Sensitive detection of transitional cell carcinoma of the bladder by microsatellite analysis of cells exfoliated in urine

Name: Work Video:
Duration: 3 min 30 s
Davide Seripa; Paola Parrella; Michele Gallucci; Carolina Gravina; Sara Papa; Pasquale Fortunato; Antonio Alcini; Gerardo Flammia; Marzia Lazzari; Vito Michele Fazio
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2005, 2027, 2253, 4042], 'expression': [460, 508, 914, 964, 1744, 2198, 2254, 2713, 2731, 2744, 2962, 3111, 3131, 3160, 3169, 3300, 3534, 3894, 3929], 'p53,': [462, 701, 1330, 1452, 2200, 2379], 'bcl-2': [463, 490, 507, 848, 858, 870, 910, 941, 1567, 1718, 2258, 2288, 2316, 2453, 2873, 2898, 2915, 2935, 2952, 2964, 2987, 3026, 3053, 3138, 3162, 3168, 3187, 3298, 3890, 4113], 'PCNA': [465, 501, 522, 954, 989, 1704, 2203, 2336, 2366, 2382, 2712, 2730, 2743, 3110], 'determined': [467], 'immunohistochemistry': [469], 'immunoblotting': [471, 1339, 2597, 2809], '(p53),': [472], 'viable': [474, 991, 1321, 1360, 1417, 1432, 2707, 3105], 'growth': [476, 498, 519, 993, 1323, 1346, 1425, 2129, 2138, 2167, 2182, 2709, 2727, 2740, 3107], 'rate': [477, 499, 520, 994, 1347, 1426, 2130, 2139, 2710, 2728, 2741, 3108], 'was': [478, 744, 756, 1083, 1113, 1123, 1145, 1275, 1353, 1427, 1737, 1745, 1826, 1837, 1859, 1882, 1891, 1916, 1947, 1982, 2008, 2031, 2120, 2151, 2212, 2289, 2337, 2469, 2527, 3199, 3325], 'determined.': [479], 'Hypoxia': [480, 560, 3308, 3427, 4074], 'induced': [484, 2827, 3059, 3291, 3600, 3852], 'significant': [485, 494, 2234, 2530, 3050], 'up-regulation': [486, 3926], 'p53': [488, 505, 537, 541, 730, 772, 787, 805, 814, 822, 834, 868, 902, 939, 1702, 1757, 1887, 2030, 2046, 2211, 2238, 2256, 2460, 2468, 2495, 2511, 2551, 2573, 2595, 2614, 2793, 2831, 2844, 2862, 2924, 2946, 2976, 2998, 3039, 3078, 3135, 3152, 3276, 3296, 3498, 3666, 3702, 3732, 3885, 3931, 4078, 4091], 'expression,': [491], 'accompanied': [492], 'decreases': [495], 'expression.': [502, 523, 2977], 'Up-regulation': [503], 'persisted': [509, 2847], 'both': [511, 2153, 2725, 2804, 3103, 3295, 3317, 3328, 3340], 'despite': [516, 534, 2861, 2974, 3077], 'increased': [517, 614, 2792, 2875, 2900, 2969, 3102, 3170], 'Cells': [524], 'escaping': [525], 'acquired': [527], 'sustained': [528], 'apoptosis': [531, 631, 808, 872, 2928, 2949, 2991, 3058, 3318, 3492, 3704, 3809, 4144], 'proliferate': [533, 2782], 'an': [535, 751, 765, 931, 969, 1128, 1404, 2042, 2699, 2828, 3083, 3292, 3302, 3780], 'elevated': [536, 3140], 'level,': [538], 'suggesting': [539], 'transfer': [542, 1869, 3274, 3836], 'tumor': [546, 773, 2665, 3208, 3280, 3363, 3437, 3466], 'should': [547], 'reevaluated': [549], 'as': [550, 968, 1085, 1236, 1264, 1697, 1713, 1730, 2038, 2091, 2801, 3810], 'gene': [553, 775, 779, 793, 3268, 3754, 3835, 3893], 'therapy': [554, 3240, 3269], 'approach.': [555], '©': [556], '2001': [557], 'Wiley-Liss,': [558], 'Inc.': [559], 'are': [563, 576, 652, 661, 703, 2089, 2192, 2277, 2603, 3213], 'pathophysiological': [565], 'occur': [568], 'during': [569, 2714, 2732, 2761, 2784, 2796, 2848, 2865, 2876, 2904, 3072, 3112, 3141, 3171, 3465], 'injury,': [570], 'ischemia-reperfusion,': [571], 'stroke.': [573], 'Hypoxic': [574, 1021, 1081], 'regions': [575], 'often': [577], 'found': [578, 1738, 3326], 'tumors,': [581], 'especially': [582], 'center': [585], 'rapidly': [587], 'growing': [588, 1079], 'cancers': [589, 860, 3087], 'or': [590, 926, 947, 1703, 2500, 3091, 3264], 'those': [591, 2224, 2302, 2345, 3255], 'injured': [592], 'embolization': [594, 2666], 'Tumors': [596], 'not': [598, 823, 879, 2877, 2966, 2996, 3013, 3029, 3133, 3223, 3933], 'only': [599, 880, 2878, 3134], 'survive': [600], 'these': [601, 720, 2243, 2533, 3286], 'circumstances': [603, 2688], 'but': [604, 886, 2767, 2883, 2968, 2995, 3136, 3932, 4080], 'also': [605, 662, 887, 979, 1883, 2290, 2566, 2884, 2979, 3137, 3165], 'expand': [606], 'subsequently': [607], 'seem': [611], 'metastasis': [617], 'tolerance': [619], 'therapy.1-3': [622], 