Phosphorylation of Histones by Tissue Transglutaminase

Name: Work Video:
Duration: 3 min 30 s
Suresh Mishra; Ali Saleh; Paula S. Espino; James Davie; Liam J. Murphy
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2782, 4065], 'to': [8, 18, 37, 133, 179, 189, 208, 304, 523, 586, 691, 731, 768, 770, 776, 782, 807, 811, 952, 955, 996, 1167, 1292, 1491, 1539, 1566, 1658, 1702, 1760, 1974, 2158, 2400, 2499, 2536, 2714, 2860, 2865, 2976, 3012, 3254, 3270, 3403, 3468, 3475, 3581, 3622, 3627, 3655, 3745, 3831, 4105, 4130, 4194], 'have': [9, 127, 180, 298, 864, 945, 1052, 4063], 'intrinsic': [10, 181, 960, 3973], 'serine/threonine': [11, 182, 498], 'kinase': [12, 32, 183, 203, 499, 961, 1340, 1426, 2235, 2725, 3370, 3478, 3541, 3974, 4060, 4074, 4125, 4160, 4173, 4182], 'activity.': [13, 33, 184, 204, 3542, 4061], 'Since': [14, 185, 889], 'histones': [15, 26, 45, 186, 197, 216, 641, 795, 883, 900, 1335, 1610, 2228, 2554, 2881, 3502], 'are': [16, 27, 187, 198, 774, 805, 994, 1164, 1274, 1336, 2223, 4055, 4076, 4103], 'known': [17, 188, 995, 4000], 'be': [19, 190, 732, 783, 797, 824, 997, 1290, 2861, 3013, 4135], 'cross-linked': [20, 191, 2535], 'by': [21, 68, 74, 192, 239, 245, 589, 688, 821, 893, 1012, 1099, 1509, 1544, 1674, 1690, 1707, 2023, 2026, 2249, 2293, 2366, 2415, 2559, 2576, 2669, 2943, 3020, 3064, 3076, 3085, 3195, 3386, 3408, 3636, 3771, 3867, 3874, 3942, 3955, 4137], 'TG2,': [22, 193, 350, 374, 949, 1296, 1368, 2670], 'we': [23, 54, 79, 126, 194, 225, 250, 297, 1332, 2997, 3570, 3965], 'investigated': [24, 195, 1333], 'whether': [25, 196, 1334], 'also': [28, 199, 728, 958, 1053, 1193, 2781, 3441, 4056, 4163], 'substrates': [29, 50, 200, 221, 1337, 4001, 4057], 'for': [30, 161, 201, 332, 578, 735, 826, 1009, 1338, 1443, 1497, 1518, 1531, 1632, 1664, 1685, 1698, 1777, 1834, 1860, 1922, 1979, 1993, 2012, 2076, 2179, 2187, 2350, 2379, 2406, 2432, 2543, 2857, 3539, 3814, 4002, 4058, 4071], 'TG2': [31, 34, 57, 75, 83, 96, 111, 130, 162, 202, 205, 228, 246, 254, 267, 282, 301, 333, 558, 689, 736, 822, 879, 894, 940, 1096, 1161, 1191, 1264, 1288, 1339, 1424, 1643, 2080, 2294, 2560, 2577, 2696, 2715, 2742, 2829, 2937, 3021, 3065, 3115, 3124, 3246, 3304, 3354, 3368, 3452, 3471, 3498, 3535, 3630, 3660, 3671, 3790, 3818, 3893, 3910, 3937, 3971, 4007, 4059, 4073, 4112, 4170, 4177, 4191], 'was': [35, 66, 113, 206, 237, 284, 1373, 1460, 1507, 1583, 1672, 1743, 2046, 2128, 2199, 2308, 2364, 2370, 2496, 2509, 2516, 2572, 2603, 2637, 2657, 2667, 2675, 2712, 2736, 2739, 2789, 2823, 2839, 2952, 2965, 2972, 3017, 3027, 3035, 3117, 3179, 3231, 3432, 3440, 3456, 3466, 3687, 3697, 3704, 3710, 3737, 3757, 3782, 3829, 3895, 4192], 'able': [36, 132, 207, 303, 4193], 'phosphorylate': [38, 134, 209, 305, 4195], 'H1,': [39, 210, 726], 'H2A,': [40, 211, 986, 3420, 3675], 'H2B,': [41, 212, 687, 987, 3421, 3676], 'H3,': [42, 213, 988, 2996, 3677], 'and': [43, 51, 62, 86, 108, 119, 138, 140, 145, 169, 214, 222, 233, 257, 279, 290, 309, 311, 316, 340, 495, 535, 686, 694, 800, 802, 817, 835, 868, 989, 991, 999, 1017, 1160, 1344, 1439, 1462, 1479, 1494, 1521, 1529, 1542, 1551, 1557, 1569, 1573, 1644, 1661, 1680, 1688, 1696, 1705, 1736, 1740, 1758, 1769, 1826, 1977, 1999, 2021, 2034, 2071, 2085, 2112, 2133, 2154, 2191, 2229, 2323, 2376, 2389, 2404, 2472, 2487, 2502, 2505, 2548, 2555, 2568, 2582, 2592, 2629, 2716, 2729, 2777, 2813, 2830, 2882, 2931, 2938, 2940, 2945, 3048, 3059, 3073, 3078, 3089, 3129, 3142, 3165, 3216, 3225, 3228, 3258, 3282, 3311, 3384, 3396, 3406, 3410, 3422, 3464, 3472, 3488, 3499, 3511, 3589, 3602, 3616, 3631, 3638, 3678, 3718, 3730, 3773, 3834, 3836, 3859, 3861, 3872, 3876, 3901, 3938, 3996, 4069, 4101, 4118, 4171, 4199], 'H4': [44, 215, 2684, 3423, 3679, 3695, 3731], 'in': [46, 60, 88, 97, 116, 121, 142, 151, 163, 217, 231, 259, 268, 287, 292, 313, 322, 334, 405, 526, 561, 764, 785, 829, 903, 950, 1048, 1270, 1370, 1425, 1500, 1577, 1620, 1745, 1766, 1813, 1849, 1882, 1905, 1939, 1951, 2006, 2015, 2096, 2116, 2135, 2166, 2225, 2233, 2295, 2298, 2312, 2326, 2382, 2464, 2474, 2562, 2606, 2660, 2686, 2747, 2763, 2783, 2900, 2902, 2905, 2908, 2910, 2915, 2995, 3066, 3247, 3278, 3286, 3350, 3358, 3369, 3479, 3490, 3529, 3562, 3566, 3605, 3607, 3723, 3805, 3852, 3885, 3898, 3903, 3911, 4108, 4115, 4178, 4180, 4188], 'vitro.': [47, 218], 'Using': [48, 219], 'peptide': [49, 220, 2613, 2674, 2788, 2799, 2812, 2838, 2964, 3184, 3194, 3686, 3696], 'phosphospecific': [52, 223, 1796, 3038, 3594], 'antibodies': [53, 224, 1776, 1798, 1833, 3595], 'demonstrated': [55, 80, 128, 226, 251, 299, 947], 'that': [56, 63, 81, 129, 227, 234, 252, 300, 401, 592, 780, 878, 948, 1004, 1104, 1260, 1267, 1278, 2615, 2648, 2705, 2741, 3003, 3459, 3666, 3715, 3970, 3998, 4066], 'phosphorylated': [58, 84, 229, 255, 799, 1549, 1567, 2558, 2575, 2668, 2737, 2743, 3019, 3063, 3426, 3565], 'Ser10': [59, 73, 230, 244, 3046, 3588, 3600], 'H3': [61, 87, 139, 232, 258, 310, 1011, 2296, 2749, 2761, 2922, 3000, 3026, 3044, 3055, 3229, 3357, 3431, 3463, 3489, 3563, 3606, 3685, 3729, 3939], 'this': [64, 235, 936, 1281, 1330, 3683, 4200], 'phosphorylation': [65, 71, 236, 242, 1005, 1050, 1454, 1468, 1786, 2288, 2381, 2682, 2994, 3009, 3032, 3116, 3125, 3152, 3188, 3222, 3306, 3332, 3455, 3461, 3625, 4201], 'reduced': [67, 115, 238, 286, 3133, 3897], 'acetylation,': [69, 240], 'whereas': [70, 241, 