Title: Interaction of Thrombin with Thrombomodulin
Abstract: Annals of the New York Academy of SciencesVolume 485, Issue 1 p. 215-220 Interaction of Thrombin with Thrombomodulin C. T. ESMON, C. T. ESMON Thrombosis/Hematology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104Search for more papers by this authorN. L. ESMON, N. L. ESMON Thrombosis/Hematology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104Search for more papers by this authorS. KUROSAWA, S. KUROSAWA Thrombosis/Hematology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104Search for more papers by this authorA. E. JOHNSON, A. E. JOHNSON Department of Chemistry, University of Oklahoma, Norman, Oklahoma 73069Search for more papers by this author C. T. ESMON, C. T. ESMON Thrombosis/Hematology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104Search for more papers by this authorN. L. ESMON, N. L. ESMON Thrombosis/Hematology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104Search for more papers by this authorS. KUROSAWA, S. KUROSAWA Thrombosis/Hematology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104Search for more papers by this authorA. E. JOHNSON, A. E. JOHNSON Department of Chemistry, University of Oklahoma, Norman, Oklahoma 73069Search for more papers by this author First published: December 1986 https://doi.org/10.1111/j.1749-6632.1986.tb34583.xCitations: 18AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Jackson, C. M. & Y. Nemerson. 1980. Blood coagulation. Annu. Rev. Biochem. 49: 765– 811. 2 Seegers, W. H. 1981. Protein C and autoprothrombin II-A. Semin. Thromb. Hemostasis 7: 257– 261. 3 Esmon, C. T. 1984. Protein C. In Progress in Hemostasis and Thrombosis. T. H. Spaet, Ed. Vol. 7: 25– 54. Grune & Stratton, Inc. Orlando , FL . 4 Kisiel, W. 1979. Human plasma protein C: Isolation, characterization and mechanism of activation by α-thrombin. J. Clin. Invest. 64: 761– 769. 5 Walker, F. J., P. W. Sexton & C. T. Esmon. 1979. The inhibition of blood coagulation by activated protein C through the selective inactivation of activated factor V. Biochim. Biophys. Acta 571: 333– 342. 6 Marlar, R. A., A. J. Kleiss & J. H. Griffin. 1982. Mechanism of action of human activated protein C, a thrombin-dependent anticoagulant enzyme. Blood 59: 1067– 1072. 7 Esmon, C. T. & W. G. Owen. 1981. Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C. Proc. Natl. Acad. Sci. USA 78: 2249– 2252. 8 Maruyama, I., C. E. Bell & P. W. Majerus. 1985. Thrombomodulin is found on endothelium of arteries, veins, capillaries and lymphatics and on syncytiotrophoblasts of human placenta. J. Cell Biol. 101: 363– 371. 9 De Bault, L. E., N. L. Esmon, J. R. Olson & C. T. Esmon. 1986. Distribution of the thrombomodulin antigen in the rabbit vasculature. Lab. Invest. 54: 172– 178. 10 Busch, C., P. Cancilla, L. E. De Bault, J. C. Goldsmith & W. G. Owen. 1982. Use of endothelium cultured on microcarriers as a model for the microcirculation. Lab. Invest. 47: 498– 504. 11 Esmon, C. T., N. L. Esmon & K. W. Harris. 1982. Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation. J. Biol. Chem. 257: 7944– 7947. 12 Esmon, N. L., R. C. Carroll & C. T. Esmon. 1983. Thrombomodulin blocks the ability of thrombin to activate platelets. J. Biol. Chem. 258: 12238– 12242. 13 Maruyama, I., H. H. Salem, H. Ishii & P. W. Majerus. 1985. Human thrombomodulin is not an efficient inhibitor of the procoagulant activity of thrombin. J. Clin. Invest. 75: 987– 991. 14 Jakubowski, H. V., M. D. Kline & W. G. Owen. 1986. The effect of bovine throm-bomodulin on the specificity of bovine thrombin. J. Biol. Chem. 261: 3876– 3882. 15 Esmon, N. L., L. E. De Bault & C. T. Esmon. 1983. Proteolytic formation and properties of Gla-domainless protein C. J. Biol. Chem. 258: 5548– 5553. 16 Johnson, A. E., N. L. Esmon, T. M. Laue & C. T. Esmon. 1983. Structural changes required for activation of protein C are induced by Ca2+ binding to a high affinity site that does not contain γ-carboxyglutamic acid. J. Biol. Chem. 258: 5554– 5560. 17 Owen, W. G. & C. T. Esmon. 1981. Functional properties of an endothelial cell cofactor for thrombin-catalyzed activation of protein C. J. Biol. Chem. 256: 5532– 5535. 18 Dahlback, B. 1983. Purification of human vitamin K-dependent protein S and its limited proteolysis by thrombin. Biochem. 209: 837– 846. 19 Comp, P. C., R. R. Nixon, M. R. Cooper & C. T. Esmon. 1984. Familial protein S deficiency is associated with recurrent thrombosis. J. Clin. Invest. 74: 2082– 2088. 20 Berliner, L. J. & Y. Y. L. Shen. 1977. Active site fluorescent labeled dansyl and anthraniloyl human thrombin. Thromb. Res. 12: 15– 25. Citing Literature Volume485, Issue1Bioregulatory Functions of ThrombinDecember 1986Pages 215-220 ReferencesRelatedInformation
Publication Year: 1986
Publication Date: 1986-12-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 24
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot