Publication Information

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269, 282, 302, 312, 533, 627, 661, 847, 855, 1064, 1076, 1142, 1178, 1204, 1212, 1238, 1258, 1273, 1278, 1347, 1380, 1408, 1412, 1422, 1434, 1516, 1542, 1548, 1568, 1639, 1696, 1739, 1790, 1798, 1812, 1820, 1851, 1919, 1928, 1952, 1986, 1993, 2078, 2106, 2124, 2146, 2170, 2226, 2240, 2310, 2326, 2406, 2419, 2439, 2456, 2471, 2536, 2548, 2570, 2597, 2601, 2606, 2616, 2622, 2780, 2840, 2892, 2937, 2965, 2991, 3002, 3081, 3086, 3091, 3132, 3143, 3145, 3153, 3177, 3228, 3249, 3355, 3375, 3407, 3421, 3432, 3444, 3465, 3483, 3485, 3503, 3507, 3527, 3561, 3563, 3655, 3666, 3731, 4019, 4054, 4071, 4099, 4117, 4185, 4253, 4337, 4415, 4747, 4852, 4913, 4958, 5010, 5013, 5022, 5045, 5065, 5076, 5078, 5081, 5153, 5170], 'reversible': [44, 196], 'phosphorylation': [47, 147, 199, 299, 1161, 1557, 1679, 1760, 1770, 1784, 1845, 1964, 2140, 2221, 2232, 2391, 2518, 2921, 3094, 3196, 3205, 3260, 3269, 3306, 3456, 3633, 3698, 3724, 4145, 4234, 4258, 4368, 4915, 5041], 'on': [48, 200, 1559, 2142, 2157, 2183, 2866, 3271, 3536, 3679, 3998, 4274, 4342, 4493], 'three': [49, 201, 1563, 1682, 1686, 1765, 2132, 2138, 2165, 3275, 3673, 4089], 'proline-directed': [50, 202, 1564, 1683, 3674], 'sites': [51, 203, 1558, 1565, 1684, 1766, 2141, 3277], '(Ser-202,': [52, 204, 1566], 'Thr-181,': [53, 205, 1567], 'Thr-231)': [55, 207, 1569], 'systems': [57, 209, 1170, 3107, 3553], 'enriched': [58, 210, 315, 1073, 1854], 'α7': [60, 212, 329, 663], 'nicotinic': [61, 213, 330, 664, 2322], 'acetylcholine': [62, 214, 331, 665], 'receptors': [63, 215, 666, 4525, 5136], '(α7nAChR)': [64, 216, 667], 'including': [65, 217, 1174, 2740, 3247, 3557], 'serum-deprived': [66, 218, 1701, 2477, 2583, 2867, 2928, 3112, 4150], 'human': [67, 219, 1175, 1200, 1207, 1702, 1905, 1920, 1989, 2237, 2566, 3558, 3564], 'SK-N-MC': [68, 220, 1236, 1704, 2055, 2223, 2234, 2286, 2424, 2478, 2868, 2929, 3113, 3415, 3469], 'neuroblastoma': [69, 221, 1176, 1703, 3559], 'cells': [70, 90, 222, 242, 1177, 1237, 1263, 1705, 1992, 2056, 2101, 2287, 2425, 2479, 2521, 2581, 2869, 2930, 3114, 3416, 3470, 3560, 4148, 4166, 4652], 'hippocampal': [72, 224, 562, 1852, 5082], 'synaptosomes.': [73, 225, 1180], 'Although': [74, 226, 2482, 3215, 4011, 4456], 'α7nAChR': [75, 87, 141, 227, 239, 293, 761, 1004, 1067, 1173, 1185, 1201, 1708, 1856, 1980, 2004, 2248, 2270, 2292, 2359, 2399, 2449, 2461, 2505, 2512, 2551, 2605, 3220, 3253, 3390, 3480, 3556, 3639, 3685, 3896, 4022, 4215, 4226, 4283, 4343, 4481, 4497, 4529, 4883, 4943, 5030, 5090], 'agonists': [76, 228, 2400], 'induced': [77, 229, 1759, 1968, 2219, 3725], 'similar': [78, 230, 2044, 2620, 2949, 3098, 5061], 'phosphorylation,': [79, 231, 638, 2275, 2861, 2954, 3164], 'pretreatment': [80, 232], 'with': [81, 233, 632, 923, 1070, 1243, 1382, 1397, 1480, 1737, 1773, 2081, 2104, 2290, 2611, 2871, 3068, 3118, 3417, 3473, 3489, 3498, 3893, 3898, 4021, 4052, 4104, 4213, 4371, 4472, 4535, 4849, 5056], 'antisense-α7nAChR': [82, 234, 2436, 3418], 'oligonucleotides': [83, 235, 1198], '(in': [84, 89, 236, 241], 'cells)': [85, 237], 'or': [86, 238, 412, 1384, 1487, 1902, 1941, 1971, 2000, 2295, 2538, 2609, 2911, 2927, 3105, 3474, 3501, 3641, 3676, 3897, 4094, 4526], 'antagonists': [88, 240], 'synaptosomes)': [92, 244], 'attenuated': [93, 245, 2312, 2388, 3637], 'Aβ-induced': [94, 123, 144, 246, 275, 296, 3696, 4245], 'Western': [97, 249, 1352, 1425, 1549, 1752, 2125, 2467, 2623, 2862, 3059, 3508, 5094], 'analyses': [98, 250, 1426, 1550, 1754, 2624, 2863, 3358, 5095], 'showed': [99, 251, 1755, 2307, 3077], 'mitogen-activated': [102, 254, 338, 755, 792, 2781, 4781], 'kinase': [103, 110, 120, 255, 262, 272, 342, 756, 793, 804, 2743, 2782, 2888, 2906, 3123, 3169, 3172, 3347, 3524, 4782], 'cascade': [104, 256, 757, 794, 2783, 4181, 4783], 'proteins,': [105, 257], 'ERKs': [106, 129, 149, 258, 281, 301, 2946, 2956, 2968, 2984, 2994, 3071, 3191, 3248, 3263, 3433, 3445, 3464, 3654, 5044, 5064], 'c-Jun': [108, 260, 347, 3345], 'N-terminal': [109, 261, 348, 3346], '(JNK-1),': [111, 263], 'were': [112, 264, 1218, 1232, 1281, 1295, 1310, 1356, 1540, 1745, 1801, 1913, 2057, 2102, 2288, 2441, 2522, 2582, 2632, 2864, 2957, 3115, 3155, 3179, 3471, 3496, 3512, 4149], 'concomitantly': [113, 265, 3658], 'activated': [114, 266, 1485, 1492, 2959, 2967, 3070, 3296, 3367, 3376, 3394, 3519, 3659], 'by': [115, 267, 416, 557, 1220, 1254, 1969, 1978, 2113, 2131, 2194, 2466, 2584, 3208, 3297, 3371, 3638, 3660, 3726, 3891, 4946, 4974, 5042, 5067, 5093], 'Aβ42,': [116, 268, 323, 1140, 3137, 3861, 5068], 'their': [118, 270, 4263], 'respective': [119, 271, 2882, 2942, 3523, 4264], 'inhibitors': [121, 273, 1518, 3124, 3141, 3146, 3166], 'suppressed': [122, 274, 1977], 'More': [126, 278, 750], 'importantly,': [127, 279, 751], 'recombinant-activated': [128, 280], 'JNK-1': [131, 283, 3361, 3377, 3395, 3431, 3443, 3466, 3656], 'could': [132, 284, 3883, 4259, 4284, 4363, 4671], 'differentially': [133, 285, 3670], 'phosphorylate': [134, 286, 2847, 2989, 3671], 'vitro.': [138, 290, 2850], 'Thus,': [139, 291, 1333, 1669, 3681, 4068, 4790], 'may': [142, 294, 537, 634, 783, 848, 1134, 2353, 3301, 3746, 3799, 3825, 3839, 3874, 3996, 4023, 4075, 4112, 4171, 4205, 4462, 4513, 4642, 4884, 4922, 4952, 5138], 'mediate': [143, 295], 'via': [148, 300, 759, 4523, 5140], 'JNK-1.': [151, 303], 'Neurofibrillary': [304], 'tangles': [305, 470, 535, 614], 'composed': [306, 617], 'microtubule-associated': [309], 'protein,': [310], 'tau,': [311, 1560], 'amyloid': [313, 426, 531, 1071, 4861], 'plaques': [314, 1072, 4862], '(Aβ42)': [318], '1The': [319], 'abbreviations': [320], 'used': [321, 1337, 2442], 'are:': [322], 'β-amyloid42;': [324], 'AD,': [325, 4028], 'disease;': [327], 