Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1966491096', 'doi': 'https://doi.org/10.1002/jcp.24972', 'title': 'Phosphorylation of Runx2, induced by cyclic mechanical tension via ERK1/2 pathway, contributes to osteodifferentiation of human periodontal ligament fibroblasts', 'display_name': 'Phosphorylation of Runx2, induced by cyclic mechanical tension via ERK1/2 pathway, contributes to osteodifferentiation of human periodontal ligament fibroblasts', 'publication_year': 2015, 'publication_date': '2015-03-05', 'ids': {'openalex': 'https://openalex.org/W1966491096', 'doi': 'https://doi.org/10.1002/jcp.24972', 'mag': '1966491096', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25740112'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jcp.24972', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S43643205', 'display_name': 'Journal of Cellular Physiology', 'issn_l': '0021-9541', 'issn': ['0021-9541', '1097-4652'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101812966', 'display_name': 'Dapeng Ren', 'orcid': 'https://orcid.org/0000-0001-6844-1863'}, 'institutions': [{'id': 'https://openalex.org/I154099455', 'display_name': 'Shandong University', 'ror': 'https://ror.org/0207yh398', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I154099455']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Dapeng Ren', 'raw_affiliation_strings': ['Department of Orthodontics, Shandong University, Jinan, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Orthodontics, Shandong University, Jinan, China.', 'institution_ids': ['https://openalex.org/I154099455']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051069528', 'display_name': 'Fulan Wei', 'orcid': 'https://orcid.org/0000-0001-6827-8293'}, 'institutions': [{'id': 'https://openalex.org/I108688024', 'display_name': 'Qingdao University', 'ror': 'https://ror.org/021cj6z65', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I108688024']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Fulan Wei', 'raw_affiliation_strings': ['Department of Orthodontics, Qingdao Municipal Hospital, Qingdao University, the 4th Military Medical University, Qingdao, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Orthodontics, Qingdao Municipal Hospital, Qingdao University, the 4th Military Medical University, Qingdao, China.', 'institution_ids': ['https://openalex.org/I108688024']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100753903', 'display_name': 'Lihua Hu', 'orcid': 'https://orcid.org/0000-0002-4996-3372'}, 'institutions': [{'id': 'https://openalex.org/I108688024', 'display_name': 'Qingdao University', 'ror': 'https://ror.org/021cj6z65', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I108688024']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Lihua Hu', 'raw_affiliation_strings': ['Department of Orthodontics, Qingdao Municipal Hospital, Qingdao University, the 4th Military Medical University, Qingdao, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Orthodontics, Qingdao Municipal Hospital, Qingdao University, the 4th Military Medical University, Qingdao, China.', 'institution_ids': ['https://openalex.org/I108688024']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5105141201', 'display_name': 'Shuangyan Yang', 'orcid': 'https://orcid.org/0000-0003-0790-2173'}, 'institutions': [{'id': 'https://openalex.org/I108688024', 'display_name': 'Qingdao University', 'ror': 'https://ror.org/021cj6z65', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I108688024']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shuangyan Yang', 'raw_affiliation_strings': ['Department of Orthodontics, Qingdao Municipal Hospital, Qingdao University, the 4th Military Medical University, Qingdao, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Orthodontics, Qingdao Municipal Hospital, Qingdao University, the 4th Military Medical University, Qingdao, China.', 'institution_ids': ['https://openalex.org/I108688024']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100661179', 'display_name': 'Chunling Wang', 'orcid': 'https://orcid.org/0000-0002-4187-6098'}, 'institutions': [{'id': 'https://openalex.org/I154099455', 'display_name': 'Shandong University', 'ror': 'https://ror.org/0207yh398', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I154099455']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chunling Wang', 'raw_affiliation_strings': ['Department of Orthodontics, Shandong University, Jinan, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Orthodontics, Shandong University, Jinan, China.', 'institution_ids': ['https://openalex.org/I154099455']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5019701501', 'display_name': 'Xiao Yuan', 'orcid': 'https://orcid.org/0000-0003-3590-1805'}, 'institutions': [{'id': 'https://openalex.org/I108688024', 'display_name': 'Qingdao University', 'ror': 'https://ror.org/021cj6z65', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I108688024']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiao