Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1965108823', 'doi': 'https://doi.org/10.3354/dao02000', 'title': 'Protection of rainbow trout from infectious hematopoietic necrosis (IHN) by injection of infectious pancreatic necrosis virus (IPNV) or Poly(I:C)', 'display_name': 'Protection of rainbow trout from infectious hematopoietic necrosis (IHN) by injection of infectious pancreatic necrosis virus (IPNV) or Poly(I:C)', 'publication_year': 2008, 'publication_date': '2008-11-03', 'ids': {'openalex': 'https://openalex.org/W1965108823', 'doi': 'https://doi.org/10.3354/dao02000', 'mag': '1965108823', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19326791'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3354/dao02000', 'pdf_url': 'https://www.int-res.com/articles/dao2008/83/d083p105.pdf', 'source': {'id': 'https://openalex.org/S49731288', 'display_name': 'Diseases of Aquatic Organisms', 'issn_l': '0177-5103', 'issn': ['0177-5103', '1616-1580'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310313773', 'host_organization_name': 'Inter-Research', 'host_organization_lineage': ['https://openalex.org/P4310313773'], 'host_organization_lineage_names': ['Inter-Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.int-res.com/articles/dao2008/83/d083p105.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5002712420', 'display_name': 'Hyung Jun Kim', 'orcid': 'https://orcid.org/0000-0001-8247-4004'}, 'institutions': [{'id': 'https://openalex.org/I205349734', 'display_name': 'Hokkaido University', 'ror': 'https://ror.org/02e16g702', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I205349734']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'HJ Kim', 'raw_affiliation_strings': ['Faculty of Fisheries Sciences, Hokkaido University, Hakodate 041-0811, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Faculty of Fisheries Sciences, Hokkaido University, Hakodate 041-0811, Japan.', 'institution_ids': ['https://openalex.org/I205349734']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113562422', 'display_name': 'Norihisa Oseko', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210117686', 'display_name': 'Japan Fisheries Research and Education Agency', 'ror': 'https://ror.org/02gmwvg31', 'country_code': 'JP', 'type': 'government', 'lineage': ['https://openalex.org/I4210117686']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'N Oseko', 'raw_affiliation_strings': ['National Research Institute of Aquaculture, Fisheries Research Agency, Sapporo, 062-0992, Japan'], 'affiliations': [{'raw_affiliation_string': 'National Research Institute of Aquaculture, Fisheries Research Agency, Sapporo, 062-0992, Japan', 'institution_ids': ['https://openalex.org/I4210117686']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113585563', 'display_name': 'T. Nishizawa', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I205349734', 'display_name': 'Hokkaido University', 'ror': 'https://ror.org/02e16g702', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I205349734']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'T Nishizawa', 'raw_affiliation_strings': ['Hokkaido University'], 'affiliations': [{'raw_affiliation_string': 'Hokkaido University', 'institution_ids': ['https://openalex.org/I205349734']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5112504418', 'display_name': 'Mamoru Yoshimizu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I205349734', 'display_name': 'Hokkaido University', 'ror': 'https://ror.org/02e16g702', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I205349734']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'M Yoshimizu', 'raw_affiliation_strings': ['Faculty of Fisheries Sciences, Hokkaido University, Hakodate, 041-0811, Japan'], 'affiliations': [{'raw_affiliation_string': 'Faculty of Fisheries Sciences, Hokkaido University, Hakodate, 041-0811, Japan', 'institution_ids': ['https://openalex.org/I205349734']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.169, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 67, 'citation_normalized_percentile': {'value': 0.999911, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '83', 'issue': None, 'first_page': '105', 'last_page': '113'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10506', 'display_name': 'Aquaculture disease management and microbiota', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10506', 'display_name': 'Aquaculture disease management and microbiota', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10450', 'display_name': 'Aquaculture Nutrition and Growth', 'score': 0.9854, 'subfield': {'id': 'https://openalex.org/subfields/1104', 'display_name': 'Aquatic Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11656', 'display_name': 'Turtle Biology and Conservation', 'score': 0.958, 'subfield': {'id': 'https://openalex.org/subfields/2309', 'display_name': 'Nature and Landscape Conservation'}, 'field': {'id': 'https://openalex.org/fields/23', 'display_name': 