Molecular Basis of Vitamin E Action

Name: Work Video:
Duration: 3 min 30 s
Savita Khanna; Sashwati Roy; Hoon Ryu; Praveen M. Bahadduri; Peter W. Swaan; Rajiv R. Ratan; Chandan K. Sen
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2774, 2848, 2902, 2949, 3011, 3096, 3122, 3140, 3164, 3226, 3348, 3447, 3453, 3501, 3582, 3799, 4204, 4297, 4361], 'tocopherols': [7, 234, 461, 528], 'and': [8, 46, 59, 109, 120, 146, 160, 235, 273, 286, 336, 347, 373, 387, 462, 829, 888, 1230, 1611, 1624, 1651, 1654, 1721, 1735, 1810, 1857, 1865, 1878, 1911, 2079, 2309, 2342, 2363, 2393, 2446, 2459, 2480, 2508, 2614, 2659, 2682, 2746, 2795, 2812, 2839, 2861, 2895, 2899, 2997, 3099, 3131, 3154, 3239, 3328, 3370, 3469, 3518, 3609, 3667, 3721, 3759, 3782, 3794, 3803, 3815, 3940, 3942, 3947, 4039, 4041, 4113, 4122, 4174, 4178, 4236, 4338, 4363], 'tocotrienols.': [9, 236], 'This': [10, 55, 237, 282, 1020, 1249, 1304, 2488, 2972, 3232, 3431, 4129], 'work': [11, 238, 1250], 'based': [13, 240, 1252, 3755], 'on': [14, 57, 241, 284, 1253, 1812, 2326, 2375, 2461, 2528, 2818, 2863, 3080, 3273, 3352, 3756, 4098, 4107], 'our': [15, 242, 1254], 'striking': [16, 243, 1255, 1415], 'evidence': [17, 244, 1256, 1347, 1550, 3860], 'that,': [18, 245, 1257, 1349, 3922, 4116], 'in': [19, 71, 135, 149, 246, 298, 362, 376, 605, 634, 1094, 1106, 1258, 1360, 1523, 1565, 1574, 1707, 1728, 1843, 1875, 1881, 1988, 1994, 2007, 2012, 2030, 2063, 2183, 2192, 2194, 2235, 2246, 2259, 2267, 2678, 2733, 3042, 3128, 3160, 3241, 3477, 3590, 3796, 4010, 4024, 4063, 4078, 4133, 4143, 4217, 4253, 4367], 'neuronal': [20, 247, 952, 1024, 1175, 1260, 1577, 2008, 2131, 3918, 4061, 4212], 'cells,': [21, 248, 1261, 2269, 4138], 'nanomolar': [22, 101, 249, 328, 1262, 1560, 3862, 3924, 3962], 'concentrations': [23, 250, 675, 1263, 1561, 2312, 2515, 2691, 3863], 'of': [24, 36, 68, 78, 100, 152, 157, 167, 189, 196, 203, 224, 251, 263, 295, 305, 327, 379, 384, 394, 416, 423, 430, 451, 470, 602, 632, 676, 692, 743, 755, 811, 872, 965, 1002, 1022, 1089, 1264, 1277, 1306, 1313, 1357, 1442, 1445, 1453, 1519, 1562, 1568, 1572, 1677, 1732, 1747, 1754, 1763, 1794, 1818, 1999, 2026, 2041, 2068, 2141, 2233, 2244, 2252, 2291, 2298, 2322, 2471, 2706, 2710, 2760, 2784, 2787, 2803, 2834, 2845, 2855, 2858, 2952, 3074, 3111, 3267, 3294, 3377, 3415, 3486, 3522, 3573, 3614, 3628, 3716, 3744, 3752, 3837, 3864, 3873, 3906, 3911, 3945, 3964, 3971, 4007, 4027, 4037, 4050, 4066, 4136, 4151, 4157, 4162, 4166, 4169, 4183, 4230, 4279, 4310], 'α-tocotrienol,': [25, 102, 252, 329, 1265, 3772, 3912], 'but': [26, 253, 745, 1266, 4001, 4059], 'not': [27, 254, 746, 1267, 3966, 4054], 'α-tocopherol,': [28, 255, 1268], 'block': [29, 256, 1269], 'glutamate-induced': [30, 73, 81, 95, 168, 257, 300, 308, 322, 395, 1270, 1274, 1520, 1554, 1576, 3870, 4057, 4075, 4167], 'death': [31, 258, 863, 953, 1006, 1025, 1271, 1522, 2006, 3871], 'by': [32, 174, 198, 259, 401, 425, 529, 687, 959, 1092, 1272, 1419, 1670, 2085, 2146, 2395, 2491, 2577, 2757, 2781, 3235, 3622, 4034, 4042, 4084, 4176], 'suppressing': [33, 260, 1273], 'early': [34, 261, 1275], 'activation': [35, 262, 1276], 'c-Src': [37, 264, 1278], 'kinase': [38, 265, 1279], '(Sen,': [39, 266], 'C.': [40, 267, 577, 1036], 'K.,': [41, 268], 'Khanna,': [42, 269], 'S.,': [43, 45, 270, 272], 'Roy,': [44, 271], 'Packer,': [47, 274], 'L.': [48, 275, 512, 565, 649, 844, 1132, 1142, 1144, 1165, 1287, 1324, 1374, 1688, 1936, 1952, 1976, 2095, 2119, 2162, 2209, 2916, 3884, 3984], '(2000)': [49, 276], 'J.': [50, 277, 477, 514, 709, 775, 796, 901, 919, 974, 1012, 1039, 1059, 1167, 1184, 1221, 1241, 1288, 1325, 1689, 1774, 1831, 1938, 1953, 2096, 2164, 2211, 2561, 2917, 3025, 3052, 3552, 3659, 3729, 3885, 3985], 'Biol.': [51, 278, 664, 903, 1040, 1200, 1289, 1326, 1389, 1690, 1954, 2097, 2918, 3026, 3886, 3986], 'Chem.': [52, 279, 777, 798, 1041, 1078, 1290, 1327, 1691, 1955, 2098, 2919, 3027, 3887, 3987], '275,': [53, 280], '13049–13055).': [54, 281], 'study': [56, 156, 283, 383, 949, 1343], 'HT4': [58, 285, 1259, 1524, 1667, 2069, 2268, 2301, 3043, 3867, 3955], 'immature': [60, 287, 1210, 3929], 'primary': [61, 141, 288, 368, 1103, 1583, 2130, 3072, 3181, 3265, 3917, 4019, 4080, 4171], 'cortical': [62, 289, 1211, 1584, 3076, 3269, 4172], 'neurons': [63, 84, 103, 119, 142, 290, 311, 330, 346, 369, 993, 1212, 1525, 1585, 1788, 3077, 3270, 3868, 3930, 3956, 4020, 4096, 4121, 4154, 4173, 4192, 4281, 4330], 'suggests': [64, 291], 'central': [66, 293], 'role': [67, 294, 1571], '12-lipoxygenase': [69, 296, 1457], '(12-LOX)': [70, 297], 'executing': [72, 299, 1575], 'neurodegeneration.': [74, 301], 'BL15,': [75, 302], 'an': [76, 303, 1922, 2038, 2182, 2869, 2876, 2934, 3048, 3480, 3519], 'inhibitor': [77, 304, 2618], '12-LOX,': [79, 306, 2707], 'prevented': [80, 307, 4056], 'neurotoxicity.': [82, 309], 'Moreover,': [83, 310], 'isolated': [85, 312, 1742, 1790], 'from': [86, 313, 527, 1449, 1596, 1743, 1791, 1804, 2171, 2188, 2397, 3002, 3287, 3318, 3506, 3869, 4300], '12-LOX-deficient': [87, 314, 1582], 'mice': [88, 315, 1796], 'were': [89, 104, 316, 331, 1594, 1660, 1705, 1741, 1789, 1808, 1841, 1870, 1887, 2035, 2272, 2303, 2313, 2324, 2361, 2373, 2386, 2401, 2457, 2483, 2516, 2526, 2539, 2547, 2575, 2580, 2628, 2640, 2684, 2692, 2769, 2810, 2816, 2905, 3009, 3078, 3090, 3115, 3147, 3173, 3209, 3246, 3255, 3271, 3305, 3310, 3316, 3335, 3382, 3595, 3679, 3806, 3914, 4091, 4186, 4193, 4234, 4291], 'observed': [90, 317, 1309, 1993, 3908, 3921, 4083], 'to': [91, 94, 106, 137, 172, 192, 200, 208, 217, 318, 321, 333, 364, 399, 419, 427, 435, 444, 628, 640, 682, 751, 860, 948, 955, 962, 1028, 1100, 1310, 1423, 1431, 1506, 1559, 1588, 1918, 1996, 2004, 2048, 2134, 2173, 2337, 2452, 2477, 2623, 2765, 2936, 3106, 3289, 3312, 3320, 3363, 3375, 3384, 3445, 3494, 3833, 4093, 4104, 4208, 4340], 'be': [92, 319, 641, 999, 1101, 1311, 1424], 'resistant': [93, 105, 320, 332, 1587], 