Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1968114963', 'doi': 'https://doi.org/10.1074/jbc.m112.378695', 'title': 'Inhibition of Transmitter Release and Attenuation of Anti-retroviral-associated and Tibial Nerve Injury-related Painful Peripheral Neuropathy by Novel Synthetic Ca2+ Channel Peptides', 'display_name': 'Inhibition of Transmitter Release and Attenuation of Anti-retroviral-associated and Tibial Nerve Injury-related Painful Peripheral Neuropathy by Novel Synthetic Ca2+ Channel Peptides', 'publication_year': 2012, 'publication_date': '2012-10-01', 'ids': {'openalex': 'https://openalex.org/W1968114963', 'doi': 'https://doi.org/10.1074/jbc.m112.378695', 'mag': '1968114963', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22891239', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3471755'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m112.378695', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1074/jbc.m112.378695', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5000781338', 'display_name': 'Sarah M. Wilson', 'orcid': 'https://orcid.org/0000-0002-5579-6996'}, 'institutions': [{'id': 'https://openalex.org/I55769427', 'display_name': 'Indiana University – Purdue University Indianapolis', 'ror': 'https://ror.org/05gxnyn08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55769427', 'https://openalex.org/I592451']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sarah M. Wilson', 'raw_affiliation_strings': ['Department of Program in Medical Neurosciences, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202'], 'affiliations': [{'raw_affiliation_string': 'Department of Program in Medical Neurosciences, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202', 'institution_ids': ['https://openalex.org/I55769427']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087000290', 'display_name': 'Brian S. Schmutzler', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I55769427', 'display_name': 'Indiana University – Purdue University Indianapolis', 'ror': 'https://ror.org/05gxnyn08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55769427', 'https://openalex.org/I592451']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Brian S. Schmutzler', 'raw_affiliation_strings': ['Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202', 'institution_ids': ['https://openalex.org/I55769427']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030330408', 'display_name': 'Joel M. Brittain', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I55769427', 'display_name': 'Indiana University – Purdue University Indianapolis', 'ror': 'https://ror.org/05gxnyn08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55769427', 'https://openalex.org/I592451']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joel M. Brittain', 'raw_affiliation_strings': ['Department of Program in Medical Neurosciences, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202'], 'affiliations': [{'raw_affiliation_string': 'Department of Program in Medical Neurosciences, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202', 'institution_ids': ['https://openalex.org/I55769427']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031982405', 'display_name': 'Erik T. Dustrude', 'orcid': 'https://orcid.org/0000-0002-1753-8603'}, 'institutions': [{'id': 'https://openalex.org/I55769427', 'display_name': 'Indiana University – Purdue University Indianapolis', 'ror': 'https://ror.org/05gxnyn08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55769427', 'https://openalex.org/I592451']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Erik T. Dustrude', 'raw_affiliation_strings': ['Department of Program in Medical Neurosciences, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202'], 'affiliations': [{'raw_affiliation_string': 'Department of Program in Medical Neurosciences, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202', 'institution_ids': ['https://openalex.org/I55769427']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036387210', 'display_name': 'Matthew S. Ripsch', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I55769427', 'display_name': 'Indiana University – Purdue University Indianapolis', 'ror': 'https://ror.org/05gxnyn08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55769427', 'https://openalex.org/I592451']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Matthew S. Ripsch', 'raw_affiliation_strings': ['Department of Anesthesia, Indiana University School of Medicine, Indianapolis, Indiana 46202'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesia, Indiana University School of Medicine, Indianapolis, Indiana 46202', 'institution_ids': ['https://openalex.org/I55769427']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089003738', 'display_name': 'Jessica J. Pellman', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I55769427', 'display_name': 'Indiana University – Purdue University Indianapolis', 'ror': 'https://ror.org/05gxnyn08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55769427', 