Publication Information

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'article.': [88], 'Previous': [89, 94], 'versions:': [90], 'January': [91], '1,': [92], '2010:': [93], 'Version': [95], '1': [96, 3174, 3183], 'After': [97, 822, 1413, 2100, 2944], 'at': [98, 127, 238, 908, 1324, 1664, 2455, 2797], 'least': [99, 2798], '2': [100, 2280, 3475], 'decades': [101, 2088, 2945], 'growing': [103], 'awareness': [104], 'on': [105, 982, 1628, 1783, 2344, 2465, 2678, 2948, 3503, 3854, 4116], 'coronary': [106, 375, 386, 401, 428, 448, 473, 491, 514, 527, 632, 688, 712, 718, 756, 831, 923, 933, 952, 1028, 1033, 1048, 1091, 1184, 1260, 1286, 1429, 1740, 1769, 1881, 2152, 2431, 2577, 2686, 2754, 2841, 2871, 2892, 3122, 3239, 3269, 3318, 3339, 3382, 3399, 3581, 3634, 3676, 3702, 3712, 3740, 3815, 3943, 4008, 4063], 'heart': [107, 136, 157, 170, 191, 255, 275, 312, 376, 551, 1108, 1273, 1320, 1356, 1401, 1814, 1882, 2153, 2823, 2842, 2872, 3075, 3123, 3240, 3510, 3600, 3709], 'disease': [108, 137, 158, 171, 192, 256, 276, 313, 377, 403, 449, 552, 1265, 1274, 1321, 1402, 1741, 1770, 1883, 2042, 2154, 2687, 2824, 2843, 2915, 3076, 3124], 'women,': [110, 194, 331, 416, 431, 765, 1746, 2047, 2728], 'we': [111, 213, 1359, 1377, 1895, 2359, 2808, 2856, 3094], 'left': [113, 2810], 'with': [114, 356, 425, 452, 651, 842, 918, 927, 1036, 1097, 1104, 1129, 1172, 1201, 1203, 1219, 1367, 1433, 1473, 1482, 1493, 1504, 1536, 1726, 1795, 1798, 1848, 1880, 1910, 1913, 1963, 2126, 2151, 2163, 2187, 2227, 2398, 2486, 2489, 2511, 2601, 2643, 2693, 2745, 2811, 3073, 3238, 3397, 3508, 3570, 3674, 4003, 4055], 'many': [115, 222, 986, 1439, 1541, 2094, 2727], 'questions,': [116, 3109], 'few': [117, 729, 2832], 'answers,': [118], 'plenty': [120], 'opinions.': [122], 'Review': [123], 'articles,': [124], 'books,': [125], 'sessions': [126], 'scientific': [128, 201], 'meetings,': [129], 'commentaries': [131], 'regarding': [132], 'various': [133], 'aspects': [134], 'women': [139, 278, 289, 315, 354, 371, 410, 554, 566, 622, 667, 698, 751, 788, 827, 841, 871, 888, 916, 1019, 1078, 1103, 1128, 1170, 1190, 1218, 1316, 1340, 1404, 1426, 1507, 1558, 1597, 1663, 1704, 1772, 1794, 1879, 1909, 1926, 1957, 1975, 2002, 2068, 2081, 2124, 2150, 2226, 2275, 2293, 2413, 2472, 2485, 2508, 2554, 2632, 2645, 2667, 2723, 2744, 2826, 2879, 2900, 2917, 3023, 3041, 3070, 3099, 3192, 3507, 4002, 4054], 'have': [140, 144, 160, 184, 372, 496, 627, 732, 746, 785, 829, 847, 889, 921, 1179, 1318, 1800, 1863, 1898, 1987, 2020, 2231, 2240, 2389, 2612, 2830, 2901, 3043], 'proliferated.': [141], 'These': [142, 516, 2009, 2403, 2648, 3035], 'reports': [143, 989], 'highlighted': [145], 'important': [146, 229, 324, 960, 1948], 'sex': [147, 629, 659, 864, 1348, 1448, 1485, 1526, 1589, 1655, 1682, 1777, 1825, 1941, 2171, 2254, 2337, 2375, 2416, 2619, 2679, 2706, 2838, 2862, 3051, 3853], 'differences': [148, 178, 249, 259, 333, 630, 865, 943, 1349, 1449, 1486, 1527, 1552, 1656, 1683, 1778, 1826, 1844, 1942, 2250, 2267, 2302, 2335, 2376, 2392, 2422, 2445, 2506, 2528, 2609, 2620, 2663, 2680, 2707, 2791, 2839, 2863, 3052, 3060, 3233, 3264, 3313, 3334, 3375, 3463, 3564, 3665, 3738, 4168, 4197, 4234, 4275], 'pathophysiology,': [151], 'presentation,': [152, 2867, 3566], 'treatment': [154, 168, 273, 341, 2148, 2252, 2308, 2334, 2421, 3120], 'ischemic': [156, 254, 311, 550, 1272, 1319, 1355, 1400, 2822, 3509, 3599], 'denounced': [161, 1988], 'pervasive': [162], 'sex-related': [163], 'disparities': [164], 'referral': [166, 2793, 3062, 3086], 'for': [169, 176, 270, 337, 347, 391, 447, 549, 584, 687, 725, 755, 815, 824, 1025, 1032, 1064, 1082, 1232, 1326, 1399, 1438, 1498, 1516, 1557, 1739, 1840, 1870, 1902, 1958, 2161, 2283, 2354, 2393, 2425, 2437, 2504, 2726, 2733, 2753, 