Yuan', 'raw_affiliation_strings': ['Department of Orthodontics, Qingdao Municipal Hospital, Qingdao University, the 4th Military Medical University, Qingdao, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Orthodontics, Qingdao Municipal Hospital, Qingdao University, the 4th Military Medical University, Qingdao, China.', 'institution_ids': ['https://openalex.org/I108688024']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4940, 'currency': 'USD', 'value_usd': 4940, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.643, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 40, 'citation_normalized_percentile': {'value': 0.856575, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '230', 'issue': '10', 'first_page': '2426', 'last_page': '2436'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11219', 'display_name': 'Bone Metabolism and Diseases', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11219', 'display_name': 'Bone Metabolism and Diseases', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12030', 'display_name': 'S100 Proteins and Annexins', 'score': 0.996, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10620', 'display_name': 'Protease and Inhibitor Mechanisms', 'score': 0.9958, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/runx2', 'display_name': 'RUNX2', 'score': 0.9787433}, {'id': 'https://openalex.org/keywords/periodontal-fiber', 'display_name': 'Periodontal fiber', 'score': 0.5776964}], 'concepts': [{'id': 'https://openalex.org/C2776363554', 'wikidata': 'https://www.wikidata.org/wiki/Q14907085', 'display_name': 'RUNX2', 'level': 4, 'score': 0.9787433}, {'id': 'https://openalex.org/C2778260815', 'wikidata': 'https://www.wikidata.org/wiki/Q917177', 'display_name': 'Osteoblast', 'level': 3, 'score': 0.59694445}, {'id': 'https://openalex.org/C11960822', 'wikidata': 'https://www.wikidata.org/wiki/Q242736', 'display_name': 'Phosphorylation', 'level': 2, 'score': 0.5938202}, {'id': 'https://openalex.org/C41868710', 'wikidata': 'https://www.wikidata.org/wiki/Q540092', 'display_name': 'Periodontal fiber', 'level': 2, 'score': 0.5776964}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.52017903}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.48355123}, {'id': 'https://openalex.org/C199343813', 'wikidata': 'https://www.wikidata.org/wiki/Q12128', 'display_name': 'Dentistry', 'level': 1, 'score': 0.26537484}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.24209869}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.21340457}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.16313875}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.12625986}], 'mesh': [{'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D050659', 'descriptor_name': 'Core Binding Factor Alpha 1 Subunit', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': True}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D020935', 'descriptor_name': 'MAP Kinase Signaling System', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D010513', 'descriptor_name': 'Periodontal Ligament', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050659', 'descriptor_name': 'Core Binding Factor Alpha 1 Subunit', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020935', 'descriptor_name': 'MAP Kinase Signaling System', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048052', 'descriptor_name': 'Mitogen-Activated Protein Kinase 3', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D048052', 'descriptor_name': 'Mitogen-Activated Protein Kinase 3', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010012', 'descriptor_name': 'Osteogenesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010012', 'descriptor_name': 'Osteogenesis', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D010513', 'descriptor_name': 'Periodontal Ligament', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013314', 'descriptor_name': 'Stress, Mechanical', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jcp.24972', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S43643205', 'display_name': 'Journal of Cellular Physiology', 'issn_l': '0021-9541', 'issn': ['0021-9541', '1097-4652'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25740112', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '81271140'}], 'datasets': [], 'versions': [], 'referenced_works_count': 53, 'referenced_works': ['https://openalex.org/W1968631956', 'https://openalex.org/W1970267055', 'https://openalex.org/W1970728706', 'https://openalex.org/W1971912573', 'https://openalex.org/W1976860995', 'https://openalex.org/W1985099155', 'https://openalex.org/W1987664600', 'https://openalex.org/W1992184028', 'https://openalex.org/W1993099542', 'https://openalex.org/W1994596418', 'https://openalex.org/W2001084083', 'https://openalex.org/W2010426112', 'https://openalex.org/W2010946184', 'https://openalex.org/W2013176040', 'https://openalex.org/W2013706945', 