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1400, 1416, 1443, 1456, 1461, 1473, 1503, 1537, 1600, 1643, 1668, 1688, 1696, 1731, 1849, 1916, 2003, 2086, 2111, 2128, 2169, 2182], 'early': [22, 472, 2087, 2112], 'nodular': [23, 46, 153, 473, 1437, 1475, 2088, 2113], 'carcinomas': [26, 714], '(BCCs;': [27], 'Smucler': [28, 60], 'Vlk,': [30, 137], '2008Smucler': [31, 138], 'R.': [32, 64, 139, 957], 'Vlk': [33, 140], 'M.': [34, 66, 141, 462, 2077], 'Combination': [35, 142], 'Er:YAG': [37, 144, 546, 772, 1001], 'laser': [38, 145, 256, 373, 427, 467, 773, 960, 1296, 1314, 2082], 'photodynamic': [40, 74, 147], 'therapy': [41, 75, 148], 'in': [42, 96, 99, 149, 260, 297, 399, 448, 490, 682, 715, 822, 905, 941, 1022, 1024, 1072, 1168, 1229, 1494, 1563, 1573, 1597, 1628, 1685, 1711, 1726, 1735, 1812, 1867, 1923], 'the': [43, 106, 150, 253, 377, 386, 395, 494, 580, 641, 755, 839, 851, 855, 918, 924, 931, 939, 1051, 1060, 1073, 1094, 1105, 1109, 1112, 1203, 1207, 1244, 1270, 1273, 1276, 1340, 1352, 1358, 1364, 1371, 1407, 1411, 1414, 1420, 1430, 1450, 1474, 1478, 1492, 1495, 1516, 1519, 1532, 1535, 1539, 1553, 1556, 1559, 1569, 1574, 1577, 1585, 1588, 1593, 1601, 1608, 1616, 1619, 1624, 1634, 1674, 1678, 1681, 1694, 1697, 1705, 1709, 1732, 1754, 1765, 1818, 1823, 1826, 1830, 2102, 2133, 2150, 2188], 'treatment': [44, 151, 187, 220, 1749], 'carcinoma.Lasers': [49, 156], 'Surg': [50, 157, 556, 974, 1011], 'Med.': [51, 158, 557, 975, 1012], '2008;': [52, 159], '40:': [53, 160], '153-158Crossref': [54, 161], 'PubMed': [55, 86, 162, 200, 240, 318, 366, 481, 561, 979, 1016, 1807, 1944, 1980, 2028, 2063, 2096], 'Scopus': [56, 87, 163, 201, 241, 319, 367, 443, 482, 562, 725, 980, 1017, 1330, 1808, 1945, 1981, 2029, 2064, 2097], '(63)': [57, 164], 'Google': [58, 89, 165, 203, 243, 321, 369, 445, 484, 564, 727, 982, 1019, 1332, 1810, 1903, 1947, 1983, 2031, 2066, 2099], 'Scholar;': [59, 204, 322, 983, 1904, 1948, 1984, 2032, 2067], 'et': [61, 69, 176, 184, 206, 214, 280, 288, 324, 332, 411, 419, 454, 463, 530, 538, 699, 707, 950, 958, 985, 993, 1298, 1306, 1778, 1786, 1870, 1906, 1914, 1950, 1958, 1986, 1994, 2034, 2042, 2069, 2078], 'al.,': [62, 177, 207, 281, 325, 412, 455, 531, 700, 951, 986, 1299, 1779, 1871, 1907, 1951, 1987, 2035, 2070], '2012Smucler': [63], 'Kriz': [65], 'Lippert': [67], 'J.': [68, 287, 458, 1913, 2073], 'al.Ultrasound': [70], 'guided': [71, 466, 2081], 'ablative-laser': [72], 'assisted': [73], '(US-aL-PDT).Photomed': [80], 'Surg.': [82, 1803, 1899, 2059], '2012;': [83, 358, 1804, 2020, 2060], '30:': [84], '200-205Crossref': [85], '(22)': [88], 'Scholar).': [90, 565, 728, 1020], 'The': [91, 124, 678, 866, 1160, 1177, 1216, 1263, 1566, 1631, 1720, 2135], 'skin': [92, 190, 401, 542, 718, 756, 997, 1095], 'can': [93, 1054], 'be': [94, 128, 928, 936, 1086, 1640, 1840, 2138, 2158], 'removed': [95], 'μm-thin': [97], 'layers': [98], 'well-controlled': [101], 'manner,': [102], 'increasing': [103], 'preservation': [104], 'surrounding': [107, 863, 932], 