2671, 2796], 'of': [72, 95, 166, 243, 266, 337, 564, 567, 581, 680, 794, 891, 939, 1006, 1058, 1102, 1287, 1295, 1421, 1453, 1466, 1482, 1511, 1587, 1596, 1602, 1608, 1638, 1642, 1676, 1712, 1731, 1785, 1787, 1842, 1902, 1908, 1931, 1947, 2018, 2079, 2162, 2289, 2303, 2329, 2335, 2347, 2358, 2385, 2412, 2460, 2524, 2589, 2600, 2618, 2651, 2654, 2679, 2683, 2695, 2698, 2708, 2720, 2755, 2771, 2804, 2810, 2835, 2845, 2853, 2877, 2887, 2929, 2950, 2955, 2959, 2992, 3033, 3053, 3069, 3100, 3106, 3110, 3126, 3150, 3156, 3177, 3191, 3208, 3214, 3223, 3237, 3250, 3299, 3307, 3314, 3319, 3331, 3336, 3438, 3451, 3462, 3515, 3534, 3659, 3670, 3817, 3909, 3936, 4006], 'enhanced': [76, 120, 247, 291, 3189, 3902], 'acetylation.': [77, 248], 'Furthermore': [78, 249], 'exogenous': [82, 253], 'H1': [85, 141, 256, 312, 993, 2556, 3445, 3465, 3487], 'nucleosome': [89, 260, 904, 3481, 3568, 3574], 'preparations.': [90, 261], 'We': [91, 262, 3145, 4062], 'examined': [92, 263, 3147], 'the': [93, 164, 264, 335, 527, 530, 533, 536, 569, 579, 587, 681, 791, 827, 859, 887, 899, 1061, 1263, 1303, 1350, 1451, 1464, 1467, 1492, 1574, 1594, 1636, 1659, 1681, 1713, 1726, 1741, 1773, 1843, 1929, 2000, 2160, 2163, 2234, 2287, 2299, 2330, 2348, 2356, 2359, 2361, 2383, 2401, 2458, 2506, 2533, 2593, 2598, 2607, 2611, 2619, 2624, 2634, 2643, 2649, 2652, 2661, 2672, 2680, 2687, 2693, 2699, 2706, 2709, 2732, 2748, 2756, 2764, 2772, 2797, 2801, 2814, 2818, 2836, 2846, 2850, 2858, 2870, 2962, 2969, 3067, 3111, 3127, 3138, 3148, 3157, 3166, 3182, 3192, 3206, 3209, 3238, 3248, 3263, 3449, 3460, 3469, 3480, 3516, 3530, 3567, 3573, 3657, 3688, 3698, 3708, 3724, 3760, 3767, 3795, 3868, 3930, 3945, 4003, 4067, 4072, 4172], 'abundance': [94, 112, 265, 283, 3884, 3894], 'DNA-associated': [98, 269, 2413, 3912, 3917], 'proteins': [99, 270, 403, 1407, 1536, 1550, 1568, 1735, 1752, 2394, 2534, 3856, 3913, 3918], 'from': [100, 271, 886, 1349, 1361, 1375, 1387, 1398, 1412, 1874, 2245, 2338, 3362, 3612, 3754, 3857, 3914, 3921, 3949], 'MCF-7': [101, 272, 2089, 2246, 2340, 2425, 3613, 3853, 3863, 3915, 3922], 'cells': [102, 118, 273, 289, 1163, 1346, 1879, 2093, 2130, 2341, 2424, 2426, 2469, 3756, 3833, 3864, 3900, 3905, 3923, 4117], 'treated': [103, 274, 1718, 2174, 3617, 3924], 'with': [104, 149, 275, 320, 1418, 1561, 1613, 1649, 1719, 1772, 1795, 1828, 1855, 1871, 1884, 1899, 1985, 2081, 2104, 2122, 2175, 2183, 2344, 2429, 2457, 2519, 2529, 2610, 2642, 2828, 2863, 2936, 2974, 3037, 3181, 3243, 3256, 3268, 3367, 3497, 3527, 3583, 3618, 3629, 3649, 3661, 3674, 3712, 3728, 3739, 3759, 3775, 3785, 3819, 3850, 3879, 3925, 4078, 4165, 4176], 'phorbol': [105, 276, 355, 379], 'ester': [106, 277], '(TPA)': [107, 278], '17β-estradiol': [109, 280], '(E2).': [110, 281], 'significantly': [114, 285, 3896], 'E2-treated': [117, 288, 3899], 'TPA-treated': [122, 293, 3862, 3904], 'cells.': [123, 154, 294, 325, 3916], 'In': [124, 295, 427, 1329, 1533, 2632, 2692, 2925, 2967, 3173, 3219, 3233, 3260, 3448, 3492, 3522, 3682, 3749, 3809, 3944], 'summary': [125, 296], 'is': [131, 147, 302, 318, 394, 521, 559, 572, 576, 584, 931, 1097, 1262, 1268, 2780, 3010, 3520, 3792, 4113, 4119, 4127, 4162], 'purified': [135, 306], 'histone': [136, 307, 360, 384, 683, 892, 992, 1049, 1406, 1471, 1845, 1891, 2644, 2655, 2664, 2700, 2733, 2773, 2883, 3112, 3158, 3308, 3376, 3392, 3419, 3430, 3444, 3454, 3651, 3747], 'proteins,': [137, 308, 957, 1715, 2504, 3821], 'chromatin': [143, 150, 167, 314, 321, 338, 787, 809, 2197, 2221, 2501, 3360], 'preparations,': [144, 315], 'it': [146, 317, 429, 575, 638, 876, 930, 1000, 1261, 4133], 'associated': [148, 319, 2503, 3855], 'breast': [152, 323, 2091], 'cancer': [153, 324], 'These': [155, 326, 3543], 'studies': [156, 327], 'suggest': [157, 328], 'a': [158, 329, 395, 437, 465, 497, 562, 590, 733, 765, 1100, 1501, 1578, 1746, 1788, 2074, 2117, 2718, 2723, 2916, 3030, 3279, 3351, 3381, 3399, 3476, 3506, 3537, 3548, 3764, 3798, 3806, 3812], 'novel': [159, 330], 'role': [160, 331], 'regulation': [165, 336], 'structure': [168, 339, 810], 'function.': [170, 341, 788], '4The': [346, 370, 3212], 'abbreviations': [347, 371], 'used': [348, 372, 3028, 3654], 'are:': [349, 373], 'tissue': [351, 375], '2;': [353, 377], 'TPA,': [354, 378], 'ester;': [356, 380], 'E2,': [357, 381], '17β-estradiol;': [358, 382], 'HAT,': [359, 383], 'acetyltransferase;': [361, 385], 'HRP,': [362, 386], 'horseradish': [363, 387, 1829], 'peroxidase;': [364, 388], 'DMEM,': [365, 389], "Dulbecco's": [366, 390], 'modified': [367, 391], "Eagle's": [368, 392], 'medium.': [369, 393], 'ubiquitously': [396], 'expressed,': [397], 'calcium-dependent': [398], 'trans-amidating': [399], 'acyltransferase': [400], 'cross-links': [402], 'resulting': [404], 'polymerization': [406], '(1Fesus': [407, 538], 'L.': [408, 539, 647, 1171], 'Piacentini': [409, 540], 'M.': [410, 443, 451, 541, 596, 645, 709, 746, 914, 1079, 1139, 4039], 'Trends': [411, 542], 'Biochem.': [412, 456, 543, 714, 751, 919, 1034, 1247, 4044], 'Sci.': [413, 544], '2002;': [414, 545], '27:': [415, 546], '534-539Abstract': [416, 547], 'Full': [417, 419, 510, 512, 548, 550, 669, 671, 973, 975, 1222, 1224, 1319, 1321, 2061, 2063, 2275, 2277, 3986, 3988, 4020, 4022, 4091, 4093, 4150, 4152], 'Text': [418, 420, 511, 513, 549, 551, 670, 672, 974, 976, 1223, 1225, 1320, 1322, 2062, 2064, 2276, 