Title: Opposite effect of cytochalasin B on agonist-induced respiratory burst in neutrophils and monocytes
Abstract: The effects of cytochalasin B on the respiratory burst, calcium transients and cell shape change of neutrophils and monocytes has been studied. Cytochalasin B enhanced fMLP-induced respiratory burst in neutrophils whereas the opposite effect, i.e. an inhibition close to 50%, was elicited in fMLP-stimulated monocytes. The differences did not depend on calcium homeostasis. On the basis of cell shape changes, and the well known effect of cytochalasin B on actin polymerization, the opposite effects of cytochalasin B could stem from differences between both cell types concerning the pattern of cytoskeleton-membrane interaction which could affect the recruitment and assembly of membrane-bound or cytosolic components of NADPH-oxidase.
Publication Year: 1991
Publication Date: 1991-07-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 10
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot