Herp Stabilizes Neuronal Ca2+ Homeostasis and Mitochondrial Function during Endoplasmic Reticulum Stress

Name: Work Video:
Duration: 3 min 30 s
Sic L. Chan; Weiming Fu; Peisu Zhang; Aiwu Cheng; Jaewon Lee; Koichi Kokame; Mark P. Mattson
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'https://openalex.org/W2390927849', 'https://openalex.org/W2375108256', 'https://openalex.org/W2370978348', 'https://openalex.org/W2329067096', 'https://openalex.org/W2145294892', 'https://openalex.org/W2063538786', 'https://openalex.org/W2009035188', 'https://openalex.org/W2001930607', 'https://openalex.org/W1983031293'], 'abstract_inverted_index': {'In': [0, 233, 1423, 1634, 2448, 3561], 'response': [1, 234, 1033, 1155, 4426], 'to': [2, 92, 136, 235, 325, 369, 592, 602, 711, 726, 824, 1021, 1149, 1201, 1343, 1373, 1625, 1851, 1939, 1948, 1950, 1998, 2028, 2170, 2246, 2461, 2537, 2952, 2988, 3029, 3248, 3254, 3297, 3462, 3493, 3522, 3546, 3722, 3796, 3911, 3976, 4006, 4030, 4052, 4064, 4079, 4091, 4119, 4127, 4165, 4177, 4287, 4331, 4413], 'endoplasmic': [3, 236, 467, 475, 520], 'reticulum': [4, 237, 468, 513, 558], '(ER)': [5, 238, 469], 'stress,': [6, 141, 239, 374, 1770, 3786], 'cells': [7, 135, 240, 368, 741, 1491, 1558, 1729, 1773, 2008, 2036, 2590, 2794, 3028, 3042, 3204, 3273, 3307, 3325, 3629, 3848, 3901, 4003, 4028, 4051, 4063, 4074, 4103, 4110, 4114, 4189, 4211, 4235, 4286, 4320, 4328, 4393, 4395], 'launch': [8, 241], 'homeostatic': [9, 242], 'and': [10, 49, 52, 76, 95, 98, 160, 171, 196, 220, 243, 282, 285, 309, 328, 331, 393, 404, 429, 453, 573, 580, 583, 600, 633, 682, 733, 809, 821, 945, 1023, 1025, 1143, 1192, 1203, 1240, 1256, 1345, 1438, 1448, 1485, 1490, 1522, 1540, 1568, 1589, 1641, 1654, 1658, 1676, 1701, 1705, 1707, 1758, 1805, 1809, 1858, 1871, 1906, 1945, 1967, 2009, 2044, 2071, 2097, 2103, 2134, 2154, 2168, 2249, 2271, 2275, 2306, 2327, 2433, 2452, 2457, 2476, 2527, 2535, 2627, 2651, 2655, 2665, 2704, 2722, 2814, 2830, 2859, 2864, 2915, 2937, 2983, 3078, 3108, 3131, 3222, 3246, 3270, 3326, 3359, 3375, 3380, 3397, 3417, 3450, 3453, 3500, 3504, 3534, 3565, 3577, 3601, 3604, 3682, 3704, 3749, 3754, 3841, 3858, 3864, 3872, 3879, 4008, 4061, 4159, 4194, 4208, 4223, 4231, 4250, 4275, 4298, 4340, 4351, 4370, 4394], 'protective': [11, 244], 'responses,': [12, 245], 'but': [13, 246, 775, 3495, 3714, 4172], 'can': [14, 247, 586, 746, 1028], 'also': [15, 248, 777, 838, 1371, 3529, 3654, 3768, 3919, 4038, 4116, 4152], 'activate': [16, 249], 'cell': [17, 96, 250, 329, 735, 783, 825, 1450, 1815, 2357, 2840, 3035, 3138, 4166, 4363], 'death': [18, 251, 713, 736, 784, 1441, 4055, 4080, 4167, 4178, 4364], 'cascades.': [19, 252], 'A': [20, 253, 815, 1227, 2418, 3513], '54': [21, 254, 1229], 'kDa': [22, 255, 1230], 'integral': [23, 256], 'ER': [24, 60, 65, 88, 123, 140, 153, 166, 182, 188, 194, 198, 217, 231, 257, 293, 298, 321, 356, 373, 386, 399, 415, 421, 427, 431, 450, 464, 500, 545, 589, 604, 648, 665, 727, 744, 819, 835, 1031, 1095, 1153, 1196, 1235, 1249, 1366, 1443, 1769, 1806, 3263, 3438, 3446, 3463, 3668, 3697, 3738, 3744, 3785, 3812, 3828, 3933, 4053, 4120, 4147, 4170, 4191, 4201, 4414, 4424], 'membrane': [25, 258, 2782], 'protein': [26, 34, 83, 259, 267, 316, 571, 614, 630, 635, 643, 755, 993, 1231, 1245, 1263, 2164, 2367, 2417, 2520, 3468, 3568, 3657, 3683, 3705, 3774, 3824, 3966, 3989, 3999], 'called': [27, 260, 785, 1232], 'Herp': [28, 41, 68, 74, 82, 108, 117, 128, 144, 186, 204, 209, 223, 261, 274, 301, 307, 315, 341, 350, 361, 377, 419, 437, 442, 456, 1233, 1251, 1290, 1341, 1432, 1578, 1583, 1667, 1761, 1869, 1887, 2095, 2278, 2504, 2519, 2648, 3441, 3467, 3476, 3520, 3543, 3552, 3567, 3588, 3610, 3652, 3664, 3680, 3702, 3773, 3781, 3788, 3807, 3823, 3855, 3862, 3878, 3881, 3898, 3907, 3927, 3988, 3998, 4045, 4198, 4279, 4305, 4407, 4420], 'was': [29, 262, 1237, 1623, 1698, 1715, 1730, 1822, 1834, 1844, 1937, 2016, 2048, 2062, 2083, 2478, 2505, 2521, 2727, 2784, 2842, 2880, 2995, 3140, 3266, 3311, 3378, 3392, 3400, 3430, 3477, 3611, 3782, 3928, 3974, 4056, 4143, 4244], 'identified': [30, 263, 1239], 'as': [31, 264, 754, 813, 1242, 1460, 1596, 1787, 1824, 1836, 1891, 1985, 2174, 2501, 2549, 2744, 3071, 3073, 3166, 3623, 3936, 4145], 'a': [32, 86, 105, 148, 206, 225, 265, 319, 338, 381, 439, 458, 561, 608, 673, 779, 1151, 1243, 1253, 1429, 1498, 1502, 1590, 1628, 1825, 1837, 1954, 2072, 2146, 2157, 2222, 2254, 2485, 2491, 2502, 2616, 2824, 2998, 3044, 3088, 3127, 3288, 3360, 3368, 3723, 3842, 4018, 4092, 4124, 4128], 'stress-responsive': [33, 266, 1244], 'in': [35, 44, 46, 57, 81, 116, 210, 268, 277, 279, 290, 314, 349, 443, 567, 618, 670, 672, 716, 840, 996, 1086, 1247, 1349, 1364, 1377, 1433, 1527, 1559, 1751, 1828, 1841, 1912, 1964, 1972, 2085, 2206, 2211, 2225, 2229, 2242, 2381, 2430, 2437, 2507, 2524, 2593, 2596, 2609, 2619, 2629, 2676, 2694, 2800, 2810, 2838, 2888, 3043, 3049, 3061, 3087, 3093, 3102, 3114, 3136, 3210, 3226, 3274, 3305, 3313, 3332, 3394, 3444, 3447, 3459, 3470, 3483, 3508, 3516, 3525, 3531, 3572, 3589, 3614, 3627, 3658, 3670, 3679, 3685, 3709, 3772, 3793, 3822, 3846, 3884, 3899, 3914, 3931, 4002, 4241, 4317], 'non-neuronal': [36, 269, 3628], 'cells.': [37, 270, 2034, 3592, 3660, 4273], 'We': [38, 271, 4151], 'report': [39, 272], 'that': [40, 53, 273, 286, 640, 704, 743, 834, 1089, 1340, 1682, 3523, 3551, 3695, 3729, 3740, 3760, 3926, 3977], 'is': [42, 55, 99, 184, 201, 275, 288, 332, 417, 434, 560, 720, 828, 837, 1291, 1354, 3624, 3653, 3665, 4427], 'present': [43, 276, 1425, 3478], 'neurons': [45, 58, 278, 291, 671, 715, 1020, 1148, 1200, 1378, 3690, 3794], 'the': [47, 112, 280, 345, 568, 593, 612, 619, 628, 642, 647, 702, 712, 734, 748, 990, 1145, 1248, 1258, 1358, 1361, 1424, 1557, 1575, 1665, 1670, 1684, 1690, 1710, 1734, 1738, 1752, 1790, 1812, 1867, 1879, 2007, 2021, 2081, 2086, 2090, 2464, 2481, 2496, 2510, 2530, 2620, 2630, 2711, 2730, 2739, 2787, 2801, 2845, 2849, 2873, 2938, 2954, 2977, 2981, 3132, 3146, 3161, 3211, 3259, 3272, 3376, 3398, 3413, 3418, 3421, 3427, 3433, 3445, 3448, 3471, 3484, 3526, 3532, 