Publication Information

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240, 436, 558, 1560, 1989, 2723, 3980, 4080, 4151, 4364], 'share': [6, 241, 1946, 3168], 'the': [7, 29, 35, 53, 68, 138, 142, 162, 166, 174, 178, 191, 200, 223, 232, 242, 264, 270, 288, 303, 373, 377, 397, 401, 409, 413, 426, 435, 458, 467, 475, 477, 524, 644, 656, 681, 716, 721, 860, 913, 942, 993, 1171, 1263, 1298, 1394, 1412, 1521, 1584, 1641, 1834, 1884, 1910, 1941, 1947, 1970, 1986, 2031, 2039, 2058, 2068, 2075, 2099, 2140, 2146, 2152, 2167, 2177, 2197, 2210, 2233, 2247, 2267, 2276, 2285, 2289, 2306, 2315, 2427, 2433, 2495, 2640, 2645, 2650, 2655, 2708, 2830, 2840, 2864, 2877, 2884, 2917, 2956, 3017, 3028, 3047, 3102, 3124, 3151, 3176, 3187, 3318, 3557, 3594, 3603, 3644, 3654, 3658, 3682, 3686, 3690, 3698, 3718, 3812, 3870, 3883, 3926, 3931, 3935, 3941, 3949, 3960, 3970, 3975, 4010, 4042, 4046, 4052, 4070, 4087, 4130, 4138, 4150, 4153, 4164, 4173, 4178, 4193, 4197, 4203, 4233, 4245, 4251, 4255, 4276, 4281, 4292, 4298, 4306, 4312, 4319, 4330, 4337, 4346, 4350, 4363], 'same': [8, 243, 525, 1299, 1948], 'core': [9, 244, 526, 1949, 3867, 3873], 'fusion': [10, 245, 514, 554, 665, 697, 2380, 2922, 2924, 4040, 4057, 4101], 'machinery': [11, 246, 555, 1951, 2148], 'consisting': [12, 247], 'of': [13, 34, 55, 72, 121, 141, 145, 156, 165, 202, 231, 248, 269, 290, 307, 356, 376, 380, 391, 400, 437, 466, 559, 694, 715, 720, 863, 910, 944, 997, 1101, 1223, 1397, 1517, 1523, 1526, 1587, 1624, 1643, 1833, 1883, 1897, 1909, 1973, 1978, 2041, 2077, 2098, 2102, 2129, 2132, 2142, 2145, 2154, 2169, 2190, 2200, 2235, 2246, 2256, 2266, 2293, 2318, 2363, 2370, 2432, 2498, 2576, 2642, 2652, 2654, 2664, 2817, 2822, 2829, 2839, 2874, 2880, 2914, 2959, 3030, 3106, 3194, 3198, 3307, 3436, 3469, 3556, 3591, 3602, 3614, 3646, 3685, 3759, 3795, 3800, 3817, 3860, 3925, 3944, 3954, 3962, 3974, 3978, 4002, 4058, 4090, 4115, 4122, 4132, 4152, 4156, 4172, 4196, 4214, 4236, 4244, 4286, 4291, 4303, 4321, 4334, 4357, 4366], 'SNARE': [14, 249, 527, 634, 682, 2201, 2919, 3049], '(soluble': [15, 250, 547], 'N-ethylmaleimide-sensitive': [16, 251, 533, 548], 'factor': [17, 252, 534, 549, 4253], 'attachment': [18, 253, 535, 551], 'protein': [19, 38, 254, 273, 536, 552, 652, 894, 1227, 1651, 2072, 2657, 2710, 3170, 3179, 3505, 3606, 3656, 3688, 3918, 4020, 4176, 4180, 4206, 4227, 4294], 'receptor)': [20, 255, 553], 'proteins.': [21, 168, 256, 403], 'In': [22, 149, 257, 384, 760, 2022, 2214, 3793], 'evoked': [23, 258, 950, 2502, 2574], 'neurotransmission,': [24, 259], 'interactions': [25, 260, 3253], 'between': [26, 261, 3101, 3593, 3689], 'SNAREs': [27, 262, 3154], 'Munc18-1': [30, 56, 73, 90, 103, 112, 133, 171, 213, 265, 291, 308, 325, 338, 347, 368, 406, 448, 763, 893, 945, 998, 1092, 1161, 1303, 1644, 2110, 2212, 2435, 2566, 2656, 2665, 2709, 2841, 2871, 2915, 2960, 3107, 3308, 3454, 3604, 3655, 3687, 3724, 3818, 3851, 3892, 3917, 3985, 4013, 4036, 4116, 4174, 4264, 4269, 4293, 4343, 4358], 'protein,': [31, 266, 1169], 'a': [32, 186, 206, 229, 267, 421, 441, 464, 482, 704, 713, 1098, 1167, 1175, 1220, 1225, 1409, 1514, 1672, 1678, 1890, 2026, 2187, 2262, 2368, 2438, 2570, 2620, 2625, 2636, 2820, 3031, 3192, 3466, 3507, 3563, 3588, 3600, 3757, 3857, 3879, 3990, 4018, 4225, 4241, 4326], 'member': [33, 268, 714], 'Sec1/Munc18': [36, 271], '(SM)': [37, 272], 'family,': [39, 274], 'are': [40, 48, 275, 283, 687, 1645, 2356, 2658, 3108, 3679, 4032], 'essential': [41, 276, 2059, 2348], 'for': [42, 181, 277, 416, 680, 903, 908, 1738, 2034, 2227, 2237, 2275, 2349, 3681, 3762, 4034, 4162, 4254, 4284], 'exocytosis,': [43, 278, 1975, 3240], 'whereas': [44, 279, 1170], 'other': [45, 280, 1398, 3699, 4047, 4338], 'SM': [46, 281], 'proteins': [47, 282, 686, 1626, 2204, 2220, 3438, 3559, 4073], 'dispensable.': [49, 284], 'To': [50, 285, 2055, 3549], 'address': [51, 286], 'if': [52, 287, 2057, 3551], 'exclusivity': [54, 289], 'demonstrated': [57, 292, 1511, 1729, 2569, 2671, 3249, 3506], 'in': [58, 79, 105, 158, 185, 293, 314, 340, 393, 420, 474, 481, 490, 516, 519, 700, 708, 941, 946, 999, 1185, 1229, 1262, 1411, 1520, 1528, 1583, 1681, 1683, 1735, 1746, 1894, 1905, 1967, 2062, 2138, 2175, 2206, 2223, 2241, 2284, 2302, 2323, 2354, 2367, 2373, 2377, 2561, 2635, 2667, 2677, 2706, 2811, 2814, 2848, 2863, 2883, 2965, 3163, 3173, 3186, 3232, 3242, 3314, 3317, 3443, 3457, 3695, 3712, 3720, 3735, 3807, 3885, 3921, 3930, 3981, 3988, 3994, 4023, 4096, 4146, 4220, 4229, 4259, 4271], 'neuroexocytosis': [59, 294], 'also': [60, 295, 777, 851, 907, 1094, 1260, 1386, 1733, 2067, 2217, 2342, 2853, 3120, 3183, 3670, 3822, 4061], 'applied': [61, 296], 'to': [62, 107, 193, 297, 342, 428, 492, 661, 689, 762, 898, 912, 1165, 1392, 1419, 1512, 1630, 1639, 1969, 2024, 2047, 2051, 2074, 2166, 2181, 2279, 2494, 2633, 2714, 2876, 3024, 3044, 3110, 3123, 3250, 3512, 3565, 3607, 3729, 3745, 3787, 3802, 3876, 3934, 3999, 4148, 4182, 4210, 4297, 4314, 4325, 4349, 4373], 'fast': [63, 298], 'insulin': [64, 146, 224, 299, 381, 459, 489, 517, 1102, 1588, 1747, 1958, 1979, 2029, 2036, 2078, 2103, 2114, 2171, 2257, 2722, 2831, 3195, 3471], 'secretion,': [65, 300, 2030, 2115], 'we': [66, 151, 301, 386, 2082, 3568, 3785], 'characterized': [67, 302, 2083, 2288], 'presence': [69, 304, 2153, 2234], 'function': [71, 306, 1642, 2179, 2666, 3125], 'its': [75, 310, 1824, 3705], 'closest': [76, 311, 861], 'homologue': [77, 