Title: Application of the phosphoramidite-phosphite triester approach for the synthesis of combinations between oxygenated sterols and nucleoside analogues linked by phosphodiester bonds
Abstract: The recently developed phosphoramidite-phosphite triester approach applied in solid phase DNA synthesis seems to be the technique of choice for the preparation of labile multifunctional compounds linked by phosphodiester bonds in solution. Thus, to make the lipophilic oxysterols water-soluble for biological studies, we have prepared several combinations between polyoxygenated sterols and nucleoside analogues using Cβ-cyanoethoxy)bis(diisopropylamine) phosphine 2 as phosphorylating agent. This approach afforded the desired compounds of type 1 under very mild conditions and in reasonably high yields (> 60%).
Publication Year: 1990
Publication Date: 1990-01-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 18
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