Publication Information

{'id': 'https://openalex.org/W1968811274', 'doi': 'https://doi.org/10.1371/journal.pone.0074650', 'title': 'Inorganic Polyphosphate Suppresses Lipopolysaccharide-Induced Inducible Nitric Oxide Synthase (iNOS) Expression in Macrophages', 'display_name': 'Inorganic Polyphosphate Suppresses Lipopolysaccharide-Induced Inducible Nitric Oxide Synthase (iNOS) Expression in Macrophages', 'publication_year': 2013, 'publication_date': '2013-09-09', 'ids': {'openalex': 'https://openalex.org/W1968811274', 'doi': 'https://doi.org/10.1371/journal.pone.0074650', 'mag': '1968811274', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24040305', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3767636'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0074650', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0074650&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0074650&type=printable', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5009240299', 'display_name': 'Kana Harada', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I113306721', 'display_name': 'Hiroshima University', 'ror': 'https://ror.org/03t78wx29', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I113306721']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Kana Harada', 'raw_affiliation_strings': ['Department of Advanced Prosthodontics, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Advanced Prosthodontics, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan', 'institution_ids': ['https://openalex.org/I113306721']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019528844', 'display_name': 'Toshikazu Shiba', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210154200', 'display_name': 'Kitasato Institute Hospital', 'ror': 'https://ror.org/05js82y61', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210154200']}, {'id': 'https://openalex.org/I64189623', 'display_name': 'Kitasato University', 'ror': 'https://ror.org/00f2txz25', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I64189623']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Toshikazu Shiba', 'raw_affiliation_strings': ['Laboratory for Polyphosphate Research, The Kitasato Institute, Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan', 'Regenetiss Inc., Koganei, Japan'], 'affiliations': [{'raw_affiliation_string': 'Laboratory for Polyphosphate Research, The Kitasato Institute, Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan', 'institution_ids': ['https://openalex.org/I4210154200', 'https://openalex.org/I64189623']}, {'raw_affiliation_string': 'Regenetiss Inc., Koganei, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050981130', 'display_name': 'Kazuya Doi', 'orcid': 'https://orcid.org/0000-0001-9452-4750'}, 'institutions': [{'id': 'https://openalex.org/I113306721', 'display_name': 'Hiroshima University', 'ror': 'https://ror.org/03t78wx29', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I113306721']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Kazuya Doi', 'raw_affiliation_strings': ['Department of Advanced Prosthodontics, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Advanced Prosthodontics, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan', 'institution_ids': ['https://openalex.org/I113306721']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073046727', 'display_name': 'Koji Morita', 'orcid': 'https://orcid.org/0000-0002-5724-5573'}, 'institutions': [{'id': 'https://openalex.org/I113306721', 'display_name': 'Hiroshima University', 'ror': 'https://ror.org/03t78wx29', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I113306721']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Koji Morita', 'raw_affiliation_strings': ['Department of Advanced Prosthodontics, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Advanced Prosthodontics, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan', 'institution_ids': ['https://openalex.org/I113306721']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109377251', 'display_name': 'Takayasu Kubo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I113306721', 'display_name': 'Hiroshima University', 'ror': 'https://ror.org/03t78wx29', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I113306721']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Takayasu Kubo', 'raw_affiliation_strings': ['Department of Advanced Prosthodontics, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Advanced Prosthodontics, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan', 'institution_ids': ['https://openalex.org/I113306721']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017584545', 'display_name': 'Yusuke Makihara', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I113306721', 'display_name': 'Hiroshima University', 'ror': 'https://ror.org/03t78wx29', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I113306721']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Yusuke Makihara', 'raw_affiliation_strings': ['Department of Advanced Prosthodontics, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Advanced Prosthodontics, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan', 'institution_ids': ['https://openalex.org/I113306721']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006986981', 'display_name': 'Adriano Piattelli', 'orcid': 'https://orcid.org/0000-0002-6246-8130'}, 'institutions': [{'id': 'https://openalex.org/I39387349', 'display_name': 'University of Chieti-Pescara', 'ror': 