Title: The effect of tobacco exposure on maternal and fetal thyroid function
Abstract: To determine the effect of smoking on maternal and fetal thyroid function.This prospective cohort study involved healthy women undergoing elective cesarean section for term singleton infants. Maternal and fetal thyroid indices were compared between smokers (n=21) and non-smokers (n=83).Maternal thyrotropin (TSH) concentrations were significantly lower in smokers than non-smokers (1.75 mIU/L versus 2.15 mIU/L, respectively, p=0.007), with similar free thyroxine (FT4) concentrations (9.59 pmol/L versus 9.56 pmol/L, p=0.755). For women who smoked, the correlation between the average number of cigarettes smoked per day and maternal TSH concentrations was -0.427, p=0.054. Infants of smokers and non-smokers had similar umbilical TSH (5.43 mIU/L versus 5.82 mIU/L, p=0.124) and FT4 concentrations (13.06 pmol/L versus 13.57 pmol/L, p=0.049).We demonstrated for the first time that women who smoke during pregnancy have significantly lower TSH concentrations than non-smokers.
Publication Year: 2008
Publication Date: 2008-04-21
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 28
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