3562, 3573, 3584, 3615, 3625, 3674, 3710, 3737, 3762, 3766, 3817, 3827, 3859, 3894, 3915, 3922, 3932, 3969, 3979, 3995, 4027, 4048, 4101, 4146, 4232, 4248, 4336, 4368, 4423], 'developing': [48, 281], 'adult': [50, 283, 3509, 3563, 3590], 'brain,': [51, 284], 'it': [54, 287, 719, 1353], 'regulated': [56, 289], 'by': [59, 101, 130, 139, 147, 176, 203, 292, 334, 363, 372, 380, 409, 436, 606, 1494, 1627, 1717, 1763, 2221, 2435, 2509, 2523, 2539, 2615, 2738, 2848, 2882, 3039, 3145, 3157, 3268, 3367, 3432, 3606, 3667, 3870, 4058, 4082, 4169, 4180, 4281, 4321, 4353], 'stress;': [61, 294], 'sublethal': [62, 295], 'levels': [63, 75, 84, 296, 308, 317, 1802, 3469, 3482, 3496, 3569, 3684, 3700, 3789, 3825, 3876, 3983, 4000, 4046, 4347], 'of': [64, 111, 127, 143, 152, 157, 162, 169, 180, 193, 230, 297, 344, 360, 376, 385, 390, 395, 402, 413, 426, 463, 486, 531, 570, 595, 622, 627, 646, 675, 706, 714, 739, 750, 781, 806, 818, 989, 998, 1001, 1018, 1147, 1190, 1289, 1556, 1565, 1638, 1727, 1754, 1792, 1801, 1803, 1814, 1915, 1956, 2006, 2012, 2060, 2066, 2080, 2093, 2118, 2356, 2365, 2469, 2484, 2622, 2632, 2706, 2719, 2803, 2817, 2868, 2872, 3027, 3041, 3046, 3090, 3122, 3150, 3160, 3213, 3218, 3258, 3262, 3280, 3322, 3426, 3435, 3519, 3542, 3587, 3677, 3701, 3720, 3736, 3743, 3765, 3780, 3806, 3819, 3861, 3877, 3886, 3897, 3906, 3972, 3978, 3984, 3987, 4026, 4043, 4050, 4067, 4089, 4095, 4100, 4109, 4131, 4197, 4205, 4234, 4252, 4278, 4345, 4348, 4361, 4372, 4406, 4411, 4419], 'stress': [66, 89, 195, 299, 322, 428, 582, 605, 623, 666, 728, 745, 820, 836, 1032, 1154, 1807, 3669, 3829, 4171, 4425], 'increase': [67, 300, 3678, 3792, 3821], 'levels,': [69, 155, 302, 388], 'whereas': [70, 178, 303, 411], 'higher': [71, 304, 3892, 3993], 'doses': [72, 305], 'decrease': [73, 80, 306, 313, 3515], 'induce': [77, 310, 1029, 1768, 3696], 'apoptosis.': [78, 311, 4203, 4290], 'The': [79, 312, 466, 1187, 1287, 1649, 1679, 1713, 1817, 1935, 1959, 2106, 2140, 2261, 2471, 2546, 2640, 2834, 2957, 2973, 3302, 3389, 3409, 3424, 3539, 3778, 3875, 3961, 3982, 4041], 'following': [85, 318, 1442, 2091, 4004, 4123], 'lethal': [87, 320], 'occurs': [90, 323], 'prior': [91, 324, 1850], 'mitochondrial': [93, 158, 221, 326, 391, 454, 2955, 2982, 3390], 'dysfunction': [94, 327], 'death,': [97, 330], 'mediated': [100, 333], 'caspases': [102, 335, 808, 3074], 'which': [103, 336, 616, 802, 1369, 1697, 1843, 3799, 3917, 4022], 'generate': [104, 337, 1626], '30-kDa': [106, 339], 'proteolytic': [107, 340, 987], 'fragment.': [109, 342], 'Mutagenesis': [110, 343], 'caspase': [113, 163, 172, 346, 396, 405, 1818, 2339, 3069], 'cleavage': [114, 347, 2538], 'site': [115, 348, 2483], 'enhances': [118, 351], 'its': [119, 352, 822, 3865], 'neuroprotective': [120, 226, 353, 459], 'function': [121, 159, 227, 354, 392, 460, 1197, 1288], 'during': [122, 355, 3474, 3487, 3558, 3826, 4422], 'stress.': [124, 232, 357, 465, 1444, 3698], 'While': [125, 358], 'suppression': [126, 161, 359, 394, 4277], 'induction': [129, 179, 362, 412, 4280, 4418], 'RNA': [131, 364, 2042, 2047, 2061, 4282, 4293], 'interference': [132, 365, 4283], 'sensitizes': [133, 366, 4284], 'neural': [134, 367, 3659, 4188], 'apoptosis': [137, 370, 786, 1204, 3801, 4122], 'induced': [138, 371, 3666, 3769, 4081, 4168, 4179, 4289], 'overexpression': [142, 375, 3863, 4196], 'promotes': [145, 378], 'survival': [146, 379], 'mechanism': [149, 382], 'involving': [150, 383], 'stabilization': [151, 384], 'Ca2+': [154, 189, 199, 213, 218, 387, 422, 432, 446, 451, 574, 584, 708, 731, 1096, 1367, 1436, 3153, 3264], 'preservation': [156, 389], '3': [164, 397, 3070], 'activation.': [165, 398], 'stress-induced': [167, 400, 4054, 4121, 4192, 4202], 'activation': [168, 401, 805], 'JNK/c-Jun': [170, 403], '12': [173, 406, 2340, 4014], 'are': [174, 407, 1652, 1661, 4247, 4367], 'reduced': [175, 408], 'Herp,': [177, 410, 498, 543, 3833, 4158, 4349], 'major': [181, 414], 'chaperones': [183, 416, 636, 756], 'unaffected.': [185, 418], 'prevents': [187, 420], 'overload': [190, 423, 585], 'under': [191, 228, 424, 461], 'conditions': [192, 229, 425, 462, 678, 2109], 'agonist-induced': [197, 430], 'release': [200, 433, 2879], 'attenuated': [202, 435], 'suggesting': [205, 438, 3621], 'role': [207, 440, 1363, 1430, 3557], 'for': [208, 441, 1431, 1749, 1760, 1783, 1798, 1810, 1899, 1901, 1904, 1942, 2032, 2064, 2121, 2126, 2131, 2163, 2239, 2421, 2445, 2598, 2611, 2635, 2673, 2797, 2856, 2931, 2946, 2967, 3031, 3051, 3058, 3068, 3080, 3095, 3099, 3111, 3207, 3386, 3402, 3784, 4013, 4214, 4301, 4335, 4343, 4359, 4377, 4429], 'regulating': [211, 444, 1365], 'neuronal': [212, 445, 1440, 2052, 4431], 'signaling.': [214, 447], 'By': [215, 448], 'stabilizing': [216, 449, 1434], 'homeostasis': [219, 452, 709, 732, 1097, 1437], 'functions,': [222, 455], 'serves': [224, 457], '1The': [470, 515], 'abbreviations': [471, 516], 'used': [472, 517, 2063, 2084, 2460, 2855], 'are:': [473, 518], 'ER,': [474, 519, 3767], 'reticulum;': [476, 521], 'PBS,': [477, 522, 2703], 'phosphate-buffered': [478, 523], 'saline;': [479, 524, 2214], 'JNK,': [480, 525], 'Jun': [481, 526], 'N-terminal': [482, 527, 1586, 3838], 'kinase;': [483, 528], 'ANOVA,': [484, 529], 'analysis': [485, 530, 4355], 'variance;': [487, 532], 'grp,': [488, 533], 'glucose-regulated': [489, 534, 629], 'protein;': [490, 497, 501, 535, 542, 546], 'AD,': [491, 536], "Alzheimer's": [492, 537, 846, 981], 'disease;': [493, 538], 'APP,': [494, 539], 'amyloid': [495, 509, 540, 554, 991, 1002], 'precursor': [496, 541, 992], 'homocysteine-induced': [499, 544], 'z,': [502, 547], 'benzyloxycarbonyl;': [503, 548], 'fmk,': [504, 549], 'fluoromethylketone;': [505, 550], 'PS1,': [506, 551], 'presenilin-1;': [507, 552], 'Aβ,': [508, 553], 'β;': [510, 555], 'SERCA,': [511, 556], 'sarco/endoplasmic': [512, 557], 'Ca2+-ATPase.': [514, 559], 'unique': [562], 'cellular': [563, 707, 730, 1435, 2818], 'compartment': [564], 'simultaneously': [565], 'involved': [566], 'processes': [569], 'synthesis': [572, 2065, 2075], 'homeostasis.': [575], 'Various': [576], 