Title: Inhibition of human platelet aggregation by stable analogs of prostacyclin
Abstract: A novel chemical synthesis of nat- and rac-Prostacyclin (PGI2) and 5,6-dihydro-PGI2 is described. Like PGI2, both stable analogs inhibit human platelet aggregation induced by ADP, Arachidonic Acid (AA), Collagen and Adrenaline. In all forms of aggregation, 5,6α-dihydro-PGI2 resulted 10 times more potent than 5,6β-dihydro-PGI2. The potency ratio of 5,6α-dihydro-PGI2 to PGI2 was variably estimated between 1:100, in the case of ADP-induced aggregation, and 1:10 in the case of AA-induced aggregation. The availability of stable mimics of PGI2 should be of considerable value in future studies of this substance and may have therapeutic implications.
Publication Year: 1977
Publication Date: 1977-11-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 19
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