Molecular Mechanisms of Bitter and Sweet Taste Transduction

Name: Work Video:
Duration: 3 min 30 s
Robert F. Margolskee
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[200], 'including': [201, 3514], 'depolarize': [205], 'form': [207, 1401, 3240, 3252], 'synapses.': [208], 'typically': [211], 'clustered': [212], 'groups': [214], '∼100': [216], 'within': [217, 434, 2239, 2486, 2792], 'buds.': [219], 'surface': [222], 'TRCs,': [224], 'which': [225, 1489, 3655, 4023], 'makes': [226], 'contact': [227], 'oral': [230], 'cavity,': [231], 'rich': [233], 'convoluted': [235], 'microvilli': [236], 'containing': [237, 1889], 'GPCRs,': [238, 282], 'ion': [239, 251, 1495, 1551], 'channels,': [240], 'elements.': [244], 'basolateral': [246, 4026], 'aspect': [247], 'contains': [250], 'channels': [252, 1552, 4014], 'synapses': [254], 'afferent': [256], 'nerves.': [258], '"Data': [259], 'mining"': [260], 'National': [263], 'Center': [264], 'Biotechnology': [266], 'Information': [267], 'DNA': [268, 1773, 2268], 'sequence': [269, 1774, 2644], 'data': [270, 1767, 1775], 'bases': [271, 1776], 'was': [272, 541, 695, 741, 2324, 2374, 2584, 3007, 3022, 3062], 'used': [273], 'an': [276, 768, 1049, 1222, 2438, 2865, 3731, 4126], '∼25-member': [277], 'multigene': [278], 'family': [279, 291, 2306], 'TRC-expressed': [281, 1424, 2382], 'named': [283], 'T2Rs': [284], 'TRBs': [286], '(so-called': [287], 'second': [290, 3790, 4046], 'identified)': [295], '(1Adler': [296, 504, 553, 615], 'E.': [297, 357, 505, 554, 616, 671, 1095, 1155, 1330, 1846, 2350, 2417, 2561, 2745, 2990], 'Hoon': [298, 506, 555, 617, 668, 2617, 2764, 3137, 3199, 3273], 'M.A.': [299, 507, 556, 618, 669, 1254, 1600, 2348, 2618, 2765, 3138, 3200, 3274], 'Mueller': [300, 508, 557, 619, 666], 'K.L.': [301, 509, 558, 620, 667], 'Chandrashekar': [302, 510, 559, 621, 2619, 2766, 3139, 3201, 3275], 'J.': [303, 366, 511, 560, 622, 665, 805, 967, 975, 1026, 1067, 1101, 1127, 1161, 1175, 1177, 1181, 1471, 1520, 1632, 1853, 1980, 2019, 2352, 2424, 2568, 2620, 2752, 2767, 2997, 3140, 3202, 3276, 3326, 3422, 3425, 3441, 3469, 3818, 3839, 3935, 3938, 3954, 4156, 4183], 'Ryba': [304, 512, 561, 623, 678, 2355, 2623, 2770, 3143, 3205, 3279], 'N.J.P.': [305, 513, 562, 624, 679, 2356, 2624, 2771, 3144, 3206, 3280], 'Zuker': [306, 514, 563, 625, 676, 2357, 2625, 2772, 3145, 3207, 3281], 'C.S.': [307, 515, 564, 626, 677, 2358, 2626, 2773, 3146, 3208, 3282], 'Cell.': [308, 516, 565, 627, 680, 2359, 2627, 2774, 3147, 3209, 3283], '2000;': [309, 327, 517, 566, 585, 628, 681, 1104, 1164, 2842], '10:': [310, 518, 567, 629, 1914], '693-702Abstract': [311, 519, 568, 630], 'Full': [312, 314, 372, 374, 520, 522, 569, 571, 631, 633, 684, 686, 1526, 1528, 2363, 2365, 2631, 2633, 2778, 2780, 3151, 3153, 3213, 3215, 3287, 3289], 'Text': [313, 315, 373, 375, 521, 523, 570, 572, 632, 634, 685, 687, 1527, 1529, 2364, 2366, 2632, 2634, 2779, 2781, 3152, 3154, 3214, 3216, 3288, 3290], 'PDF': [316, 376, 524, 573, 635, 688, 1530, 2367, 2635, 2782, 3155, 3217, 3291], 'Scopus': [317, 331, 377, 393, 411, 525, 574, 589, 636, 690, 790, 851, 866, 902, 956, 1086, 1146, 1188, 1300, 1323, 1350, 1391, 1478, 1532, 1547, 1638, 1717, 1733, 1761, 1801, 1819, 1841, 1859, 1901, 1917, 1974, 1986, 1998, 2012, 2025, 2092, 2180, 2196, 2224, 2295, 2369, 2412, 2430, 2463, 2516, 2534, 2556, 2574, 2611, 2637, 2700, 2718, 2740, 2758, 2784, 2846, 2911, 2945, 2963, 2985, 3003, 3056, 3105, 3157, 3219, 3293, 3331, 3347, 3369, 3382, 3397, 3415, 3431, 3447, 3475, 3538, 3582, 3605, 3645, 3718, 3767, 3824, 3844, 3860, 3882, 3895, 3910, 3928, 3944, 3960, 4162, 4189], '(1059)': [318, 526, 575, 637], 'Google': [319, 333, 379, 395, 413, 527, 576, 591, 638, 692, 792, 811, 853, 868, 904, 958, 1032, 1088, 1108, 1148, 1168, 1190, 1265, 1302, 1325, 1352, 1393, 1480, 1534, 1549, 1611, 1640, 1719, 1735, 1763, 1803, 1821, 1843, 1861, 1903, 1919, 1976, 1988, 2000, 2014, 2027, 2094, 2182, 2198, 2226, 2297, 2371, 2414, 2432, 2465, 2518, 2536, 2558, 2576, 2613, 2639, 2702, 2720, 2742, 2760, 2786, 2848, 2913, 2947, 2965, 2987, 3005, 3058, 3107, 3159, 3221, 3295, 3333, 3349, 3371, 3384, 3399, 3417, 3433, 3449, 3477, 3540, 3584, 3607, 3647, 3720, 3769, 3826, 3846, 3862, 3884, 3897, 3912, 3930, 3946, 3962, 4164, 4191], 'Scholar,2Matsunami': [320], 'H.': [321, 579, 1099, 1159, 1179, 1675, 1790, 1810, 1828, 2138, 2284, 2403, 2450, 2505, 2525, 2543, 2602, 2689, 2709, 2727, 2900, 2934, 