'Environmental Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2994167347', 'wikidata': 'https://www.wikidata.org/wiki/Q187986', 'display_name': 'Rainbow trout', 'level': 3, 'score': 0.91143155}, {'id': 'https://openalex.org/C2908884048', 'wikidata': 'https://www.wikidata.org/wiki/Q1662348', 'display_name': 'Infectious pancreatic necrosis virus', 'level': 3, 'score': 0.8716187}, {'id': 'https://openalex.org/C2778966499', 'wikidata': 'https://www.wikidata.org/wiki/Q880931', 'display_name': 'Infectious hematopoietic necrosis virus', 'level': 4, 'score': 0.81416583}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.78603095}, {'id': 'https://openalex.org/C503630168', 'wikidata': 'https://www.wikidata.org/wiki/Q178069', 'display_name': 'Necrosis', 'level': 2, 'score': 0.725664}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.6087292}, {'id': 'https://openalex.org/C109159458', 'wikidata': 'https://www.wikidata.org/wiki/Q919283', 'display_name': 'Haematopoiesis', 'level': 3, 'score': 0.5018246}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.48823217}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.38067284}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.37292483}, {'id': 'https://openalex.org/C2909208804', 'wikidata': 'https://www.wikidata.org/wiki/Q127282', 'display_name': 'Fish <Actinopterygii>', 'level': 2, 'score': 0.09417987}, {'id': 'https://openalex.org/C505870484', 'wikidata': 'https://www.wikidata.org/wiki/Q180538', 'display_name': 'Fishery', 'level': 1, 'score': 0.08056548}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.07553759}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D018175', 'descriptor_name': 'Birnaviridae Infections', 'qualifier_ui': 'Q000662', 'qualifier_name': 'veterinary', 'is_major_topic': True}, {'descriptor_ui': 'D005393', 'descriptor_name': 'Fish Diseases', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D018061', 'descriptor_name': 'Infectious pancreatic necrosis virus', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D011070', 'descriptor_name': 'Poly I-C', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000914', 'descriptor_name': 'Antibodies, Viral', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D000914', 'descriptor_name': 'Antibodies, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000998', 'descriptor_name': 'Antiviral Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018175', 'descriptor_name': 'Birnaviridae Infections', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018175', 'descriptor_name': 'Birnaviridae Infections', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D018175', 'descriptor_name': 'Birnaviridae Infections', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': False}, {'descriptor_ui': 'D005393', 'descriptor_name': 'Fish Diseases', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D005393', 'descriptor_name': 'Fish Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018061', 'descriptor_name': 'Infectious pancreatic necrosis virus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017686', 'descriptor_name': 'Oncorhynchus mykiss', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011070', 'descriptor_name': 'Poly I-C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3354/dao02000', 'pdf_url': 'https://www.int-res.com/articles/dao2008/83/d083p105.pdf', 'source': {'id': 'https://openalex.org/S49731288', 'display_name': 'Diseases of Aquatic Organisms', 'issn_l': '0177-5103', 'issn': ['0177-5103', '1616-1580'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310313773', 'host_organization_name': 'Inter-Research', 'host_organization_lineage': ['https://openalex.org/P4310313773'], 'host_organization_lineage_names': ['Inter-Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/2115/53180', 'pdf_url': 'https://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/53180/1/article151.pdf', 'source': {'id': 'https://openalex.org/S4306400549', 'display_name': 'Hokkaido University Collection of Scholarly and Academic Papers (Hokkaido University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I205349734', 'host_organization_name': 'Hokkaido University', 'host_organization_lineage': ['https://openalex.org/I205349734'], 'host_organization_lineage_names': ['Hokkaido University'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19326791', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3354/dao02000', 'pdf_url': 'https://www.int-res.com/articles/dao2008/83/d083p105.pdf', 'source': {'id': 'https://openalex.org/S49731288', 'display_name': 'Diseases of Aquatic Organisms', 'issn_l': '0177-5103', 'issn': ['0177-5103', '1616-1580'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310313773', 'host_organization_name': 'Inter-Research', 'host_organization_lineage': ['https://openalex.org/P4310313773'], 'host_organization_lineage_names': ['Inter-Research'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/14', 'display_name': 'Life below water', 'score': 