Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1965957925', 'doi': 'https://doi.org/10.1016/j.jad.2012.08.044', 'title': 'Strong effects of environmental factors on prevalence and course of major depressive disorder are not moderated by 5-HTTLPR polymorphisms in a large Dutch sample', 'display_name': 'Strong effects of environmental factors on prevalence and course of major depressive disorder are not moderated by 5-HTTLPR polymorphisms in a large Dutch sample', 'publication_year': 2012, 'publication_date': '2012-09-27', 'ids': {'openalex': 'https://openalex.org/W1965957925', 'doi': 'https://doi.org/10.1016/j.jad.2012.08.044', 'mag': '1965957925', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23021380'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.jad.2012.08.044', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S113871862', 'display_name': 'Journal of Affective Disorders', 'issn_l': '0165-0327', 'issn': ['0165-0327', '1573-2517'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/j.jad.2012.08.044', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5104472607', 'display_name': 'Wouter J. Peyrot', 'orcid': 'https://orcid.org/0000-0001-7954-8383'}, 'institutions': [{'id': 'https://openalex.org/I4210124285', 'display_name': 'EMGO Institute for Health and Care Research', 'ror': 'https://ror.org/0258apj61', 'country_code': 'NL', 'type': 'facility', 'lineage': ['https://openalex.org/I4210124285', 'https://openalex.org/I4210151833', 'https://openalex.org/I865915315', 'https://openalex.org/I911458345']}, {'id': 'https://openalex.org/I4210108594', 'display_name': 'Amsterdam Neuroscience', 'ror': 'https://ror.org/01x2d9f70', 'country_code': 'NL', 'type': 'facility', 'lineage': ['https://openalex.org/I2802928900', 'https://openalex.org/I4210108594', 'https://openalex.org/I4210151833', 'https://openalex.org/I865915315', 'https://openalex.org/I887064364', 'https://openalex.org/I911458345']}], 'countries': ['NL'], 'is_corresponding': True, 'raw_author_name': 'Wouter J. Peyrot', 'raw_affiliation_strings': ['Department of Psychiatry, Neuroscience Campus Amsterdam and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Psychiatry, Neuroscience Campus Amsterdam and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I4210124285', 'https://openalex.org/I4210108594']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087978527', 'display_name': 'Christel M. Middeldorp', 'orcid': 'https://orcid.org/0000-0002-6218-0428'}, 'institutions': [{'id': 'https://openalex.org/I911458345', 'display_name': 'Amsterdam UMC Location VUmc', 'ror': 'https://ror.org/00q6h8f30', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210151833', 'https://openalex.org/I911458345']}, {'id': 'https://openalex.org/I2802928900', 'display_name': 'Academic Medical Center', 'ror': 'https://ror.org/03t4gr691', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802928900', 'https://openalex.org/I4210151833']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Christel M. Middeldorp', 'raw_affiliation_strings': ['Department of Biological Psychology, VU University, Amsterdam, The Netherlands', 'Department of Child and Adolescent Psychiatry, Academic Medical Center, Amsterdam, The Netherlands', 'Department of Child and Adolescent Psychiatry, VU University Medical Center, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Child and Adolescent Psychiatry, VU University Medical Center, The Netherlands', 'institution_ids': ['https://openalex.org/I911458345']}, {'raw_affiliation_string': 'Department of Biological Psychology, VU University, Amsterdam, The Netherlands', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Child and Adolescent Psychiatry, Academic Medical Center, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I2802928900']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008602701', 'display_name': 'Rick Jansen', 'orcid': 'https://orcid.org/0000-0002-3333-6737'}, 'institutions': [{'id': 'https://openalex.org/I4210124285', 'display_name': 'EMGO Institute for Health and Care Research', 'ror': 'https://ror.org/0258apj61', 'country_code': 'NL', 'type': 'facility', 'lineage': ['https://openalex.org/I4210124285', 'https://openalex.org/I4210151833', 