Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1964556827', 'doi': 'https://doi.org/10.2174/1389201003379040', 'title': 'The Chick Embryo Chorioallantoic Membrane as a Model for in vivo Research on Anti-Angiogenesis', 'display_name': 'The Chick Embryo Chorioallantoic Membrane as a Model for in vivo Research on Anti-Angiogenesis', 'publication_year': 2000, 'publication_date': '2000-07-01', 'ids': {'openalex': 'https://openalex.org/W1964556827', 'doi': 'https://doi.org/10.2174/1389201003379040', 'mag': '1964556827', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11467363'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.2174/1389201003379040', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S6052435', 'display_name': 'Current Pharmaceutical Biotechnology', 'issn_l': '1389-2010', 'issn': ['1389-2010', '1873-4316'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320079', 'host_organization_name': 'Bentham Science Publishers', 'host_organization_lineage': ['https://openalex.org/P4310320079'], 'host_organization_lineage_names': ['Bentham Science Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'http://www.mdpi.com/1424-8247/3/3/482/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5107843563', 'display_name': 'Domenico Ribatti', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I5561750', 'display_name': 'University of Bari Aldo Moro', 'ror': 'https://ror.org/027ynra39', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I5561750']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Domenico Ribatti', 'raw_affiliation_strings': ['Institute of Human Anatomy, Histology and Embryology, University of Bari Medical School, Italy.'], 'affiliations': [{'raw_affiliation_string': 'Institute of Human Anatomy, Histology and Embryology, University of Bari Medical School, Italy.', 'institution_ids': ['https://openalex.org/I5561750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012195468', 'display_name': 'Angelo Vacca', 'orcid': 'https://orcid.org/0000-0002-4567-8216'}, 'institutions': [{'id': 'https://openalex.org/I5561750', 'display_name': 'University of Bari Aldo Moro', 'ror': 'https://ror.org/027ynra39', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I5561750']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Angelo Vacca', 'raw_affiliation_strings': ['University Of Bari'], 'affiliations': [{'raw_affiliation_string': 'University Of Bari', 'institution_ids': ['https://openalex.org/I5561750']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000147217', 'display_name': 'Luisa Roncali', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I5561750', 'display_name': 'University of Bari Aldo Moro', 'ror': 'https://ror.org/027ynra39', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I5561750']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Luisa Roncali', 'raw_affiliation_strings': ['University Of Bari'], 'affiliations': [{'raw_affiliation_string': 'University Of Bari', 'institution_ids': ['https://openalex.org/I5561750']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5112176229', 'display_name': 'F Dammacco', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I5561750', 'display_name': 'University of Bari Aldo Moro', 'ror': 'https://ror.org/027ynra39', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I5561750']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Franco Dammacco', 'raw_affiliation_strings': ['University Of Bari'], 'affiliations': [{'raw_affiliation_string': 'University Of Bari', 'institution_ids': ['https://openalex.org/I5561750']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.459, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 124, 'citation_normalized_percentile': {'value': 0.799666, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '1', 'issue': '1', 'first_page': '73', 'last_page': '82'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11131', 'display_name': 'Proteoglycans and glycosaminoglycans research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11131', 'display_name': 'Proteoglycans and glycosaminoglycans research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10602', 'display_name': 'Glycosylation and Glycoproteins Research', 'score': 0.9928, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10422', 'display_name': 'Angiogenesis and VEGF in Cancer', 'score': 0.9253, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/chorioallantoic-membrane', 'display_name': 'Chorioallantoic membrane', 'score': 0.9670299}, {'id': 'https://openalex.org/keywords/in-ovo', 'display_name': 'In ovo', 'score': 0.93426454}, {'id': 'https://openalex.org/keywords/endostatin', 'display_name': 'Endostatin', 'score': 0.6057036}, {'id': 'https://openalex.org/keywords/allantois', 'display_name': 'Allantois', 'score': 0.49941754}], 'concepts': [{'id': 'https://openalex.org/C97230052', 'wikidata': 'https://www.wikidata.org/wiki/Q3854334', 'display_name': 'Chorioallantoic membrane', 'level': 3, 'score': 0.9670299}, {'id': 'https://openalex.org/C2780394083', 'wikidata': 'https://www.wikidata.org/wiki/Q539568', 'display_name': 'Angiogenesis', 'level': 2, 'score': 0.957991}, {'id': 'https://openalex.org/C2778765379', 'wikidata': 'https://www.wikidata.org/wiki/Q17055931', 'display_name': 'In ovo', 'level': 3, 'score': 0.93426454}, {'id': 'https://openalex.org/C207001950', 'wikidata': 'https://www.wikidata.org/wiki/Q141124', 'display_name': 'In vivo', 'level': 2, 'score': 0.7614978}, {'id': 'https://openalex.org/C75920679', 'wikidata': 'https://www.wikidata.org/wiki/Q359012', 'display_name': 'Endostatin', 'level': 3, 'score': 0.6057036}, {'id': 'https://openalex.org/C196843134', 'wikidata': 'https://www.wikidata.org/wiki/Q33196', 'display_name': 'Embryo', 'level': 2, 'score': 0.57010627}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.52418345}, {'id': 'https://openalex.org/C2779207114', 'wikidata': 