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'system': [25], 'penetration,': [26], 'we': [27], 'measured': [28], 'raltegravir': [29, 92, 97, 107, 115, 157], 'concentrations': [30, 48, 93, 116, 161], 'cerebrospinal': [32], 'fluid': [33], '(CSF)': [34], 'and': [35, 61, 78, 122, 171], 'plasma': [36, 62, 106], 'subjects': [38], 'receiving': [39], 'antiretroviral': [40], 'treatment': [41], 'regimens': [42], 'containing': [43], 'this': [44], 'drug.': [45], 'Methods': [46], 'were': [49], 'determined': [50], 'by': [51], 'liquid': [52], 'chromatography': [53], 'tandem': [54], 'mass': [55], 'spectrometry': [56], '25': [58, 87], 'paired': [59], 'CSF': [60, 77, 88, 114, 123, 131, 163], 'samples': [63, 89], 'from': [64], '16': [65], 'individuals.': [67], 'The': [68, 104], 'lower': [69], 'limit': [70], 'of': [71, 85, 99, 129, 153, 181], 'quantitation': [72], 'was': [73, 109], '2.0': [74], 'ng/ml': [75, 80, 101, 111], 'for': [76, 81], '10': [79], 'plasma.': [82], 'Results': [83], 'Twenty-four': [84], 'the': [86, 130, 134], 'had': [90], 'detectable': [91], 'with': [94, 118], 'a': [95], 'median': [96, 105], 'concentration': [98, 108], '18.4': [100], '(range,': [102, 112], '<2.0–126.0).': [103], '448': [110], '37–5180).': [113], 'correlated': [117], 'CSF:plasma': [119], 'albumin': [120, 124], 'ratios': [121], 'concentrations.': [125], 'Conclusions': [126], 'Approximately': [127], '50%': [128], 'specimens': [132], 'exceeded': [133], 'IC95': [135], 'levels': [136], 'reported': [137], 'inhibit': [139], 'strains': [141], 'without': [142], 'resistance': [143], 'inhibitors.': [146], 'addition': [148], 'contributing': [150], 'control': [152], 'systemic': [154], 'infection,': [156], 'achieves': [158], 'local': [159], 'inhibitory': [160], 'most,': [165], 'but': [166], 'not': [167], 'all,': [168], 'patients.': [169], 'Blood-brain': [170], 'blood-CSF': [172], 'barriers': [173, 183], 'likely': [174], 'restrict': [175], 'entry,': [177], 'while': [178], 'enhanced': [179], 'permeability': [180], 'these': [182], 'enhances': [184], 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