'https://openalex.org/I865915315', 'https://openalex.org/I911458345']}, {'id': 'https://openalex.org/I4210108594', 'display_name': 'Amsterdam Neuroscience', 'ror': 'https://ror.org/01x2d9f70', 'country_code': 'NL', 'type': 'facility', 'lineage': ['https://openalex.org/I2802928900', 'https://openalex.org/I4210108594', 'https://openalex.org/I4210151833', 'https://openalex.org/I865915315', 'https://openalex.org/I887064364', 'https://openalex.org/I911458345']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Rick Jansen', 'raw_affiliation_strings': ['Department of Psychiatry, Neuroscience Campus Amsterdam and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Psychiatry, Neuroscience Campus Amsterdam and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I4210124285', 'https://openalex.org/I4210108594']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003786607', 'display_name': 'Johannes H. Smit', 'orcid': 'https://orcid.org/0000-0002-2062-8378'}, 'institutions': [{'id': 'https://openalex.org/I4210124285', 'display_name': 'EMGO Institute for Health and Care Research', 'ror': 'https://ror.org/0258apj61', 'country_code': 'NL', 'type': 'facility', 'lineage': ['https://openalex.org/I4210124285', 'https://openalex.org/I4210151833', 'https://openalex.org/I865915315', 'https://openalex.org/I911458345']}, {'id': 'https://openalex.org/I4210108594', 'display_name': 'Amsterdam Neuroscience', 'ror': 'https://ror.org/01x2d9f70', 'country_code': 'NL', 'type': 'facility', 'lineage': ['https://openalex.org/I2802928900', 'https://openalex.org/I4210108594', 'https://openalex.org/I4210151833', 'https://openalex.org/I865915315', 'https://openalex.org/I887064364', 'https://openalex.org/I911458345']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Johannes H. Smit', 'raw_affiliation_strings': ['Department of Psychiatry, Neuroscience Campus Amsterdam and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Psychiatry, Neuroscience Campus Amsterdam and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I4210124285', 'https://openalex.org/I4210108594']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076062731', 'display_name': 'Eco J. C. de Geus', 'orcid': 'https://orcid.org/0000-0001-6022-2666'}, 'institutions': [], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Eco.J.C. de Geus', 'raw_affiliation_strings': ['Department of Biological Psychology, VU University, Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Psychology, VU University, Amsterdam, The Netherlands', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029024758', 'display_name': 'Jouke‐Jan Hottenga', 'orcid': 'https://orcid.org/0000-0002-5668-2368'}, 'institutions': [], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Jouke-Jan Hottenga', 'raw_affiliation_strings': ['Department of Biological Psychology, VU University, Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Psychology, VU University, Amsterdam, The Netherlands', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038334172', 'display_name': 'Gonneke Willemsen', 'orcid': 'https://orcid.org/0000-0003-3755-0236'}, 'institutions': [], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Gonneke Willemsen', 'raw_affiliation_strings': ['Department of Biological Psychology, VU University, Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Psychology, VU University, Amsterdam, The Netherlands', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012976107', 'display_name': 'Jacqueline M. Vink', 'orcid': 'https://orcid.org/0000-0003-3910-3528'}, 'institutions': [], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Jacqueline M. Vink', 'raw_affiliation_strings': ['Department of Biological Psychology, VU University, Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Biological Psychology, VU University, Amsterdam, The Netherlands', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041474151', 'display_name': 'Susanne Virding', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Susanne Virding', 'raw_affiliation_strings': ['Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036068369', 'display_name': 'Isabel Barragán', 'orcid': 'https://orcid.org/0000-0002-8586-6502'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Isabel