Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1965636722', 'doi': 'https://doi.org/10.1039/c4bm00223g', 'title': 'Enhanced proteotoxic stress: one of the contributors for hyperthermic potentiation of the proteasome inhibitor bortezomib using magnetic nanoparticles', 'display_name': 'Enhanced proteotoxic stress: one of the contributors for hyperthermic potentiation of the proteasome inhibitor bortezomib using magnetic nanoparticles', 'publication_year': 2014, 'publication_date': '2014-10-16', 'ids': {'openalex': 'https://openalex.org/W1965636722', 'doi': 'https://doi.org/10.1039/c4bm00223g', 'mag': '1965636722', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/26218130'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1039/c4bm00223g', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2494179437', 'display_name': 'Biomaterials Science', 'issn_l': '2047-4830', 'issn': ['2047-4830', '2047-4849'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320556', 'host_organization_name': 'Royal Society of Chemistry', 'host_organization_lineage': ['https://openalex.org/P4310320556'], 'host_organization_lineage_names': ['Royal Society of Chemistry'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5044954178', 'display_name': 'Merlis P. Alvarez-Berríos', 'orcid': 'https://orcid.org/0000-0001-7543-1129'}, 'institutions': [{'id': 'https://openalex.org/I200399037', 'display_name': 'University of Puerto Rico System', 'ror': 'https://ror.org/02yg0nm07', 'country_code': 'PR', 'type': 'education', 'lineage': ['https://openalex.org/I200399037']}], 'countries': ['PR'], 'is_corresponding': False, 'raw_author_name': 'Merlis P. Alvarez-Berrios', 'raw_affiliation_strings': ['Department of Chemical Engineering', 'Mayagüez', 'University of Puerto Rico'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemical Engineering', 'institution_ids': []}, {'raw_affiliation_string': 'University of Puerto Rico', 'institution_ids': ['https://openalex.org/I200399037']}, {'raw_affiliation_string': 'Mayagüez', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5106133041', 'display_name': 'Amalchi Castillo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200399037', 'display_name': 'University of Puerto Rico System', 'ror': 'https://ror.org/02yg0nm07', 'country_code': 'PR', 'type': 'education', 'lineage': ['https://openalex.org/I200399037']}], 'countries': ['PR'], 'is_corresponding': False, 'raw_author_name': 'Amalchi Castillo', 'raw_affiliation_strings': ['Department of Chemical Engineering', 'Mayagüez', 'University of Puerto Rico'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemical Engineering', 'institution_ids': []}, {'raw_affiliation_string': 'University of Puerto Rico', 'institution_ids': ['https://openalex.org/I200399037']}, {'raw_affiliation_string': 'Mayagüez', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004727296', 'display_name': 'Fernando Mérida', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200399037', 'display_name': 'University of Puerto Rico System', 'ror': 'https://ror.org/02yg0nm07', 'country_code': 'PR', 'type': 'education', 'lineage': ['https://openalex.org/I200399037']}], 'countries': ['PR'], 'is_corresponding': False, 'raw_author_name': 'Fernando Merida', 'raw_affiliation_strings': ['Department of Chemical Engineering', 'Mayagüez', 'University of Puerto Rico'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemical Engineering', 'institution_ids': []}, {'raw_affiliation_string': 'University of Puerto Rico', 'institution_ids': ['https://openalex.org/I200399037']}, {'raw_affiliation_string': 'Mayagüez', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003161080', 'display_name': 'Janet Méndez', 'orcid': 'https://orcid.org/0000-0002-0915-5274'}, 'institutions': [{'id': 'https://openalex.org/I200399037', 'display_name': 'University of Puerto Rico System', 'ror': 'https://ror.org/02yg0nm07', 'country_code': 'PR', 'type': 'education', 'lineage': ['https://openalex.org/I200399037']}], 'countries': ['PR'], 'is_corresponding': False, 'raw_author_name': 'Janet Mendez', 'raw_affiliation_strings': ['Department of Chemical Engineering', 'Mayagüez', 'University of Puerto Rico'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemical Engineering', 'institution_ids': []}, {'raw_affiliation_string': 'University of Puerto Rico', 