2278, 3987, 3989, 4021, 4023, 4092, 4094, 4151, 4153], 'PDF': [421, 514, 552, 673, 977, 1226, 1323, 2065, 2279, 3990, 4024, 4095, 4154], 'PubMed': [422, 461, 490, 515, 553, 608, 632, 652, 674, 978, 1040, 1091, 1125, 1155, 1227, 1253, 1324, 2066, 2214, 2280, 2449, 3991, 4025, 4096, 4155], 'Scopus': [423, 491, 516, 554, 609, 633, 653, 675, 721, 758, 854, 926, 979, 1041, 1092, 1126, 1156, 1228, 1325, 2067, 2215, 2281, 2450, 3992, 4026, 4051, 4097, 4156], '(485)': [424, 555], 'Google': [425, 462, 493, 518, 556, 611, 635, 655, 677, 723, 760, 856, 928, 981, 1043, 1094, 1128, 1158, 1188, 1230, 1254, 1327, 2069, 2217, 2283, 2452, 3994, 4028, 4053, 4099, 4158], 'Scholar).': [426, 519, 557, 678, 724, 761, 982, 1044, 1095, 1189, 1255, 1328, 2218, 2284, 2453], 'addition,': [428], 'other': [431, 1380, 2989, 4079], 'less': [432], 'characterized': [433], 'functions': [434], 'including': [435, 529], 'as': [436, 464, 496, 833, 1015, 1724, 1942, 2037, 2048, 2073, 2201, 2438, 3029, 3200, 3536, 3797, 3811, 3838], 'protein-disulfide': [438], 'isomerase': [439], '(2Hassegawa': [440], 'G.': [441, 1135, 1141, 1144], 'Suwa': [442], 'Ichikawa': [444], 'Y.': [445, 453, 455, 616, 840, 1175], 'Ohtsuka': [446], 'T.': [447, 477, 1071, 1083, 1306], 'Kumagai': [448], 'S.': [449, 501, 620, 844, 964, 1031, 1081, 1146, 2052, 3977, 4082, 4141], 'Kikuchi': [450], 'Sato': [452], 'Saito': [454], 'J.': [457, 504, 598, 663, 967, 1112, 1149, 1182, 1216, 1246, 1308, 1313, 2055, 2269, 3980, 4014, 4085, 4144], '2003;': [458, 851, 1152, 1185], '373:': [459], '793-803Crossref': [460], 'Scholar),': [463, 636, 857, 929, 1159, 4054, 4159], 'G': [466], 'protein-coupled': [467], 'membrane': [468, 2971], 'receptor': [469], '(3Nakaoka': [470], 'H.': [471, 618, 842, 846, 1069], 'Perez': [472], 'D.M.': [473], 'Baek': [474], 'K.J.': [475], 'Das': [476], 'Husain': [478], 'A.': [479, 626, 1077, 1110, 1133, 1148], 'Misono': [480], 'K.': [481, 1075, 1108], 'Im': [482], 'M.J.': [483, 2258], 'Graham': [484], 'R.M.': [485], 'Science.': [486], '1994;': [487], '264:': [488], '1593-1596Crossref': [489], '(528)': [492], 'Scholar)': [494, 2070, 3995, 4100], '(4Mishra': [500, 963, 2051, 3976, 4081, 4140], 'Murphy': [502, 965, 2053, 3978, 4083, 4142], 'L.J.': [503, 662, 966, 2054, 3979, 4013, 4084, 4143], 'Biol.': [505, 664, 968, 1036, 1217, 1249, 1314, 2056, 2270, 3981, 4015, 4086, 4145], 'Chem.': [506, 665, 850, 969, 1218, 1315, 2057, 2271, 3982, 4016, 4087, 4146], '2004;': [507, 970, 1088, 1122, 1219, 1250, 1316, 2058, 3983, 4088, 4147], '279:': [508, 971, 1220, 1317, 2059, 3984, 4089, 4148], '23863-23868Abstract': [509, 972, 2060, 3985, 4090, 4149], '(166)': [517, 980, 2068, 3993, 4098, 4157], 'It': [520, 1256], 'localized': [522], 'many': [524, 869], 'compartments': [525], 'cell': [528, 531, 1304, 1949, 2164, 2247, 2507, 2514, 3614, 3664, 3752], 'membrane,': [532], 'cytoplasm,': [534], 'nucleus': [537, 588], 'involved': [560], 'multitude': [563], 'cellular': [565], 'process': [566], 'which': [568, 2237, 3560], 'best': [570], 'studied': [571], 'apoptosis': [573, 1059, 1106, 1196], 'where': [574, 637, 2817, 3008], 'responsible': [577, 825, 863, 1063], 'formation': [580], 'apoptotic': [582, 1168], 'bodies.TG2': [583], 'translocated': [585], 'mechanism': [591], 'involves': [593], 'importin-α3': [594], '(5Lesort': [595], 'Tucholski': [597, 1111, 1307], 'Miller': [599, 1202], 'M.L.': [600, 624], 'Johnson': [601, 1113, 1311], 'G.V.': [602, 1114, 1312], 'Prog.': [603], 'Neurobiol.': [604], '2000;': [605], '61:': [606], '439-463Crossref': [607], '(148)': [610], 'Scholar,': [612, 656, 1129, 1231, 4029], '6Peng': [613], 'X.': [614, 1173, 1177, 1179], 'Zhang': [615, 617], 'Graner': [619], 'Williams': [621], 'J.F.': [622], 'Levitt': [623], 'Lokshin': [625], 'FEBS': [627], 'Lett.': [628], '1999;': [629, 2272], '446:': [630], '35-39Crossref': [631], '(71)': [634], 'can': [639, 796, 880, 1192, 4134], 'cross-link': [640, 882, 956], '(7Ballestar': [642], 'E.': [643, 658, 1085, 1310, 4009], 'Boix-Chornet': [644], 'Franco': [646, 661, 4012], 'Biochemistry.': [648], '2001;': [649, 718, 755, 923, 4048], '40:': [650], '1922-1929Crossref': [651], '(28)': [654], '8Ballestar': [657], 'Abad': [659, 4010], 'C.': [660, 1073, 1116, 4011], '1996;': [666, 4017], '271:': [667, 4018], '18817-18824Abstract': [668, 4019], '(100)': [676, 4027], 'Cross-linking': [679], 'core': [682, 984, 1609, 2227, 2553, 2880], 'subunits,': [684], 'H2A': [685, 2579, 2590, 2625, 3717], 'appears': [690, 781, 877], 'involve': [692], 'glutamine': [693], 'lysine': [695], 'residues': [696, 2745, 3561], 'at': [697, 1446, 1463, 1667, 1780, 1803, 1837, 1863, 1925, 1982, 1996, 2353, 2435, 2540, 2820, 2849, 2923, 3045, 3691, 4203], 'COOH-terminal': [698, 2851], 'domain': [699, 2689, 2766], '(9Kim': [700, 737, 905], 'J.H.': [701, 738, 906, 4031], 'Nam': [702, 739, 907, 4032], 'K.H.': [703, 740, 908, 4033], 'Kwon': [704, 741, 909, 4034], 'O.S.': [705, 742, 910, 4035], 'Kim': [706, 743, 911, 1238, 4036], 'I.G.': [707, 744, 912, 4037], 'Bustin': [708, 745, 913, 4038], 'Choy': [710, 747, 915, 4040], 'H.E.': [711, 748, 916, 4041], 'Park': [712, 749, 917, 4042], 'S.C.': [713, 750, 918, 4043], 'Biophys.': [715, 752, 920, 4045], 'Res.': [716, 753, 921, 1151, 2210, 4046], 'Commun.': [717, 754, 922, 4047], '293:': [719, 756, 924, 4049], '1453-1457Crossref': [720, 757, 925, 4050], '(32)': [722, 