Genome-wide identification of post-translational modulators of transcription factor activity in human B cells

Name: Work Video:
Duration: 3 min 30 s
Kai Wang; Masumichi Saito; Brygida Bisikirska; Mariano J. Alvarez; Wei Keat Lim; Presha Rajbhandari; Qiong Shen; Ilya Nemenman; Katia Basso; Adam A. Margolin; Ulf Klein; Riccardo Dalla‐Favera; Andrea Califano
{'id': 'https://openalex.org/W1965032353', 'doi': 'https://doi.org/10.1038/nbt.1563', 'title': 'Genome-wide identification of post-translational modulators of transcription factor activity in human B cells', 'display_name': 'Genome-wide identification of post-translational modulators of transcription factor activity in human B cells', 'publication_year': 2009, 'publication_date': '2009-09-01', 'ids': {'openalex': 'https://openalex.org/W1965032353', 'doi': 'https://doi.org/10.1038/nbt.1563', 'mag': '1965032353', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/19741643', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2753889'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/nbt.1563', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S106963461', 'display_name': 'Nature Biotechnology', 'issn_l': '1087-0156', 'issn': ['1087-0156', '1546-1696'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc2753889?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100774874', 'display_name': 'Kai Wang', 'orcid': 'https://orcid.org/0000-0003-0567-3004'}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Kai Wang', 'raw_affiliation_strings': ['Department of Biomedical Informatics, Columbia University, New York, New York, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biomedical Informatics, Columbia University, New York, New York, USA.', 'institution_ids': ['https://openalex.org/I78577930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011453635', 'display_name': 'Masumichi Saito', 'orcid': 'https://orcid.org/0000-0001-7187-1186'}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}, {'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Masumichi Saito', 'raw_affiliation_strings': ['Emory University, Atlanta, United States', 'Institute of Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Columbia University, New York, USA'], 'affiliations': [{'raw_affiliation_string': 'Institute of Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Columbia University, New York, USA', 'institution_ids': ['https://openalex.org/I78577930']}, {'raw_affiliation_string': 'Emory University, Atlanta, United States', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065478673', 'display_name': 'Brygida Bisikirska', 'orcid': 'https://orcid.org/0000-0002-4681-2827'}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Brygida C. Bisikirska', 'raw_affiliation_strings': ['Joint Centers for Systems Biology, Columbia University,New York,USA'], 'affiliations': [{'raw_affiliation_string': 'Joint Centers for Systems Biology, Columbia University,New York,USA', 'institution_ids': ['https://openalex.org/I78577930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017756904', 'display_name': 'Mariano J. Alvarez', 'orcid': 'https://orcid.org/0000-0002-7503-2491'}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mariano J. Alvarez', 'raw_affiliation_strings': ['Joint Centers for Systems Biology, Columbia University,New York,USA'], 'affiliations': [{'raw_affiliation_string': 'Joint Centers for Systems Biology, Columbia University,New York,USA', 'institution_ids': ['https://openalex.org/I78577930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087635680', 'display_name': 'Wei Keat Lim', 'orcid': 'https://orcid.org/0000-0002-6226-2570'}, 'institutions': [{'id': 'https://openalex.org/I4210155419', 'display_name': 'Center for Systems Biology', 'ror': 'https://ror.org/05r3dyn47', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I136199984', 'https://openalex.org/I4210087915', 'https://openalex.org/I4210155419', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}, {'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wei Keat Lim', 'raw_affiliation_strings': ['Emory University, Atlanta, United States', 'Joint Centers for Systems Biology, Columbia University, New York, USA'], 'affiliations': [{'raw_affiliation_string': 'Joint Centers for Systems Biology, Columbia University, New York, USA', 'institution_ids': ['https://openalex.org/I4210155419', 'https://openalex.org/I78577930']}, {'raw_affiliation_string': 'Emory University, Atlanta, United States', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005730011', 'display_name': 'Presha Rajbhandari', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Presha Rajbhandari', 'raw_affiliation_strings': ['Joint Centers for Systems Biology, Columbia University,New York,USA'], 'affiliations': [{'raw_affiliation_string': 'Joint Centers for Systems Biology, Columbia University,New York,USA', 