Title: Naloxone, Beta Endorphins, and High-Altitude Pulmonary Edema
Abstract: Letters and Corrections1 May 1982Naloxone, Beta Endorphins, and High-Altitude Pulmonary EdemaDAVID BAR-OR, M.D., JOHN A. MARX, M.D., JAMES T. GOOD JR., M.D.DAVID BAR-OR, M.D.Search for more papers by this author, JOHN A. MARX, M.D.Search for more papers by this author, JAMES T. GOOD JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-5-684_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: High-altitude pulmonary edema develops in certain unacclimatized and susceptible persons acutely exposed to extreme elevation. Since its original report the clinical manifestations have been well described, but despite numerous speculations the pathogenesis of this disorder remains unclear (1-3).We describe here an otherwise healthy man who presented with high-altitude pulmonary edema, in whom plasma beta endorphins were measured and found to be significantly elevated. Dramatic improvement in the patient's hypoxemia and clinical course occurred after administration of naloxone. We postulate that this opiate antagonist may be beneficial in the treatment of this disorder.A 22-year-old white man,...References1. SINGHKHANNASVIRASTAVALALROYSUBRAMANYAM IKMMSC. Acute mountain sickness. N Engl J Med. 1969;280:175-83. CrossrefMedlineGoogle Scholar2. HULTGRENSPICKARDHELLRIEGELHOUSTON HWHC. High altitude pulmonary edema. Medicine. 1961;40:289-313. CrossrefMedlineGoogle Scholar3. HACKETTRENNIELEVINE PDH. The incidence, importance, and prophylaxis of acute mountain sickness. Lancet. 1976;2:1149-54. CrossrefMedlineGoogle Scholar4. MARTICORENAHULTGREN EH. Evaluation of therapeutic methods in high altitude pulmonary edema. Am J Cardiol. 1979;43:307-12. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: City and County of Denver Department of Health and Hospitals Denver, CO 80204 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEffects of Administration of Intravenous Naloxone on Gas Exchange in Brain-Dead Lung DonorsHigh-altitude pulmonary edema: A collective reviewNaloxone and NaltrexoneArachidonic acid metabolites and endorphinsNaloxone: Effects on hypoxic pulmonary vasoconstrictionThe pulmonary effects of opiate blockade in septic shockNaloxone: New therapeutic rolesThe Anecdotal AntidotesOpioid Peptides in Humans and Their Clinical SignificanceAcute Alveolar EdemaEndogenous opiates: 1982Endogenous Opiates, Pulmonary Edema, and Sleep Apnea SyndromeNaloxone, Itch, Asthma, Urticaria, and AngioedemaSIMON SMITZ, M.D., JEAN-JACQUES LEGROS, M.D., MARC LE MAIRE, PH.D. 1 May 1982Volume 96, Issue 5Page: 684-685KeywordsBlood plasmaEdemaHypoxiaOpiatesPathogenesis Issue Published: 1 May 1982 PDF downloadLoading ...
Publication Year: 1982
Publication Date: 1982-05-01
Language: en
Type: letter
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 16
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