'death.': [96, 323], 'In': [97, 178, 324, 405, 2218], 'the': [98, 150, 175, 187, 193, 201, 209, 325, 377, 402, 414, 420, 428, 436, 467, 558, 600, 630, 635, 753, 827, 865, 1003, 1345, 1355, 1365, 1433, 1438, 1450, 1456, 1548, 1553, 1569, 1597, 1744, 1784, 1792, 1805, 1900, 1919, 1989, 1997, 2013, 2023, 2049, 2058, 2064, 2139, 2174, 2225, 2260, 2270, 2289, 2292, 2296, 2310, 2357, 2398, 2453, 2481, 2624, 2655, 2679, 2704, 2734, 2753, 2758, 2782, 2808, 2813, 2856, 2859, 2864, 2896, 2940, 2950, 2988, 3003, 3180, 3207, 3300, 3365, 3371, 3378, 3420, 3438, 3507, 3568, 3586, 3598, 3671, 3742, 3776, 3800, 3804, 3824, 3835, 3838, 3841, 3853, 3858, 3903, 3907, 4003, 4028, 4035, 4064, 4079, 4134, 4163, 4218, 4254, 4311, 4368], 'presence': [99, 151, 326, 378], 'glutamate-,': [107, 334], 'homocysteine-,': [108, 335], 'l-buthionine': [110, 337, 1466, 1487, 1608], 'sulfoximine-induced': [111, 338], 'toxicity.': [112, 339], 'Long-term': [113, 340], 'time-lapse': [114, 341, 4043, 4085], 'imaging': [115, 342, 2870, 3281, 3349, 4150, 4278], 'studies': [116, 181, 343, 408, 3678], 'revealed': [117, 162, 344, 389, 3960, 4155], 'that': [118, 163, 183, 345, 390, 410, 689, 820, 988, 1406, 1552, 1581, 3298, 3376, 3861, 3961], 'their': [121, 348, 4123], 'axo-dendritic': [122, 349, 4029, 4124], 'network': [123, 350, 4031, 4125, 4221, 4257], 'are': [124, 351, 690, 869, 1586, 2010, 3475, 3823, 4126, 4365], 'fairly': [125, 352, 4127], 'motile': [126, 353], 'under': [127, 354, 2333, 4117, 4282], 'standard': [128, 355, 3792, 3933, 4099, 4118, 4283], 'culture': [129, 356, 1655, 1813, 1901, 2050, 2262, 3354, 3379, 4100, 4119, 4287], 'conditions.': [130, 357, 4288], 'Such': [131, 358], 'motility': [132, 147, 359, 374], 'was': [133, 360, 1308, 1417, 1903, 1916, 1992, 2028, 2046, 2071, 2144, 2222, 2450, 2475, 2489, 2506, 2621, 2657, 2676, 2719, 2755, 2779, 2828, 2866, 2873, 2982, 3045, 3162, 3233, 3282, 3358, 3395, 3417, 3504, 3575, 3620, 3638, 3647, 3668, 3773, 3787, 3831, 3846, 4082, 4141], 'arrested': [134, 361], 'response': [136, 363, 1995], 'glutamate': [138, 365, 873, 966, 990, 1093, 1589, 2059, 2179, 3103, 3112, 3295, 3326, 3959, 4022, 4069, 4140, 4209, 4231, 4304, 4318, 4346], 'challenge.': [139, 366, 1590], 'Tocotrienol-treated': [140, 367], 'maintained': [143, 370, 1871, 4060], 'healthy': [144, 371, 3331], 'growth': [145, 372, 3332, 4005, 4062], 'even': [148, 375], 'excess': [153, 380], 'glutamate.': [154, 381, 2000, 3107, 3313, 4189, 4249, 4274], 'The': [155, 382, 807, 1087, 1447, 1591, 2032, 2503, 2513, 2671, 2689, 2737, 2777, 3356, 3412, 3451, 3498, 3571, 3617, 3635, 3705, 3769], '12-LOX': [158, 197, 385, 424, 1514, 1555, 1573, 1785, 2266, 2299, 2711, 3416, 3503], 'activity': [159, 386, 469, 754, 1556, 2232, 2239, 2243, 2251, 2258, 2705], 'metabolism': [161, 388], 'this': [164, 391, 1095, 1414], 'key': [165, 392, 1570], 'mediator': [166, 393], 'neurodegeneration': [169, 396], 'subject': [171, 398], 'control': [173, 400, 4153], 'nutrient': [176, 403, 1421], 'α-tocotrienol.': [177, 404], 'silico': [179, 406], 'docking': [180, 407, 3762], 'indicated': [182, 409, 2062, 2732, 3514], 'α-tocotrienol': [184, 218, 411, 445, 633, 1307, 1358, 1399, 1625, 2027, 3093, 3865, 3926, 3965, 4053, 4177, 4197, 4243, 4268, 4333], 'may': [185, 412], 'hinder': [186, 413], 'access': [188, 415], 'arachidonic': [190, 417, 1604, 3948], 'acid': [191, 418, 1601, 1613, 2764, 2799, 2841, 3949], 'catalytic': [194, 421], 'site': [195, 422], 'binding': [199, 426, 3677], 'opening': [202, 429], 'solvent': [205, 432, 2832], 'cavity': [206, 433], 'close': [207, 434], 'active': [210, 437], 'site.': [211, 438], 'These': [212, 439, 3314, 3473], 'findings': [213, 440], 'lend': [214, 441], 'further': [215, 442, 1566], 'support': [216, 443, 1567], 'as': [219, 446, 555, 557, 826, 1029, 1503, 1515, 1628, 1765, 1921, 2061, 2083, 2190, 2549, 2731, 2906, 3479, 3578, 3820, 3848, 3936, 3974, 4032], 'potent': [221, 448, 1401, 1439], 'neuroprotective': [222, 449, 1410, 1440, 3909], 'form': [223, 450, 1021], 'vitamin': [225, 452, 1366], 'E.': [226, 453, 723, 768, 1673, 2555], 'tocotrienols,': [463], 'which': [464, 3461], 'qualitatively': [465], 'exhibit': [466], 'biological': [468], 'α-tocopherol': [471, 679], '(1Brigelius-Flohe': [472], 'R.': [473, 583, 1056, 3652, 3693], 'Traber': [474, 660, 1385], 'M.G.': [475, 495, 510, 661, 1386], 'FASEB': [476, 973, 1220, 1773, 1830], '1999;': [478], '13:': [479, 1244], '1145-1155Crossref': [480], 'PubMed': [481, 504, 520, 571, 590, 621, 669, 715, 736, 781, 802, 849, 907, 924, 942, 978, 1017, 1050, 1064, 1082, 1122, 1149, 1189, 1205, 1225, 1246, 1299, 1336, 1394, 1541, 1700, 1778, 1835, 1964, 1981, 2107, 2124, 2566, 2928, 2967, 3036, 3064, 3557, 3735, 3896, 3996], 'Scopus': [482, 505, 521, 572, 591, 622, 670, 716, 737, 782, 803, 850, 908, 943, 979, 1051, 1065, 1083, 1123, 1150, 1190, 1206, 1226, 1300, 1337, 1395, 1542, 1701, 1779, 1836, 1965, 1982, 2108, 2125, 2929, 2968, 3037, 3065, 3558, 3736, 3897, 3997], '(1237)': [483], 'Google': [484, 507, 523, 574, 593, 624, 672, 718, 739, 784, 805, 852, 886, 910, 925, 945, 981, 1018, 1053, 1067, 1085, 1125, 1152, 1172, 1192, 1208, 1228, 1247, 1302, 1339, 1397, 1544, 1703, 1781, 1838, 1943, 1967, 1984, 2110, 2127, 2169, 2216, 2567, 2931, 2970, 3039, 3067, 3560, 3665, 3738, 3899, 3999], 'Scholar).': [485, 524, 594, 625, 673, 740, 806, 853, 911, 982, 1019, 1086, 1248, 1303, 1340, 1782, 1839, 1985, 2128, 2217, 2568, 2932, 2971, 3040, 3068, 3711, 3739, 3900], 'Compared': [486], 'with': [487, 552, 1364, 1713, 1848, 1895, 1905, 1909, 2037, 2275, 2344, 2365, 2388, 2571, 2727, 2886, 2977, 3084, 3092, 3102, 3119, 3133, 3152, 3179, 3200, 3211, 3277, 3284, 3360, 3404, 3483, 3492, 3524, 3567, 3602, 3670, 3932, 3954, 3958, 4021, 4052, 4188, 4195, 4332], 'tocopherols,': [488], 'tocotrienols': [489, 542], 'have': [490, 748, 821], 'been': [491, 638, 749, 986, 1098], 'poorly': [492], 