2764, 2837, 3031, 3064, 3128, 3210, 3344, 4158], 'as': [172, 544, 579, 669, 671, 897, 1371, 1538, 1810, 2170, 2305, 2430, 2659, 2970, 2981, 3008, 3945], 'a': [173, 486, 545, 556, 580, 592, 646, 681, 929, 1010, 1015, 1043, 1167, 1196, 1256, 1393, 1555, 1629, 1639, 1801, 1873, 1887, 1899, 1921, 1964, 2004, 2014, 2077, 2116, 2164, 2217, 2523, 2531, 2543, 2546, 2596, 2799, 2854, 3019, 3345, 3401, 3946], 'major': [174, 546, 1257], 'reason': [175], 'outcome': [177, 1353, 1529, 1686, 1843, 2869, 3569, 4239, 4281], 'between': [179, 2274, 2507, 2553, 2666, 2916, 3069], 'sexes.': [181], 'Such': [182], 'activities': [183], 'been': [185, 497, 576, 1303, 1436, 1865, 2159, 2182, 3045], 'useful': [186], 'driving': [188], 'attention': [189], 'an': [195, 323, 1210, 1989, 1995, 2341, 2904, 3105], 'area': [196, 818], 'largely': [197, 770], 'ignored': [198], 'by': [199, 360, 772, 942, 992, 1062, 1540, 1588, 1608, 1625, 1752, 1758, 2027, 2040, 2199, 2253, 2336, 3141, 3706, 3744], 'community': [202, 885], 'public': [205], 'just': [206], '15': [207], '20': [209], 'years': [210, 1708], 'ago.': [211], 'However,': [212], 'must': [214, 1748, 2360], 'recognize': [215], 'that': [216, 342, 499, 603, 731, 787, 840, 861, 887, 951, 1150, 1166, 1215, 1292, 1300, 1388, 1447, 1654, 1703, 1832, 1935, 2019, 2067, 2193, 2207, 2363, 2464, 2478, 2497, 2561, 2585, 2608, 2651, 2673, 2743, 2910, 2925], 'date,': [218], 'limited': [219, 991], 'data': [220, 968, 1249, 1572, 2677, 2739, 2773, 2784, 4205], 'substantiate': [221], 'these': [224, 484, 833, 988, 1189, 1293, 1312, 1334, 1389, 1480, 1591, 1604, 1618, 1819, 2438, 2469, 2957, 3108], 'statements;': [225], 'such': [226, 332, 1370, 1809, 2208, 2300, 2429, 2790, 2938, 2969, 3007], 'recognition': [227], 'is': [228, 306, 322, 358, 405, 541, 591, 598, 938, 957, 1280, 1290, 1298, 1446, 1468, 1568, 1593, 1635, 1652, 1678, 1830, 1918, 1961, 1980, 2191, 2442, 2473, 2496, 2522, 2703, 2846, 2888, 3139], 'guide': [231], 'future': [232], 'research': [233, 1301, 2355], 'efforts.': [234], 'A': [235, 1186, 1867, 2695], 'careful': [236], 'look': [237], 'recently': [239], 'published': [240], 'literature': [241, 2180], 'reveals': [242], 'only': [243, 1461, 2279], 'modest': [244], 'advancements': [245], 'toward': [246], 'clarifying': [247], 'sex-based': [248, 258], 'pathophysiology': [252, 328, 350, 1616, 2820, 3574], 'outcome.': [261], 'At': [262], 'same': [264], 'time,': [265], 'key': [266], 'questions': [267, 2813, 2817, 2875], 'concerning': [268], 'strategies': [269, 336], 'prevention': [271, 3117], 'remain': [279, 2827, 2876], 'unanswered,': [280], 'cardiovascular': [282, 1959, 1968, 1998, 2028, 2041, 2112, 2351, 2735, 2806, 2883, 3054, 3101, 3200, 3378, 3950], 'clinical': [283, 838, 867, 1576, 2147, 2196, 2683, 2765, 3102], 'trials': [284, 3203], 'continue': [285], 'include': [287, 517], 'fewer': [288], 'than': [290, 378, 411, 465, 623, 705, 715, 793, 851, 876, 894, 1050, 1341, 1405, 1512, 1601, 1645, 1667, 1706, 1722, 1927, 1949, 2071, 2222, 2415, 2542, 2654, 2814, 2978, 3024], 'men.1Is': [291], 'Pathophysiology': [293], 'Ischemic': [295], 'Different': [298], 'Than': [301, 1411, 2135], 'Men?A': [303], 'fundamental': [304], 'question': [305, 325], 'whether': [307, 2444, 2789], 'mechanisms': [309, 1335, 2913], 'underlying': [310, 1617, 2961], 'differ': [316, 352], 'from': [317, 884, 901, 1380, 1574, 2013, 2340, 2409, 2582, 2689, 2740, 2774, 2882, 3145, 3440, 3552, 3955, 4066, 4206], 'those': [318, 433, 1035, 1051, 1202], 'men.': [320, 624, 1849], 'This': [321, 947, 1562, 1932, 2056], 'because': [326, 2073], 'if': [327, 1333, 1363, 2118, 2513, 3082], 'differs': [329], 'can': [334, 3085, 3093, 3111], 'inform': [335], 'prevention,': [338], 'detection,': [339], 'would': [343, 441, 1345, 1701], 