'normal': [108], 'tissue.': [109, 492], 'However,': [110, 493, 1021, 1822], 'tissue': [111, 572, 679, 915, 969, 1651], 'vaporized': [113], 'such': [114, 273, 2143], 'that': [115, 169, 518, 569, 842, 869, 1387, 1743], 'there': [116], 'none': [118], 'available': [119, 1139], 'immediate': [121, 390], 'histopathological': [122], 'confirmation.': [123], 'efficacy': [125, 2151], 'tends': [126], 'to': [127, 388, 393, 422, 575, 743, 758, 876, 938, 1058, 1309, 1369, 1531, 1584, 1607, 1615, 1639, 1677, 1814, 1839, 2115, 2160], 'variable': [129, 498], 'recurrence': [131, 216, 2170], 'rate': [132, 1191, 2171], '(8.25%)': [133], 'low': [134, 1655], '(Smucler': [135], 'Scholar),': [166, 244, 2100], 'compared': [167, 1194], 'with': [168, 404, 450, 503, 512, 544, 599, 770, 944, 999, 1029, 1125, 1137, 1151, 1195, 1212, 1235, 1243, 1280, 1292, 1394, 1758, 1864, 2140, 2178], 'reported': [170], 'Mohs': [172, 668, 716, 1888], 'surgery': [173, 669, 1890], '(2.1–3.5%;': [174], 'Chren': [175, 205], '2011Chren': [178], 'M.M.': [179, 209], 'Torres': [180, 212, 1874], 'J.S.': [181, 213], 'Stuart': [182], 'S.E.': [183], 'al.Recurrence': [185], 'after': [186, 219, 1116], 'nonmelanoma': [189], 'cancer:': [191], 'prospective': [193], 'cohort': [194], 'study.Arch': [195], 'Dermatol.': [196, 231, 309, 357, 477, 1935, 1976, 2019, 2092], '2011;': [197], '147:': [198], '540-546Crossref': [199], '(73)': [202], '2013Chren': [208], 'Linos': [210], 'E.': [211], 'al.Tumor': [215], '5': [217, 1173], 'years': [218], 'cutaneous': [222], 'squamous': [227], 'carcinoma.J': [229], 'Invest': [230, 356, 2018], '2013;': [232, 440, 1327], '133:': [233], '1188-1196Abstract': [234], 'Full': [235, 237, 313, 315, 361, 363, 1939, 1941, 2023, 2025], 'Text': [236, 238, 314, 316, 362, 364, 1940, 1942, 2024, 2026], 'PDF': [239, 317, 365, 1943, 2027], '(132)': [242], 'excision': [245], '(3.5–4.2%),': [246], 'electrodessication': [248], 'curettage': [250], '(1.6–4.9%).': [251], 'Thus,': [252], 'implementation': [254], 'BCCs': [259, 383, 767, 1438, 2114], 'clinical': [262, 2155], 'setting': [263], 'still': [265], 'limited.': [266], 'A': [267, 729, 763], 'high-resolution': [268], 'nuclear-level': [269], 'optical': [270], 'imaging': [271, 489, 495, 590, 625, 1186, 1368, 1744, 2108], 'as': [274, 1278, 1722, 2144], '(RCM;': [278], 'Nori': [279, 1905], '2004Nori': [282, 1908], 'S.': [283, 535, 990, 1877, 1909], 'Rius-Díaz': [284, 1910], 'F.': [285, 1911], 'Cuevas': [286, 1912], 'al.Sensitivity': [289, 1915], 'specificity': [291, 1182, 1917], 'reflectance-mode': [293, 1919], 'vivo': [298, 334, 403, 435, 449, 1230, 1322, 1788, 1868, 1879, 1924, 1960, 1996, 2044], 'diagnosis': [299, 338, 1925, 2000], 'carcinoma:': [303, 432, 1319, 1795, 1929, 2051], 'multicenter': [305, 1931], 'study.J': [306, 437, 1324, 1932], 'Am': [307, 1933], 'Acad': [308, 1934], '2004;': [310, 1936], '51:': [311, 1937], '923-930Abstract': [312, 1938], '(287)': [320, 1946], 'Guitera': [323, 1985], '2012Guitera': [326, 1988], 'P.': [327, 1989], 'Menzies': [328, 