Hierarchy of Sorting Signals in Chimeras of Intestinal Lactase-Phlorizin Hydrolase and the Influenza Virus Hemagglutinin

Name: Work Video:
Duration: 3 min 30 s
Ralf Jacob; Ute Preuß; Petra Panzer; Marwan Alfalah; Stephanie Quack; Michael G. Roth; Hussein Y. Naim; Hassan Y. Naim
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524, 854, 943, 986, 1133, 1445, 1453, 1769, 1815, 1928, 2160, 2199, 2226, 2299, 2340, 2473, 2524, 2749, 2782, 2792, 2820, 2963, 2973, 2992, 3037, 3049, 3085, 3102, 3142, 3168, 3198, 3215, 3303, 3323, 3403, 3411, 3551, 3564, 3572, 3580, 3720, 3737, 3856, 3957, 3975, 4050, 4086, 4117, 4143, 4147, 4224, 4236, 4255, 4281, 4293, 4350], 'intestinal': [8, 214, 1490, 1682, 2341, 2891, 3216, 3304, 3894, 4239], 'cells.': [9, 215, 1771, 2513, 2900, 4352], 'The': [10, 80, 138, 216, 286, 344, 571, 1991, 2106, 2165, 2719, 2778, 2801, 2814, 2938, 2980, 3042, 3114, 3256, 3291, 3406, 3414, 3507, 3575, 3583, 3676, 3731, 3810, 4018, 4045, 4077, 4113, 4244, 4298, 4328, 4436], 'location': [11, 217], 'of': [12, 23, 36, 50, 57, 61, 105, 135, 140, 157, 189, 218, 229, 242, 256, 263, 267, 311, 341, 346, 363, 395, 460, 588, 592, 599, 741, 849, 858, 868, 877, 882, 894, 897, 1124, 1136, 1152, 1252, 1313, 1478, 1488, 1504, 1522, 1532, 1546, 1561, 1569, 1577, 1681, 1718, 1723, 1726, 1763, 1819, 1940, 1954, 2023, 2061, 2167, 2185, 2236, 2302, 2337, 2418, 2468, 2481, 2516, 2568, 2601, 2691, 2729, 2829, 2849, 2864, 2890, 2902, 2907, 2914, 3023, 3098, 3136, 3140, 3160, 3178, 3196, 3211, 3280, 3299, 3382, 3420, 3434, 3469, 3495, 3501, 3510, 3525, 3555, 3589, 3603, 3638, 3664, 3670, 3679, 3694, 3724, 3733, 3735, 3749, 3804, 3812, 3854, 3872, 3876, 3882, 3947, 3950, 4029, 4074, 4092, 4115, 4177, 4234, 4267, 4278, 4284, 4296, 4301, 4303, 4332, 4400, 4419, 4429, 4439], 'sorting': [13, 144, 170, 178, 188, 202, 219, 350, 376, 384, 394, 408, 455, 576, 871, 1130, 1154, 1307, 1327, 1423, 1431, 1450, 1465, 1480, 1503, 1721, 1725, 1777, 1831, 1932, 3846, 3878, 4295, 4302, 4326, 4335, 4404], 'signals': [14, 45, 49, 54, 156, 171, 179, 203, 220, 251, 255, 260, 362, 377, 385, 409, 851, 869, 1308, 1434, 1439, 1459, 1481, 1778, 1827, 1832, 1933, 4344, 4349, 4363], 'LPH': [16, 28, 37, 107, 147, 159, 222, 234, 243, 313, 353, 365, 1562, 1673, 1729, 1751, 1945, 1992, 2024, 2763, 2865, 3141, 3161, 3437, 3470, 3496, 3606, 3639, 3665, 3769, 3834, 4304, 4408], 'was': [17, 102, 148, 223, 308, 354, 1318, 1767, 2113, 2140, 2173, 2344, 2388, 2450, 2461, 2487, 2528, 2809, 2816, 2835, 2844, 2883, 2909, 2999, 3027, 3100, 3207, 4035, 4072, 4082, 4140, 4252, 4308], 'investigated': [18, 224, 3744], 'by': [19, 39, 225, 245, 941, 1268, 1441, 1749, 2087, 2175, 2330, 2333, 2464, 2491, 2654, 2689, 2723, 2818, 2894, 2942, 3001, 3559, 3728, 3745], 'preparing': [20, 226], 'a': [21, 141, 196, 227, 347, 402, 447, 586, 1128, 1322, 1454, 1476, 1519, 1529, 1540, 1727, 2149, 2154, 2178, 2227, 2447, 2598, 2847, 2912, 3020, 3038, 3128, 3149, 3199, 3277, 3466, 3565, 3635, 4276], 'series': [22, 228, 1477], 'mutants': [24, 56, 108, 230, 262, 314, 1766, 4358], 'that': [25, 41, 123, 168, 182, 187, 231, 247, 329, 374, 388, 393, 457, 1259, 1384, 1418, 1425, 1823, 2446, 2858, 3105, 3167, 3210, 3419, 3588, 3792, 3849, 3868, 3981, 4124, 4138, 4262, 4320, 4342, 4414], 'lacked': [26, 232], 'the': [27, 33, 58, 62, 77, 99, 106, 113, 117, 124, 132, 153, 158, 233, 239, 264, 268, 283, 305, 312, 319, 323, 330, 338, 359, 364, 471, 507, 513, 596, 855, 874, 891, 1137, 1140, 1145, 1150, 1262, 1302, 1310, 1314, 1390, 1446, 1464, 1483, 1502, 1552, 1570, 1574, 1678, 1713, 1719, 1757, 1783, 1816, 1943, 1948, 1955, 1995, 2018, 2055, 2116, 2144, 2161, 2183, 2186, 2237, 2300, 2351, 2378, 2385, 2399, 2410, 2425, 2453, 2477, 2602, 2714, 2727, 2744, 2783, 2807, 2842, 2887, 2896, 2958, 3025, 3069, 3134, 3137, 3153, 3157, 3176, 3179, 3205, 3261, 3267, 3296, 3421, 3428, 3472, 3490, 3498, 3522, 3526, 3552, 3590, 3597, 3641, 3659, 3667, 3691, 3695, 3721, 3738, 3793, 3807, 3813, 3817, 3823, 3839, 3843, 3869, 3948, 3976, 4026, 4051, 4057, 4069, 4087, 4096, 4118, 4144, 4152, 4171, 4225, 4249, 4256, 4263, 4282, 4288, 4294, 4333, 4340, 4367, 4371, 4398, 4401, 4407, 4410, 4417, 4424, 4440], 'cytoplasmic': [29, 34, 59, 133, 235, 240, 265, 339, 856, 1125, 1253, 1311, 1429, 1530, 1761, 1817, 1996, 2059, 2163, 3138, 3158, 3407, 3429, 3473, 3499, 3508, 3529, 3553, 3576, 3598, 3642, 3668, 3677, 3698, 3722], 'domain': [30, 35, 60, 161, 236, 241, 266, 367, 474, 1312, 1392, 1531, 1762, 1818, 2022, 2060, 3423, 3430, 3474, 3494, 3500, 3509, 3530, 3592, 3599, 3643, 3663, 3669, 3678, 3699, 3819, 4428], 'or': [31, 162, 237, 368, 738, 880, 1449, 2153, 2268, 2325, 2522, 2557, 2588, 2611, 2693, 2716, 2946, 2957, 3548, 3717, 3740], 'had': [32, 238], 'replaced': [38, 244], 'sequences': [40, 246, 590, 1126, 1254, 1755, 3381, 3400, 3569, 4413], 'comprised': [42, 248], 'basolateral': [43, 78, 143, 169, 190, 249, 284, 349, 375, 396, 597, 864, 1129, 1306, 1430, 1458, 1479, 1776, 1830, 1931, 2717, 3741, 3840, 4334, 4343, 4362, 4368], 'targeting': [44, 74, 250, 280, 3853, 4283], 'and': [46, 90, 95, 185, 252, 296, 301, 391, 437, 450, 462, 585, 988, 1497, 1528, 1548, 1555, 1685, 1715, 1745, 1753, 1779, 1828, 2020, 2054, 2158, 2169, 2194, 2221, 2310, 2332, 2384, 2412, 2493, 2574, 2678, 2756, 2772, 2806, 2841, 2855, 2861, 2904, 2976, 3018, 3052, 3145, 3165, 3217, 3276, 3326, 3372, 3379, 3387, 3427, 3492, 3497, 3596, 3661, 3666, 3751, 3799, 3845, 