'be': [344, 444, 693, 1444, 1612, 1718, 1749, 1855, 1946, 2205, 2214, 2361, 2493, 2657, 2671, 2751, 2954, 2996, 3088, 3112], 'effective': [346], 'women.': [348, 1276, 2929, 3350, 3638], 'That': [349, 1763, 2579], 'may': [351, 1178, 1611, 1854, 1945, 2011, 2213, 2338, 2368, 2405, 2491], 'compared': [355, 451, 733, 917, 1095, 1200, 1432, 1725, 1797, 1912, 2125, 2488], 'men': [357, 379, 466, 672, 716, 753, 895, 920, 1434, 1513, 1602, 1668, 1727, 1799, 1928, 2083, 2157, 2277, 2288, 2490, 2510, 2919, 3026, 3072], 'suggested': [359, 2778], 'several': [361, 2087], 'factors.': [362, 946], 'First,': [363], 'despite': [364, 470, 804, 2003, 2713], 'having': [365], 'more': [366, 407, 478, 613, 808, 1337, 1719, 1947, 2812, 2999, 3038], 'symptoms': [367, 419], 'physical': [369], 'limitations,2,3': [370], 'less': [373, 471, 710, 790, 1278, 1569, 1723, 2145, 2241, 2426, 2541, 2628, 2748], 'obstructive': [374, 400, 610, 696, 1220, 2243, 2453, 4062], 'along': [380], 'entire': [382, 1972], 'spectrum': [383], 'acute': [385, 461, 1372, 1428, 1622, 2905, 3317, 4120, 4176, 4241, 4283], 'syndromes4': [387], 'when': [389, 955, 2899, 3090], 'referred': [390, 686, 754, 1024, 2752], 'revascularization.5,6': [392], 'Second,': [393], 'syndrome': [395], 'chest': [397, 417, 560, 1083, 1130, 1163, 1173, 4004], 'pain': [398, 418, 1084, 1131, 1174, 4005], 'without': [399, 1162], 'artery': [402, 719, 1092, 3270, 3340, 3713, 3741], '(CAD)': [404], 'distinctly': [406], 'common': [408, 2718], 'men.7': [413], 'Third,': [414], 'among': [415, 621, 1315, 1403, 1406, 1490, 1502, 1857, 1925, 1955, 2001, 2412, 2630, 2956], 'disability': [421, 564], 'do': [422, 1307, 1330, 1360, 1454, 1509, 1560, 1821, 1896], 'not': [423, 700, 949, 958, 1252, 1291, 1308, 1331, 1361, 1455, 1672, 1697, 1822, 1897, 2119, 2369, 2474, 2492, 2500], 'correlate': [424], 'severity': [426], 'stenoses.8': [429], 'Fourth,': [430], 'particularly': [432], 'who': [434, 1079, 1086, 1317], 'young': [436, 1692], 'or': [437, 677, 844, 1239, 1322, 1374, 1385, 1396, 1553, 1631, 1756, 1760, 1937, 1993, 2903], 'middle-aged': [438, 1694], '(whom': [439], 'one': [440, 759, 2562], 'expect': [442, 1702], 'advantaged': [446, 1720, 1724], 'risk': [450, 586, 809, 912, 945, 1325, 1499, 1519, 1666, 1754, 1781, 1805, 1836, 1906, 1917, 3005, 3030, 3816, 3892], 'men),': [453], 'show': [454, 701, 2076], 'higher': [455, 922, 1044, 1197, 1225, 1420, 1599, 1802, 3346], 'rates': [456, 1424, 2000, 2075, 3063, 3087], 'adverse': [458, 507, 1368, 3032], 'outcomes': [459, 508, 1944, 3379], 'after': [460, 723, 813, 1119, 1427, 1452, 1496, 1514, 1669, 1673, 2664, 2762, 3268, 3338, 3380, 3467, 4175, 4200], 'myocardial': [462, 3431, 3468, 3895, 3995, 4056, 4114, 4121, 4177, 4201, 4242, 4284], 'infarction': [463, 4115, 4202, 4243], '(MI)': [464], 'similar': [468, 748, 1213, 1729, 1981, 2078, 2117, 2779], 'age,': [469, 1710], 'severe': [472, 2242], 'narrowing,': [474], 'smaller': [475, 778, 830], 'infarcts,': [476], 'preserved': [479], 'systolic': [480], 'function.9': [481], 'To': [482], 'explain': [483, 863, 1347, 1824, 2861], 'observations,': [485], 'number': [487, 1001, 2023, 2032, 2110], 'abnormalities': [489, 605, 860, 1391], 'vascular': [492, 604, 643, 859, 953, 2851, 2923, 2963, 2971], 'structure': [493, 633], 'function': [495, 635, 704, 875, 893, 3671, 3862], 'proposed': [498], 'could': [500, 1773], 'lead': [501], 'symptoms,': [503], 'disability,': [504], 'other': [506, 640, 858, 1646, 1674, 1737, 1851, 2095, 2221, 2315, 2653, 2950, 2977], 'absence': [511, 608, 1990, 4060], 'critical': [513], 'stenosis.10–12': [515], 'positive': [518, 676], 'remodeling': [519], '(compensatory': [520], 'vessel': [521, 820, 1287, 1658], 'enlargement),': [522], 'diffuse': [523], 'atherosclerosis': [524, 3576], '(versus': [525], 