Abstract: The FASEB JournalVolume 14, Issue 13 p. 1876-1888 ReviewFree to Read Co-repressors 2000 Les J. Burke, Les J. Burke Genetic Institute, Justus Liebig University, Heinrich Buff Ring 58–62,, D-35392 Giessen, GermanySearch for more papers by this authorAria Baniahmad, Corresponding Author Aria Baniahmad [email protected] Genetic Institute, Justus Liebig University, Heinrich Buff Ring 58–62,, D-35392 Giessen, GermanyCorrespondence: Genetic Institute, Justus Liebig University, Heinrich Buff Ring 58–62, D-35392 Giessen, Germany E-mail: [email protected]Search for more papers by this author Les J. Burke, Les J. Burke Genetic Institute, Justus Liebig University, Heinrich Buff Ring 58–62,, D-35392 Giessen, GermanySearch for more papers by this authorAria Baniahmad, Corresponding Author Aria Baniahmad [email protected] Genetic Institute, Justus Liebig University, Heinrich Buff Ring 58–62,, D-35392 Giessen, GermanyCorrespondence: Genetic Institute, Justus Liebig University, Heinrich Buff Ring 58–62, D-35392 Giessen, Germany E-mail: [email protected]Search for more papers by this author First published: 01 October 2000 https://doi.org/10.1096/fj.99-0943revCitations: 158Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat ABSTRACT In the last 5 years, many co-repressors have been identified in eukaryotes that function in a wide range of species, from yeast to Drosophila and humans. Co-repressors are coregulators that are recruited by DNA-bound transcriptional silencers and play essential roles in many pathways including differentiation, proliferation, programmed cell death, and cell cycle. Accordingly, it has been shown that aberrant interactions of co-repressors with tran-scriptional silencers provide the molecular basis of a variety of human diseases. Co-repressors mediate transcriptional silencing by mechanisms that include direct inhibition of the basal transcription machinery and recruitment of chromatin-modifying enzymes. Chromatin modification includes histone deacetylation, which is thought to lead to a compact chromatin structure to which the accessibility of transcriptional activators is impaired. In a general mechanistic view, the overall picture suggests that transcriptional si-lencers and co-repressors act in analogy to transcriptional activators and coactivators, but with the oppo-site effect leading to gene silencing. We provide a comprehensive overview of the currently known higher eukaryotic co-repressors, their mechanism of action, and their involvement in biological and pathophysiological pathways. We also show the dif-ferent pathways that lead to the regulation of co-repressor–silencer complex formation.—Burke, L. J., Baniahmad, A. Co-repressors 2000. FASEB J. 14, 1876–1888 (2000) REFERENCES 1Ayer, D. E., Lawrence, Q. A., and Eisenman, R. N. (1995) Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3. Cell 80, 767–776 2Schreiber-Agus, N., Chin, L., Chen, K., Torres, R., Rao, G., Guida, P., Skoultchi, A. I., and DePinho, R. A. 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Publication Year: 2000
Publication Date: 2000-10-01
Language: en
Type: review
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 201
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