1990], 'S.W.': [329, 1991], 'Longo': [330, 1992], 'C.': [331, 418, 1305, 1993], 'al.In': [333, 1787, 1959, 1995, 2043], 'melanoma': [340, 2002], 'using': [345, 693, 786, 1250, 2007], 'two-step': [347, 2009], 'method:': [348, 2010], 'analysis': [349, 2011], '710': [351, 2013], 'consecutive': [352, 887, 909, 1045, 1101, 1156, 2014], 'clinically': [353, 2015], 'equivocal': [354, 2016], 'cases.J': [355, 2017], '132:': [359, 2021], '2386-2394Abstract': [360, 2022], '(246)': [368, 2030], 'Scholar)': [370, 446, 485], 'may': [371, 595, 614, 1084, 1096, 1745, 1816, 2137], 'guide': [372, 423, 1310, 1886, 2116], 'by': [375, 811, 1197, 1892], 'detecting': [376, 1108], 'presence': [378, 1113, 1161, 1208, 1372, 1540, 1602, 1698, 1734], 'or': [379, 1111, 1162, 1718], 'clearance': [380, 1110, 1178, 1190, 1374, 1505, 1570, 1695, 1715], 'residual': [382, 592, 627, 633, 859, 925, 1210, 1376, 1542, 1604, 1845], 'directly': [384, 2131], 'on': [385, 971, 1269, 1753, 1775, 2132], 'patient,': [387], 'provide': [389], 'histopathology-like': [391], 'feedback': [392], 'improve': [394, 1817], 'efficacy.': [396], 'Preliminary': [397], 'studies': [398, 1866, 2156], 'human': [400], 'ex': [402, 434, 1321], 'acetic': [405, 683, 823], 'acid': [406, 684], 'nuclear': [408, 628, 690, 919], 'contrast': [409, 587, 622, 895, 1064, 1835, 1858, 1897], '(Sierra': [410, 1297], '2013Sierra': [413, 1300], 'H.': [414, 460, 1301, 2075], 'Larson': [415, 1302], 'B.A.': [416, 1303], 'Chen': [417, 1304, 2068], 'al.Confocal': [420, 464, 708, 1307, 2079], 'erbium:yttrium': [424, 1311], 'aluminum': [425, 451, 1312, 1893], 'garnet': [426, 1313], 'an': [433, 520, 545, 644, 673, 1000, 1087, 1188, 1320, 1510, 1895], 'feasibility': [436, 487, 1323, 1796, 1968, 2052], 'Biomed': [438, 720, 1325], 'Opt.': [439, 721, 1326], '18:': [441, 1328], '095001Crossref': [442, 1329], '(14)': [444, 1331], 'chloride': [452], '(Chen': [453], '2014Chen': [456, 2071], 'Ch': [457, 2072], 'Sierra': [459, 2074], 'Cordova': [461, 2076], 'carcinoma.JAMA': [476, 2091], '2014;': [478, 2093], '150:': [479, 2094], '994-998Crossref': [480, 2095], '(39)': [483, 2098], 'revealed': [486], 'post-ablated': [491, 1421], 'was': [496, 501, 680, 741, 768, 843, 1027, 1166, 1214, 1343, 1388, 1724], 'quality.': [499], 'Ablation': [500], 'performed': [502, 1028, 1771, 2159], 'pulsed': [505], 'Erbium-doped': [506], 'Yttrium': [507], 'Aluminum': [508], 'Garnet': [509], '(Er:YAG)': [510], 'laser,': [511], 'pulse': [513, 660, 966], 'duration': [514, 967], '∼250': [516], 'μs': [517], 'produces': [519], 'underlying': [521], 'zone': [522, 1661], 'thermal': [524, 553, 576, 597, 942, 972, 1008, 1056, 1659], 'coagulation': [525, 577, 598, 943, 1057, 1660], '∼20': [527], 'μm': [528, 1434], '(Hohenleutner': [529], '1997Hohenleutner': [532, 987], 'U.': [533, 988, 1955], 'Hohenleutner': [534, 984, 989], 'Bäumler': [536, 991], 'W.': [537, 992], 'al.Fast': [539, 994], 'effective': [541, 996], 'laser:': [547, 1002], 'determination': [548, 1003], 'rates': [551, 1006], 