'conditions,': [577, 718], 'including': [578, 625, 679, 845], 'oxidative': [579, 1026], 'metabolic': [581, 1024], 'interfere': [587], 'with': [588, 1501, 1584, 1703, 1776, 1873, 1917, 2039, 2151, 2370, 2416, 2474, 2490, 2605, 2702, 3619, 3693, 3836, 3921, 4070, 4107, 4218, 4265, 4270, 4386, 4391, 4397], 'functions': [590], 'leading': [591], 'accumulation': [594], 'misfolded': [596], 'proteins.': [597], 'Cells': [598, 1505, 2669, 2698, 3054, 3083, 3284, 3810], 'sense': [599, 1896], 'respond': [601], 'such': [603, 753, 812], 'activating': [607], 'signaling': [609], 'cascade': [610], 'termed': [611], 'unfolded': [613], 'response,': [615, 3830], 'results': [617, 984, 4136], 'transcriptional': [620], 'up-regulation': [621, 3779], 'proteins': [624, 3883], 'members': [626], '(grp)': [631], 'family': [632], 'other': [634, 1992, 4155], '(calnexin,': [637], 'calreticulin,': [638], 'ERp72)': [639], 'enhance': [641], 'folding': [644], 'capability': [645], '(1Patil': [649], 'C.': [650], 'Walter': [651], 'P.': [652, 881], 'Curr.': [653], 'Opin.': [654], 'Cell': [655, 792, 887, 1133, 1446, 1472, 1572, 2022, 2309, 2720, 3814, 4416], 'Biol.': [656, 793, 888, 1134, 1172, 1272, 1324, 1473, 1606, 2188, 2286, 3637, 3946], '2001;': [657, 692, 794, 1174], '13:': [658], '349-355Crossref': [659], 'PubMed': [660, 695, 770, 797, 892, 919, 942, 975, 1012, 1056, 1079, 1117, 1138, 1182, 1224, 1282, 1334, 1418, 1477, 1616, 2198, 2296, 2580, 2776, 3021, 3198, 3647, 3956], 'Scopus': [661, 696, 771, 798, 893, 920, 976, 1013, 1057, 1080, 1139, 1183, 1283, 1335, 1419, 1478, 1617, 2199, 2297, 2581, 2777, 3199, 3648, 3957], '(669)': [662], 'Google': [663, 698, 773, 800, 895, 922, 943, 978, 1015, 1059, 1082, 1118, 1141, 1185, 1225, 1285, 1337, 1421, 1480, 1619, 2201, 2299, 2583, 2779, 3022, 3201, 3650, 3959], 'Scholar).': [664, 699, 1016, 1083, 1186, 1226, 1286, 1422, 1481, 1620, 2202, 2584, 2780, 3023, 3202, 3960], 'has': [667], 'been': [668], 'documented': [669], 'variety': [674], 'acute': [676], 'pathological': [677], 'cerebral': [680, 3485, 3527, 3574], 'ischemia': [681], 'severe': [683], 'epileptic': [684], 'seizures': [685], '(2Paschen': [686], 'W.': [687, 762, 1396], 'Frandsen': [688], 'A.': [689, 878, 952], 'J.': [690, 858, 870, 937, 1070, 1074, 1112, 1132, 1171, 1219, 1271, 1323, 1394, 1605, 2187, 2285, 2343, 2575, 2771, 3016, 3193, 3636, 3945], 'Neurochem.': [691, 2576, 2772, 3194], '79:': [693], '719-725Crossref': [694], '(208)': [697], 'However,': [700], 'despite': [701], 'fact': [703], 'disruption': [705], 'contributes': [710], 'these': [717, 1560, 1999], 'not': [721, 1355, 3537, 3757, 3791, 3803, 3964, 4174, 4184], 'known': [722, 1356, 1993], 'how': [723], 'molecular': [724], 'responses': [725], 'modify': [729, 3761], 'process.': [737], 'Studies': [738], 'cultured': [740, 1019, 3686, 3711], 'suggest': [742, 833], 'stimulate': [747], 'expression': [749, 1762, 3518, 3541, 3986, 4421], 'cytoprotective': [751, 1152], 'genes': [752, 1994], '(3Yu': [757], 'Z.': [758], 'Luo': [759], 'H.': [760, 1064, 1270, 1303, 1305, 1388, 1604, 2284, 3635, 3944], 'Fu': [761], 'Mattson': [763, 1110, 1128, 1217, 2185, 3014], 'M.P.': [764, 898, 1006, 1035, 1129, 1404, 1464, 2186], 'Exp.': [765], 'Neurol.': [766], '1999;': [767, 889, 2577, 2773, 3195], '155:': [768], '302-314Crossref': [769], '(402)': [772], 'Scholar)': [774, 979, 1142, 1338], 'may': [776, 803, 1198, 3553], 'trigger': [778], 'form': [780, 3217], 'programmed': [782], '(4Ferri': [787], 'K.F.': [788], 'Kroemer': [789], 'G.': [790, 1164, 1398, 2544], 'Nat.': [791, 886], '3:': [795], '255-263Crossref': [796], '(1284)': [799], 'Scholar),': [801, 923, 944, 2300, 3651], 'involve': [804], 'ER-associated': [807], 'transcription': [810, 2526], 'factors': [811], 'Gadd153.': [814], 'better': [816], 'understanding': [817], 'links': [823], 'survival/death': [826], 'decisions': [827], 'therefore': [829], 'needed.': [830], 'Recent': [831], 'findings': [832], 'implicated': [839], 'several': [841, 4154], 'chronic': [842], 'neurodegenerative': [843], 'disorders': [844], '(5Katayama': [847], 'T.': [848, 856, 860, 862, 872, 954, 956, 968, 1062, 1309, 1313, 1315], 'Imaizumi': [849], 'K.': [850, 854, 962, 964, 1103, 1210, 1266, 1301, 1320, 1402, 1600, 2280, 3007, 3631, 3940], 'Sato': [851], 'N.': [852, 1066, 1107, 1214, 3011], 'Miyoshi': [853], 'Kudo': [855], 'Hitomi': [857], 'Morihara': [859], 'Yoneda': [861], 'Gomi': [863], 'F.': [864], 'Mori': [865], 'Y.': [866, 868, 874, 948, 1123, 1299], 'Nakano': [867], 'Takeda': [869, 882], 'Tsuda': [871], 'Itoyama': [873], 'Murayama': [875], 'O.': [876], 'Takashima': [877], 'St': [879], 'George-Hyslop': [880], 'M.': [883, 885, 1311, 2180], 'Tohyama': [884], '1:': [890], '479-485Crossref': [891], '(483)': [894], 'Scholar,': [896, 1060, 1119], '6Mattson': [897], 'LaFerla': [899, 1036, 1130], 'F.M.': [900, 1037, 1131], 'Chan': [901, 1038], 'S.L.': [902, 1039, 2178], 'Leissring': [903, 1040], 'M.A.': [904, 1041, 1121, 2564, 2760, 3182], 'Shepel': [905, 1042], 'P.N.': [906, 1043], 'Geiger': [907, 1044, 2183], 'J.D.': [908, 1045, 2184], 'Trends': [909, 1046], 'Neurosci.': [910, 938, 1047, 1113, 1220, 3017], '2000;': [911, 1048, 1076, 1135, 1274, 1410, 1608, 2190, 2288, 3639, 3948], '23:': [912, 1049], '222-229Abstract': [913, 1050], 'Full': [914, 916, 1051, 1053, 1177, 1179, 1277, 1279, 1329, 1331, 1413, 1415, 1611, 1613, 2193, 2195, 2291, 2293, 3642, 3644, 3951, 3953], 'Text': [915, 917, 1052, 1054, 1178, 1180, 1278, 1280, 1330, 1332, 1414, 1416, 1612, 1614, 2194, 2196, 2292, 2294, 3643, 3645, 3952, 3954], 'PDF': [918, 1055, 1181, 1281, 1333, 1417, 1615, 2197, 2295, 3646, 3955], '(417)': [921, 1058], "Parkinson's": [924], '(7Ryu': [925], 'E.J.': [926], 'Harding': [927], 'H.P.': [928], 'Angelastro': [929], 'J.M.': [930], 'Vitolo': [931], 'O.V.': [932], 'Ron': [933], 'D.': [934], 'Greene': [935], 'L.A': [936], '2002;': [939, 972, 1326], '22:': [940], '10690-10698Crossref': [941], "Huntington's": [946], '(8Kouroku': [947], 'Fujita': [949], 'E.': [950, 960, 1068, 1159, 1390, 1392], 'Jimbo': [951], 'Kikuchi': [953], 