Physical Interaction between Epidermal Growth Factor Receptor and DNA-dependent Protein Kinase in Mammalian Cells

Name: Work Video:
Duration: 3 min 30 s
Debdutta Bandyopadhyay; Mahitosh Mandal; Liana Adam; John Mendelsohn; Rakesh Kumar
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2998, 3007, 3051, 3062, 3074, 3089, 3273, 3282, 3316, 3345, 3369, 3422, 3431, 3445, 3457, 3486, 3524, 3528, 3544, 3565, 3575, 3596, 3601, 3623, 3632, 3672, 3681, 3688, 3702, 3802, 3840, 3842, 3859, 3871, 3904, 3931, 3976, 3981, 4053, 4107, 4112, 4142, 4147, 4162, 4171, 4175, 4286, 4367, 4402, 4412, 4419, 4425, 4430, 4444, 4447, 4450, 4455, 4458, 4476], 'these': [19, 282, 2217, 3116, 3221, 4379], 'events': [20, 283], 'are': [21, 284, 533, 4225, 4260, 4325], 'inhibited': [22, 285, 1552], 'by': [23, 119, 124, 286, 382, 387, 535, 709, 857, 1115, 1553, 1955, 2264, 2337, 2372, 2441, 2521, 2718, 2924, 3134, 3340, 3364, 3429, 3455, 3526, 3720, 3889, 4173, 4295, 4307, 4317, 4323], 'monoclonal': [24, 75, 287, 338, 639, 679, 859], 'antibodies': [25, 76, 288, 339, 860, 4474], 'against': [26, 289, 890, 1798, 1965, 2299, 2563, 2616, 3139], 'EGFR.': [27, 180, 290, 443, 1845, 3682, 4494], 'Since': [28, 291, 1656, 1994], 'efficient': [29, 292, 1657], 'DNA': [30, 96, 253, 293, 359, 516, 1248, 1402, 1588, 1658], 'repair': [31, 254, 294, 517, 1243, 1659], 'in': [32, 63, 103, 110, 113, 127, 136, 153, 203, 216, 233, 243, 249, 256, 259, 295, 326, 366, 373, 376, 390, 399, 416, 466, 479, 496, 506, 512, 519, 522, 819, 868, 1081, 1250, 1284, 1313, 1393, 1584, 1729, 1732, 1739, 1753, 1815, 1821, 1913, 1934, 1944, 2044, 2117, 2121, 2148, 2159, 2193, 2205, 2346, 2367, 2405, 2492, 2832, 2852, 2902, 2915, 3044, 3086, 3115, 3159, 3335, 3386, 3410, 3495, 3611, 3675, 3704, 3724, 3735, 3812, 3856, 3863, 3875, 3892, 3901, 3936, 3958, 3973, 4035, 4046, 4050, 4063, 4072, 4086, 4234, 4270, 4288, 4311, 4319, 4352, 4371, 4394, 4404, 4471, 4497], 'actively': [33, 296], 'growing': [34, 297], 'cells': [35, 205, 298, 468, 612, 821, 935, 1286, 1731, 1757, 1823, 1918, 1952, 2018, 2038, 2207, 2224, 2280, 2322, 2393, 2437, 2469, 2640, 2686, 2730, 2755, 2835, 2857, 2919, 2934, 2985, 3096, 3228, 3255, 3259, 3306, 3428, 3478, 3561, 3580, 3706, 3831, 3911, 3985, 4116, 4134, 4194, 4253, 4291, 4304, 4340, 4374, 4434], 'may': [36, 246, 299, 509, 1660], 'require': [37, 300, 1661, 3661], 'signaling,': [40, 303], 'it': [41, 304, 1698], 'was': [42, 122, 149, 167, 305, 385, 412, 430, 1907, 2177, 2319, 2380, 2438, 2518, 2836, 3036, 3100, 3132, 3147, 3332, 3362, 3395, 3854, 3873, 3887, 3899, 4043, 4058, 4292, 4305, 4388], 'interest': [44, 307, 1701], 'explore': [46, 309, 1703], 'any': [47, 310, 1704], 'linkage': [48, 311, 1705], 'between': [49, 88, 161, 210, 312, 351, 424, 473, 1706, 1723, 2201, 2252, 2502, 2632, 2826, 2846, 2911, 3542, 3679, 3700, 3800, 4284], 'EGFR-mediated': [50, 313, 854, 1707], 'signaling': [51, 118, 232, 245, 314, 381, 495, 508, 1114, 1664, 1708], 'DNA-dependent': [53, 316, 645, 685, 1370], 'protein': [54, 317, 646, 686, 1371, 1807, 1842, 1943, 1968, 2050, 2154, 2174, 2236, 2254, 2386, 2411, 2428, 2459, 3130, 3384], 'kinase': [55, 191, 318, 454, 545, 926, 1283, 1308, 1372, 1377, 3047, 3079, 3303, 3337, 3663, 3674, 3691, 3971], '(DNA-PK),': [56, 319], 'an': [57, 320, 869, 1746, 1794, 1959, 2022, 2295, 2529], 'enzyme': [58, 321, 4094], 'believed': [59, 322, 1578], 'be': [61, 324, 1311, 1551, 1844, 2258, 2921, 3732], 'involved': [62, 325], 'repairing': [64, 327, 1585], 'double': [65, 328, 1586], 'strand': [66, 329, 1587], 'breaks': [67, 330, 1589], 'V(D)J': [69, 332, 1591, 1603], 'recombination.': [70, 333], 'We': [71, 334, 1712, 3665], 'report': [72, 335, 1713], 'that': [73, 143, 206, 336, 406, 469, 601, 1378, 1786, 1838, 1905, 1919, 2025, 2220, 2282, 2496, 2907, 3224, 3562, 3616, 3917, 4040, 4382], 'anti-EGFR': [74, 120, 154, 260, 337, 383, 417, 523, 858, 1070, 1116, 1735, 1781, 1853, 1960, 2032, 2226, 2284, 2343, 2396, 2485, 2531, 2693, 2803, 2930, 3004, 3015, 3058, 3230, 3319, 3604, 3815, 4395, 4452], '(mAbs),': [77, 340], 'not': [79, 175, 342, 438, 1738, 1820, 2190, 2342, 2377, 2402, 2622, 2627, 3217, 3234, 3624, 3655, 3696], 'EGFR': [80, 89, 117, 152, 162, 182, 211, 221, 231, 244, 343, 352, 380, 415, 425, 445, 474, 484, 494, 507, 628, 721, 925, 1085, 1113, 1314, 1724, 1742, 1912, 1942, 2124, 2204, 2262, 2336, 2351, 2370, 2427, 2503, 2515, 2628, 2633, 2827, 2847, 2862, 2912, 2975, 3035, 3043, 3077, 3085, 3142, 3236, 3242, 3249, 3302, 3331, 3361, 3400, 3464, 3543, 3564, 3617, 3651, 3660, 3662, 3673, 3690, 3701, 3801, 3872, 3918, 4124, 4285, 4393, 4401], 'ligands,': [81, 344, 2629, 3237], 'trigger': [82, 345, 2630], 'a': [83, 91, 104, 125, 144, 199, 227, 346, 354, 367, 388, 407, 462, 490, 1375, 1381, 1386, 1396, 1581, 1806, 1966, 2048, 2118, 2145, 2234, 2293, 2347, 2384, 2406, 2564, 2575, 3042, 3055, 3214, 3403, 3647, 3849, 3860, 