'institution_ids': ['https://openalex.org/I78577930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057851288', 'display_name': 'Qiong Shen', 'orcid': 'https://orcid.org/0000-0001-6313-3642'}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Qiong Shen', 'raw_affiliation_strings': ['Institute of Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Columbia University, New York, USA'], 'affiliations': [{'raw_affiliation_string': 'Institute of Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Columbia University, New York, USA', 'institution_ids': ['https://openalex.org/I78577930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071388278', 'display_name': 'Ilya Nemenman', 'orcid': 'https://orcid.org/0000-0003-3024-4244'}, 'institutions': [{'id': 'https://openalex.org/I4210155419', 'display_name': 'Center for Systems Biology', 'ror': 'https://ror.org/05r3dyn47', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I136199984', 'https://openalex.org/I4210087915', 'https://openalex.org/I4210155419', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}, {'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ilya Nemenman', 'raw_affiliation_strings': ['Emory University, Atlanta, United States', 'Joint Centers for Systems Biology, Columbia University, New York, USA'], 'affiliations': [{'raw_affiliation_string': 'Joint Centers for Systems Biology, Columbia University, New York, USA', 'institution_ids': ['https://openalex.org/I4210155419', 'https://openalex.org/I78577930']}, {'raw_affiliation_string': 'Emory University, Atlanta, United States', 'institution_ids': ['https://openalex.org/I150468666']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071634974', 'display_name': 'Katia Basso', 'orcid': 'https://orcid.org/0000-0002-9316-6039'}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Katia Basso', 'raw_affiliation_strings': ['Institute of Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Columbia University, New York, USA'], 'affiliations': [{'raw_affiliation_string': 'Institute of Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Columbia University, New York, USA', 'institution_ids': ['https://openalex.org/I78577930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011346527', 'display_name': 'Adam A. Margolin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I150468666', 'display_name': 'Emory University', 'ror': 'https://ror.org/03czfpz43', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I150468666']}, {'id': 'https://openalex.org/I4210155419', 'display_name': 'Center for Systems Biology', 'ror': 'https://ror.org/05r3dyn47', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I136199984', 'https://openalex.org/I4210087915', 'https://openalex.org/I4210155419', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Adam A. Margolin', 'raw_affiliation_strings': ['Emory University, Atlanta, United States', 'Joint Centers for Systems Biology, Columbia University, New York, USA'], 'affiliations': [{'raw_affiliation_string': 'Emory University, Atlanta, United States', 'institution_ids': ['https://openalex.org/I150468666']}, {'raw_affiliation_string': 'Joint Centers for Systems Biology, Columbia University, New York, USA', 'institution_ids': ['https://openalex.org/I4210155419', 'https://openalex.org/I78577930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057518210', 'display_name': 'Ulf Klein', 'orcid': 'https://orcid.org/0000-0002-4789-967X'}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ulf Klein', 'raw_affiliation_strings': ['Institute of Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Columbia University, New York, USA'], 'affiliations': [{'raw_affiliation_string': 'Institute of Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Columbia University, New York, USA', 'institution_ids': ['https://openalex.org/I78577930']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012955086', 'display_name': 'Riccardo Dalla‐Favera', 'orcid': 'https://orcid.org/0000-0002-3502-8826'}, 'institutions': [{'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Riccardo Dalla-Favera', 'raw_affiliation_strings': ['Institute of Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Columbia University, New York, USA'], 'affiliations': [{'raw_affiliation_string': 'Institute of Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Columbia University, New York, USA', 'institution_ids': ['https://openalex.org/I78577930']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5046245448', 'display_name': 'Andrea Califano', 'orcid': 'https://orcid.org/0000-0003-4742-3679'}, 'institutions': [{'id': 'https://openalex.org/I4210155419', 'display_name': 'Center for Systems Biology', 'ror': 'https://ror.org/05r3dyn47', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I136199984', 'https://openalex.org/I4210087915', 'https://openalex.org/I4210155419', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I78577930', 'display_name': 'Columbia University', 'ror': 