'α7nAChR,': [328, 1141, 4473, 4928], 'receptors;': [332], 'ERK,': [333], 'extracellular': [334, 2836, 3870, 4649], 'signal-regulated': [335, 341], 'kinase;': [336, 343], 'MEK,': [337], 'kinase/extracellular': [340], 'Ach,': [344], 'acetylcholine;': [345], 'JNK,': [346], 'kinase.': [349], 'are': [350, 615, 936, 1005, 1068, 1341, 1570, 2155, 2168, 2181, 3051, 3446, 3534, 3657, 4933, 5004, 5053], 'two': [351, 2208, 2434, 2542, 2635, 3272, 5047], 'cardinal': [352], 'hallmarks': [354], '(AD)': [358], 'brains': [359, 387, 1085, 1579, 3824, 4062], '(1Smith': [360], 'C.': [361, 452, 511, 3765, 4324, 4628, 4758], 'Anderton': [362, 835, 2698, 2730, 2769], 'B.H.': [363, 836, 2699, 2731, 2770], 'Neuropathol.': [364], 'Appl.': [365], 'Neurobiol.': [366, 1325, 1890, 3236, 3600], '1994;': [367], '20:': [368], '322-338Crossref': [369], 'PubMed': [370, 407, 463, 485, 522, 546, 607, 685, 704, 732, 779, 822, 842, 873, 891, 917, 958, 984, 1037, 1061, 1109, 1128, 1375, 1462, 1597, 1632, 1664, 1732, 1880, 2028, 2383, 2663, 2685, 2705, 2737, 2758, 2775, 2800, 2828, 3018, 3044, 3334, 3590, 3620, 3786, 3928, 3945, 3985, 4314, 4332, 4410, 4451, 4558, 4577, 4605, 4636, 4665, 4702, 4742, 4767, 4815, 4842, 4877, 4984, 5119], 'Scopus': [371, 408, 464, 486, 523, 547, 608, 705, 733, 823, 843, 874, 918, 985, 1038, 1110, 1129, 1329, 1376, 1463, 1598, 1633, 1665, 1733, 1881, 1894, 2029, 2384, 2664, 2686, 2706, 2759, 2776, 2801, 2829, 3045, 3240, 3335, 3591, 3604, 3621, 3787, 3929, 3946, 3986, 4315, 4333, 4411, 4452, 4578, 4606, 4637, 4666, 4703, 4743, 4768, 4816, 4878, 4985, 5120], '(29)': [372], 'Google': [373, 410, 466, 488, 525, 549, 610, 686, 707, 735, 748, 780, 825, 845, 876, 892, 920, 959, 987, 1000, 1040, 1062, 1112, 1131, 1331, 1378, 1465, 1600, 1635, 1667, 1735, 1883, 1896, 2031, 2386, 2666, 2688, 2708, 2738, 2761, 2778, 2803, 2831, 3019, 3047, 3242, 3337, 3593, 3606, 3623, 3789, 3931, 3948, 3988, 4317, 4335, 4413, 4430, 4454, 4559, 4580, 4608, 4621, 4639, 4668, 4705, 4745, 4770, 4818, 4843, 4880, 4987, 5122], 'Scholar).': [374, 526, 550, 611, 749, 781, 921, 1332, 1466, 1601, 1668, 3338, 4455, 4669, 4771, 5123], 'Recently,': [375], 'it': [376, 639, 3244, 4457], 'was': [377, 1251, 1395, 1478, 1771, 1846, 1966, 2117, 2129, 2939, 2947, 3096], 'shown': [378, 798, 1606, 2156, 2200, 3200, 3549, 4532], 'direct': [380], 'injection': [381], 'fibrils': [384, 3863, 3882, 3991, 4033, 4059, 4073, 5152], 'into': [385, 4651], 'P301L': [389], 'mutant': [390, 419, 425], 'transgenic': [392, 421, 429], 'mice': [393, 422, 430, 5155], '(2Gotz': [394, 472], 'J.': [395, 400, 454, 473, 478, 513, 680, 721, 743, 774, 886, 953, 973, 995, 1026, 1056, 1098, 1324, 1451, 1583, 1586, 1617, 1721, 1869, 1889, 2017, 2372, 2653, 2681, 2700, 2732, 2753, 2768, 2817, 3013, 3235, 3579, 3599, 3767, 3775, 3953, 3955, 3975, 4303, 4327, 4399, 4425, 4440, 4553, 4594, 4616, 4631, 4710, 4712, 4732, 4761, 4837, 5108], 'Chen': [396, 474], 'F.': [397, 475, 883, 3010, 3961, 4718], 'van': [398, 476], 'Dorpe': [399, 477], 'Nitsch': [401, 479], 'R.M.': [402, 480], 'Science.': [403, 459, 481, 518, 542, 4980], '2001;': [404, 460, 482, 519, 543, 682, 701, 745, 776, 955, 997, 1058, 1125, 2797, 3925, 4427, 4555, 4574, 4618, 4699, 4839, 4874], '293:': [405, 461, 483, 520, 544], '1491-1495Crossref': [406, 484], '(1288)': [409, 487], 'Scholar)': [411, 467, 846, 1379, 1736, 1897, 2032, 2739, 2779, 3790, 4336, 4414, 4746, 4844, 4988], 'progenies': [414], 'obtained': [415, 1282, 1772, 2633], 'crossing': [417], 'JNPL3': [418], 'to': [423, 569, 642, 799, 938, 1011, 1165, 1234, 1304, 1313, 1359, 1419, 1544, 1607, 1612, 1647, 1676, 1786, 1822, 1829, 2034, 2119, 2443, 2485, 2619, 2846, 2898, 2950, 2972, 2988, 3055, 3099, 3136, 3317, 3365, 3382, 3428, 3505, 3710, 3793, 3802, 3830, 3859, 3877, 3909, 4037, 4114, 4140, 4152, 4161, 4164, 4178, 4262, 4348, 4470, 4479, 4482, 4533, 4644, 4678, 4786, 4793, 4891, 4918, 4935, 5145, 5160], 'Tg2576': [424], 'precursor': [427], '(3Lewis': [431], 'J': [432, 491, 837], 'Dickson': [433, 492], 'D.W.': [434, 493], 'Lin': [435, 494], 'W.L.': [436, 495], 'Chisholm': [437, 496], 'L.': [438, 448, 497, 507], 'Corral': [439, 498], 'A.': [440, 499, 596, 603, 700, 814, 903, 1055, 1615, 2697, 2796, 3030, 4573, 4760, 4836], 'Jones': [441, 500], 'G.': [442, 501, 2717, 3761], 'Yen': [443, 502], 'S.H.': [444, 503], 'Sahara': [445, 504], 'N.': [446, 505], 'Skipper': [447, 506], 'Yager': [449, 508], 'D.': [450, 509, 673, 693, 767, 901, 946, 2789, 3028, 4437, 4546, 4566], 'Eckman': [451, 510], 'Hardy': [453, 512], 'Hutton': [455, 514], 'M.': [456, 515, 588, 671, 765, 806, 808, 944, 1619, 2675, 2677, 3959, 4544, 4716], 'McGowan': [457, 516], 'E.': [458, 517, 1051, 2657, 3757, 4832], '1487-1491Crossref': [462, 521], '(1282)': [465, 524], 'accelerated': [468], 'formation': [471, 1013, 3887], 'Scholar,': [489, 687, 708, 736, 826, 877, 893, 960, 988, 1041, 1113, 1884, 2667, 2689, 2709, 2762, 2804, 3020, 3594, 3607, 3932, 3949, 4318, 4431, 4560, 4581, 4609, 4622, 4706], '3Lewis': [490], 'This': [527, 782, 1961, 2978, 3630, 4670], 'finding': [528], 'suggests': [529], 'deposits': [532], 'development': [536, 4858], 'be': [538, 800, 849, 1135, 1314, 1787, 2486, 3366, 3635, 3729, 3734, 4260, 4285, 4349, 4499, 4672, 4885, 4953, 4990], 'related': [539], '(4Lee': [540], 'V.M.