'damage': [554, 1009], 'zones.Lasers': [555, 1010], '1997;': [558, 1013], '20:': [559, 1014], '242-247Crossref': [560, 1015], '(156)': [563, 1018], 'We': [566, 594, 1122, 2186], 'therefore': [567], 'hypothesized': [568], 'loss': [570], 'viability': [573], 'due': [574, 937], 'must': [578, 935, 2157], 'affect': [579], 'repeatability': [581], 'consistency': [583], 'uptake': [585, 620, 893, 1062], 'agent': [588, 623, 896, 1065], 'tumor.': [593, 1378, 1507, 1543, 1700], 'control': [596, 1055, 1752], 'optimal': [600, 649], 'choice': [601], 'parameters': [604], '(pulse': [605], 'duration,': [606], 'fluence,': [607], 'number': [608, 652, 797, 910, 946, 1099, 1264], 'pulses,': [610, 809], 'wavelength).': [612], 'This': [613, 934], 'subsequently': [615], 'allow': [616, 1059, 1097], 'repeatable': [617, 890], 'consistent': [619, 892, 1127], 'morphology': [629, 691, 920, 1476], 'detection': [631, 2120], 'BCC': [634, 665, 860, 1377], 'tumors.': [635, 1479, 1846], 'In': [636, 1423, 1878], 'this': [637, 1295, 1852], 'Letter,': [638], 'we': [639, 1053], 'report': [640], 'results': [642, 1741, 1824], 'extended': [645], 'study': [646], 'determining': [648], 'fluence': [650, 873, 881, 1140, 1251, 1293, 1395], 'pulses': [654], 'given': [657], 'wavelength': [658, 779], 'duration.': [661], 'Fifty-eight': [662], 'discarded': [663], 'frozen-thawed': [664], 'specimens': [666, 815, 1023, 1119, 1124, 1234, 1728], 'from': [667, 930, 1351, 2198], 'were': [670, 816, 836, 847, 1070, 1120, 1183, 1239, 1267, 1348], 'obtained': [671], 'under': [672], 'Institutional': [674], 'review': [675], 'board-approved': [676], 'protocol.': [677], 'immersed': [681, 821], '(5%,': [685], '30': [686, 1169], 's)': [687], 'brightening': [689], '(“acetowhitening”)': [692], 'previously': [695, 1285], 'described': [696], 'protocol': [697], '(Patel': [698], '2007Patel': [701], 'Y.G.': [702], 'Nehal': [703], 'K.S.': [704], 'Aranda': [705], 'Y.I.': [706], 'mosaicing': [710], 'surgical': [717], 'excisions.J': [719], '2007;': [722], '12:': [723], '034027Crossref': [724], '(120)': [726], 'microscope': [732], '(Vivascope': [733], '1500,': [734], 'Caliber': [735], 'Imaging': [736], 'Diagnostics,': [738], 'Rochester,': [739], 'NY)': [740], 'used': [742], 'capture': [744], 'mosaics,': [745], 'displaying': [746], 'areas': [747], '8': [749, 752], 'mm': [750], '×': [751, 1172], 'mm,': [753], 'determine': [759], 'regions': [760, 1452], 'containing': [761, 766], 'BCCs.': [762], 'selected': [764, 1123], 'region': [765, 1409, 1517], 'ablated': [769, 840, 1242, 1341, 1359, 1389, 1408], 'our': [771], '(Sciton': [774], 'Profile,': [775], 'Palo': [776], 'Alto,': [777], 'CA;': [778], '2.94': [780], 'μm,': [781, 1642], 'spot': [782], 'diameter': [783], '4': [784], 'mm),': [785], 'fluences': [787], '6.3,': [789], '12.5,': [790], '17.5,': [791], '25.0': [793], 'J': [794, 878, 883, 1143, 1254, 1398, 1975], 'cm−2': [795, 879, 884, 1144, 1255, 1399], 'passes': [799, 912, 948, 1157, 1266], '1–8.': [800], 'Each': [801], 'pass': [802, 1291], 