312, 719, 862, 1172, 2365], 'Munc18-2': [78, 114, 135, 189, 215, 313, 349, 370, 424, 450, 772, 1173, 1182, 1296, 1388, 1415, 2071, 2112, 2319, 3147, 3227, 3310, 3702, 3726, 3820, 4049, 4118, 4123, 4179], 'β-cell': [80, 315, 479, 1265, 2277], 'stimulus-secretion': [81, 316], 'coupling.': [82, 317], 'We': [83, 318, 2105, 2134, 2230, 3449, 3598, 3939], 'show': [84, 131, 319, 366, 2869, 3160, 3587], 'that': [85, 132, 153, 320, 367, 388, 556, 654, 1387, 1635, 1676, 1730, 1892, 1943, 2108, 2137, 2232, 2314, 2429, 2440, 2614, 2847, 2870, 3453, 4012, 4056, 4069, 4079, 4144, 4202, 4222], 'pancreatic': [86, 321, 478, 1230, 1750, 2173, 3243, 3458, 3982], 'β-cells': [87, 159, 322, 394, 520, 1751, 1945, 1965, 2045, 2139, 2195, 2216, 2242, 2815, 3459, 3516], 'express': [88, 323, 2196, 2218], 'both': [89, 111, 324, 346, 2109, 2499, 2619, 2672, 2716, 3149, 3190, 3674, 3701, 3711, 3723, 3922], 'Munc18-2.': [92, 327, 2229], 'The': [93, 328, 2311, 2334, 3503, 3733, 4288], 'two': [94, 329, 765, 1835, 3152, 4097], 'Munc18': [95, 167, 330, 402, 717, 1625, 2156, 2295, 2364, 3558, 3581, 3584, 3596, 3963, 4072, 4223], 'homologues': [96, 331], 'exhibit': [97, 332, 3856], 'different': [98, 333, 1690, 1982, 2052, 2155, 2668, 2823, 2827, 2837, 3103, 3595, 4071, 4076, 4084, 4100, 4108], 'subcellular': [99, 218, 334, 453, 2125, 3508, 3721], 'localization,': [100, 335, 3722], 'only': [102, 337, 902, 2224, 3790], 'redistributes': [104, 339], 'response': [106, 341, 491, 3564], 'glucose': [108, 343, 472, 2282, 3520, 3612], 'stimulation.': [109, 344, 3672], 'However,': [110, 345, 991, 2559, 3016, 3869, 4216], 'augment': [115, 350, 3730], 'glucose-stimulated': [116, 351, 3715, 3731], 'release.': [118, 353], 'Ramp-like': [119, 354], 'photorelease': [120, 355, 3953], 'caged': [122, 357, 3955], 'Ca2+': [123, 139, 154, 179, 195, 209, 358, 374, 389, 414, 430, 444, 2096, 2130, 2143, 3199, 3956, 4030, 4053, 4065, 4277, 4282, 4316, 4347], 'high': [125, 360, 2322, 3032, 3589, 3950], 'resolution': [126, 361, 3951], 'whole-cell': [127, 362], 'patch': [128, 363], 'clamp': [129, 364], 'recordings': [130, 365], 'overexpression': [136, 371, 4050, 4356], 'shift': [137, 372, 4313], 'sensitivity': [140, 155, 196, 375, 390, 431, 2097, 2131, 2144, 4054, 4348], 'fastest': [143, 378, 1971, 2100, 3942, 4088, 4154, 4194, 4234], 'phase': [144, 379, 1586, 1972, 2101, 3943, 4089, 4155, 4195, 4213, 4235], 'exocytosis': [147, 157, 382, 392, 518, 905, 1001, 1423, 2037, 2079, 2632, 2679, 3472, 3946, 4091], 'differently.': [148, 383], 'addition,': [150, 385, 2215], 'reveal': [152, 387], 'depends': [160, 395], 'on': [161, 396, 2095, 2118, 2151, 2329, 2721, 3020, 3789, 3969, 4192, 4329], 'phosphorylation': [163, 398, 2120, 2160, 3554, 3651, 3707, 3966, 4266, 4323], 'status': [164, 399], 'Even': [169, 404, 2480], 'though': [170, 405, 2481], 'emerges': [172, 407], 'as': [173, 228, 408, 463, 1097, 1219, 1302, 1402, 1952, 2090, 2092, 2347, 3191, 3465, 3562, 3583], 'key': [175, 410, 705, 2060], 'SM-protein': [176, 411], 'determining': [177, 412], 'threshold': [180, 415, 2033], 'triggering': [182, 417, 2032, 4285], 'secretory': [183, 418, 1395, 2239, 2268, 2622, 2832, 2856, 4024, 4140, 4256], 'activity': [184, 419, 3119, 3201, 3678], 'stimulated': [187, 422, 1988, 2035, 3518, 3861, 4380], 'β-cell,': [188, 423, 2174], 'has': [190, 425, 895, 1093, 1174, 1216, 1389, 1416, 1509, 1627, 1728, 2711, 3182, 3228, 3247, 3311, 3821], 'ability': [192, 427, 2278], 'increase': [194, 429, 1393, 3734], 'thus': [198, 433, 3041, 4360], 'mediates': [199, 434, 557], 'fusion-competent': [203, 438], 'granules': [204, 439, 4059, 4134], 'requiring': [205, 440], 'lower': [207, 442, 4064], 'cytoplasmic-free': [208, 443], 'concentration,': [210, 445], '[Ca2+]i.': [211, 234, 446, 469, 4085], 'Hence,': [212, 447], 'display': [216, 451, 2123], 'distinct': [217, 452, 1906, 2124], 'compartmentalization': [219, 454, 2089], 'can': [221, 456, 954, 3148], 'coordinate': [222, 457], 'exocytotic': [225, 460, 1911, 1950, 2147, 2219, 3437, 3927, 4198], 'process': [226, 461, 1912], 'differently': [227, 462], 'consequence': [230, 465, 2821], 'actual': [233, 468, 3936], 'IntroductionTo': [470], 'maintain': [471], 'homeostasis': [473, 2283], 'body,': [476], 'must': [480], 'controlled': [483], 'way': [484], 'produce,': [485], 'store,': [486], 'secrete': [488, 2184], 'appropriate': [493], 'stimuli': [494], '(1Leibiger': [495], 'I.B.': [496], 'Leibiger': [497], 'B.': [498, 581, 1121, 1363, 2741, 3361, 3830, 3900], 'Berggren': [499, 578, 1118, 1762, 1790, 2738, 2790, 3483, 3529], 'P.O.': [500, 579, 1119, 1763, 1791, 2739, 2791, 3484, 3530], 'Annu.': [501], 'Rev.': [502, 1697], 'Nutr.': [503], '2008;': [504, 604, 1048, 3635, 3776], '28:': [505, 1816], '233-251Crossref': [506], 'PubMed': [507, 590, 607, 627, 674, 755, 795, 831, 845, 886, 935, 986, 1032, 1051, 1066, 1087, 1133, 1155, 1210, 1254, 1291, 1326, 1353, 1378, 1445, 1499, 1554, 1577, 1606, 1619, 1667, 1704, 1720, 1777, 1805, 1818, 1860, 1874, 1935, 1996, 2017, 2401, 2419, 2475, 2535, 2554, 2606, 2699, 2753, 2775, 2805, 2906, 2947, 2986, 3011, 3070, 3095, 3141, 3222, 3279, 3301, 3351, 3373, 3398, 3431, 3498, 3544, 3638, 3779, 3842, 3912], 'Scopus': [508, 591, 608, 628, 675, 756, 796, 832, 846, 887, 936, 987, 1033, 1052, 1067, 1088, 1134, 1156, 1211, 1292, 1327, 1354, 1379, 1446, 1500, 1555, 1578, 1607, 1620, 1705, 1721, 1778, 1806, 1819, 1875, 1936, 1997, 2018, 