-Y.': [541], '1446-1447Crossref': [545], '(42)': [548], 'Aβ-tau': [552], 'relationship': [553, 1138], 'further': [555, 2265, 3186, 3651, 4235, 4774], 'supported': [556], 'fact': [559, 4360, 4898], 'primary': [561, 630, 3053, 5079], 'neurons': [563, 631, 1077, 3913, 3995, 4687, 4925, 5083], 'tau-deficient': [565], 'mice,': [566, 575], 'contrast': [568], 'wild': [573], 'type': [574], 'did': [576, 2228, 2249], 'not': [577, 1907, 1967, 2229, 2250, 2409, 2415, 2932, 2976, 3089, 3182, 3363, 3386, 5129], 'any': [579, 4142], 'signs': [580], 'degeneration': [582], 'upon': [583, 2040], 'fibrillar': [584], 'Aβ': [585, 1292, 1308, 1335, 2343, 2350, 3727, 3862, 3881, 3890, 3905, 3990, 4016, 4032, 4045, 4058, 4070, 4072, 4154, 4281, 5038, 5135, 5151], 'treatments': [586, 2458], '(5Rapoport': [587], 'Dawson': [589], 'H.N.': [590], 'Binder': [591], 'L.I.': [592], 'Vitek': [593], 'M.P.': [594], 'Ferreira': [595], 'Proc.': [597, 694, 2790, 4567], 'Natl.': [598, 695, 2791, 4568], 'Acad.': [599, 696, 2792, 4569], 'Sci.': [600, 697, 2793, 4570], 'U.': [601, 698, 2794, 4571], 'S.': [602, 699, 812, 879, 2721, 2764, 2795, 3006, 4572, 4802], '2002;': [604, 2734, 3942, 4443, 4662, 4764, 4981], '99:': [605], '6364-6369Crossref': [606], '(686)': [609], 'largely': [616], 'paired': [619, 1573], 'helical': [620, 1574], 'filaments': [621, 1575], 'contained': [623, 3555], 'treatment': [628, 2042, 3412], 'result': [635, 3813, 3867], 'pertinent': [641], 'understand': [643], 'molecular': [645, 1318, 4271, 4887], 'entities': [647], 'Several': [653, 2646], 'studies': [654, 3340, 4418, 5087], 'have': [655, 784, 2211, 2843, 2985, 2995, 3199, 3548, 3840, 4530, 5026], 'demonstrated': [656, 2845, 2987, 3908, 5027], 'interaction': [658, 930, 3300, 4013, 4208, 4475, 4779, 4902], 'between': [659, 4251], '(6Dineley': [668, 762, 941, 4541], 'K.T.': [669, 763, 942, 4433, 4542], 'Westerman': [670, 764, 943, 4543], 'Bui': [672, 766, 945, 4436, 4545], 'Bell': [674, 768, 947, 4434, 4547], 'K.': [675, 769, 948, 1625, 2649, 4548, 4804], 'Ashe': [676, 770, 949, 4549], 'K.H.': [677, 771, 950, 4550], 'Sweatt': [678, 772, 866, 951, 4438, 4551], 'J.D.': [679, 773, 952, 3967, 4439, 4552, 4724], 'Neurosci.': [681, 744, 775, 869, 887, 954, 996, 1057, 2733, 3014, 4426, 4554, 4617, 4806, 4838], '21:': [683, 746, 777, 956, 998, 1059, 4428, 4556, 4619, 4808, 4840], '4125-4133Crossref': [684, 778, 957, 4557], '7Liu': [688, 4561], 'Q.-S.': [689, 2785, 4562], 'Kawai': [690, 2786, 4563], 'H.': [691, 1650, 2655, 2787, 3320, 3969, 4564, 4726], 'Berg': [692, 2788, 4565], '98:': [702, 2798, 4575], '4734-4739Crossref': [703, 2799, 4576], '(296)': [706, 2802, 3788, 4579], '8Wang': [709, 961, 2805, 4582], 'H.-Y.': [710, 962, 1015, 1087, 1119, 1323, 1440, 1710, 1858, 1888, 2006, 2361, 2806, 3234, 3568, 3598, 3919, 3940, 4292, 4388, 4583, 4660, 4693, 4868, 5097], 'Lee': [711, 963, 1016, 1088, 1122, 1369, 1441, 1711, 1859, 2007, 2362, 2676, 2807, 3569, 3614, 3760, 3922, 4293, 4321, 4389, 4584, 4625, 4696, 4871, 5098], 'D.H.S.': [712, 964, 1017, 1089, 1123, 1321, 1370, 1442, 1712, 1860, 1886, 2008, 2363, 2808, 3232, 3570, 3596, 3615, 3923, 4294, 4322, 4390, 4585, 4626, 4697, 4872, 5099], "D'Andrea": [713, 965, 1018, 1090, 1443, 1713, 1861, 2009, 2364, 2809, 3571, 3935, 4295, 4391, 4586, 4655, 5100], 'M.R.': [714, 966, 1019, 1091, 1115, 1444, 1714, 1862, 2010, 2365, 2810, 3572, 3915, 3936, 4296, 4392, 4587, 4656, 4689, 4864, 5101], 'Peterson': [715, 967, 1020, 1092, 1120, 1445, 1715, 1863, 2011, 2366, 2811, 3573, 3920, 4297, 4393, 4588, 4694, 4869, 5102], 'P.A.': [716, 968, 1021, 1093, 1121, 1446, 1716, 1864, 2012, 2367, 2812, 3574, 3921, 4298, 4394, 4589, 4695, 4870, 5103], 'Shank': [717, 969, 1022, 1094, 1367, 1447, 1717, 1865, 2013, 2368, 2813, 3575, 3612, 4299, 4325, 4395, 4590, 4629, 5104], 'R.P.': [718, 970, 1023, 1095, 1368, 1448, 1718, 1866, 2014, 2369, 2814, 3576, 3613, 4300, 4326, 4396, 4591, 4630, 5105], 'Reitz': [719, 971, 1024, 1096, 1449, 1719, 1867, 2015, 2370, 2815, 3577, 4301, 4397, 4592, 5106], 'A.B.': [720, 972, 1025, 1097, 1450, 1720, 1868, 2016, 2371, 2816, 3578, 4302, 4398, 4593, 5107], 'Biol.': [722, 974, 1027, 1099, 1452, 1587, 1722, 1870, 2018, 2373, 2818, 3580, 3776, 4304, 4400, 4441, 4595, 4763, 5109], 'Chem.': [723, 975, 1028, 1100, 1453, 1588, 1723, 1871, 2019, 2374, 2819, 3581, 3777, 4305, 4401, 4442, 4596, 5110], '2000;': [724, 839, 976, 1029, 1101, 1454, 1589, 1724, 1872, 2020, 2375, 2820, 3582, 3977, 4306, 4329, 4402, 4597, 4633, 4734, 5111], '275:': [725, 977, 1030, 1102, 1455, 1590, 1725, 1873, 2021, 2376, 2821, 3583, 4307, 4403, 4598, 5112], '5626-5632Abstract': [726, 978, 1031, 1103, 1456, 1726, 1874, 2022, 2377, 2822, 3584, 4308, 4404, 4599, 5113], 'Full': [727, 729, 912, 914, 979, 981, 1032, 1034, 1104, 1106, 1457, 1459, 1592, 1594, 1727, 1729, 1875, 1877, 2023, 2025, 2378, 2380, 2823, 2825, 3039, 3041, 3585, 3587, 3781, 3783, 3980, 3982, 4309, 4311, 4405, 4407, 4446, 4448, 4600, 4602, 4737, 4739, 4810, 4812, 5114, 5116], 'Text': [728, 730, 913, 915, 980, 982, 1033, 1035, 1105, 1107, 1458, 1460, 1593, 1595, 1728, 1730, 1876, 1878, 2024, 2026, 2379, 2381, 2824, 2826, 3040, 3042, 3586, 3588, 3782, 3784, 3981, 3983, 4310, 4312, 4406, 4408, 4447, 4449, 4601, 4603, 4738, 4740, 4811, 4813, 5115, 5117], 'PDF': [731, 916, 983, 1036, 1108, 1461, 1596, 1731, 1879, 2027, 2382, 2827, 3043, 3589, 3785, 3984, 4313, 4409, 4450, 4604, 4741, 4814, 5118], '(734)': [734, 986, 1039, 1111, 1464, 1734, 1882, 2030, 2385, 2830, 3592, 4316, 4412, 4607, 5121], '9Pettit': [737, 989, 4610], 'D.L.': [738, 990, 4420, 4611], 'Shao': [739, 991, 4421, 4612], 'Z.': [740, 992, 4422, 4613], 'Yakel': [741, 993, 4423, 4614], 'J.L.': [742, 994, 4424, 4615], '1-5Crossref': [747, 999, 4429, 4620], 'activates': [753, 3245, 4780], 'major': [785], 'implications': [786], 'for': [787, 1199, 1240, 1414, 1529, 1781, 1815, 1825, 1937, 1957, 2072, 2089, 2358, 2552, 2594, 2604, 3167, 3267, 3303, 3311, 3380, 3426, 3451, 3514, 3690, 3736, 3748, 4078, 4282, 4344, 4955, 5173], 'pathology': [790], 'because': [791, 2983, 3280, 3904, 4040, 4132, 5001, 5069], 'has': [796, 1604, 3906], 'been': [797, 1605, 2212, 2844, 2986, 2996, 3907, 4531], '(10Goedert': [805], 'Hasegawa': [807], 'Jakes': [809, 2672], 