'plaque),': [526], 'endothelial': [528, 703, 713, 874, 892, 1261, 3670, 3861], 'dysfunction': [529, 714, 1262], 'leading': [530], 'vasoconstriction,': [532], 'microvascular': [534, 537, 744, 1183, 1264, 3580], 'disease.': [535, 1109, 1328, 1357, 2873, 3241, 3511, 3582, 3714], 'Coronary': [536, 1415, 3891], 'disease,': [538, 2884], 'particular,': [540], 'put': [542, 577, 1662], 'forward': [543], 'etiologic': [547, 1395], 'factor': [548], 'prevalent': [557, 1311, 1338, 3039], 'determinant': [558], 'pain,': [561, 1164], 'ischemia,': [562], '("microvascular': [567], 'angina").12': [568], 'Consequently,': [569], 'identification': [571], 'nonobstructive': [573], 'atheroma': [574, 611, 791, 800, 3667], 'has': [575, 978, 1302, 1435, 2043, 2114, 2158, 2181], 'forth': [578], 'potentially': [581], 'helpful': [582], 'strategy': [583], 'stratification': [587], 'women.12Although': [589], 'compelling': [593], 'theory,': [594], 'date': [596], 'there': [597, 1253, 1549, 2521, 3058], 'little': [599, 2613, 3110], 'evidence': [600, 1106, 1279, 2306, 3343], 'suggest': [602, 2650, 2742], 'commonly': [614], 'implicated': [615], 'pathogenesis': [618], 'ischemia': [620, 1180, 4057], 'Recent': [625, 2738], 'studies': [626, 730, 784, 834, 1986, 2388, 2690, 2909, 2935], 'evaluated': [628, 2997, 3046], 'using': [636], 'intravascular': [637, 782, 3745], 'ultrasound': [638, 783], 'types': [641, 1647, 1675], 'testing.': [644], 'In': [645, 680, 1014, 1053, 1477, 2257, 2530], 'sample': [647, 997, 1016], '978': [649], 'patients': [650, 685, 1472, 1481, 1492, 1503, 1535, 1695, 2186, 2397, 2600, 2692, 3673, 4246], 'established': [652, 843], 'CAD,': [653, 697], 'Nicholls': [654, 3612], 'et': [655, 2604], 'al13': [656], 'found': [657, 691, 786, 1489, 1531], 'no': [658, 1088, 1105, 1133, 1484, 1551, 2615, 2782], 'difference': [660, 768, 937, 2552, 2588], 'arterial': [662], 'remodeling;': [663], 'study,': [666, 1869, 2386], 'were': [668, 854, 1060, 1080, 1151, 1242, 2255, 2278, 2303, 2312], 'likely': [670, 2749], 'undergo': [674], 'either': [675], 'negative': [678], 'remodeling.': [679, 1288], 'study': [682, 760, 977, 1194], '142': [684], 'evaluation': [689], 'free': [694], 'did': [699], 'worse': [702], 'men.14': [706], 'actually': [708, 1508], 'had': [709, 789, 1042, 1087, 1137], 'epicardial': [711], '(shorter': [717], 'segments': [720], 'affected),': [721], 'even': [722, 812, 964, 1386, 1554, 1994, 2108, 2761], 'correction': [724, 1515], 'body': [726, 779, 816, 825], 'size.': [727], 'The': [728, 971, 1466, 1521, 2030, 2330, 4105], 'endothelium-independent': [734], 'vasodilatory': [735, 3703], 'reserve': [736, 925, 3704], 'response': [738], 'adenosine': [740], '(an': [741], 'index': [742], 'function)': [745], 'reported': [747, 1539, 2249, 2390], 'values': [749, 2367], 'angiography14,15;': [757], 'it': [761, 1297, 1651, 1747, 2169, 2190, 2202, 2441, 2498], 'was': [762, 769, 1115, 1228, 2570, 2591, 3131], 'lower': [763, 848, 2232, 2450, 2459, 2535], 'but': [766, 1085, 1460, 1671, 1696, 2781, 3042, 4006], 'explained': [771, 941, 2540], "women's": [774, 2805], 'older': [775, 805, 1547, 1698, 2631, 2644], 'age': [776, 806, 905, 1517, 1567, 1730, 3851, 4110], 'size.14': [780], 'All': [781], 'volume': [792], 'men,': [794, 852, 1343, 1914, 2051, 2072, 2635], 'including': [795, 2319, 2767], 'both': [796], 'luminal': [797], 'plaque': [798, 849, 1634, 3636], 'within': [801, 1191, 2296], 'media,': [803], 'factors,': [810, 1755], 'accounting': [814], 'surface': [817], 'size.13,14,16': [821], 'adjusting': [823, 2763], 'size,': [826], 'also': [828, 1075, 1679, 1787, 2204], 'vessels.16Although': [832], 'confirmed': [835], 'known': [837, 882, 1594, 2704], 'observation': [839], 'suspected': [845, 3074], 'CAD': [846, 2454, 2721], 