'accessory': [15], 'sexual': [16], 'glands': [17], '(seminal': [18], 'vesicle': [19], 'and': [20], 'epididymis)': [21], 'rat.': [24], 'It': [25], 'is': [26, 32], 'suggested': [27], 'that': [28], 'PDE': [30], 'not': [33], 'a': [34, 39], 'prerequisite': [35], 'for,': [36], 'but': [37], 'merely': [38], 'modulator': [40], 'overall': [43], 'androgenic': [44], 'response.': [45]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1969178778', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-09T08:32:05.070592', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