3852, 3867, 3892, 4012, 4025, 4068, 4108, 4274, 4311, 4330, 4426], 'overlapping': [47, 253], 'internalization': [48, 254, 1826, 1949], 'various': [51, 257, 4015], 'potency.': [52, 258], 'These': [53, 165, 259, 371, 1415, 2837, 4132], 'are': [55, 172, 261, 378, 852, 884, 3401, 3409, 3503, 3557, 3570, 3578, 3672, 3726, 4345, 4433], 'influenza': [63, 269, 412, 1315, 3888], 'hemagglutinin': [64, 270, 414, 1316], '(HA),': [65, 271], 'which': [66, 272, 2147, 2470], 'have': [67, 273, 845, 1321, 3896], 'been': [68, 274, 578, 846, 1386, 2000, 3897], 'shown': [69, 275, 1319, 3402, 3571, 3898], 'to': [70, 76, 98, 112, 129, 151, 276, 282, 304, 318, 335, 357, 470, 506, 515, 595, 863, 873, 890, 1009, 1034, 1139, 1261, 1320, 1389, 1428, 1463, 1482, 1572, 1677, 1756, 1782, 1925, 1952, 1965, 2142, 2182, 2382, 2404, 2408, 2413, 2420, 2456, 2476, 2596, 2712, 2726, 2758, 2885, 3029, 3209, 3520, 3689, 3831, 3861, 3899, 4169, 4287, 4339, 4360, 4366, 4423], 'be': [71, 277, 3374, 3521, 3690, 3900, 4222], 'dominant': [72, 175, 278, 381, 1323, 1829, 4346], 'HA': [75, 125, 281, 331, 1765, 1774, 1820, 1956, 2062, 2162, 2485, 3502, 3511, 3528, 3556, 3671, 3680, 3697, 3725, 4357, 4420, 4441], 'membrane.': [79, 115, 285, 321, 2479], 'LPH-HA': [81, 118, 287, 324, 2145, 2171, 2326, 2338, 2558, 2959, 3388], 'chimeras': [82, 119, 288, 325, 2146, 2327, 2339, 2559, 2960, 4432], 'were': [83, 109, 120, 127, 289, 315, 326, 333, 1821, 1962, 2085, 2197, 2231, 2297, 2316, 2328, 2380, 2401, 2427, 2560, 2590, 2613, 2621, 2682, 2721, 2746, 2764, 2780, 2804, 2839, 2940, 2961, 2971, 2982, 3013, 3044, 3071, 3106, 3116, 3743, 3836, 4005, 4020, 4102, 4364, 4421], 'expressed': [84, 290, 2603], 'Madin-Darby': [86, 292, 417, 1686], 'canine': [87, 293, 418, 1687], 'kidney': [88, 294, 419, 1688], '(MDCK)': [89, 295, 1689], 'colon': [91, 297, 2897], 'carcinoma': [92, 298, 2898], '(Caco-2)': [93, 299], 'cells,': [94, 300, 879, 1492], 'their': [96, 302, 517, 1499, 1926, 3955], 'transport': [97, 303, 469, 594, 1012, 1135, 1147, 1260, 3144], 'cell': [100, 306, 739, 2430, 2454, 2465, 2679, 3201, 3746, 3978], 'surface': [101, 307, 473, 598, 876, 893, 1264, 1785, 2431, 2466, 2680, 3747], 'analyzed.': [103, 309], 'All': [104, 310, 848, 3568], 'targeted': [110, 316, 1675, 2472], 'correctly': [111, 317], 'Furthermore,': [116, 322], 'internalized,': [121, 327], 'indicating': [122, 328], 'tails': [126, 332, 4438], 'available': [128, 334], 'interact': [130, 336], 'with': [131, 337, 446, 981, 1542, 2177, 2210, 2233, 2318, 2406, 2433, 2484, 2565, 2579, 2609, 2623, 2770, 2788, 2811, 2846, 2911, 2953, 2987, 3004, 3032, 3055, 3067, 3073, 3108, 3118, 3127, 3903, 3973, 4007, 4022, 4095, 4104, 4129, 4135, 4271, 4354], 'components': [134, 340], 'clathrin-coated': [136, 342], 'pits.': [137, 343], 'introduction': [139, 345], 'strong': [142, 154, 348, 360, 4324], 'signal': [145, 351, 1131, 1722, 2754, 4405], 'into': [146, 352, 465, 1309, 2115, 3266], 'not': [149, 173, 355, 379, 1032, 1266, 1935, 3174, 4127, 4292], 'sufficient': [150, 356, 2451], 'override': [152, 358], 'external': [160, 366, 1752, 2019, 3491, 3660], 'transmembrane': [163, 369, 859, 1121, 1391, 1754, 2021, 3422, 3493, 3591, 3662, 4427], 'domains.': [164, 370], 'results': [166, 372, 523, 1132, 4101], 'show': [167, 373], 'always': [174, 380], 'over': [176, 382, 1325, 1437, 2774, 4347], 'proteins': [181, 193, 387, 399, 461, 514, 872, 889, 1007, 1037, 1420, 1747, 1946, 3099], 'contain': [183, 389, 2148, 4361], 'each': [184, 390, 445, 2170], 'suggest': [186, 392, 4319], 'from': [191, 397, 2684, 3755, 3816, 4151], 'occurs': [194, 400], 'within': [195, 401, 4406], 'common': [197, 403, 1455], 'compartment': [198, 404, 1456], 'where': [199, 405, 1457], 'competition': [200, 406], 'for': [201, 407, 468, 512, 575, 582, 870, 1149, 2429, 2441, 2452, 2511, 2562, 2576, 2593, 2616, 2753, 2767, 2785, 2823, 2984, 3019, 3034, 3058, 3090, 3766, 4009, 4014], 'can': [204, 410], 'occur.': [205, 411], 'virus': [413, 3889], 'lactase-phlorizin': [415, 1493], 'cells': [420, 433, 439, 601, 899, 1684, 1690, 2193, 2196, 2296, 2343, 2379, 2400, 2411, 2419, 2426, 2475, 2483, 2518, 2583, 2607, 2686, 2761, 2779, 2950, 2970, 2981, 3043, 3070, 3104, 3115, 3170, 3219, 3328, 3756, 3858, 4019, 4241], 'polyacrylamide': [421], 'gel': [422], 'electrophoresis': [423, 2743], 'monoclonal': [424, 2851, 2915], 'antibody': [425, 2711, 2998, 3078], 'phosphate-buffered': [426], 'saline': [427], "Dulbecco's": [428, 2200], 'modified': [429, 2201], "Eagle's": [430, 2202], 'medium': [431, 2203], 'Polarized': [432], 'such': [434, 3886, 3959], 'as': [435, 1539, 2083, 2246, 2489, 2530, 2652, 3505, 3674, 3763, 3887, 3960], 'neurons': [436, 742], 'epithelial': [438, 600, 878, 898, 1491, 1683], 'maintain': [440], 'separate': [441, 466], 'plasma': [442], 'membrane': [443, 509, 983, 1486, 1511, 1520, 1680, 2348, 3761, 4373], 'domains,': [444], 'distinct': [448], 'lipid': [451], 'composition,': [452], 'through': [453], 'intracellular': [454, 3850], 'mechanisms': [456], 'recognize': [458, 2859], 'classes': [459], 'deliver': [463], 'them': [464], 'vesicles': [467], 'correct': [472, 508], '(1Nelson': [475], 'W.J.': [476], 'Science.': [477, 931], '1992;': [478, 1053, 1091, 1647, 1665, 2076, 3541, 3710, 3927], '258:': [479], '948-955Crossref': [480], 'PubMed': [481, 500, 541, 568, 618, 646, 659, 681, 696, 715, 735, 763, 779, 794, 815, 840, 920, 935, 961, 976, 998, 1023, 1073, 1094, 1116, 1170, 1190, 