'institution_ids': ['https://openalex.org/I200399037']}, {'raw_affiliation_string': 'Mayagüez', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000695073', 'display_name': 'Carlos Rinaldi', 'orcid': 'https://orcid.org/0000-0001-8886-5612'}, 'institutions': [{'id': 'https://openalex.org/I33213144', 'display_name': 'University of Florida', 'ror': 'https://ror.org/02y3ad647', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I33213144']}, {'id': 'https://openalex.org/I4210147789', 'display_name': 'Gainesville Obstetrics & Gynecology', 'ror': 'https://ror.org/04e7afm38', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210147789']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Carlos Rinaldi', 'raw_affiliation_strings': ['Department of Chemical Engineering', 'Department of Chemical Engineering, University of Florida, Gainesville, FL, USA', 'Gainesville', 'J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA'], 'affiliations': [{'raw_affiliation_string': 'J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA', 'institution_ids': ['https://openalex.org/I33213144']}, {'raw_affiliation_string': 'Department of Chemical Engineering, University of Florida, Gainesville, FL, USA', 'institution_ids': ['https://openalex.org/I33213144']}, {'raw_affiliation_string': 'Department of Chemical Engineering', 'institution_ids': []}, {'raw_affiliation_string': 'Gainesville', 'institution_ids': ['https://openalex.org/I4210147789']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5110281833', 'display_name': 'Madeline Torres-Lugo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200399037', 'display_name': 'University of Puerto Rico System', 'ror': 'https://ror.org/02yg0nm07', 'country_code': 'PR', 'type': 'education', 'lineage': ['https://openalex.org/I200399037']}], 'countries': ['PR'], 'is_corresponding': True, 'raw_author_name': 'Madeline Torres-Lugo', 'raw_affiliation_strings': ['Department of Chemical Engineering', 'Mayagüez', 'University of Puerto Rico'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemical Engineering', 'institution_ids': []}, {'raw_affiliation_string': 'University of Puerto Rico', 'institution_ids': ['https://openalex.org/I200399037']}, {'raw_affiliation_string': 'Mayagüez', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5110281833'], 'corresponding_institution_ids': ['https://openalex.org/I200399037'], 'apc_list': None, 'apc_paid': None, 'fwci': 0.65, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 14, 'citation_normalized_percentile': {'value': 0.614436, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 88, 'max': 89}, 'biblio': {'volume': '3', 'issue': '2', 'first_page': '391', 'last_page': '400'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10063', 'display_name': 'Nanoparticle-Based Drug Delivery', 'score': 0.9795, 'subfield': {'id': 'https://openalex.org/subfields/2502', 'display_name': 'Biomaterials'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10063', 'display_name': 'Nanoparticle-Based Drug Delivery', 'score': 0.9795, 'subfield': {'id': 'https://openalex.org/subfields/2502', 'display_name': 'Biomaterials'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11150', 'display_name': 'Endoplasmic Reticulum Stress and Disease', 'score': 0.978, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12505', 'display_name': 'Peptidase Inhibition and Analysis', 'score': 0.9419, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/hsp90-inhibitor', 'display_name': 'Hsp90 inhibitor', 'score': 0.43013194}], 'concepts': [{'id': 'https://openalex.org/C2777478702', 'wikidata': 'https://www.wikidata.org/wiki/Q419319', 'display_name': 'Bortezomib', 'level': 3, 'score': 0.83882225}, {'id': 'https://openalex.org/C2778367456', 'wikidata': 'https://www.wikidata.org/wiki/Q7251235', 'display_name': 'Proteasome inhibitor', 'level': 3, 'score': 0.777154}, {'id': 'https://openalex.org/C27740335', 'wikidata': 'https://www.wikidata.org/wiki/Q14878333', 'display_name': 'Proteasome', 'level': 2, 'score': 0.6280911}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.599045}, {'id': 'https://openalex.org/C109316439', 'wikidata': 'https://www.wikidata.org/wiki/Q246181', 'display_name': 'Cytotoxicity', 'level': 3, 'score': 0.592767}, {'id': 'https://openalex.org/C139447449', 'wikidata': 'https://www.wikidata.org/wiki/Q14633900', 