'https://ror.org/00hj8s172', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I78577930']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Andrea Califano', 'raw_affiliation_strings': ['Joint Centers for Systems Biology, Columbia University, New York, USA'], 'affiliations': [{'raw_affiliation_string': 'Joint Centers for Systems Biology, Columbia University, New York, USA', 'institution_ids': ['https://openalex.org/I4210155419', 'https://openalex.org/I78577930']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 9750, 'currency': 'EUR', 'value_usd': 11690, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 7.127, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 238, 'citation_normalized_percentile': {'value': 0.914985, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '27', 'issue': '9', 'first_page': '829', 'last_page': '837'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10031', 'display_name': 'T-cell and B-cell Immunology', 'score': 0.9953, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10031', 'display_name': 'T-cell and B-cell Immunology', 'score': 0.9953, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10621', 'display_name': 'Gene Regulatory Network Analysis', 'score': 0.9953, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10222', 'display_name': 'Genomics and Chromatin Dynamics', 'score': 0.9937, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/transcription', 'display_name': 'Transcription', 'score': 0.4133398}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7068859}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.69290507}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.6198538}, {'id': 'https://openalex.org/C41091548', 'wikidata': 'https://www.wikidata.org/wiki/Q26939', 'display_name': 'Epigenetics', 'level': 3, 'score': 0.51137775}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.45955053}, {'id': 'https://openalex.org/C165864922', 'wikidata': 'https://www.wikidata.org/wiki/Q411391', 'display_name': 'Regulation of gene expression', 'level': 3, 'score': 0.45827863}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.42723477}, {'id': 'https://openalex.org/C2779343474', 'wikidata': 'https://www.wikidata.org/wiki/Q3109175', 'display_name': 'Context (archaeology)', 'level': 2, 'score': 0.42191535}, {'id': 'https://openalex.org/C179926584', 'wikidata': 'https://www.wikidata.org/wiki/Q207714', 'display_name': 'Transcription (linguistics)', 'level': 2, 'score': 0.4133398}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.39426658}, {'id': 'https://openalex.org/C151730666', 'wikidata': 'https://www.wikidata.org/wiki/Q7205', 'display_name': 'Paleontology', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C41895202', 'wikidata': 'https://www.wikidata.org/wiki/Q8162', 'display_name': 'Linguistics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C138885662', 'wikidata': 'https://www.wikidata.org/wiki/Q5891', 'display_name': 'Philosophy', 'level': 0, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000465', 'descriptor_name': 'Algorithms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D001402', 'descriptor_name': 'B-Lymphocytes', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D008957', 'descriptor_name': 'Models, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011499', 'descriptor_name': 'Protein Processing, Post-Translational', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D016271', 'descriptor_name': 'Proto-Oncogene Proteins c-myc', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D001402', 'descriptor_name': 'B-Lymphocytes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001402', 'descriptor_name': 'B-Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051792', 'descriptor_name': 'Basic Helix-Loop-Helix Transcription Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051792', 'descriptor_name': 'Basic Helix-Loop-Helix Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D051792', 'descriptor_name': 'Basic Helix-Loop-Helix Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056284', 'descriptor_name': 'Histone Deacetylase 1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D056284', 'descriptor_name': 'Histone Deacetylase 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D056284', 'descriptor_name': 'Histone Deacetylase 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018398', 'descriptor_name': 'Homeodomain Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018398', 'descriptor_name': 'Homeodomain Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018398', 'descriptor_name': 'Homeodomain Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D026161', 'descriptor_name': 'MADS Domain Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D026161', 'descriptor_name': 'MADS Domain Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D026161', 'descriptor_name': 'MADS Domain Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D064326', 