3890, 3934, 3987, 4091, 4308, 4335, 4383], 'specific': [84, 347, 1719, 2199, 2837, 3137, 3990], 'early': [85, 348, 1720, 2230], 'physical': [86, 159, 208, 349, 422, 471, 1721, 2231, 2844, 3798], 'interaction': [87, 160, 350, 423, 1722, 1999, 2200, 2232, 2251, 2631, 2825, 2845, 2910, 3240, 3541, 3678, 3699, 3799, 4283], '350-kDa': [92, 355, 1382], 'catalytic': [93, 356, 642, 682, 1383, 1509, 1800, 2241], 'subunit': [94, 357, 643, 683, 1384, 1801], 'or': [97, 165, 186, 214, 360, 428, 449, 477, 715, 917, 1727, 2030, 2473, 2484, 2488, 2508, 2573, 2636, 2652, 2661, 2668, 2675, 2722, 2734, 2762, 2771, 2790, 2802, 2808, 2830, 2850, 2938, 2944, 2958, 2962, 2974, 2989, 3014, 3105, 3141, 3245, 3266, 3275, 3296, 3399, 3463, 3467, 3489, 3498, 3504, 3555, 3591, 3607, 4123, 4127, 4149, 4183, 4190, 4247, 4421, 4486, 4502], 'its': [98, 134, 189, 361, 397, 452, 808, 2001, 2265, 2338], 'regulatory': [99, 362, 1388, 2002, 2243], 'heterodimeric': [100, 363, 1387], 'complex': [101, 364, 1389], 'Ku70/80,': [102, 365], 'variety': [105, 368], 'types,': [108, 371], 'both': [109, 372, 921, 1598, 2240, 2395, 3087], 'vivo': [111, 374], 'vitro.': [114, 377, 3420], 'Inhibition': [115, 378], 'mAb': [121, 384, 1782, 1816, 1854, 1916, 1927, 1945, 1949, 1961, 2013, 2024, 2033, 2040, 2113, 2142, 2160, 2210, 2227, 2434, 2474, 2483, 2486, 2497, 2664, 2671, 2678, 2694, 2714, 2738, 2750, 2774, 2786, 2792, 2799, 2804, 2810, 2833, 2839, 2916, 2942, 2993, 3005, 3011, 3016, 3093, 3106, 3151, 3231, 3278, 3293, 3298, 3320, 3373, 3446, 3493, 3522, 3592, 3605, 3619, 3822, 3835, 3885, 3914, 3982, 4056, 4079, 4098, 4113, 4156, 4169, 4191, 4248, 4289, 4299, 4337, 4345, 4372, 4415, 4423, 4441, 4467, 4477], 'accompanied': [123, 386, 3888, 4059, 4306], 'reduction': [126, 389, 2120, 3891, 3957, 4062, 4310], 'the': [128, 131, 137, 170, 177, 196, 236, 250, 257, 391, 394, 400, 433, 440, 459, 499, 513, 520, 596, 603, 863, 891, 902, 909, 1084, 1112, 1242, 1246, 1275, 1307, 1407, 1417, 1508, 1514, 1714, 1749, 1799, 1829, 1836, 1839, 1938, 1974, 2027, 2149, 2198, 2249, 2269, 2425, 2455, 2500, 2523, 2707, 2814, 2908, 2980, 3021, 3081, 3110, 3125, 3128, 3155, 3380, 3393, 3432, 3473, 3496, 3540, 3597, 3667, 3677, 3689, 3698, 3714, 3721, 3736, 3806, 3819, 3825, 3857, 3864, 3876, 3893, 3902, 3921, 3937, 3940, 3955, 3959, 3962, 3969, 3974, 4047, 4064, 4067, 4076, 4082, 4087, 4228, 4263, 4271, 4312, 4320, 4329, 4356, 4391, 4491], 'levels': [129, 178, 238, 392, 441, 501, 1939, 2150, 2326, 4065], 'DNA-PK': [132, 148, 164, 185, 213, 395, 411, 427, 448, 476, 1503, 1546, 1576, 1710, 1726, 1752, 1803, 1848, 1997, 2176, 2202, 2256, 2505, 2517, 2635, 2829, 2849, 2914, 2955, 2971, 3010, 3113, 3140, 3158, 3398, 3416, 3421, 3460, 3554, 3574, 3631, 3634, 3680, 3703, 3803, 3811, 3853, 3925, 3942, 3964, 3970, 3992, 4041, 4069, 4085, 4120, 4198, 4257, 4287, 4315, 4344, 4387, 4403], 'activity': [135, 255, 398, 518, 546, 927, 1309, 1544, 3156, 3972, 4042, 4083, 4199, 4232], 'nuclear': [138, 237, 401, 500, 3843, 3896, 3905, 3941, 3963, 3977, 4048, 4068, 4108, 4163, 4184, 4330, 4501], 'fraction.': [139, 402, 4236], 'Confocal': [140, 403], 'imaging': [141, 404], 'revealed': [142, 405, 4381], 'substantial': [145, 408, 4384], 'amount': [146, 409, 3938, 3960, 4239, 4313, 4385], 'co-localized': [150, 413, 4389], 'mAb-treated': [155, 261, 418, 524, 4396], 'cells.': [156, 262, 419, 525, 2291, 3451, 3573, 4406], 'Anti-EGFR': [157, 420, 1268], 'mAb-induced': [158, 421], 'Ku70/80': [166, 187, 215, 429, 450, 478, 1390, 1728, 2028, 2053, 2489, 2509, 2809, 2831, 2851, 2959, 3423, 3556, 3576], 'dependent': [168, 431], 'on': [169, 176, 432, 439, 1748, 1828, 2276, 3154, 3824, 4081, 4100, 4410], 'presence': [171, 434, 3497], 'EGFR,': [173, 436, 633, 673, 804, 895, 2461, 3717], 'but': [174, 437, 1306, 1819, 2341, 3233], 'The': [181, 444, 526, 589, 1069, 1487, 1497, 1533, 1543, 1575, 1646, 1931, 2512, 3076, 3356, 3683, 3785], 'retains': [188, 451], 'intrinsic': [190, 453, 544, 3046], 'activity.': [192, 455, 3664, 4070, 4258], 'Our': [193, 223, 456, 486, 3795], 'findings': [194, 457], 'demonstrate': [195, 458, 2197, 2906, 3615, 4039], 'existence': [197, 460], 'novel': [200, 463], 'cellular': [201, 464, 1107], 'pathway': [202, 465], 'mammalian': [204, 467, 1730], 'involves': [207, 470], 'interactions': [209, 472], 'response': [217, 480, 1733, 1740, 3813], 'inhibition': [219, 482, 1072, 1119, 1240], 'signaling.': [222, 485, 3652], 'present': [224, 487, 3874], 'observations': [225, 488, 2218], 'suggest': [226, 489], 'possible': [228, 491], 'role': [229, 492, 1583], 'maintenance': [234, 497], 'DNA-PK,': [240, 503, 641, 681, 3545, 3829], 'interference': [242, 505, 849], 'possibly': [247, 510], 'result': [248, 511], 'impairment': [251, 514], 'nuclei': [258, 521], 'mitogenic': [527], 'effects': [528, 1108], 'stimulatory': [531], 'polypeptides': [532], 'regulated': [534], 'their': [536], 