'display_name': 'Unfolded protein response', 'level': 3, 'score': 0.5497329}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.49533167}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.43057263}, {'id': 'https://openalex.org/C2777560012', 'wikidata': 'https://www.wikidata.org/wiki/Q5924361', 'display_name': 'Hsp90 inhibitor', 'level': 5, 'score': 0.43013194}, {'id': 'https://openalex.org/C87023908', 'wikidata': 'https://www.wikidata.org/wiki/Q3870166', 'display_name': 'Magnetic nanoparticles', 'level': 3, 'score': 0.42977595}, {'id': 'https://openalex.org/C25274449', 'wikidata': 'https://www.wikidata.org/wiki/Q1805481', 'display_name': 'Long-term potentiation', 'level': 3, 'score': 0.41152123}, {'id': 'https://openalex.org/C155672457', 'wikidata': 'https://www.wikidata.org/wiki/Q61231', 'display_name': 'Nanoparticle', 'level': 2, 'score': 0.41073576}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.38870823}, {'id': 'https://openalex.org/C2775932338', 'wikidata': 'https://www.wikidata.org/wiki/Q24772687', 'display_name': 'Hsp90', 'level': 4, 'score': 0.38028866}, {'id': 'https://openalex.org/C205260736', 'wikidata': 'https://www.wikidata.org/wiki/Q418939', 'display_name': 'Heat shock protein', 'level': 3, 'score': 0.31148458}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.1739009}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.17052498}, {'id': 'https://openalex.org/C158617107', 'wikidata': 'https://www.wikidata.org/wiki/Q79927', 'display_name': 'Endoplasmic reticulum', 'level': 2, 'score': 0.16779366}, {'id': 'https://openalex.org/C171250308', 'wikidata': 'https://www.wikidata.org/wiki/Q11468', 'display_name': 'Nanotechnology', 'level': 1, 'score': 0.1452241}, {'id': 'https://openalex.org/C192562407', 'wikidata': 'https://www.wikidata.org/wiki/Q228736', 'display_name': 'Materials science', 'level': 0, 'score': 0.13146403}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.12967941}, {'id': 'https://openalex.org/C2776364478', 'wikidata': 'https://www.wikidata.org/wiki/Q467635', 'display_name': 'Multiple myeloma', 'level': 2, 'score': 0.08516607}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.08254048}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000069286', 'descriptor_name': 'Bortezomib', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D006979', 'descriptor_name': 'Hyperthermia, Induced', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D058185', 'descriptor_name': 'Magnetite Nanoparticles', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D061988', 'descriptor_name': 'Proteasome Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000069286', 'descriptor_name': 'Bortezomib', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002470', 'descriptor_name': 'Cell Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006979', 'descriptor_name': 'Hyperthermia, Induced', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061986', 'descriptor_name': 'MCF-7 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058185', 'descriptor_name': 'Magnetite Nanoparticles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061988', 'descriptor_name': 'Proteasome Inhibitors', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D061988', 'descriptor_name': 'Proteasome Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1039/c4bm00223g', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2494179437', 'display_name': 'Biomaterials Science', 'issn_l': '2047-4830', 'issn': ['2047-4830', '2047-4849'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320556', 'host_organization_name': 'Royal Society of Chemistry', 'host_organization_lineage': ['https://openalex.org/P4310320556'], 'host_organization_lineage_names': ['Royal Society of Chemistry'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/26218130', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Clean water and sanitation', 'id': 'https://metadata.un.org/sdg/6', 'score': 0.59}], 'grants': [{'funder': 'https://openalex.org/F4320306076', 'funder_display_name': 'National Science Foundation', 'award_id': 'HRD-0833112'}], 'datasets': [], 'versions': [], 'referenced_works_count': 32, 'referenced_works': ['https://openalex.org/W1489233729', 'https://openalex.org/W1944289918', 'https://openalex.org/W1969802936', 'https://openalex.org/W1970476711', 'https://openalex.org/W1987204200', 