'descriptor_name': 'MEF2 Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046228', 'descriptor_name': 'Microarray Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018006', 'descriptor_name': 'Myogenic Regulatory Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D018006', 'descriptor_name': 'Myogenic Regulatory Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018006', 'descriptor_name': 'Myogenic Regulatory Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011499', 'descriptor_name': 'Protein Processing, Post-Translational', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055550', 'descriptor_name': 'Protein Stability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein-Serine-Threonine Kinases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein-Serine-Threonine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein-Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016271', 'descriptor_name': 'Proto-Oncogene Proteins c-myc', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016271', 'descriptor_name': 'Proto-Oncogene Proteins c-myc', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015203', 'descriptor_name': 'Reproducibility of Results', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049490', 'descriptor_name': 'Systems Biology', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D049490', 'descriptor_name': 'Systems Biology', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/nbt.1563', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S106963461', 'display_name': 'Nature Biotechnology', 'issn_l': '1087-0156', 'issn': ['1087-0156', '1546-1696'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2753889', 'pdf_url': 'https://europepmc.org/articles/pmc2753889?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2753889', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/19741643', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc2753889', 'pdf_url': 'https://europepmc.org/articles/pmc2753889?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 52, 'referenced_works': ['https://openalex.org/W1547608553', 'https://openalex.org/W1589053023', 'https://openalex.org/W1964742508', 'https://openalex.org/W1964895626', 'https://openalex.org/W1968758858', 'https://openalex.org/W1976874039', 'https://openalex.org/W1982598635', 'https://openalex.org/W1993456041', 'https://openalex.org/W1996212879', 'https://openalex.org/W2009761723', 'https://openalex.org/W2009859686', 'https://openalex.org/W2012538791', 'https://openalex.org/W2017340736', 'https://openalex.org/W2037174767', 'https://openalex.org/W2044525257', 'https://openalex.org/W2059699217', 'https://openalex.org/W2060029740', 'https://openalex.org/W2062348957', 'https://openalex.org/W2062867942', 'https://openalex.org/W2066663722', 'https://openalex.org/W2070672503', 'https://openalex.org/W2074370114', 'https://openalex.org/W2076372398', 'https://openalex.org/W2076543297', 'https://openalex.org/W2076721268', 'https://openalex.org/W2080831931', 'https://openalex.org/W2081973434', 'https://openalex.org/W2082213640', 'https://openalex.org/W2099111195', 'https://openalex.org/W2106119346', 'https://openalex.org/W2109248504', 'https://openalex.org/W2110894784', 'https://openalex.org/W2118628540', 'https://openalex.org/W2121963546', 'https://openalex.org/W2123775239', 'https://openalex.org/W2125631472', 'https://openalex.org/W2127634027', 'https://openalex.org/W2130410032', 'https://openalex.org/W2131532450', 'https://openalex.org/W2144449731', 'https://openalex.org/W2147054306', 'https://openalex.org/W2150729931', 'https://openalex.org/W2161409973', 'https://openalex.org/W2162142896', 'https://openalex.org/W2163296115', 'https://openalex.org/W2166898290', 'https://openalex.org/W2167190345', 'https://openalex.org/W2168783124', 'https://openalex.org/W2478708596', 'https://openalex.org/W3099289621', 'https://openalex.org/W3211630204', 'https://openalex.org/W4248318091'], 'related_works': ['https://openalex.org/W4380318195', 'https://openalex.org/W4366603091', 'https://openalex.org/W3093680309', 'https://openalex.org/W2485141070', 'https://openalex.org/W2411374999', 'https://openalex.org/W2325094346', 'https://openalex.org/W2115260093', 'https://openalex.org/W2083798468', 'https://openalex.org/W2008978345', 'https://openalex.org/W1985722377'], 'abstract_inverted_index': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1965032353', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 14}, {'year': 2020, 'cited_by_count': 16}, {'year': 2019, 'cited_by_count': 16}, {'year': 2018, 'cited_by_count': 14}, {'year': 2017, 'cited_by_count': 20}, {'year': 2016, 'cited_by_count': 15}, {'year': 2015, 'cited_by_count': 27}, {'year': 2014, 'cited_by_count': 22}, {'year': 2013, 'cited_by_count': 18}, {'year': 2012, 'cited_by_count': 28}], 'updated_date': '2025-01-08T18:03:59.033618', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