2954, 2972, 3045, 3094, 3709, 3756], 'Montmayeur': [322, 580], 'J-P.': [323, 581], 'Buck': [324, 582, 1811, 2404, 2526, 2603, 2710, 2955, 3710], 'L.B.': [325, 583, 1812, 2405, 2527, 2604, 2711, 2956, 3711], 'Nature.': [326, 584, 785, 861, 897, 951, 1295, 1318, 1386, 1542, 2841, 3377, 3392, 3533, 3600, 3890, 3905], '404:': [328, 586], '601-604Crossref': [329, 587], 'PubMed': [330, 392, 410, 588, 689, 789, 810, 850, 865, 901, 955, 1031, 1085, 1107, 1145, 1167, 1187, 1264, 1299, 1322, 1349, 1390, 1477, 1531, 1546, 1610, 1716, 1732, 1760, 1800, 1818, 1840, 1858, 1916, 1973, 1985, 1997, 2011, 2024, 2091, 2179, 2195, 2223, 2294, 2368, 2411, 2429, 2462, 2515, 2533, 2555, 2573, 2610, 2636, 2699, 2717, 2739, 2757, 2783, 2845, 2910, 2944, 2962, 2984, 3002, 3055, 3104, 3156, 3218, 3292, 3330, 3368, 3381, 3396, 3414, 3430, 3446, 3537, 3581, 3604, 3644, 3717, 3766, 3843, 3881, 3894, 3909, 3927, 3943, 3959], '(588)': [332, 590], 'Scholar).': [334, 414, 528, 592, 639, 693, 812, 869, 905, 1033, 1109, 1266, 1394, 1641, 1862, 1920, 2015, 2227, 2298, 2372, 2466, 2577, 2640, 2787, 2914, 3059, 3108, 3160, 3222, 3296, 3608, 3648, 3770, 4165, 4192], 'T2R/TRB': [336, 415, 476, 538, 545, 593, 642, 1420, 1436], 'GPCRs': [337, 423, 2342, 2383, 3992, 4061], 'map': [338], 'regions': [340, 466, 468], 'human': [342, 751, 1770, 2250, 2391], 'mouse': [344, 475, 1772, 2122, 2258], 'chromosomes': [345], 'implicated': [346, 608, 3303, 3454], 'genetically': [347], 'various': [351, 4212], 'compounds': [353, 883, 1000, 1379, 3513], '(3Reed': [354], 'D.R.': [355, 1700, 1742, 2075, 2163, 2205], 'Nanthakumar': [356], 'North': [358], 'M.': [359, 965, 973, 1020, 1077, 1137, 1627, 1677, 1704, 1740, 1778, 1784, 1824, 2079, 2140, 2167, 2203, 2272, 2278, 2446, 2493, 2499, 2539, 2677, 2683, 2723, 2832, 2888, 2894, 2922, 2928, 2968, 3033, 3039, 3082, 3088, 3322, 3338, 3352, 3358, 3376, 3464, 3744, 3750, 3813, 3835, 3851, 3865, 3871, 3889, 4151, 4178], 'Bell': [360], 'C.': [361, 800, 1173, 3438, 3951], 'Bartoshuk': [362], 'L.M.': [363, 1242, 1588], 'Price': [364, 1707, 2082, 2170], 'R.A.': [365, 1708, 2083, 2171], 'Hum.': [367], 'Genet.': [368, 388, 405, 1796, 1968, 1992, 2290, 2511, 2695, 2906, 2940, 3051, 3100, 3762], '1999;': [369, 1082, 1142, 1729, 2192, 2360, 3641], '64:': [370], '1478-1480Abstract': [371], '(112)': [378], 'Scholar,': [380, 396, 577, 793, 854, 1089, 1149, 1169, 1252, 1303, 1326, 1598, 1696, 1720, 1736, 1804, 1822, 1844, 1904, 1977, 1989, 2001, 2159, 2183, 2199, 2415, 2519, 2537, 2559, 2614, 2703, 2721, 2743, 2761, 2948, 2966, 2988, 3334, 3350, 3372, 3385, 3400, 3418, 3434, 3585, 3827, 3847, 3863, 3885, 3898, 3913, 3931, 3947], '4Capeless': [381], 'C.G.': [382, 2003], 'Whitney': [383, 1907, 2004], 'G.': [384, 916, 1016, 1908, 2005, 2616, 2763, 3136, 3198, 3272], 'Azen': [385], 'E.A.': [386], 'Behav.': [387, 1912], '1992;': [389, 786, 1296], '22:': [390], '655-663Crossref': [391], '(55)': [394], '5Lush': [397], 'I.E.': [398, 1961, 1991], 'Hornigold': [399, 1962], 'N.': [400, 948, 1315, 1336, 1673, 1963, 2136, 2824, 3597], 'King': [401, 1964], 'P.': [402, 1091, 1151, 1171, 1965, 3387, 3402, 3900, 3915], 'Stoye': [403, 1966], 'J.P.': [404, 1806, 1967, 2399, 2521, 2598, 2705, 2950, 3705], 'Res.': [406, 1473, 1835, 1969, 1993, 2457, 2550, 2734, 2979], '1995;': [407, 952, 1319, 1543, 1970, 2008, 3601], '66:': [408, 1971], '167-174Crossref': [409, 1972], '(93)': [412, 1975], 'only': [418, 596, 712, 1655, 2316, 2661, 3694], 'distantly': [419], 'related': [420, 2335, 3066], 'such': [424, 1876], 'V1R': [427], 'vomeronasal': [428], 'display': [431], '30–70%': [432], 'identity': [433], 'gene': [436], 'family.': [437], 'These': [438, 1642, 2788, 4107, 4166], 'have': [440, 824, 995, 1275, 1431, 1572, 1654, 3302, 3969, 4199], 'greatest': [442, 461], 'conservation': [443], 'their': [445, 449, 464, 1219, 1884], 'cytoplasmic': [446], 'loops': [447], 'adjacent': [450], 'transmembrane': [451], 'segments': [452], '(predicted': [453], 'sites': [454], 'protein': [457, 607, 705, 771, 1273, 1360, 1426, 1487, 3657, 3668, 4020], 'interaction)': [458], 'divergence': [462], 'extracellular': [465, 2799], '(potential': [467], 'ligand': [470], 'binding).': [471], 'In': [472, 813, 1034, 1267, 2228], 'rat': [473, 4122], 'expressed': [479, 548, 646, 774, 1553, 2344, 2482, 4203], '∼15–20%': [481], 'buds': [486], 'circumvallate': [489, 2490, 4123], 'foliate': [491], 'papillae': [492, 503, 2491, 4124], 