Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1967274635', 'doi': 'https://doi.org/10.1080/004982500433327', 'title': 'Identification of cytochrome P4503A as the major subfamily responsible for the metabolism of roquinimex in man', 'display_name': 'Identification of cytochrome P4503A as the major subfamily responsible for the metabolism of roquinimex in man', 'publication_year': 2000, 'publication_date': '2000-01-01', 'ids': {'openalex': 'https://openalex.org/W1967274635', 'doi': 'https://doi.org/10.1080/004982500433327', 'mag': '1967274635', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11055268'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/004982500433327', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S48760969', 'display_name': 'Xenobiotica', 'issn_l': '0049-8254', 'issn': ['0049-8254', '1366-5928'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5018042052', 'display_name': 'Helén Tuvesson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210130614', 'display_name': 'Active Biotech (Sweden)', 'ror': 'https://ror.org/03v3jkw12', 'country_code': 'SE', 'type': 'company', 'lineage': ['https://openalex.org/I4210130614']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'H. Tuvesson', 'raw_affiliation_strings': ['Pharmacokinetics and Metabolism, Active Biotech Research AB, PO Box 724, Lund, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Pharmacokinetics and Metabolism, Active Biotech Research AB, PO Box 724, Lund, Sweden', 'institution_ids': ['https://openalex.org/I4210130614']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057350210', 'display_name': 'Larry C. Wienkers', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'L. C. Wienkers', 'raw_affiliation_strings': ['Drug Metabolism Research, Pharmacia & Upjohn, Kalamazoo, MI, USA'], 'affiliations': [{'raw_affiliation_string': 'Drug Metabolism Research, Pharmacia & Upjohn, Kalamazoo, MI, USA', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113669805', 'display_name': 'Per Olov Gunnarsson', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I187531555', 'display_name': 'Lund University', 'ror': 'https://ror.org/012a77v79', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I187531555']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'P. O. Gunnarsson', 'raw_affiliation_strings': ['Department of Cell and Molecular Biology, Lund University, Solvegatan 21, SE-223 62 Lund, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell and Molecular Biology, Lund University, Solvegatan 21, SE-223 62 Lund, Sweden', 'institution_ids': ['https://openalex.org/I187531555']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111586642', 'display_name': 'Janeric Seidegård', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210130614', 'display_name': 'Active Biotech (Sweden)', 'ror': 'https://ror.org/03v3jkw12', 'country_code': 'SE', 'type': 'company', 'lineage': ['https://openalex.org/I4210130614']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'J. Seidegård', 'raw_affiliation_strings': ['Pharmacokinetics and Metabolism, Active Biotech Research AB, PO Box 724, Lund, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Pharmacokinetics and Metabolism, Active Biotech Research AB, PO Box 724, Lund, Sweden', 'institution_ids': ['https://openalex.org/I4210130614']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111796390', 'display_name': 'R. B. R. Persson', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'R. Persson', 'raw_affiliation_strings': ['Drug Metabolism Research, Pharmacia & Upjohn, Kalamazoo, MI, USA'], 'affiliations': [{'raw_affiliation_string': 'Drug Metabolism Research, Pharmacia & Upjohn, Kalamazoo, MI, USA', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.637, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 9, 'citation_normalized_percentile': {'value': 0.678032, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 78, 'max': 79}, 'biblio': {'volume': '30', 'issue': '9', 'first_page': '905', 'last_page': '914'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10375', 'display_name': 'Pharmacogenetics and Drug Metabolism', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10375', 'display_name': 'Pharmacogenetics and Drug Metabolism', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10570', 'display_name': 'Drug Transport and Resistance Mechanisms', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11036', 'display_name': 'Antibiotics Pharmacokinetics and Efficacy', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hydroxylation', 