Barragan', 'raw_affiliation_strings': ['Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012663065', 'display_name': 'Magnus Ingelman‐Sundberg', 'orcid': 'https://orcid.org/0000-0002-7255-9079'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Magnus Ingelman-Sundberg', 'raw_affiliation_strings': ['Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076757975', 'display_name': 'Sarah C. Sim', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Sarah C. Sim', 'raw_affiliation_strings': ['Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079752137', 'display_name': 'Dorret I. Boomsma', 'orcid': 'https://orcid.org/0000-0002-7099-7972'}, 'institutions': [{'id': 'https://openalex.org/I4210124285', 'display_name': 'EMGO Institute for Health and Care Research', 'ror': 'https://ror.org/0258apj61', 'country_code': 'NL', 'type': 'facility', 'lineage': ['https://openalex.org/I4210124285', 'https://openalex.org/I4210151833', 'https://openalex.org/I865915315', 'https://openalex.org/I911458345']}, {'id': 'https://openalex.org/I4210108594', 'display_name': 'Amsterdam Neuroscience', 'ror': 'https://ror.org/01x2d9f70', 'country_code': 'NL', 'type': 'facility', 'lineage': ['https://openalex.org/I2802928900', 'https://openalex.org/I4210108594', 'https://openalex.org/I4210151833', 'https://openalex.org/I865915315', 'https://openalex.org/I887064364', 'https://openalex.org/I911458345']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Dorret I. Boomsma', 'raw_affiliation_strings': ['Department of Biological Psychology, VU University, Amsterdam, The Netherlands', 'Department of Psychiatry, Neuroscience Campus Amsterdam and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Psychiatry, Neuroscience Campus Amsterdam and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I4210124285', 'https://openalex.org/I4210108594']}, {'raw_affiliation_string': 'Department of Biological Psychology, VU University, Amsterdam, The Netherlands', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5055183685', 'display_name': 'Brenda W.J.H. Penninx', 'orcid': 'https://orcid.org/0000-0001-7779-9672'}, 'institutions': [{'id': 'https://openalex.org/I4210124285', 'display_name': 'EMGO Institute for Health and Care Research', 'ror': 'https://ror.org/0258apj61', 'country_code': 'NL', 'type': 'facility', 'lineage': ['https://openalex.org/I4210124285', 'https://openalex.org/I4210151833', 'https://openalex.org/I865915315', 'https://openalex.org/I911458345']}, {'id': 'https://openalex.org/I4210108594', 'display_name': 'Amsterdam Neuroscience', 'ror': 'https://ror.org/01x2d9f70', 'country_code': 'NL', 'type': 'facility', 'lineage': ['https://openalex.org/I2802928900', 'https://openalex.org/I4210108594', 'https://openalex.org/I4210151833', 'https://openalex.org/I865915315', 'https://openalex.org/I887064364', 'https://openalex.org/I911458345']}, {'id': 'https://openalex.org/I1334415907', 'display_name': 'University Medical Center Groningen', 'ror': 'https://ror.org/03cv38k47', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334415907']}, {'id': 'https://openalex.org/I2800006345', 'display_name': 'Leiden University Medical Center', 'ror': 'https://ror.org/05xvt9f17', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800006345']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Brenda W.J.H. Penninx', 'raw_affiliation_strings': ['Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands', 'Department of Psychiatry, Neuroscience Campus Amsterdam and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands', 'Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'Department of Psychiatry, Neuroscience Campus Amsterdam and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I4210124285', 'https://openalex.org/I4210108594']}, {'raw_affiliation_string': 'Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands', 'institution_ids': ['https://openalex.org/I1334415907']}, {'raw_affiliation_string': 'Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands', 'institution_ids': ['https://openalex.org/I2800006345']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 7, 'corresponding_author_ids': ['https://openalex.org/A5104472607'], 