'studied': [493], '(2Traber': [494], 'Sies': [496], 'H.': [497, 1138, 1180], 'Annu.': [498], 'Rev.': [499, 882], 'Nutr.': [500, 516, 711], '1996;': [501, 3732], '16:': [502], '321-347Crossref': [503], '(432)': [506], 'Scholar,': [508, 575, 719, 785, 926, 1054, 1068, 1126, 1153, 1193, 1944, 1968, 2111], '3Traber': [509], 'Packer': [511, 564, 648, 843, 1143, 1164, 1286, 1323, 1373, 1687, 1935, 1951, 1975, 2094, 2118, 2161, 2208, 2915, 3883, 3983], 'Am.': [513, 708, 1166, 1937, 2163, 2210, 2560], 'Clin.': [515, 710], '1995;': [517, 618, 712], '62:': [518, 713], '1501S-1509SCrossref': [519], '(308)': [522], 'Tocotrienols': [525], 'differ': [526], 'possessing': [530], 'farnesyl': [532], '(isoprenoid)': [533], 'rather': [534], 'than': [535, 1354], 'saturated': [537, 822], 'phytyl': [538], 'side': [539, 809], 'chain.': [540], 'Dietary': [541], 'become': [543], 'incorporated': [544], 'into': [545, 818, 3641], 'circulating': [546], 'human': [547, 1361, 1427, 1631], 'lipoproteins,': [548], 'where': [549, 4139], 'they': [550], 'react': [551], 'peroxyl': [553], 'radicals': [554], 'efficiently': [556], 'corresponding': [559], 'tocopherol': [560], 'isomers': [561], '(4Serbinova': [562], 'E.A.': [563], 'Methods': [566, 2962], 'Enzymol.': [567, 2963], '1994;': [568, 733, 778], '234:': [569], '354-366Crossref': [570], '(194)': [573], '5Suarna': [576], 'Hood': [578], 'R.L.': [579, 970, 1217, 1770, 1827], 'Dean': [580], 'R.T.': [581], 'Stocker': [582], 'Biochim.': [584, 730], 'Biophys.': [585, 731], 'Acta.': [586, 732], '1993;': [587, 846, 1243, 3662], '1166:': [588], '163-170Crossref': [589], '(151)': [592], 'Indeed,': [595], 'tocotrienol': [596, 812, 2701, 2730], 'supplementation': [597, 627], 'beneficially': [598], 'influences': [599], 'course': [601], 'carotid': [603], 'atherosclerosis': [604], 'humans': [606], '(6Tomeo': [607], 'A.C.': [608], 'Geller': [609], 'M.': [610, 834, 2957, 3550], 'Watkins': [611], 'T.R.': [612], 'Gapor': [613], 'A.': [614, 697, 707, 729, 1234, 2559], 'Bierenbaum': [615], 'M.L.': [616], 'Lipids.': [617], '30:': [619], '1179-1183Crossref': [620], '(127)': [623, 717, 783], 'Following': [626], 'humans,': [629], 'level': [631, 2297], 'plasma': [636, 1362], 'has': [637, 985, 1097, 1400, 1512], 'estimated': [639], '1': [642, 2425, 2433, 2436, 2606, 2615, 2666, 2747, 2796, 3165], 'μm': [643, 1855, 2611, 2616, 2762], "(7O'Byrne": [644, 1369], 'D.': [645, 699, 701, 900, 916, 918, 932, 1009, 1011, 1058, 1072, 1128, 1155, 1182, 1370, 1531, 1672, 1926, 2152, 2199], 'Grundy': [646, 1371], 'S.': [647, 651, 892, 1070, 1111, 1136, 1159, 1283, 1285, 1320, 1322, 1372, 1376, 1684, 1686, 1930, 1948, 1950, 1974, 2091, 2093, 2117, 2156, 2203, 2912, 2914, 2955, 2959, 3016, 3024, 3054, 3880, 3882, 3980, 3982], 'Devaraj': [650, 1375], 'Baldenius': [652, 1377], 'K.': [653, 657, 772, 1034, 1113, 1115, 1378, 1382], 'Hoppe': [654, 1379], 'P.P.': [655, 1380], 'Kraemer': [656, 1381], 'Jialal': [658, 1383], 'I.': [659, 1384], 'Free': [662, 1198, 1387], 'Radic.': [663, 1199, 1388], 'Med.': [665, 776, 797, 1077, 1201, 1390], '2000;': [666, 1291, 1328, 1391, 1692, 1956, 1978, 2099, 2121, 2920, 3061, 3888, 3988], '29:': [667, 1392], '834-845Crossref': [668, 1393], '(112)': [671, 1396], 'At': [674], '25–50': [677], 'μm,': [678], 'known': [681, 1422], 'regulate': [683], 'signal': [684, 1402], 'transduction': [685, 1403], 'pathways': [686], 'mechanisms': [688, 1435], 'independent': [691, 1312, 3872], 'its': [693, 1314, 1409, 3874], 'antioxidant': [694, 1315, 3875], 'properties': [695, 1405, 3474], '(8Azzi': [696], 'Boscoboinik': [698], 'Marilley': [700], 'Ozer': [702], 'N.K.': [703], 'Stauble': [704, 726], 'B.': [705, 727], 'Tasinato': [706], '1337S-1346SCrossref': [714], '9Boscoboinik': [720], 'D.O.': [721], 'Chatelain': [722], 'Bartoli': [724], 'G.M.': [725, 3687, 3726], 'Azzi': [728], '1224:': [734], '418-426Crossref': [735], '(30)': [738], 'Micromolar': [741], 'amounts': [742, 1351, 1444], 'tocotrienol,': [744], 'tocopherol,': [747], 'shown': [750, 3819], 'suppress': [752], 'hydroxy-3-methylglutaryl-coenzyme': [756], 'A': [757, 3511], 'reductase': [758], '(10Pearce': [759], 'B.C.': [760, 787], 'Parker': [761, 788], 'R.A.': [762, 789], 'Deason': [763, 790], 'M.E.': [764, 791], 'Dischino': [765], 'D.D.': [766], 'Gillespie': [767], 'Qureshi': [769, 792], 'A.A.': [770, 793], 'Volk': [771], 'Wright': [773, 794], 'J.J.': [774, 795, 1240], '37:': [779], '526-541Crossref': [780], '11Pearce': [786], '1992;': [799, 1119, 2563], '35:': [800], '3595-3606Crossref': [801], '(247)': [804], 'unsaturated': [808], 'chain': [810], 'allows': [813], 'more': [815], 'efficient': [816], 'penetration': [817], 'tissues': [819], 'fatty': [823], 'layers': [824], 'such': [825, 3935], 'brain': [828], 'liver': [830], '(12Suzuki': [831], 'Y.J.': [832], 'Tsuchiya': [833], 'Wassall': [835], 'S.R.': [836], 'Choo': [837], 'Y.M.': [838], 'Govil': [839], 'G.': [840, 1130], 'Kagan': [841], 'V.E.': [842], 'Biochemistry.': [845], '32:': [847], '10692-10699Crossref': [848], '(304)': [851, 1151], 'Glutamate': [854, 1913], 'toxicity': [855, 890, 991], 'major': [858, 1510], 'contributor': [859], 'pathological': [861], 'cell': [862, 1005, 1521, 1663, 2220, 2261, 2454, 2625, 3089, 3263, 3280, 3972, 4014, 4277], 'within': [864], 'nervous': [866], 'system.': [867], 'There': [868], 'two': [870], 'forms': [871], 'toxicity:': [874], 'receptor-initiated': [875], 'excitotoxicity': [876], '(13Choi': [877], 'D.W.': [878], 'Cerebrovasc.': [879], 'Brain': [880], 'Metab.': [881], '1990;': [883, 975, 1222, 1775, 1832], '2:': [884], '105-147PubMed': [885], 'Scholar)': [887, 946, 1704, 2170, 3666], 'nonreceptor-mediated': [889], '(14Tan': [891], 'Sagara': [893], 'Y.': [894, 896, 928, 1032, 1527, 3058], 'Liu': [895], 'Maher': [897, 929, 1037, 1073, 1528], 'P.': [898, 930, 1038, 1074, 1178, 1529], 'Schubert': [899, 931, 1057, 1071, 1530], 'Cell': [902], '1998;': [904], '141:': [905], '1423-1432Crossref': [906], '(643)': [909], 