'binding': [537, 914, 1403], 'high': [539, 905], 'affinity': [540, 906], 'transmembrane': [541], '(1Yarden': [547, 732], 'Y.': [548, 733, 1053, 1090, 1127, 1290], 'Ullrich': [549, 734, 828, 2544, 2879, 3997], 'A.': [550, 563, 735, 748, 829, 836, 943, 969, 982, 1131, 1133, 1204, 1329, 1612, 1682, 1686, 1861, 1874, 2071, 2084, 2545, 2880, 3189, 3204], 'Annu.': [551, 615, 736, 776], 'Rev.': [552, 616, 737, 777], 'Biochem.': [553, 617, 738, 778, 1445, 3743], '1988;': [554, 739, 837], '57:': [555, 740], '443-478Crossref': [556, 741], 'PubMed': [557, 573, 584, 621, 742, 758, 769, 782, 797, 961, 986, 1008, 1047, 1142, 1166, 1219, 1263, 1347, 1367, 1435, 1453, 1468, 1570, 1627, 1676, 1774, 1878, 1900, 1989, 2088, 2110, 2314, 2557, 2890, 3181, 3208, 3751, 3766, 4009, 4029, 4219], 'Scopus': [558, 574, 585, 622, 743, 759, 770, 783, 798, 840, 987, 1143, 1167, 1220, 1264, 1436, 1454, 1469, 1571, 1628, 1677, 1775, 1879, 1990, 2089, 2315, 2558, 2891, 3182, 3209, 3752, 3767, 4010, 4030, 4220], '(1384)': [559, 744], 'Google': [560, 576, 587, 624, 745, 761, 772, 785, 800, 842, 883, 962, 989, 1009, 1028, 1048, 1067, 1104, 1145, 1169, 1222, 1237, 1266, 1304, 1348, 1368, 1438, 1456, 1471, 1573, 1630, 1679, 1696, 1777, 1881, 1901, 1992, 2091, 2111, 2317, 2560, 2613, 2893, 3184, 3211, 3754, 3769, 4012, 4032, 4222], 'Scholar,': [561, 577, 746, 762, 773, 786, 963, 990, 1010, 1029, 1049, 1223, 1349, 1439, 1457, 1472, 1631, 1680, 1882, 2092, 2561, 2614, 3185, 3755, 3770, 4013], '2Ullrich': [562, 747], 'Schlessinger': [564, 749, 2548, 2881], 'J.': [565, 750, 827, 876, 951, 952, 971, 975, 998, 999, 1014, 1016, 1033, 1038, 1057, 1058, 1094, 1095, 1135, 1136, 1159, 1160, 1175, 1187, 1198, 1211, 1212, 1227, 1231, 1253, 1256, 1294, 1295, 1337, 1338, 1353, 1358, 1476, 1522, 1559, 1606, 1619, 1620, 1635, 1666, 1669, 1767, 1768, 1863, 1867, 1890, 1891, 2073, 2077, 2100, 2101, 2307, 2549, 2882, 3170, 3774, 4018, 4208], 'Cell.': [566, 751, 1430, 2309, 2550, 2883, 4004], '1990;': [567, 752, 880, 1432], '61:': [568, 753], '203-212Abstract': [569, 754], 'Full': [570, 755, 958, 1005, 1044, 1064, 1101, 1301, 1344, 1364, 1450, 1465, 1565, 1567, 1897, 2107, 2554, 2887, 3176, 3178, 3748, 3763, 4024, 4026, 4214, 4216], 'Text': [571, 756, 959, 1006, 1045, 1065, 1102, 1302, 1345, 1365, 1451, 1466, 1566, 1568, 1898, 2108, 2555, 2888, 3177, 3179, 3749, 3764, 4025, 4027, 4215, 4217], 'PDF': [572, 757, 960, 1007, 1046, 1066, 1103, 1303, 1346, 1366, 1452, 1467, 1569, 1899, 2109, 2556, 2889, 3180, 3750, 3765, 4028, 4218], '(4583)': [575, 760], '3Aaronson': [578, 763], 'S.A.': [579, 764], 'Science.': [580, 765], '1991;': [581, 766, 794, 1002, 1693, 1894, 2104, 2311], '254:': [582, 767], '1146-1153Crossref': [583, 768], '(1150)': [586, 771], 'Scholar).': [588, 625, 801, 843, 884, 1068, 1105, 1267, 1496, 1542, 1574, 1655, 1902, 1993, 3794, 4033, 4223], 'is': [593, 1374, 1577, 1699, 3351, 3646, 3965, 4469], 'one': [594, 3327], 'well': [597, 806], 'characterized': [598], 'stimulates': [602], 'proliferation': [604, 731, 874, 1075], 'fibroblasts': [606], 'most': [608], 'types': [609], 'epithelial': [611], '(4Carpenter': [613], 'G.': [614, 775], '1987;': [618, 779, 2884], '56:': [619, 780], '881-914Crossref': [620, 781], '(1042)': [623, 784], 'Modifications': [626], '1The': [629, 669], 'abbreviations': [630, 670], 'used': [631, 671, 3068], 'are:': [632, 672], 'receptor;': [637, 677], 'mAb,': [638, 678], 'antibodies;': [640, 680], 'kinase;': [647, 687], 'TGF,': [648, 688], 'transforming': [649, 689], 'factor;': [651, 691], 'PI,': [652, 692], 'phosphatidylinositol;': [653, 693], 'PMSF,': [654, 694], 'phenylmethylsulfonyl': [655, 695], 'fluoride;': [656, 696], 'PAGE,': [657, 697], 'polyacrylamide': [658, 698], 'gel': [659, 699], 'electrophoresis;': [660, 700], 'FITC,': [661, 701], 'fluorescein': [662, 702], 'isothiocyanate;': [663, 667, 703, 707], 'TRITC,': [664, 704], 'tetramethylrhodamine': [665, 705], 'B': [666, 706, 1936, 2905], 'immunoprecipitation.': [668], 'immunoprecipitation.induced': [708], 'such': [712], 'as': [713, 805, 807, 1593, 1953, 2460, 2698, 3213, 3718, 4090, 4200, 4227, 4262], 'EGF': [714], 'TGF-α': [716, 916, 2272, 2373, 2472, 2656, 2766, 3104, 3270, 3312], 'lead': [717], 'engagement': [719], 'mitogenesis': [728], '4Carpenter': [774], '5Kumar': [787], 'R.': [788, 790, 996, 1022, 1037, 1178, 1190, 1357, 1888, 2098, 2303], 'Mendelsohn': [789, 950, 974, 997, 1013, 1032, 1056, 1093, 1134, 1158, 1210, 1230, 1293, 1336, 1352, 1618, 1766, 1866, 1889, 2076, 2099, 2306], 'Curr.': [791], 'Opin.': [792], 'Oncol.': [793], '3:': [795], '70-74Crossref': [796], '(14)': [799], 'Overexpression': [802], 'natural': [809, 910], 'ligand': [810, 1278, 2339], 'TGF-α,': [811, 2340], 'has': [812, 1076, 1547, 3635, 3728, 3804], 'been': [813, 862, 897, 1077, 1271, 1548, 1921, 3636, 3729], 'shown': [814, 898, 1272, 1549, 3352, 3637, 3730, 4470], 