'corresponding_institution_ids': ['https://openalex.org/I4210124285', 'https://openalex.org/I4210108594'], 'apc_list': {'value': 3210, 'currency': 'USD', 'value_usd': 3210, 'provenance': 'doaj'}, 'apc_paid': {'value': 3210, 'currency': 'USD', 'value_usd': 3210, 'provenance': 'doaj'}, 'fwci': 0.93, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 31, 'citation_normalized_percentile': {'value': 0.797175, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '146', 'issue': '1', 'first_page': '91', 'last_page': '99'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11337', 'display_name': 'Tryptophan and brain disorders', 'score': 0.9918, 'subfield': {'id': 'https://openalex.org/subfields/2803', 'display_name': 'Biological Psychiatry'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11337', 'display_name': 'Tryptophan and brain disorders', 'score': 0.9918, 'subfield': {'id': 'https://openalex.org/subfields/2803', 'display_name': 'Biological Psychiatry'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10182', 'display_name': 'Child and Adolescent Psychosocial and Emotional Development', 'score': 0.9912, 'subfield': {'id': 'https://openalex.org/subfields/3203', 'display_name': 'Clinical Psychology'}, 'field': {'id': 'https://openalex.org/fields/32', 'display_name': 'Psychology'}, 'domain': {'id': 'https://openalex.org/domains/2', 'display_name': 'Social Sciences'}}, {'id': 'https://openalex.org/T10056', 'display_name': 'Neurotransmitter Receptor Influence on Behavior', 'score': 0.9813, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/5-httlpr', 'display_name': '5-HTTLPR', 'score': 0.66285294}, {'id': 'https://openalex.org/keywords/cidi', 'display_name': 'CIDI', 'score': 0.5713231}, {'id': 'https://openalex.org/keywords/depression', 'display_name': 'Depression', 'score': 0.42439544}], 'concepts': [{'id': 'https://openalex.org/C2780051608', 'wikidata': 'https://www.wikidata.org/wiki/Q42844', 'display_name': 'Major depressive disorder', 'level': 3, 'score': 0.92595375}, {'id': 'https://openalex.org/C5284366', 'wikidata': 'https://www.wikidata.org/wiki/Q3299516', 'display_name': '5-HTTLPR', 'level': 5, 'score': 0.66285294}, {'id': 'https://openalex.org/C2778963718', 'wikidata': 'https://www.wikidata.org/wiki/Q12757', 'display_name': 'CIDI', 'level': 4, 'score': 0.5713231}, {'id': 'https://openalex.org/C70410870', 'wikidata': 'https://www.wikidata.org/wiki/Q199906', 'display_name': 'Clinical psychology', 'level': 1, 'score': 0.4865357}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.47891653}, {'id': 'https://openalex.org/C118552586', 'wikidata': 'https://www.wikidata.org/wiki/Q7867', 'display_name': 'Psychiatry', 'level': 1, 'score': 0.47240752}, {'id': 'https://openalex.org/C151956035', 'wikidata': 'https://www.wikidata.org/wiki/Q1132755', 'display_name': 'Logistic regression', 'level': 2, 'score': 0.432811}, {'id': 'https://openalex.org/C2776867660', 'wikidata': 'https://www.wikidata.org/wiki/Q1814941', 'display_name': 'Depression (economics)', 'level': 2, 'score': 0.42439544}, {'id': 'https://openalex.org/C15744967', 'wikidata': 'https://www.wikidata.org/wiki/Q9418', 'display_name': 'Psychology', 'level': 0, 'score': 0.4234513}, {'id': 'https://openalex.org/C2778897192', 'wikidata': 'https://www.wikidata.org/wiki/Q410142', 'display_name': 'Serotonin transporter', 'level': 4, 'score': 0.3632321}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.27448735}, {'id': 'https://openalex.org/C2776317618', 'wikidata': 'https://www.wikidata.org/wiki/Q544006', 'display_name': 'Anxiety disorder', 'level': 3, 'score': 0.2430991}, {'id': 'https://openalex.org/C558461103', 'wikidata': 'https://www.wikidata.org/wiki/Q154430', 'display_name': 'Anxiety', 'level': 2, 'score': 0.16269326}, {'id': 'https://openalex.org/C2780733359', 'wikidata': 'https://www.wikidata.org/wiki/Q331769', 'display_name': 'Mood', 'level': 2, 'score': 0.10849759}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C2775864247', 'wikidata': 'https://www.wikidata.org/wiki/Q167934', 'display_name': 'Serotonin', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C162324750', 'wikidata': 'https://www.wikidata.org/wiki/Q8134', 'display_name': 