759, 927, 4052], 'Histone': [725, 2192, 2570, 3356], 'substrate': [734, 3031], 'Histones': [762, 2242], 'bind': [763], 'sequence-independent': [766], 'manner': [767], 'DNA': [769, 814, 818, 830, 2537], 'form': [771], 'chromatin.': [772], 'They': [773], 'subject': [775], 'extensive': [777], 'post-translational': [778], 'modification': [779], 'important': [784, 1269], 'regulating': [786], 'For': [789, 874, 1547, 1710, 1729, 1783, 1840], 'example,': [790, 875], 'amino-terminal': [792], 'tails': [793], 'both': [798], 'acetylated': [801, 1714, 2226, 3170], 'these': [803, 2854, 3417, 3586], 'modifications': [804], 'thought': [806, 3011], 'regulate': [808], 'facilitate': [812], 'transcription,': [813], 'replication,': [815], 'mitosis,': [816], 'repair.Histone': [819], 'cross-linking': [820, 890, 937, 1265, 3870, 3932, 4004], 'may': [823, 1289], 'changes': [828, 1047], 'function': [831], 'such': [832, 1014], 'transcription': [834, 1023], 'replication': [836], '(11Sato': [837], 'N.': [838], 'Ohtake': [839], 'Kato': [841], 'Abe': [843], 'Kohno': [845], 'Ohkubo': [847], 'Y.J.': [848], 'Protein': [849, 1393, 1590], '22:': [852], '303-307Crossref': [853], '(17)': [855], 'although': [858, 1060, 1272], 'exact': [860], 'molecular': [861, 1394, 3517], 'mechanisms': [862], 'not': [865, 896, 932, 2717, 3018, 3425, 3473, 4128, 4185], 'elucidated,': [867], 'apparently': [870], 'contradictory': [871], 'data': [872, 1277, 3275, 3544, 3802, 3948], 'exist.': [873], 'only': [881, 1457, 2638], 'when': [884, 898, 3025, 3707], 'released': [885], 'nucleosome.': [888], 'does': [895], 'occur': [897], 'were': [901, 1347, 1360, 1385, 1397, 1415, 1489, 1516, 1527, 1537, 1553, 1559, 1571, 1611, 1656, 1683, 1694, 1717, 1738, 1753, 1764, 1793, 1809, 1853, 1869, 1880, 1897, 1935, 1972, 1990, 2002, 2010, 2094, 2131, 2169, 2243, 2342, 2395, 2427, 2455, 2470, 2538, 2557, 2596, 2702, 2826, 2934, 3062, 3083, 3169, 3240, 3266, 3276, 3365, 3378, 3394, 3424, 3495, 3503, 3525, 3545, 3564, 3591, 3610, 3634, 3653, 3672, 3721, 3769, 3803, 3865, 3919, 3940, 3953], 'organized': [902], 'immediately': [933], 'obvious': [934], 'how': [935], 'activity': [938, 962, 1266, 3975, 4005, 4126, 4161, 4174], 'could': [941], 'modulate': [942], 'gene': [943, 1022], 'transcription.We': [944], 'addition': [951, 1510, 1675, 2459], 'its': [953, 1299], 'ability': [954], 'The': [983, 1283, 1670, 1988, 2219, 2368, 2513, 2663, 2677, 2786, 2843, 3162, 3374, 3390, 3513, 3780, 3934, 4110, 4124], 'histones,': [985, 1008, 3999, 4198], 'H4,': [990], 'phosphorylated,': [998, 2825], 'suggested': [1003], 'certain': [1007], 'example': [1010], 'kinases': [1013, 4080], 'mitogen-': [1016], 'stress-induced': [1018], 'kinase,': [1019], 'MSK1,': [1020], 'promotes': [1021], '(12Dunn': [1024], 'K.L.': [1025, 2442], 'Espino': [1026], 'P.': [1027], 'Drobic': [1028], 'B.': [1029], 'He': [1030], 'Davie': [1032, 2206, 2267, 2443], 'J.R.': [1033, 2207, 2268, 2444], 'Cell': [1035, 1119, 1357], '2005;': [1037, 2446], '83:': [1038], '1-14Crossref': [1039], '(191)': [1042], 'Furthermore,': [1045], 'rapid': [1046], 'patterns': [1051], 'documented': [1055], 'after': [1056, 1847, 2511], 'induction': [1057], 'enzymes': [1062], 'remain': [1064, 2231], 'unknown': [1065], '(13Enomoto': [1066], 'R.': [1067, 1118, 1131], 'Tatsuoka': [1068], 'Komai': [1070], 'Sugahara': [1072], 'Takemura': [1074], 'Yamauchi': [1076], 'Nishimura': [1078], 'Naito': [1080], 'Matsuda': [1082], 'Lee': [1084, 1234], 'Neurochem.': [1086], 'Int.': [1087], '44:': [1089], '459-467Crossref': [1090], '(15)': [1093], 'activated': [1098], 'variety': [1101], 'agents': [1103], 'induce': [1105], '(14Robitaille': [1107], 'Daviau': [1109], 'Rancourt': [1115], 'Blouin': [1117], 'Death': [1120], 'Differ.': [1121], '11:': [1123], '542-549Crossref': [1124], '(31)': [1127], '15Ientile': [1130], 'Campisi': [1132], 'Raciti': [1134], 'Caccamo': [1136], 'D.': [1137], 'Curro': [1138], 'Cannavo': [1140], 'Li': [1142, 1174], 'Volti': [1143], 'Macaione': [1145], 'Vanella': [1147], 'Neurosci.': [1150], '74:': [1153], '52-59Crossref': [1154], '(51)': [1157], 'null': [1162], 'relatively': [1165], 'resistant': [1166], 'stimuli': [1169], '(16Song': [1170], 'Ma': [1172], 'Cui': [1176], 'Wang': [1178], 'Chin.': [1180], 'Med.': [1181], '(Engl.': [1183], 'Ed.).': [1184], '116:': [1186], '742-746PubMed': [1187], 'However,': [1190, 3429, 3892], 'protect': [1194], 'against': [1195], 'under': [1197, 2561], 'some': [1198, 1534], 'circumstances': [1199], '(17Antonyak': [1200], 'M.A.': [1201], 'A.M.': [1203], 'Jansen': [1204], 'J.M.': [1205], 'Boehm': [1206], 'J.E.': [1207], 'Balkman': [1208], 'C.E.': [1209], 'Wakshlag': [1210], 'J.J.': [1211], 'Page': [1212], 'R.L.': [1213], 'Cerione': [1214], 'R.A.': [1215], '41461-41467Abstract': [1221], '(99)': [1229], '18Kweon': [1232], 'S.M.': [1233], 'Z.W.': [1235], 'Yi': [1236], 'S.J.': [1237], 'Y.M.': [1239], 'Han': [1240], 'J.A.': [1241, 2205, 2266], 'Paik': [1242], 'S.G.': [1243], 'Ha': [1244], 'S.S.': [1245], 'Mol.': [1248], '37:': [1251], '185-191Crossref': [1252], 'assumed': [1259], 'apoptosis,': [1271], 'there': [1273, 2738], 'few': [1275], 'experimental': [1276, 3888], 'directly': [1279], 'test': [1280], 'hypothesis.': [1282], 'different': [1284, 1300], 'functional': [1285], 'roles': [1286], 'related': [1291], 'activation': [1293], 'state': [1294], 'coenzymes,': [1297], 