'induce': [816], 'transformed': [817], 'properties': [818], 'recipient': [820], '(6Reidel': [822], 'H.': [823, 947, 1020, 1035, 1155, 1202, 1229, 1333, 1355, 1610, 1763], 'Massoglia': [824], 'S.': [825, 835, 981, 1428, 1873, 2083, 2871, 3203], 'Scjlessinger': [826], 'Proc.': [830, 976, 1868, 2078, 3198], 'Natl.': [831, 977, 1213, 1257, 1621, 1670, 1869, 2079, 3199], 'Acad.': [832, 978, 1870, 2080, 3200], 'Sci.': [833, 979, 1446, 1871, 2081, 3201, 3744], 'U.': [834, 980, 1872, 2082, 3202], '5:': [838], '1477-1481Crossref': [839], '(96)': [841], 'In': [844, 2215, 2365, 4377], 'recent': [845], 'years,': [846], 'approaches': [847], 'involving': [848, 3551], 'and/or': [851], 'blocking': [852], 'stimulation': [856, 930], 'have': [861, 896, 1270, 2323, 3639], 'subject': [864], 'active': [866], 'investigation': [867, 1747], 'effort': [870], 'control': [872, 1822, 2011, 2945, 2963, 3061, 3444, 3590, 3608, 3980, 4051, 4111, 4189, 4244], '(7Mendelsohn': [875], 'Semin.': [877], 'Cancer': [878, 1023, 1214, 1232, 1258, 1622, 1671, 1691, 2608], 'Biol.': [879, 953, 1000, 1039, 1059, 1096, 1138, 1296, 1339, 1359, 1431, 1560, 1892, 2102, 2310, 3171, 4005, 4019, 4209], '1:': [881], '339-344PubMed': [882], 'mAbs': [885, 1117, 1269, 1321, 1736, 2285, 2397, 2978, 3138, 3471], '528': [886, 1855, 2672, 2695, 3006, 3321], '225,': [888, 1783, 2840, 3232], 'raised': [889, 1964, 2562, 2615, 3805], 'domain': [893, 1976, 2618], 'bind': [900], 'comparable': [907], 'ligand,': [911, 2266], 'compete': [912], 'for': [913, 1181, 1193, 2212, 2476, 2646, 2682, 2740, 2758, 2947, 2995, 3262, 3313, 3437, 3483, 3509, 3583, 3837, 3991, 4139, 4158, 4197, 4256, 4427, 4490], 'EGF,': [918, 2375], 'block': [920, 1274], 'ligand-induced': [922], 'activation': [923, 1995, 2263, 2334, 2371], 'normal': [932], 'malignant': [934], '(8Gill': [936, 1322], 'G.N.': [937, 1323], 'Kawamoto': [938, 1324], 'T.': [939, 965, 1325, 1420, 1857, 2067], 'Cochet': [940, 1326], 'C.': [941, 1327], 'Le': [942, 968, 1328, 1860, 2070], 'Sato': [944, 966, 972, 1330, 1858, 1864, 2068, 2074], 'J.D.': [945, 967, 1331, 1486, 1532, 1645, 1859, 2069, 3784], 'Masui': [946, 1019, 1034, 1154, 1201, 1228, 1332, 1354, 1609, 1762], 'MacLeod': [948, 1334], 'C.I.': [949, 1335], 'Chem.': [954, 1001, 1040, 1060, 1097, 1297, 1340, 1360, 1561, 1893, 2103, 3172, 4020, 4210], '1984;': [955, 1341], '259:': [956, 1342], '7755-7760Abstract': [957, 1343], '9Kawamoto': [964], 'Polikoff': [970, 1862, 2072], 'G.H.': [973, 1865, 2075], '1983;': [983, 1875, 2085], '80:': [984, 1876, 2086], '1337-1341Crossref': [985, 1877, 2087], '(687)': [988, 1880, 2090], '10Van': [991, 1883, 2093], 'de': [992, 1884, 2094], 'Vijver': [993, 1885, 2095], 'M.J.': [994, 1886, 2096], 'Kumar': [995, 1021, 1036, 1356, 1887, 2097], '266:': [1003, 1895, 2105], '7503-7508Abstract': [1004, 1896, 2106], '11Atlas': [1011], 'I.': [1012, 1422, 1424, 1684, 2539], 'Baselga': [1015, 1226], 'Fair': [1017], 'W.R.': [1018], 'Res.': [1024, 1233, 1692, 2609], '1992;': [1025, 4006], '52:': [1026], '3335-3339PubMed': [1027], '12Fan': [1030, 1350], 'Z.': [1031, 1051, 1088, 1125, 1153, 1225, 1255, 1288, 1351, 1668, 1690, 1761], '1993;': [1041, 1061, 1098, 1216, 1234, 1298, 1361, 1624], '268:': [1042, 1362], '21073-21079Abstract': [1043, 1363], '13Fan': [1050], 'Lu': [1052, 1089, 1126, 1289], 'Wu': [1054, 1091, 1128, 1291], 'X.': [1055, 1092, 1129, 1151, 1292, 1759], '269:': [1062, 1099, 1299], '27595-27602Abstract': [1063, 1100, 1300], 'mAb-mediated': [1071], 'attributed,': [1078], 'at': [1079], 'least': [1080], 'part,': [1082], 'dimerization': [1086], '(13Fan': [1087, 1287], 'Other': [1106], 'blockade': [1110], 'include': [1118], 'cycle': [1122], 'progression': [1123], '(14Fan': [1124], 'DeBlasio': [1130], 'Koff': [1132], 'Cell': [1137, 2688, 2704, 2743, 2780, 2950, 3516], '1995;': [1139, 1163, 1447, 1462, 1771, 2610, 3173, 3205, 3745, 3760, 4211], '131:': [1140], '235-242Crossref': [1141], '(132)': [1144], 'Scholar),': [1146, 1170, 1238, 1305, 1697, 2112], 'induction': [1147], 'apoptosis': [1149], '(15Wu': [1150, 1758], 'Fan': [1152, 1254, 1667, 1760], 'Rosen': [1156, 1764], 'N.': [1157, 1765], 'Clin.': [1161, 1769], 'Invest.': [1162, 1770], '95:': [1164, 1772], '1897-1905Crossref': [1165, 1773], '(366)': [1168, 1776], '2M.': [1171, 1183], 'Mandal,': [1172, 1184], 'L.': [1173, 1185, 1200, 1480, 1526, 1608, 1639, 1688, 3778], 'Adam,': [1174, 1186], 'Mendelsohn,': [1176, 1188], 'Kumar,': [1179, 1191], 'submitted': [1180, 1192], 'publication.': [1182, 1194], 'enhanced': [1195], 'chemosensitization': [1196], '(17Baselga': [1197, 1605], 'Norton': [1199, 1607], 'Pandiella': [1203, 1611], 'Coplan': [1205, 1613], 'K.': [1206, 1614, 3996], 'Miller': [1207, 1615], 'Jr.,': [1208, 1616], 'W.M.': [1209, 1617], 'Inst.': [1215, 1259, 1623, 1672], '85:': [1217, 1625], '1327-1333Crossref': [1218, 1626], '(404)': [1221, 