'Economics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C139719470', 'wikidata': 'https://www.wikidata.org/wiki/Q39680', 'display_name': 'Macroeconomics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003865', 'descriptor_name': 'Depressive Disorder, Major', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D003865', 'descriptor_name': 'Depressive Disorder, Major', 'qualifier_ui': 'Q000453', 'qualifier_name': 'epidemiology', 'is_major_topic': True}, {'descriptor_ui': 'D059647', 'descriptor_name': 'Gene-Environment Interaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008016', 'descriptor_name': 'Life Change Events', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D050486', 'descriptor_name': 'Serotonin Plasma Membrane Transport Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054523', 'descriptor_name': 'Adult Survivors of Child Abuse', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D054523', 'descriptor_name': 'Adult Survivors of Child Abuse', 'qualifier_ui': 'Q000523', 'qualifier_name': 'psychology', 'is_major_topic': False}, {'descriptor_ui': 'D016022', 'descriptor_name': 'Case-Control Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003865', 'descriptor_name': 'Depressive Disorder, Major', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004522', 'descriptor_name': 'Educational Status', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006239', 'descriptor_name': 'Haplotypes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008137', 'descriptor_name': 'Longitudinal Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009426', 'descriptor_name': 'Netherlands', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009426', 'descriptor_name': 'Netherlands', 'qualifier_ui': 'Q000453', 'qualifier_name': 'epidemiology', 'is_major_topic': False}, {'descriptor_ui': 'D020641', 'descriptor_name': 'Polymorphism, Single Nucleotide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015995', 'descriptor_name': 'Prevalence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012307', 'descriptor_name': 'Risk Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050486', 'descriptor_name': 'Serotonin Plasma Membrane Transport Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012742', 'descriptor_name': 'Sex Offenses', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012742', 'descriptor_name': 'Sex Offenses', 'qualifier_ui': 'Q000523', 'qualifier_name': 'psychology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.jad.2012.08.044', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S113871862', 'display_name': 'Journal of Affective Disorders', 'issn_l': '0165-0327', 'issn': ['0165-0327', '1573-2517'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23021380', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.jad.2012.08.044', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S113871862', 'display_name': 'Journal of Affective Disorders', 'issn_l': '0165-0327', 'issn': ['0165-0327', '1573-2517'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/5', 'score': 0.68, 'display_name': 'Gender equality'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 44, 'referenced_works': ['https://openalex.org/W1539531350', 'https://openalex.org/W1603236906', 'https://openalex.org/W1966865235', 'https://openalex.org/W1970348977', 'https://openalex.org/W1975280345', 'https://openalex.org/W1977072843', 'https://openalex.org/W1982691391', 'https://openalex.org/W1984455353', 'https://openalex.org/W1988470975', 'https://openalex.org/W1999364579', 'https://openalex.org/W2000053835', 'https://openalex.org/W2001028204', 'https://openalex.org/W2020814125', 'https://openalex.org/W2040259741', 'https://openalex.org/W2042170262', 'https://openalex.org/W2044453219', 'https://openalex.org/W2046818084', 'https://openalex.org/W2050145168', 'https://openalex.org/W2050784922', 'https://openalex.org/W2052208159', 'https://openalex.org/W2087414280', 'https://openalex.org/W2095905365', 'https://openalex.org/W2096550964', 'https://openalex.org/W2097280669', 'https://openalex.org/W2106030064', 'https://openalex.org/W2113282160', 'https://openalex.org/W2114552460', 'https://openalex.org/W2114879270', 'https://openalex.org/W2116336801', 