'set': [805], 'four': [807], 'independent': [808], 'separated': [810], '∼40': [812], 'ms.': [813], 'All': [814], 'imaged,': [817], 'ablated,': [818], 'once': [819], 'again': [820], 'acid,': [824], 'then': [825, 1349], 'imaged': [826, 1240], 'finally': [828], 'processed': [829], 'frozen': [831, 1346, 1549], 'histopathology.': [832, 1074, 1176, 1200], 'En': [833], 'face': [834], 'sections': [835, 1347, 1405, 1707], 'prepared': [837, 1350], 'surface': [841, 1342], 'imaged.': [844], 'RCM': [845, 898, 1185, 1337, 1367, 1712, 2107], 'mosaics': [846, 1713], 'qualitatively': [848], 'evaluated': [849, 1167], 'against': [850, 1175], 'corresponding': [852], 'histopathology': [853, 1213, 1404, 1550, 1675, 1706], 'appearance': [856], 'nuclear,': [858], 'tumor,': [861, 1249, 1277], 'dermal': [864, 1501], 'morphology.': [865], 'evaluation': [867], 'showed': [868], 'total': [871, 902, 1147], 'delivered': [872, 904], 'up': [875], '150': [877], '(maximum': [880], '25': [882, 1142, 1253, 1397], '6': [886, 908, 1044, 1078, 1083, 1155, 1401], 'passes)': [888], 'allows': [889], 'imaging.': [899, 1067, 1282], 'For': [900, 1701], 'higher': [901], 'fluences,': [903], 'more': [906, 1098, 1153, 1465], 'than': [907, 1154], 'without': [913], 'any': [914], 'cooling': [916, 1049, 1092], 'in-between,': [917], 'appears': [921, 1838], 'amorphous,': [922], 'tumor': [926, 1115, 1165, 1211, 1572, 1605, 1717, 2122, 2147], 'cannot': [927], 'distinguished': [929], 'dermis.': [933], 'increase': [940], 'increased': [945], '(Walsh': [949], '1989Walsh': [952], 'J.T.': [953], 'Flotte': [954], 'T.J.': [955], 'Anderson': [956], 'al.Er:YAG': [959], 'tissue:': [963], 'effect': [964], 'type': [970], 'damage.Lasers': [973], '1989;': [976], '9:': [977], '314-326Crossref': [978], '(445)': [981], 'which': [1025, 1582, 1613, 1690, 1832], 'time': [1030], 'interval': [1031], 'at': [1033, 1413, 1429, 1555, 1654], 'least': [1034], '1–2': [1035], 's': [1036], 'between': [1037, 1202], 'multiple': [1038], 'treatments': [1039], '(each': [1040], 'consisting': [1041], 'maximum': [1043, 1635], 'passes),': [1046], 'passive': [1048], 'tissue,': [1052], 'subsequent': [1061], 'These': [1068, 1739], 'observations': [1069, 1412, 1710], 'confirmed': [1071, 1410], '(The': [1075], 'limit': [1076], 'warrants': [1079], 'further': [1080, 1691], 'investigation.': [1081], 'Possibly,': [1082], 'not': [1085], 'intrinsic': [1088], 'limit,': [1089], 'active': [1091], 'passes.)': [1102], 'To': [1103, 1227], 'quantify': [1104], 'accuracy': [1106, 1220, 1819, 2164], 'ablation,': [1117, 1335, 1757], '15': [1118], 'selected.': [1121], 'reasonably': [1126], 'initial': [1128, 1740], 'conditions:': [1129], '(a)': [1130], 'contained': [1131], 'large': [1132], 'tumors': [1133], '(b)': [1135], 'treated': [1136], 'highest': [1138], '1–10': [1149], 'passes,': [1150], 'no': [1152], 'per': [1158, 1290], 'treatment.': [1159, 2153], 'absence': [1163], 'half-mosaics': [1170], '(approximately': [1171], 'magnification)': [1174, 1656], 'rate,': [1179], 