'palate': [495], 'but': [496], 'very': [498], 'few': [499], 'fungiform': [502], 'Based': [529, 3801], 'situ': [532, 2579, 3690], 'hybridization': [533, 2580, 3691], 'mixed': [535], 'versus': [536, 702], 'individual': [537], 'probes': [539, 3727], 'concluded': [542], 'that': [543, 756, 826, 925, 997, 1430, 1871, 1950, 2097, 2384, 2582, 2803, 2870, 3008, 3064, 3110, 3182, 3236, 3670, 3693, 3735, 4194], 'most': [544, 2328], 'same': [551, 4117], '2Matsunami': [578], 'found': [597, 696], 'positive': [600, 3701], 'expression': [602, 1397, 3128, 3174, 3224, 3260], 'gustducin': [604, 1042, 1406, 3542, 3558, 3619], '(a': [605, 2269], 'taste)': [611], 'Fig.': [613, 1647, 3483, 4112], '2)': [614], 'One': [640, 1354], 'murine': [641, 660, 1922, 2475], '(mT2R5),': [644], 'when': [645], 'heterologous': [648, 3259], 'cells,': [649, 3234], 'responded': [650], 'cycloheximide': [653], 'at': [654, 3799], 'concentration': [656, 733, 2057], 'comparable': [657], 'threshold': [661, 752], 'aversion': [663], '(6Chandrashekar': [664], 'Adler': [670, 2349], 'Feng': [672], 'L.': [673, 837, 938, 968, 1063, 1123, 1305, 1782, 2276, 2497, 2681, 2892, 2926, 3037, 3086, 3568, 3587, 3748], 'Guo': [674], 'W.': [675, 1014, 1071, 1131, 1906, 3163], '100:': [682, 3366, 3879], '703-711Abstract': [683], '(1104)': [691], 'mT2R5': [694], 'couple': [698, 3661], 'selectively': [699, 773, 2343, 2483, 3672, 4225], 'α-gustducin': [701, 821, 827, 994, 1208, 1270, 1371, 1403, 1414, 1448, 3501, 3703], 'α-subunits.': [706, 1427], 'Taste': [707], 'responses': [708, 879, 1412, 1440, 1886, 2069, 3311, 3509, 4228], 'were': [709, 1942, 2063, 2259, 2478, 2658], 'obtained': [710, 3774], 'from': [711, 923, 1404, 1617, 2647, 2672, 2859, 2917, 3117, 3131, 4095, 4121, 4145], 'one': [713, 2229, 3451, 3988, 4058], 'T2R/TRB-transfected': [715], 'cell;': [716], 'human/mouse': [718], 'orthologous': [719], 'pair,': [720], 'hT2R4/mT2R8,': [721], 'apparently': [722, 1417, 1564], 'encodes': [723], 'responsive': [726, 3190], 'denatonium': [728, 735, 884], '6-n-propyl-2-thiouracil.': [730], 'However,': [731], 'required': [736, 3242], 'stimulate': [738], 'than': [743, 749], '3': [744, 1570], 'orders': [745], 'magnitude': [747], 'higher': [748], 'detection,': [754], 'suggesting': [755, 2096, 3235, 3620], 'another': [757], 'GPCR': [758, 2313, 2317, 2856], 'likely': [760, 2329], '"denatonium"': [764], 'receptor.': [765, 3248], 'α-Gustducin': [766, 870], 'α-transducin-like': [769], 'α-subunit': [772], '∼25–30%': [776], '(7McLaughlin': [779, 1289], 'S.K.': [780, 940, 1290, 1307, 3589], 'McKinnon': [781, 943, 1291, 1310, 3592], 'P.J.': [782, 944, 1292, 1311, 1895, 3593], 'Margolskee': [783, 838, 859, 895, 949, 1078, 1138, 1243, 1293, 1316, 1384, 1540, 1589, 1793, 2287, 2508, 2692, 2903, 2937, 3048, 3097, 3531, 3569, 3598, 3632, 3759], 'R.F.': [784, 839, 860, 896, 950, 1079, 1139, 1244, 1294, 1317, 1385, 1541, 1590, 1794, 2288, 2509, 2693, 2904, 2938, 3049, 3098, 3532, 3570, 3599, 3633, 3760], '357:': [787, 1297], '563-569Crossref': [788, 1298], '(559)': [791, 1301], '8Boughter': [794], 'Jr.,': [795], 'J.D.': [796], 'Pumplin': [797], 'D.W.': [798], 'Yu': [799], 'Christy': [801], 'R.C.': [802], 'Smith': [803, 1909], 'D.V.': [804], 'Neurosci.': [806, 1081, 1141, 1814, 2407, 2529, 2606, 2713, 2958, 3713], '1997;': [807, 1523, 1713, 2088, 2176], '17:': [808], '2852-2858Crossref': [809], 'vitro': [814], 'biochemical': [815, 3298, 3803], 'assays': [816], 'andin': [817], 'vivo': [818], 'analysis': [819], 'knockout': [822, 871, 1372, 1415, 3502], 'mice': [823, 872, 1373, 1875, 1959, 2671, 3122, 3503], 'shown': [825, 996, 1575, 2064, 2479], 'involved': [829, 2854, 3074, 3492], '(9Ming': [834, 3565], 'D.': [835, 942, 971, 1309, 3324, 3566, 3591, 3629, 3837], 'Ruiz-Avila': [836, 3567], 'Proc.': [840, 3571, 3634], 'Natl.': [841, 3572, 3635], 'Acad.': [842, 3573, 3636], 'Sci.': [843, 3574, 3637], 'U.': [844, 1629, 3318, 3320, 3360, 3466, 3575, 3638, 3815, 3831, 3833, 3873, 4153, 4180], 'S.': [845, 910, 970, 1018, 1073, 1097, 1133, 1157, 1338, 1517, 1792, 2286, 2507, 2691, 2836, 2838, 2902, 2936, 3047, 3096, 3165, 3576, 3639, 3758], 'A.': [846, 946, 976, 1313, 1832, 2454, 2547, 2731, 2976, 3410, 3577, 3595, 3640, 3923], '1998;': [847, 1184, 1346, 1474, 3578], '95:': [848, 3579], '8933-8938Crossref': [849, 3580], '(84)': [852, 3583], '10Wong': [855], 'G.T.': [856, 892, 1381, 3528], 'Gannon': [857, 893, 1382, 3529], 'K.S.': [858, 