'https://openalex.org/W1987338737', 'https://openalex.org/W1998916177', 'https://openalex.org/W2000144812', 'https://openalex.org/W2005485591', 'https://openalex.org/W2009973031', 'https://openalex.org/W2010708627', 'https://openalex.org/W2032747584', 'https://openalex.org/W2043402257', 'https://openalex.org/W2047744526', 'https://openalex.org/W2053812062', 'https://openalex.org/W2064347067', 'https://openalex.org/W2069247663', 'https://openalex.org/W2076232417', 'https://openalex.org/W2085426819', 'https://openalex.org/W2091905777', 'https://openalex.org/W2112410898', 'https://openalex.org/W2113915760', 'https://openalex.org/W2118536708', 'https://openalex.org/W2131442970', 'https://openalex.org/W2132834292', 'https://openalex.org/W2149761960', 'https://openalex.org/W2156124327', 'https://openalex.org/W2170558349', 'https://openalex.org/W2315718304', 'https://openalex.org/W2318096931', 'https://openalex.org/W2328138807', 'https://openalex.org/W4302336825'], 'related_works': ['https://openalex.org/W4281831295', 'https://openalex.org/W3146265467', 'https://openalex.org/W3032571198', 'https://openalex.org/W3029266790', 'https://openalex.org/W3028919400', 'https://openalex.org/W2105502495', 'https://openalex.org/W2053506257', 'https://openalex.org/W2039856481', 'https://openalex.org/W1973074169', 'https://openalex.org/W1732928399'], 'abstract_inverted_index': {'The': [0], 'induction': [1], 'of': [2, 22, 70, 79, 125, 158, 173, 183], 'hyperthermia': [3, 10, 53], 'using': [4], 'nanoparticles,': [5], 'known': [6], 'as': [7], 'magnetic': [8], 'fluid': [9], '(MFH)': [11], 'in': [12, 76, 176], 'combination': [13, 69], 'with': [14, 36], 'anti-cancer': [15, 27], 'drugs': [16], 'is': [17, 167], 'an': [18, 74], 'attractive': [19], 'method': [20], 'because': [21], 'the': [23, 42, 56, 77, 132, 137, 159, 168, 177, 181, 187], 'potential': [24], 'for': [25, 86, 109], 'enhanced': [26, 63], 'effects.': [28], 'Recent': [29], 'studies': [30, 118], 'have': [31], 'shown': [32], 'that': [33, 62, 156, 196], 'cells': [34, 48, 94], 'treated': [35, 49], 'MFH': [37, 163, 197], 'are': [38], 'more': [39, 200], 'sensitive': [40], 'to': [41, 97, 130, 180, 186], 'proteasome': [43], 'inhibitor': [44], 'bortezomib': [45], '(BZ)': [46], 'than': [47, 206], 'by': [50, 67, 136, 161], 'hot': [51], 'water': [52], '(HWH)': [54], 'under': [55, 208], 'same': [57], 'temperature': [58, 210], 'conditions.': [59, 211], 'We': [60], 'hypothesized': [61], 'proteotoxic': [64, 204], 'stress,': [65], 'caused': [66], 'a': [68, 199], 'microtubule': [71, 116, 152], 'damage': [72], 'and': [73, 115, 144, 151, 170, 202], 'increase': [75], 'amount': [78], 'aggregated': [80, 174], 'proteins,': [81], 'may': [82], 'be': [83], 'partially': [84], 'responsible': [85], 'this': [87, 91], 'observation.': [88], 'To': [89], 'test': [90], 'hypothesis': [92], 'MCF-7': [93], 'were': [95, 128], 'exposed': [96], 'hyperthermic': [98], 'treatment': [99], '(MFH': [100], 'or': [101, 106, 122], 'HWH)': [102], 'at': [103, 119, 142], '43': [104], '°C': [105, 108], '45': [107], '30': [110, 120], 'minutes.': [111], 'Then,': [112], 'aggresome': [113], 'formation': [114, 150, 169], 'disruption': [117, 153], 'minutes': [121], '2.5': [123], 'hours': [124], 'recovery': [126], 'time': [127], 'performed': [129], 'evaluate': [131], 'progressive': [133], 'effects': [134], 'induced': [135], 'two': [138], 'treatments.': [139], 'Cell': [140], 'viability': [141], 'short': [143], 'long': [145], 'times': [146], 'was': [147], 'evaluated.': [148], 'Aggresome': [149], 'results': [154], 'suggested': [155], 'one': [157], 'mechanisms': [160], 'which': [162], 'enhances': [164], 'BZ': [165], 'cytotoxicity': [166], 'subsequent': [171], 'accumulation': [172], 'proteins': [175], 'cytosol': [178], 'due': [179], 'interruption': [182], 'their': [184], 'transport': [185], 'perinuclear': [188], 'area': [189], 'through': [190], 'microtubules.': [191], 'Our': [192], 'data': [193], 'show': [194], 'evidence': [195], 'induces': [198], 'toxic': [201], 'unmitigated': [203], 'stress': [205], 'HWH': [207], 'similar': [209]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1965636722', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 3}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}], 'updated_date': '2024-12-12T23:14:25.489123', 'created_date': '2016-06-24'}