'Yamagata': [955], 'Momoi': [957, 967], 'M.Y.': [958], 'Kominami': [959], 'Kuida': [961], 'Sakamaki': [963], 'Yonehara': [965], 'S.': [966, 1161, 1384, 2560, 2756, 3178], 'Hum.': [969], 'Mol.': [970], 'Genet.': [971], '11:': [973], '1505-1515Crossref': [974], '(168)': [977], 'diseases.': [980], 'disease': [982], '(AD)': [983], 'from': [985, 1454, 1866, 2050, 2342, 2543, 3490, 3544], 'altered': [986, 1374], 'processing': [988, 1348, 1376], '(APP),': [994], 'resulting': [995, 2958, 3410], 'aggregation': [997], 'neurotoxic': [999], 'forms': [1000], 'β-peptide': [1003], '(Aβ)': [1004], '(9Mattson': [1005], 'Physiol.': [1007], 'Rev.': [1008], '1997;': [1009, 1114, 1221, 3018], '77:': [1010], '1081-1132Crossref': [1011], '(872)': [1014], 'Exposure': [1017], 'Aβ-peptide,': [1022], 'insults': [1027], 'an': [1030, 1585, 1874, 3250, 3298, 3437, 3555, 3655, 3770, 3820, 3837], '(6Mattson': [1034], '10Nakagawa': [1061], 'Zhu': [1063], 'Morishima': [1065], 'Li': [1067], 'Xu': [1069], 'Yankner': [1071], 'B.A.': [1072], 'Yuan': [1073], 'Nature.': [1075], '403:': [1077], '98-103Crossref': [1078], '(2912)': [1081], 'Moreover,': [1084], 'mutations': [1085, 1194], 'presenilin-1': [1087], '(PS1)': [1088], 'cause': [1090], 'early-onset': [1091], 'familial': [1092], 'AD': [1093], 'perturb': [1094], '(11Guo': [1098, 1205, 3002], 'Q.': [1099, 1206, 3003], 'Sopher': [1100, 1207, 3004], 'B.L.': [1101, 1208, 3005], 'Furukawa': [1102, 1209, 3006], 'Pham': [1104, 1211, 3008], 'D.G.': [1105, 1212, 3009], 'Robinson': [1106, 1213, 3010], 'Martin': [1108, 1215, 3012], 'G.M.': [1109, 1216, 3013], 'M.P': [1111, 1218, 3015], '17:': [1115, 1222, 3019], '4212-4222Crossref': [1116, 1223, 3020], '12Leissring': [1120], 'Akbari': [1122], 'Fanger': [1124], 'C.M.': [1125], 'Cahalan': [1126], 'M.D.': [1127], '149:': [1136], '793-798Crossref': [1137], '(284)': [1140], 'impair': [1144], 'ability': [1146], 'engage': [1150], '(20Rao': [1156], 'R.V.': [1157], 'Hermel': [1158], 'Castro-Obregon': [1160], 'del': [1162], 'Rio': [1163], 'Ellerby': [1165, 1167, 2557, 2753, 3175], 'L.M.': [1166, 2552, 2748, 3170], 'H.M.': [1168, 2558, 2754, 3176], 'Bredesen': [1169, 2573, 2769, 3191], 'D.E.': [1170, 2574, 2770, 3192], 'Chem.': [1173, 1273, 1325, 1607, 2189, 2287, 3638, 3947], '276:': [1175], '33869-33874Abstract': [1176], '(542)': [1184], 'adverse': [1188], 'effects': [1189], 'Aβ': [1191], 'PS1': [1193, 1344, 1362, 2317, 2666], 'on': [1195, 2145, 3287, 4047], 'sensitize': [1199], 'excitotoxicity': [1202], 'novel': [1228], '(homocysteine-induced': [1234], 'protein)': [1236], 'recently': [1238], 'characterized': [1241, 1759], 'localized': [1246, 3930], 'membrane;': [1250], 'contains': [1252], 'ubiquitin-like': [1254], 'domain': [1255], 'resembles': [1257], 'human': [1259, 1577, 1582], 'DNA': [1260, 1566, 1719, 1724, 2732], 'excision': [1261], 'repair': [1262], 'hHR23': [1264], '(13Kokame': [1265, 1599, 2279, 3630, 3939], 'Agarwala': [1267, 1601, 2281, 3632, 3941], 'K.L.': [1268, 1602, 2282, 3633, 3942], 'Kato': [1269, 1603, 2283, 3634, 3943], '275:': [1275, 1609, 2191, 2289, 3640, 3949], '32846-32853Abstract': [1276, 1610, 2290, 3641, 3950], '(256)': [1284, 1618, 2298, 3649, 3958], 'unknown.': [1292], 'Sai': [1293], 'et': [1294], 'al.': [1295], '(14Sai': [1296], 'X.': [1297], 'Kawamura': [1298], 'Kokame': [1300], 'Yamaguchi': [1302], 'Shiraishi': [1304], 'Suzuki': [1306, 1308], 'R.': [1307], 'Kawaichi': [1310], 'Miyata': [1312], 'Kitamura': [1314], 'De': [1316], 'Strooper': [1317], 'B.': [1318], 'Yanagisawa': [1319], 'Komano': [1321], 'K.H.': [1322], '277:': [1327], '12915-12920Abstract': [1328], '(119)': [1336], 'showed': [1339], 'binds': [1342], 'alters': [1346], 'APP': [1347, 1375], 'HEK-293': [1350], 'cells,': [1351, 4072], 'although': [1352], 'whether': [1357, 3663], 'interaction': [1359], 'affects': [1360], 'homeostasis,': [1368], 'might': [1370], 'contribute': [1372], '(15Yoo': [1379], 'A.S.': [1380, 2554, 2750, 3172], 'Cheng': [1381], 'I.': [1382], 'Chung': [1383], 'Grenfell': [1385], 'T.Z.': [1386], 'Lee': [1387], 'Pack-Chung': [1389], 'Handler': [1391], 'Shen': [1393], 'Xia': [1395], 'Tesco': [1397], 'Saunders': [1399], 'A.J.': [1400], 'Ding': [1401], 'Frosch': [1403], 'Tanzi': [1405], 'R.E.': [1406], 'Kim': [1407], 'T.W.': [1408], 'Neuron.': [1409], '27:': [1411], '561-572Abstract': [1412], '(271)': [1420], 'study': [1426], 'we': [1427, 3582, 3672, 3831], 'demonstrate': [1428], 'preventing': [1439], 'Neuronal': [1445], 'Cultures—Hippocampal': [1447], 'cortical': [1449, 3327, 3689, 3712], 'cultures': [1451, 1561, 1795, 2053, 2853, 3316], 'were': [1452, 1488, 1492, 1506, 1548, 1562, 1594, 1647, 1674, 1687, 1745, 1774, 1796, 1864, 1889, 1910, 1962, 1980, 2037, 2110, 2143, 2173, 2204, 2236, 2251, 2368, 2414, 2459, 2591, 2670, 2699, 2708, 2795, 2821, 2854, 2862, 2886, 2924, 2940, 2960, 2986, 3037, 3055, 3084, 3124, 3155, 3205, 3285, 3330, 3365, 3505, 3570, 3595, 3706, 3856, 3868, 3890, 3918, 3990, 4034, 4075, 4104, 4115, 4137, 4161, 4173, 4212, 4315, 4329], 'established': [1453], '18': [1455], 'day': [1456, 3502, 3548, 4324], 'Sprague-Dawley': [1457], 'rat': [1458, 1868, 2335, 3564, 3688], 'embryos': [1459], 'described': [1461, 1597, 1986, 2175, 2550, 2745, 3000, 3167], 'previously': [1462, 1598, 2176, 2746, 3001, 3168, 3937], '(16Mattson': [1463], 'Barger': [1465], 'S.W.': [1466], 'Begley': [1467], 'J.G.': [1468], 'Mark': [1469], 'R.J.': [1470], 'Methods': [1471], '1995;': [1474], '46:': [1475], '187-216Crossref': [1476], '(310)': [1479], 'Briefly,': [1482, 1893, 2793, 3024, 3203], 'intact': [1483], 'hippocampi': [1484], 'neocortical': [1486], 'fragments': [1487], 'trypsinized,': [1489], 'dissociated': [1493], 'mild': [1495], 'trituration': [1496], 'using': [1497, 1550, 1733, 1737, 1878, 1982, 2020, 2054, 2068, 2089, 2156, 2253, 2529, 2710, 2729, 2786, 2823, 2844, 2997, 3126, 3142], 'Pasteur': [1499], 'pipette': [1500], 'fire-polished': [1503], 'tip.': [1504], 'seeded': [1507], 'into': [1508, 1689, 1709, 1853, 2480, 3597], 'polyethyleneimine-coated': [1509], 'plastic': [1510, 1515], '35-': [1511], 