'https://openalex.org/I592451']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jessica J. Pellman', 'raw_affiliation_strings': ['Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202', 'institution_ids': ['https://openalex.org/I55769427']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010472961', 'display_name': 'Tae-Sung Yeum', 'orcid': 'https://orcid.org/0000-0002-9623-5861'}, 'institutions': [{'id': 'https://openalex.org/I55769427', 'display_name': 'Indiana University – Purdue University Indianapolis', 'ror': 'https://ror.org/05gxnyn08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55769427', 'https://openalex.org/I592451']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Tae-Sung Yeum', 'raw_affiliation_strings': ['Department of Anesthesia, Indiana University School of Medicine, Indianapolis, Indiana 46202'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesia, Indiana University School of Medicine, Indianapolis, Indiana 46202', 'institution_ids': ['https://openalex.org/I55769427']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076467181', 'display_name': 'Joyce Harts Hurley', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I55769427', 'display_name': 'Indiana University – Purdue University Indianapolis', 'ror': 'https://ror.org/05gxnyn08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55769427', 'https://openalex.org/I592451']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joyce H. Hurley', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202', 'Department of Program in Medical Neurosciences, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202', 'institution_ids': ['https://openalex.org/I55769427']}, {'raw_affiliation_string': 'Department of Program in Medical Neurosciences, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202', 'institution_ids': ['https://openalex.org/I55769427']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044636608', 'display_name': 'Cynthia M. Hingtgen', 'orcid': 'https://orcid.org/0009-0008-9064-4307'}, 'institutions': [{'id': 'https://openalex.org/I55769427', 'display_name': 'Indiana University – Purdue University Indianapolis', 'ror': 'https://ror.org/05gxnyn08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55769427', 'https://openalex.org/I592451']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Cynthia M. Hingtgen', 'raw_affiliation_strings': ['Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202', 'Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202', 'Department of Program in Medical Neurosciences, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202'], 'affiliations': [{'raw_affiliation_string': 'Department of Program in Medical Neurosciences, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202', 'institution_ids': ['https://openalex.org/I55769427']}, {'raw_affiliation_string': 'Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202', 'institution_ids': ['https://openalex.org/I55769427']}, {'raw_affiliation_string': 'Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana 46202', 'institution_ids': ['https://openalex.org/I55769427']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076222076', 'display_name': 'Fletcher A. White', 'orcid': 'https://orcid.org/0000-0002-8408-9262'}, 'institutions': [{'id': 'https://openalex.org/I55769427', 'display_name': 'Indiana University – Purdue University Indianapolis', 'ror': 'https://ror.org/05gxnyn08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55769427', 'https://openalex.org/I592451']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Fletcher A. White', 'raw_affiliation_strings': ['Department of Anesthesia, Indiana University School of Medicine, Indianapolis, Indiana 46202', 'Department of Program in Medical Neurosciences, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202'], 'affiliations': [{'raw_affiliation_string': 'Department of Program in Medical Neurosciences, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202', 'institution_ids': ['https://openalex.org/I55769427']}, {'raw_affiliation_string': 'Department of Anesthesia, Indiana University School of Medicine, Indianapolis, Indiana 46202', 'institution_ids': ['https://openalex.org/I55769427']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5012031138', 'display_name': 'Rajesh Khanna', 'orcid': 'https://orcid.org/0000-0002-9066-2969'}, 'institutions': [{'id': 'https://openalex.org/I55769427', 'display_name': 'Indiana University – Purdue University Indianapolis', 'ror': 'https://ror.org/05gxnyn08', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55769427', 'https://openalex.org/I592451']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Rajesh Khanna', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202', 'Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202', 'Department of Program in Medical Neurosciences, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202', 'Sophia Therapeutics LLC, Indianapolis, Indiana 46202'], 'affiliations': [{'raw_affiliation_string': 'Department of Program in Medical