'https://www.wikidata.org/wiki/Q1364012', 'display_name': 'Allantois', 'level': 3, 'score': 0.49941754}, {'id': 'https://openalex.org/C2777663904', 'wikidata': 'https://www.wikidata.org/wiki/Q988343', 'display_name': 'Blood vessel', 'level': 2, 'score': 0.49088675}, {'id': 'https://openalex.org/C2778271429', 'wikidata': 'https://www.wikidata.org/wiki/Q1281049', 'display_name': 'Neovascularization', 'level': 3, 'score': 0.4846764}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.4674583}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4636449}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.40374663}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.36494797}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.32540897}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.29516485}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.23745331}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.16017365}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.079417974}], 'mesh': [{'descriptor_ui': 'D000481', 'descriptor_name': 'Allantoin', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D002642', 'descriptor_name': 'Chick Embryo', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D002823', 'descriptor_name': 'Chorion', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D009389', 'descriptor_name': 'Neovascularization, Pathologic', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000481', 'descriptor_name': 'Allantoin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002642', 'descriptor_name': 'Chick Embryo', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002823', 'descriptor_name': 'Chorion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008566', 'descriptor_name': 'Membranes', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D008566', 'descriptor_name': 'Membranes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009389', 'descriptor_name': 'Neovascularization, Pathologic', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D009389', 'descriptor_name': 'Neovascularization, Pathologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.2174/1389201003379040', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S6052435', 'display_name': 'Current Pharmaceutical Biotechnology', 'issn_l': '1389-2010', 'issn': ['1389-2010', '1873-4316'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320079', 'host_organization_name': 'Bentham Science Publishers', 'host_organization_lineage': ['https://openalex.org/P4310320079'], 'host_organization_lineage_names': ['Bentham Science Publishers'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.385.618', 'pdf_url': 'http://www.mdpi.com/1424-8247/3/3/482/pdf/', 'source': {'id': 'https://openalex.org/S4306400349', 'display_name': 'CiteSeer X (The Pennsylvania State University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I130769515', 'host_organization_name': 'Pennsylvania State University', 'host_organization_lineage': ['https://openalex.org/I130769515'], 'host_organization_lineage_names': ['Pennsylvania State University'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11467363', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.385.618', 'pdf_url': 'http://www.mdpi.com/1424-8247/3/3/482/pdf/', 'source': {'id': 'https://openalex.org/S4306400349', 'display_name': 'CiteSeer X (The Pennsylvania State University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I130769515', 'host_organization_name': 'Pennsylvania State University', 'host_organization_lineage': ['https://openalex.org/I130769515'], 'host_organization_lineage_names': ['Pennsylvania State University'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'score': 0.75, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 2, 'referenced_works': ['https://openalex.org/W1854803455', 'https://openalex.org/W563632035'], 'related_works': ['https://openalex.org/W70240196', 'https://openalex.org/W3151001638', 'https://openalex.org/W3123712615', 'https://openalex.org/W2394292088', 'https://openalex.org/W2359896480', 'https://openalex.org/W2359165709', 'https://openalex.org/W2348760102', 'https://openalex.org/W2058934794', 'https://openalex.org/W1964556827', 'https://openalex.org/W1572983296'], 'abstract_inverted_index': {'Anti-angiogenesis,': [0], 'i.e.': [1], 'inhibition': [2, 24, 66], 'of': [3, 17, 85, 87, 92], 'blood': [4], 'vessel': [5, 62], 'growth,': [6], 'is': [7, 50, 78], 'being': [8], 'investigated': [9], 'as': [10], 'a': [11], 'way': [12], 'to': [13, 58, 69], 'prevent': [14], 'the': [15, 27, 31, 90], 'growth': [16], 'tumors': [18], 'and': [19, 64], 'other': [20], 'angiogenesis-dependent': [21], 'diseases.': [22], 'Pharmacological': [23], 'interferes': [25], 'with': [26, 34], 'angiogenic': [28], 'cascade': [29], 'or': [30, 36, 41, 72, 76, 81], 'immature': [32], 'neovasculature': [33], 'synthetic': [35], 'semi-synthetic': [37], 'substances,': [38], 'endogenous': [39], 'inhibitors': [40], 'biological': [42], 'antagonists.': [43], 'The': [44, 83], 'chick': [45], 'embryo': [46], 'chorioallantoic': [47], 'membrane': [48, 53], '(CAM)': [49], 'an': [51], 'extraembryonic': [52], 'commonly': [54], 'used': [55], 'in': [56, 67, 89, 100], 'vivo': [57], 'study': [59, 91], 'both': [60], 'new': [61], 'formation': [63], 'its': [65], 'response': [68], 'tissues,': [70], 'cells,': [71], 'soluble': [73], 'factors.': [74], 'Angiogenesis': [75], 'anti-angiogenesis': [77], 'evaluated': [79], 'quantitatively': [80], 'semiquantitatively.': [82], 'fields': [84], 'application': [86], 'CAM': [88], 'anti-angiogenesis,': [93], 'including': [94], 'our': [95], 'personal': [96], 'experience,': [97], 'are': [98], 'illustrated': [99], 'this': [101], 'paper.': [102]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1964556827', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 10}], 'updated_date': '2024-12-24T07:00:19.714135', 'created_date': '2016-06-24'}