'display_name': 'Hydroxylation', 'score': 0.5220197}, {'id': 'https://openalex.org/keywords/unspecific-monooxygenase', 'display_name': 'Unspecific monooxygenase', 'score': 0.46994498}, {'id': 'https://openalex.org/keywords/cyp3a', 'display_name': 'CYP3A', 'score': 0.4441188}, {'id': 'https://openalex.org/keywords/microsoma', 'display_name': 'Microsoma', 'score': 0.4224916}], 'concepts': [{'id': 'https://openalex.org/C87644729', 'wikidata': 'https://www.wikidata.org/wiki/Q547502', 'display_name': 'Microsome', 'level': 3, 'score': 0.89759386}, {'id': 'https://openalex.org/C109650736', 'wikidata': 'https://www.wikidata.org/wiki/Q424440', 'display_name': 'CYP3A4', 'level': 4, 'score': 0.8690841}, {'id': 'https://openalex.org/C526171541', 'wikidata': 'https://www.wikidata.org/wiki/Q407693', 'display_name': 'Cytochrome P450', 'level': 3, 'score': 0.74496555}, {'id': 'https://openalex.org/C2777477808', 'wikidata': 'https://www.wikidata.org/wiki/Q407595', 'display_name': 'Metabolite', 'level': 2, 'score': 0.67326045}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.6297361}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5869231}, {'id': 'https://openalex.org/C119795356', 'wikidata': 'https://www.wikidata.org/wiki/Q407801', 'display_name': 'Isozyme', 'level': 3, 'score': 0.53789604}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.5340549}, {'id': 'https://openalex.org/C2781109383', 'wikidata': 'https://www.wikidata.org/wiki/Q898497', 'display_name': 'Hydroxylation', 'level': 3, 'score': 0.5220197}, {'id': 'https://openalex.org/C2780768313', 'wikidata': 'https://www.wikidata.org/wiki/Q408068', 'display_name': 'Cytochrome', 'level': 3, 'score': 0.49789572}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.49625713}, {'id': 'https://openalex.org/C2781064554', 'wikidata': 'https://www.wikidata.org/wiki/Q407883', 'display_name': 'Ketoconazole', 'level': 3, 'score': 0.49326414}, {'id': 'https://openalex.org/C2778307567', 'wikidata': 'https://www.wikidata.org/wiki/Q3860934', 'display_name': 'Unspecific monooxygenase', 'level': 5, 'score': 0.46994498}, {'id': 'https://openalex.org/C86745063', 'wikidata': 'https://www.wikidata.org/wiki/Q3737406', 'display_name': 'CYP1A2', 'level': 4, 'score': 0.4606912}, {'id': 'https://openalex.org/C89311334', 'wikidata': 'https://www.wikidata.org/wiki/Q1124842', 'display_name': 'Drug metabolism', 'level': 3, 'score': 0.4550068}, {'id': 'https://openalex.org/C11824378', 'wikidata': 'https://www.wikidata.org/wiki/Q5014970', 'display_name': 'CYP3A', 'level': 4, 'score': 0.4441188}, {'id': 'https://openalex.org/C2776524530', 'wikidata': 'https://www.wikidata.org/wiki/Q4119721', 'display_name': 'Microsoma', 'level': 4, 'score': 0.4224916}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3248427}, {'id': 'https://openalex.org/C2779548794', 'wikidata': 'https://www.wikidata.org/wiki/Q578726', 'display_name': 'Antifungal', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003577', 'descriptor_name': 'Cytochrome P-450 Enzyme System', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006912', 'descriptor_name': 'Hydroxyquinolines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008862', 'descriptor_name': 'Microsomes, Liver', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D006899', 'descriptor_name': 'Mixed Function Oxygenases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000906', 'descriptor_name': 'Antibodies', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000906', 'descriptor_name': 'Antibodies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051544', 'descriptor_name': 'Cytochrome P-450 CYP3A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D065607', 'descriptor_name': 'Cytochrome P-450 Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003577', 'descriptor_name': 'Cytochrome P-450 Enzyme System', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D003577', 'descriptor_name': 'Cytochrome P-450 Enzyme System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018076', 'descriptor_name': 'DNA, Complementary', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018076', 'descriptor_name': 'DNA, Complementary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004791', 'descriptor_name': 'Enzyme Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006900', 'descriptor_name': 'Hydroxylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006912', 'descriptor_name': 'Hydroxyquinolines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007654', 'descriptor_name': 'Ketoconazole', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007654', 