1210, 1225, 1243, 1280, 1298, 1346, 1364, 1379, 1410, 1595, 1616, 1632, 1650, 1668, 1708, 1807, 1850, 1867, 1883, 1901, 1918, 2049, 2079, 2132, 2265, 2290, 2374, 2508, 2550, 2647, 2675, 2708, 2737, 2933, 3231, 3253, 3318, 3346, 3367, 3459, 3544, 3628, 3713, 3787, 3914, 3930, 3941, 4001, 4162, 4198, 4218, 4391], 'Scopus': [482, 501, 542, 619, 660, 682, 697, 716, 764, 780, 795, 816, 841, 921, 936, 962, 977, 999, 1024, 1095, 1171, 1191, 1211, 1226, 1244, 1281, 1347, 1380, 1411, 1596, 1617, 1633, 1669, 1808, 1851, 1868, 1884, 1919, 2050, 2133, 2648, 2738, 2934, 3232, 3319, 3368, 3460, 3629, 3915, 3931, 3942, 4163, 4199, 4392], '(174)': [483], 'Google': [484, 503, 544, 569, 621, 647, 662, 684, 699, 718, 736, 766, 782, 797, 818, 843, 923, 938, 964, 979, 1001, 1026, 1056, 1074, 1097, 1117, 1173, 1193, 1213, 1228, 1246, 1283, 1299, 1349, 1365, 1382, 1413, 1598, 1619, 1635, 1651, 1671, 1709, 1743, 1810, 1853, 1870, 1886, 1902, 1921, 2014, 2052, 2080, 2104, 2135, 2266, 2291, 2375, 2509, 2551, 2650, 2676, 2709, 2740, 2877, 2936, 3192, 3234, 3254, 3321, 3347, 3370, 3462, 3486, 3545, 3631, 3655, 3714, 3788, 3917, 3933, 3944, 4002, 4165, 4201, 4219, 4394], 'Scholar,': [485, 545, 622, 648, 663, 685, 700, 719, 767, 783, 798, 819, 924, 965, 1057, 1075, 1098, 1174, 1194, 1214, 1229, 1284, 1350, 1366, 1599, 1620, 1636, 1652, 1854, 1871, 1887, 1903, 3235, 3348, 3918, 3934, 4202], '2Wandinger-Ness': [486], 'A.': [487, 804, 907, 916, 948, 1059, 1079, 1081, 1083, 1180, 1609, 1795, 2640, 2926, 4191], 'Bennett': [488], 'M.K.': [489], 'Antony': [490], 'C.': [491, 626, 709, 748, 750, 800, 1106, 1164, 1198, 1218, 1694, 2276, 2536, 3239, 3332, 3773, 3987], 'Simons': [492, 770, 788, 968, 1017], 'K.': [493, 632, 707, 771, 789, 952, 969, 991, 1018, 1102, 1162, 1200, 3907], 'J.': [494, 535, 549, 562, 612, 637, 653, 670, 690, 711, 726, 757, 809, 829, 955, 970, 1016, 1041, 1050, 1064, 1107, 1166, 1219, 1274, 1289, 1335, 1355, 1373, 1399, 1610, 1628, 1645, 1699, 1737, 1791, 1839, 1861, 1873, 1892, 1912, 1970, 2008, 2045, 2074, 2126, 2256, 2281, 2365, 2499, 2541, 2641, 2666, 2699, 2871, 2927, 3186, 3227, 3244, 3314, 3337, 3356, 3362, 3455, 3480, 3539, 3624, 3649, 3708, 3778, 3992, 4192, 4209, 4380], 'Cell': [495, 536, 563, 613, 654, 691, 758, 810, 956, 971, 1051, 1089, 1275, 1374, 1611, 1738, 1862, 1913, 2009, 2127, 2619, 2642, 2872, 2928, 3187, 3481, 3650, 3925, 4193], 'Biol.': [496, 537, 614, 638, 655, 671, 692, 727, 759, 811, 830, 957, 972, 1065, 1108, 1276, 1290, 1336, 1356, 1375, 1400, 1612, 1700, 1739, 1840, 1863, 1893, 1914, 2010, 2128, 2257, 2282, 2366, 2500, 2542, 2643, 2667, 2700, 2873, 2929, 3188, 3245, 3338, 3482, 3651, 3779, 3926, 3993, 4194, 4210, 4381], '1990;': [497, 773, 958, 2101], '111:': [498], '987-1000Crossref': [499], '(216)': [502], 'Scholar).': [504, 570, 1002, 1118, 1247, 1300, 1414, 1672, 1710, 1922, 1990, 2015, 2105, 2136, 2292, 2376, 2552, 2741, 2878, 2937, 3193, 3255, 3463, 3487, 3546, 3632, 3656, 3715, 3789, 3945, 4003, 4166, 4395], 'Sorting': [505], 'essential': [511], 'exhibit': [516], 'biological': [518], 'functions,': [519], 'whereas': [520], 'missorting': [521], 'often': [522], 'pathological': [525], 'conditions': [526], '(3Fransen': [527], 'J.A.': [528], 'Hauri': [529, 554], 'H.P.': [530, 555, 1601, 2632, 2918, 4183], 'Ginsel': [531, 556], 'L.A.': [532], 'Naim': [533, 558, 666, 1331, 1395, 1697, 1734, 1835, 2005, 2279, 2492, 2539, 2655, 2868, 3183, 3242, 3335, 3359, 3477, 3646, 3776, 3990, 4376], 'H.Y.': [534, 559, 667, 1332, 1396, 1622, 1698, 1733, 1836, 2004, 2249, 2280, 2540, 2659, 2867, 3182, 3221, 3243, 3308, 3336, 3360, 3476, 3645, 3777, 3991, 4204, 4377], '1991;': [538, 791, 1110, 1204, 1376, 1864, 2129, 2259, 2368, 2669], '115:': [539], '45-57Crossref': [540], '(51)': [543, 1227], '4Moolenaar': [546], 'C.E.C.': [547], 'Ouwendijk': [548], 'Wittpoth': [550], 'M.': [551, 630, 636, 745, 903, 1216, 2031, 3354, 3441, 3610], 'Wisselaar': [552], 'H.A.': [553], 'LA.': [557], 'Fransen': [560, 1606, 1695, 2277, 2537, 2637, 2923, 3240, 3333, 3774, 3988, 4188], 'J.A.M.': [561, 1607, 1696, 2278, 2538, 2638, 2924, 3241, 3334, 3775, 3989, 4189], 'Sci.': [564, 913, 1052], '1997;': [565, 673, 693, 832, 995, 1240, 1277, 1338, 1402, 1842, 3911, 4383], '110:': [566, 959], '557-567Crossref': [567], 'recognition': [572], 'event': [573], 'responsible': [574], 'has': [577, 1385, 1999, 4337], 'under': [579], 'intense': [580], 'investigation': [581], 'two': [583, 2850, 3065, 3833, 4040], 'decades,': [584], 'number': [587, 3881], 'peptide': [589], 'capable': [591], 'specifying': [593], '(5Aroeti': [602], 'B.': [603, 628, 928, 1640, 2069, 3534, 3703], 'Kosen': [604], 'P.A.': [605], 'Kuntz': [606], 'I.D.': [607], 'Cohen': [608], 'F.E.': [609], 'Mostov': [610, 951], 'K.E.': [611, 1176], '1993;': [615, 640, 712, 729, 1067, 1167], '123:': [616], '1149-1160Crossref': [617], '(120)': [620], '6Geffen': [623], 'I.': [624, 1202, 3352], 'Fuhrer': [625], 'Leitinger': [627], 'Weiss': [629], 'Huggel': [631], 'Griffiths': [633], 'G.': [634, 687, 1271, 1660, 2043, 3453, 3622], 'Spiess': [635], 'Chem.': [639, 672, 728, 831, 1066, 1109, 1291, 1337, 1357, 1401, 1701, 1841, 1894, 2258, 2283, 2367, 2501, 2543, 2668, 2701, 3246, 3339, 3780, 3994, 4211, 4382], '268:': [641, 730, 1068], '20772-20777Abstract': [642], 'Full': [643, 676, 678, 732, 776, 835, 837, 1070, 1113, 1187, 1207, 1295, 1341, 1343, 1361, 1405, 1407, 1705, 1804, 1845, 1847, 1880, 1898, 2262, 