'https://ror.org/00qjgza05', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I39387349']}], 'countries': ['IT'], 'is_corresponding': True, 'raw_author_name': 'Adriano Piattelli', 'raw_affiliation_strings': ['Department of Medical, Oral and Biotechnological Sciences, Chieti-Pescara University, Chieti, Italy'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical, Oral and Biotechnological Sciences, Chieti-Pescara University, Chieti, Italy', 'institution_ids': ['https://openalex.org/I39387349']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5034990453', 'display_name': 'Yasumasa Akagawa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I113306721', 'display_name': 'Hiroshima University', 'ror': 'https://ror.org/03t78wx29', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I113306721']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Yasumasa Akagawa', 'raw_affiliation_strings': ['Department of Advanced Prosthodontics, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Advanced Prosthodontics, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan', 'institution_ids': ['https://openalex.org/I113306721']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5009240299', 'https://openalex.org/A5019528844', 'https://openalex.org/A5050981130', 'https://openalex.org/A5073046727', 'https://openalex.org/A5109377251', 'https://openalex.org/A5017584545', 'https://openalex.org/A5006986981', 'https://openalex.org/A5034990453'], 'corresponding_institution_ids': ['https://openalex.org/I113306721', 'https://openalex.org/I4210154200', 'https://openalex.org/I64189623', 'https://openalex.org/I113306721', 'https://openalex.org/I113306721', 'https://openalex.org/I113306721', 'https://openalex.org/I113306721', 'https://openalex.org/I39387349', 'https://openalex.org/I113306721'], 'apc_list': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'apc_paid': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'fwci': 1.141, 'has_fulltext': False, 'cited_by_count': 17, 'citation_normalized_percentile': {'value': 0.859587, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 89, 'max': 90}, 'biblio': {'volume': '8', 'issue': '9', 'first_page': 'e74650', 'last_page': 'e74650'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11917', 'display_name': 'Coagulation, Bradykinin, Polyphosphates, and Angioedema', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11917', 'display_name': 'Coagulation, Bradykinin, Polyphosphates, and Angioedema', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T13004', 'display_name': 'Vitamin K Research Studies', 'score': 0.9597, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11730', 'display_name': 'Autoimmune Bullous Skin Diseases', 'score': 0.935, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/polyphosphate', 'display_name': 'Polyphosphate', 'score': 0.652779}], 'concepts': [{'id': 'https://openalex.org/C2778754761', 'wikidata': 'https://www.wikidata.org/wiki/Q421804', 'display_name': 'Lipopolysaccharide', 'level': 2, 'score': 0.89012945}, {'id': 'https://openalex.org/C2777622882', 'wikidata': 'https://www.wikidata.org/wiki/Q417619', 'display_name': 'Nitric oxide synthase', 'level': 3, 'score': 0.8612564}, {'id': 'https://openalex.org/C519581460', 'wikidata': 'https://www.wikidata.org/wiki/Q207843', 'display_name': 'Nitric oxide', 'level': 2, 'score': 0.8138136}, {'id': 'https://openalex.org/C2778038992', 'wikidata': 'https://www.wikidata.org/wiki/Q420783', 'display_name': 'Polyphosphate', 'level': 3, 'score': 0.652779}, {'id': 'https://openalex.org/C136449434', 'wikidata': 'https://www.wikidata.org/wiki/Q428253', 'display_name': 'Innate immune system', 'level': 3, 'score': 0.5756844}, {'id': 'https://openalex.org/C2779244956', 'wikidata': 'https://www.wikidata.org/wiki/Q184204', 'display_name': 'Macrophage', 'level': 3, 'score': 0.5037846}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.49073994}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4877325}, {'id': 'https://openalex.org/C17991360', 'wikidata': 'https://www.wikidata.org/wiki/Q21173843', 'display_name': 'Tumor necrosis factor alpha', 'level': 2, 'score': 0.47564077}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.42098778}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.40154755}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.39610216}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.3800518}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.33194023}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.21440166}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.2026476}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.13883549}, {'id': 'https://openalex.org/C2777132085', 'wikidata': 'https://www.wikidata.org/wiki/Q46220103', 'display_name': 'Phosphate', 'level': 2, 'score': 0.06889516}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D052247', 'descriptor_name': 'Nitric Oxide Synthase Type II', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010710', 'descriptor_name': 'Phosphates', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002473', 'descriptor_name': 'Cell Wall', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002473', 'descriptor_name': 'Cell Wall', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007113', 'descriptor_name': 'Immunity, Innate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007249', 'descriptor_name': 'Inflammation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008070', 'descriptor_name': 'Lipopolysaccharides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008264', 