'Recent': [623], 'investigations': [624], 'suggested': [626, 921, 3205], 'might': [629, 2947, 3012, 3028, 3055, 3066, 3180, 3244, 3259, 3281], 'induce': [630, 807, 904, 2927, 2948], 'cells,': [634, 2641, 2698, 2771, 2994], 'including': [635, 2642], 'lines.4-8': [639], 'Mechanisms': [640, 3001], 'which': [642, 3038, 3186], 'regrow': [645, 3071], 'insult,': [650], 'however,': [651, 2231, 2362, 2671, 2722, 3048], 'still': [653, 3150], 'unclear.': [654], 'Effects': [655], 'hypoxic-injured': [659], 'yet': [663], 'elucidated.': [666], 'Therefore,': [667, 2749, 3062], 'we': [668], 'effects': [671], 'line,': [685, 1028, 2704, 3306], 'focusing': [686], 'apoptosis-related': [688], 'oncogenes.': [689], 'Although': [690, 2147, 2920], 'many': [691], 'lines': [694, 724, 3638], 'due': [698, 825], 'mutating': [700, 813], 'there': [702, 2526], 'few': [704, 1071], 'lines.': [708], 'The': [709, 771, 833, 846, 1087, 1157, 1348, 1416, 1489, 1513, 1835, 1889, 2061, 2131, 2204, 2281, 2329, 2462, 2562, 2719, 3177, 3663], 'HCT': [715, 1023, 2052], '116': [716, 2053], 'one': [718, 836, 2657], 'has': [726, 919, 965, 980, 3231], 'wild': [728, 2944], 'type': [729, 901, 2945], 'when': [731, 3088, 3197], '(95%': [736], 'air': [737, 1133, 2003], 'atmosphere,': [738], 'CO2,': [740], 'at': [741, 1051, 1153, 1383, 1527, 1549, 1556, 1570, 1582, 1613, 1653, 1690, 1809, 1839, 1909, 1923, 1933, 1971, 1991], '37°C.9': [742], 'HCT116': [743, 2700], 'present': [748, 937, 1005, 2838, 2960], 'study,': [749, 938, 2696, 2839, 2961, 3099], 'because': [750], 'necessary': [757], 'whether': [760], 'could': [763, 806, 2989, 3007], 'suppresser': [774], 'crucial': [778], 'regulate': [781], 'pathways.': [783, 3942], 'High': [784], 'levels': [785], 'can': [788, 2676, 3237], 'include': [789], 'transcription': [791], 'products': [794, 2553], 'involved': [795], 'cycle': [799], 'arrest': [800], 'pathway.10': [803], 'Wild-type': [804, 3701], 'cells,11': [811], 'whereas,': [812], 'renders': [815], 'resistant': [818], 'apoptosis.': [820, 2940], 'If': [821, 3234], 'work': [824, 3008, 3014], 'mutation,': [827], 'lose': [830], 'potential.': [832, 3252, 3346], 'most': [839, 2660], 'commonly': [840], 'mutated': [841], 'genes': [842], 'clinical': [844, 3232], 'cancers.12': [845], 'proto-oncogene': [847], 'well': [850], 'known': [851], 'prevent': [853, 2939, 2997, 3056], 'apoptosis.13,': [854], 'Overexpression': [856], 'protects': [859], 'from': [861, 1429, 1855], 'apoptosis.15,': [862], '16': [863, 3829], 'Thus': [864], 'roles': [866], 'highlight': [873], 'importance': [875], 'death,': [878], 'development': [883], 'cancer,': [885], 'response': [890], 'chemotherapeutic': [895, 3857], 'agents': [896], 'damage': [898, 3634], 'DNA.': [899], 'Wild': [900], 'death': [907, 927, 3848, 4019, 4111], 'down-regulating': [909, 2951], 'up-regulating': [912], 'bax': [913, 3892, 3928], 'growth,': [917], 'been': [920, 966, 981, 2757], 'determine': [923], 'survival': [925, 3758], 'stimulus.17,': [933], '18': [934, 3909], 'evaluate': [945, 984, 1008], 'closely': [956], 'related': [957], 'cycle,': [961], 'its': [963, 2035], 'used': [967, 982, 1354, 1725], 'index': [970], 'proliferation.19,': [973], '20': [974, 3976], 'Trypan': [975], 'blue': [976, 998, 1350, 1410], 'dye': [977, 999], 'staining': [978, 1000, 1326, 1699, 1715, 1735, 1750, 2208, 2285, 2333, 2377, 2395, 2450], 'cellular': [985], 'viability.7,': [986], '8,': [987], '21': [988, 4002], 'obtained': [995, 1428, 1854, 2775, 3182], 'trypan': [997, 1349, 1409], 'proliferative': [1009], 'MATERIAL': [1015], 'AND': [1016], 'METHODS': [1017], 'Cell': [1018, 3470, 3511, 4094], 'Culture': [1019], 'Exposure': [1022], '116,': [1024], 'maintained': [1030, 3194, 3344], "McCoy's": [1032], '5A': [1033], 'medium': [1034], '10%': [1036, 1862], 'fetal': [1037], 'bovine': [1038], 'serum,': [1039], '2': [1040, 1583, 3385], 'mM': [1041], 'L-glutamine,': [1042], '50': [1044], 'μg/ml': [1045], 'gentamicin.': [1046], 'Single-cell': [1047], 'suspensions': [1048], 