1629], '18Fan': [1224], '53:': [1235], '4637-4642PubMed': [1236], 'efficiency': [1244], 'damaged': [1247], '(reviewed': [1249], 'Ref.': [1251, 2865], '19Mendelsohn': [1252], '1997;': [1260, 1673], '89:': [1261, 1674], '341-343Crossref': [1262, 1675], '(165)': [1265, 1678], 'capacity': [1276, 3082], 'receptor': [1281, 2301], 'tyrosine': [1282, 3078], 'intact': [1285], 'can': [1310, 1392], 'detected': [1312, 2260, 2923, 4480], 'precipitated': [1315, 3330, 3360], 'from': [1316, 1847, 2010, 2063, 2135, 2433, 2467, 2706, 2813, 2979, 3020, 3060, 3092, 3348, 3426, 3443, 3472, 3557, 3571, 3578, 3589, 3618, 3625, 3979, 4110, 4188, 4243], 'lysates': [1318, 1792, 1914, 1947, 2009, 2163, 2466, 2689, 2705, 2744, 2781, 2928, 2951, 3000, 3066, 3288, 3442, 3517, 3570, 3588], 'anti-receptor': [1320], 'Scholar).The': [1369], '(DNA-PK)': [1373, 1804, 4366], 'serine/threonine': [1376], 'consists': [1379], 'vitro': [1394, 3045, 3336], 'phosphorylate': [1395], 'number': [1397], 'transcription': [1399], 'factors': [1400], 'proteins,': [1404], 'including': [1405], 'p53,': [1406], 'RNA': [1408], 'polymerase': [1409], 'II': [1410], 'carboxyl-terminal': [1411, 1498], 'domain,': [1412], 'replication': [1413], 'A,': [1415, 2358, 2416, 2449, 2638, 2896, 3071, 3119, 3253, 3868, 3880, 4105], 'Ku': [1418], '(20Carter': [1419], 'Vancurova': [1421], 'Sun': [1423], 'Lou': [1425], 'W.': [1426, 2541], 'DeLeon': [1427], 'Mol.': [1429, 2308, 4003], '10:': [1433], '6460-6471Crossref': [1434], '(245)': [1437], '21Jackson': [1440], 'S.P.': [1441, 1558, 3739, 3994, 4017], 'Jeggo': [1442, 3740], 'P.A.': [1443, 2589, 3741], 'Trends': [1444, 1460, 3742, 3758], '20:': [1448, 3746], '412-415Abstract': [1449, 3747], '(342)': [1455, 3753], '22Weaver': [1458, 3756], 'D.T.': [1459, 3757], 'Genet.': [1461, 3759], '11:': [1463, 2312, 3761], '388-392Abstract': [1464, 3762], '(191)': [1470, 3768], '23Reeves': [1473, 1632, 3771], 'W.H.': [1474, 1520, 1633, 3772], 'Wang': [1475, 1521, 1634, 3773], 'Ajmani': [1477, 1523, 1636, 3775], 'A.K.': [1478, 1524, 1637, 3776], 'Stojanov': [1479, 1525, 1638, 3777], 'Satoh': [1481, 1527, 1640, 3779], 'M.': [1482, 1484, 1528, 1530, 1641, 1643, 2547, 3191, 3780, 3782], 'Zanetti': [1483, 1529, 1642, 3781], 'Capra': [1485, 1531, 1644, 3783], 'Antibodies.': [1488, 1534, 1647, 3786], '3.': [1489, 1535, 1648, 3787], 'Harwood': [1490, 1536, 1649, 3788], 'Academy': [1491, 1537, 1650, 3789], 'Publishers,': [1492, 1538, 1651, 3790], 'Amsterdam,': [1493, 1539, 1652, 3791], 'Netherlands1997:': [1494, 1540, 1653, 3792], '33-84Google': [1495, 1541, 1654, 3793], '380': [1499], 'amino': [1500, 1971, 2568], 'acids': [1501, 1972, 2569], 'exhibits': [1504], 'sequence': [1505], 'homology': [1506, 3641], 'domains': [1510], 'members': [1512], 'phosphatidylinositol': [1515], '(PI)': [1516], '3-kinase': [1517, 3671, 3685], 'superfamily': [1518], '(23Reeves': [1519], 'autophosphorylation': [1554], '(24Chan': [1555], 'D.W.': [1556], 'Lees-Miller': [1557, 4016], '1996;': [1562, 1986, 4021], '271:': [1563, 4022], '8936-8941Abstract': [1564, 4023], '(239)': [1572], 'play': [1580], 'major': [1582, 3850], 'recombination,': [1592], 'mutations': [1594], 'DNA-PKcs': [1596, 2157, 2413, 3244], 'cause': [1597], 'x-ray': [1599], 'sensitivity': [1600], 'defective': [1602], 'recombination': [1604], '(19Mendelsohn': [1665], '25Haimovitz-Friedman': [1681], 'Vlodavsky': [1683], 'Chaudhuri': [1685], 'Witte': [1687], 'Fuks': [1689], '51:': [1694, 2885], '2552-2558PubMed': [1695], 'pathway.': [1711], 'results': [1715, 3222, 4380], 'experiments': [1717, 3550], 'demonstrating': [1718], 'ligands.RESULTS': [1743], 'AND': [1744], 'DISCUSSIONDuring': [1745], 'expression': [1750], 'DiFi': [1754, 1951, 2017, 2037, 2206, 2223, 2279, 2321, 2392, 2436, 2468, 2639, 2729, 2754, 3095, 3227, 3254, 3258, 3477, 3705, 3830, 3910, 3984, 4115, 4133, 4193, 4252, 4303, 4339, 4405], 'human': [1755, 2861, 3559], 'colorectal': [1756], 'Scholar)2': [1778], 'treated': [1779, 2208, 2470, 2650, 2732, 2757, 2936, 2987, 3257, 3261, 3308, 3487, 3833, 3912, 4143, 4413], 'we': [1784, 1834, 2267, 2462, 3039, 3546, 3967], 'observed': [1785, 1840, 2179, 2250, 2909, 3956, 4282], 'immunoprecipitation': [1787, 2925], '(IP)': [1788], '35S-labeled': [1790, 2007, 2728], 'antibody': [1795, 2297, 2533], '(clone': [1796, 1962], '25-4)': [1797], 'co-immunoprecipitated': [1805], 'approximate': [1809], 'molecular': [1810], 'mass': [1811], '170': [1813, 1832], 'kDa': [1814], '225-treated': [1817, 1917, 1946, 1950, 2014, 2161, 2435, 2834, 2917, 3094, 3447, 3593, 3620, 3983, 4114, 4192, 4249, 4290, 4338, 4373], 'cells,': [1818, 3595, 3622, 3628, 4052], '(Fig.': [1824, 1928, 2054, 2125, 2164, 2329, 2356, 2414, 2447, 3069, 3143, 3866, 3878, 3926, 3943, 4346], '1': [1825, 1929, 2055, 2126, 2165, 2195, 3073, 3323], 'A).': [1826, 3098], 'Based': [1827], 'size': [1830], 'kDa,': [1833], 'explored': [1835], 