'or': [1512, 1517, 1580, 1780, 2359, 2376, 2419, 2638, 2685, 2737, 3732, 3834, 4226, 4238, 4307, 4357], '60-mm': [1513], 'diameter': [1514], 'dishes': [1516, 4374], '22': [1518], 'mm2': [1519], 'glass': [1520], 'coverslips,': [1521], 'maintained': [1523], 'at': [1524, 1847, 1953, 1969, 2113, 2137, 2217, 2232, 2424, 2442, 2601, 2927, 2934, 2942, 2949, 2963, 2970, 3371, 3382, 3405, 3479, 4021], '37': [1525], '°C': [1526, 1941, 1952, 1971, 2120, 2125, 2130, 2219, 2444, 2951], 'Neurobasal': [1528], 'medium': [1529], 'containing': [1530, 1574, 2362, 2440, 2678, 2891, 3063, 3104, 3116], 'B-27': [1531], 'supplements': [1532], '(Invitrogen),': [1533, 2489], '2': [1534, 1931, 2058, 2111, 2392, 2404, 2636, 3214, 3549], 'mm': [1535, 1542, 1839, 1927, 1932, 2385, 2390, 2393, 2409, 2893, 2896, 2901, 2904, 2907, 2910, 2913, 3339, 3342, 3345, 3348, 3351, 3354, 3357], 'l-glutamine,': [1536], '0.001%': [1537], 'gentamycin': [1538], 'sulfate': [1539], '1': [1541, 1838, 1957, 2240, 2422, 2674, 2906, 2909, 2912, 2968, 3281, 3350, 3353, 3356, 3403], 'HEPES': [1543], '(pH': [1544], '7.2).': [1545], 'All': [1546], 'experiments': [1547], 'performed': [1549, 1624, 3267], '7–8-day-old': [1551], 'cultures;': [1552], 'greater': [1553, 4023], 'than': [1554, 3893, 3994, 4024], '90%': [1555], 'neurons.': [1563], 'Generation': [1564], 'Constructs': [1567], 'Stably': [1569, 1742], 'Transfected': [1570], 'PC12': [1571, 1728, 1772, 2033, 3324, 3809, 3847, 3889, 4210, 4272, 4285, 4319, 4327], 'Lines—Plasmids': [1573], 'full-length': [1576, 1581, 2518], 'cDNA': [1579, 2067, 2082], 'c-Myc': [1587, 2660, 3839], 'tag': [1588, 1593, 3840], 'C-terminal': [1591, 3843], 'FLAG': [1592, 3844], 'constructed': [1595], 'Site-directed': [1621], 'mutagenesis': [1622], 'PCR-based': [1629], 'primer': [1630], 'overlap': [1631], 'extension': [1632], 'method.': [1633], 'brief,': [1635], 'same': [1636], 'pair': [1637, 1861], 'flanking': [1639, 1650], 'primers': [1640, 1646, 1651, 1673, 1897, 1909, 2070], 'two': [1642], 'different': [1643], 'mutant': [1644, 1666, 1672, 1685], 'overlapping': [1645, 1671], 'synthesized.': [1648], '5′-CGCGGATCCTTTTTTAAAATGGAGTCCGAGACC-3′(forward)': [1653], '5′-CCGGAATTCTCAGTTTGCGATGG-3′(reverse)': [1655], '(the': [1656], 'start': [1657], 'stop': [1659], 'codons': [1660], 'underlined).': [1662], 'To': [1663, 3661], 'produce': [1664], 'D266E': [1668], 'construct': [1669], '5′-AATCGAGATTGGTTGGAATGG-3′(forward)': [1675], '5′-TCCATTCCAACCAATCTCGATTTA-3′': [1677], '(reverse).': [1678, 2105], 'PCR': [1680, 2087, 2108, 2141, 2462], 'products': [1681, 2142], 'contained': [1683, 3412], 'sequence': [1686, 1870, 1996], 'subcloned': [1688, 1708], 'PCR4': [1691], 'TOPO': [1692], 'TA': [1693], 'cloning': [1694], 'vector': [1695], '(Stratagene),': [1696], 'then': [1699, 1946, 2237, 2671, 2700, 3056, 3085, 3109, 3223], 'amplified': [1700], 'digested': [1702, 2473], 'BamHI': [1704], 'EcoRII': [1706], 'pcDNA3.1': [1711], 'vector.': [1712], 'mutation': [1714], 'confirmed': [1716, 3431], 'automated': [1718], 'sequencing': [1720], '(ABI': [1721], 'Prism': [1722], '3700': [1723], 'analyzer).': [1725], 'Transfection': [1726], 'carried': [1731, 2018], 'out': [1732, 2019], 'LipofectAMINE': [1735], 'reagent': [1736, 2056], "manufacturer's": [1739], 'protocol': [1740, 2031], '(Invitrogen).': [1741, 2057, 2077], 'expressing': [1743], 'clones': [1744, 3852, 4156], 'obtained': [1746, 2522, 4138], 'after': [1747, 3025, 3691, 4325], 'selection': [1748], 'growth': [1750], 'presence': [1753, 2621, 2631, 2802, 3212, 3434], 'geneticin': [1755], '(500': [1756], 'mg/liter)': [1757], 'immunoblot': [1764, 2989, 3871], 'analysis.': [1765, 2990], 'Experimental': [1766], 'Treatments—To': [1767], 'undifferentiated': [1771], 'treated': [1775, 4213], 'tunicamycin,': [1777, 4011], 'thapsigargin,': [1778], 'homocysteine,': [1779], '2-mercaptoethanol': [1781, 2441, 3755], '(Sigma)': [1782], 'various': [1784, 4215], 'time': [1785, 3033, 3675, 4019, 4216, 4338, 4379], 'points': [1786, 4217, 4339], 'indicated.': [1788], 'At': [1789], 'end': [1791], 'each': [1793, 2857, 4242, 4302, 4378], 'treatment,': [1794], 'processed': [1797], 'biochemical': [1799], 'analyses': [1800], 'cytoplasmic': [1804], 'proteins,': [1808], 'evaluating': [1811], 'extent': [1813], 'death.': [1816], 'inhibitor': [1819, 2918, 3362, 3735], 'zVAD-fmk': [1820], '(Bio-Mol)': [1821], 'prepared': [1823, 1835, 1890], '500×': [1826], 'stock': [1827, 1840], 'dimethyl': [1829], 'sulfoxide.': [1830], 'Amyloid': [1831], 'β-peptide-(1–42)': [1832], '(Bachem)': [1833], 'water,': [1842], 'incubated': [1845, 2205, 2238, 2369, 2672, 2796, 3057, 3098, 3110, 3206], 'overnight': [1846, 2216], 'room': [1848, 2233, 2602], 'temperature': [1849], 'dilution': [1852, 2693], 'culture': [1854, 2812, 4243], 'medium.': [1855], 'siRNA': [1856, 1880, 1884, 1960, 1977, 2013, 4303, 4310, 4404], 'Preparation': [1857], 'Nucleofection—Several': [1859], '19-base': [1860], '(bp)': [1862], 'sequences': [1863, 1984, 4297], 'selected': [1865, 2000], 'synthesized': [1872, 1981, 2506], 'additional': [1875, 3251], '2-bp': [1876], 'overhang': [1877], 'Construction': [1881], 'kit': [1882, 2076, 2257, 2533], '(Ambion).': [1883], 'duplexes': [1885, 1961, 1978, 4295], 'targeting': [1886, 4304], '(siRNAHerp)': [1888, 4306], 'described.': [1892], '100': [1894, 2363, 2443, 2804], 'nm': [1895, 2805, 2828, 2832], '(5′-AAACAACCGGCTCTTCGTCdTdT-3′': [1898], 'siRNAHerp1;5′-AAUCCUGACUUCCGGGAAAdTdT-3′': [1900], 'siRNAHerp2;': [1902], '5′-AAUCCUGACUUCCGGGAAAdTdT-3′': [1903], 'siRNAHerp3)': [1905], 'corresponding': [1907, 2482], 'antisense': [1908], 'mixed': [1911], '50': [1913], 'μl': [1914], 'water': [1916, 1966], '5': [1918, 1943, 2398, 2401, 2446, 3052, 3100, 4007, 4222, 4332], 'μlof10×': [1919], 'annealing': [1920], 'buffer': [1921, 2383, 2439, 2890, 3228, 3277, 3335], '(0.1': [1922], 'm': [1923], 'potassium': [1924], 'acetate,': [1925], '30': [1926, 2122, 2127, 2798, 3059, 3081, 3112, 3208, 3387], 'HEPES-KOH,': [1928], 'pH': [1929, 2387, 2898, 3244, 3336], '7.2,': [1930], 'magnesium': [1933], 'acetate).': [1934], 