'or': [1298, 1408, 1605, 1700, 2173, 2182, 2722, 3057, 3071, 3244, 3532, 3927], 'localization': [1301], 'within': [1302], '(19Milakovic': [1305], 'McCoy': [1309], '8715-8722Abstract': [1318], '(98)': [1326], 'report': [1331], 'activity.MATERIALS': [1341], 'AND': [1342], 'METHODSReagents—MCF-7': [1343], 'COS-1': [1345, 1948, 3663, 3755, 3832], 'obtained': [1348, 1386, 3277, 3804], 'American': [1351], 'Type': [1352], 'Collection': [1354], '(Manassas,': [1355], 'VA).': [1356], 'culture': [1358, 2098], 'reagents': [1359], 'Invitrogen': [1362], '(Burlington,': [1363], 'Ontario,': [1364, 1391, 1401], 'Canada).': [1365, 1392], 'Recombinant': [1366], 'human': [1367, 1422, 2090, 4169], 'expressed': [1369, 1584, 4114, 4168], 'insect': [1371, 4116], 'cells,': [1372], 'purchased': [1374], 'Roboscreen': [1376], '(Leipzig,': [1377], 'Germany).': [1378], 'All': [1379], 'reagents,': [1381], 'unless': [1382], 'otherwise': [1383], 'stated,': [1384], 'Sigma': [1388], 'Canada': [1389], '(Oakville,': [1390], 'weight': [1395, 3518], 'markers': [1396, 3519], 'Bio-Rad': [1399], '(Mississauga,': [1400], 'Canada).In': [1402], 'Vitro': [1403, 1589], 'Phosphorylation': [1404], 'Assay—Recombinant': [1405], 'NH2-terminal': [1409, 1606, 1890, 2612, 3680], 'peptides': [1410, 1552, 1570, 1607, 1737, 2701, 2779, 2855, 2933, 3061, 3113, 3131, 3159, 3168, 3230, 3239, 3310, 3652, 3720, 3732], '(obtained': [1411], 'Upstate': [1413, 1800], 'Biotechnology)': [1414, 1478, 1801, 1896], 'incubated': [1416, 1496, 1612, 1663, 1771, 1794, 1827, 1854, 1898, 1978, 2343, 2428, 2518, 2827, 2935, 3242, 3366, 3496, 3526, 3673, 3758], 'separately': [1417], '0.25': [1419, 1640], 'μg': [1420, 1641, 1894], 'recombinant': [1423, 1603, 1614, 3054, 4111], 'buffer': [1427, 1622, 1910, 1941, 1953, 2020, 2314, 2476, 3371], '(50': [1428, 1623, 1911, 1954, 2315], 'mm': [1429, 1434, 1624, 1651, 1816, 1819, 1912, 1917, 1955, 1960, 1963, 2240, 2316, 2319, 2462], 'Tris-HCl,': [1430, 1625, 1913, 1956, 2317], 'pH': [1431, 1626, 1824, 1914, 1957, 2321, 2493], '7.5,': [1432, 1627], '10': [1433, 1650, 2176, 2239, 2433, 2822], 'magnesium,': [1435], '50': [1436, 1629, 1653, 2301, 2327], 'μm': [1437, 1630, 1654, 1967], 'ATP,': [1438], '[γ-32P]ATP': [1440, 1647, 2831, 2939, 3070, 3528], '(60': [1441], 'μCi/ml))': [1442], '30': [1444, 1447, 1665, 1668, 1994, 2016, 2188], 'min': [1445, 1499, 1520, 1666, 1687, 2014, 2181, 2434], '°C.': [1448, 1669, 1805, 1927], 'To': [1449, 2285], 'study': [1450, 1593], 'effect': [1452, 1595, 3105, 3122, 3149, 3204, 3298], 'on': [1455, 1523, 1555, 1598, 1755, 2397, 2869, 3102, 3114, 3123, 3153, 3205, 3303, 3316, 3333, 3380, 3398, 3505, 3547, 3794], 'acetylation': [1456, 1597, 3109, 3190, 3207, 3215, 3302, 3315], 'cold': [1458], 'ATP': [1459, 1655, 3072, 3252], 'used,': [1461], 'end': [1465, 1637, 1930, 2357, 2852], 'protocol,': [1469], 'p300,': [1470, 1615], 'acetyltransferase': [1472], '(HAT)': [1473], 'domain,': [1474, 1617], '0.4': [1475, 1618, 2250], 'μg,': [1476, 1619], '(Upstate': [1477, 1895], '90': [1480], 'pmol': [1481], '[3H]acetyl-CoA': [1483], '(1–10': [1484], 'Ci/mmol,': [1485], 'PerkinElmer': [1486], 'Life': [1487, 1722], 'Sciences)': [1488, 1723], 'added': [1490, 1657, 1973, 3470, 3830], 'tubes': [1493, 1660, 1989], 'further': [1495, 1662], '30–45': [1498, 1633], 'final': [1502], '40': [1503, 2345], 'μl': [1504, 1901, 1907, 1946, 2017, 2302, 2328, 2346], 'volume.': [1505], 'Reaction': [1506], 'stopped': [1508, 1673], 'SDS-PAGE': [1512, 1677, 1757, 2024, 2944, 3077, 3383, 3508, 3637, 3772, 3875], 'sample': [1513, 1678], 'buffer.': [1514, 2332], 'Samples': [1515, 3633], 'boiled': [1517, 1684, 2011], '5': [1519, 1686], 'analyzed': [1522, 1543, 1689, 1706, 1870, 2022, 2597, 2942, 3075, 3084, 3635, 3770, 3837, 3873], 'SDS-PAGE.': [1524, 1691], 'Subsequently,': [1525, 1692], 'gels': [1526, 1558, 1693, 1716, 3082], 'dried': [1528, 1695], 'processed': [1530, 1697, 2378, 2405], 'autoradiography.': [1532, 2946, 3079], 'cases': [1535], 'transferred': [1538, 1701, 1759, 2399, 3402], 'nitrocellulose': [1540, 1703, 1761, 2402, 3404], 'membranes': [1541, 1704, 1792, 1808, 1852, 1868], 'Western': [1545, 1708, 1750, 2027, 2407], 'blot.': [1546, 1709], 'quantification': [1548, 1730], 'separated': [1554, 1754, 2396, 3379, 3504], 'SDS-PAGE,': [1556, 2398], 'stained': [1560], 'Coomassie': [1562, 3387], 'Blue.': [1563], 'Bands': [1564], 'corresponding': [1565, 1734], 'excised': [1572, 3395], 'radioactivity': [1575, 1732, 1742], 'measured': [1576, 1744], 'β': [1579, 1747], 'counter.': [1580], '[32P]Phosphate': [1581], 'incorporated': [1582, 3442], 'per': [1585, 1725], 'picomole': [1586], 'substrate.In': [1588], 'Acetylation': [1591, 3101, 3119], 'Assay—To': [1592], 'phosphorylation,': [1599], '500': [1600, 1906, 1945], 'ng': [1601], 'protein': [1604, 2044, 2591, 2608, 2646, 2750, 3056, 3827], 'HAT': [1616, 3257, 3300], 'reaction': [1621, 1671, 4075], 'containing': [1628, 2100, 2140, 3372], 'acetyl-CoA)': [1631], 'min.': [1634], 'At': [1635, 1928, 2355], 'reaction,': [1639], '60': [1645], 'μCi/ml': [1646], 'along': [1648], 'MgCl2,': [1652], 'buffer,': [1679, 2236, 2492, 2532], 'samples': [1682], 'autoradiography': [1699, 1711, 3409], 'EN3HANCE': [1720], '(PerkinElmer': [1721], "manufacturer's": [1727], 'protocol.': [1728], 'bands': [1733, 3377, 3393], 'excised,': [1739, 3510], 'counter.Western': [1748], 