2402, 2420, 2476, 2536, 2555, 2607, 2700, 2754, 2776, 2806, 2907, 2948, 2987, 3012, 3071, 3096, 3142, 3223, 3302, 3352, 3374, 3399, 3432, 3499, 3545, 3639, 3780, 3843, 3913], '(165)': [509], 'Google': [510, 593, 610, 630, 677, 758, 798, 834, 848, 889, 938, 989, 1035, 1054, 1069, 1090, 1136, 1158, 1213, 1255, 1294, 1329, 1356, 1381, 1448, 1502, 1557, 1580, 1609, 1622, 1668, 1707, 1723, 1780, 1808, 1821, 1861, 1877, 1938, 1999, 2020, 2404, 2422, 2478, 2538, 2557, 2609, 2702, 2756, 2778, 2808, 2909, 2950, 2989, 3014, 3073, 3098, 3144, 3225, 3280, 3304, 3354, 3376, 3401, 3434, 3501, 3547, 3641, 3782, 3845, 3915], 'Scholar).': [511, 631, 678, 759, 849, 939, 990, 1159, 1256, 1295, 1382, 1503, 1669, 1724, 1822, 1878, 1939, 2021, 2423, 2479, 2558, 2610, 2703, 2809, 2910, 2951, 3015, 3099, 3226, 3305, 3502, 3548, 3642, 3846], 'Regulated': [512], 'membrane': [513, 646, 696, 915, 2350, 2379, 3178, 3444, 3609, 3660, 3884, 3937], 'resulting': [515], 'is': [521, 711, 859, 1162, 1183, 1385, 1505, 1671, 1732, 1827, 1881, 1889, 2180, 2186, 2271, 2846, 2872, 3022, 3455, 3743, 3799, 3919, 4160, 4207, 4224, 4309, 4371], 'managed': [522], 'by': [523, 647, 1304, 1687, 3113, 3519, 3620, 3755, 3947, 4009, 4127, 4185, 4311], '3The': [528], 'abbreviations': [529], 'used': [530, 3569], 'are:': [531], 'SNAREsoluble': [532], 'receptorCdk5cyclin-dependent': [537], 'kinase': [538, 1647, 1652, 1675, 1891, 3118], '5hGHhuman': [539], 'growth': [540], 'hormoneHCRPhigh': [541], 'Ca2+-requiring': [542, 544], 'poolLCRPlow': [543], 'poolAUarbitrary': [545], 'units.': [546], '(NSF)': [550], 'chemical': [560], 'signals': [561], 'at': [562, 3657, 3878, 4063, 4083], 'highly': [563, 1953, 2357], 'specialized': [564, 1954], 'central': [565], 'neuronal': [566, 947, 1168, 1955, 2207, 2211], 'synapses': [567], '(2Jacobsson': [568], 'G.': [569, 1111, 1482, 1484, 1492, 1761, 2731, 2789, 3482], 'Bean': [570], 'A.J.': [571], 'Scheller': [572], 'R.H.': [573], 'Juntti-Berggren': [574, 1788, 3527], 'L.': [575, 1145, 1239, 1753, 1783, 1789, 2765, 2781, 3264, 3404, 3412, 3414, 3474, 3522, 3528], 'Deeney': [576], 'J.T.': [577, 1532], 'Meister': [580, 1120, 2740], 'Proc.': [582, 2939, 3003, 3087], 'Natl.': [583, 2940, 3004, 3088], 'Acad.': [584, 930, 2694, 2941, 3005, 3089], 'Sci.': [585, 931, 1374, 2695, 2942, 3006, 3090], 'U.S.A.': [586, 2943, 3007, 3091], '1994;': [587], '91:': [588], '12487-12491Crossref': [589], '(194)': [592], 'Scholar,': [594, 611, 799, 835, 1036, 1055, 1070, 1137, 1330, 1357, 1449, 1610, 1708, 1781, 1809, 1862, 2000, 2405, 2539, 2757, 2779, 2990, 3074, 3281, 3355, 3377, 3402], '3Gauthier': [595], 'B.R.': [596], 'Wollheim': [597], 'C.B.': [598], 'Am.': [599, 1596, 2007], 'J.': [600, 784, 803, 819, 820, 840, 875, 1059, 1082, 1122, 1191, 1205, 1280, 1315, 1334, 1348, 1369, 1372, 1493, 1543, 1597, 1757, 1766, 1794, 1842, 1855, 2008, 2549, 2590, 2742, 2785, 2794, 2895, 2938, 2975, 3002, 3059, 3086, 3209, 3290, 3340, 3381, 3478, 3487, 3533], 'Physiol.': [601, 1598, 1602, 2009, 2013], 'Endocrinol.': [602], 'Metab.': [603, 1440], '295:': [605], 'E1279-E1286Crossref': [606], '(77)': [609], '4Jahn': [612], 'R.': [613, 1042, 1078, 1693, 2411, 3379, 3387, 3629, 3770], 'Lang': [614, 1075], 'T.': [615, 805, 809, 1076, 1568, 2579, 2588, 3287, 3406], 'Südhof': [616, 749, 782, 873, 980, 1026, 1313, 2469, 2529, 2591, 2935, 2999, 3083], 'T.C.': [617, 667, 750, 783, 874, 981, 1027, 1314, 2470, 2530, 2592, 2936, 3000, 3084], 'Cell.': [618, 1250, 2412, 3275, 3369, 3427, 3838, 3908], '2003;': [619, 1375, 2393], '112:': [620], '519-533Abstract': [621], 'Full': [622, 624, 790, 792, 826, 828, 881, 883, 1128, 1130, 1286, 1288, 1321, 1323, 1549, 1551, 1772, 1774, 1800, 1802, 2396, 2398, 2416, 2601, 2603, 2748, 2750, 2800, 2802, 2901, 2903, 2981, 2983, 3065, 3067, 3136, 3138, 3296, 3298, 3346, 3348, 3493, 3495, 3539, 3541], 'Text': [623, 625, 791, 793, 827, 829, 882, 884, 1129, 1131, 1287, 1289, 1322, 1324, 1550, 1552, 1773, 1775, 1801, 1803, 2397, 2399, 2417, 2602, 2604, 2749, 2751, 2801, 2803, 2902, 2904, 2982, 2984, 3066, 3068, 3137, 3139, 3297, 3299, 3347, 3349, 3494, 3496, 3540, 3542], 'PDF': [626, 794, 830, 885, 1132, 1290, 1325, 1553, 1776, 1804, 2400, 2418, 2605, 2752, 2804, 2905, 2985, 3069, 3140, 3300, 3350, 3497, 3543], '(1213)': [629], 'Three': [632], 'conserved': [633, 2358, 3169], 'proteins,': [635, 683, 2344], 'VAMP2,': [636], 'syntaxin': [637, 1300, 1306, 1518, 2300, 2336, 2861, 2881, 3155, 3180], '1A,': [638, 1307], 'SNAP-25,': [640], 'connect': [641], 'vesicles': [642, 911, 3874], 'with': [643, 1831, 1985, 2916, 3462, 3617, 3804, 3888, 4015, 4041, 4107, 4273, 4342, 4354], 'plasma': [645, 914, 3177, 3608, 3659, 4043], 'forming': [648], 'an': [649, 1901, 2191, 2272, 2962, 3440], 'exceptionally': [650], 'stable': [651, 4019], 'complex': [653, 2920, 3050, 4021], 'holds': [655], 'intrinsic,': [657], 'but': [658, 906, 2066, 2572, 3740, 3784, 4318], 'slow,': [659], 'capability': [660], 'perform': [662], 'lipid': [663], 'bilayer': [664], '(5Südhof': [666], 'Rothman': [668], 'J.E.': [669, 1044, 3631, 3772], 'Science.': [670, 751, 982, 1028, 1062, 2471, 2531], '2009;': [671, 932, 1283, 1496, 1616, 1993, 2696, 3343, 3428], '323:': [672], '474-477Crossref': [673], '(1431)': [676], 'Except': [679], 'additional': [684, 1962, 2844, 3747], 'cooperating': [685], 'critical': [688], 'guarantee': [690], 'speed': [691], 'accuracy': [693], 'diverse': [695], 