'One': [912], 'established': [913], 'model': [914, 1096, 3393, 3414, 3583, 3802], '(15Schubert': [915, 1008], 'Piasecki': [917, 1010], 'Neurosci.': [920, 1013, 1242], '2001;': [921, 1014, 1079], '21:': [922, 1015], '7455-7462Crossref': [923, 1016], '16Li': [927], 'Neuron.': [933, 1532], '1997;': [934, 1146, 1169, 1186, 1202, 1533, 1940, 2166, 2213], '19:': [935, 1534], '453-463Abstract': [936, 1535], 'Full': [937, 939, 1045, 1047, 1294, 1296, 1331, 1333, 1536, 1538, 1695, 1697, 1959, 1961, 2102, 2104, 2923, 2925, 3031, 3033, 3891, 3893, 3991, 3993], 'Text': [938, 940, 1046, 1048, 1295, 1297, 1332, 1334, 1537, 1539, 1696, 1698, 1960, 1962, 2103, 2105, 2924, 2926, 3032, 3034, 3892, 3894, 3992, 3994], 'PDF': [941, 1049, 1298, 1335, 1540, 1699, 1963, 2106, 2927, 3035, 3895, 3995], '(420)': [944, 1543], 'used': [947, 1461, 1482, 1661, 2003, 2901, 3010, 3576, 3832], 'oxidative': [950, 989, 1090], 'stress-related': [951], 'inhibit': [956], 'cystine': [957], 'uptake': [958], 'exposing': [960], 'cells': [961, 1109, 1176, 1213, 1232, 1668, 1807, 2009, 2070, 2143, 2172, 2234, 2245, 2254, 2271, 2302, 2383, 2536, 2574, 3044, 3114, 3286, 3309, 3315, 3350, 4009, 4051, 4185, 4233], 'high': [963, 1474, 1495], 'levels': [964, 1356, 3963], '(17Murphy': [967, 1214, 1767, 1824], 'T.H.': [968, 1215, 1768, 1825], 'Schnaar': [969, 1216, 1769, 1826], 'Coyle': [971, 1218, 1771, 1828], 'J.T.': [972, 1219, 1772, 1829], '4:': [976, 1223, 1776, 1833], '1624-1633Crossref': [977, 1224, 1777, 1834], '(386)': [980, 1227, 1780, 1837], 'Recently,': [983], 'it': [984], 'validated': [987], 'toward': [992], 'lacking': [994], 'functional': [995], 'N-methyl-d-aspartate': [996], 'receptors': [997], 'can': [998], 'component': [1001], 'excitotoxicity-initiated': [1004], 'pathway': [1007, 1502], 'inducible': [1023], 'referred': [1027], 'oxytosis': [1030], '(18Sagara': [1031], 'Ishige': [1033], 'Tsai': [1035], '2002;': [1042, 1061, 2964, 3028], '277:': [1043, 3029], '36204-36215Abstract': [1044], '(76)': [1052], '19Dargusch': [1055], 'Neurochem.': [1060], '81:': [1062], '1394-1400Crossref': [1063], '(41)': [1066], '20Tan': [1069], 'Curr.': [1075], 'Top.': [1076], '1:': [1080], '497-506Crossref': [1081], '(368)': [1084], 'induction': [1088], 'stress': [1091], 'demonstrated': [1099, 3329], 'cytotoxic': [1104], 'mechanism': [1105], 'C6': [1107], 'glial': [1108], '(21Kato': [1110], 'Negishi': [1112], 'Mawatari': [1114], 'Kuo': [1116], 'C.H.': [1117], 'Neuroscience.': [1118, 1977, 2120], '48:': [1120], '903-914Crossref': [1121], '(122)': [1124], '22Han': [1127], 'Handelman': [1129], 'Marcocci': [1131], 'Sen': [1133, 1156, 1927, 1971, 2114, 2153, 2200, 2960], 'C.K.': [1134, 1157, 1281, 1318, 1682, 1928, 1946, 1972, 2089, 2115, 2154, 2201, 2910, 2961, 3014, 3878, 3978], 'Roy': [1135, 1158, 1284, 1321, 1685, 1929, 1949, 1973, 2092, 2116, 2155, 2202, 2913, 3023, 3881, 3981], 'Kobuchi': [1137], 'Tritschler': [1139, 1162, 1933, 2159, 2206], 'H.J.': [1140, 1163, 1934, 2160, 2207], 'Flohe': [1141], 'Biofactors.': [1145], '6:': [1147], '321-338Crossref': [1148], '23Han': [1154], 'Kobayashi': [1160, 1931, 2157, 2204], 'M.S.': [1161, 1932, 2158, 2205], 'Physiol.': [1168, 1939, 2165, 2212, 2562], '273:': [1170, 1941, 2167, 2214], 'R1771-R1778PubMed': [1171, 1942, 2168, 2215], 'Scholar),': [1173, 1209, 1229, 1398, 1545, 3561, 4000], 'PC-12': [1174], '(24Froissard': [1177], 'Monrocq': [1179], 'Duval': [1181], 'Eur.': [1183, 3551], 'Pharmacol.': [1185], '326:': [1187], '93-99Crossref': [1188], '(78)': [1191], '25Pereira': [1194], 'C.M.': [1195], 'Oliveira': [1196], 'C.R.': [1197], '23:': [1203], '637-647Crossref': [1204], '(109)': [1207], 'oligodendoglial': [1231], '(26Oka': [1233], 'Belliveau': [1235], 'M.J.': [1236], 'Rosenberg': [1237], 'P.A.': [1238], 'Volpe': [1239], '1441-1453Crossref': [1245], '(27Sen': [1280, 1317, 1681, 2088, 2909, 3877, 3977], 'Khanna': [1282, 1319, 1683, 1947, 2090, 2911, 2958, 3015, 3879, 3979], '275:': [1292, 1329, 1693, 1957, 2100, 2921, 3889, 3989], '13049-13055Abstract': [1293, 1330, 1694, 1958, 2101, 2922, 3890, 3990], '(270)': [1301, 1338, 1702, 1966, 2109, 2930, 3898, 3998], 'function': [1305, 3606, 4015], 'property': [1316, 1416, 1441, 3876], 'Our': [1341], 'previous': [1342, 2196], 'presented': [1344], 'first': [1346, 1549, 3859], 'showing': [1348], 'at': [1350, 1725, 1815, 1872, 2403, 2410, 2493, 2500, 2510, 2582, 2588, 2636, 2643, 2650, 2661, 2668, 2686, 2721, 2771, 2800, 2842, 2851, 2984, 2987, 3006, 3125, 3143, 3167, 3176, 3229, 3367, 3443, 3923], '4–10-fold': [1352], 'lower': [1353], 'detected': [1359, 2874, 2983, 3046], 'supplemented': [1363, 1712, 1847, 1908], 'molecule': [1368, 3771, 3813, 3816], 'regulatory': [1404], 'account': [1407], 'function.': [1411], 'Of': [1412], 'importance,': [1413], 'exhibited': [1418], 'safe': [1425], 'consumption.': [1428], 'We': [1429, 3920, 4090], 'sought': [1430], 'characterize': [1432], 'molecular': [1434, 3757], 'responsible': [1436], 'trace': [1443], 'tocotrienol.': [1446, 1507, 1563], 'results': [1448], 'current': [1451, 2941], 'line': [1452], 'investigation': [1454], 'identified': [1455, 1513], '(LOX)': [1458], '1The': [1459], 'abbreviations': [1460, 1481], 'are:': [1462, 1483], 'LOX,': [1463, 1484], 'lipoxygenase;': [1464, 1485], 'BSO,': [1465, 1486], '(S,R)-sulfoximine;': [1467, 1488], 'BisTris,': [1468, 1489], '2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol;': [1469, 1490], 'PBS,': [1470, 1491, 2573, 3120], 'phosphate-buffered': [1471, 1492, 2390], 'saline;': [1472, 1493], 'HPLC,': [1473, 1494], 'performance': [1475, 1496], 'liquid': [1476, 1497], 'chromatography;': [1477, 1498], '12-HETE,': [1478, 1499], '12-hydroxyeicosatetraenoic': [1479, 1500], 'acid.1The': [1480], 'acid.': [1501], 'being': [1504], 'sensitive': [1505, 1558], 'Although': [1508], 'publication': [1511], 'critical': [1517], 'facilitator': [1518], '(16Li': [1526], 