'descriptor_name': 'Macrophages', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017737', 'descriptor_name': 'Macrophages, Peritoneal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017737', 'descriptor_name': 'Macrophages, Peritoneal', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D009569', 'descriptor_name': 'Nitric Oxide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052247', 'descriptor_name': 'Nitric Oxide Synthase Type II', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009573', 'descriptor_name': 'Nitrites', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D009573', 'descriptor_name': 'Nitrites', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010710', 'descriptor_name': 'Phosphates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011122', 'descriptor_name': 'Polyphosphates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011122', 'descriptor_name': 'Polyphosphates', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014409', 'descriptor_name': 'Tumor Necrosis Factor-alpha', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0074650', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0074650&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3767636', 'pdf_url': 'https://europepmc.org/articles/pmc3767636?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767636', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24040305', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0074650', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0074650&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 31, 'referenced_works': ['https://openalex.org/W1968721371', 'https://openalex.org/W1972003023', 'https://openalex.org/W1985342306', 'https://openalex.org/W1986541440', 'https://openalex.org/W1991600999', 'https://openalex.org/W1994942139', 'https://openalex.org/W2012154760', 'https://openalex.org/W2013511860', 'https://openalex.org/W2046971159', 'https://openalex.org/W2047818159', 'https://openalex.org/W2062266980', 'https://openalex.org/W2064232485', 'https://openalex.org/W2065524859', 'https://openalex.org/W2065880897', 'https://openalex.org/W2073707438', 'https://openalex.org/W2079553299', 'https://openalex.org/W2083884362', 'https://openalex.org/W2095294463', 'https://openalex.org/W2098478717', 'https://openalex.org/W2098852054', 'https://openalex.org/W2109491705', 'https://openalex.org/W2113351822', 'https://openalex.org/W2139347632', 'https://openalex.org/W2142997199', 'https://openalex.org/W2143516276', 'https://openalex.org/W2155443888', 'https://openalex.org/W2160427162', 'https://openalex.org/W2162897717', 'https://openalex.org/W2171480404', 'https://openalex.org/W226215395', 'https://openalex.org/W4233576685'], 'related_works': ['https://openalex.org/W3036630261', 'https://openalex.org/W2811214525', 'https://openalex.org/W2520592962', 'https://openalex.org/W2355383679', 'https://openalex.org/W2118461223', 'https://openalex.org/W208559191', 'https://openalex.org/W1984505360', 'https://openalex.org/W1981432316', 'https://openalex.org/W1968811274', 'https://openalex.org/W1547547003'], 'abstract_inverted_index': {'In': [0, 94, 125], 'response': [1], 'to': [2, 15, 35], 'infection,': [3], 'macrophages': [4], 'produce': [5], 'a': [6, 45, 66, 143], 'series': [7], 'of': [8, 20, 48, 70, 134, 146], 'inflammatory': [9, 137], 'mediators,': [10], 'including': [11], 'nitric': [12, 57], 'oxide': [13, 58], '(NO),': [14], 'eliminate': [16], 'pathogens.': [17], 'The': [18], 'production': [19], 'these': [21], 'molecules': [22], 'is': [23, 81], 'tightly': [24], 'regulated': [25], 'via': [26], 'various': [27], 'mechanisms,': [28], 'as': [29, 142], 'excessive': [30], 'responses': [31], 'are': [32], 'often': [33], 'detrimental': [34], 'host': [36], 'tissues.': [37], 'Here,': [38], 'we': [39], 'report': [40], 'that': [41, 113], 'inorganic': [42], 'polyphosphate': [43], '[poly(P)],': [44], 'linear': [46], 'polymer': [47], 'orthophosphate': [49], 'ubiquitously': [50], 'found': [51], 'in': [52, 73, 89, 153], 'mammalian': [53], 'cells,': [54], 'suppresses': [55], 'inducible': [56], 'synthase': [59], '(iNOS)': [60], 'expression': [61, 106, 118, 152], 'induced': [62, 107], 'by': [63, 108, 119, 149], 'lipopolysaccharide': [64], '(LPS),': [65], 'cell': [67], 'wall': [68], 'component': [69], 'Gram-negative': [71], 'bacteria,': [72], 'mouse': [74], 'peritoneal': [75], 'macrophages.': [76, 154], 'Poly(P)': [77, 139], 'with': [78, 86], 'longer': [79], 'chains': [80, 88], 'more': [82], 'potent': [83], 'than': [84], 'those': [85], 'shorter': [87], 'suppressing': [90], 'LPS-induced': [91, 98, 116, 132], 'iNOS': [92, 104, 117, 151], 'expression.': [93], 'addition,': [95], 'poly(P)': [96, 102, 114, 127], 'decreased': [97], 'NO': [99], 'release.': [100], 'Moreover,': [101], 'suppressed': [103], 'mRNA': [105, 123], 'LPS': [109], 'stimulation,': [110], 'thereby': [111], 'indicating': [112], 'reduces': [115], 'down-regulation': [120], 'at': [121], 'the': [122, 131], 'level.': [124], 'contrast,': [126], 'did': [128], 'not': [129], 'affect': [130], 'release': [133], 'TNF,': [135], 'another': [136], 'mediator.': [138], 'may': [140], 'serve': [141], 'regulatory': [144], 'factor': [145], 'innate': [147], 'immunity': [148], 'modulating': [150]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1968811274', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 3}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 2}], 'updated_date': '2024-12-07T18:29:39.053591', 'created_date': '2016-06-24'}