2287, 2371, 2505, 2547, 2672, 2705, 3250, 3343, 3784, 3998, 4215, 4386, 4388], 'Text': [644, 677, 679, 733, 777, 836, 838, 1071, 1114, 1188, 1208, 1296, 1342, 1344, 1362, 1406, 1408, 1706, 1805, 1846, 1848, 1881, 1899, 2263, 2288, 2372, 2506, 2548, 2673, 2706, 3251, 3344, 3785, 3999, 4216, 4387, 4389], 'PDF': [645, 680, 734, 778, 839, 1072, 1115, 1189, 1209, 1297, 1345, 1363, 1409, 1707, 1806, 1849, 1882, 1900, 2264, 2289, 2373, 2507, 2549, 2674, 2707, 3252, 3345, 3786, 4000, 4217, 4390], '7Honing': [649], 'S.': [650, 665, 915, 1061, 1330, 1394, 1834, 2189, 4375], 'Hunziker': [651, 753, 2040, 3450, 3619], 'W.': [652, 754, 1104, 1196, 2037, 2041, 2364, 3447, 3451, 3616, 3620], '1995;': [656, 760, 812, 1020, 1222, 1915, 3938, 4159], '128:': [657, 813], '321-332Crossref': [658], '(118)': [661], '8Lin': [664], 'Roth': [668, 724, 1287, 1333, 1353, 1371, 1397, 1643, 1837, 1859, 1874, 1890, 1910, 2072, 2124, 2494, 2497, 2697, 3537, 3706, 4378], 'M.G.': [669, 725, 1288, 1334, 1354, 1372, 1398, 1644, 1787, 1838, 1860, 1875, 1891, 1911, 2073, 2125, 2498, 2698, 3538, 3707, 4379], '272:': [674, 833, 1339, 1403, 1843, 4384], '26300-26305Abstract': [675, 1340, 1404, 1844, 4385], '(30)': [683, 1348, 1412, 1852, 4393], '9Odorizzi': [686], 'Trowbridge': [688, 1272], 'I.S.': [689, 1273], '137:': [694, 1278], '1255-1264Crossref': [695, 1279], '(121)': [698, 1282], '10Prill': [701], 'V.': [702, 1157], 'Lehmann': [703, 1158], 'L.': [704, 905, 1159, 1793], 'von': [705, 746, 1160], 'Figura': [706, 1161], 'Peters': [708, 1163], 'EMBO': [710, 1165, 2044, 3454, 3623], '12:': [713, 1168], '2181-2193Crossref': [714, 1169], '(88)': [717, 1172], '11Thomas': [720], 'D.C.': [721, 1286, 1352], 'Brewer': [722, 1693, 1908, 2275, 2535, 3238, 3331, 3772, 3986], 'C.B.': [723, 1368, 1856, 1909, 2121], '3313-3320Abstract': [731], 'Scholar),': [737, 844, 939, 1027, 1811, 2677, 3322, 3371, 4220], 'body': [740], '(12de': [743], 'Hoop': [744], 'Poser': [747], 'Lange': [749], 'Ikonen': [751, 992, 3908], 'E.': [752, 828, 909, 954, 993, 1662, 3909, 3920], 'Dotti': [755], 'C.G.': [756, 769, 785], '130:': [761], '1447-1459Crossref': [762], '(55)': [765], '13Dotti': [768], 'Cell.': [772, 1183, 1203, 1220, 1800, 1876], '62:': [774], '63-72Abstract': [775], '(364)': [781], '14Dotti': [784], 'Parton': [786], 'R.G.': [787], 'Nature.': [790, 994, 1019, 2733, 3910], '349:': [792], '158-161Crossref': [793], '(205)': [796], '15Haass': [799], 'Koo': [801], 'E.H.': [802], 'Capell': [803], 'Teplow': [805], 'D.B.': [806], 'Selkoe': [807], 'D.J.': [808], '537-547Crossref': [814], '(125)': [817], '16Le': [820], 'Gall': [821], 'A.H.': [822], 'Powell': [823, 3921], 'S.K.': [824, 3922], 'Yeaman': [825], 'C.A.': [826], 'Rodriguez-Boulan': [827, 908, 953], '4559-4567Abstract': [834], '(56)': [842], 'characterized.': [847], 'these': [850, 1472, 1930, 3832, 3951, 4279], 'located': [853], 'domains': [857, 984, 3408, 3577, 3742], 'glycoproteins.': [860], 'In': [861, 1301, 1923], 'addition': [862, 2690], 'signals,': [865], 'three': [866, 3002], 'types': [867, 896], 'axon': [881], 'neurons,': [883], 'known.': [885], 'Glycolipid': [886], 'anchors': [887], 'direct': [888], 'several': [895, 1764, 2775], '(17Lisanti': [900], 'M.P.': [901], 'Sargiacomo': [902], 'Graeve': [904], 'Saltiel': [906], 'Proc.': [910], 'Natl.': [911], 'Acad.': [912], 'U.': [914], '1988;': [917, 1877, 2046, 3456, 3625, 4212], '85:': [918], '9557-9561Crossref': [919], '(309)': [922], '18Brown': [925], 'D.A.': [926], 'Crise': [927], 'Rose': [929], 'J.K.': [930], '1989;': [932], '245:': [933], '1499-1501Crossref': [934], '(319)': [937], 'apparently': [940], 'associating': [942], 'thetrans-Golgi': [944], 'network': [945], '(19Le': [946], 'Bivic': [947], 'Sambuy': [949], 'Y.': [950], '1533-1539Crossref': [960], '(115)': [963], '20Matlin': [966], 'K.S.': [967], '1984;': [973, 1592], '99:': [974], '2131-2139Crossref': [975], '(150)': [978], 'Scholar)': [980, 1383, 1744, 2053, 2081, 2267, 2510, 2651, 2710], 'detergent-insoluble': [982], 'enriched': [985], 'glycosphingolipids': [987], 'cholesterol': [989], '(21Simons': [990, 3906], '387:': [996, 3912], '569-572Crossref': [997, 3913], '(8270)': [1000, 3916], 'Oligosaccharides': [1003], 'on': [1004, 1501, 2347, 2397, 2520, 2687, 2944, 2965, 2978, 3046, 3758, 4248], 'some': [1005, 1419, 3893], 'secreted': [1006, 1036], 'appear': [1008], 'specify': [1010], '(22Scheiffele': [1013], 'P.': [1014, 1077, 1658, 2039, 3449, 3618], 'Peranen': [1015], '378:': [1021], '96-98Crossref': [1022], '(418)': [1025], 'although': [1028], 'this': [1029, 3171, 4075, 4285, 4321, 4355], 'mechanism': [1030], 'does': [1031, 1265], 'apply': [1033], 'all': [1035], '(23Soole': [1038], 'K.L.': [1039], 'Hall': [1040], 'Jepson': [1042], 'M.A.': [1043], 'Hazlewood': [1044], 'G.P.': [1045], 'Gilbert': [1046], 'H.J.': [1047], 'Hirst': [1048], 'B.H.': [1049], '102:': [1054], '495-504PubMed': [1055], '24Gonzalez': [1058], 'Nicovani': [1060], 'Juica': [1062], 'F.': [1063], '6662-6667Abstract': [1069], '25Ragno': [1076], 'Estreicher': [1078], 'Gos': [1080], 'Wohlwend': [1082], 'Belin': [1084], 'D.': [1085, 1370, 1605, 1654, 1797, 1858, 2123, 2636, 2922, 4187], 'Vassalli': [1086], 'J.D.': [1087], 'Exp.': [1088], 'Res.': [1090, 1237, 1590], '203:': [1092], '236-243Crossref': [1093], '(24)': [1096], '26Ullrich': [1099], 'O.': [1100, 1585], 'Mann': [1101], 'Haase': [1103], 'Koch-Brandt': [1105], '266:': [1111, 2260, 2369, 