Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1965011142', 'doi': 'https://doi.org/10.1517/14712598.3.6.941', 'title': 'Gene therapy of monogenic and cardiovascular disorders', 'display_name': 'Gene therapy of monogenic and cardiovascular disorders', 'publication_year': 2003, 'publication_date': '2003-09-01', 'ids': {'openalex': 'https://openalex.org/W1965011142', 'doi': 'https://doi.org/10.1517/14712598.3.6.941', 'mag': '1965011142', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12943453'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1517/14712598.3.6.941', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S57380513', 'display_name': 'Expert Opinion on Biological Therapy', 'issn_l': '1471-2598', 'issn': ['1471-2598', '1744-7682'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5000628111', 'display_name': 'Pontus Blomberg', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Pontus Blomberg', 'raw_affiliation_strings': ['Clinical Research Center, Karolinska Institutet, Huddinge University Hospital, SE-141 86 Stockholm, Sweden. [email protected]'], 'affiliations': [{'raw_affiliation_string': 'Clinical Research Center, Karolinska Institutet, Huddinge University Hospital, SE-141 86 Stockholm, Sweden. [email protected]', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5036357426', 'display_name': 'Smith Rjh', 'orcid': 'https://orcid.org/0000-0003-1907-3392'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'CI Edvard Smith', 'raw_affiliation_strings': ['Clinical Research Center, Karolinska Institutet, Huddinge University Hospital, SE-141 86 Stockholm, Sweden. [email protected]'], 'affiliations': [{'raw_affiliation_string': 'Clinical Research Center, Karolinska Institutet, Huddinge University Hospital, SE-141 86 Stockholm, Sweden. [email protected]', 'institution_ids': ['https://openalex.org/I28166907']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.039, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 8, 'citation_normalized_percentile': {'value': 0.161523, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 78, 'max': 79}, 'biblio': {'volume': '3', 'issue': '6', 'first_page': '941', 'last_page': '949'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10878', 'display_name': 'CRISPR and Genetic Engineering', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10878', 'display_name': 'CRISPR and Genetic Engineering', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10613', 'display_name': 'Virus-based gene therapy research', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10505', 'display_name': 'Pluripotent Stem Cells Research', 'score': 0.9846, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/gene-transfer', 'display_name': 'Gene transfer', 'score': 0.6591691}], 'concepts': [{'id': 'https://openalex.org/C111599444', 'wikidata': 'https://www.wikidata.org/wiki/Q213901', 'display_name': 'Genetic enhancement', 'level': 3, 'score': 0.81454515}, {'id': 'https://openalex.org/C3018928802', 'wikidata': 'https://www.wikidata.org/wiki/Q83185', 'display_name': 'Gene transfer', 'level': 3, 'score': 0.6591691}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.54345274}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.4761562}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.46764633}, {'id': 'https://openalex.org/C535046627', 'wikidata': 'https://www.wikidata.org/wiki/Q30612', 'display_name': 'Clinical trial', 'level': 2, 'score': 0.46148932}, {'id': 'https://openalex.org/C177713679', 'wikidata': 'https://www.wikidata.org/wiki/Q679690', 'display_name': 'Intensive care medicine', 'level': 1, 'score': 0.4312637}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.42732787}, {'id': 'https://openalex.org/C135983454', 'wikidata': 'https://www.wikidata.org/wiki/Q2790163', 'display_name': 'Gene delivery', 'level': 4, 'score': 0.41414434}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.33099008}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.27821183}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.23601672}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.13093278}], 'mesh': [{'descriptor_ui': 'D002318', 'descriptor_name': 'Cardiovascular Diseases', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': True}, {'descriptor_ui': 'D015316', 'descriptor_name': 'Genetic Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000260', 'descriptor_name': 'Adenoviruses, Human', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000260', 'descriptor_name': 'Adenoviruses, Human', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002318', 'descriptor_name': 'Cardiovascular Diseases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018014', 'descriptor_name': 'Gene Transfer Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005822', 'descriptor_name': 'Genetic Vectors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006937', 'descriptor_name': 'Hypercholesterolemia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006937', 'descriptor_name': 'Hypercholesterolemia', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': False}, {'descriptor_ui': 'D006937', 