'sensitivity,': [1180], 'estimated.': [1184], 'found': [1187], 'overall': [1189], '40%': [1193], '23%': [1196], 'inspection': [1198], 'Agreement': [1201], 'assessment': [1205], '77%.': [1215], 'preliminary': [1217], 'measures': [1218], 'are': [1221, 1382], '74%': [1222], 'sensitivity': [1223], '86%': [1225], 'specificity.': [1226], 'mimic': [1228], 'conditions,': [1231], '10': [1232, 1703], 'additional': [1233], 'intact': [1236, 1391], 'stratum': [1237, 1392], 'corneum': [1238], 'intention': [1245], 'completely': [1247], 'clearing': [1248], 'one': [1257], 'treatment,': [1258, 2127], 'each': [1259], '1–6': [1261], 'passes.': [1262, 1402], 'determined': [1268], 'basis': [1271], 'depth': [1274, 1287, 1636, 1755], 'estimated': [1279], 'pre-ablation': [1281, 1427], '(We': [1283], 'have': [1284], 'characterized': [1286], 'Scholar).)': [1333], 'After': [1334], 'mosaic': [1338, 1428], 'captured.': [1344], 'Vertical': [1345, 1403], 'deep': [1355, 1417], 'margins': [1356, 1418, 1769], 'regions.': [1360], 'Figure': [1361, 1424, 1480, 1544, 1564, 1598, 1629, 1666, 1686], '1': [1362, 1736], 'demonstrates': [1363], 'ability': [1365], 'detect': [1370], 'Mosaics': [1379], 'images': [1381], 'shown': [1383], 'specimen': [1386], 'through': [1390, 1406, 1552], 'corneum,': [1393], 'wounds.': [1422], '1a,': [1425], 'dermal–epidermal': [1431], 'junction': [1432], '(∼130': [1433], 'depth)': [1435], 'shows': [1436, 1482, 1499, 1523, 1546], '(region': [1439], 'inside': [1440], 'both': [1441], 'solid': [1442, 1455, 1496, 1594], 'dotted': [1444, 1457], 'yellow': [1445, 1497, 1521, 1595, 1626], 'squares).': [1446], 'Enlarged': [1447], 'views': [1448, 1672], 'two': [1451], 'within': [1453, 1518, 1592, 1623], 'these': [1454], 'squares': [1458], '(Figure': [1459, 1489, 1513], '1b': [1460], 'c,': [1462], 'respectively)': [1463], 'show': [1464, 1670], 'clearly': [1466], 'clusters': [1467, 1524], 'bright': [1469, 1528], 'densely': [1470, 1526], 'distributed': [1471, 1527], 'nuclei': [1472, 1529], '1d': [1481], 'post-ablation': [1484], 'mosaic.': [1485], 'An': [1486], 'enlarged': [1487, 1511], 'view': [1488, 1512], '1e)': [1490], 'area': [1493], 'square': [1498, 1522, 1596, 1627], 'only': [1500], 'collagen': [1502], 'confirms': [1504, 1568], 'By': [1508], 'comparison,': [1509], '1f)': [1514], 'dashed': [1520, 1560, 1589, 1620, 1625, 1682], 'closer': [1530, 1606], 'edge': [1533, 1609], 'wound': [1536, 1578], 'indicates': [1538, 1633, 1657], '1g': [1545], 'vertical': [1548], 'section': [1551, 1567], 'wound,': [1554], 'location': [1557, 1586, 1617, 1679], 'orange': [1561, 1590, 1621, 1683], 'line': [1562, 1591, 1622, 1684], '1d.': [1565], 'center': [1575], '(solid': [1579], 'black': [1580, 1611], 'rectangle,': [1581, 1612], 'corresponds': [1583, 1614], '1d)': [1599], '(dashed': [1610], '1d).': [1630], 'pathology': [1632], '∼160': [1641], 'thin': [1645], 'layer': [1646], 'darker': [1648], 'stained': [1649], 'amorphous': [1650], '(not': [1652, 1770], 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