'plated': [1050, 1089], 'density': [1053, 2007, 2463, 2493], '5': [1055, 1381, 1414, 1509, 1535, 1842, 1941, 3480], '×': [1056], '105': [1057], 'cells/mm2': [1058], 'culture': [1061, 1092], 'dish,': [1062], 'allowed': [1064], 'reach': [1066], '30–40%': [1067], 'confluence': [1068], 'days.': [1072], 'All': [1073, 2087, 2101], 'experiments': [1074], 'performed': [1076, 1084, 1124, 2065], 'exponentially': [1078], 'exposure': [1082, 3602], 'follows.': [1086], 'dish': [1093, 1369], 'placed': [1095], 'into': [1096, 1115, 1162], 'specially': [1098], 'designed': [1099], 'chamber': [1101, 1117, 1144, 1274], 'sealed': [1102], 'rubber': [1104], 'stoppers.': [1105], 'Gas': [1106], 'containing': [1107, 1131], 'insufflated': [1114], '1': [1119, 1139, 1180, 1206, 1557, 1931, 1969, 3348], 'hr.': [1120, 1140], 'Sham': [1121], 'treatment': [1122, 1379, 2051], 'insufflation': [1126, 1174, 1199], 'aerobic': [1129, 1177, 1187, 1286, 1294, 2955, 3010], 'gas': [1130, 1178, 1204, 1283], 'atmosphere': [1134], 'After': [1141, 1268, 1362, 1386, 1460, 1530, 1589, 1616, 1656, 1676, 1759, 1793, 1936, 1974], 'insufflation,': [1142], 'clamped': [1146], 'set': [1148], 'incubator': [1152], '37°C.': [1154], 'Experimental': [1155], 'design': [1156], 'divided': [1161], 'following': [1164, 1318, 1543, 3535], 'four': [1165], 'groups:': [1166], '1)': [1167], 'sham': [1168, 2142, 2227, 2305, 2348, 2400, 2414, 2433, 2478, 2502, 2523, 2556, 2617], 'group': [1169, 1194, 1224, 1252, 2133, 2143, 2157, 2161, 2172, 2311, 2323, 2343, 2349, 2357, 2373, 2474, 2484, 2488, 2499, 2503, 2519, 2540, 2544, 2557, 2565, 2579], '(n': [1170, 1195, 1225, 1253, 2056], '=': [1171, 1196, 1226, 1254, 2057], '8),': [1172], 'hr,': [1181, 1207], 'incubated': [1185, 1211, 1292, 1516, 1540, 1596, 1623, 1663, 1917, 1948, 1983], 'condition': [1188, 1214, 1295, 1314, 2973, 3192], '2)': [1192], '10),': [1197], 'N2/5%': [1202, 1281], '(initial': [1218], 'incubation);': [1220], '3)': [1221], '5),': [1227], 'treated': [1231, 1259], 'same': [1234, 1262, 1306, 1313, 1978], 'way': [1235, 1263], 'group,': [1239, 2361, 2524, 2618, 2621, 2625], 'incubation': [1244, 1438, 1444, 2765, 2826, 2882, 2889, 2897, 3022, 3114, 3173], '4)': [1250], 'reoxygenatic': [1251, 2160, 2221, 2299, 2360, 2410, 2424, 2443, 2487, 2543, 2628, 3113, 3143, 3172, 3332], '6),': [1255], 'group.': [1267, 2228, 2306, 2479, 2629], 'initial': [1270, 2716, 2763, 2798, 2880, 2906, 3020], 'incubation,': [1272, 1364, 1461, 1760, 2800, 2931, 3047, 3076], 'opened': [1276], 'replace': [1278], 'gas.': [1287], 'Subsequently,': [1288, 1844, 1913], '(reoxygenatic': [1300], 'incubation).': [1301], 'each': [1303, 1363, 1446, 1856], 'experiment': [1304], 'five': [1307], 'dishes': [1308, 1463, 1475, 1538], 'simultaneously': [1315, 2933], 'respective': [1319], 'determinations:': [1320], 'rate,': [1324], 'immunohistochemical': [1325, 2268, 2806], 'proteins': [1328, 1450, 2397], 'bcl-2,': [1331, 1453, 2201, 2380], 'proliferating': [1333, 1455, 2261, 2428], 'nuclear': [1335, 1457, 2263, 2430, 3507], 'antigen': [1336, 1458, 2264, 2431], '(PCNA),': [1337], 'protein': [1341, 1758, 1820, 1848, 1857, 2047, 2197, 2383, 2461, 2465, 2491, 2508, 2552, 2574, 2592, 2794, 2832, 2845, 2863, 2874, 2899, 2925, 2936, 2988, 2999, 3027, 3040, 3054, 3079, 3130, 3153, 3188, 3299, 3508, 3667, 3989], 'p53.': [1343, 3641], 'Viable': [1344, 1423, 2127, 2180, 2738], 'dye-staining': [1351], 'procedure': [1352], 'estimate': [1356], 'ratio': [1358, 2040], 'washed': [1371, 1465, 1505, 1764], 'phosphate-buffered': [1373], 'saline': [1374], '(PBS)': [1375], 'trypsin': [1378], 'minutes': [1382, 1503, 1510, 1526], 'room': [1384, 1528, 1550, 1614, 1654, 1810, 1934, 1972, 1992], 'temperature.': [1385, 1529, 1615, 1655, 1935, 1973], 'centrifugation': [1387, 1814], 'remove': [1389, 1770], 'trypsin,': [1390], 'resuspended': [1394], "Hanks'": [1396], 'balanced': [1397], 'salt': [1398], 'solution': [1399, 1412], 'mixed': [1402], 'equal': [1405, 1632, 1845], 'volume': [1406], '0.4%': [1408], 'stain': [1411], 