'R.': [810, 1043, 1585, 2673, 2711, 3763, 4756, 4824], 'Lawler': [811], 'Cuenda': [813], 'Cohen': [815], 'P.': [816, 1045, 2679, 3971, 4728, 4826], 'FEBS': [817, 2658], 'Lett.': [818, 2659], '1997;': [819, 2702], '409:': [820], '57-62Crossref': [821], '(261)': [824, 1634], '11Reynolds': [827], 'C.H.': [828, 2691, 2719], 'Betts': [829], 'J.C.': [830, 861], 'Blackstock': [831], 'W.P.': [832], 'Nebreda': [833], 'A.R.': [834], 'Neurochem.': [838, 2701, 2754, 4328, 4632], '74:': [840], '1587-1595Crossref': [841], '(315)': [844], 'long': [852, 2999], 'term': [853, 3000], 'potentiation': [854, 3001], 'memory': [856, 939, 1012, 3003, 4798, 4850, 4919, 4957], 'processes': [857, 940, 3004, 4906], '(12Atkins': [858], 'C.M.': [859], 'Selcher': [860], 'Petraitis': [862], 'J.J.': [863], 'Trzaskos': [864], 'J.M.': [865, 1652, 2669, 3322], 'J.D': [867], 'Nat.': [868], '1998;': [870, 1629, 1661, 3331, 4807], '1:': [871], '602-609Crossref': [872], '(952)': [875], '13Blum': [878], 'Moore': [880, 3007], 'A.N.': [881, 3008], 'Adams': [882, 3009], 'Dash': [884, 3011], 'P.K.': [885, 3012], '1999;': [888, 909, 1372, 3015, 3036, 3617, 3778], '19:': [889, 3016], '3535-3544Crossref': [890, 3017], '14Winder': [894, 3021], 'D.G.': [895, 3022], 'Martin': [896, 3023], 'K.C.': [897, 3024], 'Muzzio': [898, 3025], 'I.A.': [899, 3026], 'Rohrer': [900, 3027], 'Chruscinski': [902, 3029], 'Kobilka': [904, 3031], 'B.': [905, 3032, 3957, 4714], 'Kandel': [906, 3033], 'E.R.': [907, 3034], 'Neuron.': [908, 3035], '24:': [910, 3037], '715-726Abstract': [911, 3038], '(289)': [919, 3046], 'Together': [922], 'facts': [925], '(a)': [927, 2608], 'Aβ42-α7nAChR': [929, 1155, 3299, 4381, 4778, 4901], 'modulates': [931, 4903], 'neuronal': [932, 2993, 4241, 4749], 'physiological': [933, 4795], 'functions': [934, 4851], 'relevant': [937, 1010, 4036, 4999], 'Scholar),': [1001, 1063, 1132, 1636, 2387, 2832, 3048, 3243, 3624, 3989, 4640, 4819, 4881], '(b)': [1002], 'distributed': [1006], 'brain': [1008, 1179, 1921, 2925, 3565, 3798, 4846], 'regions': [1009, 4847], '(8Wang': [1014, 1086, 1439, 1709, 1857, 2005, 2360, 3567, 4291, 4387, 5096], '15Fabian-Fine': [1042], 'Skehel': [1044, 4825], 'Errington': [1046, 4827], 'M.L.': [1047, 4828], 'Davies': [1048, 4323, 4627, 4829], 'H.A.': [1049, 4830], 'Sher': [1050, 4831], 'Stewart': [1052, 4833], 'M.G.': [1053, 4834], 'Fine': [1054, 4835], '7993-8003Crossref': [1060, 4841], '(c)': [1065], 'co-localized': [1069], 'containing': [1078, 1400, 1506, 2067, 2531, 2589], 'abundant': [1079, 4116], 'intracellular': [1080, 4680], "16D'Andrea": [1114], 'Nagele': [1116, 3916, 4690, 4865], 'R.G.': [1117, 3917, 3934, 4654, 4691, 4866], 'Wang': [1118, 1322, 1887, 3233, 3597, 3918, 3939, 4659, 4692, 4867], 'Histopathol.': [1124, 3924, 4698, 4873], '38:': [1126, 3926, 4700, 4875], '120-134Crossref': [1127, 3927, 4701, 4876], '(318)': [1130, 3930, 4704, 4879], 'there': [1133], 'functional': [1137], 'linking': [1139, 4889], 'tau.': [1143, 3680], 'In': [1144, 1467, 1916, 2337, 3057, 4894, 5016], 'this': [1145, 1339, 3459, 3682, 3749, 4065, 4240, 4376, 4474, 4521, 4921, 5017], 'study,': [1146], 'downstream': [1150], 'events': [1152, 1162, 3049, 4026, 4184], 'interaction.': [1156], 'tracked': [1158], 'response': [1164, 3709], 'stimulation': [1167, 3488, 3829], 'using': [1168, 1427, 1685, 1848, 2873, 3062, 3525, 5150], 'experimental': [1169, 2045, 3391, 3552, 4136, 4203], 'contain': [1172, 1998, 2244, 2354, 4463], 'Our': [1181, 4501, 5051], 'results': [1182, 2509, 3185, 4502, 5052], 'suggest': [1183, 2510, 3441], 'key': [1188, 3688], 'mediator': [1189, 3689, 4888], 'Antisense': [1195], 'Oligonucleotides—Orthothioate': [1196], 'antisense': [1197, 1230, 1269, 2545, 2558, 3479], '(AS1,': [1202], '5′-CCACATAGCTCCCGCCAAGT-3′,': [1203], 'AS2,': [1205, 2440, 2549, 3422, 3484], '5′-GAAGATGTCCATGTCAGGGTTCAAG-3′),': [1206], 'neurokinin': [1208, 2567], 'receptor': [1209, 2329, 2568, 2837], '1': [1210, 1401, 2569, 2839], '(5′-CCACTAACACCTCGGAACCCAATCA-3′),': [1211], 'scramble': [1214, 2572], 'control': [1215, 1385], 'oligonucleotide': [1216, 1231, 1270, 2559], '(5′-ATACACCTGCACACCGTCCG-3′)': [1217], 'prepared': [1219, 1297, 1357], 'BioSource': [1221], 'International': [1222], 'Inc.': [1223], '(Camarillo,': [1224], 'CA).': [1225, 1288], '10–30': [1226], 'μm': [1227, 1508, 2540], 'each': [1229, 1266, 1290, 2190], 'added': [1233], 'cultured': [1239, 2426, 4165], '4': [1241, 1818, 2073, 2553, 2595, 2973, 3383], 'days': [1242], 'one': [1244, 4673], 'medium': [1245, 2066, 2530, 2588], 'change': [1246], 'before': [1247, 1417, 1827, 2297, 3134, 3487], 'analyses.': [1248], 'Cellular': [1249], 'toxicity': [1250], 'closely': [1252], 'monitored': [1253], 'trypan': [1255], 'blue': [1256, 1411], 'exclusion,': [1257], 'consistently': [1259, 2896], '>85%': [1260], 'survived': [1264], 'treatments.': [1271], 'Peptides': [1272], 'Peptide': [1274], 'Preparations—Aβ': [1275], 'peptides,': [1276], 'galanin,': [1277], 'neuropeptide': [1279], 'Y': [1280], 'from': [1283, 1577, 1747, 1900, 2162, 2207, 4488], 'Palomar': [1284], 'Research': [1285], 'Inc': [1286], '(Encinitas,': [1287], 'For': [1289, 4276], 'experiment,': [1291], 'peptide': [1293, 2344, 4377], 'solutions': [1294, 1309], 'freshly': [1296], '50': [1299, 1501, 2107], 'mm': [1300, 1402, 1502, 1511, 1514], 'HEPES,': [1301, 1503], 'pH': [1302, 1504], '9.0,': [1303], 'minimize': [1305], 'autoaggregation.': [1306], 'These': [1307, 3184, 3880], 'thoroughly': [1311], 'characterized': [1312], 'devoid': [1315], 'high': [1317, 2492, 2525], 'aggregates': [1319], '(17Lee': [1320, 3231], '2003;': [1326, 1891, 3237, 3601], '25:': [1327, 1892, 3238, 3602], '25-30Crossref': [1328, 1893, 3239, 3603], '(64)': [1330, 1895, 3241, 3605], 'peptides': [1336], 'study': [1340, 3683, 5127], 'mainly': [1342], 'present': [1343, 4120, 5126], 'monomeric,': [1345], 'dimeric,': [1346], 'small': [1348], 'oligomeric': [1349, 4976], 'forms.': [1350], 'p-Tau': [1351], 'Blot': [1353], 'Analyses—Hippocampal': [1354], 'synaptosomes': [1355, 1853, 1996, 2242, 2926, 3566], 'according': [1358], 'those': [1360, 5086], 'described': [1361, 1437, 1552, 2626, 3700], 'earlier': [1362, 4963], '(18Wang': [1363], 'H.