Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1969094464', 'doi': 'https://doi.org/10.1006/bbrc.2002.6648', 'title': 'Expression Profile Analysis of Colon Cancer Cells in Response to Sulindac or Aspirin', 'display_name': 'Expression Profile Analysis of Colon Cancer Cells in Response to Sulindac or Aspirin', 'publication_year': 2002, 'publication_date': '2002-03-01', 'ids': {'openalex': 'https://openalex.org/W1969094464', 'doi': 'https://doi.org/10.1006/bbrc.2002.6648', 'mag': '1969094464', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11906190'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1006/bbrc.2002.6648', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S151589183', 'display_name': 'Biochemical and Biophysical Research Communications', 'issn_l': '0006-291X', 'issn': ['0006-291X', '1090-2104'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5081907383', 'display_name': 'Masayoshi Iizaka', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I96036126', 'display_name': 'Kumamoto University', 'ror': 'https://ror.org/02cgss904', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I96036126']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masayoshi Iizaka', 'raw_affiliation_strings': ['Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan', 'Second Department of Surgery, School of Medicine, Kumamoto University, Kumamoto, Japan'], 'affiliations': [{'raw_affiliation_string': 'Second Department of Surgery, School of Medicine, Kumamoto University, Kumamoto, Japan', 'institution_ids': ['https://openalex.org/I96036126']}, {'raw_affiliation_string': 'Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018161559', 'display_name': 'Yoichi Furukawa', 'orcid': 'https://orcid.org/0000-0003-0462-8631'}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Yoichi Furukawa', 'raw_affiliation_strings': ['Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049989071', 'display_name': 'Tatsuhiko Tsunoda', 'orcid': 'https://orcid.org/0000-0002-5439-7918'}, 'institutions': [{'id': 'https://openalex.org/I4210110652', 'display_name': 'RIKEN', 'ror': 'https://ror.org/01sjwvz98', 'country_code': 'JP', 'type': 'facility', 'lineage': ['https://openalex.org/I4210110652']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tatsuhiko Tsunoda', 'raw_affiliation_strings': ['Laboratory for Medical Informatics, SNP Research Center, Riken (Institute of Physical and Chemical Research), Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Laboratory for Medical Informatics, SNP Research Center, Riken (Institute of Physical and Chemical Research), Tokyo, Japan', 'institution_ids': ['https://openalex.org/I4210110652']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062012379', 'display_name': 'Hirofumi Akashi', 'orcid': None}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hirofumi Akashi', 'raw_affiliation_strings': ['Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103477245', 'display_name': 'Michio Ogawa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I96036126', 'display_name': 'Kumamoto University', 'ror': 'https://ror.org/02cgss904', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I96036126']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Michio Ogawa', 'raw_affiliation_strings': ['Second Department of Surgery, School of Medicine, Kumamoto University, Kumamoto, Japan'], 'affiliations': [{'raw_affiliation_string': 'Second Department of Surgery, School of Medicine, Kumamoto University, Kumamoto, Japan', 'institution_ids': ['https://openalex.org/I96036126']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5101940699', 'display_name': 'Yusuke Nakamura', 'orcid': 'https://orcid.org/0000-0001-5288-5750'}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Yusuke Nakamura', 'raw_affiliation_strings': ['Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5101940699'], 'corresponding_institution_ids': [], 'apc_list': {'value': 2770, 'currency': 'USD', 'value_usd': 2770, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.967, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 37, 'citation_normalized_percentile': {'value': 0.747882, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 90, 'max': 91}, 'biblio': {'volume': '292', 'issue': '2', 'first_page': '498', 'last_page': '512'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10678', 'display_name': 'Inflammatory mediators and NSAID effects', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10678', 'display_name': 'Inflammatory mediators and NSAID effects', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10756', 'display_name': 'Estrogen and related hormone effects', 'score': 0.9936, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11503', 'display_name': 'Cytokine Signaling Pathways and Interactions', 'score': 0.9919, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/sulindac', 'display_name': 'Sulindac', 'score': 0.98550594}], 'concepts': [{'id': 'https://openalex.org/C2776241388', 'wikidata': 'https://www.wikidata.org/wiki/Q963093', 'display_name': 'Sulindac', 'level': 3, 'score': 0.98550594}, {'id': 'https://openalex.org/C2777628954', 'wikidata': 'https://www.wikidata.org/wiki/Q18216', 'display_name': 'Aspirin', 'level': 2, 'score': 0.85684896}, {'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.7607336}, {'id': 'https://openalex.org/C2779689624', 'wikidata': 'https://www.wikidata.org/wiki/Q410251', 'display_name': 'Cyclooxygenase', 