Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1967085442', 'doi': 'https://doi.org/10.3109/07435807509053853', 'title': 'Isolation and Culture of FSH Responsive Sertoli Cells', 'display_name': 'Isolation and Culture of FSH Responsive Sertoli Cells', 'publication_year': 1975, 'publication_date': '1975-01-01', 'ids': {'openalex': 'https://openalex.org/W1967085442', 'doi': 'https://doi.org/10.3109/07435807509053853', 'mag': '1967085442', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/170059'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.3109/07435807509053853', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210224558', 'display_name': 'Endocrine Research Communications', 'issn_l': '0093-6391', 'issn': ['0093-6391'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310315681', 'host_organization_name': 'Marcel Dekker', 'host_organization_lineage': ['https://openalex.org/P4310315681'], 'host_organization_lineage_names': ['Marcel Dekker'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5051466855', 'display_name': 'Anna Steinberger', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I86519309', 'display_name': 'The University of Texas at Austin', 'ror': 'https://ror.org/00hj54h04', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86519309']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'A. Steinberger', 'raw_affiliation_strings': ['Program in Reproductive Biology and Endocrinology Program in Pharmacology, The University of Texas Medical School at Houston, Houston, Texas, 77025'], 'affiliations': [{'raw_affiliation_string': 'Program in Reproductive Biology and Endocrinology Program in Pharmacology, The University of Texas Medical School at Houston, Houston, Texas, 77025', 'institution_ids': ['https://openalex.org/I86519309']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024045216', 'display_name': 'Jerrold J. Heindel', 'orcid': 'https://orcid.org/0000-0002-0719-6523'}, 'institutions': [{'id': 'https://openalex.org/I86519309', 'display_name': 'The University of Texas at Austin', 'ror': 'https://ror.org/00hj54h04', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86519309']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J. J. Heindel', 'raw_affiliation_strings': ['Program in Reproductive Biology and Endocrinology Program in Pharmacology, The University of Texas Medical School at Houston, Houston, Texas, 77025'], 'affiliations': [{'raw_affiliation_string': 'Program in Reproductive Biology and Endocrinology Program in Pharmacology, The University of Texas Medical School at Houston, Houston, Texas, 77025', 'institution_ids': ['https://openalex.org/I86519309']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113936096', 'display_name': 'JK Lindsey', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I86519309', 'display_name': 'The University of Texas at Austin', 'ror': 'https://ror.org/00hj54h04', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86519309']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J. N. Lindsey', 'raw_affiliation_strings': ['Program in Reproductive Biology and Endocrinology Program in Pharmacology, The University of Texas Medical School at Houston, Houston, Texas, 77025'], 'affiliations': [{'raw_affiliation_string': 'Program in Reproductive Biology and Endocrinology Program in Pharmacology, The University of Texas Medical School at Houston, Houston, Texas, 77025', 'institution_ids': ['https://openalex.org/I86519309']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012414677', 'display_name': 'JSH Elkington', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I86519309', 'display_name': 'The University of Texas at Austin', 'ror': 'https://ror.org/00hj54h04', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86519309']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J. S. H. Elkington', 'raw_affiliation_strings': ['Program in Reproductive Biology and Endocrinology Program in Pharmacology, The University of Texas Medical School at Houston, Houston, Texas, 77025'], 'affiliations': [{'raw_affiliation_string': 'Program in Reproductive Biology and Endocrinology Program in Pharmacology, The University of Texas Medical School at Houston, Houston, Texas, 77025', 'institution_ids': ['https://openalex.org/I86519309']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071126400', 'display_name': 'Barbara M. Sanborn', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I86519309', 'display_name': 'The University of Texas at Austin', 'ror': 'https://ror.org/00hj54h04', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I86519309']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'B. M. Sanborn', 'raw_affiliation_strings': ['Program in Reproductive Biology and Endocrinology Program in Pharmacology, The University of Texas Medical School at Houston, Houston, Texas, 77025'], 'affiliations': [{'raw_affiliation_string': 'Program in Reproductive Biology and Endocrinology Program in Pharmacology, The University of Texas Medical School at Houston, Houston, Texas, 77025', 'institution_ids': ['https://openalex.org/I86519309']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111731122', 'display_name': 'E. Steinberger', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I55302922', 'display_name': 'The University of Texas Medical Branch at Galveston', 'ror': 'https://ror.org/016tfm930', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I55302922']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'E. Steinberger', 'raw_affiliation_strings': ['Department of Human Biological Chemistry and Genetics, The University of Texas Medical Branch, Galveston, Texas, 77550'], 'affiliations': [{'raw_affiliation_string': 'Department of Human Biological Chemistry and Genetics, The University of Texas Medical Branch, Galveston, Texas, 77550', 'institution_ids': ['https://openalex.org/I55302922']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 22.085, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 208, 'citation_normalized_percentile': {'value': 0.985133, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '2', 'issue': '3', 'first_page': '261', 'last_page': '272'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10364', 'display_name': 'Reproductive Biology and Fertility', 'score': 0.9933, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10364', 'display_name': 'Reproductive Biology and Fertility', 'score': 