Regorafenib (BAY 73‐4506): A new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity

Name: Work Video:
Duration: 3 min 30 s
Scott M. Wilhelm; Jacques Dumas; Lila Adnane; Mark Lynch; Christopher A. Carter; Gunnar Schütz; Karl‐Heinz Thierauch; Dieter Zopf
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241], 'the': [36, 82, 114, 119, 133, 141, 201], 'biology': [37], 'normal': [39], 'vasculature.': [42], 'Regorafenib': [43, 105, 173], '(BAY': [44], '73-4506),': [45], 'novel': [47], 'oral': [48], 'multikinase': [49, 229], 'inhibitor,': [50], 'potently': [51], 'inhibits': [52, 66], 'these': [53], 'cell': [55], 'kinases': [56, 69, 85, 217], 'biochemical': [58], 'cellular': [60], 'phosphorylation': [62], 'assays.': [63], 'Furthermore,': [64], 'regorafenib': [65, 94, 223], 'additional': [67], 'angiogenic': [68], '(VEGFR1/3,': [70], 'platelet-derived': [71], 'receptor-β': [74], 'fibroblast': [76], '1)': [80], 'mutant': [83], 'oncogenic': [84], 'KIT,': [86], 'RET': [87], 'B-RAF.': [89], 'The': [90], 'antiangiogenic': [91], 'effect': [92], 'was': [95, 158], 'demonstrated': [96], 'vivo': [98], 'dynamic': [100], 'contrast-enhanced': [101], 'magnetic': [102], 'resonance': [103], 'imaging.': [104], 'administered': [106], 'once': [107], 'orally': [108, 227], 'at': [109, 168], '10': [110, 169], 'mg/kg': [111], 'significantly': [112], 'decreased': [113], 'extravasation': [115], 'Gadomer': [117], 'vasculature': [120], 'rat': [122], 'GS9L': [123], 'glioblastoma': [124], 'xenografts.': [126], 'In': [127], 'daily': [129], '(qd)×4': [130], 'dosing': [131, 143, 167], 'study,': [132], 'pharmacodynamic': [134], 'effects': [135], 'persisted': [136], 'for': [137], '48': [138], 'hr': [139], 'after': [140, 165], 'last': [142], 'correlated': [145], 'inhibition': [149], '(TGI).': [150], 'A': [151], 'significant': [152], 'reduction': [153, 206], 'microvessel': [156], 'area': [157], 'observed': [159, 189], 'human': [162, 181, 242], 'colorectal': [163], 'xenograft': [164, 182], 'qd×5': [166], '30': [171], 'mg/kg.': [172], 'exhibited': [174], 'potent': [175], 'dose-dependent': [176], 'TGI': [177], 'various': [179], 'preclinical': [180], 'models': [183], 'mice,': [185], 'shrinkages': [188], 'breast': [191, 202], 'MDA-MB-231': [192], 'renal': [194], '786-O': [195], 'carcinoma': [196], 'models.': [197], 'Pharmacodynamic': [198], 'analyses': [199], 'model': [203], 'revealed': [204], 'strong': [205], 'staining': [208], 'proliferation': [210], 'marker': [211], 'Ki-67': [212], 'phosphorylated': [214], 'extracellular': [215], 'regulated': [216], '1/2.': [218], 'These': [219], 'data': [220], 'demonstrate': [221], 'that': [222, 236], 'well-tolerated,': [226], 'active': [228], 'inhibitor': [230], 'distinct': [233], 'target': [234], 'profile': [235], 'may': [237], 'have': [238], 'therapeutic': [239], 'benefit': [240], 'malignancies.': [243]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1968209756', 'counts_by_year': [{'year': 2024, 'cited_by_count': 86}, {'year': 2023, 'cited_by_count': 96}, {'year': 2022, 'cited_by_count': 116}, {'year': 2021, 'cited_by_count': 124}, {'year': 2020, 'cited_by_count': 123}, {'year': 2019, 'cited_by_count': 112}, {'year': 2018, 'cited_by_count': 92}, {'year': 2017, 'cited_by_count': 94}, {'year': 2016, 'cited_by_count': 81}, {'year': 2015, 'cited_by_count': 72}, {'year': 2014, 'cited_by_count': 89}, {'year': 2013, 'cited_by_count': 69}, {'year': 2012, 'cited_by_count': 32}], 'updated_date': '2024-12-20T02:23:59.907402', 'created_date': '2016-06-24'}
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