2670], '3518-3525Abstract': [1112], 'For': [1119, 1248, 2393], 'many': [1120], 'glycoproteins,': [1122], 'deletion': [1123, 1151, 1251, 3172], 'containing': [1127, 1518, 2831, 3006, 3489, 3658], 'efficient': [1134], 'surface,': [1142], 'rather': [1143, 4369], 'than': [1144, 1467, 4110, 4306, 4370], 'random': [1146], 'expected': [1148], 'specific': [1153], 'information': [1155, 1328, 1424], '(10Prill': [1156], '27Mostov': [1175], 'de': [1177], 'Bruyn': [1178], 'Kops': [1179], 'Deitcher': [1181], 'D.L.': [1182], '1986;': [1184], '47:': [1185], '359-364Abstract': [1186], '(133)': [1192], '28Hunziker': [1195], 'Harter': [1197], 'Matter': [1199], 'Mellman': [1201], '66:': [1205, 1648, 2077, 3542, 3711], '907-920Abstract': [1206], '(245)': [1212], '29Hobert': [1215], 'Carlin': [1217], 'Physiol.': [1221], '162:': [1223], '434-446Crossref': [1224], '30Ball': [1230], 'J.M.': [1231], 'Mulligan': [1232], 'M.J.': [1233, 1626, 1789, 3225, 3312, 4208], 'Compans': [1234, 1798], 'R.W.': [1235, 1799], 'AIDS': [1236], 'Hum.': [1238], 'Retroviruses.': [1239], '13:': [1241], '665-675Crossref': [1242], '(19)': [1245], 'other': [1249, 4250], 'proteins,': [1250, 3885, 3895], 'caused': [1255], 'randomized': [1256], 'transport,': [1257], 'proving': [1258], 'occur': [1267, 1452], 'default': [1269], '(9Odorizzi': [1270], '31Thomas': [1285, 1351], '1994;': [1292, 1358, 1702, 1895, 2284, 2502, 2544, 2702, 3247, 3340, 3781, 3995], '269:': [1293, 1359, 1703, 1896, 2285, 2503, 2545, 2703, 3248, 3341, 3782, 3996], '15732-15739Abstract': [1294, 1360], 'reverse': [1303], 'approach,': [1304], 'introducing': [1305], '(HA)1': [1317], 'effect': [1324, 1500], '(8Lin': [1329, 1393, 1833, 4374], '32Brewer': [1367, 1855], 'Thomas': [1369, 1857, 2122], '114:': [1377, 1865, 2130], '413-421Crossref': [1378, 1866, 2131], '(224)': [1381, 1869, 2134], 'recently': [1387], 'localized': [1388], 'observations': [1416, 4137], 'implied': [1417], 'carry': [1421], 'recessive': [1427], 'signals.': [1432, 1469, 3879, 4327], 'Basolateral': [1433], 'could': [1435, 1451, 4221], 'dominate': [1436], 'simply': [1440], 'being': [1442], 'recognized': [1443], 'earlier': [1444, 4107], 'biosynthetic': [1447, 2439, 3259, 4031], 'pathway,': [1448], 'might': [1460], 'bind': [1461], 'tighter': [1462], 'machinery': [1466, 4336], 'To': [1470, 1711, 3132, 4396], 'investigate': [1471, 1712], 'questions,': [1473], 'we': [1474, 3147], 'attached': [1475], 'strictly': [1484, 1676], 'polarized': [1485, 3977], 'small': [1489, 4154], '(LPH,': [1495], 'EC3.2.1.23-3.2.1.62),': [1496], 'determined': [1498, 2174], 'LPH.': [1505, 1941, 4297], 'LPH,': [1506, 1724, 3385], 'integral': [1508], 'type': [1509, 1773, 3213, 3384, 3436, 3605, 3768, 3864], 'I': [1510], 'glycoprotein,': [1512], '1927': [1514], 'amino': [1515, 1526, 1534, 3425, 3432, 3514, 3594, 3601, 3683], 'acids': [1516, 1527, 2026, 2064], 'long': [1517], 'anchor': [1521], '19': [1523], 'contiguous': [1524], 'hydrophobic': [1525], '26': [1533], 'acids.': [1535, 3515, 3684], 'It': [1536], 'synthesized': [1538], 'precursor': [1541, 1571, 3798], 'apparent': [1543, 3283], 'molecular': [1544, 3284], 'masses': [1545], '215': [1547], '230': [1549], 'kDa,': [1550], 'representing': [1551], 'mannose-rich': [1553, 3263, 4047, 4097, 4245], '(pro-LPHh)': [1554], 'complex': [1556, 1567, 3268, 3794, 4078, 4173], '(pro-LPHc)': [1557], 'glycosylated': [1558, 3269, 3795, 4079, 4174], 'forms.': [1559], 'Maturation': [1560], 'involves': [1563], 'proteolytic': [1564], 'cleavage': [1565], 'after': [1566, 2311, 2438, 3112, 3273, 3801, 4089, 4231], 'glycosylation': [1568], 'yield': [1573], 'brush-border': [1575, 2892, 4179], 'form': [1576, 3279, 3294, 3468, 3637, 4146, 4176, 4246, 4266], '160': [1578, 3286], 'kDa': [1579], '(33Danielsen': [1580], 'E.M.': [1581, 3936, 4157], 'Skovbjerg': [1582], 'H.': [1583, 1587, 1638, 1735, 1889, 1905, 2006, 2035, 2067, 2496, 2696, 2869, 3184, 3445, 3478, 3532, 3614, 3647, 3701], 'Noren': [1584], 'Sjöström': [1586], 'Biochem.': [1588, 1627, 3226, 3313, 3363], 'Biophys.': [1589], 'Commun.': [1591], '122:': [1593], '82-90Crossref': [1594], '(71)': [1597], '34Hauri': [1600], 'Sterchi': [1602, 1623, 1661, 2633, 2919, 3222, 3309, 3357, 4184, 4205], 'E.E.': [1603, 1624, 2634, 2920, 3223, 3310, 3358, 4185, 4206], 'Bienz': [1604, 2635, 2921, 4186], 'Marxer': [1608, 2639, 2925, 4190], '1985;': [1613, 2644, 2930, 4195], '101:': [1614, 2645, 2931, 4196], '838-851Crossref': [1615, 2646, 2932, 4197], '(396)': [1618, 2649, 2935, 4200], '35Naim': [1621], 'Lentze': [1625, 3224, 3311, 4207], '1987;': [1629, 3228, 3315], '241:': [1630, 3229, 3316], '427-434Crossref': [1631, 3230, 3317], '(136)': [1634, 3233, 3320], '36Naim': [1637], 'Amarneh': [1639, 2068, 3533, 3702], 'Ktistakis': [1641, 2070, 3535, 3704], 'N.T.': [1642, 2071, 3536, 3705], 'Virol.': [1646, 2075, 3540, 3709], '7585-7588Crossref': [1649, 2078, 3543, 3712], '37Lottaz': [1653], 'Oberholzer': [1655], 'T.': [1656, 1974, 2033, 3443, 3612], 'Bähler': [1657], 'Semenza': [1659, 2042, 3452, 3621], 'FEBS': [1663], 'Lett.': [1664], '313:': [1666], '270-276Crossref': [1667], '(33)': [1670], '(38Jacob': [1691, 2273, 2533, 3329, 3770, 3984], 'R.': [1692, 2274, 2534, 3237, 3330, 3350, 3771, 3985], '2712-2721Abstract': [1704, 2286, 2546, 3249, 3342, 3783, 3997], 'position': [1714], 'relative': [1716], 'strength': [1717, 4329, 4399], 'tailless': [1728, 3297], 'mutant': [1730, 1993, 3150, 3467, 