'minutes.': [1415, 1488], 'counted': [1420], 'hemocytometer.': [1422], 'dividing': [1430], 'count': [1434, 2241, 2319], 'immediately': [1435], 'just': [1441], 'before': [1442], 'experiment.': [1447], 'Immunohistochemistry': [1448], '(PCNA)': [1459, 2265], 'three': [1462, 1511, 1544, 1591, 1618, 1658, 1767, 1943, 2244], 'twice': [1466, 1808], 'cold': [1468], 'saline.': [1469], 'Subsequently': [1470], 'fixed': [1477, 1490], '0.3': [1479], 'M': [1480], 'NaCl': [1481], '70%': [1483, 1499], 'ethanol': [1484, 1500], 'alcohol': [1485], '30': [1487, 1525], 'lysed': [1493, 1772], '0.12': [1495], 'N': [1496], 'HCl': [1497], '10': [1502, 1571, 1806, 1989, 3654], 'PBS': [1507, 1523, 1533, 1609, 1649, 1766, 1784], 'times.': [1512], '1%': [1518, 1604, 1635, 1778, 1799], 'normal': [1519, 1605, 3497], 'horse': [1520, 1600, 1606], 'serum': [1521, 1607], 'washing': [1531, 1590, 1617, 1657, 1937, 1975], 'minutes,': [1536], 'mouse': [1545, 1721], 'monoclonal': [1546, 1728, 1920], 'antibodies': [1547, 1723, 1729], 'overnight': [1548], 'temperature': [1551], 'respectively:': [1552], 'anti-p53': [1553, 1919], 'antibody': [1554, 1568, 1580, 1921, 1956], '(Bp53-12': [1555], 'μg/ml,': [1558, 1584, 1925], 'Santa': [1559, 1563, 1585], 'Cruz': [1560, 1586], 'Biotech.': [1561, 1587], 'Inc.,': [1562, 1645, 1906, 2084], 'Cruz,': [1564], 'CA.),': [1565], 'anti-': [1566], '(NCL-bcl-2': [1569], 'μl/ml,': [1572], 'Novocastra': [1573], 'Laboratories': [1574, 1644], 'Ltd.,': [1575], 'Newcastle,': [1576], 'UK),': [1577], 'anti-PCNA': [1579], '(PC10': [1581], 'Inc.).': [1588], 'times,': [1592, 1619, 1659, 1944], '0.5%': [1598, 1665], 'biotinylated': [1599], 'anti-mouse': [1601, 1953], 'IgG': [1602, 1722, 1954], '45': [1611, 1651], 'min': [1612, 1652, 1787, 1942, 1990], 'avidin-biotinylated': [1625], 'peroxidase': [1626], 'complex': [1627], '(ABC)': [1628], 'prepared': [1629], 'combining': [1631], 'amount': [1633, 1846], 'Vectastain': [1636], 'A': [1637, 1819, 2114], 'B': [1639, 3677], '(Vectastain': [1640], 'ABC': [1641], 'kits,': [1642], 'Vector': [1643], 'Burlingame,': [1646], 'CA)': [1647, 2020, 2076], 'diaminobenzidine': [1666], 'hydrochloride': [1667], '(DAB)': [1668], '3%': [1670], 'hydrogen': [1671], 'peroxide': [1672], 'min.': [1675, 1843], 'washing,': [1677], 'counterstained': [1681], 'hematoxylin': [1683], 'mounted.': [1685], 'Lysing': [1686], 'excluded': [1689], 'counting.': [1691], 'Nuclei': [1692, 1706], 'stained': [1693, 1709], 'brown': [1694, 1710], 'defined': [1696, 1712], 'positive': [1698, 1714, 1734, 1749, 2207, 2239, 2284, 2317, 2332, 2367, 2449], 'staining.': [1705, 1719, 2269], 'cytoplasm': [1708], 'Non-specific': [1720], 'instead': [1726], 'negative': [1731, 1741], 'controls.': [1732, 1742], 'No': [1733], 'any': [1740, 3503], 'evaluated': [1746], 'counting': [1748], 'per': [1752], '1,000': [1753], 'Immunoblotting': [1755, 2458, 2612], 'times': [1768], 'medium,': [1771], 'adding': [1774, 1794], '0.5': [1775, 1796], 'ml': [1776, 1797], 'sodium': [1779], 'dodecyl': [1780], 'sulfate': [1781], '(SDS)': [1782], '15': [1786, 3803], 'transferred': [1789], 'microtube.': [1792], 'SDS,': [1800], 'sonicated': [1804], 'sec': [1807], 'temperature,': [1811, 1993], 'collect': [1816], 'supernatant.': [1818], 'concentration': [1821, 1858], 'whole-cell': [1824], 'extract': [1825, 1836, 1853], 'measured': [1827, 2032], 'method': [1830], 'Lowry': [1832, 4034], 'et': [1833, 3565, 3881, 3922, 4170], 'al.22': [1834], 'denatured': [1838], '95°C': [1840], '(5': [1849], 'μg/lane)': [1850], 'separated': [1860], 'SDS-polyacrylamide': [1863], 'gel': [1864], 'electrophoresis,': [1865], 'electrophoretic': [1868], 'polyvinylidene': [1871], 'difluoride': [1872], 'membrane': [1873, 1890, 1915, 1946, 1981], '(Clearblot': [1874], 'P,': [1875], 'Atto': [1876], 'Co.,': [1877, 2018, 2074], 'Tokyo).': [1878], 'Molecular': [1879], 'weight': [1880], 'marker': [1881], 'loaded': [1884], 'detect': [1886], 'protein.': [1888, 2615, 3163], 'blocked': [1892], 'blocking': [1894], 