Neurosciences, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202', 'institution_ids': ['https://openalex.org/I55769427']}, {'raw_affiliation_string': 'Sophia Therapeutics LLC, Indianapolis, Indiana 46202', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana 46202', 'institution_ids': ['https://openalex.org/I55769427']}, {'raw_affiliation_string': 'Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202', 'institution_ids': ['https://openalex.org/I55769427']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5012031138'], 'corresponding_institution_ids': ['https://openalex.org/I55769427'], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 3.9, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 45, 'citation_normalized_percentile': {'value': 0.873516, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '287', 'issue': '42', 'first_page': '35065', 'last_page': '35077'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10196', 'display_name': 'Mechanisms and Management of Neuropathic Pain', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10196', 'display_name': 'Mechanisms and Management of Neuropathic Pain', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11274', 'display_name': 'Botulinum Toxin in Neurology and Medicine', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12477', 'display_name': 'Immunotoxin Therapy for Cancer Treatment', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/microscale-thermophoresis', 'display_name': 'Microscale thermophoresis', 'score': 0.5619326}, {'id': 'https://openalex.org/keywords/pain-modulation', 'display_name': 'Pain Modulation', 'score': 0.53016}], 'concepts': [{'id': 'https://openalex.org/C25824698', 'wikidata': 'https://www.wikidata.org/wiki/Q6840012', 'display_name': 'Microscale thermophoresis', 'level': 2, 'score': 0.5619326}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5519087}, {'id': 'https://openalex.org/C2779281246', 'wikidata': 'https://www.wikidata.org/wiki/Q172847', 'display_name': 'Peptide', 'level': 2, 'score': 0.53956044}, {'id': 'https://openalex.org/C2777107010', 'wikidata': 'https://www.wikidata.org/wiki/Q2798704', 'display_name': 'Neuropathic pain', 'level': 2, 'score': 0.46785027}, {'id': 'https://openalex.org/C15490471', 'wikidata': 'https://www.wikidata.org/wiki/Q2734305', 'display_name': 'Nociception', 'level': 3, 'score': 0.43463448}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.40181297}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.35493645}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.34621507}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.32043493}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.31189704}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.23812085}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.1604155}], 'mesh': [{'descriptor_ui': 'D016263', 'descriptor_name': 'AIDS-Associated Nephropathy', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D020864', 'descriptor_name': 'Calcium Channels, N-Type', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D005727', 'descriptor_name': 'Ganglia, Spinal', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D018377', 'descriptor_name': 'Neurotransmitter Agents', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D020429', 'descriptor_name': 'Tibial Neuropathy', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D016263', 'descriptor_name': 'AIDS-Associated Nephropathy', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D016263', 'descriptor_name': 'AIDS-Associated Nephropathy', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016263', 'descriptor_name': 'AIDS-Associated Nephropathy', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016263', 'descriptor_name': 'AIDS-Associated Nephropathy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015740', 'descriptor_name': 'Calcitonin Gene-Related Peptide', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015740', 'descriptor_name': 'Calcitonin Gene-Related Peptide', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015740', 'descriptor_name': 'Calcitonin Gene-Related Peptide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020864', 'descriptor_name': 'Calcium Channels, N-Type', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020864', 'descriptor_name': 'Calcium Channels, N-Type', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020864', 'descriptor_name': 'Calcium Channels, N-Type', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005727', 'descriptor_name': 'Ganglia, Spinal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005727', 'descriptor_name': 'Ganglia, Spinal', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008817', 'descriptor_name': 'Mice, Mutant Strains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009456', 'descriptor_name': 'Neurofibromatosis 1', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D009456', 'descriptor_name': 'Neurofibromatosis 1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009456', 'descriptor_name': 'Neurofibromatosis 