'events': [698, 3932], 'occurring': [699], 'excitable': [701, 2616], 'cells.': [702, 3573], 'Such': [703], 'accessory': [706], 'regulator': [707, 1100, 2061, 3468], 'synaptic': [709, 2063, 2503], 'transmission': [710, 2504], 'Munc18-1,': [712, 864, 2065], '(mammalian': [718, 856], 'unc-18': [722], 'gene)': [723], 'family': [724], '(6Verhage': [725, 956, 1002, 2445, 2505], 'M.': [726, 746, 815, 817, 957, 977, 1003, 1023, 1237, 1365, 1437, 1439, 1451, 1465, 2389, 2446, 2466, 2506, 2526, 2545, 2596, 2930, 2994, 3078, 3130, 3262, 3283, 3367, 3383, 3836, 3906], 'Maia': [727, 958, 1004, 2447, 2507, 2542, 3358, 3827, 3897], 'A.S.': [728, 959, 1005, 2448, 2508, 2543, 3359, 3828, 3898], 'Plomp': [729, 960, 1006, 2449, 2509], 'J.J.': [730, 961, 1007, 2450, 2510], 'Brussaard': [731, 962, 1008, 2451, 2511], 'A.B.': [732, 963, 1009, 1850, 2452, 2512], 'Heeroma': [733, 964, 1010, 2453, 2513], 'J.H.': [734, 965, 1011, 1866, 2454, 2514], 'Vermeer': [735, 966, 1012, 2455, 2515], 'H.': [736, 801, 807, 967, 1013, 1115, 1570, 2456, 2516, 2586, 2735, 3289], 'Toonen': [737, 968, 1014, 2457, 2517, 2580], 'R.F.': [738, 969, 1015, 2387, 2458, 2518, 2581, 3128], 'Hammer': [739, 970, 1016, 2459, 2519], 'R.E.': [740, 971, 1017, 2460, 2520], 'van': [741, 972, 1018, 2461, 2521], 'den': [742, 973, 1019, 2462, 2522], 'Berg': [743, 974, 1020, 2463, 2523], 'T.K.': [744, 975, 1021, 2464, 2524], 'Missler': [745, 976, 1022, 2465, 2525], 'Geuze': [747, 978, 1024, 2467, 2527], 'H.J.': [748, 979, 1025, 2468, 2528], '2000;': [752, 983, 1029, 1125, 2472, 2532, 2745], '287:': [753, 984, 1030, 2473, 2533], '864-869Crossref': [754, 985, 1031, 2474, 2534], '(984)': [757, 988, 1034, 2477, 2537], 'addition': [761, 1968, 2023, 4147], '(with': [764], 'alternatively': [766], 'spliced': [767], 'variants,': [768], 'Munc18-1a': [769], 'Munc18-1b),': [771], 'Munc18-3': [774, 1504], 'isoforms': [775, 2337], 'have': [776, 1636, 1900, 2670, 2715, 3450], 'been': [778, 896, 1095, 1217, 1390, 1417, 1510, 1628, 1637, 2712, 3184, 3230, 3248, 3312, 3823], 'identified': [779, 1096, 1218, 1638, 2346], '(7Hata': [780, 871, 1311], 'Y.': [781, 813, 872, 1139, 1267, 1275, 1312, 2759, 3203, 3327, 3335, 3385], 'Biol.': [785, 821, 876, 1123, 1249, 1281, 1316, 1544, 1700, 1767, 1795, 2392, 2743, 2795, 2896, 2976, 3060, 3274, 3291, 3341, 3368, 3426, 3488, 3534, 3837, 3907], 'Chem.': [786, 822, 877, 1124, 1282, 1317, 1545, 1768, 1796, 2744, 2796, 2897, 2977, 3061, 3292, 3342, 3489, 3535], '1995;': [787, 823, 878, 1318], '270:': [788, 824, 879, 1319], '13022-13028Abstract': [789, 880, 1320], '(167)': [797, 888, 1328], '8Katagiri': [800], 'Terasaki': [802], 'Murata': [804], 'Ishihara': [806], 'Ogihara': [808], 'Inukai': [810], 'K.': [811, 1189, 1235, 1332, 3260], 'Fukushima': [812], 'Anai': [814], 'Kikuchi': [816], 'Miyazaki': [818], '4963-4966Abstract': [825], '(69)': [833], '9Halachmi': [836], 'N.': [837, 1271, 1367, 1457, 1474, 2541, 3331, 3357, 3826, 3896], 'Lev': [838], 'Z.': [839], 'Neurochem.': [841], '1996;': [842, 1207, 1350, 1871], '66:': [843], '889-897Crossref': [844], '(123)': [847], 'Munc18-2,': [850, 4145], 'named': [852], 'Munc18b': [853], 'or': [854, 1839, 2375, 3553, 3649, 4177, 4268], 'muSec1': [855], 'ubiquitously': [857, 1507], 'Sec1),': [858], 'showing': [865], '63%': [866], 'amino': [867, 3164], 'acid': [868, 3165], 'sequence': [869], 'identity': [870, 3162], 'Scholar).The': [890, 3916], '67-kDa': [891], 'hydrophilic': [892], 'shown': [897, 1391, 1629, 3452], 'be': [899, 1166, 1513, 2048, 2244, 2819, 3025, 3111, 4007, 4093, 4250], 'necessary': [900], 'not': [901, 2659, 3855, 4249], 'vesicle': [904, 3038, 4039, 4238, 4368], 'docking': [909, 4305], '(10Burgoyne': [916, 2680], 'R.D.': [917, 1061, 1916, 2681], 'Barclay': [918, 1917, 2682], 'J.W.': [919, 1918, 2683], 'Ciufo': [920, 1923, 2684], 'L.F.': [921, 1924, 2685], 'Graham': [922, 1927, 2686], 'M.E.': [923, 1928, 2687], 'Handley': [924, 2688], 'M.T.': [925, 2689], 'Morgan': [926, 2690], 'A.': [927, 1038, 1107, 1455, 1467, 1476, 1488, 1566, 1914, 2691, 2727, 2892, 2972, 3056, 3285, 3391, 3625, 3766], 'Ann.': [928, 2692], 'N.Y.': [929, 2693], '1152:': [933, 2697], '76-86Crossref': [934, 2698], '(42)': [937, 2701], 'Indeed,': [940, 4086], 'absence': [943, 2497, 3645, 3859, 4320], 'cells,': [948, 1400, 1407, 2208, 3322], 'neither': [949], 'nor': [951], 'spontaneous': [952, 2500], 'operate': [955], 'besides': [992], 'reported': [994, 1418], 'positive': [995, 2675, 2719, 2953, 3467], 'effect': [996, 2954, 3019, 4191, 4328], 'regulated': [1000, 1957, 1974, 2170, 2378, 2631, 2678, 3112, 3239, 3447, 3945, 4237], '11Tomas': [1037, 3765], 'Meda': [1039, 3626, 3767], 'P.': [1040, 1147, 1478, 2407, 2767, 3627, 3768], 'Regazzi': [1041, 3628, 3769], 'Pessin': [1043, 3630, 3771], 'Halban': [1045, 3621, 3632, 3773], 'P.A.': [1046, 3633, 3774], 'Traffic.': [1047, 3634, 3775], '9:': [1049, 1718, 3636, 3777], '813-832Crossref': [1050, 3637, 3778], '(50)': [1053, 3640, 3781], '12Fisher': [1056], 'R.J.': [1057], 'Pevsner': [1058], 'Burgoyne': [1060, 1915], '2001;': [1063, 1701, 1797, 1857, 2598, 3536], '291:': [1064], '875-878Crossref': [1065], '(172)': [1068], '13Schütz': [1071], 'D.': [1072, 1080, 1712, 1864], 'Zilly': [1073], 'F.': [1074, 1463, 1470], 'Jahn': [1077], 'Bruns': [1079], 'Eur.': [1081, 1204, 1347, 2548], 'Neurosci.': [1083, 1856, 2550, 3132], '2005;': [1084, 1932, 3293, 3370, 3395, 3839, 3909], '21:': [1085, 