'buffer': [1895, 1939], '(0.5%': [1896], 'Milk': [1897, 1958], 'Block,': [1898], 'Western': [1899], 'Blot': [1900, 1961], 'Kit,': [1901, 1962], 'Kirkegaard': [1902, 1963], '&': [1903, 1964], 'Perry': [1904, 1965], 'Lab.': [1905, 1966], 'Gaithersburg,': [1907], 'MD)': [1908], '4°C': [1910], 'over': [1911], 'night.': [1912], '(DO-1': [1922], '0.2': [1924], 'Oncogene': [1926, 3900, 3943], 'Science,': [1927], 'Uniondale,': [1928], 'NY)': [1929], '0.1%': [1950], 'horseradish': [1951], 'peroxidase-conjugated': [1952], 'goat': [1955], 'Diluent': [1959], '(Western': [1960], 'Inc.)': [1967], 'way,': [1979], 'tetramethylbenzidine': [1985], '(TMB)': [1986], 'substrate': [1987], 'stopping': [1996], 'reaction': [1998], 'distilled': [2000], 'water': [2001], 'dry.': [2004], 'band': [2006, 2466, 2492], 'analyzed': [2009], 'Power': [2012, 2068], 'Macintosh': [2013, 2069], '7500/100': [2014, 2070], 'Computer': [2015, 2017, 2071, 2073], '(Apple': [2016, 2072], 'Cupertino,': [2019, 2075], 'NIH': [2023], 'image': [2024], '1.55': [2025], 'software.': [2026], 'product': [2028, 2048, 2509, 2575, 2593], 'showed': [2034, 2134, 2312, 2489, 2512, 2545], 'relative': [2036, 2514, 2548, 2570, 3838], 'intensity': [2037, 2044, 2515, 2549, 2571], 'average': [2043], 'no': [2050, 2148, 2232, 2528], '5).': [2058, 2505], 'Statistical': [2059], 'analysis': [2060, 2110], 'statistical': [2062, 2102, 2149], 'analyses': [2063, 2810], 'Stat': [2078], 'View': [2079], '4.02J': [2080], 'software': [2081], '(Abacus': [2082], 'Concepts': [2083], 'Berkeley,': [2085], 'CA).': [2086], 'data': [2088, 2855], 'presented': [2090], 'mean': [2093, 2099, 2193, 2278, 2604], '±': [2094, 2194, 2279, 2605], 'standard': [2095, 2108], 'error': [2096], '(SEM).': [2100], 'evaluations': [2103], 'completed': [2105], 'one-way': [2109], 'variance': [2112], '(ANOVA).': [2113], 'p-value': [2115], 'less': [2117], 'than': [2118, 2140, 2169, 2223, 2301, 2320, 2344, 2370, 2475, 2496, 2520, 2554, 2576, 2903], '0.05': [2119, 2560], 'considered': [2121], 'statistically': [2124, 2233, 2529], 'significant.': [2125], 'RESULTS': [2126], 'significantly': [2135, 2213, 2291, 2314, 2338, 2364, 2546, 2568, 2901], 'lower': [2136, 2339], '(p': [2144, 2324, 2350, 2558, 2580], '<': [2145, 2189, 2271, 2274, 2325, 2351, 2559, 2581, 2600], '0.01).': [2146, 2352], 'significance': [2150], 'observed,': [2152], 'tended': [2162], 'show': [2164, 2448, 2745], 'higher': [2165, 2214, 2292, 2315, 2365, 2513, 2547, 2569], 'rates': [2168, 2183], '(Fig.': [2173, 2246, 2327, 2374, 2504, 2583], '1).': [2174], 'Figure': [2175, 2248, 2387, 2389, 2585, 2607], '1Open': [2176], 'figure': [2178, 2251, 2392, 2588, 2610], 'viewerPowerPoint': [2179, 2252, 2393, 2589, 2611], 'groups.': [2187, 2535], '**p': [2188, 2273], '0.01.': [2190], 'Values': [2191, 2276, 2602], 'SEM.': [2195, 2280, 2606], 'Immunohistochemical': [2196, 2376, 2394], 'number': [2205, 2282, 2330], 'There': [2229], 'were,': [2230], 'differences': [2235], 'among': [2242], '2a).': [2247], '2Open': [2249], '(a),': [2257], '(b),': [2259], '(c)': [2266], '*p': [2270, 2599], '0.05;': [2272], '<0.01.': [2275], 'Moreover,': [2307], '0.05)': [2326, 2582], '2b).': [2328], 'Both': [2353, 2480, 2536], 'had': [2363, 2756], 'counts': [2369], '2c).': [2375], 'exhibited': [2385, 2567], '3.': [2388, 4028], '3Open': [2390], 'p53;': [2399], 'group:': [2401, 2404, 2408, 2411, 2415, 2418, 2422, 2425, 2434, 2437, 2441, 2444], 'a-1,': [2402], 'a-2,': [2405], 'a-3,': [2409], 'a-4,': [2412], 'bcl-2;': [2413], 'b-1,': [2416], 'b-2,': [2419], 'b-3,': [2423], 'b-4,': [2426], '(PCNA);': [2432], 'c-1,': [2435], 'c-2,': [2438], 'c-3,': [2442], 'c-4.': [2445], 'Black': [2446], 'arrows': [2447], 'b-1': [2455], 'b-4.': [2457], 'stronger': [2470, 2490], 'Using': [2506], 'densitometry,': [2507], 'although': [2525, 3146], 'difference': [2531], 'between': [2532, 3362], 'two': [2534], 'respectively).': [2561], '4).': [2584], '4Open': [2586], 'Densitometry': [2590], 'analysis.': [2598], '0.05.': [2601], '5Open': [2608], 