'we': [1546, 1579, 3856], 'present': [1547], 'demonstrating': [1551], 'Additionally,': [1564], 'death,': [1578], 'show': [1580], 'following': [1592, 2226, 2288, 2989], 'materials': [1593], 'obtained': [1595], 'sources': [1598], 'indicated:': [1599], 'l-glutamic': [1600], 'monosodium': [1602], 'salt,': [1603], 'acid,': [1605, 3939], 'dimethyl': [1606], 'sulfoxide,': [1607], '(S,R)-sulfoximine': [1609], '(BSO),': [1610], 'l-homocysteic': [1612, 3938], '(Sigma);': [1614], 'baicalein': [1615], '(5,6,7-trihydroxyflavone,': [1616], 'BL15)': [1617], '(Oxford': [1618], 'Biomedical': [1619], 'Research,': [1620, 3707], 'Inc.,': [1621, 2351, 2890], 'Oxford,': [1622], 'MI);': [1623], '(commercially': [1626], 'available': [1627], 'Tocomin™': [1629], 'dietary': [1632], 'supplementation)': [1633], '(Carotech,': [1634], 'Ipoh,': [1635], 'Malaysia;': [1636], 'BASF,': [1637], 'Ludwigshafen,': [1638], 'Germany).': [1639], "Dulbecco's": [1640, 1708], 'modified': [1641, 1709], "Eagle's": [1642, 1710], 'medium,': [1643, 1646], 'minimal': [1644, 1844], 'essential': [1645, 1845], 'fetal': [1647, 1715, 1851], 'calf': [1648, 1716], 'serum,': [1649, 1717, 1853], 'penicillin,': [1650, 1720, 1864], 'streptomycin': [1652, 1724], '(Invitrogen)': [1653, 2332], 'dishes': [1656, 2051], '(Nunc,': [1657], 'Roskilde,': [1658], 'Denmark)': [1659], 'culture.': [1664], 'Mouse': [1665], 'hippocampal': [1666], '(provided': [1669], 'Dr.': [1671], 'Koshland,': [1674], 'Jr.,': [1675, 3539], 'University': [1676], 'California,': [1678], 'Berkeley,': [1679, 3196], 'CA)': [1680], 'grown': [1706, 1842], 'medium': [1711, 1846, 1902, 1907, 1920, 1990, 2175], '10%': [1714, 1849, 2472], '100': [1718, 1722, 1862, 2610], 'units/ml': [1719, 1863], 'μg/ml': [1723, 1860, 1867, 2441, 2444, 2448], '37': [1726, 1873, 2772, 3368], '°C': [1727, 1874, 2773, 3178, 3369], 'humidified': [1730, 1883], 'atmosphere': [1731], '95%': [1733, 1879], 'air': [1734, 1880], '5%': [1736, 1876, 2431], 'CO2.': [1737], 'Primary': [1738], 'Cortical': [1739], 'Neurons—Cells': [1740], 'cerebral': [1745], 'cortex': [1746], 'rat': [1748, 3075, 3268, 4170], 'fetuses': [1749, 1758, 1793], '(Sprague-Dawley': [1750], 'rats,': [1751], 'day': [1752, 1761], '17': [1753], 'gestation)': [1755, 1764], 'or': [1756, 2056, 2280, 2728, 3094, 3104, 3188, 3217, 4200], 'mouse': [1757], '(C57BL/6': [1759], 'mice,': [1760], '14': [1762], 'described': [1766, 2011, 2084, 2191, 2550, 2908], 'For': [1783, 3069, 3261], 'knockout': [1786], 'studies,': [1787], 'B6.129S2-Alox15tm1Fun': [1795], '(Jackson': [1797], 'Laboratory,': [1798], 'Bar': [1799], 'Harbor,': [1800], 'ME).': [1801], 'After': [1802, 2380, 2466, 2533, 2569, 2653, 2750, 2806, 3086, 3108, 3170, 3198, 4180, 4227], 'isolation': [1803], 'brain,': [1806], 'counted': [1809], 'seeded': [1811, 2374, 2527], 'plates': [1814, 3082, 3275, 4101], 'density': [1817], '2–3': [1819], '×': [1820, 2371, 2377, 2405, 2495, 2524, 2530, 2645, 2663], '106': [1821], 'cells/35-mm': [1822], 'plate': [1823, 2865], 'Cells': [1840, 2369, 2522], 'heat-inactivated': [1850], 'bovine': [1852, 3157], '40': [1854], 'cystine,': [1856], 'antibiotics': [1858], '(100': [1859], 'streptomycin,': [1861], '0.25': [1866], 'amphotericin).': [1868], 'Cultures': [1869], 'CO2': [1877], 'incubator.': [1884, 3380], 'All': [1885], 'experiments': [1886, 3913], 'carried': [1888, 3396, 3680, 3789], 'out': [1889, 3397, 3681, 3790], '24': [1890, 2176, 2305, 3087, 3109, 4181, 4228], 'h': [1891, 2177, 2306, 2667, 3110, 3166, 3291, 3322, 4182, 4229, 4299, 4302, 4316, 4344], 'after': [1892, 2057, 2178, 2307, 3325, 3631, 4303, 4317, 4345], 'plating.': [1893], 'Treatment': [1894], 'Neurotoxic': [1896], 'Agents—Immediately': [1897], 'before': [1898, 2055, 4160], 'experiments,': [1899], 'replaced': [1904], 'fresh': [1906], 'serum': [1910, 3158], 'antibiotics.': [1912], '(10': [1914, 2592], 'mm)': [1915], 'added': [1917, 2047, 2451, 2476, 2622], 'aqueous': [1923, 3242], 'solution': [1924, 2790], '(23Han': [1925, 2151, 2198], '27Sen': [1945], '28Tirosh': [1969, 2112], 'O.': [1970, 2113, 3546], '97:': [1979, 2122], '531-541Crossref': [1980, 2123], '(74)': [1983, 2126], 'No': [1986], 'change': [1987], 'pH': [1991], 'addition': [1998, 2759, 2783], 'Other': [2001], 'agents': [2002], 'induce': [2005], 'pertinent': [2014], 'figure': [2015, 2065, 2735], 'legends.': [2016, 2066, 2736], 'Treatment—Stock': [2019], 'solutions': [2020], '(103': [2021], 'times': [2022, 3118, 3151], 'working': [2024], 'concentration)': [2025], 'prepared': [2029, 2548], 'ethanol.': [2031], 'respective': [2033], 'controls': [2034], 'treated': [2036, 3091], 'equal': [2039], 'volume': [2040], 'ethanol': [2042], '(0.1%,': [2043], 'v/v).': [2044], 'α-Tocotrienol': [2045], 'either': [2052, 4196], '5': [2053, 2408, 2440, 2443, 2447, 3097, 3204, 4205], 'min': [2054, 2409, 2499, 2587, 2649, 2726, 2850, 3098, 3124, 3142, 3205, 3228, 3340, 4206, 4296], 'treatment': [2060, 2180, 3327], 'Viability': [2067], 'determined': [2072, 2223, 2314, 2517, 2693], 'using': [2073, 2181, 2224, 2282, 2315, 2518, 2630, 2694, 2830, 2868, 2875, 3047, 3248, 3257, 3341, 3388, 3398, 3419, 3585, 3597, 3649, 3682, 3764, 3775, 3791, 3808, 3916], 'propidium': [2075], 'iodide': [2076], 'exclusion': [2077], 'assay': [2078, 2186, 2904], 'flow': [2081, 2137], 'cytometer': [2082], 'us': [2086], 'previously': [2087, 2551, 2907, 2937], 'Because': [2129], 'cultures': [2132, 3073, 3266], 'tend': [2133], 'aggregate': [2135], 'during': [2136], 'cytometry,': [2138], 'viability': [2140, 2221, 2228, 3973], 'these': [2142, 4008], 'assessed': [2145], 'measuring': [2147], 'lactate': [2148, 2230, 2237, 2241, 2249, 2256], 'dehydrogenase': [2149, 2231, 2238, 2242, 2250, 2257], 'leakage': [2150], 'vitro': [2184], 'toxicology': [2185], 'kit': [2187], 'Sigma': [2189], 'detail': [2193], 'report': [2197], 'brief,': [2219], 'equation:': [2227], '=': [2229], 'monolayer/total': [2236], '(i.e.': [2240], 