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009456', 'descriptor_name': 'Neurofibromatosis 1', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009456', 'descriptor_name': 'Neurofibromatosis 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D025542', 'descriptor_name': 'Neurofibromin 1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D025542', 'descriptor_name': 'Neurofibromin 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D025542', 'descriptor_name': 'Neurofibromin 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009474', 'descriptor_name': 'Neurons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018377', 'descriptor_name': 'Neurotransmitter Agents', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018377', 'descriptor_name': 'Neurotransmitter Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059225', 'descriptor_name': 'Nociception', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D059225', 'descriptor_name': 'Nociception', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011993', 'descriptor_name': 'Recombinant Fusion Proteins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D020429', 'descriptor_name': 'Tibial Neuropathy', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D020429', 'descriptor_name': 'Tibial Neuropathy', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020429', 'descriptor_name': 'Tibial Neuropathy', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D020429', 'descriptor_name': 'Tibial Neuropathy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054322', 'descriptor_name': 'tat Gene Products, Human Immunodeficiency Virus', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D054322', 'descriptor_name': 'tat Gene Products, Human Immunodeficiency Virus', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D054322', 'descriptor_name': 'tat Gene Products, Human Immunodeficiency Virus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m112.378695', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3471755', 'pdf_url': 'https://europepmc.org/articles/pmc3471755?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471755', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22891239', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m112.378695', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.72, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 63, 'referenced_works': ['https://openalex.org/W16266328', 'https://openalex.org/W1924075688', 'https://openalex.org/W1965547314', 'https://openalex.org/W1968770896', 'https://openalex.org/W1969635978', 'https://openalex.org/W1972286844', 'https://openalex.org/W1974988379', 'https://openalex.org/W1984596133', 'https://openalex.org/W1989768699', 'https://openalex.org/W1993971194', 'https://openalex.org/W1998801332', 'https://openalex.org/W1999893599', 'https://openalex.org/W2003931218', 'https://openalex.org/W2004507647', 'https://openalex.org/W2004909214', 'https://openalex.org/W2005040986', 'https://openalex.org/W2008075340', 'https://openalex.org/W2014107572', 'https://openalex.org/W2015651475', 'https://openalex.org/W2017444651', 'https://openalex.org/W2017732628', 'https://openalex.org/W2017810117', 'https://openalex.org/W2019155451', 'https://openalex.org/W2019365444', 'https://openalex.org/W2024124332', 'https://openalex.org/W2028262137', 'https://openalex.org/W2029815031', 'https://openalex.org/W2033782734', 'https://openalex.org/W2037872375', 'https://openalex.org/W2038531512', 'https://openalex.org/W2041266960', 'https://openalex.org/W2046786652', 'https://openalex.org/W2052359142', 'https://openalex.org/W2053495851', 'https://openalex.org/W2055098706', 'https://openalex.org/W2059250038', 'https://openalex.org/W2068205523', 'https://openalex.org/W2069268149', 'https://openalex.org/W2075046805', 'https://openalex.org/W2075766783', 'https://openalex.org/W2080456882', 'https://openalex.org/W2080940623', 'https://openalex.org/W2081606146', 'https://openalex.org/W2083653487', 'https://openalex.org/W2104450799', 'https://openalex.org/W2111602046', 'https://openalex.org/W2113123068', 'https://openalex.org/W2114454477', 'https://openalex.org/W2117920329', 'https://openalex.org/W2117954460', 'https://openalex.org/W2132807488', 'https://openalex.org/W2135923112', 'https://openalex.org/W2137634045', 'https://openalex.org/W2144724079', 'https://openalex.org/W2144810687', 'https://openalex.org/W2146103350', 'https://openalex.org/W2150190558', 'https://openalex.org/W2155452679', 'https://openalex.org/W2159998111', 'https://openalex.org/W2258943706', 'https://openalex.org/W2395207752', 'https://openalex.org/W2417258733', 'https://openalex.org/W70790455'], 'related_works': ['https://openalex.org/W4286855953', 'https://openalex.org/W4286002068', 'https://openalex.org/W3155833996', 'https://openalex.org/W2897926088', 'https://openalex.org/W2607506311', 'https://openalex.org/W2567890153', 'https://openalex.org/W2220573054', 'https://openalex.org/W2146103350', 'https://openalex.org/W2139004599', 'https://openalex.org/W2133693793'], 'abstract_inverted_index': {'N-type': [0], 