894, 1383, 3530], '1996;': [862, 898, 1387, 1635, 3443, 3472, 3534, 3821, 3956, 4159, 4186], '381:': [863, 899, 1388, 3535], '796-800Crossref': [864, 900, 1389, 3536], '(568)': [867, 903, 1392, 3539], 'show': [873, 3504], 'markedly': [874, 1882], 'reduced': [875], 'behavioral': [876, 3506], 'and/or': [877, 2473, 3507], 'nerve': [878, 2068], 'benzoate,': [885], 'quinine': [886], 'sulfate,': [887], 'cycloheximide,': [888], 'tetraethylammonium': [890], '(10Wong': [891, 1380, 3527], '2V.': [906], 'Danilova,': [907], 'Y.': [908, 1258, 1328, 1340, 1511, 1513, 1604, 1671, 1702, 1750, 1826, 1830, 2077, 2134, 2165, 2213, 2448, 2452, 2541, 2545, 2622, 2725, 2729, 2769, 2826, 2828, 2970, 2974, 3142, 3204, 3278, 3631], 'Danilov,': [909], 'Damak,': [911, 3166], 'R.': [912, 979, 3168], 'F.': [913, 980, 1788, 2282, 2503, 2687, 2898, 2932, 3043, 3092, 3169, 3389, 3404, 3754, 3902, 3917], 'Margolskee,': [914, 981, 3170], 'Hellekant,': [917], 'unpublished': [918, 982, 3171], 'results.': [919, 983, 3172], 'Effector-interacting': [920], 'peptides': [921], 'derived': [922, 2650], 'α-transducin': [924, 1288], 'mimic': [926], 'action': [928], 'activated': [930, 1433, 3545, 3557, 4078], 'transducin/gustducin': [931], 'activate': [932, 4019, 4057], '(PDE)': [936], '(11Ruiz-Avila': [937], 'McLaughlin': [939, 1306, 3588], 'Wildman': [941, 1308, 3590], 'Robichon': [945, 1312, 3594], 'Spickofsky': [947, 1314, 3596], '376:': [953, 1320, 1544, 3602], '80-85Crossref': [954, 1321, 3603], '(177)': [957, 1324, 3606], 'Scholar),': [959, 1191, 2095, 2433], 'recently': [960, 1573, 3116], 'identified': [961, 1277, 1659, 2260, 2325, 2376], 'PDE1A.': [963], '3M.': [964], 'Bakre,': [966], 'Glick,': [969], 'Rybalkin,': [972], 'Max,': [974], 'Beavo,': [977], 'Rapid': [984], 'quench': [985], 'flow': [986], 'studies': [987, 2920, 3301, 3806], 'plus': [988, 3550], 'minus': [990], 'antibodies': [991, 1115, 1203, 1205], 'directed': [992, 1116, 1206], 'against': [993, 1117, 1207], 'lead': [1001, 3982], 'gustducin-mediated': [1004], 'decrease': [1005, 1444], 'tissue': [1008, 1053], '(cNMP)': [1011], 'levels': [1012, 1054, 1500], '(12Yan': [1013], 'Sunavala': [1015], 'Rosenzweig': [1017, 1072, 1132], 'Dasso': [1019], 'Brand': [1021], 'J.G.': [1022], 'Spielman': [1023, 1074, 1134], 'A.I.': [1024, 1075, 1135, 1470], 'Am.': [1025], 'Physiol.': [1027, 1633, 1911, 3342, 3363, 3409, 3470, 3819, 3855, 3876, 3922, 4157, 4184], '2001;': [1028, 1249, 1261, 1595, 1607, 1757, 1797, 1815, 1837, 1855, 2220, 2291, 2408, 2426, 2459, 2512, 2530, 2552, 2570, 2607, 2628, 2696, 2714, 2736, 2754, 2775, 2907, 2941, 2959, 2981, 2999, 3052, 3101, 3148, 3210, 3284, 3714, 3763], '280:': [1029], 'C742-C751Crossref': [1030], 'response': [1035, 1111, 1668, 4131], 'compounds,': [1038], 'βγ-subunits': [1040, 3660], '(identified': [1043], 'Gβ3': [1045], 'Gγ13)': [1047], 'mediate': [1048, 1438, 4226], 'increase': [1050], '(IP3)': [1058], '(DAG)': [1061], '(13Huang': [1062, 1122], 'Shanker': [1064, 1124, 1779, 2273, 2494, 2678, 2889, 2923, 3034, 3083, 3745], 'Y.G.': [1065, 1125, 1780, 2274, 2495, 2679, 2890, 2924, 3035, 3084, 3746], 'Dubauskaite': [1066, 1126], 'Zheng': [1068, 1128], 'J.Z.': [1069, 1129], 'Yan': [1070, 1130], 'Max': [1076, 1136], 'Nat.': [1080, 1140, 1795, 1813, 2289, 2406, 2510, 2528, 2605, 2694, 2712, 2905, 2939, 2957, 3050, 3099, 3712, 3761], '2:': [1083, 1143], '1055-1062Crossref': [1084, 1144], '(290)': [1087, 1147], '14Rossler': [1090, 1150], 'Boekhoff': [1092, 1152], 'I.': [1093, 1153], 'Tareilus': [1094, 1154], 'Beck': [1096, 1156], 'Breer': [1098, 1158, 1178], 'Freitag': [1100, 1160, 1174], 'Chem.': [1102, 1162, 1259, 1522, 1605, 1727, 2006, 2190], 'Senses.': [1103, 1163, 1260, 1606, 1728, 2007, 2191], '25:': [1105, 1165], '413-421Crossref': [1106, 1166], 'This': [1110], 'blocked': [1113], 'Gβ3,': [1118, 1228], 'Gγ13,': [1119, 1229], 'PLCβ2': [1121, 1231, 1584, 3455, 4066, 4083], '15Rossler': [1170], 'Kroner': [1172], 'Noe': [1176], 'Eur.': [1180], 'Cell': [1182, 3341, 3854], 'Biol.': [1183, 1521], '77:': [1185, 1475, 1856, 2427, 2571, 2755, 3000], '253-261Crossref': [1186], '(184)': [1189], 'implicating': [1192], 'all': [1193, 2236, 2667, 2673], 'three': [1194, 1869], 'these': [1196, 1358, 2664, 3563, 3776, 4211, 4222], 'proteins': [1197], 'response;': [1201], 'control': [1202], 'had': [1209, 4125], 'no': [1210], 'effect': [1211], 'IP3': [1213, 1567, 4086, 4089], 'DAG': [1215, 4091], 