0.9933, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12929', 'display_name': 'Animal Genetics and Reproduction', 'score': 0.9839, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10116', 'display_name': 'Sperm and Testicular Function', 'score': 0.9813, 'subfield': {'id': 'https://openalex.org/subfields/2743', 'display_name': 'Reproductive Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/isolation', 'display_name': 'Isolation', 'score': 0.7437308}], 'concepts': [{'id': 'https://openalex.org/C2781068068', 'wikidata': 'https://www.wikidata.org/wiki/Q195614', 'display_name': 'Sertoli cell', 'level': 3, 'score': 0.8205161}, {'id': 'https://openalex.org/C2775941552', 'wikidata': 'https://www.wikidata.org/wiki/Q25212305', 'display_name': 'Isolation (microbiology)', 'level': 2, 'score': 0.7437308}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.386072}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.37218338}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.2240178}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.18367952}, {'id': 'https://openalex.org/C123765429', 'wikidata': 'https://www.wikidata.org/wiki/Q36961', 'display_name': 'Spermatogenesis', 'level': 2, 'score': 0.16489273}], 'mesh': [{'descriptor_ui': 'D005640', 'descriptor_name': 'Follicle Stimulating Hormone', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011956', 'descriptor_name': 'Receptors, Cell Surface', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D012708', 'descriptor_name': 'Sertoli Cells', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002469', 'descriptor_name': 'Cell Separation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000242', 'descriptor_name': 'Cyclic AMP', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000242', 'descriptor_name': 'Cyclic AMP', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005640', 'descriptor_name': 'Follicle Stimulating Hormone', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005640', 'descriptor_name': 'Follicle Stimulating Hormone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008274', 'descriptor_name': 'Magnesium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008854', 'descriptor_name': 'Microscopy, Electron', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012708', 'descriptor_name': 'Sertoli Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D012708', 'descriptor_name': 'Sertoli Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012708', 'descriptor_name': 'Sertoli Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.3109/07435807509053853', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210224558', 'display_name': 'Endocrine Research Communications', 'issn_l': '0093-6391', 'issn': ['0093-6391'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/P4310315681', 'host_organization_name': 'Marcel Dekker', 'host_organization_lineage': ['https://openalex.org/P4310315681'], 'host_organization_lineage_names': ['Marcel Dekker'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/170059', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 19, 'referenced_works': ['https://openalex.org/W1563179743', 'https://openalex.org/W1590572014', 'https://openalex.org/W174948978', 'https://openalex.org/W1775749144', 'https://openalex.org/W1788268544', 'https://openalex.org/W1996512434', 'https://openalex.org/W2006178968', 'https://openalex.org/W2044809388', 'https://openalex.org/W2061467103', 'https://openalex.org/W2072740613', 'https://openalex.org/W2076384435', 'https://openalex.org/W2103831035', 'https://openalex.org/W2126210675', 'https://openalex.org/W2148778737', 'https://openalex.org/W2317101672', 'https://openalex.org/W2343182587', 'https://openalex.org/W252780066', 'https://openalex.org/W36040512', 'https://openalex.org/W623777235'], 'related_works': ['https://openalex.org/W2788277189', 'https://openalex.org/W2393236173', 'https://openalex.org/W2130076355', 'https://openalex.org/W2119695867', 'https://openalex.org/W2082860237', 'https://openalex.org/W2046158694', 'https://openalex.org/W2013243191', 'https://openalex.org/W1993764875', 'https://openalex.org/W1990804418', 'https://openalex.org/W1971568933'], 'abstract_inverted_index': {'Methods': [0], 'for': [1, 66, 131, 147], 'the': [2, 22, 104, 123, 135, 148, 157], 'isolation': [3], 'and': [4, 30, 48, 80, 98], 'culture': [5, 65, 138], 'of': [6, 9, 21, 72, 85, 95, 150, 153], 'enriched': [7], 'populations': [8], 'Sertoli': [10, 23, 35, 61, 115, 124, 158], 'cells': [11, 24, 36, 87, 109, 125], 'from': [12], '20-60': [13], 'day': [14], 'old': [15], 'rats': [16], 'are': [17], 'described.': [18], 'The': [19, 137], 'identity': [20], 'was': [25], 'verified': [26], 'by': [27], 'bright': [28], 'light': [29], 'electron': [31], 'microscopy.': [32], 'Freshly': [33], 'isolated': [34, 106], 'specifically': [37], 'bound': [38], 'follicle': [39], 'stimulating': [40], 'hormone': [41, 46], '(FSH)': [42], 'but': [43, 74], 'not': [44], 'luteinizing': [45], '(LH)': [47], 'responded': [49], 'to': [50], 'FSH': [51, 81, 89, 132], 'stimulation': [52, 94], 'with': [53, 88], 'dramatic': [54], 'increase': [55], 'in': [56, 64, 91, 134, 144], 'cyclic': [57, 96], 'AMP': [58, 97], 'level.': [59], 'Isolated': [60], 'cells,': [62, 116], 'maintained': [63], '11': [67], 'days,': [68], 'showed': [69], 'no': [70], 'evidence': [71, 121], 'proliferation': [73], 'retained': [75], 'their': [76], 'characteristic': [77], 'ultrastructural': [78], 'features': [79], 'binding': [82, 100], 'ability.': [83], 'Incubation': [84], 'cultured': [86, 108], 'resulted': [90], 'a': [92, 127, 142], 'significant': [93], 'androgen': [99], 'protein': [101], '(ABP).': [102], 'Since': [103], 'freshly': [105], 'or': [107], 'were': [110], 'predominantly': [111], '(greater': [112], 'than': [113], '80%)': [114], 'these': [117], 'results': [118], 'provide': [119], 'direct': [120], 'that': [122], 'represent': [126], 'primary': [128], 'target': [129], 'site': [130], 'activity': [133], 'testes.': [136], 'method': [139], 'also': [140], 'provides': [141], 'valuable': [143], 'vitro': [145], 'model': [146], 'study': [149], 'chronic': [151], 'effects': [152], 'various': [154], 'agents': [155], 'on': [156], 'cell.': [159]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1967085442', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 2}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-14T08:10:45.306223', 'created_date': '2016-06-24'}