'Blotting—For': [1749], 'blotting,': [1751], '16%': [1756, 3382, 3507], 'membranes.': [1762], 'Membranes': [1763], 'blocked': [1765], '5%': [1767, 1850, 2105, 2123, 2147], 'milk': [1768], 'then': [1770, 1991, 2517], 'respective': [1774], 'primary': [1775, 1797], '1': [1778, 1835, 1861, 1923, 2351], 'h': [1779, 1836, 1862, 1924, 1981, 2352], 'room': [1781, 1838, 1864, 2436], 'temperature.': [1782, 1839, 1865], 'detection': [1784], 'specific': [1789, 2290], 'amino': [1790, 2291], 'acid': [1791, 2253], '(1:500,': [1799], 'overnight': [1802], '4': [1804, 1926, 1983], 'After': [1806, 1866, 2467, 2526, 3763], 'incubation,': [1807, 1932, 2360], 'washed': [1810, 1936, 2003, 2309], 'three': [1811, 1937, 2310, 2374, 2527, 3887], 'times': [1812, 1938, 2005, 2311], 'TBST': [1814], '(10': [1815, 2156], 'Tris,': [1817], '150': [1818, 1916, 1959], 'NaCl,': [1820, 1918, 1961, 2320, 2486], '0.05%': [1821], 'Tween': [1822], '20,': [1823], '8.0)': [1825, 2322], 'peroxidase': [1830], '(HRP)-conjugate': [1831], 'secondary': [1832], 'blotting': [1841], 'biotinylated': [1844, 2047, 3746, 3822], 'peptides,': [1846, 1892], 'blocking': [1848], 'milk,': [1851], 'streptavidin-HRP': [1856, 2035, 2864, 3269, 3786], 'conjugate': [1857, 2306], '(1:10,000': [1858], 'dilutions)': [1859], 'washing': [1867], 'ECL': [1872], 'reagent': [1873], 'Amersham': [1875], 'Biosciences.Streptavidin-Agarose': [1876], 'Pull-down': [1877], 'Assay—COS-1': [1878], 'cultured': [1881], 'DMEM': [1883, 2101, 2138], '10%': [1885], 'fetal': [1886, 2106], 'calf': [1887], 'serum.': [1888], 'Biotinylated': [1889], '20': [1900], 'streptavidin-agarose': [1903, 3765], '(Sigma)': [1904, 2045, 2139, 2307], 'Tris-HCl': [1909, 1940, 1952], '8.0,': [1915, 1958], '0.5%': [1919, 1969], 'Nonidet': [1920, 1970], 'P-40)': [1921, 1971], 'agarose': [1933], 'beads': [1934], 'described': [1943, 2038, 2049, 2202, 2439], 'above.': [1944, 2039], 'lysate': [1950, 2508, 2515], '0.5': [1962], 'phenylmethylsulfonyl': [1964], 'fluoride,': [1965], '0.3': [1966], 'aprotinin,': [1968], 'each': [1975, 3261], 'tube': [1976], '°C': [1984, 2119, 2542], 'constant': [1986], 'stirring.': [1987], 'centrifuged': [1992], 's': [1995], '7000': [1997], 'rpm,': [1998], 'pellets': [2001, 2248, 3768], 'five': [2004], 'Tris-buffered': [2007], 'saline.': [2008, 2466], 'Pellets': [2009], '8': [2013], 'Laemmli': [2019], 'followed': [2025], 'blot': [2028, 2859], 'using': [2029, 2409, 3087, 3160, 3576, 3593, 3929], 'goat': [2030], 'polyclonal': [2031], 'anti-transglutaminase': [2032], '(1:1000)': [2033], '(1:7500)': [2036], 'Guinea': [2040], 'pig': [2041, 3824], 'myelin': [2042, 3740, 3825], 'basic': [2043, 2082, 3741, 3820, 3826], 'previously': [2050, 2203, 2440, 4064], 'included': [2072, 3793], 'control': [2075, 3538, 3813, 3858], 'nonspecific': [2077, 3815], 'interaction': [2078, 3213, 3658, 3736, 3816], 'proteins.Cell': [2083], 'Culture': [2084], 'Treatments—Hormone-dependent,': [2086], 'estrogen': [2087], 'receptor-positive': [2088], 'carcinoma': [2092], 'maintained': [2095], 'complete': [2097], 'medium': [2099], '(Invitrogen)': [2102], 'supplemented': [2103], 'bovine': [2107, 2150], 'serum,': [2108], 'penicillin': [2109, 2141], '(100': [2110, 2114, 2142, 2145, 2387, 2391], 'units/ml),': [2111, 2143], 'streptomycin': [2113, 2144], 'μg/ml)': [2115, 2157], '37': [2118], 'humidified': [2120], 'incubator': [2121], 'CO2.': [2124], 'Once': [2125], '60–70%': [2126], 'confluence': [2127], 'reached,': [2129], 'estrogen-': [2132], 'serum-depleted': [2134], 'phenol': [2136], 'red-free': [2137], 'μg/ml),': [2146], 'glucose,': [2148], '0.1%': [2149], 'serum': [2151], 'albumin': [2152], '(Sigma),': [2153], 'apotransferrin': [2155], 'drive': [2159], 'majority': [2161, 2650, 2678], 'population': [2165], 'G0/G1.': [2167], 'Cells': [2168], 'either': [2170], 'left': [2171], 'untreated': [2172], 'nm': [2177, 2185], 'E2': [2178, 3926], '45': [2180], '100': [2184], 'TPA': [2186, 3928], 'min.Nucleosome': [2189], 'Preparation': [2190], 'Isolation—Chicken': [2193], 'immature': [2194], 'erythrocyte': [2195], 'salt-soluble': [2196, 2220], 'S150': [2198], 'prepared': [2200, 2337, 2510, 3611, 3866, 3920], '(20Ridsdale': [2204], 'Nucleic': [2208], 'Acids': [2209], '1987;': [2211], '15:': [2212], '1081-1096Crossref': [2213], '(74)': [2216], 'fragments': [2222, 2774, 3361], 'enriched': [2224], 'will': [2230], 'soluble': [2232], 'contains': [2238, 3004], 'MgCl2.': [2241], 'isolated': [2244], 'n': [2251], 'H2SO4': [2252], 'extraction': [2254], '(21Chadee': [2255], 'D.N.': [2256], 'Hendzel': [2257], 'Tylipski': [2259], 'C.P.': [2260], 'Allis': [2261], 'C.D.': [2262], 'Bazett-Jones': [2263], 'D.P.': [2264], 'Wright': [2265], '274:': [2273], '24914-24920Abstract': [2274], '(244)': [2282], 'determine': [2286, 3559], 'acids': [2292], 'present': [2297, 3722], 'nucleosome,': [2300], 'agarose-alkaline': [2304], 'phosphatase': [2305, 3621], 'incubation': [2313, 3255, 3582, 3628], '120': [2318], 'finally': [2324], 'resuspended': [2325, 2473], 'same': [2331, 2970, 3264], 'Five': [2333], 'micrograms': [2334], 'nucleosomes': [2336, 3494, 3524], 'serum-starved': [2339], 'enzyme': [2349, 2363], '37°C.': [2354], 'immobilized': [2362, 3577, 3619], 'removed': [2365], 'centrifugation.': [2367, 2512], 'supernatant': [2369], 'collected,': [2371], 'divided': [2372], 'into': [2373, 2760, 2879, 2961, 3137, 