'https://openalex.org/W2019257051', 'https://openalex.org/W2024845924', 'https://openalex.org/W2027622647', 'https://openalex.org/W2030049354', 'https://openalex.org/W2032649937', 'https://openalex.org/W2039873280', 'https://openalex.org/W2043538002', 'https://openalex.org/W2052052041', 'https://openalex.org/W2062276394', 'https://openalex.org/W2068142934', 'https://openalex.org/W2068163798', 'https://openalex.org/W2068165473', 'https://openalex.org/W2069884943', 'https://openalex.org/W2071091332', 'https://openalex.org/W2079300921', 'https://openalex.org/W2080644905', 'https://openalex.org/W2084133967', 'https://openalex.org/W2084882319', 'https://openalex.org/W2085907524', 'https://openalex.org/W2090372890', 'https://openalex.org/W2095309854', 'https://openalex.org/W2096232808', 'https://openalex.org/W2106976200', 'https://openalex.org/W2108281583', 'https://openalex.org/W2113442798', 'https://openalex.org/W2113503572', 'https://openalex.org/W2122367477', 'https://openalex.org/W2123265485', 'https://openalex.org/W2126599666', 'https://openalex.org/W2131537650', 'https://openalex.org/W2131612364', 'https://openalex.org/W2136299535', 'https://openalex.org/W2143248660', 'https://openalex.org/W2147073902', 'https://openalex.org/W2153720415', 'https://openalex.org/W2157989212', 'https://openalex.org/W2168040202', 'https://openalex.org/W2168346484'], 'related_works': ['https://openalex.org/W4229334786', 'https://openalex.org/W3094260794', 'https://openalex.org/W3005242938', 'https://openalex.org/W2901317429', 'https://openalex.org/W2890741641', 'https://openalex.org/W2592449359', 'https://openalex.org/W2217100198', 'https://openalex.org/W2160248324', 'https://openalex.org/W2036570518', 'https://openalex.org/W1988944924'], 'abstract_inverted_index': {'Occlusal': [0], 'force': [1, 26], 'is': [2, 11, 200], 'an': [3], 'important': [4], 'stimulus': [5], 'for': [6, 98], 'maintaining': [7], 'periodontal': [8, 18], 'homeostasis.': [9], 'This': [10], 'attributed': [12], 'to': [13, 61, 115], 'the': [14, 37, 50, 121, 201], 'quality': [15], 'of': [16, 39, 43, 71, 76, 141, 170, 182, 208], 'human': [17], 'ligament': [19], 'fibroblasts': [20], '(hPDLFs)': [21], 'that': [22, 134, 159, 192], 'could': [23, 138, 146, 152], 'transfer': [24], 'occlusal': [25, 40, 63], 'into': [27, 111], 'biological': [28], 'signals': [29], 'modulating': [30], 'osteoblst': [31], 'differentiation.': [32], 'However,': [33], 'few': [34], 'studies': [35], 'investigated': [36], 'mechanism': [38], 'force‐induced': [41], 'osteodifferentiation': [42, 140], 'hPDLFs.': [44, 72, 142, 209], 'In': [45], 'our': [46, 189], 'study,': [47], 'we': [48, 118, 157], 'used': [49], 'cyclic': [51], 'mechanical': [52], 'tension': [53], '(CMT)': [54], 'at': [55], '10%': [56], 'elongation': [57], 'with': [58, 179], '0.5': [59], 'Hz': [60], 'mimic': [62], 'force,': [64], 'and': [65, 85, 104, 128, 164, 185], 'explored': [66], 'its': [67], 'effects': [68], 'on': [69, 120], 'osteogenesis': [70], 'Firstly,': [73], 'elevated': [74, 194], 'expressions': [75, 181], 'several': [77], 'osteoblast': [78, 206], 'marker': [79], 'genes': [80], '(Runx2,': [81], 'ATF4,': [82], 'SP7,': [83, 183], 'OCN,': [84, 184], 'BSP),': [86], 'as': [87, 89], 'well': [88], 'activated': [90], 'ERK1/2': [91, 127, 150, 198], 'pathway': [92, 124], 'were': [93], 'detected': [94], 'during': [95], 'CMT': [96, 113, 144, 160, 196], 'loading': [97, 145], '1,': [99], '3,': [100], '6,': [101], '12,': [102], '18,': [103], '24': [105], 'h.': [106], 'To': [107], 'gain': [108], 'further': [109], 'insight': [110], 'how': [112], 'contributed': [114], 'those': [116], 'effects,': [117], 'focused': [119], 'classic': [122], 'ERK1/2‐Runx2': [123], 'by': [125, 195], 'inhibiting': [126], 'overexpressing': [129], 'Runx2.': [130], 'Our': [131], 'results': [132], 'reflected': [133], 'Runx2': [135, 162], 'overexpression': [136], 'alone': [137], 'induce': [139], 'Meanwhile,': [143], 'intensify': [147], 'while': [148], 'combined': [149], 'blockage': [151], 'weaken': [153], 'this': [154], 'process.': [155], 'Furthermore,': [156], 'found': [158], 'promoted': [161], 'transcription': [163], 'phosphorylation': [165], 'via': [166, 197], 'ERK1/2;': [167], 'protein': [168], 'level': [169], 'phospho‐Runx2': [171], '(p‐Runx2),': [172], 'rather': [173], 'than': [174], 'Runx2,': [175], 'was': [176], 'in': [177, 204], 'parallel': [178], 'mRNA': [180], 'BSP.': [186], 'Taken': [187], 'together,': [188], 'study': [190], 'proved': [191], 'p‐Runx2,': [193], 'pathway,': [199], 'predominate': [202], 'factor': [203], 'promoting': [205], 'differentiation': [207], 'J.': [210], 'Cell.': [211], 'Physiol.': [212], '230:': [213], '2426–2436,': [214], '2015.': [215], '©': [216], '2015': [217], 'Wiley': [218], 'Periodicals,': [219], 'Inc.': [220]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1966491096', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 5}], 'updated_date': '2025-01-06T08:31:54.819234', 'created_date': '2016-06-24'}