Title: The shift in the distribution of polysome-classes in the course of the maturation process of reticulocytes
Abstract: Polyribosome profiles from reticulocytes under conditions of maximal conservation of polysomes were obtained by sucrose-gradient analysis using media containing a high K+ concentration, heparin and cycloheximide. Young reticulocytes and reticulocytes in the phase of transition to erythrocytes were obtained from rabbits during a reticulocyte crisis after phlebotomy or phenylhydrazine treatment. It is shown that one of the aspects of the maturation process of the reticulocytes is a shift in the distribution of polysomes from the heavy polysomes to the lighter ones. The percentage of ribosomes bound to mRNA is fairly constant, whereas the total amount of ribosomes per cell decreases sharply with maturation.
Publication Year: 1974
Publication Date: 1974-09-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 6
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