-Y': [1364, 3609, 4320, 4624], 'Wild': [1365, 3610], 'K.D.': [1366, 3611], 'Neuropeptides.': [1371, 3616], '33:': [1373, 3618], '197-205Crossref': [1374, 3619], '(51)': [1377, 3622], 'treated': [1381, 1700, 2080, 2289, 2610, 2870, 3117, 3472], 'peptides.': [1386], 'At': [1387, 1533, 2095, 2574], 'time': [1388, 1531, 2916], 'intervals,': [1389], 'an': [1390, 1836, 2557, 3219, 3252, 3752], 'aliquot': [1391], 'sample': [1394, 2191], 'mixed': [1396], 'loading': [1398], 'buffer': [1399], 'β-mercaptoethanol,': [1403], '0.1%': [1404, 2068, 2590], 'SDS,': [1405], '10%': [1406, 2532], 'glycerol,': [1407], '0.01%': [1409], 'bromphenol': [1410], 'boiled': [1413], '5': [1415, 2196], 'min': [1416, 1794, 1933, 2091, 2962, 3370], 'subjecting': [1418], 'denaturing': [1420, 1545, 2120], 'PAGE': [1421, 1547, 2123, 2621], 'appropriate': [1424], 'specific': [1428, 2252, 2854, 2877, 3122, 3344], 'p-tau': [1429, 1958, 2039, 2153, 2475, 3276, 3795, 3804, 3837, 3878, 3886, 4083, 4119], 'antibodies': [1430, 1691, 2135, 2878], '(Innogenetics,': [1431], 'Temse,': [1432], 'Belgium,': [1433], 'BioSource)': [1435], 'as': [1436, 1551, 2111, 2199, 2402, 2464, 2625, 3218, 3251, 3491, 3686, 3811, 3865, 3888, 4109, 4229, 4267, 4269, 4908, 4930, 5091], 'previously': [1438], 'Vitro': [1468], 'Tau': [1469], 'Kinase': [1470], 'Assay—Recombinant': [1471], '(1': [1473, 2084], 'μg,': [1474], 'PanVera,': [1475], 'Madison,': [1476], 'WI)': [1477], 'incubated': [1479, 3067], '10': [1481, 1507, 2537, 2961, 3369], 'units': [1482], 'recombinant': [1484, 1491, 3065, 3069], 'ERK1': [1486, 2936, 3080], '0.1': [1488], 'unit': [1489], 'ERK2': [1493, 2938, 3082], '(Upstate': [1494], 'Biotech.': [1495], 'Inc,': [1496], 'Lake': [1497], 'Placid,': [1498], 'NY)': [1499], '7.4,': [1505], 'ATP,': [1509], '2': [1510, 1513, 2841], 'Ca2+,': [1512], 'Mg2+,': [1515], 'protease': [1517], '(Roche': [1519], 'Applied': [1520], 'Science)': [1521], 'final': [1524], 'volume': [1525], '100': [1527, 1774, 2612], 'μl': [1528], 'various': [1530, 2082], 'intervals.': [1532], 'end': [1535, 2097, 2576], 'incubation,': [1538, 2100, 2579], 'aliquots': [1539], 'removed': [1541], 'subjected': [1543, 2118, 2618, 3504], 'gradient': [1546, 2122], 'above.': [1553], 'Among': [1554], 'many': [1556], 'at': [1561, 1816, 2075, 2092, 2163, 2491, 3157], 'least': [1562, 1817, 2164], 'phosphorylated': [1571, 3084], 'isolated': [1576], 'AD': [1578, 3742, 3797, 3823, 4038, 4053, 4061, 4085, 4122, 4537, 4686, 4752, 4938, 4995], '(19Maas': [1580], 'T.': [1581, 2713], 'Eidenmuller': [1582], 'Brandt': [1584, 3762], '15733-15740Abstract': [1591], '(190)': [1599], 'Specifically,': [1602], 'Thr-231': [1603, 1799, 3090, 3305, 3398], 'directly': [1608, 3884], 'affect': [1609], 'binding': [1611, 1646, 2356, 3316, 4265], 'microtubules': [1613, 1648, 3318], '(20Sengupta': [1614], 'Kabat': [1616], 'Novak': [1618], 'Wu': [1620], 'Q.': [1621], 'Grundke-Iqbal': [1622], 'I.': [1623, 2729], 'Iqbal': [1624], 'Arch.': [1626], 'Biochem.': [1627, 2680], 'Biophys.': [1628], '357:': [1630], '299-309Crossref': [1631], 'whereas': [1637, 1768, 2314, 3165], 'Ser-202': [1638, 1783, 3085, 3406], 'Thr-181': [1640, 1797, 3087, 3408], 'modulate': [1641], 'kinetics': [1643, 1780, 1911, 2215, 2922, 2944, 3095], '(21Xie': [1649, 3319], 'Litersky': [1651, 3321], 'Hartigan': [1653, 3323], 'J.A.': [1654, 3324], 'Jope': [1655, 3325], 'R.S.': [1656, 3326], 'Johnson': [1657, 2670, 3327], 'G.V.': [1658, 2671, 3328], 'Brain': [1659, 3329], 'Res.': [1660, 3330], '798:': [1662, 3332], '173-183Crossref': [1663, 3333], '(61)': [1666, 3336], 'verified': [1671, 2465], 'ability': [1673, 3425], 'induce': [1677, 2230, 3885, 4141, 4162, 4483], 'these': [1681, 3438, 3668, 3994, 4088, 4170], 'different': [1687, 2133, 2166, 2435, 5141], 'anti-phosphorylated': [1688], '(p-tau)': [1690], 'recognized': [1693, 2137, 2880], 'p-Ser-202,': [1694, 1926, 3354], 'p-Thr-181,': [1695, 1927], 'p-Thr-231,': [1697, 3353], 'respectively.': [1698], 'expressed': [1707, 5089], 'analyzed': [1740, 2130, 2602, 3513], 'proteins': [1743, 4195, 4784], 'immunoprecipitated': [1746, 2305, 3497], 'solubilized': [1749], 'cell': [1750, 3494, 4950, 5071], 'lysates.': [1751], 'blot': [1753, 2128], 'dose-dependently': [1758, 2051], 'all': [1762, 5088], 'tested,': [1767, 2346], 'maximal': [1769, 3312], 'nm': [1775, 2613], '(Fig.': [1777, 1807, 1840, 1973, 1983, 2047, 2335, 2392, 2404, 2469, 2480, 3108, 3373, 3409, 3434], '1a).': [1778], 'appeared': [1785, 2484], 'fastest': [1789], 'saturated': [1791, 1803, 1930], '15': [1793, 1932], 'while': [1795], 'phosphorylations': [1800], 'slowly': [1802], 'within': [1804, 1931, 2914, 2960, 3368, 4468], '1–2': [1805], 'h': [1806, 1819, 1824, 1939, 1943, 2074, 2596, 2974, 3384], '1b).': [1808, 1841], 'p-Thr-181': [1811], 'p-Thr-231': [1813, 1929, 3282], 'remained': [1814, 2969, 3378], 'up': [1821, 2971, 3381], '16': [1823], 'p-Ser-202': [1826], 'returning': [1828], 'ground': [1830], 'state,': [1831], 'implying': [1832], 'presence': [1834, 1948, 2429, 3074, 3516, 3808, 4056], 'endogenous': [1837, 3846], 'dephosphorylation': [1838, 1955, 3754, 3847, 4000], 'system': [1839, 1956, 3061, 3755, 4204], 'Similar': [1842, 2205, 2630], 'detected': [1847], 'frontal': [1849], 'cortical': [1850, 5080], '17Lee': [1885, 3595], 'prepared,': [1898], 'respectively,': [1899, 1945], 'rat': [1901, 1918, 