'mixture': [1936, 2917], 'heated': [1938], '95': [1940], 'min': [1944, 2112, 2136, 2600, 2799, 2933, 2948, 3060, 3101, 3113, 3209, 3253], 'allowed': [1947, 3247], 'cool': [1949], '25': [1951], 'rate': [1955], '°C/min.': [1958], 'diluted': [1963, 2228], 'RNase-free': [1965], 'stored': [1968], '-80': [1970], 'multiple': [1973], 'aliquots.': [1974], 'Non-silencing': [1975], 'control': [1976, 4309], '(siRNACTRL)': [1979, 4311], 'scrambled': [1983], 'above.': [1987], 'GenBank™': [1988], 'search': [1989], 'revealed': [1990, 3909], 'no': [1991], 'exhibiting': [1995, 4236], 'homology': [1997], 'target': [2001, 4299], 'sequences.': [2002], 'After': [2003, 4086], 'thorough': [2004], 'mixing': [2005], '0.5–1': [2010], 'μg': [2011, 2059, 2364], 'duplexes,': [2014], 'transfection': [2015], 'immediately': [2017], 'Line': [2023], 'Nucleofector': [2024], 'Kit': [2025], 'V': [2026], 'according': [2027], "Amaxa's": [2029], 'optimized': [2030, 2107], 'Mock-transfected': [2035], 'nucleofected': [2038], 'vehicle': [2040], '(water).': [2041], 'Isolation': [2043], 'Reverse': [2045], 'Transcriptase-PCR—Total': [2046], 'extracted': [2049, 2887], 'primary': [2051, 2226, 2262, 2633, 2641, 3687], 'TRIzol': [2055], 'random': [2069], 'first': [2073, 3465], 'strand': [2074], '200': [2078], 'ng': [2079], 'reaction': [2088], 'pairs': [2092], 'primers:': [2094], '5′-GAAGAAGATGAAATAAATCGAGAT-3′(forward)': [2096], '5′-TCAGTTTGCGATGGCTGGGGGG-3′': [2098], '(reverse);': [2099], 'β-actin': [2100], '5′-TGTGATGGACTCCGGTGACGG-3′': [2101], '(forward)': [2102], '5′-ACAGCTTCTCTTTGATGTCACGC-3′': [2104], '94': [2114, 2119], '°C,': [2115, 2426, 2936], '35': [2116], 'cycles': [2117], 's,': [2123, 2128, 2133], '58': [2124], '72': [2129, 2138], '45': [2132], '10': [2135, 2612, 2900, 2932, 3341], '°C.': [2139, 2972], 'separated': [2144], '1.5%': [2147], 'agarose': [2148], 'gel,': [2149], 'stained': [2150, 3920], 'ethidium': [2152], 'bromide,': [2153], 'visualized': [2155, 2252], 'Fuji': [2158], '3000': [2159], 'PhosphorImager.': [2160], 'Immunoblot': [2161], 'Analysis—Methods': [2162], 'quantitation,': [2165], 'electrophoretic': [2166], 'separation,': [2167], 'transfer': [2169], 'nitrocellulose': [2171], 'membranes': [2172, 3036], '(17Chan': [2177], 'Mayne': [2179], 'Holden': [2181], 'C.P.': [2182], '18195-18200Abstract': [2192], '(264)': [2200], 'Membranes': [2203, 2235], 'blocking': [2207, 2230], 'solution': [2208, 2231, 3045, 3089], '(5%': [2209], 'milk': [2210], 'Tween': [2212], 'Tris-buffered': [2213], 'TTBS)': [2215], '4': [2218, 2425, 2935, 2950, 2971], 'followed': [2220, 2614], '1-h': [2223], 'incubation': [2224, 2618, 2628, 3040], 'antibody': [2227, 2244, 2331, 2337, 2348, 3924], 'temperature.': [2234], 'h': [2241, 2423, 2637, 2675, 2969, 3404, 3719, 4015, 4088], 'secondary': [2243, 2690], 'conjugated': [2245], 'horseradish': [2247], 'peroxidase,': [2248], 'bands': [2250], 'chemiluminiscence': [2255], 'detection': [2256, 4344], '(ECL,': [2258], 'Amersham': [2259], 'Biosciences).': [2260], 'antibodies': [2263, 2267, 2313, 2380, 2634, 2642, 2646, 2658, 2691], 'included:': [2264], 'rabbit': [2265, 2377, 2644], 'polyclonal': [2266, 2378, 2645], 'against': [2268, 2314, 2332, 2338, 2349, 2647, 2659, 3811, 4190, 4200], 'Grp78,': [2269, 4350], 'Grp94,': [2270, 2650], 'Hsp60': [2272, 2652], '(StressGen),': [2273], 'β-tubulin,': [2274], 'α-actin': [2276], '(Sigma),': [2277, 2316], 'JNK': [2301], '(C-17,': [2302], 'Santa': [2303, 2321, 2352, 2662], 'Cruz': [2304, 2322, 2353, 2663], 'Biotechnology)': [2305, 2664], 'phospho-c-Jun': [2307], '(Ser63,': [2308], 'Signaling);': [2310], 'mouse': [2311, 2371, 2656, 3472], 'monoclonal': [2312, 2336, 2372, 2657], 'Hsp70': [2315], '(Chemicon),': [2318], 'p-JNK': [2319], '(G7,': [2320], 'Biotechnology),': [2323], 'cytochrome': [2324], 'c': [2325, 2876, 2878], '(PharMingen),': [2326], 'Bcl-2': [2328], '(StressGen);': [2329], 'chicken': [2330], 'calreticulin': [2333], '(ABR);': [2334], '(gift': [2341, 2542], 'Yuan,': [2344], 'Harvard': [2345], 'University);': [2346], 'goat': [2347, 2688], 'c-Jun': [2350], '(sc-45,': [2351], 'Biotechnology).': [2354], 'Immunoprecipitation—Aliquots': [2355], 'lysates': [2358], 'brain': [2360, 3328, 3473, 3591], 'homogenates': [2361, 3594], 'total': [2366, 3996], 'anti-c-Myc,': [2373], 'anti-FLAG': [2374], 'tag,': [2375, 3845], 'anti-Herp': [2379], 'immunoprecipitation': [2382, 2431], '(50': [2384], 'Tris,': [2386], '7.6,': [2388], '150': [2389], 'NaCl,': [2391, 3230], 'EDTA,': [2394, 3352], '1%': [2395], 'Nonidet': [2396], 'P-40,': [2397], 'μg/ml': [2399, 2402, 2405, 4010, 4032, 4333], 'aprotinin,': [2400], 'leupeptin,': [2403], 'pepstatin': [2406], 'A,': [2407], '0.25': [2408], 'phenylmethylsulfonyl': [2410], 'fluoride).': [2411], 'Antigen-antibody': [2412], 'complexes': [2413], 'precipitated': [2415], 'G': [2420], 'washed': [2427, 2701, 2807, 3224], 'three': [2428, 2808, 4253, 4373], 'times': [2429, 2809], 'buffer,': [2432, 3396], 'solubilized': [2434], 'heating': [2436], 'Laemmli': [2438], 'min.': [2447, 3053, 3082, 3388], 'Vitro': [2449], 'Protein': [2450], 'Synthesis': [2451], 'Caspase': [2453, 2991], 'Cleavage—Two': [2454], 'oligonucleotides,': [2455], '5′-GGGGTACCATGGAGTCCGAGACCGAAC-3′': [2456], '5′-CGGAATTCTCAGTTTGCGATGGCTGGG-3′,': [2458], 'amplify': [2463], 'entire': [2465], 'open': [2466], 'reading': [2467], 'frame': [2468], 'Herp.': [2470, 4112], 'product,': [2472], 'KpnI': [2475], 'EcoRI,': [2477], 'ligated': [2479], 'plasmid': [2486, 2498], 'vector,': [2487], 'pZeoSV2(+)': [2488], 'T7': [2492, 2512], 'priming': [2493], 'site.': [2494], 'Using': [2495], 'resultant': [2497], 'DNA,': [2499], 'pZeoSV2Herp,': [2500], 'template,': [2503], 'vitro': [2508, 2525], 'TnT': [2511], 'quick-coupled': [2513], 'transcription/translation': [2514], 'systems': [2515], '(Promega).': [2516], '[35S]Met-labeled': [2517], 'translation': [2528], 'Promega': [2531], 'Coupled': [2532], '(Promega)': [2534], 'subjected': [2536, 2987, 3795], 'purified': [2540], 'caspase-3': [2541], 'Salvesen,': [2545], 'Burnham': [2547], 