Enhanced acid stability of a reduced nicotinamide adenine dinucleotide (NADH) analogue

Name: Work Video:
Duration: 3 min 30 s
Description: A methyl substituent at C-5 of the nicotinamide ring is found to confer increased acid stability in a reduced nicotinamide model (5–20 fold) and in a reduced dinucleotide coenzyme (2–3 fold), while retaining reactivity towards hydride transfer.
Philip L. Hentall; Nadine Flowers; Timothy D. H. Bugg
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