1994], 'neurologically': [1903], 'normal': [1904, 3707], '(data': [1906, 2414, 2931, 2975, 3181, 3385], 'shown),': [1908, 2416, 2933], 'although': [1909], 'observed': [1912, 3101, 3740, 4684, 4961], 'slightly': [1914], 'different.': [1915], 'both': [1917, 2955, 3079, 3430, 4383, 5007], 'synaptosomal': [1922], 'preparations,': [1923], 'but': [1934, 1975, 2408, 3088, 3362, 3399], 'sustained': [1935, 3828], 'only': [1936, 2347, 2398, 3138, 3265], '∼1': [1938], '(rat)': [1940], '∼0.5': [1942], '(human),': [1944], 'suggesting': [1946, 3643], 'vigorous': [1951], 'tightly': [1953], 'regulated': [1954], 'vivo.': [1960], 'event': [1965, 3699], 'Aβ40-1': [1970], 'Aβ42-1': [1972], '1c)': [1974], 'effectively': [1976, 2459, 3626], 'antagonist,': [1981, 2293], 'α-bungarotoxin': [1982, 2311], '1,': [1984], 'b).': [1987], 'Furthermore,': [1988, 3110], 'Bowes': [1990, 2238], 'melanoma': [1991, 2239], 'striatum': [1995], 'undetectable': [1999, 2245], 'low': [2001, 4198], 'levels': [2002, 2246, 2463], 'failed': [2033, 2897, 4139], 'generate': [2035, 3831], 'significant': [2036], 'amounts': [2037, 3835], 'under': [2043], 'conditions': [2046], '1d).Fig.': [2048], '1a,': [2049], 'stimulated': [2052, 2417], 'maintained': [2058, 2523], '12-well': [2061], 'culture': [2062, 2064, 2587], 'plate': [2063], 'fetal': [2069, 2533, 2591], 'bovine': [2070], 'serum': [2071, 2535, 2593, 4157, 4199], '37': [2076], '°C': [2077], 'then': [2079, 2598, 2617], 'concentrations': [2083, 2432, 2493, 3159, 3477, 4006, 4042], 'pm–1': [2085], 'μm)': [2086], '20': [2090], '25': [2093], '°C.': [2094], 'lysed': [2103, 2600], 'SDS': [2105], 'μg': [2108], 'determined': [2112], 'reagent': [2115], '(Bio-Rad)': [2116], '8–16%': [2121], 'blotting.': [2126, 3509], 'anti-p-tau': [2134, 3063], 'distinct': [2139], 'tau:': [2143], 'p-Ser-202-tau,': [2144], 'p-Thr-231-tau,': [2145], 'p-Thr-181-tau.': [2147], 'Optical': [2148], 'densitometric': [2149], 'scans': [2150], 'bands': [2154], 'right.': [2159], 'Mean': [2160], 'data': [2161, 2206, 2631, 3439], 'experiments': [2167, 2210], 'presented,': [2169], 'error': [2171], 'bars': [2172], 'indicate': [2173, 3341], 'mean': [2174], '±': [2175], 'S.E.': [2176], 'Molecular': [2177, 3530], 'masses': [2178, 3531], 'kDa': [2180, 3533], 'indicated': [2182], 'left.': [2185], 'Total': [2186], 'content': [2188], 'represented': [2193], '(BioSource)': [2197], 'staining': [2198], 'top': [2203], 'panel.': [2204], 'separate': [2209, 2543, 2636], 'obtained.': [2213], 'b,': [2214], 'α7nAChR-mediated': [2217, 3695], 'cells.': [2224, 2235], 'c,Aβ40–1': [2225], 'Aβ42–1': [2227], 'd,': [2236], 'striatal': [2241], 'exhibit': [2251], 'phosphorylation.View': [2255], 'Large': [2256, 2638, 3539], 'Image': [2257, 2639, 3540], 'Figure': [2258, 2640, 3541], 'ViewerDownload': [2259, 2641, 3542], 'Hi-res': [2260, 2642, 3543], 'image': [2261, 2643, 3544], 'Download': [2262, 2644, 3545], '(PPT)': [2263, 2645, 3546], 'To': [2264, 2851], 'define': [2266], 'involvement': [2268, 3189, 4030], 'tested': [2277], 'pharmacological': [2279, 5023], 'effects': [2280, 4174, 4224], 'several': [2282, 4904], 'nAChR': [2283], 'ligands.': [2284], 'Serum-deprived': [2285], 'methyllycaconitine': [2294, 2309], 'α-bungarotoxin,': [2296], 'addition': [2299, 3858, 4792], 'Aβ42.': [2301], 'Analyses': [2302], 'p-tau,': [2313], 'α1nAChR': [2316], 'antagonist': [2317, 2330, 3223, 3640], '(α-conotoxin': [2318], 'MI),': [2319], 'non-selective': [2321], 'channel': [2323, 3213, 3222, 4243], 'blocker': [2324], '(mecamylamine),': [2325], 'muscarinic': [2328], '(atropine)': [2331], 'had': [2332], 'no': [2333], 'effect': [2334, 3721], '2a).': [2336], 'addition,': [2338], 'among': [2339], 'panel': [2341, 2875, 3120], 'fragments': [2345], 'Aβ12–28,': [2348], 'fragment': [2351, 4378], 'epitope': [2357, 4341, 4467], '2b).': [2393], 'On': [2394], 'other': [2396, 2502, 3293, 3899, 4490, 5134], 'hand,': [2397], 'such': [2401, 4108, 4228, 4907, 4929], 'nicotine': [2403, 4230, 4254, 4290], '2c)': [2405], 'epibatidine': [2407], 'α4β2nAChR': [2411], 'agonist,': [2412], 'cytosine': [2413], 'weak': [2418, 4223], 'transient': [2420, 4221], 'Finally,': [2423, 3411], 'non-toxic': [2431, 3158, 3476], 'oligonucleotides,': [2437, 2546, 3419, 3481], 'AS1': [2438, 2455, 2483, 2547, 3420, 3482], 'test': [2444], 'role': [2446, 3646, 4125, 4238], 'mediating': [2451, 3256], 'AS2': [2457, 2490], 'reduced': [2460, 3352, 4190], 'analysis': [2468, 3060], '3a)': [2470], 'significantly': [2472, 3351, 3801], 'diminished': [2473], '3b).': [2481], 'more': [2487, 4095, 4350, 5158], 'potent': [2488], 'than': [2489, 2503, 4287, 4352], 'suppressing': [2495, 3161], 'pThr-231,': [2496], 'probably': [2497], 'indicating': [2498], 'some': [2499], 'extraneous': [2500], 'activities': [2501, 3270], 'reducing': [2504], 'levels,': [2506], 'cumulative': [2508], 'participate': [2513], 'process.Fig.': [2519], '3SK-N-MC': [2520], 'glucose': [2526], "Dulbecco's": [2527], 'modified': [2528], "Eagle's": [2529], 'calf': [2534, 2592], '30': [2539], 'orthothioate': [2544], 'against': [2550, 2564], 'days.': [2554], 'Controls': [2555], 'include': [2556], 'NK1': [2560], 'directed': [2563], 'oligonucleotide.': [2573], 'incubating': [2585], 'either': [2599, 4092], 'simultaneously': [2603], 'β-actin': [2607], 'Fig.': [2628], '1(b).': [2629], 'experiments.View': [2637], 'kinases': [2647, 2838, 3295, 3449], '(22Baumann': [2648], 'Mandelkow': [2650, 2656], 'E.M.': [2651], 'Biernat': [2652], 'Piwnica-Worms': [2654], '1993;': [2660, 2755], '336:': [2661], '417-424Crossref': [2662], '(425)': [2665], '23Litersky': [2668], 'Goedert': [2674], 'Seubert': [2678], '1996;': [2682, 2772], '316:': [2683], '655-660Crossref': [2684], '(123)': [2687], '24Reynolds': [2690], 'Utton': [2692], 'M.A.': [2693], 