'burden': [850, 3668], 'they': [853, 1364], 'unable': [855, 2859], 'identify': [857], 'might': [862], 'presentation.': [868], 'If': [869], 'anything,': [870], 'showed': [872, 1195], 'better': [873, 890, 1511, 2921], 'men;': [877, 2556], 'result': [879, 2012], 'parallels': [880], 'finding': [883], 'samples': [886], 'peripheral': [891], '(measured': [896], 'flow-mediated': [898, 3780], 'vasodilation': [899, 1038], 'percent': [900], 'baseline)': [902], 'until': [903, 2052], 'about': [904, 1282, 1595, 2705, 2818, 2834, 2848, 2877], '70': [906], 'all': [909, 1023], 'levels': [910, 2233], 'factors.17–19': [913], 'Similarly,': [914], 'asymptomatic': [915, 919, 3811, 3898], 'perfusion': [924, 2770, 3896], 'measured': [926], 'MRI,': [928], 'measure': [930], 'global': [932], 'vasoreactivity,20': [934], 'although': [935, 1818, 2400], 'part': [940, 1775, 2407, 3561], 'does': [948, 2499], 'mean': [950, 1156], 'dysfunction,': [954], 'present,': [956], 'prognostically': [959], 'women;': [962], 'however,': [963, 1057, 1223, 2440], 'respect,': [967], 'limited.': [970, 1305], "Women's": [972, 2449, 3555, 3963, 4077], 'Ischemia': [973, 3556, 3964, 4078], 'Syndrome': [974, 3557, 3965, 4079], 'Evaluation': [975, 3558, 3966, 4080], '(WISE)': [976, 3559], 'provided': [979], 'substantial': [980], 'information': [981], 'topic.': [984], 'Unfortunately,': [985], 'characteristics': [994, 1583], 'selection,': [998], 'small': [1000, 1055, 2301, 2381], '"hard"': [1003], 'end': [1004, 2942], 'points,': [1005], 'lack': [1008, 2908, 2931], 'male': [1011], 'comparison': [1012, 1847], 'group.': [1013], '163': [1018], 'enrolled': [1020], 'WISE,': [1022], 'clinically': [1026, 2372, 2494], 'indicated': [1027], 'angiography': [1029], 'assessed': [1031, 3743], 'reactivity,': [1034], 'impaired': [1037], 'intracoronary': [1040], 'acetylcholine': [1041], 'rate': [1045, 1199, 1212, 1227, 1803, 1954], 'subsequent': [1047], 'events': [1049, 1241, 1369, 3951], 'without.21': [1052], 'sample,': [1056], 'results': [1059, 2311, 2401, 3439, 3954, 4065], 'driven': [1061, 1751], 'hospitalizations': [1063, 1231], 'angina': [1065, 1233, 2700, 2746], 'percutaneous': [1067, 2538, 2576, 3381], 'interventions': [1068, 2539], '(36': [1069], '58': [1071], 'events).': [1072], 'WISE': [1073, 1193, 3443], 'investigators': [1074], 'studied': [1076], '35': [1077, 1127], 'hospitalized': [1081, 2185], 'angiographically': [1089, 1134], 'significant': [1090, 1135, 2365, 2495], 'obstructions': [1093], 'them': [1096], '12': [1098], 'age-': [1099], 'weight-matched': [1101], 'control': [1102, 1160], 'Phosphorus-31': [1110], 'nuclear': [1111, 1205, 3997], 'magnetic': [1112, 1206, 3998], 'resonance': [1113, 1207, 3999], 'spectroscopy': [1114, 1208, 4000], 'done': [1116, 3113], 'before': [1117], 'isometric': [1120], 'handgrip': [1121], 'exercise.': [1122], 'Seven': [1123], '(20%)': [1124], 'stenosis': [1136], 'decreases': [1138], 'phosphocreatine:ATP': [1141], 'ratio': [1142], '(a': [1143], 'metabolic': [1144], 'marker': [1145], 'ischemia)': [1147], 'during': [1148], 'exercise': [1149], '>2': [1152], 'SDs': [1153], 'below': [1154], 'value': [1157], 'subjects': [1161, 3812], 'suggesting': [1165, 2463], 'subgroup': [1168], 'presenting': [1171], 'normal': [1176, 1204, 3701, 4007], 'angiograms': [1177], 'due': [1181, 1229, 1565, 1579, 1613, 2215], 'disease.22': [1185], 'follow-up': [1187, 2934], 'event': [1198, 1211, 1226], 'CAD.23': [1221], 'Again,': [1222], 'repeat': [1235], 'angiography:': [1236], 'No': [1237], 'deaths': [1238, 2025, 2034, 2113], 'MI': [1240, 1373, 1475, 1495, 1609, 1688, 1796, 1911, 2228, 2533, 2665], 'documented': [1243, 1872, 2160], 'group.In': [1246], 'summary,': [1247], 'simply': [1251], 'indicate': [1255], 'role': [1258, 1284, 1398, 1641, 2616, 2991, 