'Ca2+': [1, 142], 'channels': [2], '(CaV2.2)': [3], 'are': [4], 'a': [5, 159, 169, 297, 314], 'nidus': [6], 'for': [7], 'neurotransmitter': [8], 'release': [9, 276], 'and': [10, 126, 133, 164, 184, 198, 205, 208, 224, 228, 251, 321, 346], 'nociceptive': [11], 'transmission.': [12], 'However,': [13], 'the': [14, 31, 37, 140, 151, 178, 185, 235, 240, 278, 337], 'use': [15], 'of': [16, 30, 34, 131, 239, 277, 300, 318, 343], 'CaV2.2': [17, 35, 166, 219], 'blockers': [18], 'in': [19, 248, 249, 252, 258, 284, 292, 313], 'pain': [20, 135], 'therapeutics': [21], 'is': [22], 'limited': [23], 'by': [24, 136, 222, 232, 266, 333], 'side': [25], 'effects': [26], 'resulting': [27], 'from': [28, 139, 150, 294], 'inhibition': [29], 'physiological': [32], 'functions': [33], 'within': [36, 177], 'CNS.': [38], 'We': [39], 'identified': [40, 174], 'an': [41], 'anti-nociceptive': [42], 'peptide': [43, 170, 273, 283], '(Brittain,': [44], 'J.': [45, 70, 108], 'M.,': [46, 52, 76, 85, 93, 101, 116], 'Duarte,': [47], 'D.': [48], 'B.,': [49], 'Wilson,': [50], 'S.': [51, 73, 97], 'Zhu,': [53], 'W.,': [54, 63], 'Ballard,': [55], 'C.,': [56, 71], 'Johnson,': [57], 'P.': [58], 'L.,': [59], 'Liu,': [60], 'N.,': [61, 103], 'Xiong,': [62], 'Ripsch,': [64], 'M.': [65, 87, 121], 'S.,': [66, 82, 119], 'Wang,': [67], 'Y.,': [68], 'Fehrenbacher,': [69], 'Fitz,': [72], 'D.,': [74], 'Khanna,': [75, 127], 'Park,': [77], 'C.': [78, 100], 'K.,': [79], 'Schmutzler,': [80], 'B.': [81, 84], 'Cheon,': [83], 'Due,': [86], 'R.,': [88, 106, 122], 'Brustovetsky,': [89, 102], 'T.,': [90], 'Ashpole,': [91], 'N.': [92], 'Hudmon,': [94], 'A.,': [95, 113, 125], 'Meroueh,': [96], 'O.,': [98], 'Hingtgen,': [99], 'Ji,': [104], 'R.': [105, 128], 'Hurley,': [107], 'H.,': [109], 'Jin,': [110], 'X.,': [111], 'Shekhar,': [112], 'Xu,': [114], 'X.': [115], 'Oxford,': [117], 'G.': [118], 'Vasko,': [120], 'White,': [123], 'F.': [124], '(2011)': [129], 'Suppression': [130], 'inflammatory': [132], 'neuropathic': [134], 'uncoupling': [137], 'CRMP2': [138, 204, 216], 'presynaptic': [141], 'channel': [143], 'complex.': [144], 'Nat.': [145], 'Med.': [146], '17,': [147], '822–829)': [148], 'derived': [149], 'axonal': [152], 'collapsin': [153], 'response': [154], 'mediator': [155], 'protein': [156, 160, 236], '2': [157], '(CRMP2),': [158], 'known': [161], 'to': [162, 303, 341], 'bind': [163], 'enhance': [165], 'activity.': [167], 'Using': [168], 'tiling': [171], 'array,': [172], 'we': [173], 'novel': [175], 'peptides': [176], 'first': [179], 'intracellular': [180], 'loop': [181], '(CaV2.2(388–402),': [182], '"L1")': [183], 'distal': [186], 'C': [187], 'terminus': [188], '(CaV1.2(2014–2028)': [189], '"Ct-dis")': [190], 'that': [191, 215, 330], 'bound': [192], 'CRMP2.': [193], 'Microscale': [194], 'thermophoresis': [195], 'demonstrated': [196], 'micromolar': [197], 'nanomolar': [199], 'binding': [200], 'affinities': [201], 'between': [202], 'recombinant': [203], 'synthetic': [206], 'L1': [207, 223, 227], 'Ct-dis': [209, 225, 307], 'peptides,': [210, 332], 'respectively.': [211], 'Co-immunoprecipitation': [212], 'experiments': [213], 'showed': [214], 'association': [217], 'with': [218, 234, 296, 336], 'was': [220, 264], 'inhibited': [221, 265, 274], 'peptides.': [226, 268], 'Ct-dis,': [229, 269], 'rendered': [230], 'cell-penetrant': [231], 'fusion': [233], 'transduction': [237], 'domain': [238], 'human': [241], 'immunodeficiency': [242], 'virus': [243], 'TAT': [244], 'protein,': [245], 'were': [246, 290], 'tested': [247], 'vitro': [250], 'vivo': [253], 'experiments.': [254], 'Depolarization-induced': [255], 'calcium': [256], 'influx': [257], 'dorsal': [259], 'root': [260], 'ganglion': [261], '(DRG)': [262], 'neurons': [263], 'both': [267], 'but': [270], 'not': [271], 'L1,': [272], 'depolarization-stimulated': [275], 'neuropeptide': [279], 'transmitter': [280], 'calcitonin': [281], 'gene-related': [282], 'mouse': [285], 'DRG': [286], 'neurons.': [287], 'Similar': [288], 'results': [289], 'obtained': [291], 'DRGs': [293], 'mice': [295], 'heterozygous': [298], 'mutation': [299], 'Nf1': [301], 'linked': [302], 'neurofibromatosis': [304], 'type': [305], '1.': [306], 'peptide,': [308], 'administered': [309], 'intraperitoneally,': [310], 'exhibited': [311], 'antinociception': [312], 'zalcitabine': [315], '(2′-3′-dideoxycytidine)': [316], 'model': [317], 'AIDS': [319], 'therapy-induced': [320], 'tibial': [322], 'nerve': [323], 'injury-related': [324], 'peripheral': [325], 'neuropathy.': [326], 'This': [327], 'study': [328], 'suggests': [329], 'CaV': [331], 'perturbing': [334], 'interactions': [335], 'neuromodulator': [338], 'CRMP2,': [339], 'contribute': [340], 'suppression': [342], 'neuronal': [344], 'hypersensitivity': [345], 'nociception.': [347]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1968114963', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 4}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 8}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-09-16T17:27:03.937190', 'created_date': '2016-06-24'}