'Gibb': [2694, 2716], 'G.M.': [2695], 'Yates': [2696], '69:': [2703], '191-198Crossref': [2704], '(137)': [2707], '25Williamson': [2710], 'Scales': [2712], 'Clark': [2714], 'B.R.': [2715], 'Reynolds': [2718], 'Kellie': [2720], 'Bird': [2722], 'I.N.': [2723], 'Varndell': [2724], 'I.M.': [2725], 'Sheppard': [2726], 'P.W.': [2727], 'Everall': [2728], '22:': [2735], '10-20Crossref': [2736], 'glycogen': [2741, 2886, 2904], 'synthase': [2742, 2887, 2905], '3β': [2744], '(26Yang': [2745], 'S.D.': [2746], 'Song': [2747], 'J.S.': [2748, 2750], 'Yu': [2749], 'Shiah': [2751], 'S.G.': [2752], '61:': [2756], '1742-1747Crossref': [2757], '(75)': [2760], '27Lovestone': [2763], 'Hartley': [2765], 'C.L.': [2766, 3770], 'Pearce': [2767], 'Neuroscience.': [2771, 3941, 4661], '73:': [2773], '1145-1157Crossref': [2774], '(184)': [2777], '(7Liu': [2784], 'particular': [2834, 2981], '(ERKs),': [2842], 'determine': [2852], 'kinase(s)': [2855, 3246], 'Aβ42-α7nAChR-mediated': [2859], 'performed': [2865], 'active': [2883], 'form': [2884, 3520], '3β,': [2889, 2907], 'P38': [2890, 2908], 'kinase,': [2891, 2909], 'ERKs.': [2893], 'While': [2894], 'detect': [2899], 'Aβ42-mediated': [2901, 3631], 'activation': [2902, 2934, 2943, 3462, 5062], 'Cdk5,': [2910], 'phosphatidylinositol': [2912], '3-kinase': [2913], 'period': [2917], 'correlated': [2919], 'noted.': [2940], 'strikingly': [2948], 'fully': [2958, 3703], '(Fig': [2963], '4a),': [2964], 'detectable': [2970, 3379, 4143, 4218], 'shown).': [2977, 3183], 'interest': [2982], 'implicated': [2997], '(13Blum': [3005], 'relevance': [3054], 'AD.': [3056, 4966], 'another': [3058], 'antibodies,': [3064], 'ATP': [3076], 'specifically': [3083, 3359], 'very': [3097], 'cellular': [3104, 3708, 4135, 4186], 'synaptosome': [3106], '4b).': [3109], 'when': [3111], 'separately': [3116], '(H-89,': [3125], 'chelerythrine,': [3126], 'PD169316,': [3127], 'PD98059,': [3128], '5-iodotubercidin,': [3129], 'roscovitine,': [3130], 'U0126,': [3131], 'SP600125)': [3133], 'exposure': [3135], 'ERK': [3140, 3149, 3287], '(5-iodotubercidin': [3142], 'roscovitine)': [3144], 'regulator': [3150], 'MEK': [3151], '(PD98059': [3152], 'U0126)': [3154], 'effective': [3156, 3403], 'A,': [3170], 'C,': [3173], 'P38,': [3174], 'Cdk1,': [3175], 'Cdk2,': [3176], 'Cdk5': [3178], 'ineffective': [3180], 'support': [3187], 'event.': [3197, 3261], 'mediated': [3207], 'pentameric': [3210], 'cation': [3211], 'ion': [3212, 3221, 4242], 'α7nAChR.': [3214, 3468, 3649, 4275], 'behaves': [3217, 3250], 'inhibits': [3225], 'calcium': [3226, 4909], 'mobilization': [3227], 'ACh': [3229, 4911], 'release': [3230], 'agonist': [3254, 4227], 'Nonetheless,': [3262], 'can': [3264, 3634], 'account': [3266, 3302, 3747, 4077], 'studied': [3278, 4519], 'here,': [3279], 'clearly': [3284, 4063], 'independent': [3285], 'activities.': [3288], 'It': [3289], 'likely': [3291, 4096], 'critically': [3309], 'required': [3310], 'inhibition': [3313], 'Pharmacological': [3339], '(JNK)': [3348], 'inhibitor,': [3349], 'SP600125,': [3350], 'p-Thr-181.': [3356], 'Further': [3357, 5148], 'identified': [3360], 'JNK-2': [3364], '5a),': [3374], 'shown)': [3387], 'our': [3389, 4134, 4202], 'system.': [3392], 'efficiently': [3396], 'phosphorylates': [3397], 'relatively': [3401], 'less': [3402], 'phosphorylating': [3405], '5b).': [3410], 'impaired': [3423], 'activate': [3429, 4480], '6).': [3435], 'Taken': [3436], 'together,': [3437], 'strongly': [3440], 'candidate': [3448, 5048], 'responsible': [3450, 3735, 4954], 'Aβ42-induced,': [3453], 'α7nAChR-dependent': [3454, 3664], 'recorded': [3457], 'study.Fig.': [3460], '6Aβ42': [3461], 'involves': [3467], 'without': [3475], 'serum-starved': [3486], 'described.': [3492], 'lysates': [3495], 'anti-ERK1,': [3499], 'anti-ERK2,': [3500], 'anti-JNK-1': [3502], 'electrophoresis': [3506], 'blots': [3511], 'anti-pERK': [3526], 'anti-pJNK': [3528], 'antibodies.': [3529], 'presented': [3535], 'left.View': [3538], 'animal': [3562], '18Wang': [3608], 'appropriately': [3636], 'antisense-α7nAChR,': [3642], 'critical': [3645, 5033], 'illustrate': [3652], 'manner': [3665], 'enzymes': [3669], 'serine': [3675], 'threonine': [3677], 'residues': [3678], 'attributes': [3684], 'here': [3701, 5000], 'reversible,': [3704], 'reflecting': [3705], 'Aβ.': [3711], 'Under': [3712], 'steady': [3713, 4008], 'state': [3714, 4009], 'condition': [3715], 'brain,': [3718], 'net': [3720, 3852], 'might': [3728, 4989], 'minimal': [3730], 'apparently': [3732, 4477], 'cannot': [3733, 4498, 4504], 'hyperphosphorylation': [3739], 'brains.': [3743, 4086, 4123, 4939], 'Three': [3744], 'explanations': [3745], 'discrepancy.': [3750], 'First,': [3751], 'inefficient': [3753], '(28Sontag': [3756], 'Nunbhakdi-Craig': [3758], 'V.': [3759, 3965, 4722], 'Kamibayashi': [3764], 'Kuret': [3766], 'White': [3768], 'III,': [3769], 'Mumby': [3771], 'M.C.': [3772], 'Bloom': [3773], 'G.S.': [3774], '274:': [3779], '25490-25498Abstract': [3780], 'fails': [3792], 'remove': [3794], 'contribute': [3800, 3876, 4113], 'accumulation.': [3805], 'Second,': [3806], 'chronic': [3807, 3869, 4080], 'excess': [3815], 'production': [3817], 'and/or': [3818], 'deficient': [3819], 'clearance': [3821], 'provide': [3826, 5157], 'p-tau.': [3832, 4010, 4219], 'large': [3834], 'formed': [3838, 3864, 3992], 'exceeded': [3841], 'capacity': [3843], 'system,': [3848, 4137], 'thereby': [3849], 'resulting': [3850, 4216], 'hyperphosphorylation.': [3854], 'Third,': [3855], 'soluble': [3860, 3889, 4015, 4044, 4069], 'deposition': [3871], 'also': [3875, 4101, 4503], 'formation.': [3879], 'interacting': [3892], 'same': [3895], 'unknown': [3900], 'surface': [3901], 'receptors.': [3902], 'Alternately,': [3903, 4188], 'accumulate': [3910], 'intracellularly': [3911], "(16D'Andrea": [3914, 