'a:': [2616], 'b:': [2619], 'c:': [2622], 'd:': [2627], 'DISCUSSION': [2630], 'Oxygen': [2631], 'absolutely': [2633], 'indispensable': [2634], 'optimal': [2636], 'energy': [2637], 'metabolism': [2638], 'mammalian': [2640], 'fact,': [2646], 'cutting': [2647], 'off': [2648], 'oxygen': [2650, 3198], 'supply': [2651], 'lesion': [2655], 'effective': [2661], 'treatments': [2663], '(i.e.,': [2664], 'therapy).': [2667], 'It': [2668], 'evident,': [2670], 'certain': [2673], 'elude': [2677, 3238], 'such': [2678], 'insult.': [2681, 3096], 'Somehow': [2682], 'they': [2683, 2932, 3089, 3156, 3243], 'acquire': [2684], 'grow': [2690], 'decreased': [2705], 'their': [2706, 2726], 'incubation.': [2718, 2737, 2789, 2853, 2870, 2908, 3117, 3144], 'changed,': [2721], 'increase': [2724, 2934, 3051, 3293], 'subsequent': [2734, 2786, 2850, 2867, 2886, 3044], 'proliferation': [2747, 3961], 'well.': [2748], 'findings': [2751, 3221], 'suggest': [2752, 2856], 'some': [2754], 'destined': [2758], 'die': [2760], '(apoptosis),': [2766], 'other': [2769, 3128], 'hypoxia,': [2779], 'began': [2780, 3123], 'again': [2783, 3200], 'production': [2795, 2846, 2937], 'assessed': [2802], 'study.': [2813, 2892], 'This': [2814, 3228], 'finding': [2815], 'consistent': [2817], 'Graeber,': [2821], 'who': [2822], 'reported': [2823, 2913, 2942, 3166], 'accumulation': [2829, 4076], 'cells.23': [2835], 'high': [2841, 3159], 'level': [2842], 'regrew,': [2860], 'overexpression,': [2864], 'Expression': [2871], 'During': [2893, 3018, 3042], 'Shimizu': [2909, 4003], 'Jacobson': [2911, 4105], 'individually': [2912], 'prevented': [2916], 'hypoxia-induced': [2917, 3035, 4017], 'apoptosis.21,': [2918], 'accumulate': [2923], 'Miyashita': [2941, 3830, 3870, 3914], 'condition.17': [2956], 'Whereas,': [2957], 'did': [2965], 'decrease': [2967], 'increasing': [2975], 'Alarcon': [2978, 4129], 'pointed': [2980], 'out': [2981], 'possibility': [2983], 'overexpression': [2985], 'inhibit': [2990], 'accumulation.25': [3000], 'ordinary': [3003], 'pathway,': [3005], 'condition,': [3011], 'condition.': [3017], 'enough': [3031], 'overcome': [3033], 'apoptosis,': [3036], 'participates.': [3041], 'hypoxia.': [3061, 3335, 3468, 3604], 'overexpression.': [3080], 'Reoxygenation': [3081], 'event': [3085], 're-expand': [3090], 'metastasize': [3092], 'These': [3118], 'survived': [3120], 'regrow.': [3125], 'On': [3126], 'hand,': [3129], 'remained': [3139], 'Hence,': [3145], 'accumulated': [3151], 'regrew': [3157], 'Yao': [3164, 3588], 'incubation.8': [3176], 'regrowing': [3178, 3338], 'potential,': [3184], 'participates,': [3189], 'available.': [3201], 'Several': [3202], 'investigators': [3203], 'acquiring': [3210], 'selected': [3214], 'insult.5,': [3218], '26': [3219, 4157], 'do': [3222], 'conflict': [3224], 'hypothesis.': [3227], 'possible': [3229], 'scenario': [3230], 'relevance.': [3233], 'survive,': [3242], 'achieve': [3249], 'malignant': [3251, 3366], 'Treatment': [3253], 'lesions': [3258], 'thus': [3260], 'become': [3261], 'difficult': [3263], 'even': [3265], 'ineffective.': [3266], 'protocol': [3270], 'based': [3271, 3284], 'ineffective': [3283], 'findings.': [3287], 'conclusion,': [3289], 'HCT116.': [3307], 'caused': [3309], 'anti-apoptosis.': [3320], 'Regrowth': [3321], 'REFERENCES': [3347], 'Hockel': [3349, 3386], 'M,': [3350, 3356, 3387, 3591, 3619, 3725, 3875, 3911, 4066], 'Schlenger': [3351, 3390], 'K,': [3352, 3391, 4068], 'Aral': [3353], 'B,': [3354, 3389, 3729], 'Mitze': [3355], 'Schaffer': [3357], 'U,': [3358], 'Vaupel': [3359], 'P.': [3360], 'Association': [3361], 'progression': [3367], 'advanced': [3369, 3404], 'uterine': [3373, 3408], 'cervix.': [3374, 3409], 'Res': [3376, 3512, 3860, 4148, 4187], '1996;': [3377, 3579, 4149], '56:': [3378, 4150], '4509–': [3379], '15.': [3380], 'CASPubMedWeb': [3381, 3865, 3905, 3948, 4153, 4192], 'Science®Google': [3383, 3418, 3450, 3478, 3519, 3550, 3585, 3615, 3652, 3686, 3721, 3744, 3774, 3801, 3827, 3867, 3907, 3950, 3974, 4000, 4031, 4058, 