'possibility': [1837, 3807], 'DNA-PK-associated': [1841, 3034], 'could': [1843, 2257, 2920], 'Supernatants': [1846], 'IP': [1849, 1924], 'were': [1850, 2019, 2641, 2690, 2710, 2731, 2745, 2756, 2782, 2935, 2952, 2986, 3001, 3067, 3256, 3260, 3289, 3307, 3424, 3434, 3453, 3479, 3518, 3581, 3599, 3832, 3845, 4117, 4135, 4165, 4195, 4254, 4341, 4408, 4435, 4479], 're-immunoprecipitated': [1851], '(9Kawamoto': [1856, 2066], 'Results': [1903, 2192, 2491, 3610, 4034, 4224, 4259, 4351], 'indicated': [1904, 2219, 3916], 'there': [1906, 2379], 'almost': [1908], 'complete': [1909], 'absence': [1910, 3499], 'had': [1920], 'subjected': [1922, 3333], 'anti-DNA-PK': [1926, 2141, 2183, 2431, 2482, 2785, 2798, 3050, 3088, 3292, 3521, 4168, 4440], 'B).': [1930, 2331, 3145], 'lower': [1932, 2450, 3413], 'panel': [1933], 'Fig.1': [1935, 3411], 'shows': [1937], 'total': [1941, 4231, 4264], 'determined': [1954], 'direct': [1956], 'immunoblotting': [1957, 3135], '11E8,': [1963], 'fusion': [1967], 'containing': [1969], '330': [1970], 'cytoplasmic': [1975], 'EGFR)': [1978, 2238, 2572, 2620, 4369], '(39Morrison': [1979], 'P.': [1980], 'Chung': [1981], 'K.-C.': [1982], 'Rosner': [1983], 'M.R.': [1984, 2605], 'Biochemistry.': [1985], '35:': [1987], '14618-14624Crossref': [1988], '(17)': [1991], 'requires': [1998], 'subunits': [2003, 2244], 'Ku70': [2004], 'Ku80,': [2006], '(3': [2015], 'h)': [2016], 'immunoprecipitated': [2020, 2691, 2711, 2746, 2783, 2953, 3002, 3290, 3317, 3519, 4166], 'anti-Ku70/80': [2023, 2791, 3297], 'recognizes': [2026], 'heterodimer': [2029], '528.': [2034], 'Treatment': [2035, 2390, 3883], '225': [2041, 2114, 2211, 2228, 2286, 2398, 2475, 2498, 2665, 2775, 2943, 2994, 3107, 3152, 3279, 3494, 3823, 3836, 3886, 3915, 4057, 4080, 4099, 4157, 4300, 4416, 4468], 'also': [2042, 2178, 2259, 2519, 2842, 2922, 3932], 'resulted': [2043, 2116, 2345, 2404, 3347], 'increased': [2045, 2354], 'association': [2046, 2408, 2501, 2513], '170-kDa': [2049, 2153, 2173, 2235, 2253, 2385, 2410, 2426, 2458], 'band': [2051, 2155, 2387, 2429, 3722], 'C,': [2056, 2127, 2166, 3415, 4177, 4443], 'lanes': [2057, 2128, 2136, 2167, 2361, 2419, 2897, 3072, 3120, 3725], '5': [2058, 3272, 3726, 3867, 3879, 3927, 3944, 4037], '6).': [2060, 2511, 2779], 'As': [2061, 2292, 2332, 3054, 3301, 3709, 3847, 4334], 'expected': [2062], 'previous': [2064], 'studies': [2065], 'treatment': [2115, 2221, 2273, 3108, 3153, 3225, 4054, 4301], 'modest': [2119], 'newly': [2122], 'synthesized': [2123], '3and': [2129], '4).': [2130], 'However,': [2131], 're-IP': [2132], 'supernatants': [2134], '3': [2137, 2647, 2777, 2904, 3484, 4140], '4': [2139, 2420, 3070, 3144, 3281, 3613, 3948], '25-4': [2143, 2715, 2787, 4170], 'demonstrated': [2144, 3223, 3719], 'significant': [2146, 3640, 4309], 'increase': [2147], 'co-IP': [2152, 2382], 'only': [2158], '7': [2168], '8).': [2170], 'Co-immunoprecipitation': [2171], 'of35S-labeled': [2172, 3909], 'two': [2181], 'other': [2182], 'mAbs,': [2184, 2344, 2625, 3401], 'clones': [2185], '18-2': [2186], '42-psc': [2188], '(data': [2189, 2621, 3216], 'shown).': [2191, 3218], 'Fig.': [2194, 2493, 2903, 3612, 4036, 4353], 'D': [2196, 4074], '30': [2213, 2477, 2654, 2662, 2669, 2676, 2683, 2736, 2741, 2759, 2764, 2772, 2940, 2948, 2991, 2996, 3263, 3268, 3276, 3310, 3491, 3510, 3838, 4154, 4159, 4428], 'min.': [2214, 2742, 2949, 4160], 'brief,': [2216, 4378], 'triggers': [2229], '(presumably': [2237], 'DNA-PK.To': [2246], 'examine': [2247, 3818], 'whether': [2248, 3033, 3954], 'during': [2261], 'compared': [2268], 'effect': [2270, 3102, 3149, 3820, 4077], '(30': [2274, 2289, 3448], 'min)': [2275, 2290], 'metabolically': [2277, 2642], 'labeled': [2278, 2643, 3480, 4136], '528-treated': [2288], 'control,': [2294, 3057, 3304, 4336], 'unrelated': [2296], '4D5': [2298, 2679, 2739], 'HER2': [2300, 2328], '(29Kumar': [2302], 'Shepard': [2304], 'H.M.': [2305], '979-986Crossref': [2313], '(116)': [2316], 'Scholar)': [2318, 2894, 3212], 'used.': [2320], 'easily': [2324], 'detectable': [2325, 2440], '2': [2330, 2357, 2362, 2415, 2448, 2494, 2658, 2768, 2898, 3438, 3584, 4146], 'expected,': [2333, 3710, 3848], 'mobility': [2348], 'shift': [2349, 3723], 'due': [2352, 4361, 4465], 'phosphorylation': [2355, 3114, 3715], 'upper': [2359, 3869, 4446], 'panel,': [2360, 2418], '3).': [2364, 3951], 'contrast,': [2366], 'spite': [2368], '(or': [2374], 'data': [2376], 'shown),': [2378], 'no': [2381, 3101, 3148], 'DNA-PK.': [2389, 3252, 3897, 4104], '528,': [2400], '4D5,': [2403], 'rapid': [2407], 'middle': [2417, 3881, 4457], '5).': [2422, 2900], 'Association': [2423], 'immunoprecipitates': [2432, 3059, 3091, 3577], 'readily': [2439], 'staining': [2442, 4464], 'Coomassie': [2444], 'Brilliant': [2445, 2724], 'Blue': [2446, 2725], 'panel).': [2451, 2703, 3355, 3376, 3414, 3882], 'To': [2452, 3817, 3952], 'further': [2453, 3435, 