Title: Effect of repeated sauna therapy on survival in TO-2 cardiomyopathic hamsters with heart failure
Abstract: Several clinical and experimental studies have shown that vascular endothelial function is impaired in chronic congestive heart failure (CHF), leading to vasoconstriction and clinical symptoms. 1 Katz S.D. Mechanisms and implications of endothelial dysfunction in congestive heart failure. Curr Opin Cardiol. 1997; 12: 259-264 Crossref PubMed Scopus (72) Google Scholar We have recently reported that repeated sauna therapy using 60°C sauna, a new nonpharmacologic thermal vasodilation therapy, induces vasodilation of the systemic and pulmonary arteries and veins, reduces car-diac preload and afterload, and improves hemodynamics and clinical symptoms in patients with CHF, 2 Tei C. Horikiri Y. Park J.C. Jeong J.W. Chang K.S. Toyama Y. Tanaka N. Acute hemodynamic improvement by thermal vasodilation in congestive heart failure. Circulation. 1995; 91: 2582-2590 Crossref PubMed Scopus (222) Google Scholar , 3 Kihara T. Biro S. Imamura M. Yoshifuku S. Takasaki K. Ikeda Y. Otsuji Y. Minagoe S. Toyama Y. Tei C. Repeated sauna treatment improves vascularendothelial and cardiac function in patients with chronic heart failure. J Am Coll Cardiol. 2002; 39: 754-759 Crossref PubMed Scopus (206) Google Scholar probably due to improvement in vascular endothelial dysfunction 3 Kihara T. Biro S. Imamura M. Yoshifuku S. Takasaki K. Ikeda Y. Otsuji Y. Minagoe S. Toyama Y. Tei C. Repeated sauna treatment improves vascularendothelial and cardiac function in patients with chronic heart failure. J Am Coll Cardiol. 2002; 39: 754-759 Crossref PubMed Scopus (206) Google Scholar , 4 Imamura M. Biro S. Kihara T. Yoshifuku S. Takasaki K. Otsuji Y. Minagoe S. Toyama Y. Tei C. Repeated thermal therapy improves impaired vascular endothelial function in patients with coronary risk factors. J Am Coll Cardiol. 2001; 38: 1083-1088 Crossref PubMed Scopus (199) Google Scholar , 5 Ikeda Y. Biro S. Kamogawa Y. Yoshifuku S. Eto H. Orihara K. Kihara T. Tei C. Repeated thermal therapy upregulates arterial endothelial nitric oxide synthase expression in Syrian golden hamsters. Jpn Circ J. 2001; 65: 434-438 Crossref PubMed Scopus (65) Google Scholar and abnormality of neurohormonal systems. 2 Tei C. Horikiri Y. Park J.C. Jeong J.W. Chang K.S. Toyama Y. Tanaka N. Acute hemodynamic improvement by thermal vasodilation in congestive heart failure. Circulation. 1995; 91: 2582-2590 Crossref PubMed Scopus (222) Google Scholar , 3 Kihara T. Biro S. Imamura M. Yoshifuku S. Takasaki K. Ikeda Y. Otsuji Y. Minagoe S. Toyama Y. Tei C. Repeated sauna treatment improves vascularendothelial and cardiac function in patients with chronic heart failure. J Am Coll Cardiol. 2002; 39: 754-759 Crossref PubMed Scopus (206) Google Scholar Therefore, we sought to determine whether repeated sauna therapy improves prognosis in CHF. Because it is difficult to evaluate the precise clinical effect of single treatment on survival in patients with CHF, we investigated whether repeated sauna therapy improves survival in CHF using cardiomyopathic hamsters.
Publication Year: 2002
Publication Date: 2002-08-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 25
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