4102, 4126, 4155, 4194], 'Scholar': [3384, 3419, 3451, 3479, 3520, 3551, 3586, 3616, 3653, 3687, 3722, 3745, 3775, 3802, 3828, 3868, 3908, 3951, 3975, 4001, 4032, 4059, 4103, 4127, 4156, 4195], 'Vorndran': [3388], 'Baussmann': [3392], 'E,': [3393, 3525, 3527, 3690], 'Knapstein': [3394], 'PG.': [3395], 'Tumor': [3396, 3883], 'oxygenation:': [3397], 'new': [3399], 'predictive': [3400], 'parameter': [3401], 'locally': [3403], 'Gynecol': [3410], 'Oncol': [3411, 3817], '1993;': [3412, 3795], '51:': [3413], '141–': [3414], '9.': [3415, 3547, 3798, 4152], 'CrossrefCASPubMedWeb': [3416, 3448, 3476, 3517, 3548, 3583, 3613, 3684, 3719, 3742, 3772, 3799, 3972, 3998, 4029, 4056, 4100, 4124], 'Young': [3421], 'SD,': [3422], 'Marshall': [3423], 'RS,': [3424], 'Hill': [3425], 'RP.': [3426], 'induces': [3428, 3703, 4075], 'DNA': [3429, 3850, 3991], 'overreplication': [3430], 'enhances': [3432], 'metastatic': [3433], 'murine': [3436], 'Proc': [3439, 3790], 'Natl': [3440, 3606, 3791], 'Acad': [3441, 3792], 'Sci': [3442, 3679, 3793], 'USA': [3443, 3794], '1988;': [3444, 3768], '85:': [3445], '9533–': [3446], '7.': [3447, 3718, 3997], '4': [3452], 'Schmaltz': [3453], 'C,': [3454, 3556, 4163], 'Hardenbergh': [3455], 'PH,': [3456], 'Wells': [3457], 'A,': [3458, 3698], 'Fisher': [3459], 'D.': [3460], 'Regulation': [3461], 'proliferation-survival': [3463], 'decisions': [3464], 'Mol': [3469, 3642, 4093], 'Biol': [3471, 3678, 4050, 4095], '1998;': [3472, 3644], '18:': [3473], '2845–': [3474], '54.': [3475], 'Amellem': [3481], 'O,': [3482], 'Stokke': [3483], 'T,': [3484, 3558, 3660, 3831, 3871, 3915], 'Sandvik': [3485], 'JA,': [3486], 'Smedshammer': [3487], 'L,': [3488, 3696], 'Pettersen': [3489], 'EO.': [3490], 'Hypoxia-induced': [3491], 'status': [3499], 'function,': [3501], 'without': [3502], 'alteration': [3504], 'level.': [3509], 'Exp': [3510], '1997;': [3513, 3544, 4188], '232:': [3514], '361–': [3515], '70.': [3516], '6': [3521], 'Ferrer': [3522], 'Pozas': [3524], 'Lopez': [3526], 'Ballabriga': [3528], 'J.': [3529], 'Bcl-2,': [3530], 'Bax': [3531], 'Bcl-x': [3533], 'hypoxia-ischemia': [3536], 'infant': [3539], 'rat': [3540], 'brain.': [3541], 'Acta': [3542], 'Neuropathol': [3543], '94:': [3545], '583–': [3546], '7': [3552], 'Graeber': [3553, 4061, 4133], 'TG,': [3554, 4062, 4134, 4165], 'Osmanian': [3555, 4162], 'Jacks': [3557], 'Housman': [3559], 'DE,': [3560], 'Koch': [3561], 'CJ,': [3562], 'Lowe': [3563], 'SW,': [3564], 'al.': [3566, 3882, 3923, 4171], 'Hypoxia-mediated': [3567], 'selection': [3568], 'diminished': [3572], 'tumors.': [3577], 'Nature': [3578, 3714, 3767, 3993, 4024, 4119], '379:': [3580], '88–': [3581], '91.': [3582], '8': [3587], 'KS,': [3589], "O'Dwyer": [3592], 'PJ.': [3593], 'Apoptosis': [3594], 'adenocarcinoma': [3597], 'HT29': [3598], 'J': [3605, 3965, 4049], 'Inst': [3608], '1995;': [3609, 3821, 4025, 4120], '87:': [3610], '117–': [3611], '22.': [3612], '9': [3617], 'Olivier': [3618], 'Bautista': [3620], 'S,': [3621, 3750, 3873, 3919, 4004], 'Valles': [3622], 'H,': [3623, 4008, 4012], 'Theillet': [3624], 'C.': [3625], 'Relaxed': [3626], 'cell-cycle': [3627], 'arrests': [3628], 'propagation': [3630], 'unrepaired': [3632], 'chromosomal': [3633], 'wild-type': [3640], 'Carcinog': [3643], '23:': [3645], '1–': [3646], '12.': [3647], 'LibraryCASPubMedWeb': [3650], 'Lane': [3655], 'DP,': [3656], 'Lu': [3657], 'X,': [3658], 'Hupp': [3659], 'Hall': [3661, 3953], 'PA.': [3662], 'role': [3664], 'response.': [3671], 'Philos': [3672], 'Trans': [3673], 'R': [3674], 'Soc': [3675], 'Lond': [3676], '1994;': [3680, 3901, 3944, 4096], '345:': [3681], '277–': [3682], '80.': [3683], '11': [3688], 'Yonish-Rouach': [3689], 'Resnitzky': [3691], 'D,': [3692, 3727], 'Lotem': [3693], 'J,': [3694], 'Sachs': [3695], 'Kimchi': [3697], 'Oren': [3699], 'M.': [3700], 'myeloid': [3706], 'leukemic': [3707], 'inhibited': [3711], 'interleukin-6.': [3713], '1991;': [3715, 3738], '352:': [3716], '345–': [3717], '12': [3723], 'Hollstein': [3724], 'Sidransky': [3726], 