3636], '(LPH−ct)': [1731], '(39Naim': [1732, 2003, 2866, 3181, 3475, 3644], 'Eur.': [1736, 2007, 2870, 3185, 3361, 3479, 3648], '1996;': [1740, 2011, 2874, 3189, 3364, 3483, 3652], '70:': [1741, 2012, 2875, 3190, 3484, 3653], '198-208PubMed': [1742, 2013, 2876, 3191, 3485, 3654], 'chimeric': [1746, 1944], 'made': [1748], 'fusing': [1750], 'short,': [1758, 2056], '12-amino': [1759, 2057], 'acid-long': [1760], 'studied': [1768], 'MDCK': [1770, 2192, 2271, 2295, 2512, 2517, 2553, 3200, 3218, 3325, 3857, 4351], 'Wild': [1772], 'lacks': [1775], 'transported': [1781], '(40Roth': [1786], 'Gething': [1788, 2254, 2664], 'Sambrook': [1790, 1966, 2252, 2662], 'Giusti': [1792], 'Davis': [1794], 'Nayak': [1796], '1983;': [1801], '33:': [1802], '435-443Abstract': [1803], '(72)': [1809], 'but': [1812, 4291], 'point': [1813, 4061], 'mutations': [1814, 3550, 3719], 'identified': [1822], 'created': [1824], 'both': [1825], '41Lazarovits': [1872], '53:': [1878], '743-752Abstract': [1879], '(171)': [1885], '42Naim': [1888], '3928-3933Abstract': [1897, 2504, 2704], '43Naim': [1904], 'Dodds': [1906], 'D.T.': [1907], '129:': [1916], '1241-1250Crossref': [1917], '(39)': [1920], 'contrast': [1924, 4168], 'function': [1927], 'HA,': [1929, 3891], 'did': [1934, 3173], 'affect': [1936, 3175], 'strict': [1937], 'delivery': [1939], 'However,': [1942], 'gained': [1947], 'capacity': [1950], 'similar': [1951, 2138, 2880, 3208, 3860], 'those': [1953], 'counterparts.': [1957], 'Standard': [1958], 'recombinant': [1959, 2239, 2604], 'DNA': [1960, 2240, 2387], 'techniques': [1961], 'employed': [1963], 'according': [1964, 2181, 2725], 'et': [1967, 2656], 'al.': [1968, 2657], '(44Sambrook': [1969], 'Fritsch': [1971], 'E.F.': [1972], 'Maniatis': [1973], 'Molecular': [1975], 'Cloning:': [1976], 'A': [1977, 2137, 2879, 3880], 'Laboratory': [1978], 'Manual.': [1979], '2nd': [1980], 'Ed.': [1981], 'Cold': [1982, 1986], 'Spring': [1983, 1987], 'Harbor': [1984], 'Press,': [1985], 'Harbor,': [1988], 'NY1989Google': [1989], 'lacking': [1994, 3152, 3471, 3640], 'tail,': [1997], 'LPH−ct,': [1998], 'reported': [2001], 'previously': [2002, 2532, 3301, 3765], 'cDNAs': [2016], 'encoding': [2017, 2111, 2955, 3156], '(amino': [2025, 2063], '1–1901)': [2027], '(45Mantei': [2028, 3438, 3607], 'N.': [2029, 2362, 3439, 3608], 'Villa': [2030, 3440, 3609], 'Enzler': [2032, 3442, 3611], 'Wacker': [2034, 3444, 3613], 'Bol': [2036, 3446, 3615], 'James': [2038, 3448, 3617], '7:': [2047, 3457, 3626], '2705-2713Crossref': [2048, 3458, 3627], '(223)': [2051, 3461, 3630], 'acid-long,': [2058], '536–547)': [2065], '(36Naim': [2066, 3531, 3700], '(denoted': [2082, 3162, 4054], 'LPH-HA)': [2084], 'generated': [2086], 'polymerase': [2088, 2107], 'chain': [2089, 2108], 'reaction': [2090, 2109], 'SOEing': [2091], '(46Horton': [2092], 'R.M.': [2093], 'Cai': [2094], 'Z.L.': [2095], 'Ho': [2096], 'S.N.': [2097], 'Pease': [2098], 'L.R.': [2099], 'BioTechniques.': [2100], '8:': [2102, 3928], '528-535PubMed': [2103], 'product': [2110, 4314], 'LPH-HAwt': [2112, 2587], 'cloned': [2114], 'expression': [2117], 'vector': [2118], 'pJB20': [2119, 2954], '(32Brewer': [2120], 'strategy': [2139], 'utilized': [2141], 'construct': [2143], 'single': [2150], 'mutation': [2151, 2156], '(LPH-HAY543)': [2152], 'double': [2155, 3549, 3718], '(LPH-HAY543/Y546': [2157], 'LPH-HAY543/R546)': [2159], 'domain.': [2164], 'sequence': [2166, 3155, 3390, 3417, 3517, 3586, 3686], 'LPH−ct': [2168, 2324, 2556, 2956, 3197, 3281], 'chimera': [2172], 'sequencing': [2176], 'Sequenase': [2179], 'kit': [2180], 'instructions': [2184], 'manufacturer': [2187], '(U.': [2188], 'Biochemical': [2190], 'Corp.).': [2191], 'COS-1': [2195, 2244, 2949, 3169], 'maintained': [2198], '(DMEM,': [2204], 'Life': [2205], 'Technologies,': [2206, 2308], 'Inc.,': [2207], 'Eggenstein/Germany)': [2208], 'supplemented': [2209], '10%': [2211, 3007], 'fetal': [2212, 3008], 'bovine': [2213, 2994, 3087], 'serum,': [2214], '2': [2215, 2391, 2617, 2786, 2985], 'mm': [2216, 2794, 2799], 'glutamine,': [2217], '50': [2218, 2798], 'units/ml': [2219], 'penicillin,': [2220], 'streptomycin': [2222], 'at': [2223, 2390, 3015, 3061, 3093, 3806, 3822, 3838, 3963, 4056], '37': [2224, 3030], '°C': [2225, 3017, 3031], '5%': [2228, 2945, 2993, 3086], 'CO2atmosphere.': [2229], 'Cells': [2230, 4004], 'transfected': [2232, 2294, 2586, 2952, 3103, 3324], '5': [2234], 'μg': [2235], 'appropriate': [2238], 'using': [2241, 2350, 2895], 'DEAE-dextran': [2242], '(for': [2243, 2270], 'cells)': [2245, 2272], 'described': [2247, 2490, 2531, 2653, 3764], '(47Naim': [2248, 2658], 'Lacey': [2250, 2660], 'S.W.': [2251, 2661], 'J.F.': [2253, 2663], 'M.J.H.': [2255, 2665], '12313-12320Abstract': [2261, 2671], 'Polybrene': [2269], 'Stably': [2293], 'selected': [2298], 'presence': [2301], '0.25': [2303], 'mg/ml': [2304], 'active': [2305], 'G418': [2306], '(Life': [2307], 'Inc.),': [2309], '18–23': [2312], 'days,': [2313], 'surviving': [2314], 'colonies': [2315], 'isolated': [2317, 3815], 'cloning': [2319], 'rings.': [2320], 'Stable': [2321], 'transformants': [2322], 'expressing': [2323, 2555, 2584, 2762, 3204], 'screened': [2329], 'immunoprecipitation': [2331, 2432, 2467, 3748], 'immunofluorescence': [2334], 'staining.': [2335], 'Expression': [2336], 'Caco-2': [2342, 2474, 2482, 2582, 2606, 2899, 4240], 'preformed': [2345], 'transiently': [2346, 2585, 2951], 'filters': [2349, 2521, 2688, 3762], 'calcium': [2352], 