'monolayer': [2247], '+': [2248, 2255, 4244, 4248, 4269, 4273], 'detached': [2253], 'medium).': [2263], 'To': [2264, 2294, 2355, 2698, 3901], 'overexpress': [2265], 'transiently': [2273], 'transfected': [2274], 'plasmid': [2276], 'pcDNA3.1+12-LOX': [2277], '(ResGen,': [2278], 'Invitrogen)': [2279], 'pcDNA3.1': [2281], 'FuGENE': [2283], '6': [2284], '(Roche': [2285], 'Applied': [2286], 'Science)': [2287], 'instructions': [2290], 'manufacturer.': [2293], 'assess': [2295], 'expression,': [2300], 'harvested': [2304, 2394, 2540, 2576], 'transfection,': [2308], 'protein': [2311, 2317, 2514, 2520, 2690, 2696, 3449, 3581, 3673], 'BCA': [2316, 2519, 2695], 'reagents.': [2318, 2521, 2697], 'Samples': [2319, 2400, 2456, 2579, 2627, 2639, 2768, 3146], '(20': [2320], 'μg': [2321], 'protein/lane)': [2323], 'separated': [2325], 'NuPAGE™': [2328], '4–12%': [2329], 'BisTris': [2330], 'gel': [2331, 2821], 'reducing': [2334], 'conditions,': [2335, 4120], 'transferred': [2336], 'polyvinylidene': [2339], 'difluoride': [2340], 'membrane,': [2341], 'probed': [2343], 'anti-12-LOX': [2345], 'polyclonal': [2346], 'antiserum': [2347], '(Cayman': [2348], 'Chemical': [2349], 'Co.,': [2350], 'Ann': [2352], 'Arbor,': [2353], 'MI).': [2354], 'evaluate': [2356], 'loading': [2358], 'efficiency,': [2359], 'membranes': [2360, 2546], 'stripped': [2362], 'reprobed': [2364], 'anti-β-actin': [2366], 'antibody': [2367, 3182, 3220], '(Sigma).': [2368], '(1.7': [2370, 2523], '106)': [2372, 2525], '140': [2376, 2529], '20-mm': [2378, 2531], 'plates.': [2379, 2532, 3355], '12–18': [2381, 2534], 'h,': [2382, 2535, 3088, 4271], '(two': [2384], 'plates/sample)': [2385, 2538], 'washed': [2387, 3116], 'ice-cold': [2389, 2572, 2788], 'saline': [2391], '(PBS)': [2392], 'scraping': [2396], 'dishes.': [2399], 'spun': [2402, 2581, 2642, 2660], '700': [2404, 2583, 2995], 'g': [2406, 2496, 2646, 2664], '4': [2411, 2501, 2589, 2637, 2651, 2669, 3177], '°C.': [2412, 2502, 2512, 2590, 2638, 2652, 2670, 2688, 2853], 'Buffer': [2413, 2591], '(400': [2414], 'μl)': [2415], 'containing': [2416, 2594, 2791, 3136], '10': [2417, 2422, 2586, 2708, 3123, 4067], 'mm': [2418, 2423, 2426, 2429, 2434, 2437, 2596, 2601, 2604, 2607, 2742, 2748, 4068], 'HEPES': [2419], '(pH': [2420, 2598, 2744], '7.8),': [2421], 'KCl,': [2424], 'Na2EDTA,': [2427], '2': [2428, 2603], 'MgCl2,': [2430], 'glycerol,': [2432], 'dithiothreitol,': [2435], 'phenylmethylsulfonyl': [2438, 2612], 'fluoride,': [2439, 2613], 'leupeptin,': [2442], 'aprotinin,': [2445], 'antipain': [2449], 'pellet.': [2455, 2626], 'resuspended': [2458, 2677], 'kept': [2460, 2509, 2770], 'ice': [2462], '15': [2464, 2467, 2725, 2751, 3339, 4295], 'min.': [2465, 2776], 'min,': [2468, 2752], '30': [2469, 2486, 2775, 4349], 'μl': [2470, 2786], 'Nonidet': [2473], 'P-40': [2474], 'each': [2478, 2766], 'sample,': [2479], 'samples': [2482, 2683, 2809, 3172, 3208], 'vortexed': [2484], 's.': [2487], 'followed': [2490, 3234], 'centrifugation': [2492], '14,000': [2494], '20': [2498, 2595, 3141], 'cystolic': [2504], 'supernatant': [2505, 2656], 'collected': [2507, 2658, 3247, 3336, 4292], '–80': [2511, 2687], '(five': [2537], 'total': [2542, 2673], 'membrane': [2543, 2674], 'preparation.': [2544], 'Total': [2545], '(29Bashan': [2552], 'N.': [2553], 'Burdett': [2554], 'Hundal': [2556], 'H.S.': [2557], 'Klip': [2558], '262:': [2564], 'C682-C690Crossref': [2565], 'washing': [2570, 3199], 'scraping.': [2578], '×g': [2584], 'ml)': [2593], 'NaHEPES': [2597], '7.4),': [2599], '250': [2600], 'sucrose,': [2602], 'EGTA,': [2605], 'sodium': [2608], 'azide,': [2609], 'protease': [2617], 'mixture': [2619, 2739], '(Sigma)': [2620], 'homogenized': [2629], 'motor-driven': [2632], 'homogenizer': [2633], '(15': [2634], 'strokes)': [2635], 'then': [2641, 3100, 3148, 3639, 3788], '760': [2644], '3': [2648], 'centrifugation,': [2654], '190,000': [2662], 'resulting': [2672], 'pellet': [2675], 'above-mentioned': [2680], 'buffer,': [2681], 'stored': [2685], 'investigate': [2699], 'whether': [2700], 'directly': [2702], 'affects': [2703], 'units': [2709], '(BIOMOL': [2712], 'Research': [2713], 'Labs': [2714], 'Inc.': [2715], '(Plymouth': [2716], 'Meeting,': [2717], 'PA)': [2718], 'incubated': [2720, 3174, 3210], 'room': [2722, 3126, 3144, 3168, 3230], 'temperature': [2723, 3127], 'without': [2729, 4102], 'reaction': [2738, 2754, 2778], 'contained': [2740], '50': [2741], 'Tris-HCl': [2743], '7.4)': [2745], 'EDTA.': [2749], 'initiated': [2756], '25': [2761], '[1-14C]arachidonic': [2763], 'sample.': [2767], 'terminated': [2780], '200': [2785, 3184], 'stop': [2789], 'diethyl': [2792, 2835], 'ether,': [2793, 2836, 2838], 'methanol,': [2794], 'm': [2797], 'citric': [2798], 'ratio': [2802, 2844], '30:4:1': [2804], '(v/v).': [2805], 'mixing,': [2807], 'centrifuged,': [2811], 'ethereal': [2814], 'extracts': [2815], 'spotted': [2817], 'silica': [2820], 'thin': [2822], 'layer': [2823, 2826], 'plate.': [2824], 'Thin': [2825], 'chromatography': [2827], 'performed': [2829, 3283, 3596], 'system': [2833, 2973], 'petroleum': [2837], 'acetic': [2840], '85:15:0.1': [2846], '(v/v)': [2847], '45–60': [2849], '–20': [2852], 'Distribution': [2854], 'radioactivity': [2857], 'substrate': [2860], 'products': [2862], 'quantified': [2867], 'analyzer.': [2871], 'GSH': [2872], 'HPLC': [2877], 'coulometric': [2878, 2945], 'electrode': [2879, 2946], 'array': [2880, 2947], 'detector': [2881, 2948], '(Coularray': [2882], 'Detector': [2883], 'Model': [2884], '5600': [2885], '12': [2887, 4321], 'channels,': [2888], 'ESA': [2889], 'Chelmsford,': [2891], 'MA).': [2892], 'Sample': [2893], 'preparation': [2894], 'mobile': [2897], 'phase': [2898], 'column': [2900], 'glutathione': [2903, 2953], 'As': [2933], 'improvement': [2935], 'reported': [2938, 3857, 3975], 'methods,': [2939], 'method': [2942, 3050], 'implemented': [2943], 'detection': [2951], '(30Roy': [2954], 