Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W1964191104', 'doi': 'https://doi.org/10.1073/pnas.86.19.7321', 'title': 'Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins.', 'display_name': 'Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins.', 'publication_year': 1989, 'publication_date': '1989-10-01', 'ids': {'openalex': 'https://openalex.org/W1964191104', 'doi': 'https://doi.org/10.1073/pnas.86.19.7321', 'mag': '1964191104', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/2552439', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/298053'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.86.19.7321', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1073/pnas.86.19.7321', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5066835130', 'display_name': 'Tommaso Costa', 'orcid': 'https://orcid.org/0000-0002-8729-3357'}, 'institutions': [{'id': 'https://openalex.org/I4210145969', 'display_name': 'Max Planck Institute of Psychiatry', 'ror': 'https://ror.org/04dq56617', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210145969']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'T Costa', 'raw_affiliation_strings': ['Department of Neuropharmacology, Max-Planck-Institut fur Psychiatrie, Martinsried, Federal Republic of Germany.'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuropharmacology, Max-Planck-Institut fur Psychiatrie, Martinsried, Federal Republic of Germany.', 'institution_ids': ['https://openalex.org/I4210145969']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5111312287', 'display_name': 'A. Herz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210145969', 'display_name': 'Max Planck Institute of Psychiatry', 'ror': 'https://ror.org/04dq56617', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I149899117', 'https://openalex.org/I4210145969']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'A Herz', 'raw_affiliation_strings': ['Department of Neuropharmacology, Max-Planck-Institut fur Psychiatrie, Martinsried, Federal Republic of Germany.'], 'affiliations': [{'raw_affiliation_string': 'Department of Neuropharmacology, Max-Planck-Institut fur Psychiatrie, Martinsried, Federal Republic of Germany.', 'institution_ids': ['https://openalex.org/I4210145969']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.092, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 525, 'citation_normalized_percentile': {'value': 0.999958, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '86', 'issue': '19', 'first_page': '7321', 'last_page': '7325'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11178', 'display_name': 'Receptor Mechanisms and Signaling', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10814', 'display_name': 'Neuropeptides and Animal Physiology', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10077', 'display_name': 'Neuroscience and Neuropharmacology Research', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/gtp-binding-protein-regulators', 'display_name': 'GTP-binding protein regulators', 'score': 0.53085667}, {'id': 'https://openalex.org/keywords/rhodopsin-like-receptors', 'display_name': 'Rhodopsin-like receptors', 'score': 0.52853054}, {'id': 'https://openalex.org/keywords/δ-opioid-receptor', 'display_name': 'δ-opioid receptor', 'score': 0.43777233}], 'concepts': [{'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.75561374}, {'id': 'https://openalex.org/C80631254', 'wikidata': 'https://www.wikidata.org/wiki/Q407438', 'display_name': 'G protein', 'level': 3, 'score': 0.68462014}, {'id': 'https://openalex.org/C38533456', 'wikidata': 'https://www.wikidata.org/wiki/Q1671589', 'display_name': 'Intrinsic activity', 'level': 4, 'score': 0.6164351}, {'id': 'https://openalex.org/C207332259', 'wikidata': 'https://www.wikidata.org/wiki/Q769143', 'display_name': 'GTPase', 'level': 2, 'score': 0.5801098}, {'id': 'https://openalex.org/C135285700', 'wikidata': 'https://www.wikidata.org/wiki/Q38173', 'display_name': 'G protein-coupled receptor', 'level': 3, 'score': 0.5599239}, {'id': 'https://openalex.org/C85771745', 'wikidata': 'https://www.wikidata.org/wiki/Q5514732', 'display_name': 'GTP-binding protein regulators', 'level': 4, 'score': 0.53085667}, {'id': 'https://openalex.org/C42221972', 'wikidata': 'https://www.wikidata.org/wiki/Q7321217', 'display_name': 'Rhodopsin-like receptors', 'level': 5, 'score': 0.52853054}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5007038}, {'id': 