3538, 4293], 'establish': [2454], 'identity': [2456, 3126, 3381], 'next': [2463, 3040, 3547], 'immunprecipitated': [2464], 'min': [2478, 2684, 2760, 3264, 3315, 3511, 4429], 'immunoblotted': [2480, 3370, 3458, 3602, 4118], '11E8': [2487, 2805, 3017, 3606], 'mAb.': [2490], 'Cconfirmed': [2495], 'induces': [2499], '(lane': [2506, 2510, 2666, 2673, 2680, 2966], '3)': [2507, 2660, 4153], 'established': [2520], 'stripping': [2522], 'above': [2524, 2708], 'blots': [2525], 're-immunoblotting': [2527], 'another': [2530, 2748], 'polyclonal': [2532], 'RK2': [2534], '(Ref.': [2535, 2579], '40Kris': [2536], 'R.M.': [2537], 'Lax': [2538], 'Gullick': [2540], 'Waterfield': [2542], 'M.D.': [2543], 'Fridkin': [2546], '1985;': [2551], '40:': [2552], '619-625Abstract': [2553], '(161)': [2559], 'peptide': [2565, 3988, 4272], 'corresponding': [2566], '985–996': [2570], 'different': [2576], 'anti-EGFR-mAb': [2577], 'H11': [2578], '41Wikstrand': [2580], 'C.J.': [2581, 2599], 'Hale': [2582], 'L.P.': [2583], 'Batra': [2584], 'S.K.': [2585], 'Hill': [2586], 'M.L.': [2587], 'Humphrey': [2588], 'Kurpad': [2590], 'S.N.': [2591], 'McLendon': [2592], 'R.E.': [2593], 'Moscatello': [2594], 'D.': [2595, 2877, 4472], 'Pegram': [2596], 'C.N.': [2597], 'Reist': [2598], 'Traweek': [2600], 'S.T.': [2601], 'Wong': [2602], 'A.J.': [2603], 'Zalutsky': [2604], 'Bigner': [2606], 'D.D.': [2607], '55:': [2611], '3140-3148PubMed': [2612], 'shown).Figure': [2623], '2Anti-EGFR': [2624], 'Ku70/80.': [2637, 3633], '[35S]methionine': [2645, 3482, 4138], 'h': [2648, 3439, 3485, 3585, 4141], 'without': [2653, 2735, 2763, 2939, 2990, 3265, 3490, 4150, 4343, 4422], 'nm': [2655, 2663, 2670, 2677, 2737, 2765, 2773, 2941, 2992, 3269, 3277, 3311, 3492, 4155], '(lanes': [2657, 2767, 2776, 2788, 2793, 2956, 2960, 3271, 3280, 3294, 3299, 3322, 4145, 4151], '4)': [2667, 4148], '5)': [2674, 2770], '6)': [2681], 'before': [2685, 3512], 'harvesting.': [2687], 'analyzed': [2697, 2717, 3339, 3363, 3454, 3525, 4172], 'SDS-PAGE': [2699, 3456, 3527, 4174], 'autoradiography': [2701, 2719], '(upper': [2702, 2800, 2972, 3012, 3354, 3388, 3461, 4121], 'samples': [2709], 'anti-DNA': [2713], '(middle': [2720, 2806, 3465, 4125], 'panel)': [2721, 2801, 2807, 2812, 2973, 2977, 3013, 3019, 3462, 3466, 3470, 4122, 4126, 4130], 'Commassie': [2723], '(lower': [2726, 2811, 2976, 3018, 3375, 3469, 4129], 'panel).B,': [2727], 'anti-HER2': [2749], 'clone': [2751], 'N12': [2752], '(Neomarker).C,': [2753], '1–3)': [2789, 2957], '4–6)': [2794, 2961], 'blotted': [2796, 2969, 3008, 3396], 'same': [2815, 2981, 3022, 3474], 'blot.View': [2816, 3023], 'Large': [2817, 3024, 3530, 4274, 4495], 'Image': [2818, 3025, 3531, 4275], 'Figure': [2819, 3026, 3532, 4276], 'ViewerDownload': [2820, 3027, 3533, 4277], 'Hi-res': [2821, 3028, 3534, 4278], 'image': [2822, 3029, 3535, 4279], 'Download': [2823, 3030, 3536, 4280], '(PPT)mAb-induced': [2824], 'which': [2841, 3645], 'induced': [2843], 'murine': [2853], 'fibroblast': [2854], 'NIH': [2855], '3T3': [2856], 'engineered': [2858], 'express': [2860], '(HER14': [2863], 'cells;': [2864], '16Honegger': [2866], 'A.M.': [2867], 'Dull': [2868], 'T.J.': [2869], 'Felder': [2870], 'Obberghen': [2872], 'E.V.': [2873], 'Bellet': [2874], 'F.': [2875], 'Szapary': [2876], 'Schmidt': [2878], '199-209Abstract': [2886], '(311)': [2892], '(Fig.3': [2895], 'Data': [2901, 4071], 'HER14': [2918, 2933, 2984, 3450, 3572, 3594, 3621, 3627], 'mAb.Figure': [2931], '3A,': [2932], 'IgG': [2946, 2965, 4485, 4489], 'mouse': [2964, 4439], '7)': [2967], 'blot.': [2982, 3475], 'B,': [2983, 3377, 3412, 3928, 3945, 4132], 'min,': [2997, 3839], '(PPT)To': [3031, 3537], 'determine': [3032, 3953], 'functionally': [3037], 'active,': [3038], 'performed': [3041, 3548], 'assay': [3048], 'using': [3049, 3162, 3402, 3986, 4437, 4481], 'anti-Ku': [3052, 3090], 'immunoprecipitates.': [3053], 'positive': [3056], 'TGF-α-stimulated': [3063], 'A431': [3064, 3305], '2).': [3075], 'displayed': [3080], 'autophosphorylate': [3084], '(Fig.4': [3097, 3118, 3707], 'There': [3099, 3146], 'upon': [3109], 'status': [3111], 'assays': [3117], '3–5).': [3121], 'Subsequent': [3122], 'autoradiography,': [3124, 3392], 'phosphorylated': [3129, 3383], 'bands': [3131, 3385], 'confirmed': [3133, 3933], 'lysates,': [3161], 'GAL4-CTD': [3163], '(34Sun': [3164, 4202], 'S.C.': [3165, 4203], 'Maggirwar': [3166, 4204], 'S.B.': [3167, 4205], 'Harhaj': [3168, 4206], 'E.': [3169, 4000, 4207], '270:': [3174, 4212], '18347-18351Abstract': [3175, 4213], '(89)': [3183, 4221], '35Peterson': [3186], 'S.R.': [3187], 'Kurimasa': [3188], 'Oshimura': [3190], 'Dynan': [3192], 'W.S.': [3193], 'Bradbury': [3194], 'E.M.': [3195], 'Chen': [3196], 'D.J.': [3197], '92:': [3206], '3171-3174Crossref': [3207], '(267)': [3210], 'substrate': [3215, 3989], 'Taken': [3219], 'together,': [3220], 'leads': [3238], 