4688, 4863], '29Nagele': [3933], 'Anderson': [3937, 4657], 'W.J.': [3938, 4658], '110:': [3943, 4663], '199-211Crossref': [3944, 4664], '(387)': [3947, 4667], '30Gouras': [3950, 4707], 'K.G.': [3951, 4708], 'Tsai': [3952, 4709], 'Naslund': [3954, 4711], 'Vincent': [3956, 4713], 'Edgar': [3958, 4715], 'Checler': [3960, 4717], 'Greenfield': [3962, 4719], 'J.P.': [3963, 4720], 'Haroutunian': [3964, 4721], 'Buxbaum': [3966, 4723], 'Xu': [3968, 4725], 'Greengard': [3970, 4727], 'Relkin': [3972, 4729], 'N.R.': [3973, 4730], 'Am.': [3974, 4731], 'Pathol.': [3976, 4733], '156:': [3978, 4735, 4765], '15-20Abstract': [3979, 4736], '(868)': [3987, 4744], 'inside': [3993], 'impact': [3997], 'pathways,': [4001], 'hence': [4002], 'indirectly': [4003], 'affecting': [4004], '(monomers,': [4017], 'dimers,': [4018], 'oligomers)': [4020], 'reflect': [4024], 'early': [4025], 'equally': [4035], 'pathogenesis': [4039, 4996], 'cerebrospinal': [4048], 'fluid': [4049], 'actually': [4050], 'decline': [4051], 'explains': [4064], 'clinical': [4066], 'observation.': [4067], 'together': [4074], 'adequately': [4076], 'accumulation': [4081, 4681], 'Nevertheless,': [4087], 'potential': [4090], 'mechanisms,': [4091], 'alone': [4093], 'concert': [4098], 'perhaps': [4100], 'conjunction': [4103], 'additional': [4105], 'factors': [4107], 'oxidative': [4110, 4127], 'stress,': [4111], 'persistent': [4118], 'stress': [4128, 4163], 'particularly': [4130], 'noteworthy': [4131], 'unless': [4146], 'prior': [4151], 'treatment.': [4155], 'Since': [4156], 'deprivation': [4158], 'known': [4160], 'involving': [4167], 'free': [4168], 'radicals,': [4169], 'exacerbate': [4172], 'Aβ,': [4176], 'leading': [4177, 4785, 5144], 'subsequent': [4180, 4646, 4948], 'responses.': [4187], 'amount': [4191], 'interfering': [4193], 'Aβ42-binding': [4194], 'environment': [4200], 'allow': [4206], 'efficient': [4207], 'exogenous': [4211], 'albeit': [4222, 4509], 'stimulating': [4232, 4256], 'confirm': [4236], 'differential': [4249], 'efficiencies': [4250], 'attributed': [4261], 'affinities': [4266], 'well': [4268], 'recognition': [4272, 4340], 'epitopes': [4273], 'example,': [4277], 'affinity': [4279], 'higher': [4286], '31Wang': [4319, 4623], '75:': [4330, 4634], '1155-1161Crossref': [4331, 4635], '(404)': [4334, 4638], 'expected': [4347], 'complex': [4351], 'smaller': [4356], 'molecule,': [4357], 'nicotine.': [4358], 'Aβ12–28': [4362, 4461, 4512], 'attenuate': [4364], 'initial': [4373, 4941], 'findings': [4374], 'inhibited': [4379], 'interaction,': [4382], 'immunoprecipitation': [4385], 'experiment': [4386], 'electrophysiology': [4417], '(9Pettit': [4419], '32Dineley': [4432], 'K.A.': [4435], '277:': [4444], '25056-25061Abstract': [4445], '(204)': [4453], 'implies': [4458], 'necessary': [4465], 'contact': [4466], 'interact': [4471, 4534], 'insufficient': [4478], 'Key': [4486], 'contributions': [4487], 'sequence': [4491], 'components': [4492], 'activating': [4496, 5043], 'excluded.': [4500], 'rule': [4505], 'out': [4506], 'possibility,': [4508], 'remote,': [4510], 'negatively': [4514], 'regulate': [4515], 'pathway': [4518], 'report': [4522], 'unidentified': [4524], 'mechanisms.': [4527, 5164], 'lead': [4643], 'internalization': [4647], '(29Nagele': [4653], 'mechanisms': [4676], 'contributing': [4677], 'even': [4748], 'loss': [4750, 4951], '(33Zhang': [4753], 'Y.': [4754], 'McLaughlin': [4755], 'Goodyer': [4757], 'LeBlanc': [4759], 'Cell': [4762], '519-529Crossref': [4766], '(369)': [4769], 'Here': [4772], 'demonstrate': [4775], 'its': [4794, 4820], 'roles': [4796], '(34Auld': [4799], 'D.S.': [4800], 'Kar': [4801], 'Quirion': [4803], 'Trends': [4805], '43-49Abstract': [4809], '(179)': [4817], 'anatomical': [4821], 'distribution': [4822], '(15Fabian-Fine': [4823], 'associated': [4848], 'possible': [4854], 'participation': [4855, 5132], 'dense-core': [4860], 'light': [4895], 'neurochemical': [4905], 'homeostasis,': [4910], 'release,': [4912], 'contributed': [4917], 'physiology,': [4920], 'explain': [4923], 'why': [4924], 'express': [4927], 'pyramidal': [4931], 'neurons,': [4932], 'vulnerable': [4934], 'An': [4940], 'aberrant': [4942], 'physiology': [4944], 'followed': [4945], '"α7nAChR-expressing"': [4949], 'cognition': [4959], 'impairment': [4960], 'stages': [4964], 'A': [4967], 'recent': [4968], 'hypothesis': [4969], 'synaptic': [4971], 'failure': [4972], 'caused': [4973], 'diffusible': [4975], '(35Selkoe': [4978], 'D.J.': [4979], '298:': [4982], '789-791Crossref': [4983], '(3438)': [4986], 'causal': [4992], 'factor': [4993], 'especially': [4998], 'α7nAChRs': [5003], 'located': [5005], 'presynaptic': [5009], 'post-synaptic': [5011], 'cholinergic': [5012], 'cholinoceptive': [5014], 'terminals.': [5015], 'series': [5018], 'biochemical,': [5020], 'cellular,': [5021], 'experiments,': [5024], 'linker': [5034], 'molecule': [5035], 'through': [5036], 'which': [5037], 'JNK-1,': [5046], 'kinases.': [5050], 'agreement': [5055], 'literature': [5058], 'reported': [5060], 'JNK': [5066], 'lines': [5072], 'e.g.': [5073], 'SH-SY5Y,': [5074], 'IMR32,': [5075], 'PC12,': [5077], 'employed': [5084], 'illustrated': [5092], 'Clearly,': [5124], 'does': [5128], 'preclude': [5130], 'operate': [5139], 'mechanisms/pathways,': [5143], 'explorations': [5149], 'α7nAChR-deficient': [5154], 'will': [5156], 'answers': [5159], 'detailed': [5162], 'underlying': [5163], 'thank': [5166], 'Drs.': [5167], 'Sangram': [5168], 'Sisodia': [5169], 'Leona': [5171], 'Ling': [5172], 'helpful': [5174], 'suggestions.': [5175]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1965185022', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 11}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2024-12-31T09:49:56.848565', 'created_date': '2016-06-24'}