'https://openalex.org/C163181125', 'wikidata': 'https://www.wikidata.org/wiki/Q408592', 'display_name': 'GTPase-activating protein', 'level': 4, 'score': 0.47769597}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.45998874}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.45486635}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.43794557}, {'id': 'https://openalex.org/C141087196', 'wikidata': 'https://www.wikidata.org/wiki/Q18030283', 'display_name': 'δ-opioid receptor', 'level': 4, 'score': 0.43777233}, {'id': 'https://openalex.org/C118716', 'wikidata': 'https://www.wikidata.org/wiki/Q5514725', 'display_name': "GTP'", 'level': 3, 'score': 0.427207}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.41934815}, {'id': 'https://openalex.org/C33235085', 'wikidata': 'https://www.wikidata.org/wiki/Q4355943', 'display_name': 'G protein-coupled receptor kinase', 'level': 4, 'score': 0.41549605}, {'id': 'https://openalex.org/C26702167', 'wikidata': 'https://www.wikidata.org/wiki/Q901988', 'display_name': 'Metabotropic receptor', 'level': 4, 'score': 0.17442495}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D019204', 'descriptor_name': 'GTP-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009292', 'descriptor_name': 'Narcotic Antagonists', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011957', 'descriptor_name': 'Receptors, Opioid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001575', 'descriptor_name': 'Benzomorphans', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D001575', 'descriptor_name': 'Benzomorphans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002462', 'descriptor_name': 'Cell Membrane', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002462', 'descriptor_name': 'Cell Membrane', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004743', 'descriptor_name': 'Enkephalin, Leucine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004743', 'descriptor_name': 'Enkephalin, Leucine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004743', 'descriptor_name': 'Enkephalin, Leucine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D016308', 'descriptor_name': 'Enkephalin, Leucine-2-Alanine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005033', 'descriptor_name': 'Ethylmaleimide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005033', 'descriptor_name': 'Ethylmaleimide', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D020558', 'descriptor_name': 'GTP Phosphohydrolases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020558', 'descriptor_name': 'GTP Phosphohydrolases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019204', 'descriptor_name': 'GTP-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005910', 'descriptor_name': 'Glioma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009292', 'descriptor_name': 'Narcotic Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009447', 'descriptor_name': 'Neuroblastoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D037342', 'descriptor_name': 'Pertussis Toxin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011957', 'descriptor_name': 'Receptors, Opioid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017465', 'descriptor_name': 'Receptors, Opioid, delta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010566', 'descriptor_name': 'Virulence Factors, Bordetella', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010566', 'descriptor_name': 'Virulence Factors, Bordetella', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.86.19.7321', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc298053', 'pdf_url': 'https://europepmc.org/articles/pmc298053?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC298053', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/2552439', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.86.19.7321', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.44, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 39, 'referenced_works': ['https://openalex.org/W1484188159', 'https://openalex.org/W1490796893', 'https://openalex.org/W1521164056', 'https://openalex.org/W1563758157', 'https://openalex.org/W1585180155', 'https://openalex.org/W1586780384', 'https://openalex.org/W1600624424', 'https://openalex.org/W1603388985', 'https://openalex.org/W1640849052', 'https://openalex.org/W1878008853', 'https://openalex.org/W1980104563', 'https://openalex.org/W2000485393', 