'phosphate': [2353], 'procedure': [2354, 2882], '(48Low': [2355], 'S.H.': [2356, 2358], 'Wong': [2357], 'Tang': [2359], 'B.L.': [2360], 'Subramaniam': [2361], 'Hong': [2363], '13391-13396Abstract': [2370], 'Here,': [2377], 'grown': [2381, 2519, 2962, 3757], 'confluency': [2383], 'corresponding': [2386, 3830], 'added': [2389], 'μg/ml.': [2392], 'higher': [2394], 'transfection': [2395, 2405], 'efficiency': [2396, 4331], 'filters,': [2398], 'treated': [2402], 'prior': [2403], 'trypsin': [2407], 'dissociate': [2409], 'achieve': [2414, 2457], 'optimal': [2416], 'exposure': [2417], 'DNA.': [2421], 'Three': [2422], 'days': [2423], 'post-transfection': [2424], 'processed': [2428], 'mAb': [2434, 2625, 2812, 2988], 'anti-LPH': [2435, 2626, 2692, 2989], '(see': [2436], 'below)': [2437], 'labeling': [2440, 2515, 2600], '18': [2442, 2594], 'h.': [2443, 2618, 4112], 'We': [2444, 3966], 'found': [2445, 3166, 4084, 4142, 4223, 4253], '3-day': [2448], 'period': [2449], 'layer': [2455], 'complete': [2458], 'polarity.': [2459], 'This': [2460, 3516, 3685, 4259], 'biochemically': [2462], 'assessed': [2463, 3101], 'sucrase-isomaltase,': [2469], 'Infection': [2480], 'cDNA': [2486, 3151], 'performed': [2488, 2529, 2910], '(42Naim': [2495, 2695], 'Metabolic': [2514], 'plated': [2523], 'six-well': [2525], 'culture': [2526], 'dishes': [2527], 'clones': [2554], 'labeled': [2561, 2591, 2615, 2766, 4149, 4238], '1': [2563, 2768, 4010], 'h': [2564, 2595, 2769, 2787, 2968, 2986, 3803, 4011, 4063, 4066, 4091, 4233], '100': [2566], 'μCi': [2567], '[35S]methionine': [2569, 2771, 4008], '(10': [2570], 'mCi/mll-[35S]RedivueTMPro-mixTM,': [2571], 'Amersham,': [2572], 'Braunschweig/Germany)': [2573], 'chased': [2575, 2773, 3265, 4013], 'different': [2577], 'times': [2578], 'unlabeled': [2580], 'methionine.': [2581], 'LPH-HAY543/F546': [2589], 'continuously': [2592, 2614, 3203], 'ensure': [2597], 'maximum': [2599, 3523, 3692], 'proteins.': [2605], 'infected': [2608], 'HAwt': [2610], 'HAY543/F546': [2612], 'lysates': [2620], 'immunoprecipitated': [2622, 2683, 2810, 2845], 'mouse': [2624], '(from': [2627], 'hybridoma': [2628], 'HBB': [2629], '1/900/34/74)': [2630], '(34Hauri': [2631, 2917, 4182], 'antigens': [2681], 'intact': [2685], 'anti-HA': [2694], 'either': [2713], 'compartments.': [2718], 'immunoprecipitates': [2720, 2939], 'analyzed': [2722, 2941], 'SDS-PAGE': [2724, 2943], 'method': [2728], 'Laemmli': [2730], '(49Laemmli': [2731], 'U.K.': [2732], '1970;': [2734], '227:': [2735], '680-685Crossref': [2736], '(212382)': [2739], 'After': [2742, 3064], 'gels': [2745], 'fixed,': [2747], 'soaked': [2748], '16%': [2750], 'salicylic': [2751], 'acid': [2752], 'amplification,': [2755], 'subjected': [2757], 'fluorography.': [2759], 'MDCK-ML': [2760, 3980], 'biosynthetically': [2765, 4148, 4237], 'time': [2776, 4016, 4043, 4060], 'points.': [2777, 4017, 4044], 'solubilized': [2781], 'cold': [2784], '1%': [2789, 2821, 2832], 'Triton': [2790, 2833, 3110, 3961, 4023, 4226], 'X-100': [2791, 2834, 3111, 3962, 4227], '25': [2793], 'Tris-HCl,': [2795], 'pH': [2796], '8.0,': [2797], 'NaCl.': [2800], 'detergent': [2802, 2888, 4027, 4119], 'extracts': [2803, 2838], 'centrifuged,': [2805], 'supernatant': [2808, 2843, 4052, 4088, 4257], 'anti-LPH.': [2813], 'pellet': [2815, 4070, 4229], 'dissolved': [2817], 'boiling': [2819], 'SDS': [2822], '10': [2824, 3035], 'min.': [2825], 'Thereafter': [2826], '10-fold': [2827], 'volume': [2828], 'buffer': [2830], 'added.': [2836], 'centrifuged': [2840], 'mixture': [2848, 2913], 'antibodies,': [2852], 'MLac': [2853, 2856], '6': [2854], '10,': [2857], 'denatured': [2860, 2905], 'native': [2862, 2903], 'forms': [2863, 2906, 4032], 'experimental': [2881], 'followed': [2884], 'assess': [2886], 'solubility': [2889, 4028], 'sucrase-isomaltase': [2893, 2908, 4181, 4268], 'Immunoprecipitation': [2901], 'antibodies': [2916], '6%': [2947], 'gels.': [2948], 'duplicate': [2964], 'coverslips.': [2966], '48': [2967], 'post-transfection,': [2969], 'rinsed': [2972, 3048], 'ice-cold': [2974, 3050], 'DMEM': [2975, 3005, 3033], 'placed': [2977], 'ice.': [2979], 'incubated': [2983, 3072], 'diluted': [2990, 3083], '1:200': [2991], 'serum': [2995, 3088], 'albumin/PBS.': [2996], 'Unbound': [2997], 'removed': [3000], 'washes': [3003, 3066], 'calf': [3009], 'serum.': [3010], 'Control': [3011], 'samples': [3012, 3024], 'retained': [3014], '4': [3016, 3802, 3964, 4090, 4111], 'second': [3021], 'set': [3022], 'temperature': [3026], 'raised': [3028], 'min': [3036, 3060, 3092], 'circulating': [3039], 'water': [3040], 'bath.': [3041], 'chilled': [3045], 'ice,': [3047], 'PBS,': [3051, 3068], 'then': [3053], 'fixed': [3054], '2%': [3056], 'paraformaldehyde': [3057], '20': [3059], 'room': [3062, 3094], 'temperature.': [3063, 3095], 'fluorescein': [3074], 'isothiocyanate-conjugated': [3075], 'goat': [3076], 'anti-mouse': [3077], '(Boehringer': [3079], 'Mannheim,': [3080, 3081], 'Germany),': [3082], '1:100': [3084], 'albumin/PBS': [3089], '30': [3091], 'Intracellular': [3096], 'localization': [3097], 'permeabilized': [3107], '0.1%': [3109], 'fixing.': [3113], 'examined': [3117, 3968], 'Axioplan': [3120], 'fluorescence': [3121], 'microscope': [3122], '(Zeiss,': [3123], 'Oberkochen,': [3124], 'Germany)': [3125], 'equipped': [3126], '100×': [3129], 'immersion': [3130], 'objective.': [3131], 'evaluate': [3133], 'role': [3135, 4277], 'tail': [3139, 3159, 3554, 3723], 'its': [3143, 