'descriptor_name': 'Ketoconazole', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008862', 'descriptor_name': 'Microsomes, Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006899', 'descriptor_name': 'Mixed Function Oxygenases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006899', 'descriptor_name': 'Mixed Function Oxygenases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006899', 'descriptor_name': 'Mixed Function Oxygenases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D013739', 'descriptor_name': 'Testosterone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013739', 'descriptor_name': 'Testosterone', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014217', 'descriptor_name': 'Troleandomycin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014217', 'descriptor_name': 'Troleandomycin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1080/004982500433327', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S48760969', 'display_name': 'Xenobiotica', 'issn_l': '0049-8254', 'issn': ['0049-8254', '1366-5928'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11055268', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 15, 'referenced_works': ['https://openalex.org/W2006998778', 'https://openalex.org/W2020650620', 'https://openalex.org/W2027569623', 'https://openalex.org/W2053481602', 'https://openalex.org/W2060317640', 'https://openalex.org/W2115717824', 'https://openalex.org/W2131614625', 'https://openalex.org/W2155268095', 'https://openalex.org/W2169290209', 'https://openalex.org/W2254238718', 'https://openalex.org/W2304131176', 'https://openalex.org/W2345215322', 'https://openalex.org/W2410779580', 'https://openalex.org/W2525183727', 'https://openalex.org/W4244098017'], 'related_works': ['https://openalex.org/W2166929201', 'https://openalex.org/W2150438415', 'https://openalex.org/W2116139281', 'https://openalex.org/W2077331899', 'https://openalex.org/W2030064604', 'https://openalex.org/W2006537063', 'https://openalex.org/W1967274635', 'https://openalex.org/W1811726278', 'https://openalex.org/W1777842366', 'https://openalex.org/W1764267039'], 'abstract_inverted_index': {'1.': [0], 'Roquinimex,': [1], 'a': [2, 96, 132, 156], 'novel': [3], 'immunomodulator,': [4], 'is': [5, 32], 'metabolized': [6], 'in': [7, 39, 63, 161, 168], 'liver': [8, 65, 99, 148, 170], 'microsomes': [9, 100], 'from': [10, 101, 138], 'mouse': [11], 'and': [12, 20, 52, 89, 119], 'rat': [13], 'via': [14], 'cytochrome': [15, 29], 'P450s': [16], 'to': [17], 'four': [18], 'hydroxylated': [19], 'two': [21], 'demethylated': [22], 'metabolites': [23, 62, 167], '(R1−6).': [24], 'The': [25, 67], 'study': [26], 'investigated': [27], 'which': [28], 'P450': [30], 'enzyme(s)': [31], 'responsible': [33], 'for': [34, 59, 71, 159], 'the': [35, 60, 72, 84, 162], 'metabolism': [36, 114], 'of': [37, 69, 87, 91, 98, 111, 123, 164], 'roquinimex': [38, 112, 139, 165], 'man.': [40], '2.': [41], 'Enzyme': [42], 'kinetic': [43], 'analysis': [44], 'demonstrated': [45, 116], 'an': [46], 'apparent': [47], 'Km': [48], '=': [49, 54, 105], '1.28-7.00': [50], 'mm': [51], 'Vmax': [53], '50-159': [55], 'pmol·mg−1': [56], 'microsomal': [57, 78], 'protein·min−1': [58], 'primary': [61, 73, 113, 166], 'human': [64, 147, 169], 'microsomes.': [66, 149, 171], 'sum': [68], 'Clint': [70], 'pathways': [74], 'was': [75, 93, 115, 136], '0.167': [76], 'μl·mg−1': [77], 'protein·min−1.': [79], '3.': [80], 'A': [81], 'correlation': [82], 'between': [83], 'formation': [85, 163], 'rate': [86], 'R1-6': [88], '6β-hydroxylation': [90], 'testosterone': [92], 'obtained': [94], 'within': [95], 'panel': [97], '11': [102], 'individuals': [103], '(r2': [104], '0.72-0.97).': [106], 'Furthermore,': [107], 'significant': [108], 'inhibition': [109], '(<90%)': [110], 'by': [117, 140, 146], 'ketoconazole': [118], 'troleandomycin,': [120], 'specific': [121], 'inhibitors': [122], 'CYP3A4': [124, 144, 160], 'as': [125, 127, 145], 'well': [126], 'with': [128, 142], 'anti-CYP3A4': [129], 'antibodies.': [130], 'Moreover,': [131], 'similar': [133], 'metabolite': [134], 'pattern': [135], 'produced': [137], 'incubation': [141], 'cDNA-expressed': [143], '4.': [150], 'In': [151], 'conclusion,': [152], 'these': [153], 'data': [154], 'indicate': [155], 'major': [157], 'role': [158]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1967274635', 'counts_by_year': [{'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 1}], 'updated_date': '2024-12-14T08:09:39.957726', 'created_date': '2016-06-24'}