'https://openalex.org/W2122246853', 'https://openalex.org/W2124084192', 'https://openalex.org/W2126253977', 'https://openalex.org/W2135972055', 'https://openalex.org/W2138345444', 'https://openalex.org/W2151135161', 'https://openalex.org/W2155568298', 'https://openalex.org/W2156993271', 'https://openalex.org/W2162196924', 'https://openalex.org/W2171097731', 'https://openalex.org/W2582743722', 'https://openalex.org/W2599911490', 'https://openalex.org/W3152053505', 'https://openalex.org/W4247092709', 'https://openalex.org/W575347202'], 'related_works': ['https://openalex.org/W4256098562', 'https://openalex.org/W4242179075', 'https://openalex.org/W2333255482', 'https://openalex.org/W2155707407', 'https://openalex.org/W2115531649', 'https://openalex.org/W2065220020', 'https://openalex.org/W1995234726', 'https://openalex.org/W1980207569', 'https://openalex.org/W1713392082', 'https://openalex.org/W169828472'], 'abstract_inverted_index': {'There': [0], 'is': [1, 200], 'ongoing': [2], 'interest': [3], 'in': [4, 17, 49, 151], 'the': [5, 9, 34, 70, 108, 120, 127, 195, 212, 222], 'possible': [6], 'interaction': [7, 150, 188, 233], 'of': [8, 38, 56, 63, 110, 113, 130, 169, 179, 185, 194, 214, 226], 'serotonin-transporter-linked': [10], 'polymorphic': [11], 'region': [12], '(5-HTTLPR)': [13], 'with': [14, 59], 'environmental': [15, 42, 133, 155], 'factors': [16, 43, 134, 156, 207, 216], 'determining': [18], 'Major': [19], 'Depressive': [20], 'Disorder': [21], '(MDD).': [22], 'The': [23, 171], 'current': [24], 'study': [25], 'contributes': [26], 'to': [27], 'this': [28], 'research': [29], 'area': [30], 'by': [31, 205], 'comprehensively': [32], 'examining': [33], 'interaction-effects': [35], 'and': [36, 40, 47, 65, 92, 95, 115, 136, 145, 148, 159, 224], 'direct-effects': [37], '5-HTTLPR': [39, 114], 'five': [41, 132], 'on': [44, 162, 177, 183, 221], 'MDD': [45, 64, 73, 82, 89, 97, 122, 165], 'prevalence': [46], 'course': [48, 98, 168, 178, 225], 'a': [50, 60, 174, 218], 'well-characterized': [51], 'longitudinal': [52], 'sample.The': [53], 'sample': [54], 'consisted': [55], '1625': [57], 'patients': [58], 'CIDI-confirmed': [61], 'diagnosis': [62], '1698': [66], 'screened': [67], 'controls': [68], 'from': [69], 'Netherlands.': [71], 'Four': [72], 'outcomes': [74], 'were': [75, 117, 208], 'studied': [76], 'as': [77], 'dependent': [78], 'variables:': [79], 'one': [80, 96, 193], 'main': [81], 'prevalence-outcome': [83], '(all': [84], 'MDD),': [85, 94], 'two': [86], 'more': [87, 202], 'severe': [88], 'prevalence-outcomes': [90], '(suicidal': [91], 'chronic': [93], 'outcome': [99, 123], '(chronic': [100], 'versus': [101], 'non-chronic': [102], 'MDD).': [103], 'Because': [104], 'SNP': [105], 'rs25531': [106, 116], 'modifies': [107], 'effect': [109, 176], '5-HTTLPR,': [111], 'haplotypes': [112], 'measured.': [118], 'For': [119], 'four': [121, 164], 'measures,': [124], 'we': [125], 'examined': [126], 'direct': [128], 'effects': [129, 161], '5-HTTLPR/rs25531-haplotypes,': [131], '(lifetime': [135], 'recent': [137], 'stressful': [138], 'life-events,': [139], 'sexual': [140], 'abuse,': [141], 'low': [142], 'educational': [143], 'attainment,': [144], 'childhood': [146], 'trauma)': [147], 'their': [149], 'logistic': [152], 'regression': [153], 'models.The': [154], 'had': [157, 173, 217], 'large': [158], 'consistent': [160], 'all': [163], 'outcomes,': [166], 'including': [167], 'MDD.': [170, 186], '5-HTTLPR/rs25531-haplotype': [172], 'suggestive': [175], 'MDD,': [180, 227], 'but': [181, 228], 'not': [182, 201, 209], 'presence': [184, 223], 'Gene-by-environment': [187], 'was': [189, 234], 'significant': [190], '(<0.05)': [191], 'for': [192, 231], '20': [196], 'tests': [197], 'performed,': [198], 'which': [199], 'than': [203], 'expected': [204], 'chance.Environmental': [206], 'assessed': [210], 'before': [211], 'onset': [213], 'MDD.Environmental': [215], 'strong': [219], 'impact': [220], 'no': [229], 'evidence': [230], 'gene-by-environment': [232], 'found.': [235]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1965957925', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 2}], 'updated_date': '2025-01-05T04:53:48.913264', 'created_date': '2016-06-24'}