1858, 2414], '2419-2432Crossref': [1086], '(47)': [1089], 'Scholar),': [1091, 1558, 1581, 3783], 'negative': [1099, 2673, 3018, 4327], 'secretion': [1103, 1589, 1748, 1959, 1980, 2258, 2353, 2575, 2966, 3021, 3196, 3256, 3863, 4001, 4157], '(14Zhang': [1104, 2724], 'W.': [1105, 2725], 'Efanov': [1106, 2726], 'Yang': [1108, 1142, 1784, 2728, 2762, 3523], 'S.N.': [1109, 1785, 2729, 3524], 'Fried': [1110, 1760, 2730, 2788, 3481], 'Kolare': [1112, 2732], 'S.': [1113, 1117, 1193, 1195, 1201, 1241, 1243, 1336, 1338, 1344, 1359, 1486, 1536, 1844, 1848, 2733, 2737, 2932, 2996, 3080, 3266, 3268, 3424], 'Brown': [1114, 2734], 'Zaitsev': [1116, 2736], '275:': [1126, 2746], '41521-41527Abstract': [1127, 2747], '(78)': [1135, 2755], '15Dong': [1138, 2758], 'Wan': [1140, 2760], 'Q.': [1141, 2761], 'X.': [1143, 2763, 3205], 'Bai': [1144, 2764], 'Xu': [1146, 2766], 'Biochem.': [1148, 1206, 1349, 1572, 1662, 1929, 2768], 'Biophys.': [1149, 1573, 1663, 2769, 3393], 'Res.': [1150, 1870, 2770], 'Commun.': [1151, 2771], '2007;': [1152, 1251, 2772, 2898, 2944, 2978, 3008, 3062, 3092, 3133, 3276], '360:': [1153, 2773], '609-614Crossref': [1154, 2774], '(11)': [1157, 2777], 'Still,': [1160], 'primarily': [1163], 'considered': [1164], 'wider': [1176], 'tissue': [1177], 'expression': [1178, 2290, 4246], 'profile.': [1179], 'For': [1180, 1823, 2704], 'instance,': [1181], 'prominent': [1184, 1228], 'epithelial': [1186, 3233], 'cells': [1187, 1564, 2564, 2617, 2851, 3175, 3325, 3849, 3890, 3996], '(16Riento': [1188], 'Jäntti': [1190, 1333], 'Jansson': [1192, 1335], 'Hielm': [1194, 1337], 'Lehtonen': [1196, 1339], 'E.': [1197, 1340, 1593, 1612, 1852, 2004, 2594], 'Ehnholm': [1198, 1341], 'C.': [1199, 1342, 1435, 1459, 1461, 1765, 1793, 2409, 2793, 2888, 2968, 3052, 3486, 3532], 'Keränen': [1200, 1242, 1343, 3267], 'Olkkonen': [1202, 1246, 1276, 1345, 3271, 3336], 'V.M.': [1203, 1247, 1277, 1346, 3272, 3337], '239:': [1208, 1351], '638-646Crossref': [1209, 1352], '(56)': [1212, 1355], 'Scholar)': [1214], 'binding': [1221, 1305, 2859, 2875, 3104], 'partner': [1222, 1516], 'Cab45,': [1224], 'Ca2+-binding': [1226], 'acini': [1231], '(17Lam': [1232, 3257], 'P.P.': [1233, 1273, 3258, 3333], 'Hyvärinen': [1234, 3259], 'Kauppi': [1236, 3261], 'Cosen-Binker': [1238, 3263], 'Laitinen': [1240, 3265], 'Gaisano': [1244, 1278, 3216, 3269, 3338, 3417], 'H.Y.': [1245, 1279, 3217, 3270, 3339, 3418], 'Mol.': [1248, 1698, 3273, 3425], '18:': [1252, 3277], '2473-2480Crossref': [1253, 3278], 'Recently': [1257], 'Cab45/Munc18-2': [1258], 'was': [1259, 2320, 2426, 3738, 3893, 3986, 3997, 4060], 'detected': [1261, 3185], 'endocrine': [1264, 1944, 2192], '(18Zhang': [1266, 3326], 'Kang': [1268, 3328], 'Y.H.': [1269, 3329], 'Chang': [1270, 3330], 'Lam': [1272, 3332], 'Liu': [1274, 2931, 2995, 3079, 3334], '284:': [1284, 3344], '20840-20847Abstract': [1285, 3345], '(7)': [1293, 3353], 'exhibits': [1297], 'selectivity': [1301], '2,': [1308], '3': [1310, 2340, 3181], '16Riento': [1331], '19Martin-Verdeaux': [1358], 'Pombo': [1360], 'I.': [1361, 2928, 2934, 2992, 2998, 3076, 3082], 'Iannascoli': [1362], 'Roa': [1364], 'Varin-Blank': [1366], 'Rivera': [1368], 'Blank': [1370, 1479], 'U.': [1371, 1480], 'Cell': [1373, 1661, 1699, 1715, 1868, 2391], '116:': [1376], '325-334Crossref': [1377], '(108)': [1380], 'Worth': [1383], 'mentioning': [1384], 'capacity': [1396], 'mammalian': [1399], 'such': [1401, 2261], 'HeLa,': [1403], 'HEK-293,': [1404], 'HT-1080': [1406], 'mutation': [1410], 'gene': [1413, 2436], 'encoding': [1414], 'impair': [1420], 'cytotoxic': [1421], 'granule': [1422, 4025, 4077, 4165], 'cause': [1425], 'familial': [1426], 'hemophagocytic': [1427], 'lymphohistiocytosis': [1428], 'type': [1429], '5,': [1430], 'FHL-5': [1431], '(20Peng': [1432], 'R.W.': [1433], 'Guetg': [1434], 'Tigges': [1436], 'Fussenegger': [1438], 'Eng.': [1441], '2010;': [1442, 1603, 1717, 2014], '12:': [1443], '18-25Crossref': [1444], '(37)': [1447], '21Côte': [1450], 'Ménager': [1452], 'M.M.': [1453], 'Burgess': [1454], 'Mahlaoui': [1456], 'Picard': [1458], 'Schaffner': [1460], 'Al-Manjomi': [1462], 'Al-Harbi': [1464], 'Alangari': [1466], 'Le': [1468], 'Deist': [1469], 'Gennery': [1471], 'A.R.': [1472], 'Prince': [1473], 'Cariou': [1475], 'Nitschke': [1477], 'El-Ghazali': [1481], 'Ménasché': [1483], 'Latour': [1485], 'Fischer': [1487], 'de': [1489, 2584], 'Saint': [1490], 'Basile': [1491], 'Clin.': [1494], 'Invest.': [1495], '119:': [1497], '3765-3773Crossref': [1498], '(277)': [1501], 'expressed': [1506, 3456], 'functional': [1515, 3647], '4': [1519], 'regulation': [1522], 'insulin-stimulated': [1524], 'translocation': [1525, 3509, 3601], 'GLUT-4': [1527], '3T3-L1': [1529], 'adipocytes': [1530], '(22Tellam': [1531], 'Macaulay': [1533], 'S.L.': [1534], 'McIntosh': [1535], 'Hewish': [1537], 'D.R.': [1538], 'Ward': [1539], 'C.W.': [1540], 'James': [1541], 'D.E.': [1542], '1997;': [1546], '272:': [1547], '6179-6186Abstract': [1548], '(184)': [1556], 'amylase': [1559, 3255], 'from': [1561, 1749, 2044, 2080, 2325, 2487, 2565, 3510, 3850, 3864, 3882], 'parotid': [1562], 'acinar': [1563], '(23Imai': [1565], 'Nashida': [1567, 3286], 'Shimomura': [1569, 3288], 'Arch.': [1571], '2004;': [1574, 1769, 2551, 2797, 3490], '422:': [1575], '175-182Crossref': [1576], '(35)': [1579], 'second': [1585, 1886, 4139], '(24Jewell': [1590], 'J.L.': [1591, 1811, 2002], 'Oh': [1592, 2003], 'Thurmond': [1594, 