'generation.': [1216], 'Consistent': [1217], 'IP3/DAG': [1223, 1453, 3457], 'pathway': [1226, 1462, 1562], 'α-gustducin,': [1227], 'co-expressed': [1233, 1578, 2585, 3673], 'large': [1235], 'part': [1236], '(16Clapp': [1239, 1585], 'T.R.': [1240, 1586], 'Stone': [1241, 1587], 'Kinnamon': [1245, 1591, 3423, 3439, 3936, 3952], 'S.C.': [1246, 1592, 3424, 3440, 3937, 3953], 'BMC': [1247, 1593], 'Neuroscience.': [1248, 1594], '6:': [1250, 1596], '2-10Google': [1251, 1597], '17Miyoshi': [1253, 1599], 'Abe': [1255, 1341, 1518, 1601], 'K.': [1256, 1332, 1334, 1342, 1519, 1602, 2840, 3374, 3887], 'Emori': [1257, 1339, 1512, 1603], '26:': [1262, 1608], '259-265Crossref': [1263, 1609], 'addition': [1268], 'several': [1271, 2648, 3192, 3610], 'α-subunits': [1274, 1361], 'been': [1276, 1432, 1574, 1658, 1865, 2115, 2128, 3653, 3970, 4200], '(e.g.': [1280], 'Gαi-2,': [1281], 'Gαi-3,': [1282], 'Gα14,': [1283], 'Gα15,': [1284], 'Gαq,': [1285], 'Gαs,': [1286], '11Ruiz-Avila': [1304, 3586], '18Kusakabe': [1327], 'Yamaguchi': [1329], 'Tanemura': [1331], 'Kameyama': [1333], 'Chiba': [1335], 'Arai': [1337, 1516], 'Biochim.': [1343], 'Biophys.': [1344, 1834, 2456, 2549, 2733, 2978], 'Acta.': [1345], '1403:': [1347], '265-272Crossref': [1348], '(45)': [1351], 'Scholar)).': [1353], 'play': [1363], 'because': [1370, 3781], 'retain': [1374], 'residual': [1375, 1411], 'responsiveness': [1376, 1929, 1940], 'Furthermore,': [1395, 3060], 'transgenic': [1396, 3127], 'dominant-negative': [1400], 'promoter': [1407], 'further': [1408, 3480], 'decreased': [1409, 1482], 'mice,': [1416, 2653], 'inhibiting': [1419], 'interactions': [1421], 'Gustducin': [1428, 3489], 'heterotrimers': [1429], 'bitter-stimulated': [1435], 'TRCs:': [1442], 'cNMPs': [1446, 1483], 'via': [1447, 1454, 3987, 4143], 'rise': [1451], 'βγ-gustducin.': [1455], 'subsequent': [1457, 1557], 'steps': [1458, 1558], 'α-gustducin-PDE-cNMP': [1461], 'presently': [1464, 4219], 'uncertain': [1465], '(reviewed': [1466], 'Ref.': [1468], '19Spielman': [1469], 'Dent.': [1472], '539-544Crossref': [1476], '(17)': [1479], 'Scholar);': [1481, 3450, 3721], 'act': [1485, 4006, 4016], 'kinases,': [1488], 'turn': [1491], 'regulate': [1493, 1502], 'TRC': [1494, 3310, 4103], 'channel': [1496], 'activity,': [1497], 'cNMP': [1499], 'directly': [1503, 4007], 'activity': [1505], 'cNMP-gated': [1507, 4013], '(20Misaka': [1508], 'T.': [1509, 1515, 1744, 2207, 2830, 2834, 3354, 3867], 'Kusakabe': [1510, 1825, 2447, 2540, 2724, 2969], 'Gonoi': [1514], '272:': [1524], '22623-22629Abstract': [1525], '(74)': [1533], 'Scholar)': [1535, 1550, 1764, 2028, 3006, 3478, 3963], 'cNMP-inhibited': [1537], '(21Kolesnikov': [1538], 'S.S.': [1539], '85-88Crossref': [1545], '(100)': [1548], 'TRCs.': [1555], 'βγ-gustducin-PLC-IP3/DAG': [1561], 'activation': [1565, 3617, 3984], '(type': [1569], 'IP3receptors': [1571], 'Gγ13': [1582], 'Scholar))': [1612, 2849], 'release': [1614, 1623, 4094, 4144], 'Ca2+': [1616, 4040, 4093, 4129, 4142], 'internal': [1618, 4096, 4146], 'stores': [1619, 4147], 'followed': [1620], 'neurotransmitter': [1622, 4043, 4105], '(22Bernhardt': [1624, 3461, 3810, 4148, 4175], 'S.J.': [1625, 3462, 3811, 4149, 4176], 'Naim': [1626, 3321, 3337, 3463, 3812, 3834, 3850, 4150, 4177], 'Zehavi': [1628, 3319, 3359, 3465, 3814, 3832, 3872, 4152, 4179], 'Lindemann': [1630, 3339, 3390, 3405, 3467, 3816, 3852, 3903, 3918, 4154, 4181], 'B.': [1631, 1724, 2187, 3340, 3364, 3391, 3406, 3468, 3817, 3853, 3877, 3904, 3919, 4155, 4182], '(Lond.).': [1634, 3471, 3820, 4158, 4185], '490:': [1636, 3473, 3822, 4160, 4187], '325-336Crossref': [1637, 3474, 3823, 4161, 4188], '(199)': [1639, 3476, 3825, 4163, 4190], 'pathways': [1643, 3795, 4109], 'diagrammed': [1645], '1.': [1648], 'just': [1656], 'now': [1657], 'based': [1660, 3016], 'earlier': [1662, 2919], 'genetic': [1663, 1948], 'mapping': [1664], 'loci': [1669, 1923], '(23Ninomiya': [1670, 2133], 'Sako': [1672, 2135], 'Katsukawa': [1674, 2137], 'Funakoshi': [1676, 2139, 3375, 3888], 'Wysocki': [1678, 2141], 'C.J.': [1679, 2142], 'Kare': [1680, 2143], 'M.R.': [1681, 2144], 'Chemical': [1682, 2145], 'Senses:': [1683, 2146], 'Genetics': [1684, 2147], 'Perception': [1686, 2149], 'Communication.': [1688, 2151], '3.': [1689, 2152], 'Marcel': [1690, 2153], 'Dekker,': [1691, 2154], 'Inc.,': [1692, 2155], 'New': [1693, 2156], 'York1991:': [1694, 2157], '267-278Google': [1695, 2158], '24Bachmanov': [1697, 