Title: Metabolism of endogenous lipid by the perfused rat kidney
Abstract: It has been demonstrated that in vivo, exogenous [14C] palmitate is rapidly taken up and incorporated into phospholipid, neutral lipid and free fatty acid fractions of the kidney. During subsequent perfusion in an in vitro system, the amount of isotope decreases most rapidly in the neutral lipid (triglyceride) fraction. Net loss of chemical fatty acids cannot be detected after 2 hr. perfusion. The primary source of 14CO2 produced appears to be fatty acids from either neutral lipid or phospholipids. Since loss of 14C from neutral lipids is independent of O2 and substrates, regulation of fatty acid oxidation must be beyond triglyceride lipase.
Publication Year: 1978
Publication Date: 1978-03-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 3
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