Title: Biogenesis of storage granules and vesicles
Abstract: The production of storage granules and vesicles that undergo regulated exocytosis occurs via biosynthetic and endocytotic pathways, respectively. Prominent in the formation of secretory granules in the Golgi apparatus is selective protein aggregation, which may account for the biogenesis of a multiple granules in a single cell. New cDNA transfection and immunolocalization studies have helped to further refine our understanding of the relationship between the formation of regulated secretory vesicles and the earlyh stages of the endocytotic pathway. Recent insights into the targeting of membrane proteins to these organelles have implicated both specific sortingb signals and protein-protein aggregation.
Publication Year: 1992
Publication Date: 1992-08-01
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 38
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