'Venojarvi': [2956], '352:': [2965], '326-332Crossref': [2966], '(24)': [2969], 'uses': [2974, 3457], 'multiple': [2975], 'channels': [2976, 2985], 'different': [2978], 'redox': [2979], 'potentials.': [2980], 'Glutathione': [2981], 'set': [2986, 3005], 'potentials:': [2990], '(i)': [2991], '600': [2992], 'mV,': [2993, 2996], '(ii)': [2994], '(iii)': [2998], '800': [2999, 3007], 'mV.': [3000], 'Signals': [3001], 'channel': [3004], 'mV': [3008], 'quantification': [3012], '(31Sen': [3013], 'Babior': [3017], 'B.M.': [3018], 'Hunt': [3019], 'T.K.': [3020], 'Ellison': [3021], 'E.C.': [3022], '33284-33290Abstract': [3030], '(253)': [3038], '12-HETE': [3041], 'HPLC/UV-based': [3049], '(32Eberhard': [3051], 'Jepsen': [3053], 'Albers': [3055], 'H.K.': [3056], 'Acil': [3057], 'Anal.': [3059], 'Biochem.': [3060, 3553], '280:': [3062], '258-263Crossref': [3063], '(26)': [3066], 'immunofluorescence': [3070], 'microscopy,': [3071, 4224, 4260], 'plated': [3079, 3272], '35-mm': [3081, 3274], 'precoated': [3083, 3276], 'poly-l-lysine.': [3085, 3278], 'BL15': [3095, 4201, 4247, 4272], 'challenged': [3101, 3931, 3957, 4187], 'exposed': [3105], 'exposure,': [3113], 'three': [3117, 3150, 3236, 3717], 'fixed': [3121, 4235], '4%': [3129], 'paraformaldehyde,': [3130], 'permeabilized': [3132], 'PBS/T': [3134], '(PBS': [3135], '0.2%': [3137], 'Triton': [3138], 'X-100)': [3139], 'temperature.': [3145, 3169, 3231], 'rinsed': [3149], 'PBS/T,': [3153], 'blocking': [3155], '(2%': [3156], 'albumin': [3159], 'PBS/T)': [3161], 'done': [3163], 'blocking,': [3171], 'overnight': [3175], '(anti-neurofilament': [3183], '(diluted': [3185, 3193], '1:100;': [3186], 'Sigma)': [3187], 'anti-neuronal': [3189], 'class': [3190, 4213], 'III': [3191, 4214], 'β-tubulin': [3192, 4038, 4215], '1:500;': [3194], 'Covance,': [3195], 'CA)).': [3197], 'PBS': [3201, 3237], '(three': [3202], 'times,': [3203], 'each),': [3206], 'Alexa': [3212], 'Fluor': [3213], '488-conjugated': [3214], 'goat': [3215], 'anti-mouse': [3216], 'anti-rabbit': [3218], 'secondary': [3219, 3470], '(Molecular': [3221], 'Probes': [3222], 'In.,': [3223], 'Eugene,': [3224], 'OR)': [3225], '45': [3227], 'washes': [3238], 'mounting': [3240], 'medium.': [3243], 'Fluorescent': [3244], 'images': [3245, 4290], 'Zeiss': [3250, 3345], 'Axiovert': [3251], '200M': [3252], 'microscope.': [3253], 'Images': [3254, 3334, 3381], 'acquired': [3256], 'Axiovision': [3258, 3389], 'Version': [3259, 3390, 3410, 3703], '3.1.': [3260], 'live': [3262, 4276], 'imaging,': [3264], 'Live': [3279], 'untreated': [3285], '8': [3288, 4301, 4315], '26': [3290, 3319, 4327], '(18-h': [3292], 'duration)': [3293, 3324], 'exposure': [3296], 'because': [3297], 'time': [3301], 'when': [3302], 'morphological': [3303], 'changes': [3304], 'most': [3306], 'prominent.': [3307], 'α-Tocotrienol-treated': [3308], 'insensitive': [3311], 'imaged': [3317], '34': [3321, 4355], '(8-h': [3323], 'pattern.': [3333], 'once': [3337, 4293], 'every': [3338, 4294], 'specialized': [3343], 'phase-contrast': [3344, 4044, 4086, 4223, 4259], 'microscope': [3346, 3357], 'suited': [3347], 'growing': [3351, 4097], 'routine': [3353], 'fitted': [3359], 'appropriate': [3361], 'accessories': [3362], 'maintain': [3364], 'stage': [3366], 'gas': [3372], 'environment': [3373], 'comparable': [3374], 'exported': [3383], '.avi': [3385, 4358], 'video': [3386, 4359], 'format': [3387], '4.0.': [3391], 'Homology': [3392], 'construction': [3394], 'Silicon': [3400], 'Graphics': [3401], 'O2': [3402], 'workstation': [3403], '300-MHz': [3405], 'MIPS®': [3406], 'R5000': [3407], '(OS': [3408], 'IRIX': [3409], '6.5).': [3411], 'theoretical': [3413, 3643, 3801], 'built': [3418], 'Sybyl': [3421, 3777], 'GeneFold': [3422], 'module': [3423, 3432, 3452], '(Version': [3424, 3684, 3811], '6.8,': [3425], 'Tripos': [3426, 3599], 'Associates,': [3427], 'St.': [3428], 'Louis,': [3429], 'MO).': [3430], 'employs': [3433], 'BLAST': [3435, 3512], 'search': [3436, 3446, 3513], 'against': [3437, 3969, 4074], 'RSCB': [3439], 'Protein': [3440, 3509, 3645], 'Database': [3441], '2Available': [3442], 'www.rcsb.org/pdb.': [3444], 'possible': [3448], 'alignments.': [3450], 'identifying': [3454], 'homologous': [3455], 'proteins': [3456], 'four': [3458], 'scoring': [3459, 3496], 'functions,': [3460], 'include': [3462], 'sequence': [3463, 3500, 3516], 'similarity,': [3464, 3468], 'local': [3465], 'interactions,': [3466], 'burial': [3467], 'structure': [3471, 3572, 3619, 3674], 'similarity.': [3472], 'reflected': [3476], 'combination': [3478, 3944], '"alignment': [3481], 'score,"': [3482], 'score': [3485, 3521], '1000': [3487], 'indicating': [3488], 'perfect': [3490], 'alignment': [3491, 3520], 'regard': [3493], 'all': [3495], 'functions.': [3497], 'target': [3499, 3569], 'platelet-type': [3502], 'taken': [3505], 'NCBI': [3508], 'Database.': [3510], '97%': [3515], 'identity': [3517], '999.9': [3523], 'soybean': [3525], '1-LOX': [3526], '(Protein': [3527], 'Data': [3528, 3818], 'Bank': [3529], 'code': [3530], '1YGE)': [3531], '(33Bernstein': [3532], 'F.C.': [3533], 'Koetzle': [3534], 'T.F.': [3535], 'Williams': [3536], 'G.J.': [3537], 'Meyer': [3538], 'E.F.': [3540], 'Brice': [3541], 'M.D.': [3542], 'Rodgers': [3543], 'J.R.': [3544], 'Kennard': [3545], 'Shimanouchi': [3547], 'T.': [3548], 'Tasumi': [3549], '1977;': [3554], '80:': [3555], '319-324Crossref': [3556], '(561)': [3559], 'reflecting': [3562], 'similar': [3564], 'folding': [3565], 'pattern': [3566], 'sequence.': [3570], '1YGE': [3574], 'subsequently': [3577], 'template': [3580, 3672], 'building': [3584], '"backbone': [3587], 'method"': [3588], 'option': [3589], 'Sybyl.': [3591], 'Molecular': [3592], 'mechanics': [3593], 'calculations': [3594], 'force': [3600], 'field': [3601], 'constant': [3604], 'dielectric': [3605], '(ϵ': [3607], '2.0)': [3608], 'non-bonded': [3611], 'cutoff': [3612], 'distance': [3613], '8.0': [3615], 'Å.': [3616], 'final': [3618], 