0.85}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 41, 'referenced_works': ['https://openalex.org/W1605298882', 'https://openalex.org/W1691956316', 'https://openalex.org/W169719383', 'https://openalex.org/W176756961', 'https://openalex.org/W1819850974', 'https://openalex.org/W1884238430', 'https://openalex.org/W1966104961', 'https://openalex.org/W1969538236', 'https://openalex.org/W1971707588', 'https://openalex.org/W1972596648', 'https://openalex.org/W1972662881', 'https://openalex.org/W1989370133', 'https://openalex.org/W1995454320', 'https://openalex.org/W1997939418', 'https://openalex.org/W2001902704', 'https://openalex.org/W2003652678', 'https://openalex.org/W2007232879', 'https://openalex.org/W2010055142', 'https://openalex.org/W2016141188', 'https://openalex.org/W2018491032', 'https://openalex.org/W2022299095', 'https://openalex.org/W2027644118', 'https://openalex.org/W2036480532', 'https://openalex.org/W2044281825', 'https://openalex.org/W2054298846', 'https://openalex.org/W2083897499', 'https://openalex.org/W2096051806', 'https://openalex.org/W2106767166', 'https://openalex.org/W2109883473', 'https://openalex.org/W2115952550', 'https://openalex.org/W2132610700', 'https://openalex.org/W2151414133', 'https://openalex.org/W2162682122', 'https://openalex.org/W2184477031', 'https://openalex.org/W2235330381', 'https://openalex.org/W2333364234', 'https://openalex.org/W2418755526', 'https://openalex.org/W2467353425', 'https://openalex.org/W2604261003', 'https://openalex.org/W2773926078', 'https://openalex.org/W50774842'], 'related_works': ['https://openalex.org/W4287511593', 'https://openalex.org/W2954304474', 'https://openalex.org/W2800061740', 'https://openalex.org/W2735760257', 'https://openalex.org/W2585229605', 'https://openalex.org/W246476424', 'https://openalex.org/W2063386461', 'https://openalex.org/W2044281825', 'https://openalex.org/W1965108823', 'https://openalex.org/W1787953765'], 'abstract_inverted_index': {'It': [0], 'was': [1, 14, 36, 59], 'recently': [2], 'reported': [3], 'that': [4], 'prophylaxis': [5], 'against': [6], 'infectious': [7, 20], 'hematopoietic': [8], 'necrosis': [9, 22], 'virus': [10, 23], '(IHNV)': [11], 'in': [12, 31, 76, 101, 187], 'fish': [13, 109, 125, 232, 235], 'induced': [15, 191], 'by': [16, 38, 192], 'pre-exposure': [17], 'to': [18, 127, 208, 227], 'the': [19, 26, 68, 104, 120, 132, 180], 'pancreatic': [21], '(IPNV).': [24], 'Here': [25], 'establishment': [27], 'of': [28, 67, 206, 222, 231], 'IHNV': [29, 39, 86, 116, 122, 133, 148, 173, 182, 185, 196, 223], 'immunity': [30, 75, 130, 186], 'rainbow': [32, 188, 214], 'trout': [33, 79, 189, 215], 'Oncorhynchus': [34], 'mykiss': [35], 'investigated': [37], 'challenge': [40, 87, 134, 149, 193], 'following': [41, 135, 170, 197], 'non-lethal': [42], 'pre-infection': [43], 'with': [44, 81, 115, 137, 141, 172, 194, 199], 'IPNV.': [45, 138], 'Also,': [46], 'synthetic': [47], 'double-stranded': [48], 'RNA': [49], 'polyinosinic': [50], 'polycytidylic': [51], 'acid,': [52], 'Poly(I:C),': [53], 'an': [54, 210, 217], 'inducer': [55], 'for': [56, 64], 'interferon': [57], '(IFN),': [58], 'evaluated': [60], 'as': [61], 'a': [62, 166, 228], 'substitute': [63], 'IPNV': [65, 82, 201], 'induction': [66], 'non-specific': [69], 'antiviral': [70], 'state': [71, 212], 'and': [72, 96, 155, 176, 234], 'subsequent': [73], 'IHNV-specific': [74, 97, 129, 156], 'fish.': [77], 'Rainbow': [78], 'pre-infected': [80], 'were': [83, 99, 143, 158], 'protected': [84, 146], 'from': [85, 103, 147, 216], '7': [88], 'd': [89, 118, 151, 178], 'later': [90, 152], '(relative': [91], 'percentage': [92], 'survival,': [93], 'RPS:': [94], '68.8%),': [95], 'antibodies': [98, 157], 'detected': [100, 160], 'sera': [102], 'survivors.': [105, 162], 'Moreover,': [106], 'these': [107], 'surviving': [108], 'showed': [110, 165], '91.6%': [111], 'RPS': [112], 'when': [113], 're-challenged': [114], '28': [117], 'after': [119, 179], 'primary': [121, 181], 'challenge.': [123, 183], 'Thus,': [124, 184], 'appear': [126], 'acquire': [128], 'through': [131], 'pre-injection': [136, 198], 'Fish': [139], 'pre-injected': [140], 'Poly(I:C)': [142, 207], 'also': [144, 159], 'highly': [145], '2': [150], '(RPS:': [153], '95.2%),': [154], 'amongst': [161], 'The': [163, 204], 'survivors': [164], '100%': [167], 'survival': [168], 'rate': [169], 're-challenge': [171], 'both': [174], '21': [175], '49': [177], 'is': [190], 'live': [195], 'either': [200], 'or': [202], 'Poly(I:C).': [203], 'use': [205], 'induce': [209], 'anti-viral': [211], 'protecting': [213], 'otherwise': [218], 'lethal': [219], 'vaccination': [220], 'dose': [221], 'may': [224], 'have': [225], 'application': [226], 'wider': [229], 'range': [230], 'species': [233], 'pathogenic': [236], 'viruses.': [237]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1965108823', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 7}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-12-14T22:21:52.032321', 'created_date': '2016-06-24'}