'level': 3, 'score': 0.5921303}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5746969}, {'id': 'https://openalex.org/C186836561', 'wikidata': 'https://www.wikidata.org/wiki/Q1931516', 'display_name': 'Microarray', 'level': 4, 'score': 0.5217075}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.5124886}, {'id': 'https://openalex.org/C8415881', 'wikidata': 'https://www.wikidata.org/wiki/Q6839217', 'display_name': 'Microarray analysis techniques', 'level': 4, 'score': 0.50501114}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.46902385}, {'id': 'https://openalex.org/C111669997', 'wikidata': 'https://www.wikidata.org/wiki/Q17163050', 'display_name': 'Mouse model of colorectal and intestinal cancer', 'level': 4, 'score': 0.4666588}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4380843}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.43426353}, {'id': 'https://openalex.org/C187882448', 'wikidata': 'https://www.wikidata.org/wiki/Q283478', 'display_name': 'Complementary DNA', 'level': 3, 'score': 0.43320155}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.41708228}, {'id': 'https://openalex.org/C2778484676', 'wikidata': 'https://www.wikidata.org/wiki/Q20707196', 'display_name': 'Nonsteroidal', 'level': 2, 'score': 0.3759304}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.36153668}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.25204122}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.17668161}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.13552469}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.081831455}], 'mesh': [{'descriptor_ui': 'D000894', 'descriptor_name': 'Anti-Inflammatory Agents, Non-Steroidal', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D016588', 'descriptor_name': 'Anticarcinogenic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D001241', 'descriptor_name': 'Aspirin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013467', 'descriptor_name': 'Sulindac', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000894', 'descriptor_name': 'Anti-Inflammatory Agents, Non-Steroidal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016588', 'descriptor_name': 'Anticarcinogenic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001241', 'descriptor_name': 'Aspirin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D003110', 'descriptor_name': 'Colonic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020869', 'descriptor_name': 'Gene Expression Profiling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020411', 'descriptor_name': 'Oligonucleotide Array Sequence Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012334', 'descriptor_name': 'RNA, Neoplasm', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D012334', 'descriptor_name': 'RNA, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013467', 'descriptor_name': 'Sulindac', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1006/bbrc.2002.6648', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S151589183', 'display_name': 'Biochemical and Biophysical Research Communications', 'issn_l': '0006-291X', 'issn': ['0006-291X', '1090-2104'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11906190', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.85, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 43, 'referenced_works': ['https://openalex.org/W140965324', 'https://openalex.org/W1539601638', 'https://openalex.org/W1570736525', 'https://openalex.org/W1656544709', 'https://openalex.org/W1781950500', 'https://openalex.org/W1919144095', 'https://openalex.org/W1968262266', 'https://openalex.org/W1972714691', 'https://openalex.org/W1979201752', 'https://openalex.org/W1996115734', 'https://openalex.org/W1996344228', 'https://openalex.org/W1998394615', 'https://openalex.org/W2004722555', 'https://openalex.org/W2015543753', 'https://openalex.org/W2019390040', 'https://openalex.org/W2019897388', 'https://openalex.org/W2034078695', 'https://openalex.org/W2035523654', 'https://openalex.org/W2038197749', 'https://openalex.org/W2038212272', 'https://openalex.org/W2038554369', 'https://openalex.org/W2051686420', 'https://openalex.org/W2068994065', 'https://openalex.org/W2070970078', 'https://openalex.org/W2073148985', 'https://openalex.org/W2077478539', 'https://openalex.org/W2109560931', 'https://openalex.org/W2109970232', 'https://openalex.org/W2120574072', 'https://openalex.org/W2122953993', 'https://openalex.org/W2130421382', 'https://openalex.org/W2138973456', 'https://openalex.org/W2154672659', 'https://openalex.org/W2161765887', 'https://openalex.org/W2164786703', 'https://openalex.org/W2167629420', 'https://openalex.org/W2170604759', 'https://openalex.org/W2200616997', 'https://openalex.org/W2263192284', 'https://openalex.org/W2318479442', 'https://openalex.org/W2338655541', 'https://openalex.org/W2402670656', 'https://openalex.org/W2417895837'], 'related_works': ['https://openalex.org/W4298274096', 'https://openalex.org/W4239989086', 'https://openalex.org/W2904189335', 'https://openalex.org/W2486004046', 'https://openalex.org/W2399236170', 'https://openalex.org/W2130770049', 'https://openalex.org/W2074426684', 'https://openalex.org/W1965103142', 'https://openalex.org/W1963529117', 'https://openalex.org/W1568687113'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1969094464', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2025-01-22T20:06:56.209512', 'created_date': '2016-06-24'}