1613, 2005], 'D.C.': [1595, 1614, 2006], 'Regul.': [1599, 2010], 'Integr.': [1600, 2011], 'Comp.': [1601, 2012], '298:': [1604, 2015], '517-531Crossref': [1605], '(0)': [1608], '25Oh': [1611], 'Diabetes.': [1615], '58:': [1617], '1165-1174Crossref': [1618], '(43)': [1621], 'Scholar).Phosphorylation': [1623, 3435], 'affect': [1631, 2113], 'exocytosis.': [1632, 2133, 4335], 'Two': [1633], 'kinases': [1634], 'modify': [1640], 'cyclin-dependent': [1646], '5': [1648], '(Cdk5)': [1649], 'C': [1653], '(PKC)': [1654], '(26Snyder': [1655], 'D.A.': [1656], 'Kelly': [1657], 'M.L.': [1658], 'Woodbury': [1659], 'D.J.': [1660], '2006;': [1664, 1815], '45:': [1665, 3220], '111-123Crossref': [1666], 'Cdk5': [1670, 1731, 1826, 3504, 3648, 3675, 3706, 4265, 4322], 'small': [1673, 2571], 'serine/threonine': [1674], 'plays': [1677, 3439], 'pivotal': [1679], 'role': [1680, 1904, 2964, 3442], 'many,': [1682], 'particular': [1684], 'neuronal,': [1685], 'processes': [1686], 'phosphorylating': [1688], 'several': [1689, 1899, 2238], 'substrates': [1691], '(27Dhavan': [1692], 'Tsai': [1694, 1853], 'L.H.': [1695, 1854], 'Nat.': [1696], '2:': [1702, 1872], '749-759Crossref': [1703], '(936)': [1706], '28Lalioti': [1709], 'V.': [1710], 'Pulido': [1711], 'Sandoval': [1713], 'I.V.': [1714], 'Cycle.': [1716], '284-311Crossref': [1719], '(54)': [1722, 3224], 'Nevertheless,': [1725, 2194], 'emerging': [1726], 'evidence': [1727], 'vital': [1734], 'non-neuronal': [1736, 2225], 'tissues,': [1737, 3234], 'example': [1739, 2189, 3763], 'during': [1740, 3037, 3611, 4137, 4168], 'muscle': [1741], 'development,': [1742], 'wound': [1743], 'healing,': [1744], '(29Lilja': [1752, 3473], 'Johansson': [1754, 2782, 3475], 'J.U.': [1755, 2783, 3476], 'Gromada': [1756, 2784, 3477], 'Mandic': [1758, 2786, 3479], 'S.A.': [1759, 2787, 3480], 'Bark': [1764, 1792, 2792, 3485, 3531], '279:': [1770, 2798, 3491], '29534-29541Abstract': [1771, 2799, 3492], '(62)': [1779, 2807, 3500], '30Lilja': [1782], 'Webb': [1786, 3525], 'D.L.': [1787, 3526], '276:': [1798, 3537], '34199-34205Abstract': [1799, 3538], '(88)': [1807, 3546], '31Rosales': [1810], 'Lee': [1812], 'K.Y.': [1813], 'BioEssays.': [1814], '1023-1034Crossref': [1817], '(98)': [1820], 'activation,': [1825], 'dependent': [1828], 'upon': [1829], 'association': [1830], 'one': [1832, 2245, 4217], 'regulatory': [1836, 1903, 2647, 4226], 'subunits,': [1837], 'p35': [1838, 4274], 'p39': [1840, 4341], '(32Ko': [1841], 'Humbert': [1843], 'Bronson': [1845], 'R.T.': [1846], 'Takahashi': [1847], 'Kulkarni': [1849], 'Li': [1851], '6758-6771Crossref': [1859], '33Tang': [1863], 'Wang': [1865, 3413], 'Prog.': [1867], 'Cycle': [1869], '205-216Crossref': [1873], '(75)': [1876], 'PKC,': [1879], 'which': [1880, 1898, 2176, 2328, 3159, 4308], 'part': [1882, 2879], 'diacylglycerol': [1885], 'messenger': [1887], 'pathway,': [1888], 'exists': [1893, 2854], 'many': [1895, 4230], 'isoforms,': [1896], 'established': [1902], 'physiological': [1907, 2053], 'steps': [1908, 3924, 4231], '(34Morgan': [1913], 'Craig': [1919], 'T.J.': [1920], 'Prescott': [1921], 'G.R.': [1922], 'Evans': [1925], 'G.J.': [1926], 'Soc.': [1930], 'Trans.': [1931], '33:': [1933], '1341-1344Crossref': [1934], '(80)': [1937], 'Despite': [1940, 3717], 'fact': [1942, 4011], 'synapses,': [1956], 'may': [1960, 4006, 4074, 4248], 'require': [1961], 'versatility.': [1963], 'Primary': [1964], 'have,': [1966], 'phases': [1977, 2255, 2828], 'displaying': [1981], 'kinetics': [1983, 2926], 'compared': [1984, 3887, 4353], 'initial': [1987], '(35Henquin': [1990], 'J.C.': [1991], 'Diabetologia.': [1992, 3218], '52:': [1994], '739-751Crossref': [1995], '(350)': [1998], '36Jewell': [2001], 'R517-R531Crossref': [2016], '(90)': [2019], 'maintaining': [2025], 'normal': [2027], 'basal': [2028], 'magnitude': [2040], 'released': [2042, 3736, 3753, 4167], 'need': [2046], 'precisely': [2049], 'tailored': [2050], 'conditions.': [2054], 'explore': [2056], 'transmission,': [2064], 'closely': [2069], 'related': [2070], 'contribute': [2073, 2165], 'adaptability': [2076, 2265], 'β-cells,': [2081, 2707, 3315, 3615, 3989], 'their': [2084, 2093, 2119, 2159, 2298, 4081], 'presence,': [2085], 'abundance,': [2086], 'intracellular': [2088, 2383, 4029], 'well': [2091], 'influence': [2094], 'secretion.': [2104, 3448, 3732, 3792, 4215], 'could': [2106, 2612, 2816, 4092], 'demonstrate': [2107], 'depending': [2117], 'status,': [2121, 2161], 'they': [2122], 'localization': [2126, 3561], 'control': [2128, 2281, 3251, 3995, 4351], 'now': [2135], 'suggest': [2136], 'fine-tuning': [2141], 'partly': [2149, 3121], 'relies': [2150], 'variants': [2157], 'these': [2163, 2488, 2812, 3575, 3666], 'variations': [2164], 'versatility': [2168], 'release.DISCUSSIONThe': [2172], 'main': [2178], 'produce': [2182], 'insulin,': [2185], 'classic': [2188], 'cell.': [2193], 'full': [2198], 'repertoire': [2199], 'SNARE-regulating': [2203], 'found': [2205], 'including': [2209], 'protein.': [2213, 2842], 'previously': [2221, 3451], 'implicated': [2222], 'exocytosis;': [2226], 'example,': [2228, 2705], 'hypothesize': [2231], 'operators': [2236], 'pathways': [2240, 2385, 3749], 'might': [2243], 'underlying': [2248], 'reasons': [2249], 'why': [2250], 'this': [2251, 4126, 4212, 4367], 'cell': [2252, 2308, 3809], 'manages': [2253], 'multiple': [2254], 'demonstrates': [2260], 'diversity': [2263], 'response.': [2269, 4199], 