3443], 'tubes,': [2375], 'subsequently': [2377, 2941, 3074, 3783], 'TG2-induced': [2380, 2681, 2757, 3103, 3151, 3187, 3217, 3221], 'presence': [2384, 2844, 3068, 3249, 3531, 3935], 'NaF': [2386], 'mm)': [2388], 'Na3VO4': [2390], 'mm).': [2392], 'Phosphorylated': [2393], 'membranes,': [2403], 'immunoblot': [2408], 'phospho-specific': [2410], 'antibodies.Isolation': [2411], 'Proteins': [2414], 'Formaldehyde': [2416], 'Cross-linking—After': [2417], 'treatments': [2418], 'indicated': [2419, 3882], 'above,': [2420], '∼1': [2421], '×': [2422], '109': [2423], '1%': [2430], 'formaldehyde': [2431, 3869, 3931], 'temperature': [2437], '(22Dunn': [2441], 'Oncogene.': [2445], '24:': [2447], '3492-3502Crossref': [2448], '(64)': [2451], 'Reactions': [2454], 'quenched': [2456], '125': [2461], 'glycine': [2463], 'phosphate-buffered': [2465], 'washing,': [2468], 'collected': [2471], 'lysis': [2475, 2531], '(5': [2477], 'm': [2478, 2481, 2485, 2489], 'urea,': [2479], 'guanidine': [2482], 'hydrochloride,': [2483], '0.2': [2488], 'potassium': [2490], 'phosphate': [2491, 2620, 2710, 2805, 2878, 3135, 3439], '7.5).': [2494], 'Sonication': [2495], 'carried': [2497], 'out': [2498], 'solubilize': [2500], 'hydroxyapatite': [2520], '(Bio-Rad)': [2521], '(1': [2522], 'g': [2523], 'hydroxyapatite/80A260).': [2525], 'washes': [2528], 'ice-cold': [2530], 'reversed': [2539], '65': [2541], 'over': [2544], '6': [2545], 'h,': [2546], 'dialyzed,': [2547], 'lyophilized.RESULTSTG2': [2549], 'Phosphorylates': [2550, 3355], 'Histones—All': [2551], 'four': [2552, 3950, 4197], 'vitro': [2563, 4189], 'conditions': [2564, 3418, 3889, 4190], '(Fig.': [2565, 2580, 2627, 2726, 2751, 2841, 2872, 3022, 3040, 3140, 3171, 3414, 3446, 3483, 3596, 3701, 3733, 3890, 3906], '1,': [2566, 2727], 'A': [2567, 2769, 3220, 3435, 3789], 'C).': [2569, 2730], 'H2B': [2571, 2645, 2656, 3719], 'more': [2573, 2791, 3716], 'highly': [2574], 'than': [2578, 2794, 4121], '1A': [2581, 2628], 'Table': [2583, 2630, 3143, 3287], '1).': [2584, 2631, 2691, 2768, 3428], 'When': [2585, 2807, 2947], 'equal': [2586, 2978, 3272], 'molar': [2587], 'amounts': [2588, 2809, 2928, 3052, 3236, 3669], 'H2A1–21': [2594, 2787, 3128], 'fragment': [2595, 2636, 2666, 2735], 'level': [2599, 2803], 'label': [2601, 2848], 'incorporation': [2602, 2621, 2707, 2759, 2876, 2949, 3136, 3176], '4-fold': [2604], 'greater': [2605, 4120], 'compared': [2609, 2641, 3727], 'suggesting': [2614], 'additional': [2616, 2744], 'sites': [2617, 2991], 'occurred': [2622, 2685, 2762, 4202], 'throughout': [2623], 'molecule': [2626], 'contrast,': [2633], 'H2B1–21': [2635, 2798, 3130, 3183], 'lightly': [2639], 'radiolabeled': [2640, 2703, 3134], 'indicating': [2647, 2704, 3458], 'labeling': [2653, 2834, 3155], 'occurring': [2658], 'elsewhere': [2659, 2746], 'protein.': [2662], 'H31–21': [2665, 2734, 2765, 2778, 2811, 2930, 2956, 3058, 3139, 3193], 'H321–44': [2673, 3016, 3060], 'not.': [2676], 'H41–21': [2688], '(Table': [2690, 2767, 3185, 3197, 3427], 'absence': [2694, 3450, 3533], 'none': [2697], 'group': [2711], 'due': [2713, 3467, 3474, 4129], 'result': [2719], 'autophosphorylation': [2721], 'contaminating': [2724, 3477], 'B': [2728], 'Although': [2731], 'evidence': [2740], '1B).': [2752], 'Approximately': [2753], 'one-third': [2754], '32P': [2758, 2951, 2960], 'comparison': [2770], 'H2A1–21,': [2775, 3163], 'H2B1–21,': [2776], 'Fig.': [2784], '1D.': [2785], 'slightly': [2790], 'strongly': [2792], 'labeled': [2793], 'H31–21,': [2795, 3164], 'showed': [2800], 'lowest': [2802], 'incorporation.': [2806], 'equivalent': [2808, 2867], 'S10P-H31–21': [2815, 2837, 2932, 2963, 3167, 3210], 'peptide,': [2816, 3001], 'serine': [2819], 'position': [2821, 3514], 'already': [2824], 'very': [2832], 'little': [2833, 3175], 'observed': [2840, 3457], '2A).': [2842], 'biotin': [2847], 'allowed': [2856], 'probed': [2862, 2973, 3267], 'demonstrate': [2866, 2977, 3271, 3997], 'loading': [2868], 'gel': [2871, 3401, 3709, 3796, 4181], '2B).TABLE': [2873], '1TG2': [2874], 'catalyzed': [2875], 'N-terminal': [2884, 3309], 'peptidesSubstrate[32P]Phosphate': [2885], 'incorporatedpmol/pmol': [2886, 3318, 3335], 'substrateH1': [2888], 'protein1.42H2A': [2889], 'protein1.31H2A1-21': [2890], 'peptide0.32H2B': [2891], 'protein1.50H2B1-21': [2892], 'peptide0.03H3': [2893], 'protein0.94H31-21': [2894], 'peptide0.27H321-44': [2895], 'peptide0.01H4': [2896], 'protein1.08H4': [2897], '1-21': [2898], 'peptide0.91H1': [2899], 'nucleosome0.29H2A': [2901], 'nucleosomeNot': [2903, 2906, 2911], 'detectedH2B': [2904], 'detectedH3': [2907], 'nucleosome1.26H4': [2909], 'detected': [2912, 3036, 3941], 'Open': [2913, 3348], 'table': [2914, 3349], 'new': [2917, 3352], 'tab': [2918, 3353], 'FIGURE': [2919], '2TG2': [2920], 'phosphorylates': [2921, 3043, 3486, 3599], 'Ser10.': [2924], 'A,': [2926, 3493, 3750], 'equimolar': [2927, 3235], 'quantified,': [2948], '∼0.3': [2953], 'pmol/pmol': [2954], 'peptide.': [2957], 'Incorporation': [2958], 'unmeasurable.': [2966], 'B,': [2968, 3234, 3523, 3810], 'streptoavidin-HRP': [2975], 'loading.View': [2979], 'Large': [2980, 3092, 3289, 3551, 3640, 3840, 3957], 'Image': [2981, 3093, 3290, 3552, 3641, 3841, 3958], 'Figure': [2982, 3094, 3291, 3553, 3642, 3842, 3959], 'ViewerDownload': [2983, 3095, 3292, 3554, 3643, 3843, 3960], 'Hi-res': [2984, 3096, 3293, 3555, 3644, 3844, 