'https://openalex.org/W2014365512', 'https://openalex.org/W2017659544', 'https://openalex.org/W2032238533', 'https://openalex.org/W2043813981', 'https://openalex.org/W2046753575', 'https://openalex.org/W2047865327', 'https://openalex.org/W2052673887', 'https://openalex.org/W2053179621', 'https://openalex.org/W2057971042', 'https://openalex.org/W2064792414', 'https://openalex.org/W2067666775', 'https://openalex.org/W2075676530', 'https://openalex.org/W2075811628', 'https://openalex.org/W2076118656', 'https://openalex.org/W2080003856', 'https://openalex.org/W2080413833', 'https://openalex.org/W2080875376', 'https://openalex.org/W2104349140', 'https://openalex.org/W2125788939', 'https://openalex.org/W2132376958', 'https://openalex.org/W2139129258', 'https://openalex.org/W2303533163', 'https://openalex.org/W2341030545', 'https://openalex.org/W2403094095', 'https://openalex.org/W2406823737', 'https://openalex.org/W2414233442', 'https://openalex.org/W2460328999'], 'related_works': ['https://openalex.org/W47331740', 'https://openalex.org/W2933693412', 'https://openalex.org/W2742016924', 'https://openalex.org/W2111535188', 'https://openalex.org/W2035774084', 'https://openalex.org/W2022778785', 'https://openalex.org/W2014385979', 'https://openalex.org/W1988509223', 'https://openalex.org/W1964191104', 'https://openalex.org/W1517658624'], 'abstract_inverted_index': {'According': [0], 'to': [1, 14, 16, 38, 52, 75], 'classical': [2], 'models': [3], 'of': [4, 64, 72, 94, 97, 104, 110, 131, 148, 179, 190, 193, 203], 'drug-receptor': [5], 'interactions,': [6], 'competitive': [7, 111, 208], 'antagonists': [8, 112, 180], 'share': [9], 'with': [10, 181], 'agonists': [11], 'the': [12, 21, 34, 84, 128, 139], 'ability': [13, 71], 'bind': [15], 'a': [17, 61, 66, 92, 187, 201], 'common': [18], 'site': [19], 'on': [20, 83], 'receptor': [22, 74, 140, 149], 'molecule.': [23, 86], 'However,': [24], 'they': [25, 31, 41], 'are': [26, 50], 'different': [27], 'from': [28, 174], 'agonists,': [29], 'as': [30], 'cannot': [32], 'trigger': [33], '"stimulus"': [35], 'that': [36, 90], 'leads': [37], 'biological': [39, 204], 'responses--i.e.,': [40], 'lack': [42], 'intrinsic': [43, 120, 164, 183], 'activity.': [44], 'For': [45], 'those': [46], 'receptors': [47, 98, 101, 169, 197], 'whose': [48], 'signals': [49], 'transduced': [51], 'effector': [53], 'systems': [54], 'by': [55, 144, 207], 'GTP-binding': [56], 'regulatory': [57], 'proteins': [58, 133], '(G': [59], 'proteins),': [60], 'mechanistic': [62], 'equivalent': [63], 'such': [65], 'stimulus': [67], 'is': [68, 141, 170], 'an': [69], 'increased': [70, 171], 'agonist-bound': [73], 'accelerate': [76], 'nucleotide': [77], 'exchange': [78], 'and': [79, 134, 150, 160, 198], 'thus': [80, 161], 'GTPase': [81, 129, 159], 'activity': [82, 130, 184], 'G-protein': [85], 'Here': [87], 'we': [88], 'show': [89], 'for': [91, 138, 168, 200], 'member': [93], 'this': [95], 'family': [96], '(delta': [99], 'opioid': [100], 'in': [102], 'membranes': [103], 'NG108-15': [105], 'neuroblastoma-glioma': [106], 'cells),': [107], 'two': [108], 'types': [109], 'can': [113, 157], 'be': [114, 186], 'distinguished.': [115], 'One': [116], 'type': [117], 'has': [118], 'no': [119], 'activity,': [121], 'since': [122], 'it': [123], 'neither': [124], 'stimulates': [125], 'nor': [126], 'inhibits': [127], 'G': [132, 151, 175], 'its': [135, 166], 'apparent': [136], 'affinity': [137, 167], 'not': [142], 'altered': [143], 'pertussis': [145], 'toxin-mediated': [146], 'uncoupling': [147, 173], 'protein.': [152], 'The': [153, 177], 'second': [154], 'type,': [155], 'however,': [156], 'inhibit': [158], 'exhibits': [162], 'negative': [163, 182], 'activity;': [165], 'following': [172], 'proteins.': [176], 'existence': [178], 'may': [185], 'general': [188], 'feature': [189], 'several': [191], 'classes': [192], 'neurotransmitters': [194], 'or': [195], 'hormone': [196], 'calls': [199], 'reevaluation': [202], 'effects': [205], 'produced': [206], 'antagonists.': [209]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W1964191104', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 10}, {'year': 2021, 'cited_by_count': 15}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 12}, {'year': 2015, 'cited_by_count': 18}, {'year': 2014, 'cited_by_count': 17}, {'year': 2013, 'cited_by_count': 19}, {'year': 2012, 'cited_by_count': 15}], 'updated_date': '2025-01-12T06:00:02.499535', 'created_date': '2016-06-24'}