'Institute)': [2548], '(18Ellerby': [2551, 2747, 3169], 'Hackam': [2553, 2749, 3171], 'Propp': [2555, 2751, 3173], 'S.S.': [2556, 2752, 3174], 'Rabizadeh': [2559, 2755, 3177], 'Cashman': [2561, 2757, 3179], 'N.R.': [2562, 2758, 3180], 'Trifiro': [2563, 2759, 3181], 'Pinsky': [2565, 2761, 3183], 'L.': [2566, 2762, 3184], 'Wellington': [2567, 2763, 3185], 'C.L.': [2568, 2764, 3186], 'Salvesen': [2569, 2765, 3187], 'G.S.': [2570, 2766, 3188], 'Hayden': [2571, 2767, 3189], 'M.R.': [2572, 2768, 3190], '72:': [2578, 2774, 3196], '185-195Crossref': [2579, 2775, 3197], '(204)': [2582, 2778, 3200], 'Immunofluorescence': [2585], 'Confocal': [2586, 3904], 'Microscopy—Following': [2587], 'experimental': [2588, 2869], 'treatments,': [2589], 'fixed': [2592, 3086, 4358], '4%': [2594, 3091], 'paraformaldehyde': [2595, 3092], 'PBS': [2597, 2610, 2677, 3050, 3062, 3094, 3103, 3115], '20': [2599, 2895, 3096, 4009, 4031, 4224], 'temperature,': [2603], 'permeabilized': [2604, 3038], '0.2%': [2606, 3105], 'Triton': [2607, 3106], 'X-100': [2608], 'min,': [2613, 3097], '30-min': [2617], '5%': [2623], 'nonimmune': [2624], 'horse': [2625, 2682], 'serum,': [2626], 'overnight.': [2639], 'included': [2643], '(1:1000),': [2649], '(1:1000,': [2653], 'StressGen),': [2654], '(1:2000,': [2661], '(1:500,': [2667], 'Chemicon).': [2668], 'fluorescein': [2679], 'isothiocyanate': [2680], '(FITC)-labeled': [2681], 'anti-mouse': [2683], 'IgG': [2684], 'Texas': [2686], 'Red-labeled': [2687], 'anti-rabbit': [2689], '(1:50': [2692], 'PBS;': [2695], 'Vector': [2696], 'Laboratories).': [2697], 'images': [2705, 2816, 2861, 3905], 'fluorescence': [2707, 2820, 3123, 3158], 'acquired': [2709, 2822], 'Zeiss': [2712, 3289], 'LSM': [2713], '510': [2714, 2831], 'confocal': [2715, 2815, 2825, 3128], 'laser-scanning': [2716, 3129], 'microscope.': [2717], 'Analyses': [2718], 'Death': [2721], 'Mitochondrial': [2723, 2781], 'Membrane': [2724], 'Potential—Cell': [2725], 'viability': [2726], 'assessed': [2728, 2785, 2996], 'fluorescent': [2731, 2788], 'binding': [2733], 'dye': [2734, 3164], 'Hoechst': [2735], '33342': [2736], 'trypan': [2740], 'blue': [2741], 'exclusion': [2742], 'method': [2743, 2999], 'potential': [2783], 'probe': [2789], 'TMRE': [2790, 2819], '(Molecular': [2791, 3119, 3220], 'Probes).': [2792, 3120], 'TMRE,': [2806], 'fresh': [2811], 'medium,': [2813], 'microscope': [2826, 3291, 3309], '(488': [2827], 'excitation': [2829], 'emission).': [2833], 'average': [2835, 3133, 3303], 'pixel': [2836, 3134], 'intensity': [2837, 3135], 'individual': [2839, 3137], 'bodies': [2841, 3139], 'determined': [2843, 4057], 'software': [2846, 3143], 'supplied': [2847, 3144], 'manufacturer': [2850], '(Zeiss).': [2851], 'Triplicate': [2852], 'condition,': [2858], 'all': [2860], 'coded': [2863], 'analyzed': [2865, 2881, 3605, 3869], 'without': [2866], 'knowledge': [2867], 'treatment': [2870, 3318, 3692], 'history': [2871], 'cultures.': [2874], 'Cytochrome': [2875], 'Release—Cytochrome': [2877], 'Western': [2883], 'blotting.': [2884], 'Proteins': [2885], 'lysis': [2889], '250': [2892, 3344], 'sucrose,': [2894, 3346], 'Hepes,': [2897], '7.5,': [2899], 'KCl,': [2902, 3232, 3343], '1.5': [2903, 3347], 'MgCl2,': [2905, 3236, 3349], 'EGTA,': [2908, 2911, 3355], 'dithiothreitol,': [2914, 3358], 'protease': [2916, 3361], 'set': [2919], '(Roche': [2920], 'Applied': [2921], 'Science).': [2922], 'Homogenates': [2923], 'centrifuged': [2925, 2941, 2962, 3381], 'twice': [2926, 3225], '750': [2928, 3372], '×': [2929, 2944, 2965, 3373, 3384, 3407], 'g': [2930, 2945, 2966, 3385], 'supernatants': [2939, 2959], '10,000': [2943, 3383], '15': [2947], 'isolate': [2953], 'fraction.': [2956, 2979, 3423], 'further': [2961, 3507], '100,000': [2964, 3406], 'remaining': [2974], 'supernatant': [2975, 3377, 3399, 3411], 'represents': [2976], 'cytosolic': [2978, 2984, 3415], 'Both': [2980], 'fractions': [2985, 3603], 'Activity': [2992], 'Measurement—Caspase': [2993], 'activity': [2994], 'exposure': [3026, 3721, 4005, 4090, 4126], 'tunicamycin': [3030, 3726, 4033, 4083, 4096, 4132, 4220], 'designated': [3032], 'periods,': [3034], '0.01%': [3047], 'digitonin': [3048], 'biotinylated': [3064], 'DEVD-CHO': [3065], '(a': [3066], 'substrate': [3067], 'well': [3072], '6,': [3075], '7,': [3076], '8,': [3077], '10)': [3079], 'X-100,': [3107], 'Oregon': [3117], 'green-streptavidin': [3118], 'Images': [3121], 'captured': [3125], 'microscope,': [3130], 'measured': [3141], 'manufacturer.': [3147], 'Calcium': [3148], 'Imaging—Levels': [3149], 'intracellular': [3151], 'free': [3152], '([Ca2+]i)': [3154], 'quantified': [3156, 3312], 'imaging': [3159, 3271, 3300], 'calcium': [3162], 'indicator': [3163], 'fura-2': [3165, 3219], 'μm': [3215, 3282], 'acetoxymethylester': [3216], 'Probes)': [3221], "Locke's": [3227, 3276], '(mm:': [3229], '154;': [3231], '5.6;': [3233], 'CaCl2,': [3234], '2.3;': [3235], '1.0;': [3237], 'NaHCO3,': [3238], '3.6;': [3239], 'glucose,': [3240], '10;': [3241], 'Hepes': [3242], '5,': [3243], '7.2)': [3245], 'incubate': [3249], '20–30': [3252], 'allow': [3255], 'complete': [3256], 'deesterification': [3257], 'dye.': [3260], 'Measurement': [3261], 'content': [3265], 'washing': [3269], 'Ca2+-free': [3275], 'upon': [3278], 'addition': [3279], 'thapsigargin.': [3283], 'imaged': [3286], 'Axiovert': [3290], '(×40': [3292], 'oil': [3293], 'immersion': [3294], 'objective)': [3295], 'coupled': [3296], 'Attofluor': [3299], 'system.': [3301], '[Ca2+]i': [3304], '40–60': [3306], 'per': [3308, 3317, 4375], 'field': [3310], 'four': [3314], 'separate': [3315], 'condition.': [3319], 'Subcellular': [3320], 'Fractionation—Pellets': [3321], 'frozen': [3323], 'tissues': [3329], 'homogenized': [3331], 'ice-cold': [3333], 'fractionation': [3334, 3395], '7.4': [3337], '(20': [3338, 4097], 'HEPES,': [3340], 'mixture).': [3363], 'Nuclei': [3364], 'pelleted': [3366], '10-min': [3369], 'spin': [3370], 'g,': [3374], 'recovered': [3379], 'pellet': [3391, 3419], 'resuspended': [3393], 'recentrifuged': [3401], 'g.': [3408], 'soluble': [3414, 3602], 'fraction,': [3416], 'constituted': [3420], 