'Ku70/80.Figure': [3246], '4Autophosphorylation': [3247], '8)': [3274], '7).': [3283], 'Two': [3284], 'sets': [3285], '3–5)': [3295], '6–8).': [3300], '15': [3314], 'and2).': [3324], 'After': [3325, 4432], 'immunoprecipitated,': [3326], 'set': [3328, 3358], 'assay,': [3338], 'SDS-PAGE,': [3341, 3365], 'transferred': [3342, 3366], 'nitrocellulose,': [3344, 3368], 'autoradiograph': [3346], '1-h': [3349], 'exposure': [3350], 'here': [3353], 'second': [3357], 'anti-phosphate-Tyr.': [3372], 'PY-20': [3374], 'confirm': [3379], 'A': [3387, 4498], 'panel),': [3389, 3870], 'subsequent': [3390], 'membrane': [3394], 'color': [3404, 4360], 'reaction': [3405], 'method': [3406], 'detection': [3408, 4492], '(as': [3409], 'associates': [3417], 'EGFRin': [3419], 'purified': [3425], 'U266': [3427, 3558, 3579], 'IP,': [3430], 'beads': [3433, 3598], 'incubated': [3436, 3582], 'nm)': [3449], 'Beads': [3452], 'Ku80': [3468, 3898, 4128], 'D,': [3476, 4237, 4348, 4418], 'wortmannin': [3501, 3687], '(Wort)': [3502], '(Sigma)': [3503], 'tyrphostin': [3505, 3693, 3711], 'A9': [3506, 3694, 3712], '(Tyroph)': [3507], '(Calbiochem)': [3508], 'preparing': [3513], 'lysates.': [3515], '25–4': [3523], 'autoradiography.View': [3529], 'study': [3539], 'mixing': [3549], 'isolation': [3552], 'leukemic': [3560], 'lack': [3563], 'then': [3566], 'incubation': [3567], 'washed': [3600], 'antibodies.': [3609], 'C': [3614, 4038], 'untreated': [3626], 'interacted': [3629], 'PI': [3643, 3670, 3684], '3-kinase,': [3644], 'downstream': [3648], 'target': [3649], 'Most,': [3653], 'if': [3654], 'all,': [3656], 'known': [3657], 'functions': [3658], 'examined': [3666], 'involvement': [3668], 'mediating': [3676], 'inhibitor': [3686, 3692], 'did': [3695], 'prevent': [3697], 'D).': [3708], 'reduced': [3713], 'and6.DNA-PK': [3727], 'primarily': [3733, 4044], 'localized': [3734, 3855, 3900, 4045], 'nucleus': [3737, 3858, 4321], '(21Jackson': [3738], 'finding': [3796], 'redistribution': [3809], 'mAbs.': [3816, 4131], 'subcellular': [3826, 4101], 'localization': [3827], 'cytosolic': [3841, 3903, 3922, 3975, 4088, 4106, 4180, 4241], 'extracts': [3844, 4109, 4164, 4187, 4242], 'prepared.': [3846], 'fraction': [3851, 3862, 3923, 4049, 4089], 'minor': [3861], 'cytosol': [3865, 3877], 'level': [3894], 'extracts.': [3906], 'Subcellular': [3907], 'fractionation': [3908], 'interacts': [3919], 'lane': [3929, 3947, 3950], '2)': [3930], 'decrease': [3935], 'compare': [3946], 'functional,': [3966], 'measured': [3968], 'fractions': [3978], '(36Lees-Miller': [3993], 'Sakaguchi': [3995], 'S.J.': [3998], 'Appela': [3999], 'Anderson': [4001], 'C.W.': [4002, 4015], '12:': [4007], '5041-5049Crossref': [4008], '(463)': [4011], '37Chan': [4014], '(247)': [4031], '75%': [4061], 'Fig.5': [4073], 'illustrate': [4075], 'function': [4092], 'concentration.Figure': [4095], '5Effect': [4096], 'distribution': [4102], '1and': [4152], 'Cytosolic': [4161], 'autoradiography.': [4176], '10μg': [4178], '(open': [4181, 4245], 'bars)': [4182, 4186, 4246, 4251], '(solid': [4185, 4250], 'assayed': [4196, 4255], 'described': [4201], 'expressed': [4226, 4261], 'percentage': [4229], '(100%)': [4233], 'each': [4235], 'increasing': [4238], 'count': [4265], 'per': [4266], 'minute': [4267], '(CPM)': [4268], 'incorporated': [4269], 'substrate.View': [4273], '(PPT)The': [4281], 'validated': [4294], 'confocal': [4296], 'microscopy': [4297], '(Fig.6).': [4298], '(shown': [4316, 4322, 4375], 'arrowheads)': [4318], 'arrowsthat': [4324], 'located': [4326], 'just': [4327], 'under': [4328], 'membrane)': [4331], '(panel': [4332], 'C).': [4333], 'stained': [4342], '6': [4347, 4354], 'red': [4349, 4365], 'staining).': [4350], 'Edemonstrate': [4355], 'development': [4357], 'yellow': [4359], 'co-localization': [4363, 4399], 'green(internalized': [4368], 'pixels': [4370], 'byarrowhead).': [4376], 'internalized': [4392], 'cells.Figure': [4397], '6Immunofluorescence': [4398], 'Cells': [4407], 'grown': [4409], 'coverslip': [4411], '(C,': [4417], 'E)': [4420], '(A': [4424], 'B)': [4426], 'fixed.': [4431], 'blocking,': [4433], 'double-stained': [4436], 'affinity-purified': [4438], '(A,': [4442], 'E,': [4445, 4456], 'bottom': [4448, 4459], 'panels),': [4449], 'rabbit': [4451], 'Ab': [4453], '(B': [4454], 'panels).': [4460], 'Control': [4461], 'pattern': [4462], 'Primary': [4473], '(DNA-PK': [4475], '225)': [4478], 'rhodamine': [4482], '(TRITC)-conjugated': [4483], 'goat-anti-mouse': [4484], 'fluorescein-conjugated': [4487], 'goat-anti-rabbit': [4488], 'arrowheads': [4496], 'andC': [4499], 'show': [4500]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1967494335', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 10}, {'year': 2014, 'cited_by_count': 12}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2025-01-12T05:47:44.904280', 'created_date': '2016-06-24'}
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