Title: Functionalized Nanoparticles with Long‐Term Stability in Biological Media
Abstract: SmallVolume 5, Issue 14 p. 1637-1641 Communication Functionalized Nanoparticles with Long-Term Stability in Biological Media† Chen Fang, Chen Fang Department of Materials Science and Engineering University of Washington Seattle, WA 98195 (USA)Search for more papers by this authorNarayan Bhattarai, Narayan Bhattarai Department of Materials Science and Engineering University of Washington Seattle, WA 98195 (USA)Search for more papers by this authorConroy Sun, Conroy Sun Department of Materials Science and Engineering University of Washington Seattle, WA 98195 (USA)Search for more papers by this authorMiqin Zhang, Corresponding Author Miqin Zhang [email protected] Department of Materials Science and Engineering University of Washington Seattle, WA 98195 (USA)Department of Materials Science and Engineering University of Washington Seattle, WA 98195 (USA).Search for more papers by this author Chen Fang, Chen Fang Department of Materials Science and Engineering University of Washington Seattle, WA 98195 (USA)Search for more papers by this authorNarayan Bhattarai, Narayan Bhattarai Department of Materials Science and Engineering University of Washington Seattle, WA 98195 (USA)Search for more papers by this authorConroy Sun, Conroy Sun Department of Materials Science and Engineering University of Washington Seattle, WA 98195 (USA)Search for more papers by this authorMiqin Zhang, Corresponding Author Miqin Zhang [email protected] Department of Materials Science and Engineering University of Washington Seattle, WA 98195 (USA)Department of Materials Science and Engineering University of Washington Seattle, WA 98195 (USA).Search for more papers by this author First published: 30 July 2009 https://doi.org/10.1002/smll.200801647Citations: 206 † The work was supported by a grant (R01CA119408) from the National Cancer Institute, the National Institute of Health. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract A surface-engineering approach to produce monodisperse nanoparticles functionalized for conjugations of various biomolecules is described. The oleic acid-capped nanoparticles are modified with triethoxysilylpropylsuccinic anhydride followed by reaction with aminated poly(ethylene glycol) (PEG) to render the nanoparticles hydrophilic and display amine groups at the free termini of PEG chains (see image). Supporting Information Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Filename Description smll_200801647_sm_supplfigs.pdf501.2 KB supplfigs Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. References 1 D. Peer, J. M. Karp, S. Hong, O. C. Farokhzad, R. Margalit, R. Langer, Nat. Nanotechnol. 2007, 2, 751. 10.1038/nnano.2007.387 CASPubMedWeb of Science®Google Scholar 2 C. Sun, J. S. H. Lee, M. Zhang, Adv. Drug Delivery Rev. 2008, 60, 1252. 10.1016/j.addr.2008.03.018 CASPubMedWeb of Science®Google Scholar 3 W. B. Cai, X. Y. Chen, Small 2007, 3, 1840. 10.1002/smll.200700351 CASPubMedWeb of Science®Google Scholar 4 R. Weissleder, M. J. 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