2160], 'A.A.': [1698, 1754, 2073, 2161, 2217], 'Reed': [1699, 1741, 2074, 2162, 2204], 'Ninomiya': [1701, 1749, 1829, 2076, 2164, 2212, 2451, 2544, 2728, 2973, 3630], 'Inoue': [1703, 1739, 2078, 2166, 2202], 'Tordoff': [1705, 1747, 2080, 2168, 2210], 'M.G.': [1706, 1748, 2081, 2169, 2211], 'Beauchamp': [1709, 1751, 2084, 2172, 2214], 'G.K.': [1710, 1752, 2085, 2173, 2215], 'Mamm.': [1711, 1755, 2086, 2174, 2218], 'Genome.': [1712, 1756, 2087, 2175, 2219], '8:': [1714, 2089, 2177], '545-548Crossref': [1715, 2090, 2178], '(101)': [1718, 2093, 2181], '25Blizzard': [1721, 2184], 'D.A.': [1722, 2185], 'Kotlus': [1723, 2186], 'Frank': [1725, 2188], 'M.E.': [1726, 2189], '24:': [1730, 2193], '373-385Crossref': [1731, 2194], '(70)': [1734, 2197], '26Li': [1737, 2200], 'X.': [1738, 2201], 'Huque': [1743, 2206], 'Puchalski': [1745, 2208], 'R.B.': [1746, 2209], 'Bachmanov': [1753, 2216], '12:': [1758, 2221], '13-16Crossref': [1759, 2222], '(105)': [1762, 2225], 'mining': [1768], '(27Max': [1777, 2271, 2492, 2676, 2887, 2921, 3032, 3081, 3743], 'Huang': [1781, 2275, 2496, 2680, 2891, 2925, 3036, 3085, 3747], 'Rong': [1783, 2277, 2498, 2682, 2893, 2927, 3038, 3087, 3749], 'Liu': [1785, 2279, 2500, 2684, 2895, 2929, 3040, 3089, 3751], 'Z.': [1786, 2280, 2501, 2685, 2896, 2930, 3041, 3090, 3752], 'Campagne': [1787, 2281, 2502, 2686, 2897, 2931, 3042, 3091, 3753], 'Weinstein': [1789, 2283, 2504, 2688, 2899, 2933, 3044, 3093, 3755], 'Damak': [1791, 2285, 2506, 2690, 2901, 2935, 3046, 3095, 3757], '28:': [1798, 2292, 2513, 2697, 2908, 2942, 3053, 3102, 3764], '58-63Crossref': [1799, 2293, 2514, 2698, 2909, 2943, 3054, 3103, 3765], '(469)': [1802, 2296, 2517, 2701, 2912, 2946, 3057, 3106, 3768], '28Montmayeur': [1805, 2520, 2704, 2949], 'Liberles': [1807, 2400, 2522, 2599, 2706, 2951, 3706], 'S.D.': [1808, 2401, 2523, 2600, 2707, 2952, 3707], 'Matsunami': [1809, 2402, 2524, 2601, 2708, 2953, 3708], '4:': [1816, 2409, 2531, 2608, 2715, 2960, 3715], '492-498Crossref': [1817, 2410, 2532, 2609, 2716, 2961, 3716], '(407)': [1820, 2413, 2535, 2612, 2719, 2964, 3719], '29Kitagawa': [1823, 2538, 2722, 2967], 'Miura': [1827, 2449, 2542, 2726, 2971], 'Hino': [1831, 2453, 2546, 2730, 2975], 'Biochem.': [1833, 2455, 2548, 2732, 2977, 3325, 3343, 3362, 3408, 3838, 3856, 3875, 3921], 'Commun.': [1836, 2458, 2551, 2735, 2980], '283:': [1838, 2460, 2553, 2737, 2982], '236-242Crossref': [1839, 2461, 2554, 2738, 2983], '(295)': [1842, 2464, 2557, 2741, 2986], '30Sainz': [1845, 2416, 2560, 2744, 2989], 'Korley': [1847, 2418, 2562, 2746, 2991], 'J.N.': [1848, 2419, 2563, 2747, 2992], 'Battey': [1849, 2353, 2420, 2564, 2748, 2993], 'J.F.': [1850, 2354, 2421, 2565, 2749, 2994], 'Sullivan': [1851, 2422, 2566, 2750, 2995], 'S.L.': [1852, 2423, 2567, 2751, 2996], 'Neurochem.': [1854, 2425, 2569, 2753, 2998], '896-903Crossref': [1857, 2428, 2572, 2756, 3001], '(284)': [1860, 2431, 2575, 2759, 3004], 'It': [1863, 3649, 4217], 'has': [1864, 2114, 2127, 3114, 3267, 3453, 3650], 'some': [1868, 2108], 'decades': [1870], 'inbred': [1872], 'strains': [1873, 1957, 2651, 2669, 2675], 'C57BL/6': [1878, 2045], 'DBA/2': [1880, 2047], 'differ': [1881], 'ingestive': [1885], 'solutions': [1888, 2051], 'artificial': [1891, 3195, 3520, 3555, 3611, 4051, 4136, 4234], 'sweetener': [1892], '(31Capretta': [1894], 'Psychogenomic': [1896], 'Science.': [1897], '1970;': [1898], '21:': [1899], '133-135Crossref': [1900], '(18)': [1902], '32Pelz': [1905], 'J.C.': [1910], '1973;': [1913], '263-265Crossref': [1915], '(50)': [1918], 'sac(determines': [1925], 'preference': [1926, 1938, 2037], 'electrophysiological': [1928, 3300, 3508, 3805], 'saccharin,': [1931, 3522], 'sucrose,': [1932, 3515, 4133], 'sweeteners)': [1935], 'dpa(determines': [1937], 'tod-phenylalanine)': [1941], 'major': [1947], 'factors': [1949], 'determine': [1951], 'differences': [1952, 2042, 3783], 'between': [1953, 3623], 'sweet-preferring': [1954], 'sweet-indifferent': [1956], '(5Lush': [1960], '33Fuller': [1978], 'J.L.': [1979, 2018], 'Hered.': [1981, 2020], '1974;': [1982, 2021], '65:': [1983, 2022], '33-36Crossref': [1984, 2023], '(144)': [1987, 2026], '34Lush': [1990], '1989;': [1994, 3327, 3840], '53:': [1995], '95-99Crossref': [1996], '(145)': [1999], '35Capeless': [2002], '20:': [2009], '291-298Crossref': [2010], '(71)': [2013, 3448, 3961], 'Fuller': [2016], '(33Fuller': [2017], 'first': [2029, 3973], 'proposed': [2030], 'existence': [2032], 