3021], 'etiology': [1268], 'prognosis': [1270], 'Even': [1277, 2436, 2517], 'available': [1281, 2353, 2786], 'It': [1289, 1829], 'hypotheses': [1294], 'incorrect;': [1296], 'mainly': [1299], 'too': [1304], 'We': [1306, 1329, 2829, 2907, 2930], 'know': [1309, 1332, 1362], 'how': [1310, 3084], 'conditions': [1313], 'which': [1344, 1525, 1979], 'help': [1346], 'presentation': [1351, 1784, 3236], 'Finally,': [1358, 3056], 'associated': [1366, 3237], 'death.': [1375], 'Presently,': [1376], 'far': [1379], 'being': [1381, 2715], 'able': [1382], 'conclude,': [1384], 'suggest,': [1387], 'hypothesized': [1390], 'play': [1392, 1638, 3018], 'larger': [1394, 1640, 2391, 2420, 3020], 'prognostic': [1397, 3947], 'men.Do': [1407], 'Fare': [1409], 'Worse': [1410], 'Men': [1412], 'Acute': [1414, 4210], 'Syndromes?A': [1416], 'general': [1417], 'pattern': [1418], 'mortality': [1421, 1451, 1877, 1905, 1923, 1953, 1960, 1969, 1999, 2017, 2505, 2551, 2569, 2590, 3315, 3337, 3347, 3466, 4118], 'complication': [1423], 'syndromes': [1430], '(ACS)': [1431], 'described': [1437], 'years.': [1440, 1931], 'But': [1441], 'what': [1442, 2845], 'should': [1443, 1717, 2203, 2656, 2670, 2952, 2995], 'recognized': [1445, 2206], 'ACS': [1453, 2487], 'occur': [1456, 1743, 2198], 'across': [1457], 'board': [1459], 'specific': [1463], 'patient': [1464, 1605], 'subgroups.': [1465], 'first': [1467], 'group': [1470, 1523], 'ST-segment–elevation': [1474], '(STEMI).4,24,25': [1476], 'contrast': [1478], 'STEMI,': [1483, 2399], 'usually': [1488], 'non–ST-segment–elevation': [1494], 'adjustment': [1497], 'factors': [1500, 1806, 1820, 1837, 1853, 1862, 2220, 2652, 2766, 2960, 2976, 2994, 3006, 3036, 3817, 3893], 'unstable': [1505], 'angina;': [1506], 'significantly': [1510], 'factors.4,24': [1520], 'second': [1522], 'comprises': [1532], 'younger': [1534, 1705, 1745, 1793, 1908, 3349], 'MI,': [1537, 2602], 'population-based': [1542, 2597], 'registry': [1544], 'studies.9,24,26–30': [1545], 'Among': [1546], 'patients,': [1548], 'tendency': [1556, 2165, 2331, 2524], 'better.': [1561], 'effect': [1563], 'modification': [1564], 'apparent': [1570], 'sets': [1573], 'randomized': [1575, 3201], 'trials,4,31': [1577], 'probably': [1578, 2058], 'selection': [1582], 'possible': [1585, 1653, 1831], 'differential': [1586, 2573], 'enrollment': [1587], 'trials.Little': [1592], 'why': [1596, 1681, 2878, 2885, 2895], 'face': [1598], 'risks': [1600], 'groups.': [1606], 'Differences': [1607], 'type': [1610, 4112], 'events.': [1619], 'For': [1620, 2224], 'example,': [1621, 1871, 2225, 2284], 'occlusion': [1623], 'caused': [1624, 1757, 2026, 2039], 'thrombus': [1626], 'superimposed': [1627], 'ruptured': [1630], 'eroded': [1632], 'atherosclerotic': [1633, 3635], 'believed': [1636], 'transmural': [1643], 'infarctions': [1644], 'ACS.32': [1649], 'Thus,': [1650], 'size': [1659, 2349, 3742], 'collateralization': [1661], 'greater': [1665], 'STEMI': [1670], 'ACS.It': [1677], 'unclear': [1680, 2443], 'seen': [1690, 1845, 2424], 'patients.': [1699], 'One': [1700], '50': [1707], 'majority': [1712], 'whom': [1714], 'premenopausal,': [1716], 'rather': [1721, 2414], 'terms': [1732, 3048], 'survival.': [1734], 'On': [1735], 'hand,': [1738], 'aggressive,': [1750], 'multiple': [1753], 'secondary': [1759], 'unknown': [1761, 1852], 'causes.': [1762], 'is,': [1764], 'delayed': [1766], 'onset': [1767], 'drive': [1776, 1788], 'profile': [1782], 'paradoxically': [1786], 'their': [1789, 2734, 3029, 3819], 'poorer': [1790], 'outcomes.': [1791, 3055], 'Indeed,': [1792], 'comorbidities': [1808, 1834], 'diabetes,': [1811], 'history': [1812], 'failure,': [1815], 'stroke,': [1817], 'entirely': [1823], 'outcome.9,33': [1828], 'unaccounted': [1833], 'responsible': [1839], 'residual': [1842], 