'Vogelstein': [3728], 'Harris': [3730], 'CC.': [3731], 'mutations': [3733], 'cancers.': [3736], 'Science': [3737], '253:': [3739], '49–': [3740], '53.': [3741], '13': [3746], 'Vaux': [3747, 3777], 'DL,': [3748], 'Cory': [3749], 'Adams': [3751], 'JM.': [3752], 'Bcl-2': [3753, 3834, 4021], 'promotes': [3755], 'haemopoietic': [3756], 'cooperates': [3760], 'c-myc': [3762], 'immortalize': [3764], 'pre-B': [3765], '335:': [3769], '440–': [3770], '2.': [3771], 'DL.': [3778], 'Toward': [3779], 'understanding': [3781], 'molecular': [3784], 'mechanisms': [3785], 'physiological': [3787], 'death.': [3789], '90:': [3796], '786–': [3797], 'Reed': [3804, 3832, 3920], 'JC.': [3805, 3833], 'Bcl-2:': [3806], 'prevention': [3807], 'mechanism': [3812], 'drug': [3814], 'resistance.': [3815], 'Hematol': [3816], 'Clin': [3818, 3966], 'North': [3819], 'Am': [3820], '9:': [3822, 3902, 3945], '451–': [3823], '73.': [3824], 'CrossrefPubMedWeb': [3825], 'increases': [3837], 'S49.1': [3841], 'WEHI7.2': [3843], 'lymphoid': [3844], 'fragmentation': [3851], 'glucocorticoids': [3854], 'multiple': [3856], 'drugs.': [3858], '1992;': [3861], '52:': [3862], '5407–': [3863], '11.': [3864], '17': [3869], 'Krajewski': [3872, 3918], 'Krajewska': [3874], 'Wang': [3876, 3916], 'HG,': [3877, 3917], 'Lin': [3878, 3912], 'HK,': [3879, 3913], 'Liebermann,': [3880], 'suppressor': [3884], 'regulator': [3888], 'vitro': [3896], 'vivo.': [3899, 4146], '1799–': [3903], '805.': [3904], 'Selvakumaran': [3910], 'JC,': [3921], 'Immediate': [3924], 'early': [3925], 'TGF': [3934], 'beta': [3935], '1:': [3936], 'paradigm': [3938], 'distinct': [3940], '1791–': [3946], '8.': [3947], '19': [3952], 'PA,': [3954, 3982], 'Levison': [3955], 'DA.': [3956], 'Review:': [3957], 'assessment': [3958], 'histological': [3963], 'material.': [3964], 'Pathol': [3967], '1990;': [3968], '43:': [3969], '184–': [3970], '92.': [3971], 'Bravo': [3977], 'R,': [3978, 3980], 'Frank': [3979], 'Blundell': [3981], 'MacDonald-Brand': [3983], 'Cyclin/PCNA': [3985], 'auxiliary': [3988], 'polymerase-delta.': [3992], '1987;': [3994], '326:': [3995], '515–': [3996], 'Eguchi': [4005], 'Y,': [4006], 'Kosaka': [4007], 'Kamiike': [4009], 'W,': [4010], 'Matsuda': [4011], 'Tsujimoto': [4013], 'Y.': [4014], 'Prevention': [4015], 'Bcl-xL.': [4023], '374:': [4026, 4121], '811–': [4027], '22': [4033], 'OH,': [4035], 'Rosebrough': [4036], 'NJ,': [4037], 'Farr': [4038], 'AL,': [4039], 'Randall': [4040], 'RJ.': [4041], 'measurement': [4043], 'Folin': [4046], 'phenol': [4047], 'reagent.': [4048], 'Chem': [4051], '1951;': [4052], '193:': [4053], '265–': [4054], '75.': [4055], '23': [4060], 'Peterson': [4063], 'JF,': [4064], 'Tsai': [4065, 4160], 'Monica': [4067], 'Fornace': [4069], 'AJ': [4070], 'Jr,': [4071], 'Giaccia': [4072, 4137], 'AJ.': [4073, 4138], 'protein,': [4079], 'activation': [4081], 'G1-phase': [4083], 'checkpoint': [4084], 'low-oxygen': [4086, 4184], 'independent': [4089], 'status.': [4092], '14:': [4097], '6264–': [4098], '77.': [4099], 'MD,': [4106], 'Raff': [4107], 'MC.': [4108], 'Programmed': [4109], 'protection': [4114], 'very': [4116], 'low': [4117], 'oxygen.': [4118], '814–': [4122], '6.': [4123], '25': [4128], 'RM,': [4130], 'Rupnow': [4131], 'BA,': [4132], 'Knox': [4135], 'SJ,': [4136], 'Modulation': [4139], 'c-Myc': [4141], 'activity': [4142], '4315–': [4151], 'Kim': [4158], 'CY,': [4159], 'MH,': [4161], 'Graber': [4164], 'JE,': [4167], 'Giffard': [4168], 'RG,': [4169], 'Selection': [4172], 'cervical': [4175], 'epithelial': [4176], 'possess': [4179], 'reduced': [4180], '57:': [4189], '4200–': [4190], '4.': [4191], 'Citing': [4196], 'Literature': [4197], 'Volume91,': [4198], 'Issue31': [4199], 'February': [4200], '2001Pages': [4201], 'FiguresReferencesRelatedInformation': [4203]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1966878834', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-12-29T23:09:05.663922', 'created_date': '2016-06-24'}
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