'single': [2035], 'gene,sac,': [2038], 'explain': [2040], 'exhibited': [2043], 'ingestion': [2049], 'covering': [2054], 'wide': [2056], 'range.': [2058], 'Both': [2059], 'dpa': [2060, 2126], 'sac': [2062, 2113, 2255, 3113], 'affect': [2066], 'peripheral': [2067], 'sucrose': [2071, 3553, 3978], '(24Bachmanov': [2072], 'either': [2098, 4068], 'both': [2100], 'genes': [2101, 2237], 'might': [2102], 'encode': [2103], 'element.': [2112], 'mapped': [2116, 2129, 2385], 'distal': [2119], 'end': [2120], 'chromosome': [2123], '4,': [2124], 'proximal': [2131], '4': [2132], 'approach': [2230], 'candidates': [2233, 3679], 'sac,': [2235], 'present': [2238], 'region': [2241, 2256, 2320, 2388, 2397, 2800], '∼1': [2243], 'million': [2244], 'base': [2245], 'pairs': [2246], 'sequenced': [2249], 'genome': [2251, 2392], 'syntenous': [2252, 2393], 'ordered': [2262], 'into': [2263, 3123], 'contiguous': [2265], 'stretch': [2266], '"contig")': [2270], 'From': [2299], 'search': [2301, 2440], 'T1R3': [2302, 2332, 2373, 2472, 3111, 3130], '(human': [2303], '1,': [2307], 'member': [2308], '3),': [2309], 'previously': [2311], 'unknown': [2312], 'genome,': [2323], 'candidate': [2330, 3013], 'forsac.': [2331], '∼30%': [2334], 'T1R1': [2337], 'T1R2,': [2339], '"orphan"': [2341], '(36Hoon': [2347], 'Lindemeier': [2351], '96:': [2361, 3642], '541-551Abstract': [2362], '(575)': [2370], 'also': [2375, 3072, 3700], 'independently': [2377, 2649], 'searches': [2379], 'novel': [2381, 2442], 'murinesac': [2396], '(28Montmayeur': [2398, 2597, 3704], 'RT-PCR': [2439, 3724], '(29Kitagawa': [2445], 'As': [2467], 'befits': [2468], 'receptor,': [2471], 'ortholog': [2476], '(T1r3)': [2477], 'fungiform,': [2487], 'foliate,': [2488], 'Doublein': [2578], 'showed': [2581], 'T1r3': [2583, 2646, 2802, 2858, 2878, 3009, 3176, 3226, 3726], 'T1r1': [2587, 3067, 3262], 'anterior': [2589], 'T1r2': [2593, 3069, 3180, 3228], 'posterior': [2595], '37Nelson': [2615, 2762], 'Zhang': [2621, 2768, 3141, 3203, 3277], '106:': [2629, 2776, 3149, 3211, 3285], '381-390Abstract': [2630, 2777, 3150, 3212, 3286], '(1407)': [2638, 2785, 3158, 3220, 3294], 'By': [2641], 'comparing': [2642], 'eight': [2654], 'polymorphisms': [2657, 2665, 2790], 'identified;': [2659], 'however,': [2660, 3258, 3722], 'differentiated': [2666], 'taster': [2668, 3133], 'non-taster': [2674, 3121], 'occur': [2791], 'specific': [2794], 'portion': [2795], 'N-terminal': [2798, 2819, 2867], '(based': [2804], 'homology': [2806], 'mGluR1': [2808, 2822], '(metabotropic': [2809], 'glutamate': [2810], '1)': [2812, 4113], 'structure': [2816, 2876], 'domain': [2820], '(38Kunishima': [2823], 'Shimada': [2825], 'Tsuji': [2827], 'Sato': [2829], 'Yamamoto': [2831], 'Kumasaka': [2833], 'Nakanishi': [2835], 'Jingami': [2837], 'Morikawa': [2839], '407:': [2843], '971-977Crossref': [2844], '(1118)': [2847], 'predicted': [2851, 2862, 3023, 3063], 'dimerization.': [2857], 'non-tasters': [2860], 'contain': [2864], 'extra': [2866], 'glycosylation': [2868], 'site': [2869], 'models': [2873, 3020, 3965, 4213], 'would': [2879, 3071, 3677], 'preclude': [2880], 'hetero-': [2882], 'homodimerization': [2884], 'Fig.3)': [2886], 'conclusion': [2916], 'strong': [3012], 'forsac,': [3014], 'molecular': [3019], 'sweet-responsive': [3027, 3233, 4119, 4167, 4196], '(i.e.': [3028], 'sweet-liganded)': [3029], 'Confirmation': [3109], 'come': [3115], 'conversion': [3119], 'tasters': [3124], 'strain': [3134], '(37Nelson': [3135, 3197, 3271], '4M.': [3161], 'Rong,': [3162], 'He,': [3164], 'Heterologous': [3173, 3223], 'combination': [3178], 'demonstrated': [3181], 'heterodimer': [3184], 'comprises': [3185], 'functional': [3187, 3246, 3255], 'natural': [3193], 'sweeteners': [3196, 3521, 3556, 3612, 4052, 4137], 'alone': [3229, 3263], 'did': [3230], 'not': [3231, 3651, 3797], 'yield': [3232], 'T1r3/T1r2': [3238], 'heterodimeric': [3239], 'manifest': [3244], 'Presumably,': [3249], 'T1r3/T1r1': [3250], 'heterodimers': [3251, 3266], 'generate': [3254, 4002, 4085], 'receptors;': [3257, 3665], 'T1r1-containing': [3265], 'failed': [3268], 'date': [3270], 'Several': [3297], 'Gs,': [3304], 'adenylyl': [3305, 3999], 'cyclase,': [3306], 'cAMP': [3308, 4004, 4227], 'tastants': [3314], '(39Striem': [3315], 'B.J.': [3316, 3336, 3356, 3829, 3849, 3869], 'Pace': [3317, 3830], 'Lancet': [3323, 3836], '260:': [3328, 3841], '121-126Crossref': [3329, 3842], '(147)': [3332, 3845], '40Striem': [3335, 