3752, 3862, 4312], 'sorting,': [3146], 'constructed': [3148, 4359], 'entire': [3154], 'pro-LPH−ct,': [3163], 'TableI)': [3164], 'transport-competence': [3177], 'molecule': [3180], 'Biosynthetic': [3194], 'processing': [3195, 3851], 'line': [3202, 3979], 'wild': [3212, 3383, 3435, 3604, 3767, 3863], 'pro-LPH': [3214, 3865, 3873, 3970, 3983, 4030, 4048, 4081, 4116, 4125, 4139, 4430], '(35Naim': [3220, 3307], '38Jacob': [3236], 'first': [3257, 3415, 3584], 'detectable': [3258], 'form,': [3260], '215-kDa': [3262, 4046, 4098], 'pro-LPH−ctspecies,': [3264], '230-kDa': [3270, 3796, 4080], 'pro-LPH–ct': [3271], 'polypeptide': [3272], '4–6': [3274], 'h,': [3275], 'cleaved': [3278, 3292, 4313], '(approximate': [3282], 'mass': [3285], 'kDa)': [3287], 'appeared': [3288, 4049], '(Fig.': [3289, 4242], '1).': [3290], '160-kDa': [3293], 'analogue': [3298], 'LPHβ': [3300], 'characterized': [3302], 'biopsy': [3305], 'specimens': [3306], 'CHO': [3327], '50Jacob': [3349], 'Radebach': [3351], 'Wüthrich': [3353], 'Grünberg': [3355], '236:': [3365], '789-795Crossref': [3366], '(26)': [3369], 'will': [3373], 'therefore': [3375, 3967], 'denoted': [3376], 'LPHβ−ct.Table': [3377], 'ITransmembrane': [3378], 'carboxyl-terminal': [3380], 'LPH-ct,': [3386], 'chimerasProteinTransmembrane': [3389], 'Cytoplasmic': [3391], 'sequenceLPHwtalyvlfslvllgvcglaflsykyckrskqgktqrsqqelspvssfLPH-ctalyvlfslvllgvcglaflLPH-HAwtalyvlfslvllgvcglaflcsngslqcriciLPH-HAY543alyvlfslvllgvcglaflcsngslqY': [3392], 'riciLPH-HAY543/F546alyvlfslvllgvcglaflcsngslqY': [3393], 'ri': [3394, 3397], 'F': [3395], 'iLPH-HAY543/R546alyvlfslvllgvcglaflcsngslqY': [3396], 'R': [3398], 'iAll': [3399], 'single-letter': [3404, 3573], 'code.': [3405, 3574], 'illustrated': [3410, 3579], 'bold': [3412, 3581], 'letters.': [3413, 3561, 3582, 3730], 'depicted': [3416, 3585], '(19': [3424, 3593], 'acids)': [3426, 3433, 3595, 3602], '(26': [3431, 3600], 'LPH-ct': [3464, 3633], 'Chimeras': [3488, 3657], 'indicated': [3504, 3558, 3673, 3727, 4434], 'LPH-HA.': [3506, 3675], 'contains': [3512, 3681, 4323], '12': [3513, 3682], 'predicted': [3519, 3688], 'length': [3524, 3693], 'A/Japan': [3527, 3696], 'Single': [3547, 3716], 'underlined': [3560, 3729], 'Open': [3562], 'table': [3563], 'new': [3566], 'tab': [3567], 'kinetics': [3732], 'appearance': [3734], 'pro-LPH−ct': [3736, 3750, 3797, 3855], 'derivative': [3753], 'LPHβ−ct': [3754], 'transparent': [3759], 'polyester': [3760], 'Fig.2': [3790], 'shows': [3791, 4039], 'LPHβ−ctappeared': [3800], 'chase': [3805, 3825, 4042, 4059, 4093, 4105, 4235], 'surface.': [3809, 3841], 'intensity': [3811], 'bands': [3814, 3829], 'became': [3820], 'stronger': [3821], '6-h': [3824], 'point.': [3826], 'No': [3827], 'significant': [3828], 'species': [3835], 'detected': [3837], 'Together,': [3842], 'pulse-chase': [3844], 'analyses': [3847], 'indicate': [3848], 'counterpart': [3866], 'cytosolic': [3870, 4412, 4437], 'portion': [3871], 'devoid': [3875, 4073], 'apically': [3883, 4309, 4316], 'sorted': [3884, 4365], 'neuraminidase,': [3890], 'selectively': [3901], 'associated': [3902, 3972, 4128, 4270], 'sphingolipid-cholesterol': [3904, 4130, 4272], 'rafts': [3905, 3974, 4273], '51Rodriguez-Boulan': [3919], 'Annu.': [3923], 'Rev.': [3924], '395-427Crossref': [3929], '(357)': [3932], '52Danielsen': [3935], 'Biochemistry.': [3937, 4158], '34:': [3939, 4160], '1596-1605Crossref': [3940, 4161], '(129)': [3943, 4164], 'One': [3946], 'characteristics': [3949], 'protein-membrane': [3952], 'structures': [3953, 4280], 'insolubility': [3956, 4034], 'detergents': [3958], '°C.': [3965], 'whether': [3969], 'expresses': [3982], 'pulse-labeled': [4006], 'extracted': [4021], 'X-100,': [4024], 'versus': [4033], 'examined.': [4036], 'Fig.': [4037], '3': [4038, 4232], 'representative': [4041], 'fraction': [4053, 4121], 'S)': [4055], 'earliest': [4058], '(1': [4062], 'pulse,': [4064], '0': [4065], 'chase),': [4067], '(P)': [4071, 4122, 4230], 'form.': [4076], 'also': [4083], 'exclusively': [4085], 'together': [4094], 'species.': [4099], 'Similar': [4100], 'obtained': [4103], 'points': [4106], 'later': [4109], 'absence': [4114], 'insoluble': [4120, 4228], 'indicates': [4123, 4261], 'rafts.': [4131], 'data': [4133], 'agree': [4134], 'previous': [4136], 'only': [4141, 4254], 'detergent-soluble': [4145], 'explants': [4150], 'pig': [4153], 'intestine': [4155], '(52Danielsen': [4156], 'By': [4167], 'pro-LPH,': [4170], '245-kDa': [4172, 4264], 'mature': [4175, 4265], 'another': [4178], 'protein,': [4180], '53Naim': [4203], '263:': [4213], '7242-7253Abstract': [4214], '3).': [4243], '(210-kDa),': [4247], 'hand,': [4251], '(Fig.3).': [4258], 'result': [4260], 'suggests': [4275], 'glycoprotein': [4286], 'membrane,': [4290], 'high': [4299], 'fidelity': [4300], '(more': [4305], '90%': [4307], 'targeted)': [4310], '(exclusively': [4315], 'located)': [4317], 'strongly': [4318], 'lead': [4338], 'notion': [4341], 'Consistent': [4353], 'concept,': [4356], 'examine': [4397], 'potential': [4402], 'molecule,': [4409], 'same': [4411], 'completely': [4415], 'reversed': [4416], 'polarity': [4418], 'fused': [4422], 'ectodomain': [4425], '(the': [4431], 'LPH-HA).': [4435], 'm': [4442]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1964235448', 'counts_by_year': [{'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-15T18:55:57.775284', 'created_date': '2016-06-24'}
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