'microsomal': [3422, 3428, 3616], 'purity': [3425], 'fraction': [3429, 3617], 'grp94,': [3436], 'lumen': [3439], 'protein.': [3440, 3981], 'Is': [3442], 'Present': [3443], 'Developing': [3449], 'Adult': [3451], 'Brain': [3452, 3593], 'Its': [3454], 'Levels': [3455], 'Are': [3456], 'Markedly': [3457], 'Increased': [3458], 'Neurons': [3460, 4412], 'Subjected': [3461], 'Stress—We': [3464], 'examined': [3466, 3673], 'development.': [3475, 3560], 'relatively': [3480], 'high': [3481], 'cortex': [3486, 3528], 'embryonic': [3488], 'development': [3489], 'ages': [3491], 'E11': [3492, 3545], 'E15,': [3494], 'decreased': [3497, 3506], 'between': [3498], 'E15': [3499], 'postnatal': [3501, 3547], '2,': [3503], 'mice': [3510], '(Fig.': [3511, 3579, 3608, 3746, 3752, 3849, 3902, 3934, 4016, 4084, 4149], '1A).': [3512], 'developmental': [3514], 'constitutive': [3517], 'similar': [3521, 3571], 'seen': [3524], 'occurred': [3530], 'hippocampus': [3533, 3576], 'cerebellum': [3535, 3578], '(data': [3536, 3756, 3802, 4183], 'shown).': [3538, 3804], 'differential': [3540], 'suggests': [3550], 'play': [3554], 'important': [3556], 'CNS': [3559], 'mouse,': [3566], 'cortex,': [3575], '1B).': [3580], 'Next,': [3581], 'investigated': [3583], 'subcellular': [3585, 3866], 'localization': [3586, 3867, 3910], 'fractionated': [3596], 'nuclear,': [3598], 'mitochondrial,': [3599], 'microsomal,': [3600], 'immunoblotting': [3607, 4354], '1C).': [3609], 'predominantly': [3612], 'found': [3613], 'along': [3618], 'grp94': [3620], 'that,': [3622], 'case': [3626], 'ER-resident': [3656], 'determine': [3662, 3816], 'neurons,': [3671, 3713], 'course': [3676], 'mRNA': [3681, 3703], 'agents': [3694, 3759], 'Basal': [3699], 'very': [3707], 'low': [3708], 'increased': [3715, 4044], 'rapidly': [3716], 'within': [3717, 3775], '6': [3718, 3776], 'subtoxic': [3724, 4129], 'concentration': [3725, 4094, 4130], '(an': [3727, 3734], 'agent': [3728], 'inhibits': [3730], 'N-glycosylation)': [3731], 'thapsigargin': [3733, 4140, 4228], 'Ca2+-ATPase': [3739], 'induces': [3741, 3800], 'depletion': [3742], 'Ca2+)': [3745], '1,': [3747], 'D': [3748], 'E).': [3750], 'Homocysteine': [3751], '1D)': [3753], 'shown),': [3758], 'redox': [3763], 'environment': [3764], 'elevation': [3771], 'h.': [3777], 'specific': [3783], 'because': [3787, 3968], 'did': [3790, 3963], 'serum': [3797, 4181], 'deprivation,': [3798], 'Overexpression': [3805], 'Protects': [3808], 'Stress-induced': [3813, 4415], 'Death—To': [3815], 'consequences': [3818], 'overexpressed': [3832], 'Herp-tagged': [3835], '2A).': [3850], 'Several': [3851], 'stably': [3853, 3887], 'overexpressing': [3854, 4111, 4157], 'selected,': [3857], 'level': [3860, 3896], 'immunocytochemical': [3873], 'analyses.': [3874], 'tagged': [3880], '(t-Herp)': [3882], 'extracts': [3885], 'transfected': [3888, 4396], '4–8-fold': [3891], 'endogenous': [3895, 4346], 'VT': [3900, 4062, 4071, 4102, 4271], '2B).': [3903], 'immunoreactivity': [3908], 'reticular': [3912], 'structures': [3913], 'cytoplasm,': [3916], 'anti-grp94': [3923], 'demonstrating': [3925], 'mainly': [3929], '2C)': [3935], 'reported': [3938], 'tags': [3962], 'affect': [3965], 'localization,': [3967], 'staining': [3970], 'pattern': [3971], 't-Herp': [3973], 'identical': [3975], 'untagged': [3980], 'ectopic': [3985], 'approximately': [3991], '2–6-fold': [3992], 'inducible': [3997], 'achieved': [4001], 'respectively,': [4012], '2D),': [4017], 'point': [4020], '80%': [4025], 'exposed': [4029, 4330], 'still': [4035], 'viable': [4036], '(see': [4037], 'Fig.': [4039], '3A).': [4040, 4085], 'effect': [4042], 'vulnerability': [4049], 'exposing': [4059], 'Herp-overexpressing': [4060, 4073, 4113, 4209], 'increasing': [4065], 'concentrations': [4066], 'tunicamycin.': [4068], 'Compared': [4069], 'significantly': [4076], 'more': [4077, 4117, 4163, 4175], 'resistant': [4078, 4118, 4164, 4176], '24': [4087], 'toxic': [4093], 'μg/ml),': [4098], '77%': [4099], 'apoptotic': [4105, 4362], 'compared': [4106, 4269, 4390], '42%': [4108], 'prolonged': [4125], '(5': [4133], 'μg/ml).': [4134], 'Similar': [4135], 'when': [4139], '(100': [4141, 4229], 'nm)': [4142], 'applied': [4144], 'stressor': [4148], '3B).': [4150], 'tested': [4153], 'they': [4160], 'consistently': [4162], 'withdrawal': [4182], 'shown).Fig.': [4185], '3Herp': [4186], 'protects': [4187, 4199], 'apoptosis.A': [4193], 'B,': [4195], 'Cultures': [4204], 'vector-transfected': [4206], '(VT)': [4207], '(A)': [4219], '(Tun;': [4221], 'μg/ml)': [4225], '(B)': [4227], 'nm),': [4230], 'percentage': [4233], 'condensed': [4237], 'fragmented': [4239], 'nuclei': [4240], 'quantified.': [4245], 'Values': [4246, 4366], 'means': [4249, 4369], 'S.D.': [4251, 4371], 'independent': [4254], 'experiments.': [4255], '*,': [4256, 4381], 'p': [4257, 4261, 4382], '<': [4258, 4262, 4383], '0.01;': [4259], '**,': [4260], '0.005': [4263], '(ANOVA': [4264, 4385], 'Scheffe': [4266, 4387], 'post-hoc': [4267, 4388], 'tests)': [4268, 4389], 'C': [4274], 'D,': [4276], 'ER-stress': [4288], 'Small': [4291], 'interfering': [4292], '(siRNA)': [4294], '(for': [4296], 'mRNAs': [4300], 'nonsilencing': [4308], 'see': [4312], '"Experimental': [4313], 'Procedures")': [4314], 'delivered': [4316], 'naive': [4318], 'nucleofection.': [4322], 'One': [4323], 'nucleofection,': [4326], 'Tun': [4334], 'indicated': [4337], 'subsequently': [4341], 'harvested': [4342], 'Grp94': [4352], '(C)': [4356], 'quantitation': [4360], '(D).': [4365], 'group': [4376], 'point.': [4380], '0.01': [4384], 'mock-transfected': [4392], 'siRNACTRL.View': [4398], 'Large': [4399], 'Image': [4400], 'Figure': [4401], 'ViewerDownload': [4402], '(PPT)': [4403], 'Inhibition': [4405], 'Expression': [4408], 'Increases': [4409], 'Vulnerability': [4410], 'Death—If': [4417], 'critical': [4428], 'maintaining': [4430], 'surv': [4432]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1965650841', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2025-01-20T11:59:54.716411', 'created_date': '2016-06-24'}
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