3848], '1991;': [3344, 3365, 3857, 3878], '1:': [3345, 3858], '46-54Crossref': [3346, 3859], '(81)': [3348, 3861], '41Naim': [3351, 3864], 'Ronen': [3353, 3866], 'Striem': [3355, 3868], 'Levenson': [3357, 3870], 'Comp.': [3361, 3407, 3874, 3920], '455-458Crossref': [3367, 3880], '(19)': [3370, 3883], '42Tonosaki': [3373, 3886], '1988;': [3378, 3393, 3411, 3891, 3906, 3924], '331:': [3379, 3394, 3892, 3907], '354-356Crossref': [3380, 3893], '(128)': [3383, 3896], '43Avenet': [3386, 3899], 'Hofmann': [3388, 3403, 3901, 3916], '351-354Crossref': [3395, 3908], '(158)': [3398, 3911], '44Avenet': [3401, 3914], '90:': [3412, 3925], '681-685Crossref': [3413, 3926], '(7)': [3416, 3929], '45Cummings': [3419, 3932], 'T.A.': [3420, 3436, 3933, 3949], 'Powell': [3421, 3934], 'Neurophysiol.': [3426, 3442, 3939, 3955], '1993;': [3427, 3940], '70:': [3428, 3941], '2326-2336Crossref': [3429, 3942], '(90)': [3432, 3945], '46Cummings': [3435, 3948], 'Daniels': [3437, 3950], '75:': [3444, 3957], '1256-1263Crossref': [3445, 3958], 'study': [3452], '(for': [3479], 'details': [3481], 'see': [3482], '1': [3484], '"Transduction': [3486], 'Pathways"': [3487], 'below).': [3488], 'responses;': [3500], 'diminished': [3505], 'proline,': [3516], 'tryptophan,': [3517], 'acesulfame': [3523], 'K,': [3524], 'SC45647': [3526, 4140], 'Scholar).2Although': [3541], 'could': [3543, 4224], 'receptor-containing': [3548], 'bitters,': [3551], 'neither': [3552], 'nor': [3554], 'presence': [3561], 'Interestingly,': [3609], 'competitively': [3613], 'inhibited': [3614], 'potential': [3621], 'cross-talk': [3622], '(47Ming': [3628], '9903-9908Crossref': [3643], '(75)': [3646], 'yet': [3652], 'determined': [3654], 'α-': [3658], 'T1r': [3664, 3675, 3682, 3994, 4197], 'any': [3666, 4172], 'subunits': [3669], 'coupling': [3681], 'downstream': [3685], 'pathways.': [3687], 'Double': [3688], 'indicates': [3692], '10–20%': [3695], 'T1r3-positive': [3697], 'single-cell': [3723], 'immunohistochemistry': [3729], 'anti-T1R3': [3732], 'antibody': [3733], 'indicated': [3734], 'about': [3736], 'two-thirds': [3737], 'T1r3/T1R3-positive': [3739], 'α-gustducin-positive': [3742], 'discrepant': [3772], 'results': [3773], 'different': [3777], 'techniques': [3778], 'sensitivity.': [3785], 'effector': [3787], 'enzymes': [3788], 'messengers': [3791], 'T1r-mediated': [3793], 'present.': [3800], '39Striem': [3828], 'proposed.': [3971], 'GPCR-Gs-cAMP': [3976], 'pathway;': [3977, 4050], 'sugars': [3981, 4230], 'Gs': [3986], 'coupled': [3991, 4064], '(presumably': [3993], 'heterodimers);': [3995], 'receptor-activated': [3996], 'Gαs': [3997], 'activates': [3998, 4082], 'cyclase': [4000], 'cAMP;': [4003], 'cause': [4009], 'cation': [4010], 'influx': [4011, 4127], 'through': [4012], 'indirectly': [4017], 'kinase': [4021], 'A,': [4022], 'phosphorylates': [4024], 'K+channel,': [4027], 'leading': [4028, 4098], 'closure': [4030], 'channel,': [4033], 'depolarization': [4034, 4100], 'cell,': [4038], 'voltage-dependent': [4039], 'influx,': [4041], 'release.': [4044, 4106], 'GPCR-Gq/Gβγ-IP3': [4049], 'presumably': [4053], 'bind': [4054], '(T1r': [4062], 'heterodimers?)': [4063], 'α': [4070], 'subunit': [4071], 'Gq': [4073], 'Gβγ': [4076, 4081], 'subunits;': [4077], 'Gαqor': [4079], 'released': [4080], 'DAG;': [4088], 'elicit': [4092], 'stores,': [4097], '(diagrammed': [4110], 'coexist': [4114], 'TRCs;': [4118], 'whereas': [4134], 'elevated': [4141], 'didnot': [4169], 'respond': [4170], 'stimuli': [4174], 'Now': [4193], 'cloned': [4201], 'should': [4205], 'possible': [4207], 'definitively': [4209], 'test': [4210], 'transduction.': [4216], 'unclear': [4220], 'how': [4221], 'IP3responses': [4232], 'sweeteners.': [4235]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1969104991', 'counts_by_year': [{'year': 2024, 'cited_by_count': 10}, {'year': 2023, 'cited_by_count': 12}, {'year': 2022, 'cited_by_count': 18}, {'year': 2021, 'cited_by_count': 23}, {'year': 2020, 'cited_by_count': 17}, {'year': 2019, 'cited_by_count': 28}, {'year': 2018, 'cited_by_count': 13}, {'year': 2017, 'cited_by_count': 16}, {'year': 2016, 'cited_by_count': 15}, {'year': 2015, 'cited_by_count': 21}, {'year': 2014, 'cited_by_count': 15}, {'year': 2013, 'cited_by_count': 21}, {'year': 2012, 'cited_by_count': 19}], 'updated_date': '2024-12-26T21:36:59.863640', 'created_date': '2016-06-24'}
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