'Alternatively,': [1850], 'involved;': [1856], 'these,': [1858], 'social': [1859], 'psychological': [1861, 3002], 'rarely': [1864, 3044], 'considered.': [1866], 'remarkable': [1874], 'decrease': [1875, 2006], 'randomly': [1884], 'assigned': [1885], 'stress-reduction': [1888], 'intervention': [1889], 'specifically': [1890], 'tailored': [1891], 'women.34': [1893], 'Although': [1894, 2189], 'full': [1900], 'explanation': [1901], 'excess': [1904, 1916], 'narrowing,33': [1919], 'reflecting': [1920], 'sharper': [1922], 'decline': [1924, 1992, 2079], 'trend': [1933, 1966, 2122], 'suggests': [1934], 'environmental': [1936], 'behavioral': [1938, 3004], 'causes': [1939], 'biological': [1950, 2912], 'ones.The': [1951], 'declining': [1952], 'post-MI': [1956, 2622], 'consistent': [1962], 'decreasing': [1965, 2049], 'population': [1973, 2063], 'since': [1976], 'mid-1960s,': [1978], 'men.35': [1983], 'Yet,': [1984, 2299], 'countless': [1985], 'increase': [1996, 2057, 3095], 'concurrent': [2005], 'men.12,36–38': [2008], 'assertions': [2010], 'misinterpretation': [2015], 'statistics': [2018], 'plotted': [2021], 'disease.39': [2029], 'total': [2031], '(not': [2035], 'death': [2037, 4174], 'rate)': [2038], 'slightly': [2044], 'increased': [2045, 3089], 'while': [2048], 'year': [2054, 2102], '2000.': [2055], 'reflects': [2059], 'aging': [2061], 'US': [2062], 'fact': [2066, 2584], 'live': [2069], 'longer': [2070], 'age-standardized': [2074], 'over': [2084], 'past': [2086], 'United': [2091, 2106, 2776], 'States': [2092, 2777], 'countries': [2096], 'world.35,40,41': [2099], '2000,': [2103], 'States,': [2107], 'shown': [2115], 'steeper': [2120], 'downward': [2121], 'men.Are': [2127], 'With': [2129, 2260, 4161], 'Treated': [2132], 'Less': [2133], 'Aggressively': [2134], 'Men,': [2136], 'Does': [2138], 'Differential': [2139], 'Treatment': [2140], 'Contribute': [2141], 'Outcome': [2143], 'Differences?A': [2144], 'aggressive': [2146, 2629], 'relative': [2155, 2633], 'years,': [2162], 'refer': [2167], 'bias': [2172], 'health': [2174, 3266], 'care': [2175, 2197, 2611, 2625, 2736, 4171], 'delivery.': [2176, 2737], 'Most': [2177], 'conducted': [2183], 'ACS.': [2188, 2694], 'indisputable': [2192], 'variations': [2194, 2209], 'demographic': [2200], 'groups,': [2201], 'complex': [2211], 'variety': [2218], 'sex.': [2223], 'older,': [2230], 'biomarkers': [2235], 'cardiac': [2237, 2941, 3033], 'necrosis,': [2238], 'CAD.': [2244], 'Furthermore,': [2245, 2989], 'studies,': [2248], 'small.': [2256], 'Get': [2259, 4160], 'Guidelines–Coronary': [2262], 'Artery': [2263], '(GWTG-CAD)': [2265], 'database,': [2266, 2534], 'receipt': [2269], 'aspirin': [2271, 2295], 'β-blockers': [2273], 'percentage': [2281, 2547], 'points;': [2282], '93%': [2285], '91%': [2290], 'received': [2294], '24': [2297], 'hours.': [2298], 'presented': [2304], 'disparities.25': [2309], 'Similar': [2310], 'obtained': [2313], 'large': [2316, 2696, 2933], 'contemporary': [2317, 2783], 'databases,': [2318], 'CRUSADE,38': [2320], 'GRACE,42': [2321], 'NRMI,43': [2322], 'CURE': [2324], 'trial,44': [2325], 'Medicare': [2328], 'database.45': [2329], 'overstate': [2333, 2526], 'derive': [2339, 2408, 2688], 'excessive': [2342], 'reliance': [2343], 'P': [2345, 2366], 'values.': [2346], 'As': [2347, 2853], 'databases': [2352], 'continues': [2356], 'grow,': [2358], 'wary': [2362], 'highly': [2364], 'always': [2370], 'denote': [2371], 'meaningful': [2373], 'differences.Although': [2374], 'evidence-based': [2378, 2427], 'medications': [2379], 'almost': [2383], 'any': [2384, 2514, 2527], 'some': [2387], 'reperfusion': [2394], 'therapy': [2395], 'vary.25,43,45': [2402], 'gaps': [2404], 'bleeding': [2410], 'concerns': [2411], 'per': [2417], 'se.': [2418], 'Consistently': [2419], 