'This': [2270, 2611, 2911, 2952, 4005, 4067, 4142, 4200, 4370], 'attribute': [2273], 'important': [2274, 3441, 4161], 'tightly': [2280], 'body.We': [2286], 'first': [2287, 3976], 'abundance': [2292], 'endogenous': [2294, 4205], 'mRNAs': [2296], 'corresponding': [2299], 'partners': [2301], 'islets,': [2303], 'brain,': [2304], 'insulinoma': [2307], 'line': [2309], 'MIN6.': [2310], 'results': [2312, 2813], 'showed': [2313], 'relative': [2316], 'level': [2317, 4247], 'surprisingly': [2321], 'islets': [2324], 'ob/ob': [2326], 'mice,': [2327], 'average': [2330], 'contain': [2331], '90–95%': [2332], 'β-cells.': [2333, 3696, 3716, 3983], 'matching': [2335], '1': [2338, 2862, 2882, 3156], 'were': [2341, 2491, 3517, 3577, 3727], 'expressed.Sec1/Munc18': [2343], 'originally': [2345], 'trafficking': [2351, 2384, 3445], 'yeast,': [2355], 'among': [2359], 'organisms.': [2360], 'Null': [2361], 'mutations': [2362], 'genes': [2366], 'variety': [2369], 'species': [2371], 'resulted': [2372], 'disruption': [2374, 2431], 'disturbances': [2376], 'and/or': [2381], 'specific': [2382], '(42Toonen': [2386], 'Verhage': [2388, 2544, 2595, 3129, 3366, 3835, 3905], 'Trends': [2390, 3131], '13:': [2394], '177-186Abstract': [2395], '(200)': [2403], '43Novick': [2406], 'Field': [2408], 'Schekman': [2410], '1980;': [2413], '205-215Abstract': [2415], '(1249)': [2421], 'Particularly': [2424], 'remarkable': [2425], 'finding': [2428], 'targeted': [2430], 'mouse': [2434, 2489], 'produced': [2437], 'mutant': [2439, 3708, 4267], 'died': [2441], 'shortly': [2442], 'after': [2443, 3671], 'birth': [2444], 'brain': [2482], 'development': [2483], 'appeared': [2484, 3875], 'normal,': [2485], 'embryos': [2486, 2568], 'mutants': [2490, 3555, 3667, 3853, 3886], 'paralyzed': [2492], 'due': [2493], 'complete': [2496, 3858], '44Korteweg': [2540], 'Burbach': [2546, 3364, 3833, 3903], 'J.P.': [2547, 3365, 3834, 3904], '19:': [2552], '2944-2952Crossref': [2553], '(6)': [2556], 'analyses': [2560], 'neuroendocrine': [2562], 'chromaffin': [2563], 'null': [2567, 3852], 'significant': [2573, 4190], 'catecholamines': [2577], '(45Voets': [2578], 'Brian': [2582], 'E.C.': [2583], 'Wit': [2585], 'Moser': [2587], 'Rettig': [2589], 'Neher': [2593], 'Neuron.': [2597], '31:': [2599], '581-591Abstract': [2600], '(297)': [2608], 'indicate': [2613], 'some': [2615, 2849], 'possess': [2618], 'Munc18-1-dependent': [2621], 'pathway': [2623], 'yet': [2626], 'redundant': [2627], 'bypass': [2628], 'route,': [2629], 'allowing': [2630], 'occur': [2634], 'Munc18-1-independent': [2637, 2855], 'way.Despite': [2638], 'being': [2639], 'subject': [2641], 'intense': [2643], 'studies,': [2644], 'precise': [2646], 'roles': [2648, 2676, 2838], 'sites': [2651, 3652], 'action': [2653], 'entirely': [2660], 'elucidated.': [2661], 'Several': [2662], 'studies': [2663, 3805], 'organisms': [2669], 'proposed': [2713], 'inhibitory': [2717, 2963], 'effects': [2720, 3961], '29Lilja': [2780], 'Inconsistency': [2810], 'course': [2818], 'experimental': [2824, 4261], 'techniques': [2825], 'measuring': [2826], 'cascade': [2833, 3928], 'thereby': [2835, 3117], 'emphasizing': [2836], 'An': [2843], 'possibility': [2845], 'Munc18-1-expressing': [2850], 'there': [2852], 'pathways.': [2857], 'Besides': [2858], 'monomeric': [2860], 'closed': [2865], 'conformation,': [2866], 'recent': [2867, 3618], 'findings': [2868, 3619, 3797, 4376], 'capable': [2873, 4302], 'N-terminal': [2878], 'open': [2885], 'configuration': [2886], '(46Rickman': [2887, 2967, 3051], 'Medine': [2889, 2969, 3053], 'C.N.': [2890, 2970, 3054], 'Bergmann': [2891, 2971, 3055], 'Duncan': [2893, 2973, 3057], 'R.R.': [2894, 2974, 3058], '282:': [2899, 2979, 3063], '12097-12103Abstract': [2900, 2980, 3064], '(104)': [2908, 2988, 3072], 'direct': [2912], 'interaction': [2913], 'assembled': [2918], 'promotes': [2921], 'pore': [2925], '(47Dulubova': [2927], 'Khvotchev': [2929, 2993, 3077], 'Huryeva': [2933, 2997, 3081], 'Rizo': [2937, 3001, 3085], '104:': [2945, 3009, 3093], '2697-2702Crossref': [2946, 3010, 3094], '(254)': [2949, 3013, 3097], 'contradicts': [2955], 'traditional': [2957], 'theory': [2958], 'playing': [2961], '47Dulubova': [2991, 3075], 'believed': [3023, 3109], 'mediated': [3026], 'through': [3027], 'formation': [3029], 'affinity': [3033], 'syntaxin-1/Munc18-1': [3034], 'interaction,': [3035], 'likely': [3036, 4159], 'docking,': [3039, 4026], 'preventing': [3042], 'syntaxin-1': [3043, 4016], 'assembly': [3045], 'into': [3046], 'trimeric': [3048], 'Transitions': [3100], 'modes': [3105], 'dynamic': [3114], 'phosphorylation/dephosphorylation,': [3115], 'contributes': [3122], 'ambiguity': [3126], '(48Toonen': [3127], '30:': [3134], '564-572Abstract': [3135], '(147)': [3143], 'Scholar).Munc18-1': [3145], 'bind': [3150], 'target': [3153], '3,': [3158], '64%': [3161], 'structure': [3166], 'domains.': [3171], 'Interestingly,': [3172, 3643], 'HIT-T15': [3174], 'cytoplasm,': [3188], 'functioning': [3189], 'modulator': [3193], 'channel': [3200], '(49Kang': [3202], 'Huang': [3204], 'Pasyk': [3206], 'E.A.': [3207], 'Ji': [3208], 'Holz': [3210], 'G.G.': [3211], 'Wheeler': [3212], 'M.B.': [3213], 'Tsushima': [3214], 'R.G.': [3215], '2002;': [3219], '231-241Crossref': [3221], 'mostly': [3229], 'studied': [3231, 4258], 'where': [3235, 3245, 3815, 4377], 'it': [3236, 3246, 3798], 'controls': [3237], 'apical': [3238], 'acini,': [3244], 