3961], 'image': [2985, 3097, 3294, 3556, 3645, 3845, 3962], 'Download': [2986, 3098, 3295, 3557, 3646, 3846, 3963], '(PPT)To': [2987, 3558], 'identify': [2988], 'potential': [2990], 'TG2-mediated': [2993], 'examine': [2998, 3656], 'another': [2999, 3006], 'H321–44,': [3002], 'Ser28': [3005, 3034, 3049, 3590, 3603], 'residue': [3007], 'functionally': [3014], 'important.': [3015], '1A);': [3023], 'however,': [3024], 'antibody': [3039, 3881, 4139], '3).FIGURE': [3041], '3TG2': [3042], '(S10)': [3047, 3601], '(S28).': [3050], 'Equimolar': [3051], 'Simultaneously': [3080], 'run': [3081], 'immunoblotting': [3086, 3774], 'antiphospho-Ser10': [3088], 'antiphospho-Ser28': [3090], 'antibody.View': [3091], '(PPT)Effects': [3099], 'Phosphorylation—The': [3104], 'p300': [3107], 'HAT-induced': [3108, 3154], 'examined.': [3118, 3232], 'had': [3120, 3202], 'no': [3121, 3203, 3453], 'but': [3132], '4A': [3141], '2).': [3144, 3186], 'next': [3146], '[3H]acetyl-CoA.': [3161, 3259], '4B).': [3172], 'contrast': [3174], 'radiolabel': [3178], 'seen': [3180], '∼2-fold': [3196], '2)': [3198], 'but,': [3199], 'anticipated,': [3201], 'peptide.FIGURE': [3211], 'phosphorylation.': [3218], 'non-acetylated': [3224], 'HAT-acetylated': [3226], 'H2': [3227], 'initially': [3241, 3571], 'without': [3245], 'unlabeled': [3251], 'prior': [3253, 3580, 3626], 'case': [3262], 'filters': [3265], 'loading.': [3273], 'Similar': [3274, 3801], 'separate': [3280, 3549, 3807, 3951], 'experiment': [3281], 'quantified': [3285, 3954], '2.View': [3288], '(PPT)TABLE': [3296], '2The': [3297], 'induced': [3301], 'mediated': [3305], 'vice': [3312], 'versaEffect': [3313], 'phosphorylationSubstrate[32P]Phosphate': [3317], 'substrateH2A1-21': [3320, 3337], '(NA)0.32H2A1-21': [3321], '(A)0.34H2B1-21': [3322], '(NA)0.12H2B1-21': [3323], '(A)0.10H31-21': [3324], '(NA)0.32H31-21': [3325], '(A)0.05S10P': [3326], 'H31-21': [3327, 3329, 3344, 3346], '(NA)0.02S10P': [3328], '(A)0.01Effect': [3330], 'acetylation[3H]Acetate': [3334], '(NP)0.36H2A1-21': [3338], '(P)0.33H2B1-21': [3339], '(NP)0.01H2B1-21': [3340], '(P)0.02H31-21': [3341], '(NP)0.56H31-21': [3342], '(P)1.21S10P': [3343], '(NP)0.29S10P': [3345], '(P)0.31': [3347], 'Nucleosomes—Salt-soluble': [3359], 'avian': [3363], 'erythrocytes': [3364], '[γ-32P]ATP.': [3373, 3500], 'major': [3375], 'identified': [3385, 3407, 3592], 'Blue': [3388], 'staining.': [3389], 'individual': [3391], 're-run': [3397], 'similar': [3400, 3883], 'paper': [3405], 'Ponceau': [3411], 'S': [3412], 'staining': [3413], '5A).': [3415, 3447], 'Under': [3416, 3585, 4187], 'intensely': [3433], 'radiolabeled.': [3434], 'small': [3436], 'amount': [3437], 'preparation': [3482, 3569, 3575], '5B).FIGURE': [3484], '5TG2': [3485], 'nucleosomes.': [3491, 3608], 'Individual': [3501], 'gel,': [3509], 're-analyzed.': [3512], 'indicated.': [3521], 'endogenous': [3540, 3624], 'replicated': [3546], 'occasion.View': [3550], 'dephosphorylated': [3572], 'alkaline': [3578, 3620], 'phosphophase': [3579], 'TG2.': [3584, 3694], 'condition': [3587], '6).FIGURE': [3597], '6TG2': [3598], '(S28)': [3604], 'Nucleosomes': [3609], 'nuclei': [3615], 'reduce': [3623], 'ATP.': [3632], 'immunoblotting.View': [3639], '(PPT)TG2': [3647, 3847], 'Interacts': [3648], 'Histones—Biotinylated': [3650], 'histones.': [3662], 'extracts': [3665], 'contain': [3667], 'large': [3668], 'peptides.': [3681, 3748, 3762], 'assay': [3684, 4183], 'most': [3689], 'efficient': [3690, 3700], 'pulling': [3692], 'down': [3693], 'least': [3699], '7a).': [3702], 'This': [3703], 'particularly': [3705], 'apparent': [3706, 3738, 4164], 'reprobed': [3711], 'streptavidin-HRP,': [3713], 'demonstrating': [3714], 'pulled': [3725], 'downs': [3726], '7B).': [3734], 'No': [3735], 'protein.FIGURE': [3742], '7TG2': [3743], 'binds': [3744], 'whole': [3751], 'extract': [3753], 'various': [3761], 'pull-down': [3766], 'anti-TG2': [3776, 4138], 'anti-sera': [3777], '(upper': [3778], 'panel).': [3779, 3788], 'filter': [3781], 're-probed': [3784], '(lower': [3787], 'standard': [3791], 'positive': [3799], 'control.': [3800], 'experiment.': [3808], 'guinea': [3823], '(MBP)': [3828], 'extracted': [3835], 'above.View': [3839], 'Is': [3848], 'Associated': [3849], 'Chromatin': [3851], 'Cells—DNA': [3854], 'E2-': [3860], 'technique': [3871], 'immunoblotting.': [3877, 3943], 'Probing': [3878], 'anti-H3': [3880], 'all': [3886, 4196], '8A).': [3891], '8B).FIGURE': [3907], '8Detection': [3908], 'technique.': [3933], 'lower': [3946], 'panel': [3947], 'experiments': [3952], 'densitometry.View': [3956], '(PPT)DISCUSSIONHere': [3964], 'extend': [3966], 'our': [3967], 'previous': [3968], 'observations': [3969], '(8Ballestar': [4008], '9Kim': [4030], 'Km': [4068], 'Vmax': [4070], 'comparable': [4077], 'thus': [4102], 'likely': [4104], 'physiologically': [4106], 'relevant': [4107], 'vivo.': [4109], '90%': [4122], 'pure.': [4123], 'combination,': [4131], 'since': [4132], 'immunoprecipitated': [4136], 'Escherichia': [4166], 'coli': [4167], 'co-migrates': [4175], 'an': [4179], '(data': [4184], 'shown).': [4186]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1968240129', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 8}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2025-01-08T15:38:55.528118', 'created_date': '2016-06-24'}
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