'energy-minimized': [3621], 'energy': [3624, 3754], 'convergence': [3625], 'gradient': [3626], 'value': [3627], '0.05': [3629, 3845], 'kcal/mol': [3630], 'assigning': [3632], 'Gasteiger-Hückel': [3633], 'charges.': [3634, 3785], 'iron': [3636], 'atom': [3637], 'modeled': [3640], 'model.': [3644], 'geometry': [3646], 'checked': [3648], 'PROCHECK': [3650], '(34Laskowski': [3651], 'MacArthur': [3653], 'M.W.': [3654], 'Moss': [3655], 'D.S.': [3656, 3689, 3724], 'Thornton': [3657], 'J.M.': [3658], 'Appl.': [3660], 'Crystallogr.': [3661], '26:': [3663], '283-291Crossref': [3664], 'compared': [3669], '1YGE.': [3675], 'Ligand': [3676], 'Autodock': [3683, 3700, 3712, 3722, 3760], '3.0.5)': [3685], '(35Morris': [3686], 'Goodsell': [3688], 'Halliday': [3690], 'R.S.': [3691], 'Huey': [3692], 'Hart': [3694], 'W.E.': [3695], 'Belew': [3696], 'R.K.': [3697], 'Olson': [3698, 3727], 'A.J.': [3699, 3728], 'Reference': [3701], 'Manual,': [3702], '3.0.5.': [3704], 'Scripps': [3706], 'La': [3708], 'Jolla,': [3709], 'CAe2001Google': [3710], 'compilation': [3715], 'programs:': [3718], 'Autotors,': [3719], 'Autogrid,': [3720], '(36Goodsell': [3723], 'Morris': [3725], 'Mol.': [3730], 'Recognit.': [3731], '9:': [3733], '1-5Crossref': [3734], '(1267)': [3737], 'Autotors': [3740], 'facilitates': [3741], 'input': [3743], 'ligand': [3745, 3770], 'coordinates;': [3746, 3758], 'Autogrid': [3747], 'pre-calculates': [3748], 'three-dimensional': [3750], 'grid': [3751], 'interaction': [3753], 'performs': [3761], 'simulations': [3763], 'lamarckian': [3766], 'genetic': [3767], 'algorithm.': [3768], 'constructed': [3774], 'Sketch': [3778], 'Molecule': [3779], 'option,': [3780], 'energy-minimized,': [3781], 'assigned': [3783], 'MOPAC': [3784], 'Docking': [3786], 'settings': [3793], 'parameters': [3795], 'Autodock.': [3797], 'Figures': [3798], 'dockings': [3805], 'generated': [3807], 'MOLMOL': [3809], 'software': [3810], '2K.2,': [3812], 'analysis': [3814], 'display).': [3817], 'bar': [3821], 'graphs': [3822], 'means': [3825], '±': [3826], 'S.D.': [3827], "Student's": [3828], 't': [3829], 'test': [3830, 3834], 'significance': [3836], 'difference': [3839, 3851], 'between': [3840, 3852], 'means.': [3842, 3854], 'p': [3843], '<': [3844], 'interpreted': [3847], 'significant': [3850], 'Previously,': [3855], 'protect': [3866], 'verify': [3902], 'general': [3904], 'relevance': [3905], 'effects': [3910], 'conducted': [3915], 'cells.': [3919], 'concentrations,': [3925], 'clearly': [3927], 'protected': [3928, 3968], 'neurotoxins': [3934], 'glutamate,': [3937], 'BSO': [3941, 3946], '(Fig.': [3950, 4016, 4046, 4070, 4088, 4146], '1,': [3951], 'A–C).': [3952], 'Experiments': [3953], 'only': [3967, 4055], 'loss': [3970], 'earlier': [3976], 'preserved': [4002], 'normal': [4004], 'rate': [4006], 'culture,': [4011], 'suggesting': [4012], 'intact': [4013], '1D).': [4017], 'Challenging': [4018], 'resulted': [4023], 'prominent': [4025], 'disruption': [4026, 4161], 'neural': [4030, 4220, 4256, 4312], 'evidenced': [4033], 'staining': [4036, 4216, 4252], 'neurofilament': [4040, 4251], 'microscopy': [4045, 4087], '2,': [4047, 4071, 4147], 'a–l).': [4048], 'Pretreatment': [4049], 'neurodegeneration,': [4058], 'face': [4065], 'm–p).': [4072, 4148], 'Protection': [4073], 'structural': [4076], 'alterations': [4077], 'neuron': [4081], '2).': [4089], 'able': [4092], 'successfully': [4094], 'image': [4095], 'having': [4103], 'grow': [4105], 'them': [4106], 'glass': [4108, 4285], 'coverslips.': [4109], 'Supplemental': [4110, 4369], 'Videos': [4111], 'I': [4112], 'II': [4114], 'demonstrate': [4115], 'motile.': [4128], 'prominently': [4131], 'visible': [4132], 'micrograph': [4135], 'tocotrienol-treated': [4137], 'ineffective': [4142], 'triggering': [4144], 'neurotoxicity': [4145], 'Time-lapse': [4149], 'glutamate-treated': [4152, 4280], 'arrest': [4156], 'cytostructural': [4158], 'movements': [4159], 'network.Fig.': [4164], '2Imaging': [4165], 'degeneration': [4168, 4337], 'protection': [4175], 'BL15.': [4179], 'seeding,': [4184], 'Where': [4190], 'indicated,': [4191], 'pretreated': [4194, 4331], '(250': [4198, 4334], 'nm)': [4199, 4335], '(2.5': [4202], 'μm)': [4203], 'prior': [4207], 'treatment.': [4210, 4305], 'a–d,': [4211], 'cultured': [4219, 4255], '(for': [4222, 4258], 'see': [4225, 4261], 'i–p).': [4226, 4262], 'treatment,': [4232], 'stained.': [4237], 'a,': [4238], 'control;': [4239, 4264], 'b,': [4240], 'glutamate;': [4241, 4245, 4266, 4270], 'c,': [4242], 'd,': [4246], 'e–h,': [4250], 'e,': [4263], 'f,': [4265], 'g,': [4267], 'i–p,': [4275], '(not': [4284], 'coverslip)': [4286], 'Phase-contrast': [4289], '18': [4298], 'Frames': [4306], 'illustrate': [4307], 'time-dependent': [4308], 'disintegration': [4309], 'network.': [4313], 'i,': [4314], 'treatment;': [4319, 4347], 'j,': [4320], 'h;': [4322, 4325, 4350, 4353], 'k,': [4323], '16': [4324], 'l,': [4326], 'h.': [4328, 4356], 'Glutamate-challenged': [4329], 'resisted': [4336], 'continued': [4339], 'grow.': [4341], 'm,': [4342], '28': [4343], 'n,': [4348], 'o,': [4351], '32': [4352], 'p,': [4354], 'Two': [4357], 'micrographs': [4360], 'i–l': [4362], 'm–p': [4364], 'included': [4366], 'Material.': [4370], 'Magnification': [4371], '×200.View': [4373], 'Large': [4374], 'Image': [4375], 'Figure': [4376], 'Vi': [4377]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1964545403', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 7}, {'year': 2021, 'cited_by_count': 15}, {'year': 2020, 'cited_by_count': 17}, {'year': 2019, 'cited_by_count': 13}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 16}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 11}, {'year': 2014, 'cited_by_count': 14}, {'year': 2013, 'cited_by_count': 13}, {'year': 2012, 'cited_by_count': 18}], 'updated_date': '2025-01-09T14:00:48.786296', 'created_date': '2016-06-24'}
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