'Slp4a/granuphilin-syntaxin': [3252], '50Fukuda': [3282], 'Imai': [3284], '280:': [3294], '39175-39184Abstract': [3295], '(46)': [3303], 'Coexpression': [3306], 'confirmed': [3313], 'somatotrophs': [3316], 'anterior': [3319], 'pituitary,': [3320], 'mast': [3321], 'PC12': [3324], '52Korteweg': [3356], 'Thompson': [3360, 3829, 3899], 'Roubos': [3362, 3831, 3901], 'E.W.': [3363, 3832, 3902], '97:': [3371, 3840, 3910], '445-455Crossref': [3372, 3841, 3911], '(18)': [3375, 3844, 3914], '53Nigam': [3378], 'Sepulveda': [3380], 'Tuvim': [3382], 'Petrova': [3384], 'Adachi': [3386], 'Dickey': [3388], 'B.F.': [3389], 'Agrawal': [3390], 'Biochim.': [3392], 'Acta.': [3394], '1728:': [3396], '77-83Crossref': [3397], '(10)': [3400], '54Han': [3403], 'Jiang': [3405], 'Han': [3407], 'G.A.': [3408], 'Malintan': [3409], 'N.T.': [3410], 'Xie': [3411], 'Tse': [3415], 'F.W.': [3416], 'Collins': [3419], 'B.M.': [3420], 'Meunier': [3421], 'F.A.': [3422], 'Sugita': [3423], '20:': [3429], '4962-4975Crossref': [3430], '(57)': [3433], 'and,': [3460], 'together': [3461, 4014], 'Cdk5/p39,': [3463], 'acts': [3464], 'induced': [3470], 'membrane-bound': [3511, 3669, 3693], 'cytosolic': [3513, 3710], 'fractions': [3514, 3610], 'when': [3515, 3891], '(30Lilja': [3521], 'investigate': [3550], 'WT': [3552, 3605, 3703, 3889, 3964, 4175, 4270, 4299, 4344], 'changed': [3560], 'cellular': [3566], 'stimulation,': [3567], 'transiently': [3570], 'transfected': [3571], 'MIN6': [3572], 'Importantly,': [3574], 'experiments': [3576], 'performed': [3578], 'using': [3579, 3948], 'epitope-tagged': [3580], 'constructs,': [3582], 'antibodies': [3585], 'usually': [3586], 'degree': [3590], 'cross-reactivity': [3592], 'isoforms.': [3597], 'observed': [3599, 3824], 'stimulation': [3613], 'consistent': [3616], 'co-workers': [3623], '(11Tomas': [3624], 'PKC': [3650, 3677], 'sequestered': [3653], 'already': [3661], 'under': [3662], 'unstimulatory': [3663], 'conditions,': [3664], 'remained': [3668, 3709], 'Obviously,': [3673], 'required': [3680, 3998, 4033], 'correct': [3683], 'cycling': [3684], 'cytosolic-': [3691], 'state': [3694], 'On': [3697, 4045, 4336], 'hand,': [3700, 4048, 4339], 'unstimulated': [3713], 'difference': [3719], 'able': [3728], 'modest': [3739], 'reproducible.': [3741], 'It': [3742], 'possible': [3744], 'trigger': [3746, 4000], 'signaling': [3748], 'further': [3751, 4095, 4124], 'enhance': [3752], 'hGH': [3754], 'adding': [3756, 4340], 'mixture': [3758], 'secretagogues': [3760], '(see': [3761], 'Ref.': [3764], 'chose': [3786], 'look': [3788], 'glucose-dependent': [3791], 'light': [3794], 'our': [3796, 4260, 4374], 'interest': [3801], 'compare': [3803], 'made': [3806], 'another': [3808], 'type,': [3810], 'namely': [3811], 'pituitary': [3813, 3848], 'somatotrophs,': [3814], 'co-existence': [3816], '(52Korteweg': [3825, 3895], 'Anterior': [3847], 'did': [3854], 'peptide': [3862], 'large': [3865, 3871], 'dense': [3866, 3872], 'vesicles.': [3868, 4004], 'reside': [3877], 'larger': [3880], 'distance': [3881], 'absent': [3894], 'involved': [3920, 4228], 'early': [3923], 'close': [3933], 'fusion.': [3938, 4287], 'investigated': [3940], 'slow': [3952], 'carefully': [3958], 'evaluated': [3959], 'mutated': [3967], 'templates': [3968], 'rate': [3971, 4331], 'amplitude': [3973, 4333], 'seconds': [3977], 'Ca2+-triggered': [3979], 'When': [3984], 'overexpressed': [3987], 'higher': [3991, 4028, 4315], '[Ca2+]i': [3992], 'than': [3993], 'release-competent': [4003], 'explained': [4008], 'forms': [4017], 'engaged': [4022], 'levels': [4031, 4352], 'augmenting': [4035], 'transition': [4037], 'membrane.': [4044], 'shifted': [4051], 'so': [4055], 'initiated': [4062], 'concentrations.': [4066], 'suggests': [4068, 4143, 4201], 'support': [4075], 'populations': [4078], 'content': [4082], 'divided': [4094], 'components': [4098], 'demonstrating': [4099], 'kinetics,': [4102], 'rate1': [4103], 'rate2,': [4105], 'amplitudes,': [4109], 'amp1': [4110], 'amp2.': [4112, 4169], 'Both': [4113], 'coexpression': [4114], 'single': [4120, 4355], 'introduction': [4121], 'supported': [4125], 'significantly': [4128], 'increasing': [4129, 4362], 'number': [4131], 'releasable': [4133], '(amp2)': [4135], 'exocytosed': [4136], 'phase.': [4141], 'assisting': [4149], '(amp1),': [4158], 'refilling': [4163], 'pool': [4166], 'Partial': [4170], 'silencing': [4171], '(reduced': [4181], '∼10–15%),': [4183], 'quantified': [4184], 'Western': [4186], 'blot,': [4187], 'had': [4188], 'no': [4189], 'remaining': [4204], 'still': [4208, 4301], 'sufficient': [4209], 'manage': [4211], 'should': [4218], 'bear': [4219], 'mind': [4221], 'preceding': [4232], 'fusion,': [4239], 'partial': [4242], 'down-regulation': [4243], 'rate-limiting': [4252], 'step': [4257], 'set': [4262], 'up.': [4263], 'combination': [4272], 'lowered': [4275], 'sensitivity,': [4278, 4317], 'i.e.': [4279], 'increased': [4280], '“threshold”': [4283], 'non-phosphorylated': [4289], 'form': [4290], 'is,': [4295], 'similar': [4296, 4372], 'template,': [4300], 'stably': [4304], 'granules,': [4307], 'followed': [4310], 'leads': [4324], 'restored': [4345], 'WT,': [4359], 'apparently': [4361], 'probability': [4365], 'pool.': [4369], 'earlier': [4375], 'Cdk5/p39': [4378], 'facilitated': [4379]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1966587178', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-13T16:08:35.032765', 'created_date': '2016-06-24'}