'procedures,': [2428], 'catheterization': [2432, 2456], 'revascularization': [2434, 2755], 'procedures.38,43–45': [2435], 'interventions,': [2439], 'reflect': [2446], 'true': [2447, 3059], 'disparities.': [2448], 'prevalence': [2451], 'explains': [2457], 'use': [2460, 2536, 2574], 'revascularization,38,44': [2462], 'average,': [2466], 'underuse': [2467, 2479], 'procedures': [2470, 2483], 'necessarily': [2475], 'inappropriate.Another': [2476], 'indication': [2477], 'treatments': [2481, 2655, 3068], 'seem': [2501], 'account': [2503], 'ACS,': [2512], 'found.38,42,44,45': [2516], 'context': [2520], 'found.': [2529], 'French': [2532], 'half': [2544], 'point': [2548, 2732], 'still,': [2557], 'authors': [2559], 'concluded': [2560], 'quarter': [2563], 'gender': [2566, 3563], 'gap': [2567, 2698], 'related': [2571], 'intervention.46': [2578], 'conclusion': [2580], 'derived': [2581], 'age-adjusted': [2587], '<2%': [2592], 'population.In': [2595], 'database': [2598], 'Alter': [2603], 'al47': [2605], 'clearly': [2606, 2646], 'demonstrated': [2607], 'explaining': [2618, 3050], 'mortality.': [2623], 'Whereas': [2624], 'became': [2626], 'progressively': [2627], 'survival': [2636, 2662, 4199], 'advantage': [2637], 'tracked': [2638], 'opposite': [2641], 'direction,': [2642], 'favored.': [2647], 'findings': [2649], 'explored': [2658], 'determinants': [2660], 'men.It': [2669], 'noted': [2672], 'management': [2684, 2710, 4237, 4278], 'knowledge': [2697], 'involves': [2699], 'pectoris.': [2701], 'Little': [2702], 'angina,': [2712], 'its': [2714], 'manifestation': [2719], 'therefore,': [2725], 'representing': [2729], 'starting': [2731], 'Europe': [2741], 'receive': [2758], 'preventive': [2759], 'treatments48,49': [2760], 'presence': [2768], 'defects.48': [2771], 'Older': [2772], 'disparities,50–53': [2780], 'determine': [2788], 'still': [2795], 'present.ConclusionAfter': [2796], 'decade': [2800], 'renewed': [2802], 'interest': [2803], 'health,': [2807], 'answers.': [2815], 'Fundamental': [2816], 'unanswered.': [2828], 'gained': [2831], 'clues': [2833], 'basis': [2836], 'unique': [2847, 2927], 'female': [2850], 'system.': [2852, 2988], 'result,': [2855], 'yet': [2858], 'epidemiology,': [2866], 'Key': [2874], 'protected': [2881], 'protection': [2887, 2897], 'restricted': [2889], 'system,54': [2893], 'ends': [2898], 'diabetes': [2902], 'MI.': [2906], 'compare': [2911], 'define': [2922], 'processes': [2924, 2939], 'sufficiently': [2932], 'link': [2937], 'points.': [2943], 'focusing': [2947], 'estrogen,': [2949], 'pathways': [2951], 'now': [2953], 'considered;': [2955], 'physiology': [2964], 'pregnancy': [2966], 'menstruation,': [2968], 'regeneration': [2972], 'repair,': [2974], 'hormonal': [2975], 'estrogen': [2979], '(such': [2980], 'testosterone),': [2982], 'autonomic': [2983], 'function,': [2984], 'immune': [2987], 'nonbiological': [2993], 'detail.': [3000], 'Do': [3001], 'depression,': [3009], 'family/work': [3010], 'stress,': [3011], 'socioeconomic': [3012], 'deprivation,': [3013], 'early': [3015, 3465, 3675, 4173], 'life': [3016, 3436], 'adversities': [3017], 'increasing': [3028], 'events?': [3034], 'diagnostic': [3065], 'testing': [3066], 'current': [3079, 3207], 'era,': [3080], 'and,': [3081], 'so,': [3083], 'appropriate?': [3091], 'How': [3092], 'inclusion': [3097], 'trials?': [3103], 'Without': [3104], 'answer': [3106], 'improve': [3115], 'women.Guest': [3126], 'Editor': [3127], 'article': [3130], 'Paul': [3132], 'A.': [3133, 3663], 'Heidenreich,': [3134], 'MD.Sources': [3135], 'FundingDr': [3137], 'supported': [3140], 'grant': [3142], 'K24': [3143], 'HL077506-06': [3144], 'National': [3147, 3194, 3470, 3957, 4068, 4209], 'Institutes': [3148, 4069], 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