'descriptor_name': 'Hypercholesterolemia', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': 'Q000628', 'qualifier_name': 'therapy', 'is_major_topic': False}, {'descriptor_ui': 'D006973', 'descriptor_name': 'Hypertension', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1517/14712598.3.6.941', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S57380513', 'display_name': 'Expert Opinion on Biological Therapy', 'issn_l': '1471-2598', 'issn': ['1471-2598', '1744-7682'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12943453', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.75, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 56, 'referenced_works': ['https://openalex.org/W1491615287', 'https://openalex.org/W1523649511', 'https://openalex.org/W1549673200', 'https://openalex.org/W1599588446', 'https://openalex.org/W1611419331', 'https://openalex.org/W172616549', 'https://openalex.org/W1973905531', 'https://openalex.org/W1974168498', 'https://openalex.org/W1975406089', 'https://openalex.org/W1989710477', 'https://openalex.org/W1992346069', 'https://openalex.org/W1998165633', 'https://openalex.org/W2002111141', 'https://openalex.org/W2003306608', 'https://openalex.org/W2014356856', 'https://openalex.org/W2014495927', 'https://openalex.org/W2015789556', 'https://openalex.org/W2019350996', 'https://openalex.org/W2027022352', 'https://openalex.org/W2032678451', 'https://openalex.org/W2043852940', 'https://openalex.org/W2053706156', 'https://openalex.org/W2058363899', 'https://openalex.org/W2062673895', 'https://openalex.org/W2066271426', 'https://openalex.org/W2069934604', 'https://openalex.org/W2070287179', 'https://openalex.org/W2075545024', 'https://openalex.org/W2079419386', 'https://openalex.org/W2080225080', 'https://openalex.org/W2083354706', 'https://openalex.org/W2083922905', 'https://openalex.org/W2087548718', 'https://openalex.org/W2089579355', 'https://openalex.org/W2089865394', 'https://openalex.org/W2090300064', 'https://openalex.org/W2091268360', 'https://openalex.org/W2091401760', 'https://openalex.org/W2092246905', 'https://openalex.org/W2107278930', 'https://openalex.org/W2117208578', 'https://openalex.org/W2124715674', 'https://openalex.org/W2126466006', 'https://openalex.org/W2130515212', 'https://openalex.org/W2135135539', 'https://openalex.org/W2136812723', 'https://openalex.org/W2143729842', 'https://openalex.org/W2144266543', 'https://openalex.org/W2146518428', 'https://openalex.org/W2147074779', 'https://openalex.org/W2152738960', 'https://openalex.org/W2163192616', 'https://openalex.org/W2319307281', 'https://openalex.org/W2323613689', 'https://openalex.org/W3151452517', 'https://openalex.org/W4254038279'], 'related_works': ['https://openalex.org/W623520303', 'https://openalex.org/W612523068', 'https://openalex.org/W2364423915', 'https://openalex.org/W2284231492', 'https://openalex.org/W2267148874', 'https://openalex.org/W2144336433', 'https://openalex.org/W2079987784', 'https://openalex.org/W2054739272', 'https://openalex.org/W1602083480', 'https://openalex.org/W1587611090'], 'abstract_inverted_index': {'The': [0, 36], 'concept': [1], 'of': [2, 8, 20, 71, 94, 113], 'gene': [3, 27, 39, 78, 86, 119], 'therapy': [4, 40, 120], 'involves': [5], 'the': [6, 18, 31, 44, 62, 66, 85, 92, 133], 'introduction': [7], 'genetic': [9, 95, 115], 'material': [10, 96], 'into': [11], 'patient': [12], 'cells': [13], 'to': [14], 'cure': [15], 'or': [16, 28, 89], 'alleviate': [17], 'symptoms': [19], 'a': [21, 25, 33, 69], 'disease': [22], 'by': [23, 29], 'complementing': [24], 'damaged': [26], 'giving': [30], 'cell': [32], 'new': [34], 'function.': [35], 'belief': [37], 'that': [38, 77, 84, 101], 'would': [41], 'soon': [42], 'reach': [43], 'clinic': [45], 'has': [46, 74, 125], 'been': [47, 126], 'widely': [48], 'spread,': [49], 'frequently': [50], 'resulting': [51], 'in': [52], 'controversies': [53], 'when': [54], 'these': [55], 'expectations': [56], 'were': [57], 'not': [58], 'met.': [59], 'Nevertheless,': [60], 'over': [61], 'last': [63], '10-year': [64], 'period,': [65], 'experience': [67], 'from': [68], 'number': [70], 'clinical': [72], 'trials': [73], 'taught': [75], 'us': [76], 'transfer': [79, 93], 'is': [80, 121], 'technically': [81], 'feasible,': [82], 'but': [83], 'delivery': [87], 'vehicles,': [88], 'vectors,': [90], 'for': [91, 117], 'are': [97], 'still': [98], 'suboptimal': [99], 'and': [100, 124, 137, 141], 'treatment': [102], 'may': [103], 'have': [104], 'severe': [105], 'side': [106], 'effects.': [107], 'This': [108], 'review': [109], 'will': [110, 129], 'provide': [111], 'examples': [112], 'different': [114], 'disorders': [116], 'which': [118], 'an': [122], 'option': [123], 'attempted.': [127], 'It': [128], 'also': [130], 'briefly': [131], 'discuss': [132], 'existing': [134], 'vector': [135], 'systems': [136], 'mention': [138], 'their': [139], 'advantages': [140], 'drawbacks.': [142]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1965011142', 'counts_by_year': [{'year': 2014, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-09T10:30:11.070181', 'created_date': '2016-06-24'}